compound 27 [PMID: 20598884]


SMILES N#Cc1cc(F)cc(c1)C(=O)Nc1cccc(c1)Cl
InChIKey FNDUFJARTKDXEF-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 2
Molecular weight (Da) 274.0

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 6.69 6.69 6.69 Guide to Pharmacology
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 6.69 6.69 6.69 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 7.35 7.35 7.35 Guide to Pharmacology
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 7.35 7.35 7.35 ChEMBL