LY341495


SMILES OC(=O)[C@H]1C[C@@H]1[C@](C(=O)O)(CC1c2ccccc2Oc2c1cccc2)N
InChIKey VLZBRVJVCCNPRJ-KPHUOKFYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 5
Molecular weight (Da) 353.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Structure pdb 7FD9 7MTQ 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 7WI6 7WI8

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Human Metabotropic glutamate C pKi 7.8 7.8 7.8 Guide to Pharmacology
mGlu2 GRM2 Human Metabotropic glutamate C pKi 8.6 8.6 8.6 Guide to Pharmacology
mGlu2 GRM2 Human Metabotropic glutamate C pKd 8.8 8.8 8.8 Guide to Pharmacology
mGlu7 GRM7 Human Metabotropic glutamate C pKi 6.7 6.7 6.7 Guide to Pharmacology
mGlu7 GRM7 Human Metabotropic glutamate C pKd 7.1 7.1 7.1 Guide to Pharmacology
mGlu3 GRM3 Rat Metabotropic glutamate C pKi 8.0 8.0 8.0 Guide to Pharmacology
mGlu3 GRM3 Rat Metabotropic glutamate C pKd 7.3 7.3 7.3 Guide to Pharmacology
mGlu3 GRM3 Human Metabotropic glutamate C pKd 9.1 9.1 9.1 Guide to Pharmacology
mGlu3 GRM3 Human Metabotropic glutamate C pKi 8.9 8.9 8.9 Guide to Pharmacology
mGlu8 GRM8 Human Metabotropic glutamate C pKi 6.77 6.77 6.77 ChEMBL
mGlu7 GRM7 Human Metabotropic glutamate C pKi 6.0 6.0 6.0 ChEMBL
mGlu7 GRM7 Rat Metabotropic glutamate C pKi 6.96 6.96 6.96 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pKi 7.85 8.37 8.89 ChEMBL
mGlu3 GRM3 Rat Metabotropic glutamate C pKi 8.52 8.52 8.52 ChEMBL
mGlu2 GRM2 Rat Metabotropic glutamate C pKi 8.5 8.5 8.5 ChEMBL
mGlu1 GRM1 Human Metabotropic glutamate C pKi 5.17 5.17 5.17 ChEMBL
mGlu4 GRM4 Human Metabotropic glutamate C pKi 4.66 4.66 4.66 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pKi 7.68 8.02 8.37 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 5.09 5.09 5.09 ChEMBL
mGlu2 GRM2 Rat Metabotropic glutamate C pKi 7.7 8.35 9.0 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu4 GRM4 Human Metabotropic glutamate C pIC50 4.7 4.7 4.7 Guide to Pharmacology
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 5.1 5.1 5.1 Guide to Pharmacology
mGlu8 GRM8 Human Metabotropic glutamate C pIC50 6.8 6.8 6.8 Guide to Pharmacology
mGlu6 GRM6 Human Metabotropic glutamate C pEC50 4.5 4.5 4.5 Guide to Pharmacology
mGlu6 GRM6 Rat Metabotropic glutamate C pIC50 5.94 5.94 5.94 ChEMBL
mGlu8 GRM8 Human Metabotropic glutamate C pIC50 6.77 6.77 6.77 ChEMBL
mGlu7 GRM7 Human Metabotropic glutamate C pIC50 5.8 5.9 6.0 ChEMBL
mGlu4 GRM4 Rat Metabotropic glutamate C pIC50 5.58 5.58 5.58 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pIC50 7.85 8.13 8.55 ChEMBL
mGlu3 GRM3 Rat Metabotropic glutamate C pIC50 7.8 7.82 7.85 ChEMBL
mGlu1 GRM1 Rat Metabotropic glutamate C pIC50 5.05 5.05 5.05 ChEMBL
mGlu2 GRM2 Rat Metabotropic glutamate C pIC50 6.7 7.17 7.63 ChEMBL
mGlu1 GRM1 Human Metabotropic glutamate C pIC50 5.11 5.11 5.11 ChEMBL
mGlu4 GRM4 Human Metabotropic glutamate C pIC50 4.66 4.66 4.66 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pIC50 6.7 7.71 8.54 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 4.94 4.94 4.94 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 5.09 5.09 5.09 ChEMBL