MK-212


SMILES Clc1cncc(n1)N1CCNCC1
InChIKey CJAWPFJGFFNXQI-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 1
Molecular weight (Da) 198.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations 5-HT2A 5-HT2C

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.2 6.5 6.8 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.6 6.3 7.0 Guide to Pharmacology
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 6.4 6.4 6.4 Guide to Pharmacology
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.22 5.8 6.75 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.7 6.7 6.7 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.47 5.47 5.47 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 4.68 4.68 4.68 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKd 6.1 6.1 6.1 ChEMBL
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 6.16 6.16 6.16 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.03 5.03 5.03 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.59 6.31 6.82 PDSP Ki database
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 5.0 5.7 6.39 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.99 5.99 5.99 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.21 6.52 6.82 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.05 6.58 7.01 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pEC50 6.79 7.17 7.55 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 5.92 6.15 6.38 ChEMBL