compound 2 [PMID: 21105727]
| SMILES | O/N=C\1/c2ccccc2OC2(C1C2)C(=O)Nc1ccc(cc1)Cl |
| InChIKey | ZRURMLHGCOJTNX-HKWRFOASSA-N |
Chemical properties
| Hydrogen bond acceptors | 4 |
| Hydrogen bond donors | 2 |
| Rotatable bonds | 2 |
| Molecular weight (Da) | 328.1 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | No |
Database connections
Sankey plot
Compound is not listed as a drug.
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| mGlu2 | GRM2 | Human | Metabotropic glutamate | C | pKi | 6.0 | 6.0 | 6.0 | Guide to Pharmacology |
| mGlu2 | GRM2 | Human | Metabotropic glutamate | C | pKi | 6.0 | 6.0 | 6.0 | ChEMBL |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| mGlu2 | GRM2 | Human | Metabotropic glutamate | C | pIC50 | 6.1 | 6.1 | 6.1 | Guide to Pharmacology |
| mGlu3 | GRM3 | Human | Metabotropic glutamate | C | pEC50 | 4.9 | 4.9 | 4.9 | Guide to Pharmacology |
| mGlu2 | GRM2 | Human | Metabotropic glutamate | C | pIC50 | 6.1 | 6.1 | 6.1 | ChEMBL |
| mGlu3 | GRM3 | Human | Metabotropic glutamate | C | pEC50 | 4.87 | 4.87 | 4.87 | ChEMBL |