PGE1


SMILES CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O
InChIKey GMVPRGQOIOIIMI-DWKJAMRDSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 13
Molecular weight (Da) 354.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Endogenous
Approved drug Yes

Database connections

Sankey plot

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
DP1 PD2R Human Prostanoid A pKi 7.3 7.3 7.3 Guide to Pharmacology
EP1 PE2R1 Human Prostanoid A pKi 6.8 6.8 6.8 Guide to Pharmacology
EP2 PE2R2 Human Prostanoid A pKi 8.04 8.04 8.04 Guide to Pharmacology
EP1 PE2R1 Mouse Prostanoid A pKi 7.4 7.4 7.4 Guide to Pharmacology
EP3 PE2R3 Rat Prostanoid A pKi 9.0 9.0 9.0 Guide to Pharmacology
EP3 PE2R3 Mouse Prostanoid A pKi 9.0 9.0 9.0 Guide to Pharmacology
EP1 PE2R1 Rat Prostanoid A pKi 7.0 7.0 7.0 Guide to Pharmacology
EP2 PE2R2 Rat Prostanoid A pKi 8.0 8.0 8.0 Guide to Pharmacology
EP2 PE2R2 Mouse Prostanoid A pKi 8.0 8.0 8.0 Guide to Pharmacology
IP PI2R Human Prostanoid A pKi 6.5 6.66 6.82 Guide to Pharmacology
EP4 PE2R4 Rat Prostanoid A pKi 9.2 9.2 9.2 Guide to Pharmacology
EP4 PE2R4 Mouse Prostanoid A pKi 8.7 8.7 8.7 Guide to Pharmacology
IP PI2R Mouse Prostanoid A pKi 7.5 7.5 7.5 Guide to Pharmacology
EP1 PE2R1 Mouse Prostanoid A pKi 7.0 7.63 8.22 ChEMBL
EP2 PE2R2 Mouse Prostanoid A pKi 7.06 7.38 7.66 ChEMBL
EP4 PE2R4 Mouse Prostanoid A pKi 8.48 8.49 8.51 ChEMBL
EP3 PE2R3 Mouse Prostanoid A pKi 8.3 8.3 8.3 ChEMBL
EP1 PE2R1 Mouse Prostanoid A pKi 7.44 7.44 7.44 PDSP Ki database
IP PI2R Mouse Prostanoid A pKi 6.86 7.17 7.48 PDSP Ki database
EP2 PE2R2 Mouse Prostanoid A pKi 8.0 8.0 8.0 PDSP Ki database
EP4 PE2R4 Mouse Prostanoid A pKi 8.68 8.68 8.68 PDSP Ki database
EP3 PE2R3 Bovine Prostanoid A pKi 8.4 8.55 8.7 PDSP Ki database
FP PF2R Bovine Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
TP TA2R Mouse Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
DP1 PD2R Rat Prostanoid A pKi 5.43 5.43 5.43 PDSP Ki database
IP PI2R Human Prostanoid A pKi 6.86 6.86 6.86 PDSP Ki database
EP3 PE2R3 Mouse Prostanoid A pKi 8.08 8.08 8.08 Drug Central
EP1 PE2R1 Rat Prostanoid A pKi 8.15 8.15 8.15 Drug Central
EP2 PE2R2 Rat Prostanoid A pKi 8.1 8.1 8.1 Drug Central
EP4 PE2R4 Rat Prostanoid A pKi 8.04 8.04 8.04 Drug Central
EP4 PE2R4 Mouse Prostanoid A pKi 8.07 8.07 8.07 Drug Central
IP PI2R Mouse Prostanoid A pKi 8.12 8.12 8.12 Drug Central
EP2 PE2R2 Mouse Prostanoid A pKi 8.12 8.12 8.12 Drug Central
EP4 PE2R4 Human Prostanoid A pKi 8.8 8.8 8.8 Guide to Pharmacology
IP PI2R Human Prostanoid A pKi 6.82 6.82 6.82 ChEMBL
EP1 PE2R1 Mouse Prostanoid A pKi 8.09 8.09 8.09 Drug Central
EP3 PE2R3 Mouse Prostanoid A pKi 8.96 8.96 8.96 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP3 PE2R3 Rat Prostanoid A pEC50 9.35 9.35 9.35 Guide to Pharmacology
EP2 PE2R2 Mouse Prostanoid A pEC50 8.59 8.59 8.59 ChEMBL
EP4 PE2R4 Mouse Prostanoid A pEC50 8.44 8.55 8.6 ChEMBL
DP1 PD2R Human Prostanoid A pEC50 8.14 8.14 8.14 Drug Central
EP1 PE2R1 Human Prostanoid A pEC50 8.17 8.17 8.17 Drug Central
EP2 PE2R2 Human Prostanoid A pEC50 8.1 8.1 8.1 Drug Central
EP3 PE2R3 Human Prostanoid A pEC50 8.05 8.05 8.05 Drug Central
EP4 PE2R4 Human Prostanoid A pEC50 8.06 8.06 8.06 Drug Central
IP PI2R Human Prostanoid A pEC50 8.12 8.12 8.12 Drug Central
EP3 PE2R3 Rat Prostanoid A pEC50 8.03 8.03 8.03 Drug Central
EP4 PE2R4 Human Prostanoid A pEC50 9.51 9.51 9.51 Guide to Pharmacology
IP PI2R Human Prostanoid A pIC50 5.85 5.85 5.85 ChEMBL
IP PI2R Human Prostanoid A pEC50 8.74 8.74 8.74 ChEMBL