GPCRdb

BIFEPRUNOX

Agent/drug
Bioactivity

BIFEPRUNOX

SMILES	O=c1[nH]c2cccc(N3CCN(Cc4cccc(-c5ccccc5)c4)CC3)c2o1
InChIKey	CYGODHVAJQTCBG-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	4
Molecular weight (Da)	385.2

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	7.19	7.19	7.19	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.03	8.03	8.03	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pKi	8.81	8.81	8.81	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	8.64	9.17	10.40	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	10.00	10.20	10.40	PDSP Ki database

Showing 1 to 5 of 5 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pEC50	6.49	6.49	6.49	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	8.54	8.54	8.54	ChEMBL

Showing 1 to 2 of 2 entries

BIFEPRUNOX

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.