dicyclomine


SMILES CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC
InChIKey CURUTKGFNZGFSE-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 7
Molecular weight (Da) 309.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Sankey plot

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 9.08 9.08 9.08 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.6 6.6 6.6 Guide to Pharmacology
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 9.03 9.03 9.03 Guide to Pharmacology
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.3 8.3 8.3 Guide to Pharmacology
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 7.33 7.33 7.33 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 8.61 8.61 8.61 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.77 8.77 8.77 ChEMBL
H2 HRH2 Human Histamine A pKi 5.8 5.8 5.8 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 9.39 9.39 9.39 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 9.03 9.03 9.03 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.85 5.85 5.85 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.08 6.08 6.08 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 7.8 7.8 7.8 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.61 6.61 6.61 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 9.08 9.08 9.08 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.39 6.39 6.39 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.16 7.16 7.16 ChEMBL
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 8.75 8.75 8.75 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.61 6.61 6.61 PDSP Ki database
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 7.49 7.49 7.49 PDSP Ki database
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 9.21 9.21 9.21 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.82 8.82 8.82 PDSP Ki database
M4 ACM4 Chicken Acetylcholine (muscarinic) A pKi 8.26 8.26 8.26 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.15 8.15 8.15 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.22 8.22 8.22 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.18 8.18 8.18 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.23 8.23 8.23 Drug Central
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.04 8.04 8.04 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.18 8.18 8.18 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.04 8.04 8.04 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.03 8.03 8.03 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.06 8.06 8.06 Drug Central
D3 DRD3 Human Dopamine A pKi 8.19 8.19 8.19 Drug Central
H2 HRH2 Human Histamine A pKi 8.24 8.24 8.24 Drug Central
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 8.13 8.13 8.13 Drug Central
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 8.06 8.06 8.06 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 6.95 7.2 7.45 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pIC50 8.62 8.62 8.62 ChEMBL
H2 HRH2 Human Histamine A pIC50 5.79 5.79 5.79 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pIC50 8.53 8.53 8.53 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pIC50 8.36 8.36 8.36 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pIC50 5.51 5.51 5.51 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 5.89 5.89 5.89 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pIC50 7.34 7.34 7.34 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 6.33 6.33 6.33 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pIC50 8.46 8.46 8.46 ChEMBL
D3 DRD3 Human Dopamine A pIC50 5.92 5.92 5.92 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 6.62 6.62 6.62 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 4.6 4.6 4.6 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.6 4.6 4.6 ChEMBL