fezolinetant


SMILES Fc1ccc(cc1)C(=O)N1CCn2c([C@H]1C)nnc2c1snc(n1)C
InChIKey PPSNFPASKFYPMN-SECBINFHSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 2
Molecular weight (Da) 358.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Sankey plot

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NK3 NK3R Human Tachykinin A pKi 7.6 7.6 7.6 Guide to Pharmacology
NK3 NK3R Rat Tachykinin A pKi 6.66 6.66 6.66 ChEMBL
NK3 NK3R Human Tachykinin A pKi 7.6 7.62 7.64 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NK3 NK3R Human Tachykinin A pIC50 7.7 7.72 7.75 ChEMBL