GPCRdb

DEXPROPRANOLOL

Agent/drug
Bioactivity

DEXPROPRANOLOL

SMILES	CC(C)NC[C@@H](O)COc1cccc2ccccc12
InChIKey	AQHHHDLHHXJYJD-CQSZACIVSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	2
Rotatable bonds	6
Molecular weight (Da)	259.2

Database connections

ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	β₁ β₂

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

β₁	ADRB1	Human	Adrenoceptors	A	pKi	6.67	6.67	6.67	ChEMBL
β₁	ADRB1	Rat	Adrenoceptors	A	pKi	7.09	7.09	7.09	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	7.28	7.28	7.28	ChEMBL
β₂	ADRB2	Rat	Adrenoceptors	A	pKi	7.36	7.36	7.36	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.55	5.66	5.77	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.15	5.15	5.15	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.55	6.55	6.55	ChEMBL

Showing 1 to 7 of 7 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

β₁	ADRB1	Human	Adrenoceptors	A	pIC50	6.43	6.43	6.43	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pIC50	7.12	7.12	7.12	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	5.31	6.04	6.77	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	6.31	6.31	6.31	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.36	6.36	6.36	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	6.35	6.45	6.55	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	5.30	5.30	5.30	ChEMBL

Showing 1 to 7 of 7 entries

DEXPROPRANOLOL

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV 0

Database connections

ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	β₁ β₂

Compound is not listed as a drug.