mepyramine


SMILES COc1ccc(cc1)CN(c1ccccn1)CCN(C)C
InChIKey YECBIJXISLIIDS-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 7
Molecular weight (Da) 285.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations H1

Sankey plot

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pKi 8.7 8.85 9.0 Guide to Pharmacology
H1 HRH1 Human Histamine A pKi 5.0 8.43 9.28 PDSP Ki database
H1 HRH1 Guinea pig Histamine A pKi 8.9 9.14 9.3 PDSP Ki database
H1 HRH1 Guinea pig Histamine A pKd 8.84 9.12 9.5 ChEMBL
H3 HRH3 Rat Histamine A pKi 5.0 5.03 5.1 PDSP Ki database
H1 HRH1 Human Histamine A pKi 8.35 8.85 9.37 ChEMBL
H1 HRH1 Rat Histamine A pKi 8.35 8.35 8.35 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 5.95 5.95 5.95 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.75 5.75 5.75 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.23 6.23 6.23 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.54 6.54 6.54 ChEMBL
H3 HRH3 Human Histamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.7 5.7 5.7 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 5.97 6.12 6.48 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
H1 HRH1 Mouse Histamine A pKi 8.49 8.49 8.49 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.21 8.21 8.21 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.23 8.23 8.23 Drug Central
H1 HRH1 Human Histamine A pKi 8.04 8.04 8.04 Drug Central
H1 HRH1 Guinea pig Histamine A pKd 8.02 8.02 8.02 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.24 8.24 8.24 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.24 8.24 8.24 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Rat Histamine A pIC50 8.24 8.24 8.24 ChEMBL
H1 HRH1 Guinea pig Histamine A pIC50 7.47 8.14 8.82 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.8 4.88 4.95 ChEMBL
H1 HRH1 Human Histamine A pIC50 6.8 8.51 10.85 ChEMBL
H1 HRH1 Human Histamine A pEC50 8.59 8.59 8.59 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 5.53 5.53 5.53 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 5.55 5.55 5.55 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 5.95 5.95 5.95 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 6.0 6.0 6.0 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.4 4.83 5.3 ChEMBL
A3 AA3R Human Adenosine A pIC50 8.05 8.05 8.05 Drug Central
H1 HRH1 Rat Histamine A pIC50 8.08 8.08 8.08 Drug Central