JNJ-16567083


SMILES CO[C@@H]1CC[C@@H](CC1)C(=O)c1ccc2c(c1)cc(c(n2)C)CC
InChIKey VEURHZYLLRSEGL-RHNCMZPLSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight (Da) 311.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 8.85 8.85 8.85 Guide to Pharmacology
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 9.06 9.06 9.06 ChEMBL
mGlu1 GRM1 Human Metabotropic glutamate C pKi 9.06 9.06 9.06 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 5.63 5.63 5.63 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Rat Metabotropic glutamate C pIC50 8.52 8.52 8.52 ChEMBL