lorcaserin


SMILES Clc1ccc2c(c1)[C@@H](C)CNCC2
InChIKey XTTZERNUQAFMOF-QMMMGPOBSA-N

Chemical properties

Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 0
Molecular weight (Da) 195.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 8DPH 8DPF 8DPI
Ligand site mutations 5-HT2C

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.8 6.8 6.8 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.8 6.8 6.8 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.8 7.8 7.8 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.66 7.16 8.89 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.59 7.5 7.82 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.56 7.07 8.89 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.15 8.15 8.15 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.1 8.1 8.1 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 6.8 6.8 6.8 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pEC50 6.0 6.0 6.0 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pEC50 8.1 8.1 8.1 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 8.24 8.24 8.24 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pEC50 6.0 6.4 7.1 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pEC50 6.68 8.12 8.74 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 5.72 6.67 7.49 ChEMBL