fasiglifam


SMILES OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C
InChIKey BZCALJIHZVNMGJ-HSZRJFAPSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 11
Molecular weight (Da) 524.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 4PHU 8EJC 8EJK

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
FFA1 FFAR1 Rat Free fatty acid A pKi 6.85 6.85 6.85 ChEMBL
FFA1 FFAR1 Human Free fatty acid A pKi 7.42 7.62 8.11 ChEMBL
FFA1 FFAR1 Human Free fatty acid A pKd 7.92 8.13 8.35 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
FFA1 FFAR1 Human Free fatty acid A pEC50 7.1 7.1 7.1 Guide to Pharmacology
FFA1 FFAR1 Mouse Free fatty acid A pEC50 8.07 8.07 8.07 ChEMBL
FFA1 FFAR1 Rat Free fatty acid A pEC50 4.57 6.61 7.44 ChEMBL
FFA1 FFAR1 Human Free fatty acid A pEC50 5.29 7.54 9.46 ChEMBL