intepirdine


SMILES O=S(=O)(c1cnc2c(c1)cccc2N1CCNCC1)c1ccccc1
InChIKey JJZFWROHYSMCMU-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 3
Molecular weight (Da) 353.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 9.77 9.77 9.77 Guide to Pharmacology
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 9.63 9.63 9.63 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 4.85 4.85 4.85 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.85 9.38 9.78 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.62 6.27 7.58 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.0 6.0 6.0 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.58 7.58 7.58 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pIC50 7.01 8.16 8.55 ChEMBL