morphine


SMILES O[C@H]1C=C[C@@H]2[C@@]34[C@H]1Oc1c4c(C[C@H]2N(CC3)C)ccc1O
InChIKey BQJCRHHNABKAKU-KBQPJGBKSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 0
Molecular weight (Da) 285.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 8EF6

Sankey plot

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Human Opioid A pKi 6.9 6.9 6.9 Guide to Pharmacology
κ OPRK Human Opioid A pKi 7.3 7.3 7.3 Guide to Pharmacology
μ OPRM Human Opioid A pKi 9.0 9.0 9.0 Guide to Pharmacology
μ OPRM Rat Opioid A pKi 7.9 7.9 7.9 Guide to Pharmacology
κ OPRK Rat Opioid A pKi 6.7 6.85 7.0 Guide to Pharmacology
δ O57585 Zebrafish Opioid A pKi 6.65 6.65 6.65 ChEMBL
NOP OPRX Guinea pig Opioid A pKi 7.86 7.86 7.86 ChEMBL
κ OPRK Rat Opioid A pKi 6.95 7.16 7.57 ChEMBL
κ OPRK Mouse Opioid A pKi 5.81 6.16 6.52 ChEMBL
μ OPRM Mouse Opioid A pKi 8.34 8.73 8.92 ChEMBL
δ OPRD Mouse Opioid A pKi 7.0 7.0 7.0 ChEMBL
κ OPRK Guinea pig Opioid A pKi 5.19 6.9 7.62 ChEMBL
μ OPRM Rat Opioid A pKi 6.93 8.34 9.11 ChEMBL
κ OPRK Human Opioid A pKi 5.72 7.12 8.16 ChEMBL
δ OPRD Human Opioid A pKi 6.15 6.61 7.29 ChEMBL
μ OPRM Human Opioid A pKi 7.42 8.57 9.85 ChEMBL
μ OPRM Bovine Opioid A pKi 8.03 8.03 8.03 Drug Central
δ OPRD Human Opioid A pKi 8.18 8.18 8.18 Drug Central
κ OPRK Human Opioid A pKi 8.16 8.16 8.16 Drug Central
δ OPRD Mouse Opioid A pKi 8.15 8.15 8.15 Drug Central
μ OPRM Rat Opioid A pKi 8.04 8.04 8.04 Drug Central
κ OPRK Mouse Opioid A pKi 8.19 8.19 8.19 Drug Central
κ OPRK Rat Opioid A pKi 8.12 8.12 8.12 Drug Central
κ OPRK Guinea pig Opioid A pKi 8.12 8.12 8.12 Drug Central
μ OPRM Mouse Opioid A pKi 8.05 8.05 8.05 Drug Central
δ OPRD Rat Opioid A pKi 8.06 8.06 8.06 Drug Central
μ OPRM Bovine Opioid A pKi 8.6 8.98 9.3 ChEMBL
NOP OPRX Guinea pig Opioid A pKi 8.1 8.1 8.1 Drug Central
δ O57585 Zebrafish Opioid A pKi 8.18 8.18 8.18 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
κ OPRK Mouse Opioid A pIC50 6.84 6.84 6.84 ChEMBL
κ OPRK Mouse Opioid A pEC50 6.4 6.4 6.4 ChEMBL
μ OPRM Mouse Opioid A pIC50 5.85 7.39 8.9 ChEMBL
μ OPRM Mouse Opioid A pEC50 6.4 6.98 7.52 ChEMBL
δ OPRD Mouse Opioid A pIC50 5.8 6.27 6.81 ChEMBL
κ OPRK Guinea pig Opioid A pIC50 5.62 6.63 8.74 ChEMBL
μ OPRM Rat Opioid A pIC50 5.01 8.25 9.85 ChEMBL
μ OPRM Rat Opioid A pEC50 6.71 6.97 7.67 ChEMBL
κ OPRK Human Opioid A pIC50 5.77 6.21 6.66 ChEMBL
κ OPRK Human Opioid A pEC50 6.32 6.36 6.48 ChEMBL
δ OPRD Human Opioid A pIC50 6.37 6.64 6.82 ChEMBL
δ OPRD Human Opioid A pEC50 6.11 6.72 7.81 ChEMBL
μ OPRM Human Opioid A pIC50 6.39 8.07 9.24 ChEMBL
μ OPRM Human Opioid A pEC50 6.3 7.35 8.43 ChEMBL
μ OPRM Human Opioid A pEC50 8.1 8.1 8.1 Drug Central