oxotremorine-M


SMILES O=C1CCCN1CC#CC[N+](C)(C)C
InChIKey CANZROMYQDHYHR-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 2
Molecular weight (Da) 195.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations M1 M2 M3

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 5.1 5.1 5.1 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 4.9 4.9 4.9 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKd 8.7 8.7 8.7 Guide to Pharmacology
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 5.1 5.1 5.1 Guide to Pharmacology
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 5.2 5.2 5.2 Guide to Pharmacology
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 5.82 7.05 9.11 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 5.92 5.92 5.92 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.97 6.97 6.97 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 4.69 4.69 4.69 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 5.6 5.6 5.6 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Mouse Acetylcholine (muscarinic) A pEC50 6.16 6.16 6.16 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 8.0 8.0 8.0 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pEC50 5.64 5.64 5.64 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pEC50 5.13 5.13 5.13 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pEC50 5.75 5.75 5.75 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 5.2 5.63 6.5 ChEMBL