pipamperone


SMILES O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N
InChIKey AXKPFOAXAHJUAG-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 375.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Sankey plot

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.6 5.6 5.6 Guide to Pharmacology
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.2 6.2 6.2 Guide to Pharmacology
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.8 6.8 6.8 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.3 8.3 8.3 Guide to Pharmacology
H1 HRH1 Human Histamine A pKi 5.6 5.6 5.6 Guide to Pharmacology
5-HT7 5HT7R Mouse 5-Hydroxytryptamine A pKi 6.82 6.82 6.82 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.59 5.59 5.59 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.43 5.43 5.43 PDSP Ki database
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 6.92 6.92 6.92 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.56 5.56 5.56 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.8 6.8 6.8 PDSP Ki database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.19 6.19 6.19 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 5.61 5.61 5.61 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 7.03 7.03 7.03 PDSP Ki database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 PDSP Ki database
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.14 8.21 8.27 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 6.07 6.07 6.07 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 7.46 7.46 7.46 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 6.92 6.94 6.96 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 6.6 6.6 6.6 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 6.54 6.54 6.54 PDSP Ki database
β1 ADRB1 Human Adrenoceptors A pKi 5.3 5.3 5.3 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 5.3 5.3 5.3 PDSP Ki database
H1 HRH1 Human Histamine A pKi 5.62 5.62 5.62 PDSP Ki database
D1 DRD1 Bovine Dopamine A pKi 5.31 5.31 5.31 PDSP Ki database
D2 DRD2 Bovine Dopamine A pKi 7.5 7.5 7.51 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.21 8.21 8.21 Drug Central
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 Drug Central
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 8.28 8.28 8.28 Drug Central
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 8.28 8.28 8.28 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.08 8.08 8.08 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.14 8.14 8.14 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.18 8.18 8.18 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.22 8.22 8.22 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.13 8.13 8.13 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.18 8.18 8.18 Drug Central
β1 ADRB1 Human Adrenoceptors A pKi 8.28 8.28 8.28 Drug Central
D2 DRD2 Human Dopamine A pKi 8.16 8.16 8.16 Drug Central
D3 DRD3 Human Dopamine A pKi 8.18 8.18 8.18 Drug Central
H1 HRH1 Human Histamine A pKi 8.25 8.25 8.25 Drug Central
5-HT1D F1MMU1 Bovine 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 6.24 6.24 6.24 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.32 7.32 7.32 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.64 6.64 6.64 PDSP Ki database
μ OPRM Rat Opioid A pKi 6.0 6.0 6.0 PDSP Ki database
CCK2 GASR Rat Cholecystokinin A pKi 6.0 6.0 6.0 PDSP Ki database
PAF PTAFR Human Platelet-activating factor A pKi 6.0 6.0 6.0 PDSP Ki database
TP TA2R Human Prostanoid A pKi 6.0 6.0 6.0 PDSP Ki database
κ OPRK Guinea pig Opioid A pKi 6.0 6.0 6.0 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.25 8.25 8.25 Drug Central
β2 ADRB2 Human Adrenoceptors A pKi 8.28 8.28 8.28 Drug Central
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.92 8.92 8.92 PDSP Ki database
δ OPRD Mouse Opioid A pKi 6.0 6.0 6.0 PDSP Ki database
H1 HRH1 Guinea pig Histamine A pKi 5.3 5.3 5.3 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database