L-glutamic acid


SMILES OC(=O)CC[C@@H](C(=O)O)N
InChIKey WHUUTDBJXJRKMK-VKHMYHEASA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 4
Molecular weight (Da) 147.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Endogenous
Approved drug Yes

Database connections

Structure pdb 7MTS 7MTR 8JD0 8JD3 8JD1 8JD5 8JD2 8JD4

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pKi 4.9 4.9 4.9 Guide to Pharmacology
mGlu3 GRM3 Human Metabotropic glutamate C pKi 7.4 7.4 7.4 Guide to Pharmacology
mGlu7 GRM7 Human Metabotropic glutamate C pKi 3.1 3.1 3.1 Guide to Pharmacology
mGlu3 GRM3 Rat Metabotropic glutamate C pKi 6.4 6.4 6.4 Guide to Pharmacology
mGlu2 GRM2 Rat Metabotropic glutamate C pKi 5.4 5.65 5.9 Guide to Pharmacology
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 6.4 6.45 6.5 Guide to Pharmacology
mGlu4 GRM4 Rat Metabotropic glutamate C pKi 4.9 5.2 5.5 Guide to Pharmacology
mGlu8 GRM8 Rat Metabotropic glutamate C pKi 5.47 5.47 5.47 ChEMBL
mGlu8 GRM8 Human Metabotropic glutamate C pKi 5.02 5.02 5.02 ChEMBL
mGlu6 GRM6 Human Metabotropic glutamate C pKi 4.42 4.42 4.42 ChEMBL
mGlu4 GRM4 Rat Metabotropic glutamate C pKi 5.47 5.47 5.47 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pKi 5.05 6.14 7.24 ChEMBL
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 6.47 6.47 6.47 ChEMBL
mGlu1 GRM1 Human Metabotropic glutamate C pKi 5.0 5.91 6.6 ChEMBL
mGlu4 GRM4 Human Metabotropic glutamate C pKi 4.77 5.51 5.85 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pKi 4.92 5.35 5.92 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 4.94 5.65 6.41 ChEMBL
D1 DRD1 Rat Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 5.0 5.54 6.95 PDSP Ki database
mGlu2 GRM2 Rat Metabotropic glutamate C pKi 5.0 5.48 5.96 PDSP Ki database
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 5.0 5.0 5.0 PDSP Ki database
mGlu8 GRM8 Rat Metabotropic glutamate C pKi 5.0 5.0 5.0 PDSP Ki database
mGlu4 GRM4 Rat Metabotropic glutamate C pKi 5.0 5.0 5.0 PDSP Ki database
mGlu2 GRM2 Human Metabotropic glutamate C pKi 5.4 5.4 5.4 PDSP Ki database
mGlu3 GRM3 Human Metabotropic glutamate C pKi 5.4 5.4 5.4 PDSP Ki database
mGlu7 GRM7 Human Metabotropic glutamate C pKi 5.0 5.0 5.0 PDSP Ki database
mGlu8 GRM8 Human Metabotropic glutamate C pKi 7.7 7.7 7.7 PDSP Ki database
mGlu5 GRM5 Human Metabotropic glutamate C pKi 5.0 5.86 7.57 PDSP Ki database
CB1 CNR1 Human Cannabinoid A pKi 6.0 6.0 6.0 PDSP Ki database
mGlu6 GRM6 Rat Metabotropic glutamate C pKi 5.0 5.0 5.0 PDSP Ki database
mGlu1 GRM1 Human Metabotropic glutamate C pKi 8.18 8.18 8.18 Drug Central
mGlu3 GRM3 Human Metabotropic glutamate C pKi 8.13 8.13 8.13 Drug Central
mGlu4 GRM4 Human Metabotropic glutamate C pKi 8.23 8.23 8.23 Drug Central
mGlu5 GRM5 Human Metabotropic glutamate C pKi 8.19 8.19 8.19 Drug Central
mGlu8 GRM8 Rat Metabotropic glutamate C pKi 8.26 8.26 8.26 Drug Central
mGlu6 GRM6 Human Metabotropic glutamate C pKi 5.0 5.0 5.0 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Human Metabotropic glutamate C pEC50 4.8 4.9 5.0 Guide to Pharmacology
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 4.7 5.05 5.4 Guide to Pharmacology
mGlu3 GRM3 Human Metabotropic glutamate C pEC50 5.3 5.35 5.4 Guide to Pharmacology
mGlu4 GRM4 Human Metabotropic glutamate C pEC50 4.7 5.1 5.5 Guide to Pharmacology
mGlu5 GRM5 Human Metabotropic glutamate C pEC50 5.0 5.25 5.5 Guide to Pharmacology
mGlu6 GRM6 Human Metabotropic glutamate C pEC50 5.0 5.0 5.0 Guide to Pharmacology
mGlu7 GRM7 Human Metabotropic glutamate C pEC50 3.0 3.0 3.0 Guide to Pharmacology
mGlu8 GRM8 Human Metabotropic glutamate C pEC50 4.9 5.25 5.6 Guide to Pharmacology
mGlu8 GRM8 Human Metabotropic glutamate C pIC50 5.0 5.35 5.7 Guide to Pharmacology
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 6.1 6.1 6.1 Guide to Pharmacology
mGlu6 GRM6 Rat Metabotropic glutamate C pEC50 4.4 4.4 4.4 Guide to Pharmacology
mGlu8 GRM8 Mouse Metabotropic glutamate C pEC50 7.66 7.66 7.66 ChEMBL
mGlu6 GRM6 Rat Metabotropic glutamate C pEC50 4.08 4.66 5.12 ChEMBL
mGlu8 GRM8 Rat Metabotropic glutamate C pEC50 4.67 4.87 5.1 ChEMBL
mGlu8 GRM8 Human Metabotropic glutamate C pIC50 8.24 8.24 8.24 ChEMBL
mGlu6 GRM6 Human Metabotropic glutamate C pEC50 4.7 5.0 5.31 ChEMBL
mGlu7 GRM7 Human Metabotropic glutamate C pEC50 5.93 5.93 5.93 ChEMBL
mGlu4 GRM4 Rat Metabotropic glutamate C pEC50 4.9 5.26 5.54 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pEC50 5.29 5.89 7.22 ChEMBL
mGlu3 GRM3 Rat Metabotropic glutamate C pEC50 5.47 6.36 7.24 ChEMBL
mGlu1 GRM1 Rat Metabotropic glutamate C pEC50 4.25 5.08 5.8 ChEMBL
mGlu2 GRM2 Rat Metabotropic glutamate C pEC50 4.74 5.26 6.21 ChEMBL
mGlu1 GRM1 Human Metabotropic glutamate C pEC50 4.72 5.45 5.98 ChEMBL
mGlu4 GRM4 Human Metabotropic glutamate C pEC50 4.7 5.01 5.5 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 4.58 5.38 6.54 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pEC50 4.87 5.3 5.92 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pEC50 4.8 5.26 5.51 ChEMBL
mGlu8 GRM8 Mouse Metabotropic glutamate C pEC50 8.12 8.12 8.12 Drug Central
A3 AA3R Human Adenosine A pIC50 8.21 8.21 8.21 Drug Central
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 8.18 8.18 8.18 Drug Central
mGlu6 GRM6 Human Metabotropic glutamate C pEC50 8.27 8.27 8.27 Drug Central
mGlu7 GRM7 Human Metabotropic glutamate C pEC50 8.23 8.23 8.23 Drug Central
mGlu8 GRM8 Human Metabotropic glutamate C pIC50 8.24 8.24 8.24 Drug Central
mGlu3 GRM3 Rat Metabotropic glutamate C pEC50 8.26 8.26 8.26 Drug Central
mGlu5 GRM5 Rat Metabotropic glutamate C pEC50 8.27 8.27 8.27 Drug Central
mGlu2 GRM2 Rat Metabotropic glutamate C pEC50 8.27 8.27 8.27 Drug Central
mGlu6 GRM6 Rat Metabotropic glutamate C pEC50 8.32 8.32 8.32 Drug Central
mGlu1 GRM1 Rat Metabotropic glutamate C pEC50 8.3 8.3 8.3 Drug Central
mGlu4 GRM4 Rat Metabotropic glutamate C pEC50 8.31 8.31 8.31 Drug Central