LP-211


SMILES N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1
InChIKey BQEDZLDNNBDKDS-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 10
Molecular weight (Da) 466.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.73 6.73 6.73 Guide to Pharmacology
D2 DRD2 Human Dopamine A pKi 6.85 6.85 6.85 Guide to Pharmacology
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 9.24 9.24 9.24 ChEMBL
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 6.75 6.75 6.75 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.82 8.43 9.24 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.2 6.2 6.2 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.42 6.6 6.73 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.62 6.77 6.85 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.73 6.73 6.73 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 6.85 6.85 6.85 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 9.24 9.24 9.24 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.8 5.8 5.8 ChEMBL
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 9.24 9.24 9.24 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Guinea pig 5-Hydroxytryptamine A pEC50 6.22 6.22 6.22 ChEMBL