prochlorperazine


SMILES CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2
InChIKey WIKYUJGCLQQFNW-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight (Da) 373.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Sankey plot

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Human Dopamine A pKi 7.11 7.11 7.11 Guide to Pharmacology
D2 DRD2 Human Dopamine A pKi 8.44 8.44 8.44 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 8.35 8.35 8.35 Guide to Pharmacology
D4 DRD4 Human Dopamine A pKi 6.09 6.09 6.09 Guide to Pharmacology
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 6.91 7.0 7.1 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.92 5.92 5.92 ChEMBL
α1B ADA1B Rat Adrenoceptors A pKi 7.31 7.31 7.31 ChEMBL
D2 DRD2 Human Dopamine A pKi 8.15 8.77 9.7 PDSP Ki database
5-HT4 5HT4R Guinea pig 5-Hydroxytryptamine A pKi 6.71 6.71 6.71 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 7.89 7.89 7.89 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.47 8.61 8.74 PDSP Ki database
H1 HRH1 Human Histamine A pKi 7.72 7.72 7.72 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 7.8 7.8 7.8 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 8.32 8.32 8.32 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.8 6.8 6.8 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.92 7.92 7.92 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 6.72 6.72 6.72 ChEMBL
H1 HRH1 Human Histamine A pKi 8.55 8.55 8.55 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 6.49 6.49 6.49 ChEMBL
D4 DRD4 Human Dopamine A pKi 6.09 6.09 6.09 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.26 6.26 6.26 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 7.2 7.2 7.2 ChEMBL
D1 DRD1 Human Dopamine A pKi 7.11 7.11 7.11 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.91 6.91 6.91 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.19 7.19 7.19 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 5.96 5.96 5.96 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.39 7.39 7.39 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 6.61 6.61 6.61 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.35 8.35 8.35 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.7 8.7 8.7 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.91 6.91 6.91 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 8.44 8.44 8.44 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.23 5.23 5.23 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.82 7.98 8.14 PDSP Ki database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 6.83 6.83 6.83 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 6.71 6.71 6.71 PDSP Ki database
5-HT7 5HT7R Guinea pig 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 8.3 8.32 8.33 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 5.95 7.3 8.27 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.83 6.83 6.83 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.17 5.17 5.17 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 6.11 6.11 6.11 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 5.85 5.85 5.85 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.28 8.28 8.28 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.11 8.11 8.11 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.14 8.14 8.14 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.16 8.16 8.16 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.16 8.16 8.16 Drug Central
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.18 8.18 8.18 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.23 8.23 8.23 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.19 8.19 8.19 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.17 8.17 8.17 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 8.12 8.12 8.12 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 8.1 8.1 8.1 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.14 8.14 8.14 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.08 8.08 8.08 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.1 8.1 8.1 Drug Central
D1 DRD1 Human Dopamine A pKi 8.15 8.15 8.15 Drug Central
D2 DRD2 Human Dopamine A pKi 8.06 8.06 8.06 Drug Central
D3 DRD3 Human Dopamine A pKi 8.06 8.06 8.06 Drug Central
D4 DRD4 Human Dopamine A pKi 8.14 8.14 8.14 Drug Central
H1 HRH1 Human Histamine A pKi 8.11 8.11 8.11 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.17 8.17 8.17 Drug Central
5-HT4 5HT4R Guinea pig 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 Drug Central
α1B ADA1B Rat Adrenoceptors A pKi 8.14 8.14 8.14 Drug Central
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 8.23 8.23 8.23 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pIC50 5.58 5.58 5.58 ChEMBL
α1B ADA1B Rat Adrenoceptors A pIC50 7.05 7.05 7.05 ChEMBL
5-HT4 5HT4R Guinea pig 5-Hydroxytryptamine A pIC50 5.93 5.93 5.93 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 7.5 7.5 7.5 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 5.25 5.25 5.25 ChEMBL
α1D ADA1D Human Adrenoceptors A pIC50 7.47 7.47 7.47 ChEMBL
α2B ADA2B Human Adrenoceptors A pIC50 8.0 8.0 8.0 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pIC50 6.66 6.66 6.66 ChEMBL
α2C ADA2C Human Adrenoceptors A pIC50 7.09 7.09 7.09 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pIC50 5.87 5.87 5.87 ChEMBL
H1 HRH1 Human Histamine A pIC50 7.62 7.62 7.62 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pIC50 5.82 5.82 5.82 ChEMBL
D4 DRD4 Human Dopamine A pIC50 5.64 5.64 5.64 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 6.02 6.02 6.02 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 6.77 6.77 6.77 ChEMBL
D1 DRD1 Human Dopamine A pIC50 6.81 6.81 6.81 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pIC50 6.57 6.57 6.57 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 6.99 6.99 6.99 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pIC50 5.51 5.51 5.51 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 7.11 7.11 7.11 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pIC50 5.99 5.99 5.99 ChEMBL
D3 DRD3 Human Dopamine A pIC50 7.89 7.89 7.89 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 8.15 8.15 8.15 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 4.6 4.67 4.8 ChEMBL
D2 DRD2 Human Dopamine A pIC50 7.96 7.96 7.96 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 8.22 8.22 8.22 Drug Central
α1A ADA1A Rat Adrenoceptors A pIC50 8.13 8.13 8.13 Drug Central
TSH TSHR Human Glycoprotein hormone A Potency 5.5 5.5 5.5 ChEMBL