methoxy-MPEP


SMILES COc1cccc(c1)C#Cc1cccc(n1)C
InChIKey STDHINPODVHROK-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 1
Molecular weight (Da) 223.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Structure pdb 6FFI
Ligand site mutations mGlu1 mGlu5

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 7.96 7.96 7.96 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 8.0 8.0 8.0 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 8.44 8.44 8.44 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 8.38 8.38 8.38 Guide to Pharmacology
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 8.1 8.1 8.1 ChEMBL