GPCRdb

MAPROTILINE

Agent/drug
Bioactivity

MAPROTILINE

SMILES	CNCCCC12CCC(c3ccccc31)c1ccccc12
InChIKey	QSLMDECMDJKHMQ-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	1
Hydrogen bond donors	1
Rotatable bonds	4
Molecular weight (Da)	277.2

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	6.64	6.64	6.64	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	7.05	7.05	7.05	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.15	8.15	8.15	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.71	6.71	6.71	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.17	8.17	8.17	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.17	6.17	6.17	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.88	6.88	6.88	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.16	8.16	8.16	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.36	6.36	6.36	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.20	8.20	8.20	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.75	7.75	7.75	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.16	8.16	8.16	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.67	6.67	6.67	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.18	8.18	8.18	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	7.39	7.39	7.39	ChEMBL
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	6.91	6.91	6.91	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.13	8.13	8.13	Drug Central
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	6.38	6.38	6.38	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	8.19	8.19	8.19	Drug Central

Showing 1 to 20 of 48 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	6.25	6.25	6.25	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pIC50	8.01	8.01	8.01	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.20	8.20	8.20	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	6.79	6.79	6.79	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	6.40	6.40	6.40	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.74	5.74	5.74	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	6.54	6.54	6.54	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	5.52	5.52	5.52	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	7.19	7.19	7.19	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.47	6.47	6.47	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	7.11	7.11	7.11	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	6.05	6.05	6.05	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	6.43	6.43	6.43	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	5.46	5.46	5.46	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	6.19	6.19	6.19	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	8.06	8.06	8.06	ChEMBL
H₂	HRH2	Human	Histamine	A	pIC50	6.40	6.40	6.40	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	5.35	5.50	5.65	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	6.23	6.23	6.23	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pIC50	5.71	5.71	5.71	ChEMBL

Showing 1 to 20 of 24 entries

MAPROTILINE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.