loratadine


SMILES CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1
InChIKey JCCNYMKQOSZNPW-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Molecular weight (Da) 382.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations H1

Sankey plot

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pKi 7.43 7.43 7.43 Guide to Pharmacology
H1 HRH1 Rat Histamine A pKi 6.46 6.46 6.46 ChEMBL
H1 HRH1 Guinea pig Histamine A pKd 7.14 7.14 7.14 ChEMBL
H1 HRH1 Human Histamine A pKi 6.38 7.0 7.7 ChEMBL
H1 HRH1 Human Histamine A pKd 6.72 6.72 6.72 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.81 6.81 6.81 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 Drug Central
H1 HRH1 Human Histamine A pKi 8.16 8.16 8.16 Drug Central
H1 HRH1 Guinea pig Histamine A pKd 8.15 8.15 8.15 Drug Central
H1 HRH1 Rat Histamine A pKi 8.19 8.19 8.19 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.7 5.3 5.9 ChEMBL
H1 HRH1 Human Histamine A pIC50 6.54 6.65 6.77 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 6.61 6.61 6.61 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 4.9 5.13 5.4 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.4 4.55 4.7 ChEMBL