perphenazine


SMILES OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2
InChIKey RGCVKNLCSQQDEP-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 403.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Sankey plot

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.2 8.2 8.2 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.9 6.9 6.9 Guide to Pharmacology
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 7.1 7.1 7.1 Guide to Pharmacology
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.2 7.2 7.2 Guide to Pharmacology
H1 HRH1 Human Histamine A pKi 8.1 8.1 8.1 Guide to Pharmacology
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 7.8 7.8 7.8 Guide to Pharmacology
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.6 7.6 7.6 Guide to Pharmacology
D2 DRD2 Rat Dopamine A pKi 8.89 9.04 9.2 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 8.85 9.26 9.8 PDSP Ki database
H1 HRH1 Human Histamine A pKi 8.08 8.09 8.1 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 7.36 7.44 7.52 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.88 6.88 6.88 PDSP Ki database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 7.77 7.79 7.8 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.6 7.62 7.64 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.25 8.25 8.25 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 6.88 7.09 7.3 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 8.96 9.52 9.89 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 7.32 7.59 7.77 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 5.73 5.73 5.73 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 8.0 8.0 8.0 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.7 6.04 6.38 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.64 7.64 7.64 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 6.98 6.98 6.98 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 7.07 7.07 7.07 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 7.77 7.77 7.77 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 5.77 5.77 5.77 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 5.54 5.54 5.54 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.22 8.22 8.22 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.08 8.08 8.08 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.16 8.16 8.16 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.12 8.12 8.12 Drug Central
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.12 8.12 8.12 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.24 8.24 8.24 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 8.1 8.1 8.1 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.21 8.21 8.21 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.15 8.15 8.15 Drug Central
D2 DRD2 Human Dopamine A pKi 8.03 8.03 8.03 Drug Central
D3 DRD3 Human Dopamine A pKi 8.02 8.02 8.02 Drug Central
D4 DRD4 Human Dopamine A pKi 8.12 8.12 8.12 Drug Central
H1 HRH1 Human Histamine A pKi 8.09 8.09 8.09 Drug Central
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 8.11 8.11 8.11 Drug Central
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.64 7.64 7.64 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.09 6.09 6.09 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 8.16 8.16 8.16 Drug Central
D2 DRD2 Human Dopamine A pKi 8.85 9.22 9.59 Guide to Pharmacology
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.12 8.12 8.12 Drug Central
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 5.73 5.73 5.73 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.7 4.83 4.95 ChEMBL
D2 DRD2 Human Dopamine A pIC50 9.52 9.52 9.52 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 4.6 4.8 5.0 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.8 4.8 4.8 ChEMBL