(R)-SKF-38393


SMILES Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2
InChIKey JUDKOGFHZYMDMF-CQSZACIVSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 1
Molecular weight (Da) 255.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations D1 D2 D5

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D5 DRD5 Human Dopamine A pKi 6.61 7.51 9.3 ChEMBL
D1 DRD1 Rat Dopamine A pKi 7.19 7.28 7.46 ChEMBL
D2 DRD2 Rat Dopamine A pKi 5.16 5.29 5.54 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.5 7.52 9.0 ChEMBL
D1 DRD1 Human Dopamine A pKd 6.82 6.82 6.82 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.02 5.18 5.33 ChEMBL
D2 DRD2 Human Dopamine A pKd 5.02 5.02 5.02 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Goldfish Dopamine A pEC50 6.02 6.02 6.02 ChEMBL
D1 DRD1 Rat Dopamine A pEC50 7.0 7.0 7.0 ChEMBL
D1 DRD1 Rat Dopamine A pIC50 7.3 7.38 7.46 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 5.43 5.43 5.43 ChEMBL
D1 DRD1 Human Dopamine A pEC50 6.41 7.1 7.52 ChEMBL