GPCRdb

2-methyl-5-HT

Agent/drug
Bioactivity

2-methyl-5-HT

SMILES	Cc1[nH]c2ccc(O)cc2c1CCN
InChIKey	WYWNEDARFVJQSG-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	3
Rotatable bonds	2
Molecular weight (Da)	190.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	5-HT_2A

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.51	5.51	5.51	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.60	5.76	5.92	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.10	6.10	6.10	Guide to Pharmacology
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.04	6.13	6.29	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	6.28	6.28	6.28	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.70	5.95	6.20	Guide to Pharmacology
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.91	5.91	5.91	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.77	5.92	6.07	PDSP Ki database
5-HT_1D	F1MMU1	Bovine	5-Hydroxytryptamine	A	pKi	6.40	6.40	6.40	PDSP Ki database
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	6.10	6.10	6.10	Guide to Pharmacology
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	6.09	6.09	6.09	PDSP Ki database
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	6.40	6.40	6.40	Guide to Pharmacology
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	6.38	6.38	6.38	PDSP Ki database
5-HT_2B	5HT2B	Rat	5-Hydroxytryptamine	A	pKi	6.60	6.60	6.60	Guide to Pharmacology
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.71	6.71	6.71	PDSP Ki database
5-HT_2B	5HT2B	Rat	5-Hydroxytryptamine	A	pKi	6.50	6.53	6.55	PDSP Ki database
5-HT_2B	5HT2B	Mouse	5-Hydroxytryptamine	A	pKi	5.18	5.18	5.18	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.86	5.86	5.86	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	6.19	6.19	6.19	ChEMBL

Showing 1 to 20 of 30 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

NPS	NPSR1	Human	Neuropeptide S	A	Potency	4.90	4.90	4.90	ChEMBL

Showing 1 to 1 of 1 entry

2-methyl-5-HT

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV 0

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	5-HT_2A

Compound is not listed as a drug.