levorphanol
SMILES | Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C |
InChIKey | JAQUASYNZVUNQP-USXIJHARSA-N |
Chemical properties
Hydrogen bond acceptors | 2 |
Hydrogen bond donors | 1 |
Rotatable bonds | 0 |
Molecular weight (Da) | 257.2 |
Drug properties
Molecular type | Small molecule |
Physiological/Surrogate | Surrogate |
Approved drug | Yes |
Database connections
Sankey plot
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
κ | OPRK | Mouse | Opioid | A | pKi | 8.0 | 8.0 | 8.0 | ChEMBL |
κ | OPRK | Guinea pig | Opioid | A | pKi | 8.64 | 8.64 | 8.64 | ChEMBL |
δ | OPRD | Human | Opioid | A | pKi | 8.38 | 8.38 | 8.38 | ChEMBL |
κ | OPRK | Human | Opioid | A | pKi | 8.64 | 8.64 | 8.64 | ChEMBL |
μ | OPRM | Human | Opioid | A | pKi | 9.68 | 9.68 | 9.68 | ChEMBL |
δ | OPRD | Human | Opioid | A | pKi | 8.08 | 8.08 | 8.08 | Drug Central |
κ | OPRK | Human | Opioid | A | pKi | 8.06 | 8.06 | 8.06 | Drug Central |
μ | OPRM | Human | Opioid | A | pKi | 8.01 | 8.01 | 8.01 | Drug Central |
κ | OPRK | Mouse | Opioid | A | pKi | 8.1 | 8.1 | 8.1 | Drug Central |
μ | OPRM | Mouse | Opioid | A | pKi | 8.02 | 8.02 | 8.02 | Drug Central |
κ | OPRK | Guinea pig | Opioid | A | pKi | 8.06 | 8.06 | 8.06 | Drug Central |
μ | OPRM | Mouse | Opioid | A | pKi | 9.52 | 9.52 | 9.52 | ChEMBL |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
μ | OPRM | Human | Opioid | A | pIC50 | 9.89 | 9.89 | 9.89 | Guide to Pharmacology |
δ | OPRD | Human | Opioid | A | pIC50 | 8.29 | 8.41 | 8.54 | ChEMBL |
κ | OPRK | Human | Opioid | A | pIC50 | 8.4 | 8.4 | 8.4 | ChEMBL |
μ | OPRM | Human | Opioid | A | pIC50 | 9.89 | 9.89 | 9.89 | ChEMBL |
μ | OPRM | Mouse | Opioid | A | pIC50 | 6.56 | 6.56 | 6.56 | ChEMBL |