otenzepad


SMILES CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC
InChIKey UBRKDAVQCKZSPO-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 421.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations M1 M2

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Human Acetylcholine (muscarinic) A pKd 6.2 6.2 6.2 Guide to Pharmacology
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 6.1 6.1 6.1 Guide to Pharmacology
M4 ACM4 Human Acetylcholine (muscarinic) A pKd 7.0 7.0 7.0 Guide to Pharmacology
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 6.5 6.5 6.5 Guide to Pharmacology
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 4.6 5.95 7.3 Guide to Pharmacology
M5 ACM5 Rat Acetylcholine (muscarinic) A pKi 5.7 5.7 5.7 Guide to Pharmacology
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 5.9 6.1 6.3 Guide to Pharmacology
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 6.0 6.0 6.0 Guide to Pharmacology
M1 ACM1 Fruit fly Acetylcholine (muscarinic) A pKi 5.86 5.88 5.91 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 6.39 6.39 6.39 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 5.68 5.68 5.68 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 7.09 7.19 7.28 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 6.27 6.51 6.75 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.7 6.95 7.2 Guide to Pharmacology
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 5.6 5.6 5.6 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M3 ACM3 Rat Acetylcholine (muscarinic) A pIC50 5.0 5.15 5.22 ChEMBL
M2 ACM2 Rat Acetylcholine (muscarinic) A pIC50 6.4 6.85 7.3 ChEMBL