Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Unit Assay Type Assay Description Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles
CHEMBL7303 acm3_human Human Yes 7.0 EC50 = 100 Funct
Contraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropineContraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropine
155 2 0 3 0.3 CN1CCC=C(C1)C(=O)OC
CHEMBL20835 acm3_mouse Mouse Yes 5.0 EC50 = 10000 Funct
Tested against Muscarinic acetylcholine receptor M3 expressed in A9 L cell lineTested against Muscarinic acetylcholine receptor M3 expressed in A9 L cell line
169 2 0 3 0.7 CC(=O)OC1CN2CCC1CC2
CHEMBL485913 acm3_human Human No 7.0 EC50 = 113 Funct
Agonist activity at muscarinic M3 receptorAgonist activity at muscarinic M3 receptor
387 6 2 5 1.9 C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CCOC(=O)N
CHEMBL491209 acm3_human Human No 7.0 EC50 = 113 Funct
Agonist activity at muscarinic M3 receptorAgonist activity at muscarinic M3 receptor
372 4 1 4 2.8 CCOC(=O)N1CCC(CC1)N2CCC(CC2)N3C4=CC=CC=C4NC3=O
CHEMBL485913 acm3_human Human No 7.0 EC50 = 113 Funct
Agonist activity at muscarinic M3 receptorAgonist activity at muscarinic M3 receptor
387 6 2 5 1.9 C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CCOC(=O)N
CHEMBL491209 acm3_human Human No 7.0 EC50 = 113 Funct
Agonist activity at muscarinic M3 receptorAgonist activity at muscarinic M3 receptor
372 4 1 4 2.8 CCOC(=O)N1CCC(CC1)N2CCC(CC2)N3C4=CC=CC=C4NC3=O
CHEMBL134641 acm3_human Human Yes 6.9 EC50 = 117 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
193 2 0 4 1.0 CON=C(C#N)C1CN2CCC1CC2
CHEMBL134641 acm3_human Human Yes 6.9 EC50 = 117 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
193 2 0 4 1.0 CON=C(C#N)C1CN2CCC1CC2
CHEMBL978 acm3_rat Rat Yes 6.9 EC50 = 120 Funct
Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M3Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M3
160 4 0 2 0.6 CC(C[N+](C)(C)C)OC(=O)C
CHEMBL7303 acm3_mouse Mouse Yes 4.9 EC50 = 12000 Funct
Tested against Muscarinic acetylcholine receptor M3 expressed in A9 L cell lineTested against Muscarinic acetylcholine receptor M3 expressed in A9 L cell line
155 2 0 3 0.3 CN1CCC=C(C1)C(=O)OC
CHEMBL1223804 acm3_human Human No 6.9 EC50 = 125.9 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
371 4 0 3 3.6 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C(=O)CC4=C3C=C(C=C4)C
CHEMBL1223804 acm3_human Human No 6.9 EC50 = 125.9 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
371 4 0 3 3.6 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C(=O)CC4=C3C=C(C=C4)C
CHEMBL1223864 acm3_human Human No 5.9 EC50 = 1258.9 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
437 5 0 6 2.9 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)C)OC3=O
CHEMBL1223864 acm3_human Human No 5.9 EC50 = 1258.9 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
437 5 0 6 2.9 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)C)OC3=O
CHEMBL69306 acm3_human Human No 6.9 EC50 = 130 Funct
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M3 determined by receptor selection and amplification technology (R-SAT)In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M3 determined by receptor selection and amplification technology (R-SAT)
192 2 1 4 0.4 C#CCOC1=NOC2=C1CNCCC2
CHEMBL12587 acm3_rat Rat Yes 6.9 EC50 = 130 Funct
Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M3Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M3
174 2 1 2 0.1 CC1C(CC(O1)C[N+](C)(C)C)O
CHEMBL305264 acm3_human Human No 6.9 EC50 = 140 Funct
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M3 determined by receptor selection and amplification technology (R-SAT)In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M3 determined by receptor selection and amplification technology (R-SAT)
196 2 1 4 1.1 CC(C)OC1=NOC2=C1CNCCC2
CHEMBL85678 acm3_human Human No 4.8 EC50 = 14600 Funct
Effective concentration for MIPA (muscarinic-stimulated inositol phosphate accumulation) activity in SK-N-SH neuroblastoma cells expressing human muscarinic M3 receptorEffective concentration for MIPA (muscarinic-stimulated inositol phosphate accumulation) activity in SK-N-SH neuroblastoma cells expressing human muscarinic M3 receptor
140 1 0 3 0.6 CON=C1CN2CCC1C2
CHEMBL1223862 acm3_human Human No 5.8 EC50 = 1584.9 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
389 5 0 5 3.6 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)OC)OC3=O
CHEMBL1223862 acm3_human Human No 5.8 EC50 = 1584.9 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
389 5 0 5 3.6 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)OC)OC3=O
CHEMBL313918 acm3_human Human No 4.8 EC50 = 16400 Funct
Effective concentration for MIPA (muscarinic-stimulated inositol phosphate accumulation) activity in SK-N-SH neuroblastoma cells expressing human muscarinic M3 receptorEffective concentration for MIPA (muscarinic-stimulated inositol phosphate accumulation) activity in SK-N-SH neuroblastoma cells expressing human muscarinic M3 receptor
202 2 0 3 1.4 C#CCC#CCON=C1CN2CCC1C2
CHEMBL1223861 acm3_human Human No 5.7 EC50 = 1995.3 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
390 4 0 5 4.1 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C(=CC(=C4)C)F)OC3=O
CHEMBL1223806 acm3_human Human No 5.7 EC50 = 1995.3 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
358 3 0 4 3.6 CC1=CC2=C(C=C1)OC(=O)N2C3CCN(CC3)C4(CCC(CC4)OC)C
CHEMBL1223861 acm3_human Human No 5.7 EC50 = 1995.3 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
390 4 0 5 4.1 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C(=CC(=C4)C)F)OC3=O
CHEMBL1223806 acm3_human Human No 5.7 EC50 = 1995.3 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
358 3 0 4 3.6 CC1=CC2=C(C=C1)OC(=O)N2C3CCN(CC3)C4(CCC(CC4)OC)C
CHEMBL3329755 acm3_human Human Yes 5.7 EC50 = 2100 Funct
Activity at human muscarinic acetylcholine receptor subtype 3 expressed in CHO cells by calcium mobilization assayActivity at human muscarinic acetylcholine receptor subtype 3 expressed in CHO cells by calcium mobilization assay
495 6 1 8 3.4 CCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL3329755 acm3_human Human Yes 5.7 EC50 = 2100 Funct
Activity at human muscarinic acetylcholine receptor subtype 3 expressed in CHO cells by calcium mobilization assayActivity at human muscarinic acetylcholine receptor subtype 3 expressed in CHO cells by calcium mobilization assay
495 6 1 8 3.4 CCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL503735 acm3_human Human Yes 5.7 EC50 = 2200 Funct
Agonist activity at human muscarinic M3 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M3 expressed in CHO cells assessed as stimulation of calcium mobilization
340 2 0 5 3.9 C1=CC2=C(C(=C1)Cl)N(C(=O)C2=O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL503735 acm3_human Human Yes 5.7 EC50 = 2200 Funct
Agonist activity at human muscarinic M3 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M3 expressed in CHO cells assessed as stimulation of calcium mobilization
340 2 0 5 3.9 C1=CC2=C(C(=C1)Cl)N(C(=O)C2=O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL503735 acm3_human Human Yes 5.7 EC50 = 2220 Funct
Activation of human muscarinic M3 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M3 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
340 2 0 5 3.9 C1=CC2=C(C(=C1)Cl)N(C(=O)C2=O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL503735 acm3_human Human Yes 5.7 EC50 = 2220 Funct
Activation of human muscarinic M3 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M3 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
340 2 0 5 3.9 C1=CC2=C(C(=C1)Cl)N(C(=O)C2=O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL1223863 acm3_human Human No 5.6 EC50 = 2511.9 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
383 4 0 5 3.4 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)C#N)OC3=O
CHEMBL1223753 acm3_human Human Yes 5.6 EC50 = 2511.9 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
333 2 1 4 2.2 CC1=CC2=C(C=C1F)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL1223753 acm3_human Human Yes 5.6 EC50 = 2511.9 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
333 2 1 4 2.2 CC1=CC2=C(C=C1F)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL1223863 acm3_human Human No 5.6 EC50 = 2511.9 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
383 4 0 5 3.4 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)C#N)OC3=O
CHEMBL1223753 acm3_human Human Yes 5.6 EC50 = 2511.9 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
333 2 1 4 2.2 CC1=CC2=C(C=C1F)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL1223753 acm3_human Human Yes 5.6 EC50 = 2511.9 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
333 2 1 4 2.2 CC1=CC2=C(C=C1F)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL2111051 acm3_human Human Yes 5.6 EC50 = 2696 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
165 2 0 2 0.8 C#CCOC1CN2CCC1CC2
CHEMBL2111051 acm3_human Human Yes 5.6 EC50 = 2696 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
165 2 0 2 0.8 C#CCOC1CN2CCC1CC2
CHEMBL1084941 acm3_human Human No 5.6 EC50 = 2710 Funct
PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M3. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with human M3 (Class of assay: confirmatory) PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M3. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with human M3 (Class of assay: confirmatory)
317 3 0 3 2.3 CN1C=C(C=N1)C2=CC=C(C=C2)CN3C4=CC=CC=C4C(=O)C3=O
CHEMBL1084941 acm3_human Human No 5.6 EC50 = 2710 Funct
PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M3. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with human M3 (Class of assay: confirmatory) PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M3. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with human M3 (Class of assay: confirmatory)
317 3 0 3 2.3 CN1C=C(C=N1)C2=CC=C(C=C2)CN3C4=CC=CC=C4C(=O)C3=O
CHEMBL12378 acm3_mouse Mouse Yes 5.6 EC50 = 2800 Funct
Tested against Muscarinic acetylcholine receptor M3 expressed in A9 L cell lineTested against Muscarinic acetylcholine receptor M3 expressed in A9 L cell line
179 1 0 4 0.8 CC1=NOC(=N1)C2=CCCN(C2)C
CHEMBL64000 acm3_rat Rat No 8.4 EC50 = 3.6 Funct
Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M3Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M3
169 2 1 3 0.9 CC(=O)OC1CC2CCCC1N2
CHEMBL268808 acm3_human Human Yes 6.5 EC50 = 300 Funct
Contraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropineContraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropine
141 2 1 3 0.1 COC(=O)C1=CCCNC1
CHEMBL3329755 acm3_rat Rat Yes 5.5 EC50 = 3100 Funct
Activity at rat muscarinic acetylcholine receptor subtype 3 expressed in CHO cells by calcium mobilization assayActivity at rat muscarinic acetylcholine receptor subtype 3 expressed in CHO cells by calcium mobilization assay
495 6 1 8 3.4 CCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL3329755 acm3_rat Rat Yes 5.5 EC50 = 3100 Funct
Activity at rat muscarinic acetylcholine receptor subtype 3 expressed in CHO cells by calcium mobilization assayActivity at rat muscarinic acetylcholine receptor subtype 3 expressed in CHO cells by calcium mobilization assay
495 6 1 8 3.4 CCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL1223805 acm3_human Human No 6.5 EC50 = 316.2 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
357 3 0 3 3.3 CC1=CC2=C(CC(=O)N2C3CCN(CC3)C4(CCC(CC4)OC)C)C=C1
CHEMBL1223805 acm3_human Human No 6.5 EC50 = 316.2 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
357 3 0 3 3.3 CC1=CC2=C(CC(=O)N2C3CCN(CC3)C4(CCC(CC4)OC)C)C=C1
CHEMBL1223939 acm3_human Human No 5.5 EC50 = 3162.3 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
451 6 0 6 3.4 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)C)OC3=O
CHEMBL1223939 acm3_human Human No 5.5 EC50 = 3162.3 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
451 6 0 6 3.4 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)C)OC3=O
CHEMBL7303 acm3_human Human Yes 6.5 EC50 = 340 Funct
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M3 determined by receptor selection and amplification technology (R-SAT)In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M3 determined by receptor selection and amplification technology (R-SAT)
155 2 0 3 0.3 CN1CCC=C(C1)C(=O)OC
CHEMBL1223938 acm3_human Human No 6.4 EC50 = 398.1 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
451 6 0 6 3.3 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)CC)OC3=O
CHEMBL1223938 acm3_human Human No 6.4 EC50 = 398.1 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
451 6 0 6 3.3 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)CC)OC3=O
CHEMBL1223941 acm3_human Human No 5.4 EC50 = 3981.1 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
414 6 0 6 2.9 CC1(CCC(CC1)OCCOC)N2CCC(CC2)N3C4=C(C=CC(=C4)C#N)OC3=O
CHEMBL2146599 acm3_human Human Yes 5.4 EC50 = 3981.1 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
315 2 1 3 2.7 CC1=CC2=C(C=C1)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL1223941 acm3_human Human No 5.4 EC50 = 3981.1 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
414 6 0 6 2.9 CC1(CCC(CC1)OCCOC)N2CCC(CC2)N3C4=C(C=CC(=C4)C#N)OC3=O
CHEMBL2146599 acm3_human Human Yes 5.4 EC50 = 3981.1 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
315 2 1 3 2.7 CC1=CC2=C(C=C1)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL69305 acm3_human Human No 6.3 EC50 = 500 Funct
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M3 determined by receptor selection and amplification technology (R-SAT)In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M3 determined by receptor selection and amplification technology (R-SAT)
182 2 1 4 0.7 CCOC1=NOC2=C1CNCCC2
CHEMBL2022960 acm3_human Human Yes 5.2 EC50 = 5900 Funct
Agonist activity at human muscarinic M3 receptor by calcium mobilization assayAgonist activity at human muscarinic M3 receptor by calcium mobilization assay
348 7 0 4 4.5 CCCCC1CCN(CC1)CCCN2C(=O)COC3=C2C=CC(=C3)F
CHEMBL2022960 acm3_human Human Yes 5.2 EC50 = 5900 Funct
Agonist activity at human muscarinic M3 receptor by calcium mobilization assayAgonist activity at human muscarinic M3 receptor by calcium mobilization assay
348 7 0 4 4.5 CCCCC1CCN(CC1)CCCN2C(=O)COC3=C2C=CC(=C3)F
CHEMBL304142 acm3_human Human Yes 6.2 EC50 = 620 Funct
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M3 determined by receptor selection and amplification technology (R-SAT)In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M3 determined by receptor selection and amplification technology (R-SAT)
168 1 1 4 0.3 COC1=NOC2=C1CNCCC2
CHEMBL1223803 acm3_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
385 5 0 3 4.2 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C(=O)CC4=C3C=C(C=C4)C
CHEMBL1223803 acm3_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
385 5 0 3 4.2 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C(=O)CC4=C3C=C(C=C4)C
CHEMBL1223940 acm3_human Human No 6.2 EC50 = 631.0 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
403 6 0 5 3.5 CC1=CC2=C(C=C1)OC(=O)N2C3CCN(CC3)C4(CCC(CC4)OCCOC)C
CHEMBL1223940 acm3_human Human No 6.2 EC50 = 631.0 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
403 6 0 5 3.5 CC1=CC2=C(C=C1)OC(=O)N2C3CCN(CC3)C4(CCC(CC4)OCCOC)C
CHEMBL523685 acm3_human Human Yes 5.2 EC50 = 6380 Funct
Activation of human muscarinic M3 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M3 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL523685 acm3_human Human Yes 5.2 EC50 = 6380 Funct
Activation of human muscarinic M3 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M3 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL523685 acm3_human Human Yes 5.2 EC50 = 6400 Funct
Agonist activity at human muscarinic M3 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M3 expressed in CHO cells assessed as stimulation of calcium mobilization
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL523685 acm3_human Human Yes 5.2 EC50 = 6400 Funct
Positive allosteric modulation activity at muscarinic M3 receptorPositive allosteric modulation activity at muscarinic M3 receptor
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL523685 acm3_human Human Yes 5.2 EC50 = 6400 Funct
Positive allosteric modulation of muscarinic M3 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M3 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL523685 acm3_human Human Yes 5.2 EC50 = 6400 Funct
Agonist activity at human muscarinic M3 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M3 expressed in CHO cells assessed as stimulation of calcium mobilization
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL523685 acm3_human Human Yes 5.2 EC50 = 6400 Funct
Positive allosteric modulation activity at muscarinic M3 receptorPositive allosteric modulation activity at muscarinic M3 receptor
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL523685 acm3_human Human Yes 5.2 EC50 = 6400 Funct
Positive allosteric modulation of muscarinic M3 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M3 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL1223754 acm3_human Human No 7.1 EC50 = 79.4 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
404 5 1 4 4.1 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=C(C(=C4)C)F)NC3=O
CHEMBL1223754 acm3_human Human No 7.1 EC50 = 79.4 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
404 5 1 4 4.1 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=C(C(=C4)C)F)NC3=O
CHEMBL1223860 acm3_human Human No 6.1 EC50 = 794.3 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
390 4 0 5 4.1 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=C(C(=C4)C)F)OC3=O
CHEMBL1223860 acm3_human Human No 6.1 EC50 = 794.3 Funct
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
390 4 0 5 4.1 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=C(C(=C4)C)F)OC3=O
CHEMBL315676 acm3_human Human No 5.1 EC50 = 8400 Funct
Effective concentration for MIPA (muscarinic-stimulated inositol phosphate accumulation) activity in SK-N-SH neuroblastoma cells expressing human muscarinic M3 receptorEffective concentration for MIPA (muscarinic-stimulated inositol phosphate accumulation) activity in SK-N-SH neuroblastoma cells expressing human muscarinic M3 receptor
164 2 0 3 0.7 C#CCON=C1CN2CCC1C2
CHEMBL354738 acm3_human Human No 5.1 EC50 = 8800 Funct
Effective concentration for MIPA (muscarinic-stimulated inositol phosphate accumulation) activity in SK-N-SH neuroblastoma cells expressing human muscarinic M3 receptorEffective concentration for MIPA (muscarinic-stimulated inositol phosphate accumulation) activity in SK-N-SH neuroblastoma cells expressing human muscarinic M3 receptor
178 2 0 3 1.2 CC#CCON=C1CN2CCC1C2
CHEMBL352908 acm3_human Human No 5.1 EC50 = 8900 Funct
Effective concentration for MIPA (muscarinic-stimulated inositol phosphate accumulation) activity in SK-N-SH neuroblastoma cells expressing human muscarinic M3 receptorEffective concentration for MIPA (muscarinic-stimulated inositol phosphate accumulation) activity in SK-N-SH neuroblastoma cells expressing human muscarinic M3 receptor
154 2 0 3 0.9 CCON=C1CN2CCC1C2
CHEMBL168545 acm3_human Human No 5.0 EC50 = 9600 Funct
Effective concentration for MIPA (muscarinic-stimulated inositol phosphate accumulation) activity in SK-N-SH neuroblastoma cells expressing human muscarinic M3 receptorEffective concentration for MIPA (muscarinic-stimulated inositol phosphate accumulation) activity in SK-N-SH neuroblastoma cells expressing human muscarinic M3 receptor
192 2 0 3 1.6 CCC#CCON=C1CN2CCC1C2
CHEMBL3087959 acm3_human Human No 10.5 IC50 = 0.0 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
330 5 0 2 4.9 CC(C1CCCC1)(C2=CC=CC=C2)C(=O)OC3CC[N+](CC3)(C)C
CHEMBL1924040 acm3_human Human No 10.3 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
478 10 0 4 5.6 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCCOC4=CC=CC=C4)N5CCCCC5
CHEMBL1921908 acm3_human Human No 10.3 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
488 8 0 4 6.2 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCC4=CC=C(S4)Cl)N5CCCCC5
CHEMBL3087235 acm3_human Human No 10.3 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
476 8 0 4 6.6 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CCCC5=NC6=CC=CC=C6O5
CHEMBL3087230 acm3_human Human No 10.3 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
454 8 0 4 5.8 C1CCCC(CC1)(C2=CC=CS2)C(=O)OC3C[N+]4(CCC3CC4)CCCC5=CC=NC=C5
CHEMBL1924040 acm3_human Human No 10.3 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
478 10 0 4 5.6 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCCOC4=CC=CC=C4)N5CCCCC5
CHEMBL1921908 acm3_human Human No 10.3 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
488 8 0 4 6.2 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCC4=CC=C(S4)Cl)N5CCCCC5
CHEMBL1921907 acm3_human Human No 10.2 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
527 8 0 3 6.2 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCC4=CC(=CC=C4)Br)N5CCCCC5
CHEMBL1921925 acm3_human Human No 10.2 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
518 9 0 4 6.9 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCCC4=CC5=CC=CC=C5S4)N6CCCCC6
CHEMBL1921935 acm3_human Human No 10.2 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
484 10 0 5 5.3 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CCCOC4=CC=CC=C4)N5CCCCC5
CHEMBL3088086 acm3_human Human No 10.2 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
451 9 0 3 6.4 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CCCOC5=CC=CC=C5
CHEMBL3088081 acm3_human Human No 10.2 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
441 7 0 3 6.4 CC1=CC=C(S1)CC[N+]23CCC(CC2)C(C3)OC(=O)C4(CCCCCC4)C5=CC=CC5
CHEMBL3087961 acm3_human Human No 10.2 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
327 4 0 3 4.8 C1CCCC(CC1)(C2=CC=CC=C2)C(=O)OC3CN4CCC3CC4
CHEMBL1921907 acm3_human Human No 10.2 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
527 8 0 3 6.2 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCC4=CC(=CC=C4)Br)N5CCCCC5
CHEMBL1921925 acm3_human Human No 10.2 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
518 9 0 4 6.9 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCCC4=CC5=CC=CC=C5S4)N6CCCCC6
CHEMBL1921935 acm3_human Human No 10.2 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
484 10 0 5 5.3 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CCCOC4=CC=CC=C4)N5CCCCC5
CHEMBL1921937 acm3_human Human No 10.1 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
502 10 0 6 5.4 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CCCOC4=CC=C(C=C4)F)N5CCCCC5
CHEMBL1921917 acm3_human Human No 10.1 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
463 9 0 4 4.8 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCCC4=CC=NC=C4)N5CCCCC5
CHEMBL3088080 acm3_human Human No 10.1 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
421 7 0 2 6.3 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CCC5=CC=CC=C5
CHEMBL3087957 acm3_human Human No 10.1 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
474 7 0 4 6.0 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC5=NOC(=C5)C6=CC=CC=C6
CHEMBL3088075 acm3_human Human No 10.1 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
333 4 0 4 4.6 C1CCCC(CC1)(C2=CC=CS2)C(=O)OC3CN4CCC3CC4
CHEMBL1921937 acm3_human Human No 10.1 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
502 10 0 6 5.4 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CCCOC4=CC=C(C=C4)F)N5CCCCC5
CHEMBL1921917 acm3_human Human No 10.1 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
463 9 0 4 4.8 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCCC4=CC=NC=C4)N5CCCCC5
CHEMBL1924036 acm3_human Human No 10.0 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
352 5 0 4 3.2 CC(C1=CC=CS1)(C(=O)OC2CC[N+](CC2)(C)C)N3CCCCC3
CHEMBL1921945 acm3_human Human No 10.0 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
501 8 1 6 4.3 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=CC(=CC=C4)F)N5CCCCC5
CHEMBL1922053 acm3_human Human No 10.0 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
519 8 1 7 3.3 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=CN=CC(=N4)Cl)N5CCCCC5
CHEMBL1924036 acm3_human Human No 10.0 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
352 5 0 4 3.2 CC(C1=CC=CS1)(C(=O)OC2CC[N+](CC2)(C)C)N3CCCCC3
CHEMBL1921945 acm3_human Human No 10.0 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
501 8 1 6 4.3 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=CC(=CC=C4)F)N5CCCCC5
CHEMBL1922053 acm3_human Human No 10.0 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
519 8 1 7 3.3 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=CN=CC(=N4)Cl)N5CCCCC5
CHEMBL3087952 acm3_human Human No 10.0 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
448 6 0 4 5.7 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC5=NC6=CC=CC=C6O5
CHEMBL3087949 acm3_human Human No 10.0 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
486 7 1 5 4.4 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)NC5=CN=CC(=N5)Cl
CHEMBL3087242 acm3_human Human No 10.0 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
440 7 2 4 3.9 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)NC5=CC=NN5
CHEMBL1921941 acm3_human Human No 9.9 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
407 7 1 5 2.2 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)N)N4CCCCC4
CHEMBL1921919 acm3_human Human No 9.9 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
477 9 0 4 5.2 CC1=NC=CC(=C1)CCC[N+]23CCC(CC2)C(C3)OC(=O)C(C)(C4=CC=CC=C4)N5CCCCC5
CHEMBL1921946 acm3_human Human No 9.9 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
478 8 1 5 3.7 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=CC=CC=N4)N5CCCCC5
CHEMBL1924049 acm3_human Human No 9.9 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
466 8 0 4 5.6 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCC4=CC=CC=C4F)N5CCCCC5
CHEMBL1921941 acm3_human Human No 9.9 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
407 7 1 5 2.2 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)N)N4CCCCC4
CHEMBL1921919 acm3_human Human No 9.9 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
477 9 0 4 5.2 CC1=NC=CC(=C1)CCC[N+]23CCC(CC2)C(C3)OC(=O)C(C)(C4=CC=CC=C4)N5CCCCC5
CHEMBL1921946 acm3_human Human No 9.9 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
478 8 1 5 3.7 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=CC=CC=N4)N5CCCCC5
CHEMBL1924049 acm3_human Human No 9.9 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
466 8 0 4 5.6 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCC4=CC=CC=C4F)N5CCCCC5
CHEMBL1201335 acm3_human Human Yes 9.9 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
318 5 1 3 3.1 C[N+]1(CCC(C1)OC(=O)C(C2CCCC2)(C3=CC=CC=C3)O)C
CHEMBL3088085 acm3_human Human No 9.9 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
451 9 0 3 5.7 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CCOCC5=CC=CC=C5
CHEMBL3087238 acm3_human Human No 9.9 IC50 = 0.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
468 7 1 4 5.4 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)NC5=CC(=CC=C5)F
CHEMBL1921918 acm3_human Human No 9.8 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
469 9 0 5 4.5 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CCCC4=CC=NC=C4)N5CCCCC5
CHEMBL1924025 acm3_human Human No 9.8 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
472 8 0 5 5.3 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CCC4=CC=CC=C4F)N5CCCCC5
CHEMBL1922051 acm3_human Human No 9.8 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
468 8 1 6 3.2 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=NOC=C4)N5CCCCC5
CHEMBL1921904 acm3_human Human Yes 9.8 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
466 8 0 4 5.6 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCC4=CC=C(C=C4)F)N5CCCCC5
CHEMBL1921911 acm3_human Human No 9.8 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
492 8 0 4 4.7 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCC4=CC5CCOC5C=C4)N6CCCCC6
CHEMBL1922054 acm3_human Human No 9.8 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
489 7 0 5 5.3 CC1=CC2=C(C=C1)N=C(O2)C[N+]34CCC(CC3)C(C4)OC(=O)C(C)(C5=CC=CC=C5)N6CCCCC6
CHEMBL3087953 acm3_human Human No 9.8 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
475 7 0 5 5.8 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC5=NC(=NO5)C6=CC=CC=C6
CHEMBL3087241 acm3_human Human No 9.8 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
455 7 1 5 4.4 CC1=CC(=NO1)NC(=O)C[N+]23CCC(CC2)C(C3)OC(=O)C4(CCCCCC4)C5=CC=CC5
CHEMBL3087368 acm3_human Human No 9.8 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
452 7 1 5 3.5 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)NC5=NN=CC=C5
CHEMBL3087362 acm3_human Human No 9.8 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
451 7 1 4 4.5 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)NC5=CC=CC=N5
CHEMBL3088084 acm3_human Human No 9.8 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
437 8 0 3 6.0 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CCOC5=CC=CC=C5
CHEMBL3087367 acm3_human Human No 9.8 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
452 7 1 5 3.9 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)NC5=NC=NC=C5
CHEMBL3087232 acm3_human Human No 9.8 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
450 8 0 3 6.0 CC1=NC=C(C=C1)CCC[N+]23CCC(CC2)C(C3)OC(=O)C4(CCCCCC4)C5=CC=CC5
CHEMBL1921918 acm3_human Human No 9.8 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
469 9 0 5 4.5 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CCCC4=CC=NC=C4)N5CCCCC5
CHEMBL1924025 acm3_human Human No 9.8 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
472 8 0 5 5.3 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CCC4=CC=CC=C4F)N5CCCCC5
CHEMBL1922051 acm3_human Human No 9.8 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
468 8 1 6 3.2 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=NOC=C4)N5CCCCC5
CHEMBL1921904 acm3_human Human Yes 9.8 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
466 8 0 4 5.6 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCC4=CC=C(C=C4)F)N5CCCCC5
CHEMBL1921911 acm3_human Human No 9.8 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
492 8 0 4 4.7 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCC4=CC5CCOC5C=C4)N6CCCCC6
CHEMBL1922054 acm3_human Human No 9.8 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
489 7 0 5 5.3 CC1=CC2=C(C=C1)N=C(O2)C[N+]34CCC(CC3)C(C4)OC(=O)C(C)(C5=CC=CC=C5)N6CCCCC6
CHEMBL1921943 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
483 8 1 5 4.2 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=CC=CC=C4)N5CCCCC5
CHEMBL1921927 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
476 10 0 3 6.2 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCCCC4=CC=CC=C4)N5CCCCC5
CHEMBL1921942 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
477 8 1 4 4.5 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=CC=CC=C4)N5CCCCC5
CHEMBL1922052 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
474 8 1 7 3.0 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=NOC=C4)N5CCCCC5
CHEMBL1921910 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
498 8 0 3 6.8 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCC4=CC5=CC=CC=C5C=C4)N6CCCCC6
CHEMBL1922055 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
501 8 0 5 5.2 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CC4=NOC(=C4)C5=CC=CC=C5)N6CCCCC6
CHEMBL1922050 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
479 8 1 6 2.7 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=NC=CN=C4)N5CCCCC5
CHEMBL1921940 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
401 7 1 4 2.5 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)N)N4CCCCC4
CHEMBL1921944 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
495 8 1 5 4.6 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=CC(=CC=C4)F)N5CCCCC5
CHEMBL1921914 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
460 8 0 4 6.4 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CCC4CCCCC4)N5CCCCC5
CHEMBL1921943 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
483 8 1 5 4.2 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=CC=CC=C4)N5CCCCC5
CHEMBL1921927 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
476 10 0 3 6.2 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCCCC4=CC=CC=C4)N5CCCCC5
CHEMBL1921942 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
477 8 1 4 4.5 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=CC=CC=C4)N5CCCCC5
CHEMBL1922052 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
474 8 1 7 3.0 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=NOC=C4)N5CCCCC5
CHEMBL1921910 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
498 8 0 3 6.8 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCC4=CC5=CC=CC=C5C=C4)N6CCCCC6
CHEMBL1922055 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
501 8 0 5 5.2 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CC4=NOC(=C4)C5=CC=CC=C5)N6CCCCC6
CHEMBL1922050 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
479 8 1 6 2.7 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=NC=CN=C4)N5CCCCC5
CHEMBL1921940 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
401 7 1 4 2.5 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)N)N4CCCCC4
CHEMBL1921944 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
495 8 1 5 4.6 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=CC(=CC=C4)F)N5CCCCC5
CHEMBL1921914 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
460 8 0 4 6.4 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CCC4CCCCC4)N5CCCCC5
CHEMBL3087236 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
374 6 1 3 3.3 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)N
CHEMBL3087364 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
451 7 1 4 4.2 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)NC5=CN=CC=C5
CHEMBL3087946 acm3_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
486 7 1 5 4.5 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)NC5=NN=C(C=C5)Cl
CHEMBL551729 acm3_human Human No 9.6 IC50 = 0.2 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation counting
349 5 1 6 2.7 C1CN2CCC1C(C2)OC(=O)C(C3=CC=CS3)(C4=CC=CS4)O
CHEMBL3670825 acm3_human Human No 9.6 IC50 = 0.2 Funct
BindingDB_Patents: Radioligand Binding Assay. Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). Incubations of test ligands (or standard) with 0.2 nM [3H]4-DAMP were incubated for 120 minutes at 22 C. using human M3 receptor-expressing cell homogenates. Specific ligand binding to the receptors was defined as the difference between the total radioligand binding and the nonspecific binding determined in the presence of an excess of unlabelled ligand (10 atropine). The results were expressed as a percent of control specific binding ((measured specific binding/control specific binding)x100) obtained in the presence of various concentrations of the test compounds.BindingDB_Patents: Radioligand Binding Assay. Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). Incubations of test ligands (or standard) with 0.2 nM [3H]4-DAMP were incubated for 120 minutes at 22 C. using human M3 receptor-expressing cell homogenates. Specific ligand binding to the receptors was defined as the difference between the total radioligand binding and the nonspecific binding determined in the presence of an excess of unlabelled ligand (10 atropine). The results were expressed as a percent of control specific binding ((measured specific binding/control specific binding)x100) obtained in the presence of various concentrations of the test compounds.
343 5 0 2 5.2 CC(C1CCCC1)(C2=CC=CC=C2)C(=O)OC3CC4CCC3[N+]4(C)C
CHEMBL551729 acm3_human Human No 9.6 IC50 = 0.2 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation counting
349 5 1 6 2.7 C1CN2CCC1C(C2)OC(=O)C(C3=CC=CS3)(C4=CC=CS4)O
CHEMBL3670827 acm3_human Human No 9.6 IC50 = 0.3 Funct
Radioligand Binding Assay: Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). Incubations of test ligands (or standard) with 0.2 nM [3H]4-DAMP were incubated for 120 minutes at 22 C. using human M3 receptor-expressing cell homogenates. Specific ligand binding to the receptors was defined as the difference between the total radioligand binding and the nonspecific binding determined in the presence of an excess of unlabelled ligand (10 atropine). The results were expressed as a percent of control specific binding ((measured specific binding/control specific binding)x100) obtained in the presence of various concentrations of the test compounds.Radioligand Binding Assay: Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). Incubations of test ligands (or standard) with 0.2 nM [3H]4-DAMP were incubated for 120 minutes at 22 C. using human M3 receptor-expressing cell homogenates. Specific ligand binding to the receptors was defined as the difference between the total radioligand binding and the nonspecific binding determined in the presence of an excess of unlabelled ligand (10 atropine). The results were expressed as a percent of control specific binding ((measured specific binding/control specific binding)x100) obtained in the presence of various concentrations of the test compounds.
344 5 1 3 3.7 C[N+]1(C2CCC1C(C2)OC(=O)C(C3CCCC3)(C4=CC=CC=C4)O)C
CHEMBL3670826 acm3_human Human No 9.6 IC50 = 0.3 Funct
Radioligand Binding Assay: Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). Incubations of test ligands (or standard) with 0.2 nM [3H]4-DAMP were incubated for 120 minutes at 22 C. using human M3 receptor-expressing cell homogenates. Specific ligand binding to the receptors was defined as the difference between the total radioligand binding and the nonspecific binding determined in the presence of an excess of unlabelled ligand (10 atropine). The results were expressed as a percent of control specific binding ((measured specific binding/control specific binding)x100) obtained in the presence of various concentrations of the test compounds.Radioligand Binding Assay: Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). Incubations of test ligands (or standard) with 0.2 nM [3H]4-DAMP were incubated for 120 minutes at 22 C. using human M3 receptor-expressing cell homogenates. Specific ligand binding to the receptors was defined as the difference between the total radioligand binding and the nonspecific binding determined in the presence of an excess of unlabelled ligand (10 atropine). The results were expressed as a percent of control specific binding ((measured specific binding/control specific binding)x100) obtained in the presence of various concentrations of the test compounds.
344 5 1 3 3.7 C[N+]1(C2CCC1C(C2)OC(=O)C(C3CCCC3)(C4=CC=CC=C4)O)C
CHEMBL1922058 acm3_human Human No 9.6 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
508 8 0 7 4.7 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CC4=NOC(=N4)C5=CC=CC=C5)N6CCCCC6
CHEMBL1201335 acm3_human Human Yes 9.6 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
318 5 1 3 3.1 C[N+]1(CCC(C1)OC(=O)C(C2CCCC2)(C3=CC=CC=C3)O)C
CHEMBL1921928 acm3_human Human No 9.6 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
482 10 0 4 5.9 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CCCCC4=CC=CC=C4)N5CCCCC5
CHEMBL1924029 acm3_human Human No 9.6 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
346 5 0 3 3.5 CC(C1=CC=CC=C1)(C(=O)OC2CC[N+](CC2)(C)C)N3CCCCC3
CHEMBL3087237 acm3_human Human No 9.6 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
450 7 1 3 5.3 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)NC5=CC=CC=C5
CHEMBL3087375 acm3_human Human No 9.6 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
519 7 1 7 5.1 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)NC5=CN=C(C=C5)C(F)(F)F
CHEMBL3087960 acm3_human Human No 9.6 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
330 4 0 2 4.8 C[N+]1(CCC(CC1)OC(=O)C2(CCCCCC2)C3=CC=CC=C3)C
CHEMBL3087954 acm3_human Human No 9.6 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
474 7 0 4 6.0 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC5=CC(=NO5)C6=CC=CC=C6
CHEMBL3087370 acm3_human Human No 9.6 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
469 7 1 5 4.6 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)NC5=C(C=CC=N5)F
CHEMBL1922058 acm3_human Human No 9.6 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
508 8 0 7 4.7 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CC4=NOC(=N4)C5=CC=CC=C5)N6CCCCC6
CHEMBL1201335 acm3_human Human Yes 9.6 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
318 5 1 3 3.1 C[N+]1(CCC(C1)OC(=O)C(C2CCCC2)(C3=CC=CC=C3)O)C
CHEMBL1921928 acm3_human Human No 9.6 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
482 10 0 4 5.9 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CCCCC4=CC=CC=C4)N5CCCCC5
CHEMBL1924029 acm3_human Human No 9.6 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
346 5 0 3 3.5 CC(C1=CC=CC=C1)(C(=O)OC2CC[N+](CC2)(C)C)N3CCCCC3
CHEMBL3670828 acm3_human Human No 9.5 IC50 = 0.3 Funct
Radioligand Binding Assay: Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). Incubations of test ligands (or standard) with 0.2 nM [3H]4-DAMP were incubated for 120 minutes at 22 C. using human M3 receptor-expressing cell homogenates. Specific ligand binding to the receptors was defined as the difference between the total radioligand binding and the nonspecific binding determined in the presence of an excess of unlabelled ligand (10 atropine). The results were expressed as a percent of control specific binding ((measured specific binding/control specific binding)x100) obtained in the presence of various concentrations of the test compounds.Radioligand Binding Assay: Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). Incubations of test ligands (or standard) with 0.2 nM [3H]4-DAMP were incubated for 120 minutes at 22 C. using human M3 receptor-expressing cell homogenates. Specific ligand binding to the receptors was defined as the difference between the total radioligand binding and the nonspecific binding determined in the presence of an excess of unlabelled ligand (10 atropine). The results were expressed as a percent of control specific binding ((measured specific binding/control specific binding)x100) obtained in the presence of various concentrations of the test compounds.
344 5 1 3 3.7 C[N+]1(C2CCC1C(C2)OC(=O)C(C3CCCC3)(C4=CC=CC=C4)O)C
CHEMBL564747 acm3_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation counting
343 5 1 5 3.0 C1CN2CCC1C(C2)OC(=O)C(C3=CC=CC=C3)(C4=CC=CS4)O
CHEMBL564747 acm3_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation counting
343 5 1 5 3.0 C1CN2CCC1C(C2)OC(=O)C(C3=CC=CC=C3)(C4=CC=CS4)O
CHEMBL1921924 acm3_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
503 9 0 5 5.7 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCCC4=NC5=CC=CC=C5O4)N6CCCCC6
CHEMBL1921921 acm3_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
463 9 0 4 4.8 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCCC4=CN=CC=C4)N5CCCCC5
CHEMBL1922056 acm3_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
502 8 0 6 5.0 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CC4=NC(=NO4)C5=CC=CC=C5)N6CCCCC6
CHEMBL1921932 acm3_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
478 9 0 4 5.6 CC1=CC=C(C=C1)OCC[N+]23CCC(CC2)C(C3)OC(=O)C(C)(C4=CC=CC=C4)N5CCCCC5
CHEMBL3087958 acm3_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
475 7 0 5 5.4 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC5=NN=C(O5)C6=CC=CC=C6
CHEMBL1921924 acm3_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
503 9 0 5 5.7 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCCC4=NC5=CC=CC=C5O4)N6CCCCC6
CHEMBL1921921 acm3_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
463 9 0 4 4.8 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCCC4=CN=CC=C4)N5CCCCC5
CHEMBL1922056 acm3_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
502 8 0 6 5.0 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CC4=NC(=NO4)C5=CC=CC=C5)N6CCCCC6
CHEMBL1921932 acm3_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
478 9 0 4 5.6 CC1=CC=C(C=C1)OCC[N+]23CCC(CC2)C(C3)OC(=O)C(C)(C4=CC=CC=C4)N5CCCCC5
CHEMBL562642 acm3_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation counting
335 5 1 5 3.1 C1CCC(C1)C(C2=CC=CS2)(C(=O)OC3CN4CCC3CC4)O
CHEMBL562642 acm3_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation counting
335 5 1 5 3.1 C1CCC(C1)C(C2=CC=CS2)(C(=O)OC3CN4CCC3CC4)O
CHEMBL1922057 acm3_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
507 8 0 6 4.9 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CC4=CC(=NO4)C5=CC=CC=C5)N6CCCCC6
CHEMBL1921926 acm3_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
519 9 0 5 6.3 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCCC4=CC5=C(C=C4)N=CS5)N6CCCCC6
CHEMBL3087955 acm3_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
473 7 0 3 5.9 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC5=NN(C=C5)C6=CC=CC=C6
CHEMBL3087377 acm3_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
466 7 1 5 4.3 CC1=NC=CC(=N1)NC(=O)C[N+]23CCC(CC2)C(C3)OC(=O)C4(CCCCCC4)C5=CC=CC5
CHEMBL3087244 acm3_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
458 7 1 6 4.4 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)NC5=NC=NS5
CHEMBL1922057 acm3_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
507 8 0 6 4.9 CC(C1=CC=CS1)(C(=O)OC2C[N+]3(CCC2CC3)CC4=CC(=NO4)C5=CC=CC=C5)N6CCCCC6
CHEMBL1921926 acm3_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
519 9 0 5 6.3 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCCC4=CC5=C(C=C4)N=CS5)N6CCCCC6
CHEMBL556426 acm3_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation counting
343 5 1 5 3.0 C1CN2CCC1C(C2)OC(=O)C(C3=CC=CC=C3)(C4=CC=CS4)O
CHEMBL556426 acm3_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation counting
343 5 1 5 3.0 C1CN2CCC1C(C2)OC(=O)C(C3=CC=CC=C3)(C4=CC=CS4)O
CHEMBL1921939 acm3_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
492 11 0 4 5.4 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCOCCC4=CC=CC=C4)N5CCCCC5
CHEMBL3087371 acm3_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
465 7 1 4 4.9 CC1=CN=C(C=C1)NC(=O)C[N+]23CCC(CC2)C(C3)OC(=O)C4(CCCCCC4)C5=CC=CC5
CHEMBL3087234 acm3_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
439 8 0 3 5.0 CN1C=CC(=N1)CCC[N+]23CCC(CC2)C(C3)OC(=O)C4(CCCCCC4)C5=CC=CC5
CHEMBL1921939 acm3_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
492 11 0 4 5.4 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCOCCC4=CC=CC=C4)N5CCCCC5
CHEMBL1779033 acm3_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
342 5 0 4 3.5 C1CN2CCC1C(C2)OC(=O)N(CC3=CC=CS3)C4=CC=CC=C4
CHEMBL1779033 acm3_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
342 5 0 4 3.5 C1CN2CCC1C(C2)OC(=O)N(CC3=CC=CS3)C4=CC=CC=C4
CHEMBL1921929 acm3_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
464 9 0 4 5.2 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCOC4=CC=CC=C4)N5CCCCC5
CHEMBL1924046 acm3_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
426 8 0 3 5.5 CC(=CCC[N+]12CCC(CC1)C(C2)OC(=O)C(C)(C3=CC=CC=C3)N4CCCCC4)C
CHEMBL1921936 acm3_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
496 10 0 5 5.7 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCCOC4=CC=C(C=C4)F)N5CCCCC5
CHEMBL1921929 acm3_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
464 9 0 4 5.2 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCOC4=CC=CC=C4)N5CCCCC5
CHEMBL1924046 acm3_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
426 8 0 3 5.5 CC(=CCC[N+]12CCC(CC1)C(C2)OC(=O)C(C)(C3=CC=CC=C3)N4CCCCC4)C
CHEMBL1921936 acm3_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
496 10 0 5 5.7 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCCOC4=CC=C(C=C4)F)N5CCCCC5
CHEMBL3087372 acm3_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
469 7 1 5 4.6 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)NC5=NC=C(C=C5)F
CHEMBL3087366 acm3_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
452 7 1 5 3.5 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)NC5=CN=CN=C5
CHEMBL3087948 acm3_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
466 7 1 5 3.9 CC1=CN=CC(=N1)NC(=O)C[N+]23CCC(CC2)C(C3)OC(=O)C4(CCCCCC4)C5=CC=CC5
CHEMBL554699 acm3_human Human No 9.2 IC50 = 0.7 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation counting
335 5 1 5 3.1 C1CCC(C1)C(C2=CC=CS2)(C(=O)OC3CN4CCC3CC4)O
CHEMBL554699 acm3_human Human No 9.2 IC50 = 0.7 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation counting
335 5 1 5 3.1 C1CCC(C1)C(C2=CC=CS2)(C(=O)OC3CN4CCC3CC4)O
CHEMBL549577 acm3_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation counting
335 3 0 4 3.2 C1CN2CCC1C(C2)OC(=O)C3C4=CC=CC=C4OC5=CC=CC=C35
CHEMBL549577 acm3_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation counting
335 3 0 4 3.2 C1CN2CCC1C(C2)OC(=O)C3C4=CC=CC=C4OC5=CC=CC=C35
CHEMBL1921938 acm3_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
478 10 0 4 4.9 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCOCC4=CC=CC=C4)N5CCCCC5
CHEMBL1924031 acm3_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
364 5 0 4 3.1 CC(C1=CC=CC=C1)(C(=O)OC2CC[N+](CC2)(C)C)N3CCSCC3
CHEMBL1924030 acm3_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
353 5 0 3 4.3 CC(C1=CC=CC=C1)(C(=O)OC2CC[N+](CC2)(C)C)N3C=CC=CC=C3
CHEMBL3087379 acm3_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
466 7 1 5 3.9 CC1=NN=C(C=C1)NC(=O)C[N+]23CCC(CC2)C(C3)OC(=O)C4(CCCCCC4)C5=CC=CC5
CHEMBL3087376 acm3_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
465 7 1 4 4.6 CC1=NC=C(C=C1)NC(=O)C[N+]23CCC(CC2)C(C3)OC(=O)C4(CCCCCC4)C5=CC=CC5
CHEMBL3087947 acm3_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
466 7 1 5 3.9 CC1=CN=C(C=N1)NC(=O)C[N+]23CCC(CC2)C(C3)OC(=O)C4(CCCCCC4)C5=CC=CC5
CHEMBL3087373 acm3_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
465 7 1 4 4.9 CC1=CC(=NC=C1)NC(=O)C[N+]23CCC(CC2)C(C3)OC(=O)C4(CCCCCC4)C5=CC=CC5
CHEMBL1921938 acm3_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
478 10 0 4 4.9 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCOCC4=CC=CC=C4)N5CCCCC5
CHEMBL1924031 acm3_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
364 5 0 4 3.1 CC(C1=CC=CC=C1)(C(=O)OC2CC[N+](CC2)(C)C)N3CCSCC3
CHEMBL1924030 acm3_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
353 5 0 3 4.3 CC(C1=CC=CC=C1)(C(=O)OC2CC[N+](CC2)(C)C)N3C=CC=CC=C3
CHEMBL563887 acm3_human Human No 9.0 IC50 = 0.9 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation counting
335 3 1 4 3.0 C1CN2CCC1C(C2)OC(=O)C3(C4=CC=CC=C4C5=CC=CC=C53)O
CHEMBL563887 acm3_human Human No 9.0 IC50 = 0.9 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation counting
335 3 1 4 3.0 C1CN2CCC1C(C2)OC(=O)C3(C4=CC=CC=C4C5=CC=CC=C53)O
CHEMBL1779034 acm3_human Human No 9.0 IC50 = 1 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
342 5 0 4 3.5 C1CN2CCC1C(C2)OC(=O)N(CC3=CSC=C3)C4=CC=CC=C4
CHEMBL1921933 acm3_human Human No 9.0 IC50 = 1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
478 9 0 4 5.6 CC1=CC(=CC=C1)OCC[N+]23CCC(CC2)C(C3)OC(=O)C(C)(C4=CC=CC=C4)N5CCCCC5
CHEMBL1922049 acm3_human Human No 9.0 IC50 = 1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
479 8 1 6 2.7 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=NN=CC=C4)N5CCCCC5
CHEMBL1924033 acm3_human Human No 9.0 IC50 = 1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
360 5 0 3 4.0 CC1CCN(CC1)C(C)(C2=CC=CC=C2)C(=O)OC3CC[N+](CC3)(C)C
CHEMBL1924042 acm3_human Human No 9.0 IC50 = 1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
386 6 0 3 4.4 CC(C)[N+]12CCC(CC1)C(C2)OC(=O)C(C)(C3=CC=CC=C3)N4CCCCC4
CHEMBL1779034 acm3_human Human No 9.0 IC50 = 1 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
342 5 0 4 3.5 C1CN2CCC1C(C2)OC(=O)N(CC3=CSC=C3)C4=CC=CC=C4
CHEMBL1921933 acm3_human Human No 9.0 IC50 = 1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
478 9 0 4 5.6 CC1=CC(=CC=C1)OCC[N+]23CCC(CC2)C(C3)OC(=O)C(C)(C4=CC=CC=C4)N5CCCCC5
CHEMBL1922049 acm3_human Human No 9.0 IC50 = 1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
479 8 1 6 2.7 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=NN=CC=C4)N5CCCCC5
CHEMBL1924033 acm3_human Human No 9.0 IC50 = 1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
360 5 0 3 4.0 CC1CCN(CC1)C(C)(C2=CC=CC=C2)C(=O)OC3CC[N+](CC3)(C)C
CHEMBL1924042 acm3_human Human No 9.0 IC50 = 1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
386 6 0 3 4.4 CC(C)[N+]12CCC(CC1)C(C2)OC(=O)C(C)(C3=CC=CC=C3)N4CCCCC4
CHEMBL3087378 acm3_human Human No 9.0 IC50 = 1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
466 7 1 5 4.3 CC1=CC(=NC=N1)NC(=O)C[N+]23CCC(CC2)C(C3)OC(=O)C4(CCCCCC4)C5=CC=CC5
CHEMBL3087233 acm3_human Human No 9.0 IC50 = 1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
464 8 0 3 6.4 CC1=NC(=C(C=C1)CCC[N+]23CCC(CC2)C(C3)OC(=O)C4(CCCCCC4)C5=CC=CC5)C
CHEMBL3401643 acm3_human Human No 9.0 IC50 = 1.1 Funct
Displacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
334 4 2 4 2.6 C1CCC(C1)C(C2=CC=CS2)(C(=O)NC3CN4CCC3CC4)O
CHEMBL3401643 acm3_human Human No 9.0 IC50 = 1.1 Funct
Displacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
334 4 2 4 2.6 C1CCC(C1)C(C2=CC=CS2)(C(=O)NC3CN4CCC3CC4)O
CHEMBL1777826 acm3_human Human No 8.9 IC50 = 1.2 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
336 5 0 3 3.8 C1CN2CCC1C(C2)OC(=O)N(CC3=CC=CC=C3)C4=CC=CC=C4
CHEMBL1777826 acm3_human Human No 8.9 IC50 = 1.2 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
336 5 0 3 3.8 C1CN2CCC1C(C2)OC(=O)N(CC3=CC=CC=C3)C4=CC=CC=C4
CHEMBL1289653 acm3_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
406 3 0 5 3.3 CC1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC(=CC=C4)Cl
CHEMBL1289653 acm3_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
406 3 0 5 3.3 CC1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC(=CC=C4)Cl
CHEMBL1922048 acm3_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
479 8 1 6 3.1 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=NC=NC=C4)N5CCCCC5
CHEMBL1921931 acm3_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
498 9 0 4 5.8 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCOC4=CC=C(C=C4)Cl)N5CCCCC5
CHEMBL1924032 acm3_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
381 5 0 5 3.8 CC(C1=CC=CC=C1)(C(=O)OC2CC[N+](CC2)(C)C)N3CCC(CC3)(F)F
CHEMBL1921922 acm3_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
477 9 0 4 5.2 CC1=NC=C(C=C1)CCC[N+]23CCC(CC2)C(C3)OC(=O)C(C)(C4=CC=CC=C4)N5CCCCC5
CHEMBL1922048 acm3_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
479 8 1 6 3.1 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CC(=O)NC4=NC=NC=C4)N5CCCCC5
CHEMBL1921931 acm3_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
498 9 0 4 5.8 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCOC4=CC=C(C=C4)Cl)N5CCCCC5
CHEMBL1924032 acm3_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
381 5 0 5 3.8 CC(C1=CC=CC=C1)(C(=O)OC2CC[N+](CC2)(C)C)N3CCC(CC3)(F)F
CHEMBL1921922 acm3_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
477 9 0 4 5.2 CC1=NC=C(C=C1)CCC[N+]23CCC(CC2)C(C3)OC(=O)C(C)(C4=CC=CC=C4)N5CCCCC5
CHEMBL1779045 acm3_human Human No 8.9 IC50 = 1.4 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
404 5 0 6 4.5 CC1=CC(=CC=C1)N(CC2=CC(=C(C=C2F)F)F)C(=O)OC3CN4CCC3CC4
CHEMBL1779045 acm3_human Human No 8.9 IC50 = 1.4 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
404 5 0 6 4.5 CC1=CC(=CC=C1)N(CC2=CC(=C(C=C2F)F)F)C(=O)OC3CN4CCC3CC4
CHEMBL1779046 acm3_human Human Yes 8.8 IC50 = 1.5 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
408 5 0 7 4.2 C1CN2CCC1C(C2)OC(=O)N(CC3=CC(=C(C(=C3)F)F)F)C4=CC(=CC=C4)F
CHEMBL1779046 acm3_human Human Yes 8.8 IC50 = 1.5 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
408 5 0 7 4.2 C1CN2CCC1C(C2)OC(=O)N(CC3=CC(=C(C(=C3)F)F)F)C4=CC(=CC=C4)F
CHEMBL1921913 acm3_human Human No 8.8 IC50 = 1.6 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
487 8 1 3 5.6 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCC4=CNC5=CC=CC=C54)N6CCCCC6
CHEMBL1921913 acm3_human Human No 8.8 IC50 = 1.6 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
487 8 1 3 5.6 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCC4=CNC5=CC=CC=C54)N6CCCCC6
CHEMBL1779037 acm3_human Human No 8.8 IC50 = 1.7 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
316 7 0 3 4.1 CCCCCN(C1=CC=CC=C1)C(=O)OC2CN3CCC2CC3
CHEMBL1779037 acm3_human Human No 8.8 IC50 = 1.7 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
316 7 0 3 4.1 CCCCCN(C1=CC=CC=C1)C(=O)OC2CN3CCC2CC3
CHEMBL1084850 acm3_human Human No 8.7 IC50 = 2.0 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
330 5 2 2 4.4 C1CNCCC1CCC(C2=CC=CC=C2C3=CC(=CC=C3)Cl)O
CHEMBL1084850 acm3_human Human No 8.7 IC50 = 2.0 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
330 5 2 2 4.4 C1CNCCC1CCC(C2=CC=CC=C2C3=CC(=CC=C3)Cl)O
CHEMBL492978 acm3_human Human No 8.0 IC50 = 10 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
430 8 2 4 3.8 CCOC1=CC=CC(=C1)C(=O)NCC2=CC=CC(=C2)C3=CC(=CC=C3)CN4CCNCC4
CHEMBL493328 acm3_human Human No 8.0 IC50 = 10 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
444 6 2 5 3.7 CC1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL522020 acm3_human Human No 8.0 IC50 = 10 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
428 7 2 4 3.2 CC(=O)C1=CC(=CC=C1)C(=O)NCC2=CC=CC(=C2)C3=CC(=CC=C3)CN4CCNCC4
CHEMBL486982 acm3_human Human No 8.0 IC50 = 10 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
561 12 5 7 4.0 CCCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL1289545 acm3_human Human No 8.0 IC50 = 10 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
406 3 0 5 3.3 CC1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=C(C=C4)Cl
CHEMBL1924034 acm3_human Human No 8.0 IC50 = 10 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
305 5 0 3 2.7 CC(C1=CC=CC=C1)(C(=O)OC2CC[N+](CC2)(C)C)N(C)C
CHEMBL492978 acm3_human Human No 8.0 IC50 = 10 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
430 8 2 4 3.8 CCOC1=CC=CC(=C1)C(=O)NCC2=CC=CC(=C2)C3=CC(=CC=C3)CN4CCNCC4
CHEMBL493328 acm3_human Human No 8.0 IC50 = 10 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
444 6 2 5 3.7 CC1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL522020 acm3_human Human No 8.0 IC50 = 10 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
428 7 2 4 3.2 CC(=O)C1=CC(=CC=C1)C(=O)NCC2=CC=CC(=C2)C3=CC(=CC=C3)CN4CCNCC4
CHEMBL486982 acm3_human Human No 8.0 IC50 = 10 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
561 12 5 7 4.0 CCCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL1289545 acm3_human Human No 8.0 IC50 = 10 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
406 3 0 5 3.3 CC1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=C(C=C4)Cl
CHEMBL1924034 acm3_human Human No 8.0 IC50 = 10 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
305 5 0 3 2.7 CC(C1=CC=CC=C1)(C(=O)OC2CC[N+](CC2)(C)C)N(C)C
CHEMBL3087361 acm3_human Human No 8.0 IC50 = 10 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
497 8 1 5 5.8 CC(C)(C)C1=CC(=NO1)NC(=O)C[N+]23CCC(CC2)C(C3)OC(=O)C4(CCCCCC4)C5=CC=CC5
CHEMBL2206587 acm3_human Human No 8.0 IC50 = 10.2 Funct
Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
604 10 3 7 3.9 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)N3CC[N+](CC3)(C)CC4=CC5=C(C=C4)OCO5
CHEMBL3085090 acm3_human Human No 8.0 IC50 = 10.9 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
356 5 0 4 4.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=CC=C3)C4=CSC=C4
CHEMBL3085090 acm3_human Human No 8.0 IC50 = 10.9 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
356 5 0 4 4.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=CC=C3)C4=CSC=C4
CHEMBL492997 acm3_human Human No 7.0 IC50 = 100 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
420 6 2 3 4.1 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC(=CC=C4)Cl
CHEMBL451040 acm3_human Human No 7.0 IC50 = 100 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
569 10 5 6 3.4 CC(C)NC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)C#N
CHEMBL451043 acm3_human Human No 7.0 IC50 = 100 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
573 12 5 7 3.9 C1CC1COC(=O)C2=CC=C(C=C2)NC(=O)NC(CC3=CC=C(C=C3)O)C(=O)NC4CCN(C4)CC5=CC=C(C=C5)O
CHEMBL1290183 acm3_human Human No 7.0 IC50 = 100 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
383 3 0 2 4.6 C1CN(CCC12CCN(CC2)C(=O)C3=CC=CC=C3)CC4=CC(=CC=C4)Cl
CHEMBL1290184 acm3_human Human No 7.0 IC50 = 100 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
363 3 0 2 4.4 CC1=CC(=CC=C1)CN2CCC3(CC2)CCN(CC3)C(=O)C4=CC=CC=C4
CHEMBL1289201 acm3_human Human No 7.0 IC50 = 100 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
405 4 1 5 2.1 C1CN(CCC12CN(CCO2)C(=O)C3=CC=C(O3)CO)CC4=CC=C(C=C4)Cl
CHEMBL492997 acm3_human Human No 7.0 IC50 = 100 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
420 6 2 3 4.1 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC(=CC=C4)Cl
CHEMBL451040 acm3_human Human No 7.0 IC50 = 100 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
569 10 5 6 3.4 CC(C)NC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)C#N
CHEMBL451043 acm3_human Human No 7.0 IC50 = 100 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
573 12 5 7 3.9 C1CC1COC(=O)C2=CC=C(C=C2)NC(=O)NC(CC3=CC=C(C=C3)O)C(=O)NC4CCN(C4)CC5=CC=C(C=C5)O
CHEMBL1290183 acm3_human Human No 7.0 IC50 = 100 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
383 3 0 2 4.6 C1CN(CCC12CCN(CC2)C(=O)C3=CC=CC=C3)CC4=CC(=CC=C4)Cl
CHEMBL1290184 acm3_human Human No 7.0 IC50 = 100 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
363 3 0 2 4.4 CC1=CC(=CC=C1)CN2CCC3(CC2)CCN(CC3)C(=O)C4=CC=CC=C4
CHEMBL1289201 acm3_human Human No 7.0 IC50 = 100 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
405 4 1 5 2.1 C1CN(CCC12CN(CCO2)C(=O)C3=CC=C(O3)CO)CC4=CC=C(C=C4)Cl
CHEMBL3087239 acm3_human Human No 7.0 IC50 = 100 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
444 6 0 4 3.5 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)N5CCOCC5
CHEMBL495361 acm3_human Human No 6.0 IC50 = 1000 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
420 6 2 3 4.1 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC=CC=C4Cl
CHEMBL458105 acm3_human Human No 6.0 IC50 = 1000 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
597 9 4 7 2.4 C1CN(CC1NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)NC3=CC=C(C=C3)C(=O)N4CCOCC4)CC5=CC=C(C=C5)C#N
CHEMBL1083108 acm3_human Human No 6.0 IC50 = 1000 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
347 4 2 3 3.9 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=C(C=CC(=C3)Cl)F
CHEMBL495361 acm3_human Human No 6.0 IC50 = 1000 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
420 6 2 3 4.1 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC=CC=C4Cl
CHEMBL458105 acm3_human Human No 6.0 IC50 = 1000 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
597 9 4 7 2.4 C1CN(CC1NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)NC3=CC=C(C=C3)C(=O)N4CCOCC4)CC5=CC=C(C=C5)C#N
CHEMBL296405 acm3_rat Rat No 6.0 IC50 = 1000 Funct
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligand
436 7 1 5 2.3 CCN(CC)CCC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL296988 acm3_rat Rat No 6.0 IC50 = 1000 Funct
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligand
393 4 1 5 1.2 CN(C)CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL297224 acm3_rat Rat No 6.0 IC50 = 1000 Funct
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligand
436 6 1 5 2.3 CCN(CC)CC1CCCCN1CC(=O)N2C3=C(C=C(C=C3)C)C(=O)NC4=C2N=CC=C4
CHEMBL1083108 acm3_human Human No 6.0 IC50 = 1000 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
347 4 2 3 3.9 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=C(C=CC(=C3)Cl)F
CHEMBL296405 acm3_rat Rat No 6.0 IC50 = 1000 Funct
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesInhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates
436 7 1 5 2.3 CCN(CC)CCC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL296988 acm3_rat Rat No 6.0 IC50 = 1000 Funct
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesInhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates
393 4 1 5 1.2 CN(C)CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL297224 acm3_rat Rat No 6.0 IC50 = 1000 Funct
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesInhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates
436 6 1 5 2.3 CCN(CC)CC1CCCCN1CC(=O)N2C3=C(C=C(C=C3)C)C(=O)NC4=C2N=CC=C4
CHEMBL1083002 acm3_human Human No 5.0 IC50 = 10000 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
375 5 2 3 4.7 CCC1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL1083003 acm3_human Human No 5.0 IC50 = 10000 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
365 4 2 4 3.9 C1CNCC(C1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl)F
CHEMBL1083317 acm3_human Human No 5.0 IC50 = 10000 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
397 4 2 4 3.6 C1CNCC(=C1CNC(=O)C2=C(C=CC(=C2F)Cl)C3=CC(=CC=C3)Cl)F
CHEMBL1083002 acm3_human Human No 5.0 IC50 = 10000 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
375 5 2 3 4.7 CCC1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL1083003 acm3_human Human No 5.0 IC50 = 10000 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
365 4 2 4 3.9 C1CNCC(C1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl)F
CHEMBL1083317 acm3_human Human No 5.0 IC50 = 10000 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
397 4 2 4 3.6 C1CNCC(=C1CNC(=O)C2=C(C=CC(=C2F)Cl)C3=CC(=CC=C3)Cl)F
CHEMBL15936 acm3_human Human No 4.0 IC50 = 100000 Funct
Compound was evaluated for its ability to displace [3H]N-methylscopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M3Compound was evaluated for its ability to displace [3H]N-methylscopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M3
191 0 1 4 1.2 C1CNCC2=C1C=CC3=NSN=C23
CHEMBL61494 acm3_human Human No 5.0 IC50 = 10315.1 Funct
Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
408 5 1 6 3.5 CCOC(=O)C1=CNC2=C1C3=C(C=C2)OC4C5=CC(=C(C=C5CCN4C3)OC)OC
CHEMBL2306159 acm3_human Human No 6.0 IC50 = 1059 Funct
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
475 8 1 4 6.1 CN1C2CCC1CC(C2)CC(CNS(=O)(=O)C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL2306159 acm3_human Human No 6.0 IC50 = 1059 Funct
Antagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
475 8 1 4 6.1 CN1C2CCC1CC(C2)CC(CNS(=O)(=O)C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL2306159 acm3_human Human No 6.0 IC50 = 1059 Funct
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
475 8 1 4 6.1 CN1C2CCC1CC(C2)CC(CNS(=O)(=O)C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL2306159 acm3_human Human No 6.0 IC50 = 1059 Funct
Antagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
475 8 1 4 6.1 CN1C2CCC1CC(C2)CC(CNS(=O)(=O)C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL3401657 acm3_human Human No 6.0 IC50 = 1069.4 Funct
Displacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
348 4 2 5 2.1 C1CN2CCC1C(C2)NC(=O)C(C3=CC=CS3)(C4=CC=CS4)O
CHEMBL3401657 acm3_human Human No 6.0 IC50 = 1069.4 Funct
Displacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
348 4 2 5 2.1 C1CN2CCC1C(C2)NC(=O)C(C3=CC=CS3)(C4=CC=CS4)O
CHEMBL3085086 acm3_human Human No 7.0 IC50 = 108 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
371 5 0 4 4.5 CC1=C(SC=C1)CN(C2=CC=CC=C2)C(=O)OC3CC4CCC(C3)N4C
CHEMBL3085086 acm3_human Human No 7.0 IC50 = 108 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
371 5 0 4 4.5 CC1=C(SC=C1)CN(C2=CC=CC=C2)C(=O)OC3CC4CCC(C3)N4C
CHEMBL300987 acm3_human Human No 5.0 IC50 = 10804.1 Funct
Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
392 4 1 5 3.9 CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=CC(=C5)OC)C
CHEMBL3085092 acm3_human Human No 7.0 IC50 = 109 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
363 5 0 4 4.9 CN1C2CCC1CC(C2)OC(=O)N(CC3CCCCC3)C4=CSC=C4
CHEMBL3085092 acm3_human Human No 7.0 IC50 = 109 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
363 5 0 4 4.9 CN1C2CCC1CC(C2)OC(=O)N(CC3CCCCC3)C4=CSC=C4
CHEMBL3401642 acm3_human Human No 7.0 IC50 = 110 Funct
Displacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
332 4 1 4 2.9 C1CN2CCC1C(C2)NC(=O)C(C3=CC=CS3)C4=CC=CS4
CHEMBL3401642 acm3_human Human No 7.0 IC50 = 110 Funct
Displacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
332 4 1 4 2.9 C1CN2CCC1C(C2)NC(=O)C(C3=CC=CS3)C4=CC=CS4
CHEMBL450986 acm3_human Human Yes 6.0 IC50 = 1100 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in insect Sf9 cellsDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in insect Sf9 cells
786 25 5 11 7.2 CCCCCCCCCCCCCC(C(C)C(=O)NC1CCCCN(C1=O)O)OC(=O)C(CCCCN(C(=O)C)O)NC(=O)C2=COC(=C3C=CC=CC3=O)N2
CHEMBL450986 acm3_human Human Yes 6.0 IC50 = 1100 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in insect Sf9 cellsDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in insect Sf9 cells
786 25 5 11 7.2 CCCCCCCCCCCCCC(C(C)C(=O)NC1CCCCN(C1=O)O)OC(=O)C(CCCCN(C(=O)C)O)NC(=O)C2=COC(=C3C=CC=CC3=O)N2
CHEMBL496376 acm3_human Human No 5.0 IC50 = 11000 Funct
Binding affinity to human muscarinic M3 receptorBinding affinity to human muscarinic M3 receptor
470 6 1 3 4.4 C1CC(CN(C1)CC(=O)N)(C2CCN(CC2)CC3=CC=C(C=C3)Br)C4=CC=CC=C4
CHEMBL496376 acm3_human Human No 5.0 IC50 = 11000 Funct
Binding affinity to human muscarinic M3 receptorBinding affinity to human muscarinic M3 receptor
470 6 1 3 4.4 C1CC(CN(C1)CC(=O)N)(C2CCN(CC2)CC3=CC=C(C=C3)Br)C4=CC=CC=C4
CHEMBL7303 acm3_human Human Yes 5.0 IC50 = 11000 Funct
In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M3In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M3
155 2 0 3 0.3 CN1CCC=C(C1)C(=O)OC
CHEMBL3085082 acm3_human Human No 5.9 IC50 = 1143.6 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
429 5 0 3 5.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=CC=C3Br)C4=CC=CC=C4
CHEMBL3085082 acm3_human Human No 5.9 IC50 = 1143.6 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
429 5 0 3 5.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=CC=C3Br)C4=CC=CC=C4
CHEMBL3085083 acm3_human Human No 5.9 IC50 = 1161.3 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
375 5 0 4 4.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=C(C=C3)C#N)C4=CC=CC=C4
CHEMBL3085083 acm3_human Human No 5.9 IC50 = 1161.3 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
375 5 0 4 4.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=C(C=C3)C#N)C4=CC=CC=C4
CHEMBL1084851 acm3_human Human No 7.9 IC50 = 12.6 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
312 4 1 1 5.4 C1CNCCC1CC=CC2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL3087245 acm3_human Human No 7.9 IC50 = 12.6 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
441 7 1 5 4.0 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)NC5=NC=CO5
CHEMBL1084851 acm3_human Human No 7.9 IC50 = 12.6 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
312 4 1 1 5.4 C1CNCCC1CC=CC2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL135328 acm3_human Human No 5.9 IC50 = 1200 Funct
In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M3In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M3
179 2 0 4 0.6 CON=C(C#N)C1CN2CCC1C2
CHEMBL1290294 acm3_human Human No 6.9 IC50 = 125.9 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
348 3 0 2 4.0 C1CN(CCC12CCN(CC2)C(=O)C3=CC=CC=C3)CC4=CC=CC=C4
CHEMBL1289202 acm3_human Human No 6.9 IC50 = 125.9 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
375 3 0 4 2.6 C1CN(CCC12CN(CCO2)C(=O)C3=COC=C3)CC4=CC=C(C=C4)Cl
CHEMBL1084804 acm3_human Human No 6.9 IC50 = 125.9 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
329 4 2 2 3.5 C1CNCCC1NC(=O)CC2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL1290294 acm3_human Human No 6.9 IC50 = 125.9 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
348 3 0 2 4.0 C1CN(CCC12CCN(CC2)C(=O)C3=CC=CC=C3)CC4=CC=CC=C4
CHEMBL1289202 acm3_human Human No 6.9 IC50 = 125.9 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
375 3 0 4 2.6 C1CN(CCC12CN(CCO2)C(=O)C3=COC=C3)CC4=CC=C(C=C4)Cl
CHEMBL1084804 acm3_human Human No 6.9 IC50 = 125.9 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
329 4 2 2 3.5 C1CNCCC1NC(=O)CC2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL7568 acm3_human Human Yes 5.9 IC50 = 1255 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
400 9 1 4 6.0 CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC
CHEMBL7568 acm3_human Human Yes 5.9 IC50 = 1255 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
400 9 1 4 6.0 CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC
CHEMBL492391 acm3_human Human No 5.9 IC50 = 1258.9 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
478 8 2 4 5.0 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC(=CC=C4)OC5=CC=CC=C5
CHEMBL522992 acm3_human Human No 5.9 IC50 = 1258.9 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
460 7 2 6 3.3 COC1=C(C=C(C=C1)CN2CCNCC2)C3=CC(=CC=C3)CNC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL1085985 acm3_human Human No 5.9 IC50 = 1258.9 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
365 4 2 4 3.8 C1CNCCC1(CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl)F
CHEMBL1084993 acm3_human Human No 5.9 IC50 = 1258.9 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
343 4 2 2 4.2 CC1CNCCC1CNC(=O)C2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL1083404 acm3_human Human No 5.9 IC50 = 1258.9 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
381 4 2 3 4.5 C1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=C(C=CC(=C3)Cl)Cl
CHEMBL492391 acm3_human Human No 5.9 IC50 = 1258.9 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
478 8 2 4 5.0 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC(=CC=C4)OC5=CC=CC=C5
CHEMBL522992 acm3_human Human No 5.9 IC50 = 1258.9 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
460 7 2 6 3.3 COC1=C(C=C(C=C1)CN2CCNCC2)C3=CC(=CC=C3)CNC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL1085985 acm3_human Human No 5.9 IC50 = 1258.9 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
365 4 2 4 3.8 C1CNCCC1(CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl)F
CHEMBL1084993 acm3_human Human No 5.9 IC50 = 1258.9 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
343 4 2 2 4.2 CC1CNCCC1CNC(=O)C2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL1083404 acm3_human Human No 5.9 IC50 = 1258.9 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
381 4 2 3 4.5 C1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=C(C=CC(=C3)Cl)Cl
CHEMBL480464 acm3_human Human No 6.9 IC50 = 126 Funct
Displacement of [3H]NMS from human cloned muscarinic M3 receptor expressed in insect Sf9 cellsDisplacement of [3H]NMS from human cloned muscarinic M3 receptor expressed in insect Sf9 cells
255 6 1 4 2.2 CCC(C)C(C(=O)OCC1CCN2C1CCC2)O
CHEMBL480464 acm3_human Human No 6.9 IC50 = 126 Funct
Displacement of [3H]NMS from human cloned muscarinic M3 receptor expressed in insect Sf9 cellsDisplacement of [3H]NMS from human cloned muscarinic M3 receptor expressed in insect Sf9 cells
255 6 1 4 2.2 CCC(C)C(C(=O)OCC1CCN2C1CCC2)O
CHEMBL61774 acm3_human Human No 4.9 IC50 = 12612.2 Funct
Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
348 2 1 4 3.5 CC1=C(C2=C(N1)C=CC3=C2CN4CCC5=CC=CC=C5C4O3)C(=O)OC
CHEMBL2207177 acm3_human Human No 7.9 IC50 = 13.3 Funct
Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
622 11 3 5 5.5 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)N3CCCC(C3)[N+](C)(C)CC4=CC=C(C=C4)Cl
CHEMBL322378 acm3_rat Rat No 5.9 IC50 = 1300 Funct
Displacement of [3H]methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.Displacement of [3H]methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.
391 5 1 3 4.4 CC1=C(C=CC(=C1)C(=O)C2=CC=CC=C2)NC(=O)CC3CCCN4C3CCCC4
CHEMBL2307674 acm3_human Human No 5.9 IC50 = 1338 Funct
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
468 8 2 2 6.0 CN1C2CCC1CC(C2)CC(CNC(=O)NCC3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL2307674 acm3_human Human No 5.9 IC50 = 1338 Funct
Antagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
468 8 2 2 6.0 CN1C2CCC1CC(C2)CC(CNC(=O)NCC3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL2307674 acm3_human Human No 5.9 IC50 = 1338 Funct
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
468 8 2 2 6.0 CN1C2CCC1CC(C2)CC(CNC(=O)NCC3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL2307674 acm3_human Human No 5.9 IC50 = 1338 Funct
Antagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
468 8 2 2 6.0 CN1C2CCC1CC(C2)CC(CNC(=O)NCC3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL3084394 acm3_human Human No 6.9 IC50 = 134 Funct
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
335 5 1 2 4.7 CN1C2CCC1CC(C2)CCC(C3=CC=CC=C3)(C4=CC=CC=C4)O
CHEMBL3084394 acm3_human Human No 6.9 IC50 = 134 Funct
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
335 5 1 2 4.7 CN1C2CCC1CC(C2)CCC(C3=CC=CC=C3)(C4=CC=CC=C4)O
CHEMBL3084397 acm3_human Human No 6.9 IC50 = 135 Funct
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
273 4 1 2 3.5 CCC(CC1CC2CCC(C1)N2C)(C3=CC=CC=C3)O
CHEMBL3084397 acm3_human Human No 6.9 IC50 = 135 Funct
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
273 4 1 2 3.5 CCC(CC1CC2CCC(C1)N2C)(C3=CC=CC=C3)O
CHEMBL3085093 acm3_human Human No 6.9 IC50 = 136.9 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
381 5 0 5 3.8 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=C(C=C3)C#N)C4=CSC=C4
CHEMBL3085093 acm3_human Human No 6.9 IC50 = 136.9 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
381 5 0 5 3.8 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=C(C=C3)C#N)C4=CSC=C4
CHEMBL1200604 acm3_human Human Yes 6.9 IC50 = 142 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
284 6 1 3 1.5 CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2
CHEMBL1200604 acm3_human Human Yes 6.9 IC50 = 142 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
284 6 1 3 1.5 CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2
CHEMBL2206603 acm3_human Human No 6.9 IC50 = 142.6 Funct
Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
582 13 4 5 4.7 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NCC[N+](C)(C)CC3=CC=C(C=C3)Cl
CHEMBL1306 acm3_human Human Yes 4.8 IC50 = 14537 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
532 8 0 7 4.8 CC(C)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=NC=N4)C5=C(C=C(C=C5)Cl)Cl
CHEMBL1306 acm3_human Human Yes 4.8 IC50 = 14537 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
532 8 0 7 4.8 CC(C)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=NC=N4)C5=C(C=C(C=C5)Cl)Cl
CHEMBL30008 acm3_human Human Yes 5.8 IC50 = 1479 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
405 6 0 4 6.0 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
CHEMBL61412 acm3_human Human No 5.8 IC50 = 1482.3 Funct
Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
406 5 1 5 4.4 CCCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=C(C=C5)OC)C
CHEMBL7002 acm3_human Human Yes 4.8 IC50 = 14947 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
333 5 1 4 4.8 CC1(CCCCC1)COC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL7002 acm3_human Human Yes 4.8 IC50 = 14947 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
333 5 1 4 4.8 CC1(CCCCC1)COC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL3084393 acm3_human Human No 5.8 IC50 = 1498 Funct
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
307 3 1 2 4.0 CN1C2CCC1CC(C2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O
CHEMBL3084393 acm3_human Human No 5.8 IC50 = 1498 Funct
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
307 3 1 2 4.0 CN1C2CCC1CC(C2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O
CHEMBL3401640 acm3_human Human No 7.8 IC50 = 15 Funct
Displacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
336 4 2 3 2.7 C1CN2CCC1C(C2)NC(=O)C(C3=CC=CC=C3)(C4=CC=CC=C4)O
CHEMBL1779043 acm3_human Human No 7.8 IC50 = 15 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
354 5 0 4 3.9 C1CN2CCC1C(C2)OC(=O)N(CC3=CC=CC=C3)C4=CC=C(C=C4)F
CHEMBL3401640 acm3_human Human No 7.8 IC50 = 15 Funct
Displacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
336 4 2 3 2.7 C1CN2CCC1C(C2)NC(=O)C(C3=CC=CC=C3)(C4=CC=CC=C4)O
CHEMBL1779043 acm3_human Human No 7.8 IC50 = 15 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
354 5 0 4 3.9 C1CN2CCC1C(C2)OC(=O)N(CC3=CC=CC=C3)C4=CC=C(C=C4)F
CHEMBL526009 acm3_human Human No 7.8 IC50 = 15.9 Funct
Antagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL480878 acm3_human Human No 7.8 IC50 = 15.9 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
531 11 4 6 3.9 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=CC=C4
CHEMBL526009 acm3_human Human No 7.8 IC50 = 15.9 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL443925 acm3_human Human No 7.8 IC50 = 15.9 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
599 11 4 9 4.7 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC(=CC=C4)C(F)(F)F
CHEMBL1289758 acm3_human Human No 7.8 IC50 = 15.9 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
420 4 0 5 3.7 CCC1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=C(C=C4)Cl
CHEMBL1289865 acm3_human Human No 7.8 IC50 = 15.9 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
434 4 0 5 4.1 CC(C)C1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=C(C=C4)Cl
CHEMBL526009 acm3_human Human No 7.8 IC50 = 15.9 Funct
Antagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL480878 acm3_human Human No 7.8 IC50 = 15.9 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
531 11 4 6 3.9 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=CC=C4
CHEMBL526009 acm3_human Human No 7.8 IC50 = 15.9 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL443925 acm3_human Human No 7.8 IC50 = 15.9 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
599 11 4 9 4.7 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC(=CC=C4)C(F)(F)F
CHEMBL1289758 acm3_human Human No 7.8 IC50 = 15.9 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
420 4 0 5 3.7 CCC1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=C(C=C4)Cl
CHEMBL1289865 acm3_human Human No 7.8 IC50 = 15.9 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
434 4 0 5 4.1 CC(C)C1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=C(C=C4)Cl
CHEMBL44773 acm3_rat Rat No 6.8 IC50 = 150 Funct
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligand
462 5 1 5 3.0 CN(CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4)C5CCCCC5
CHEMBL44773 acm3_rat Rat No 6.8 IC50 = 150 Funct
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesInhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates
462 5 1 5 3.0 CN(CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4)C5CCCCC5
CHEMBL297818 acm3_rat Rat No 5.8 IC50 = 1500 Funct
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligand
456 6 1 5 2.6 CCN(CC)CC1CCCCN1CC(=O)N2C3=C(C=CC(=C3)Cl)C(=O)NC4=C2N=CC=C4
CHEMBL410928 acm3_rat Rat No 5.8 IC50 = 1500 Funct
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligand
420 4 1 5 1.7 C1CCN(C(C1)CN2CCCC2)CC(=O)N3C4=CC=CC=C4C(=O)NC5=C3N=CC=C5
CHEMBL49525 acm3_rat Rat No 5.8 IC50 = 1500 Funct
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligand
408 5 1 5 1.6 CCN(C)CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL45983 acm3_rat Rat No 5.8 IC50 = 1500 Funct
Binding affinity of compound for glandular Muscarinic acetylcholine receptor M3 in rat using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity of compound for glandular Muscarinic acetylcholine receptor M3 in rat using 0.3 nM [3H]N-methylscopolamine as radioligand
434 4 1 5 2.1 C1CCN(CC1)CC2CCCCN2CC(=O)N3C4=CC=CC=C4C(=O)NC5=C3N=CC=C5
CHEMBL297818 acm3_rat Rat No 5.8 IC50 = 1500 Funct
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesInhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates
456 6 1 5 2.6 CCN(CC)CC1CCCCN1CC(=O)N2C3=C(C=CC(=C3)Cl)C(=O)NC4=C2N=CC=C4
CHEMBL410928 acm3_rat Rat No 5.8 IC50 = 1500 Funct
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesInhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates
420 4 1 5 1.7 C1CCN(C(C1)CN2CCCC2)CC(=O)N3C4=CC=CC=C4C(=O)NC5=C3N=CC=C5
CHEMBL45983 acm3_rat Rat No 5.8 IC50 = 1500 Funct
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesInhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates
434 4 1 5 2.1 C1CCN(CC1)CC2CCCCN2CC(=O)N3C4=CC=CC=C4C(=O)NC5=C3N=CC=C5
CHEMBL49525 acm3_rat Rat No 5.8 IC50 = 1500 Funct
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesInhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates
408 5 1 5 1.6 CCN(C)CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL44838 acm3_rat Rat No 4.8 IC50 = 15000 Funct
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligand
436 6 1 5 2.3 CCN(CC)CC1CCCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL44838 acm3_rat Rat No 4.8 IC50 = 15000 Funct
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesInhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates
436 6 1 5 2.3 CCN(CC)CC1CCCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL728 acm3_human Human Yes 5.8 IC50 = 1514 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
374 4 0 4 4.9 CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL294726 acm3_human Human No 4.8 IC50 = 15293.8 Funct
Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
320 1 1 3 3.7 CC1=CC2=C(N1)C=CC3=C2CN4CCC5=C(C4O3)C=CC(=C5)OC
CHEMBL461571 acm3_human Human No 5.8 IC50 = 1560 Funct
Displacement of radioligand from muscarinic M3 receptorDisplacement of radioligand from muscarinic M3 receptor
532 8 1 8 7.1 CC1=C(C2=C(N1CC3=CC(=CC=C3)OC(C)C(=O)O)C=C(C=C2)OC(F)(F)F)C(=O)C4=CC=C(C=C4)Cl
CHEMBL461571 acm3_human Human No 5.8 IC50 = 1560 Funct
Displacement of radioligand from muscarinic M3 receptorDisplacement of radioligand from muscarinic M3 receptor
532 8 1 8 7.1 CC1=C(C2=C(N1CC3=CC(=CC=C3)OC(C)C(=O)O)C=C(C=C2)OC(F)(F)F)C(=O)C4=CC=C(C=C4)Cl
CHEMBL448904 acm3_human Human No 6.8 IC50 = 158.5 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
581 11 5 6 3.4 C1CC1CNC(=O)C2=CC=C(C=C2)NC(=O)NC(CC3=CC=C(C=C3)O)C(=O)NC4CCN(C4)CC5=CC=C(C=C5)C#N
CHEMBL1289544 acm3_human Human No 6.8 IC50 = 158.5 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
392 3 0 5 2.9 C1CN(CCC12CN(CCO2)C(=O)C3=CSC=N3)CC4=CC=C(C=C4)Cl
CHEMBL1924035 acm3_human Human No 6.8 IC50 = 158.5 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
362 9 0 3 4.5 CCCN(CCC)C(C)(C1=CC=CC=C1)C(=O)OC2CC[N+](CC2)(C)C
CHEMBL448904 acm3_human Human No 6.8 IC50 = 158.5 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
581 11 5 6 3.4 C1CC1CNC(=O)C2=CC=C(C=C2)NC(=O)NC(CC3=CC=C(C=C3)O)C(=O)NC4CCN(C4)CC5=CC=C(C=C5)C#N
CHEMBL1289544 acm3_human Human No 6.8 IC50 = 158.5 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
392 3 0 5 2.9 C1CN(CCC12CN(CCO2)C(=O)C3=CSC=N3)CC4=CC=C(C=C4)Cl
CHEMBL1924035 acm3_human Human No 6.8 IC50 = 158.5 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
362 9 0 3 4.5 CCCN(CCC)C(C)(C1=CC=CC=C1)C(=O)OC2CC[N+](CC2)(C)C
CHEMBL2206609 acm3_human Human No 6.8 IC50 = 158.9 Funct
Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
526 11 4 5 3.8 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NCC[N+]3(CCCCCC3)C
CHEMBL502000 acm3_human Human No 5.8 IC50 = 1584.9 Funct
Antagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL494996 acm3_human Human No 5.8 IC50 = 1584.9 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
458 7 1 5 4.1 CCN1CCN(CC1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL507581 acm3_human Human No 5.8 IC50 = 1584.9 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
617 11 5 6 4.1 C1CN(CC1NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)NC3=CC=C(C=C3)C(=O)NCC4=CC=CC=C4)CC5=CC=C(C=C5)C#N
CHEMBL502000 acm3_human Human No 5.8 IC50 = 1584.9 Funct
Antagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL494996 acm3_human Human No 5.8 IC50 = 1584.9 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
458 7 1 5 4.1 CCN1CCN(CC1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL507581 acm3_human Human No 5.8 IC50 = 1584.9 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
617 11 5 6 4.1 C1CN(CC1NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)NC3=CC=C(C=C3)C(=O)NCC4=CC=CC=C4)CC5=CC=C(C=C5)C#N
CHEMBL15944 acm3_human Human No 5.8 IC50 = 1600 Funct
Compound was evaluated for its ability to displace [3H]N-methylscopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M3Compound was evaluated for its ability to displace [3H]N-methylscopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M3
227 2 0 5 1.5 CN1CCC=C(C1)C2=NSN=C2SC
CHEMBL120972 acm3_human Human No 5.8 IC50 = 1600.8 Funct
Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M3 using membranes from transfected CHO cellsDisplacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M3 using membranes from transfected CHO cells
358 12 0 3 6.0 CCCCCCCCCOC(=O)C1CN(CC=C1C2=CC=CC=C2)CC
CHEMBL58228 acm3_human Human No 5.8 IC50 = 1616.4 Funct
Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
422 5 1 6 3.9 CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=CC(=C(C=C5CCN4C3)OC)OC)C
CHEMBL1779041 acm3_human Human No 7.8 IC50 = 17.7 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
322 7 0 4 3.2 CCCCN(CC1=CC=CS1)C(=O)OC2CN3CCC2CC3
CHEMBL1779041 acm3_human Human No 7.8 IC50 = 17.7 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
322 7 0 4 3.2 CCCCN(CC1=CC=CS1)C(=O)OC2CN3CCC2CC3
CHEMBL415 acm3_human Human Yes 6.8 IC50 = 170 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
315 4 0 2 5.2 CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl
CHEMBL415 acm3_human Human Yes 6.8 IC50 = 170 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
315 4 0 2 5.2 CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl
CHEMBL445 acm3_human Human Yes 6.8 IC50 = 171 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
263 3 1 1 4.5 CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
CHEMBL3401647 acm3_human Human No 6.8 IC50 = 172.5 Funct
Displacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
348 2 0 3 3.2 CN(C1CN2CCC1CC2)C(=O)C3C4=CC=CC=C4OC5=CC=CC=C35
CHEMBL3401647 acm3_human Human No 6.8 IC50 = 172.5 Funct
Displacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
348 2 0 3 3.2 CN(C1CN2CCC1CC2)C(=O)C3C4=CC=CC=C4OC5=CC=CC=C35
CHEMBL900 acm3_human Human Yes 6.8 IC50 = 175 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
269 6 0 2 3.8 CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C
CHEMBL900 acm3_human Human Yes 6.8 IC50 = 175 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
269 6 0 2 3.8 CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C
CHEMBL1479 acm3_human Human Yes 4.8 IC50 = 17747 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
337 1 1 3 3.8 CC12CCC3C(C1CCC2(C#C)O)CCC4=CC5=C(CC34C)C=NO5
CHEMBL1113 acm3_human Human Yes 5.8 IC50 = 1781 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
314 1 1 3 2.6 C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
CHEMBL808 acm3_human Human Yes 5.8 IC50 = 1789 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
382 6 0 2 5.3 C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
CHEMBL490 acm3_human Human Yes 6.8 IC50 = 179 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
329 4 1 5 3.5 C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4
CHEMBL490 acm3_human Human Yes 6.8 IC50 = 179 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
329 4 1 5 3.5 C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4
CHEMBL3401645 acm3_human Human No 7.7 IC50 = 18.7 Funct
Displacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
334 2 2 3 2.4 C1CN2CCC1C(C2)NC(=O)C3(C4=CC=CC=C4C5=CC=CC=C53)O
CHEMBL3401645 acm3_human Human No 7.7 IC50 = 18.7 Funct
Displacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
334 2 2 3 2.4 C1CN2CCC1C(C2)NC(=O)C3(C4=CC=CC=C4C5=CC=CC=C53)O
CHEMBL411 acm3_human Human Yes 4.7 IC50 = 18432 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
268 4 2 2 5.1 CCC(=C(CC)C1=CC=C(C=C1)O)C2=CC=C(C=C2)O
CHEMBL411 acm3_human Human Yes 4.7 IC50 = 18432 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
268 4 2 2 5.1 CCC(=C(CC)C1=CC=C(C=C1)O)C2=CC=C(C=C2)O
CHEMBL3084395 acm3_human Human No 7.7 IC50 = 19 Funct
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
322 4 1 3 3.3 CN1C2CCC1CC(C2)CC(C3=CC=CC=C3)(C4=CC=CC=N4)O
CHEMBL3670826 acm3_human Human No 7.7 IC50 = 19 Funct
Radioligand Binding Assay: Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). Incubations of test ligands (or standard) with 0.2 nM [3H]4-DAMP were incubated for 120 minutes at 22 C. using human M3 receptor-expressing cell homogenates. Specific ligand binding to the receptors was defined as the difference between the total radioligand binding and the nonspecific binding determined in the presence of an excess of unlabelled ligand (10 atropine). The results were expressed as a percent of control specific binding ((measured specific binding/control specific binding)x100) obtained in the presence of various concentrations of the test compounds.Radioligand Binding Assay: Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). Incubations of test ligands (or standard) with 0.2 nM [3H]4-DAMP were incubated for 120 minutes at 22 C. using human M3 receptor-expressing cell homogenates. Specific ligand binding to the receptors was defined as the difference between the total radioligand binding and the nonspecific binding determined in the presence of an excess of unlabelled ligand (10 atropine). The results were expressed as a percent of control specific binding ((measured specific binding/control specific binding)x100) obtained in the presence of various concentrations of the test compounds.
344 5 1 3 3.7 C[N+]1(C2CCC1C(C2)OC(=O)C(C3CCCC3)(C4=CC=CC=C4)O)C
CHEMBL3084395 acm3_human Human No 7.7 IC50 = 19 Funct
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
322 4 1 3 3.3 CN1C2CCC1CC(C2)CC(C3=CC=CC=C3)(C4=CC=CC=N4)O
CHEMBL505452 acm3_human Human No 7.7 IC50 = 20.0 Funct
Antagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL492374 acm3_human Human No 7.7 IC50 = 20.0 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
444 8 2 5 3.4 COC(=O)C1=CC=CC(=C1)C(=O)NCC2=CC=CC(=C2)C3=CC(=CC=C3)CN4CCNCC4
CHEMBL494749 acm3_human Human No 7.7 IC50 = 20.0 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
464 7 2 5 2.7 CS(=O)(=O)C1=CC=CC(=C1)C(=O)NCC2=CC=CC(=C2)C3=CC(=CC=C3)CN4CCNCC4
CHEMBL480299 acm3_human Human No 7.7 IC50 = 20.0 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
561 12 4 7 3.8 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)OC
CHEMBL505452 acm3_human Human No 7.7 IC50 = 20.0 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL518001 acm3_human Human No 7.7 IC50 = 20.0 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC(=CC=C4)O
CHEMBL1289982 acm3_human Human No 7.7 IC50 = 20.0 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
434 4 0 5 4.1 CC(C)C1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=CC=C4Cl
CHEMBL1083402 acm3_human Human No 7.7 IC50 = 20.0 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
364 5 1 3 4.1 C1CNCCC1CCS(=O)(=O)C2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL505452 acm3_human Human No 7.7 IC50 = 20.0 Funct
Antagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL492374 acm3_human Human No 7.7 IC50 = 20.0 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
444 8 2 5 3.4 COC(=O)C1=CC=CC(=C1)C(=O)NCC2=CC=CC(=C2)C3=CC(=CC=C3)CN4CCNCC4
CHEMBL494749 acm3_human Human No 7.7 IC50 = 20.0 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
464 7 2 5 2.7 CS(=O)(=O)C1=CC=CC(=C1)C(=O)NCC2=CC=CC(=C2)C3=CC(=CC=C3)CN4CCNCC4
CHEMBL480299 acm3_human Human No 7.7 IC50 = 20.0 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
561 12 4 7 3.8 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)OC
CHEMBL505452 acm3_human Human No 7.7 IC50 = 20.0 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL518001 acm3_human Human No 7.7 IC50 = 20.0 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC(=CC=C4)O
CHEMBL1289982 acm3_human Human No 7.7 IC50 = 20.0 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
434 4 0 5 4.1 CC(C)C1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=CC=C4Cl
CHEMBL1083402 acm3_human Human No 7.7 IC50 = 20.0 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
364 5 1 3 4.1 C1CNCCC1CCS(=O)(=O)C2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL195437 acm3_human Human Yes 4.7 IC50 = 19004 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
206 7 1 1 5.3 CCCCCCCCC1=CC=C(C=C1)O
CHEMBL195437 acm3_human Human Yes 4.7 IC50 = 19004 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
206 7 1 1 5.3 CCCCCCCCC1=CC=C(C=C1)O
CHEMBL395110 acm3_human Human Yes 6.7 IC50 = 191 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
310 2 0 3 5.6 CN1CCCC(C1)CN2C3=CC=CC=C3SC4=CC=CC=C42
CHEMBL395110 acm3_human Human Yes 6.7 IC50 = 191 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
310 2 0 3 5.6 CN1CCCC(C1)CN2C3=CC=CC=C3SC4=CC=CC=C42
CHEMBL3084663 acm3_human Human No 5.7 IC50 = 1939 Funct
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
406 7 2 2 4.9 CCNC(=O)NCC(CC1CC2CCC(C1)N2C)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL3084663 acm3_human Human No 5.7 IC50 = 1939 Funct
Antagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
406 7 2 2 4.9 CCNC(=O)NCC(CC1CC2CCC(C1)N2C)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL3084663 acm3_human Human No 5.7 IC50 = 1939 Funct
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
406 7 2 2 4.9 CCNC(=O)NCC(CC1CC2CCC(C1)N2C)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL3084663 acm3_human Human No 5.7 IC50 = 1939 Funct
Antagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
406 7 2 2 4.9 CCNC(=O)NCC(CC1CC2CCC(C1)N2C)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL2206585 acm3_human Human No 6.7 IC50 = 197.3 Funct
Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
596 14 4 5 5.1 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NCCC[N+](C)(C)CC3=CC=C(C=C3)Cl
CHEMBL494950 acm3_human Human No 6.7 IC50 = 199.5 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
429 7 2 4 3.6 CN(C)C1=CC=CC(=C1)C(=O)NCC2=CC=CC(=C2)C3=CC(=CC=C3)CN4CCNCC4
CHEMBL492359 acm3_human Human No 6.7 IC50 = 199.5 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
448 6 2 6 3.4 C1CN(CCN1)CC2=C(C=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC5=C(C=C4)OCO5)F
CHEMBL494752 acm3_human Human No 6.7 IC50 = 199.5 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
443 7 3 4 2.7 CC(=O)NC1=CC=CC(=C1)C(=O)NCC2=CC=CC(=C2)C3=CC(=CC=C3)CN4CCNCC4
CHEMBL1289314 acm3_human Human No 6.7 IC50 = 199.5 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
393 3 0 6 2.3 C1CN(CCC12CN(CCO2)C(=O)C3=NSN=C3)CC4=CC=C(C=C4)Cl
CHEMBL494950 acm3_human Human No 6.7 IC50 = 199.5 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
429 7 2 4 3.6 CN(C)C1=CC=CC(=C1)C(=O)NCC2=CC=CC(=C2)C3=CC(=CC=C3)CN4CCNCC4
CHEMBL492359 acm3_human Human No 6.7 IC50 = 199.5 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
448 6 2 6 3.4 C1CN(CCN1)CC2=C(C=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC5=C(C=C4)OCO5)F
CHEMBL494752 acm3_human Human No 6.7 IC50 = 199.5 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
443 7 3 4 2.7 CC(=O)NC1=CC=CC(=C1)C(=O)NCC2=CC=CC(=C2)C3=CC(=CC=C3)CN4CCNCC4
CHEMBL1289314 acm3_human Human No 6.7 IC50 = 199.5 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
393 3 0 6 2.3 C1CN(CCC12CN(CCO2)C(=O)C3=NSN=C3)CC4=CC=C(C=C4)Cl
CHEMBL494951 acm3_human Human No 5.7 IC50 = 1995.3 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
401 6 3 4 2.8 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC(=CC=C4)N
CHEMBL501486 acm3_human Human No 5.7 IC50 = 1995.3 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
402 6 3 4 3.1 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC(=CC=C4)O
CHEMBL1085556 acm3_human Human No 5.7 IC50 = 1995.3 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
329 4 2 2 3.3 C1CNCCC1C(=O)NCC2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL494951 acm3_human Human No 5.7 IC50 = 1995.3 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
401 6 3 4 2.8 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC(=CC=C4)N
CHEMBL501486 acm3_human Human No 5.7 IC50 = 1995.3 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
402 6 3 4 3.1 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC(=CC=C4)O
CHEMBL1085556 acm3_human Human No 5.7 IC50 = 1995.3 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
329 4 2 2 3.3 C1CNCCC1C(=O)NCC2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL501727 acm3_human Human No 4.7 IC50 = 19952.6 Funct
Antagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL501727 acm3_human Human No 4.7 IC50 = 19952.6 Funct
Antagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL3670828 acm3_human Human No 8.7 IC50 = 2.1 Funct
Radioligand Binding Assay: Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). Incubations of test ligands (or standard) with 0.2 nM [3H]4-DAMP were incubated for 120 minutes at 22 C. using human M3 receptor-expressing cell homogenates. Specific ligand binding to the receptors was defined as the difference between the total radioligand binding and the nonspecific binding determined in the presence of an excess of unlabelled ligand (10 atropine). The results were expressed as a percent of control specific binding ((measured specific binding/control specific binding)x100) obtained in the presence of various concentrations of the test compounds.Radioligand Binding Assay: Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). Incubations of test ligands (or standard) with 0.2 nM [3H]4-DAMP were incubated for 120 minutes at 22 C. using human M3 receptor-expressing cell homogenates. Specific ligand binding to the receptors was defined as the difference between the total radioligand binding and the nonspecific binding determined in the presence of an excess of unlabelled ligand (10 atropine). The results were expressed as a percent of control specific binding ((measured specific binding/control specific binding)x100) obtained in the presence of various concentrations of the test compounds.
344 5 1 3 3.7 C[N+]1(C2CCC1C(C2)OC(=O)C(C3CCCC3)(C4=CC=CC=C4)O)C
CHEMBL3401641 acm3_human Human No 8.7 IC50 = 2.2 Funct
Displacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
348 4 2 5 2.1 C1CN2CCC1C(C2)NC(=O)C(C3=CC=CS3)(C4=CC=CS4)O
CHEMBL3401641 acm3_human Human No 8.7 IC50 = 2.2 Funct
Displacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
348 4 2 5 2.1 C1CN2CCC1C(C2)NC(=O)C(C3=CC=CS3)(C4=CC=CS4)O
CHEMBL1779044 acm3_human Human No 8.6 IC50 = 2.4 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
372 5 0 5 4.0 C1CN2CCC1C(C2)OC(=O)N(CC3=CC(=CC=C3)F)C4=CC(=CC=C4)F
CHEMBL1779044 acm3_human Human No 8.6 IC50 = 2.4 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
372 5 0 5 4.0 C1CN2CCC1C(C2)OC(=O)N(CC3=CC(=CC=C3)F)C4=CC(=CC=C4)F
CHEMBL1921920 acm3_human Human No 8.6 IC50 = 2.5 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
491 9 0 4 5.6 CC1=CC(=CC(=N1)C)CCC[N+]23CCC(CC2)C(C3)OC(=O)C(C)(C4=CC=CC=C4)N5CCCCC5
CHEMBL1924037 acm3_human Human No 8.6 IC50 = 2.5 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
380 5 0 3 4.2 CC(C1=CC=C(C=C1)Cl)(C(=O)OC2CC[N+](CC2)(C)C)N3CCCCC3
CHEMBL1921920 acm3_human Human No 8.6 IC50 = 2.5 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
491 9 0 4 5.6 CC1=CC(=CC(=N1)C)CCC[N+]23CCC(CC2)C(C3)OC(=O)C(C)(C4=CC=CC=C4)N5CCCCC5
CHEMBL1924037 acm3_human Human No 8.6 IC50 = 2.5 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
380 5 0 3 4.2 CC(C1=CC=C(C=C1)Cl)(C(=O)OC2CC[N+](CC2)(C)C)N3CCCCC3
CHEMBL3087365 acm3_human Human No 8.6 IC50 = 2.5 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
451 7 1 4 4.2 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)NC5=CC=NC=C5
CHEMBL3087945 acm3_human Human No 8.6 IC50 = 2.5 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
520 7 1 8 4.4 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)NC5=NN=C(C=C5)C(F)(F)F
CHEMBL3087374 acm3_human Human No 8.6 IC50 = 2.5 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
519 7 1 7 5.5 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)NC5=CC=CC(=N5)C(F)(F)F
CHEMBL3088076 acm3_human Human No 8.6 IC50 = 2.5 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
330 4 0 2 4.4 C[N+]12CCC(CC1)C(C2)OC(=O)C3(CCCCCC3)C4=CC=CC4
CHEMBL1231 acm3_human Human Yes 8.6 IC50 = 2.7 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
357 8 1 4 4.2 CCN(CC)CC#CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O
CHEMBL1231 acm3_human Human Yes 8.6 IC50 = 2.7 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
357 8 1 4 4.2 CCN(CC)CC#CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O
CHEMBL3670828 acm3_human Human No 8.5 IC50 = 2.9 Funct
Radioligand Binding Assay: Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). Incubations of test ligands (or standard) with 0.2 nM [3H]4-DAMP were incubated for 120 minutes at 22 C. using human M3 receptor-expressing cell homogenates. Specific ligand binding to the receptors was defined as the difference between the total radioligand binding and the nonspecific binding determined in the presence of an excess of unlabelled ligand (10 atropine). The results were expressed as a percent of control specific binding ((measured specific binding/control specific binding)x100) obtained in the presence of various concentrations of the test compounds.Radioligand Binding Assay: Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). Incubations of test ligands (or standard) with 0.2 nM [3H]4-DAMP were incubated for 120 minutes at 22 C. using human M3 receptor-expressing cell homogenates. Specific ligand binding to the receptors was defined as the difference between the total radioligand binding and the nonspecific binding determined in the presence of an excess of unlabelled ligand (10 atropine). The results were expressed as a percent of control specific binding ((measured specific binding/control specific binding)x100) obtained in the presence of various concentrations of the test compounds.
344 5 1 3 3.7 C[N+]1(C2CCC1C(C2)OC(=O)C(C3CCCC3)(C4=CC=CC=C4)O)C
CHEMBL643 acm3_human Human Yes 7.7 IC50 = 20 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
284 3 0 3 4.8 CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C
CHEMBL643 acm3_human Human Yes 7.7 IC50 = 20 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
284 3 0 3 4.8 CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C
CHEMBL3085077 acm3_human Human No 7.7 IC50 = 20.3 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
356 5 0 4 4.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=CS3)C4=CC=CC=C4
CHEMBL3085077 acm3_human Human No 7.7 IC50 = 20.3 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
356 5 0 4 4.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=CS3)C4=CC=CC=C4
CHEMBL299142 acm3_rat Rat No 6.7 IC50 = 200 Funct
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligand
450 8 1 5 2.7 CCN(CC)CCCC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL300660 acm3_rat Rat No 6.7 IC50 = 200 Funct
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligand
436 7 1 5 2.5 CCCCN(C)CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL299142 acm3_rat Rat No 6.7 IC50 = 200 Funct
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesInhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates
450 8 1 5 2.7 CCN(CC)CCCC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL300660 acm3_rat Rat No 6.7 IC50 = 200 Funct
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesInhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates
436 7 1 5 2.5 CCCCN(C)CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL294919 acm3_rat Rat No 5.7 IC50 = 2000 Funct
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligand
436 6 1 5 2.3 CCN(CC)CC1CCCCN1CC(=O)N2C3=C(C=CC(=C3)C)C(=O)NC4=C2N=CC=C4
CHEMBL50176 acm3_rat Rat No 5.7 IC50 = 2000 Funct
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligand
450 7 1 5 2.8 CCC1=CC2=C(C=C1)N(C3=C(C=CC=N3)NC2=O)C(=O)CN4CCCCC4CN(CC)CC
CHEMBL48980 acm3_rat Rat No 5.7 IC50 = 2000 Funct
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligand
408 6 1 5 1.6 CCN(CC)CC1CCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL294919 acm3_rat Rat No 5.7 IC50 = 2000 Funct
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesInhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates
436 6 1 5 2.3 CCN(CC)CC1CCCCN1CC(=O)N2C3=C(C=CC(=C3)C)C(=O)NC4=C2N=CC=C4
CHEMBL50176 acm3_rat Rat No 5.7 IC50 = 2000 Funct
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesInhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates
450 7 1 5 2.8 CCC1=CC2=C(C=C1)N(C3=C(C=CC=N3)NC2=O)C(=O)CN4CCCCC4CN(CC)CC
CHEMBL48980 acm3_rat Rat No 5.7 IC50 = 2000 Funct
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesInhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates
408 6 1 5 1.6 CCN(CC)CC1CCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL121059 acm3_human Human No 6.7 IC50 = 201.6 Funct
Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M3 using membranes from transfected CHO cellsDisplacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M3 using membranes from transfected CHO cells
358 12 0 3 6.0 CCCCCCCCCOC(=O)C1=C(CCN(C1)CC)C2=CC=CC=C2
CHEMBL3084639 acm3_human Human No 6.7 IC50 = 206 Funct
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
382 5 0 1 7.3 CN1C2CCC1CC(C2)CC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL3084639 acm3_human Human No 6.7 IC50 = 206 Funct
Antagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
382 5 0 1 7.3 CN1C2CCC1CC(C2)CC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL71 acm3_human Human Yes 6.7 IC50 = 206 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
319 4 0 3 5.2 CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
CHEMBL3084639 acm3_human Human No 6.7 IC50 = 206 Funct
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
382 5 0 1 7.3 CN1C2CCC1CC(C2)CC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL3084639 acm3_human Human No 6.7 IC50 = 206 Funct
Antagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
382 5 0 1 7.3 CN1C2CCC1CC(C2)CC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL71 acm3_human Human Yes 6.7 IC50 = 206 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
319 4 0 3 5.2 CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
CHEMBL954 acm3_human Human Yes 5.7 IC50 = 2071 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
406 9 0 2 7.2 CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3
CHEMBL954 acm3_human Human Yes 5.7 IC50 = 2071 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
406 9 0 2 7.2 CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3
CHEMBL3085084 acm3_human Human No 5.7 IC50 = 2135.4 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
380 6 0 4 4.4 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC(=CC=C3)OC)C4=CC=CC=C4
CHEMBL3085084 acm3_human Human No 5.7 IC50 = 2135.4 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
380 6 0 4 4.4 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC(=CC=C3)OC)C4=CC=CC=C4
CHEMBL1779039 acm3_human Human No 7.7 IC50 = 22.5 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
356 6 0 4 3.5 C1CN2CCC1C(C2)OC(=O)N(CC3=CC=CC=C3)CC4=CC=CS4
CHEMBL1779039 acm3_human Human No 7.7 IC50 = 22.5 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
356 6 0 4 3.5 C1CN2CCC1C(C2)OC(=O)N(CC3=CC=CC=C3)CC4=CC=CS4
CHEMBL3085089 acm3_human Human No 7.6 IC50 = 22.9 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
356 5 0 4 4.4 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=CC=C3)C4=CC=CS4
CHEMBL3085089 acm3_human Human No 7.6 IC50 = 22.9 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
356 5 0 4 4.4 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=CC=C3)C4=CC=CS4
CHEMBL132698 acm3_human Human No 5.7 IC50 = 2200 Funct
In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M3In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M3
154 2 0 3 0.5 CON=CC1CN2CCC1C2
CHEMBL2206604 acm3_human Human No 6.7 IC50 = 223.2 Funct
Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
610 15 4 5 5.5 CC[N+](CC)(CCNC(=O)C(CC1=CC=C(C=C1)O)NC(=O)NC2=CC=C(C=C2)C(=O)OC(C)C)CC3=CC=C(C=C3)Cl
CHEMBL3085081 acm3_human Human No 5.6 IC50 = 2310.7 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
429 5 0 3 5.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC(=CC=C3)Br)C4=CC=CC=C4
CHEMBL3085081 acm3_human Human No 5.6 IC50 = 2310.7 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
429 5 0 3 5.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC(=CC=C3)Br)C4=CC=CC=C4
CHEMBL2206610 acm3_human Human No 6.6 IC50 = 237 Funct
Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
528 13 4 5 4.2 CC(C)[N+](C)(CCNC(=O)C(CC1=CC=C(C=C1)O)NC(=O)NC2=CC=C(C=C2)C(=O)OC(C)C)C(C)C
CHEMBL271704 acm3_rat Rat No 4.6 IC50 = 24000 Funct
Antagonist activity at rat muscarinic M3 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M3 receptor expressed in CHO cells by calcium mobilization assay
384 5 1 3 3.9 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3CC3C4=CC=CC=C4)Cl
CHEMBL271704 acm3_rat Rat No 4.6 IC50 = 24000 Funct
Antagonist activity at rat muscarinic M3 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M3 receptor expressed in CHO cells by calcium mobilization assay
384 5 1 3 3.9 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3CC3C4=CC=CC=C4)Cl
CHEMBL936 acm3_human Human Yes 6.6 IC50 = 245 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
309 6 1 2 4.2 C1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O
CHEMBL936 acm3_human Human Yes 6.6 IC50 = 245 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
309 6 1 2 4.2 C1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O
CHEMBL471214 acm3_human Human No 7.6 IC50 = 25.1 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
495 11 4 6 3.1 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4CC4
CHEMBL479526 acm3_human Human No 7.6 IC50 = 25.1 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
533 10 5 7 3.1 COC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL517087 acm3_human Human No 7.6 IC50 = 25.1 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
561 12 4 7 3.8 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC(=CC=C4)OC
CHEMBL471214 acm3_human Human No 7.6 IC50 = 25.1 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
495 11 4 6 3.1 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4CC4
CHEMBL479526 acm3_human Human No 7.6 IC50 = 25.1 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
533 10 5 7 3.1 COC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL517087 acm3_human Human No 7.6 IC50 = 25.1 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
561 12 4 7 3.8 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC(=CC=C4)OC
CHEMBL3087956 acm3_human Human No 7.6 IC50 = 25.1 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
490 7 0 4 6.6 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC5=CSC(=N5)C6=CC=CC=C6
CHEMBL494410 acm3_human Human No 6.6 IC50 = 251.2 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
400 6 2 3 3.9 CC1=CC=CC(=C1)C(=O)NCC2=CC=CC(=C2)C3=CC(=CC=C3)CN4CCNCC4
CHEMBL494778 acm3_human Human No 6.6 IC50 = 251.2 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
466 7 2 7 3.0 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNS(=O)(=O)C4=CC5=C(C=C4)OCO5
CHEMBL493939 acm3_human Human No 6.6 IC50 = 251.2 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
448 6 2 6 3.4 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=C(C=C3)F)CNC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL457302 acm3_human Human No 6.6 IC50 = 251.2 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
575 12 5 7 4.5 CC(C)COC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL1290635 acm3_human Human No 6.6 IC50 = 251.2 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
385 3 0 3 3.5 C1CN(CCC12CN(CCO2)C(=O)C3=CC=CC=C3)CC4=CC=C(C=C4)Cl
CHEMBL1924043 acm3_human Human No 6.6 IC50 = 251.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
414 8 0 3 5.4 CCC(CC)[N+]12CCC(CC1)C(C2)OC(=O)C(C)(C3=CC=CC=C3)N4CCCCC4
CHEMBL1083723 acm3_human Human No 6.6 IC50 = 251.2 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
343 4 2 2 4.1 CC1=C(C=C(C=C1)C2=CC=CC=C2C(=O)NCC3CCNCC3)Cl
CHEMBL494410 acm3_human Human No 6.6 IC50 = 251.2 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
400 6 2 3 3.9 CC1=CC=CC(=C1)C(=O)NCC2=CC=CC(=C2)C3=CC(=CC=C3)CN4CCNCC4
CHEMBL494778 acm3_human Human No 6.6 IC50 = 251.2 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
466 7 2 7 3.0 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNS(=O)(=O)C4=CC5=C(C=C4)OCO5
CHEMBL493939 acm3_human Human No 6.6 IC50 = 251.2 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
448 6 2 6 3.4 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=C(C=C3)F)CNC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL457302 acm3_human Human No 6.6 IC50 = 251.2 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
575 12 5 7 4.5 CC(C)COC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL1290635 acm3_human Human No 6.6 IC50 = 251.2 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
385 3 0 3 3.5 C1CN(CCC12CN(CCO2)C(=O)C3=CC=CC=C3)CC4=CC=C(C=C4)Cl
CHEMBL1924043 acm3_human Human No 6.6 IC50 = 251.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
414 8 0 3 5.4 CCC(CC)[N+]12CCC(CC1)C(C2)OC(=O)C(C)(C3=CC=CC=C3)N4CCCCC4
CHEMBL1083723 acm3_human Human No 6.6 IC50 = 251.2 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
343 4 2 2 4.1 CC1=C(C=C(C=C1)C2=CC=CC=C2C(=O)NCC3CCNCC3)Cl
CHEMBL524031 acm3_human Human No 5.6 IC50 = 2511.9 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
448 6 2 6 3.4 C1CN(CCN1)CC2=CC=CC(=C2)C3=C(C(=CC=C3)CNC(=O)C4=CC5=C(C=C4)OCO5)F
CHEMBL519893 acm3_human Human No 5.6 IC50 = 2511.9 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
541 9 5 6 2.6 CNC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)C#N
CHEMBL1083926 acm3_human Human No 5.6 IC50 = 2511.9 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
361 4 2 3 4.3 CC1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL524031 acm3_human Human No 5.6 IC50 = 2511.9 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
448 6 2 6 3.4 C1CN(CCN1)CC2=CC=CC(=C2)C3=C(C(=CC=C3)CNC(=O)C4=CC5=C(C=C4)OCO5)F
CHEMBL519893 acm3_human Human No 5.6 IC50 = 2511.9 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
541 9 5 6 2.6 CNC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)C#N
CHEMBL1083926 acm3_human Human No 5.6 IC50 = 2511.9 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
361 4 2 3 4.3 CC1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL120135 acm3_human Human No 5.6 IC50 = 2551.1 Funct
Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M3 using membranes from transfected CHO cellsDisplacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M3 using membranes from transfected CHO cells
315 5 0 3 4.2 CCN1CCC(C(C1)C(=O)OC2CCCCC2)C3=CC=CC=C3
CHEMBL2023761 acm3_human Human No 7.6 IC50 = 26.3 Funct
Antagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysisAntagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis
386 6 0 1 5.6 C[N+]1(C2CCC1CC(C2)CC(C#N)(C3=CC=CC=C3)C4=CC=CC=C4)CC5CC5
CHEMBL2023761 acm3_human Human No 7.6 IC50 = 26.3 Funct
Antagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysisAntagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis
386 6 0 1 5.6 C[N+]1(C2CCC1CC(C2)CC(C#N)(C3=CC=CC=C3)C4=CC=CC=C4)CC5CC5
CHEMBL3085085 acm3_human Human No 6.6 IC50 = 261.6 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
371 5 0 4 4.5 CC1=CC=C(S1)CN(C2=CC=CC=C2)C(=O)OC3CC4CCC(C3)N4C
CHEMBL3085085 acm3_human Human No 6.6 IC50 = 261.6 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
371 5 0 4 4.5 CC1=CC=C(S1)CN(C2=CC=CC=C2)C(=O)OC3CC4CCC(C3)N4C
CHEMBL62247 acm3_human Human No 5.6 IC50 = 2629 Funct
Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
406 5 1 5 4.2 CCOC1=CC2=C(C=C1)C3N(CC2)CC4=C(O3)C=CC5=C4C(=C(N5)C)C(=O)OCC
CHEMBL3085078 acm3_human Human No 7.6 IC50 = 27.5 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
356 5 0 4 4.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CSC=C3)C4=CC=CC=C4
CHEMBL3085078 acm3_human Human No 7.6 IC50 = 27.5 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
356 5 0 4 4.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CSC=C3)C4=CC=CC=C4
CHEMBL2206589 acm3_human Human No 7.6 IC50 = 27.5 Funct
Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
622 11 3 5 5.5 CC(C)[N+]1(CCN(CC1)C(=O)C(CC2=CC=C(C=C2)O)NC(=O)NC3=CC=C(C=C3)C(=O)OC(C)C)CC4=CC=C(C=C4)Cl
CHEMBL303758 acm3_human Human No 5.6 IC50 = 2720.9 Funct
Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
376 3 1 4 4.3 CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=C(C=C5)C)C
CHEMBL3084670 acm3_human Human No 5.6 IC50 = 2732 Funct
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
413 7 1 4 4.5 CN1C2CCC1CC(C2)CC(CNS(=O)(=O)C)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL3084670 acm3_human Human No 5.6 IC50 = 2732 Funct
Antagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
413 7 1 4 4.5 CN1C2CCC1CC(C2)CC(CNS(=O)(=O)C)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL3084670 acm3_human Human No 5.6 IC50 = 2732 Funct
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
413 7 1 4 4.5 CN1C2CCC1CC(C2)CC(CNS(=O)(=O)C)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL3084670 acm3_human Human No 5.6 IC50 = 2732 Funct
Antagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
413 7 1 4 4.5 CN1C2CCC1CC(C2)CC(CNS(=O)(=O)C)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL135645 acm3_human Human No 7.6 IC50 = 28 Funct
In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB)radioligand in human cloned Muscarinic acetylcholine receptor M3In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB)radioligand in human cloned Muscarinic acetylcholine receptor M3
193 2 0 4 0.9 CON=C(C#N)C12CCCN(C1)CC2
CHEMBL62251 acm3_human Human No 5.6 IC50 = 2817 Funct
Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
406 4 1 5 4.3 CC1=C(C2=C(N1)C=CC3=C2CN4CCC5=C(C4O3)C=CC(=C5)OC)C(=O)OC(C)C
CHEMBL304036 acm3_human Human No 5.6 IC50 = 2827.7 Funct
Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
376 3 1 4 4.3 CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=CC=C5C)C
CHEMBL3084674 acm3_human Human No 5.5 IC50 = 2895 Funct
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
377 6 1 2 4.7 CC(=O)NCC(CC1CC2CCC(C1)N2C)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL3084674 acm3_human Human No 5.5 IC50 = 2895 Funct
Antagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
377 6 1 2 4.7 CC(=O)NCC(CC1CC2CCC(C1)N2C)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL3084674 acm3_human Human No 5.5 IC50 = 2895 Funct
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
377 6 1 2 4.7 CC(=O)NCC(CC1CC2CCC(C1)N2C)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL3084674 acm3_human Human No 5.5 IC50 = 2895 Funct
Antagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
377 6 1 2 4.7 CC(=O)NCC(CC1CC2CCC(C1)N2C)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL83 acm3_human Human Yes 5.5 IC50 = 2974 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
372 8 0 2 7.1 CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
CHEMBL1921930 acm3_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
482 9 0 5 5.3 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCOC4=CC=C(C=C4)F)N5CCCCC5
CHEMBL1924041 acm3_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
478 10 0 4 5.6 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCCOC4=CC=CC=C4)N5CCCCC5
CHEMBL1921923 acm3_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
464 9 0 5 4.1 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCCC4=CN=CN=C4)N5CCCCC5
CHEMBL1921802 acm3_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
449 8 0 4 4.4 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCC4=CN=CC=C4)N5CCCCC5
CHEMBL1924028 acm3_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
331 5 0 3 3.2 CC(C1=CC=CC=C1)(C(=O)OC2CC[N+](CC2)(C)C)N3CCCC3
CHEMBL1921930 acm3_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
482 9 0 5 5.3 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCOC4=CC=C(C=C4)F)N5CCCCC5
CHEMBL1924041 acm3_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
478 10 0 4 5.6 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCCOC4=CC=CC=C4)N5CCCCC5
CHEMBL1921923 acm3_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
464 9 0 5 4.1 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCCC4=CN=CN=C4)N5CCCCC5
CHEMBL1921802 acm3_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
449 8 0 4 4.4 CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCC4=CN=CC=C4)N5CCCCC5
CHEMBL1924028 acm3_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
331 5 0 3 3.2 CC(C1=CC=CC=C1)(C(=O)OC2CC[N+](CC2)(C)C)N3CCCC3
CHEMBL3088079 acm3_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
437 7 0 3 5.8 COC1=CC=CC(=C1)C[N+]23CCC(CC2)C(C3)OC(=O)C4(CCCCCC4)C5=CC=CC5
CHEMBL3087950 acm3_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
523 10 2 6 2.9 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)NCCNC(=O)C5=NC=CN=C5
CHEMBL3088083 acm3_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
446 7 0 3 6.0 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CCC5=CC=C(C=C5)C#N
CHEMBL1779032 acm3_human Human No 8.4 IC50 = 3.6 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
350 6 0 3 4.3 C1CN2CCC1C(C2)OC(=O)N(CCC3=CC=CC=C3)C4=CC=CC=C4
CHEMBL1779032 acm3_human Human No 8.4 IC50 = 3.6 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
350 6 0 3 4.3 C1CN2CCC1C(C2)OC(=O)N(CCC3=CC=CC=C3)C4=CC=CC=C4
CHEMBL495028 acm3_human Human No 8.4 IC50 = 4.0 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
498 8 2 5 3.1 CN1CCN(CC1)CC2=CC=CC(=C2)C(=O)NCC3=CC=CC(=C3)C4=CC(=CC=C4)CN5CCNCC5
CHEMBL495028 acm3_human Human No 8.4 IC50 = 4.0 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
498 8 2 5 3.1 CN1CCN(CC1)CC2=CC=CC(=C2)C(=O)NCC3=CC=CC(=C3)C4=CC(=CC=C4)CN5CCNCC5
CHEMBL1289866 acm3_human Human No 8.4 IC50 = 4.0 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
400 4 0 5 3.4 CC(C)C1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=CC=C4
CHEMBL1289866 acm3_human Human No 8.4 IC50 = 4.0 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
400 4 0 5 3.4 CC(C)C1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=CC=C4
CHEMBL1770373 acm3_human Human Yes 6.5 IC50 = 300 Funct
Binding affinity to muscarinic M3 receptorBinding affinity to muscarinic M3 receptor
239 2 1 3 2.1 C1CNCCC2=NC(=NC=C21)CC3=CC=CC=C3
CHEMBL295214 acm3_rat Rat No 6.5 IC50 = 300 Funct
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligand
422 6 1 5 1.8 CCN(CC)CC1CCCN(C1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL1770373 acm3_human Human Yes 6.5 IC50 = 300 Funct
Binding affinity to muscarinic M3 receptorBinding affinity to muscarinic M3 receptor
239 2 1 3 2.1 C1CNCCC2=NC(=NC=C21)CC3=CC=CC=C3
CHEMBL9967 acm3_rat Rat Yes 6.5 IC50 = 300 Funct
Displacement of [3H]methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.Displacement of [3H]methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.
351 2 1 5 0.1 CN1CCN(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL344892 acm3_human Human No 6.5 IC50 = 300 Funct
In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M3In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M3
179 2 0 4 0.5 CON=C(C#N)C12CCN(C1)CC2
CHEMBL295214 acm3_rat Rat No 6.5 IC50 = 300 Funct
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesInhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates
422 6 1 5 1.8 CCN(CC)CC1CCCN(C1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL498556 acm3_human Human No 5.5 IC50 = 3000 Funct
Binding affinity to human muscarinic M3 receptorBinding affinity to human muscarinic M3 receptor
455 4 0 2 4.9 CC(=O)N1CCCC(C1)(C2CCN(CC2)CC3=CC=C(C=C3)Br)C4=CC=CC=C4
CHEMBL296365 acm3_rat Rat No 5.5 IC50 = 3000 Funct
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligand
393 5 2 5 1.1 CCNCC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL498556 acm3_human Human No 5.5 IC50 = 3000 Funct
Binding affinity to human muscarinic M3 receptorBinding affinity to human muscarinic M3 receptor
455 4 0 2 4.9 CC(=O)N1CCCC(C1)(C2CCN(CC2)CC3=CC=C(C=C3)Br)C4=CC=CC=C4
CHEMBL296365 acm3_rat Rat No 5.5 IC50 = 3000 Funct
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesInhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates
393 5 2 5 1.1 CCNCC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL61700 acm3_human Human No 5.5 IC50 = 3067.8 Funct
Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
455 5 1 5 5.4 CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=C(C=C5)OC6=CC=CC=C6)C
CHEMBL493079 acm3_human Human No 7.5 IC50 = 31.6 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
430 6 2 5 3.3 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL522838 acm3_human Human No 7.5 IC50 = 31.6 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
460 7 2 6 3.3 COC1=C(C=C(C=C1)CNC(=O)C2=CC3=C(C=C2)OCO3)C4=CC(=CC=C4)CN5CCNCC5
CHEMBL501419 acm3_human Human No 7.5 IC50 = 31.6 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
575 11 4 8 3.7 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC5=C(C=C4)OCO5
CHEMBL1290752 acm3_human Human No 7.5 IC50 = 31.6 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
425 3 0 4 3.9 C1CN(CCC12CN(CCO2)C(=O)C3=CC4=C(C=C3)OC=C4)CC5=CC=C(C=C5)Cl
CHEMBL493079 acm3_human Human No 7.5 IC50 = 31.6 Funct
Inhibition of human cloned muscarinic M3 receptor expressed in CHO cells by FLIPR assayInhibition of human cloned muscarinic M3 receptor expressed in CHO cells by FLIPR assay
430 6 2 5 3.3 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL493079 acm3_human Human No 7.5 IC50 = 31.6 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
430 6 2 5 3.3 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL522838 acm3_human Human No 7.5 IC50 = 31.6 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
460 7 2 6 3.3 COC1=C(C=C(C=C1)CNC(=O)C2=CC3=C(C=C2)OCO3)C4=CC(=CC=C4)CN5CCNCC5
CHEMBL501419 acm3_human Human No 7.5 IC50 = 31.6 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
575 11 4 8 3.7 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC5=C(C=C4)OCO5
CHEMBL1290752 acm3_human Human No 7.5 IC50 = 31.6 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
425 3 0 4 3.9 C1CN(CCC12CN(CCO2)C(=O)C3=CC4=C(C=C3)OC=C4)CC5=CC=C(C=C5)Cl
CHEMBL3087363 acm3_human Human No 7.5 IC50 = 31.6 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
451 7 1 4 4.5 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC(=O)NC5=CC=CC=N5
CHEMBL493079 acm3_human Human No 7.5 IC50 = 31.6 Funct
Inhibition of human cloned muscarinic M3 receptor expressed in CHO cells by FLIPR assayInhibition of human cloned muscarinic M3 receptor expressed in CHO cells by FLIPR assay
430 6 2 5 3.3 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL255523 acm3_rat Rat No 5.5 IC50 = 3100 Funct
Antagonist activity at rat muscarinic M3 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M3 receptor expressed in CHO cells by calcium mobilization assay
364 6 1 3 4.5 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)CCC3CCCC3)Cl
CHEMBL255523 acm3_rat Rat No 5.5 IC50 = 3100 Funct
Antagonist activity at rat muscarinic M3 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M3 receptor expressed in CHO cells by calcium mobilization assay
364 6 1 3 4.5 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)CCC3CCCC3)Cl
CHEMBL75880 acm3_human Human Yes 5.5 IC50 = 3118.6 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
277 4 1 1 6.8 C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3
CHEMBL75880 acm3_human Human Yes 5.5 IC50 = 3118.6 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
277 4 1 1 6.8 C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3
CHEMBL91 acm3_human Human Yes 5.5 IC50 = 3154 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
416 6 0 2 5.3 C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl
CHEMBL91 acm3_human Human Yes 5.5 IC50 = 3154 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
416 6 0 2 5.3 C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl
CHEMBL492998 acm3_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
420 6 2 3 4.1 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC=C(C=C4)Cl
CHEMBL494411 acm3_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
414 7 2 3 4.3 CCC1=CC=CC(=C1)C(=O)NCC2=CC=CC(=C2)C3=CC(=CC=C3)CN4CCNCC4
CHEMBL495025 acm3_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
411 6 2 4 3.2 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC=CC=C4C#N
CHEMBL492756 acm3_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
460 7 2 6 3.3 COC1=C(C=C(C=C1)C2=CC(=CC=C2)CNC(=O)C3=CC4=C(C=C3)OCO4)CN5CCNCC5
CHEMBL494836 acm3_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
444 6 2 5 3.7 C1CNCCN(C1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL487764 acm3_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
555 10 5 6 3.0 CCNC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)C#N
CHEMBL1290410 acm3_human Human No 6.5 IC50 = 316.2 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
355 3 0 3 3.7 C1CN(CCC12CCN(CC2)C(=O)C3=CSC=C3)CC4=CC=CC=C4
CHEMBL492998 acm3_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
420 6 2 3 4.1 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC=C(C=C4)Cl
CHEMBL494411 acm3_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
414 7 2 3 4.3 CCC1=CC=CC(=C1)C(=O)NCC2=CC=CC(=C2)C3=CC(=CC=C3)CN4CCNCC4
CHEMBL495025 acm3_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
411 6 2 4 3.2 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC=CC=C4C#N
CHEMBL492756 acm3_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
460 7 2 6 3.3 COC1=C(C=C(C=C1)C2=CC(=CC=C2)CNC(=O)C3=CC4=C(C=C3)OCO4)CN5CCNCC5
CHEMBL494836 acm3_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
444 6 2 5 3.7 C1CNCCN(C1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL487764 acm3_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
555 10 5 6 3.0 CCNC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)C#N
CHEMBL1290410 acm3_human Human No 6.5 IC50 = 316.2 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
355 3 0 3 3.7 C1CN(CCC12CCN(CC2)C(=O)C3=CSC=C3)CC4=CC=CC=C4
CHEMBL505453 acm3_human Human No 5.5 IC50 = 3162.3 Funct
Antagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL244946 acm3_human Human Yes 5.5 IC50 = 3162.3 Funct
Antagonist activity at human muscarinic receptor M3Antagonist activity at human muscarinic receptor M3
538 7 0 6 5.4 CC1=NC2=CC=CC(=C2C=C1)C3=NN=C(N3C)SCCCN4CCC5=C(CC4)C=C(C=C5)C6=CC(=NN6C)C
CHEMBL494131 acm3_human Human No 5.5 IC50 = 3162.3 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
444 6 2 5 3.7 CC1=C(C=C(C=C1)C2=CC(=CC=C2)CN3CCNCC3)CNC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL1083618 acm3_human Human No 5.5 IC50 = 3162.3 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
345 4 2 3 3.2 C1CNCC=C1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL505453 acm3_human Human No 5.5 IC50 = 3162.3 Funct
Antagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL244946 acm3_human Human Yes 5.5 IC50 = 3162.3 Funct
Antagonist activity at human muscarinic receptor M3Antagonist activity at human muscarinic receptor M3
538 7 0 6 5.4 CC1=NC2=CC=CC(=C2C=C1)C3=NN=C(N3C)SCCCN4CCC5=C(CC4)C=C(C=C5)C6=CC(=NN6C)C
CHEMBL494131 acm3_human Human No 5.5 IC50 = 3162.3 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
444 6 2 5 3.7 CC1=C(C=C(C=C1)C2=CC(=CC=C2)CN3CCNCC3)CNC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL1083618 acm3_human Human No 5.5 IC50 = 3162.3 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
345 4 2 3 3.2 C1CNCC=C1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL2023763 acm3_human Human No 7.5 IC50 = 32 Funct
Antagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysisAntagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis
414 9 0 1 6.7 C[N+]1(C2CCC1CC(C2)CC(C#N)(C3=CC=CC=C3)C4=CC=CC=C4)CCCCC=C
CHEMBL2023763 acm3_human Human No 7.5 IC50 = 32 Funct
Antagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysisAntagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis
414 9 0 1 6.7 C[N+]1(C2CCC1CC(C2)CC(C#N)(C3=CC=CC=C3)C4=CC=CC=C4)CCCCC=C
CHEMBL633 acm3_human Human Yes 5.5 IC50 = 3201 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
645 11 0 4 7.6 CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I
CHEMBL633 acm3_human Human Yes 5.5 IC50 = 3201 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
645 11 0 4 7.6 CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I
CHEMBL59347 acm3_human Human No 4.5 IC50 = 32589.6 Funct
Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
350 2 1 4 3.6 CC1=CC2=C(N1)C=CC3=C2CN4CCC5=CC(=C(C=C5C4O3)OC)OC
CHEMBL2206608 acm3_human Human No 7.5 IC50 = 33.4 Funct
Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
622 13 4 5 5.6 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NCC[N+]3(CCCCC3)CC4=CC=C(C=C4)Cl
CHEMBL59939 acm3_human Human No 5.5 IC50 = 3394 Funct
Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
378 3 1 5 3.5 CC1=C(C2=C(N1)C=CC3=C2CN4CCC5=C(C4O3)C=CC(=C5)OC)C(=O)OC
CHEMBL1221 acm3_human Human Yes 5.5 IC50 = 3404 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
398 6 0 2 6.1 C1=CC(=CC=C1CSC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
CHEMBL1221 acm3_human Human Yes 5.5 IC50 = 3404 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
398 6 0 2 6.1 C1=CC(=CC=C1CSC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
CHEMBL2111621 acm3_rat Rat No 5.5 IC50 = 3500 Funct
Displacement of [3H]methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.Displacement of [3H]methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.
390 2 1 4 1.8 C1CCN2CCCC(C2C1)CC(=O)N3C4=CC=CC=C4C(=O)NC5=C3N=CC=C5
CHEMBL41 acm3_human Human Yes 5.4 IC50 = 3595 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
309 6 1 5 4.0 CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F
CHEMBL41 acm3_human Human Yes 5.4 IC50 = 3595 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
309 6 1 5 4.0 CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F
CHEMBL3670827 acm3_human Human No 7.4 IC50 = 36 Funct
Radioligand Binding Assay: Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). Incubations of test ligands (or standard) with 0.2 nM [3H]4-DAMP were incubated for 120 minutes at 22 C. using human M3 receptor-expressing cell homogenates. Specific ligand binding to the receptors was defined as the difference between the total radioligand binding and the nonspecific binding determined in the presence of an excess of unlabelled ligand (10 atropine). The results were expressed as a percent of control specific binding ((measured specific binding/control specific binding)x100) obtained in the presence of various concentrations of the test compounds.Radioligand Binding Assay: Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). Incubations of test ligands (or standard) with 0.2 nM [3H]4-DAMP were incubated for 120 minutes at 22 C. using human M3 receptor-expressing cell homogenates. Specific ligand binding to the receptors was defined as the difference between the total radioligand binding and the nonspecific binding determined in the presence of an excess of unlabelled ligand (10 atropine). The results were expressed as a percent of control specific binding ((measured specific binding/control specific binding)x100) obtained in the presence of various concentrations of the test compounds.
344 5 1 3 3.7 C[N+]1(C2CCC1C(C2)OC(=O)C(C3CCCC3)(C4=CC=CC=C4)O)C
CHEMBL3401646 acm3_human Human No 7.4 IC50 = 37.3 Funct
Displacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
334 2 1 3 2.6 C1CN2CCC1C(C2)NC(=O)C3C4=CC=CC=C4OC5=CC=CC=C35
CHEMBL3401646 acm3_human Human No 7.4 IC50 = 37.3 Funct
Displacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
334 2 1 3 2.6 C1CN2CCC1C(C2)NC(=O)C3C4=CC=CC=C4OC5=CC=CC=C35
CHEMBL1090094 acm3_human Human No 5.4 IC50 = 3700 Funct
Antagonist activity at human muscarinic M3 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M3 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization
434 4 1 8 4.2 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=C(C(=C(C(=C3F)F)F)F)F)Cl
CHEMBL1090094 acm3_human Human No 5.4 IC50 = 3700 Funct
Antagonist activity at human muscarinic M3 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M3 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization
434 4 1 8 4.2 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=C(C(=C(C(=C3F)F)F)F)F)Cl
CHEMBL60142 acm3_human Human No 5.4 IC50 = 3704.2 Funct
Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
378 4 1 5 3.5 CCOC(=O)C1=CNC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=C(C=C5)OC
CHEMBL137384 acm3_human Human No 6.4 IC50 = 380 Funct
In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M3In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M3
179 2 0 4 0.6 CON=C(C#N)C1CN2CCC1C2
CHEMBL1626 acm3_human Human Yes 7.4 IC50 = 39 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
344 6 0 2 5.0 CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCC3CCCN3C
CHEMBL1626 acm3_human Human Yes 7.4 IC50 = 39 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
344 6 0 2 5.0 CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCC3CCCN3C
CHEMBL492701 acm3_human Human No 7.4 IC50 = 39.8 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
445 6 2 6 2.7 CC1CN(CCN1)CC2=CC=CC(=N2)C3=CC(=CC=C3)CNC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL1083925 acm3_human Human No 7.4 IC50 = 39.8 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
361 4 2 3 4.3 CC1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL492701 acm3_human Human No 7.4 IC50 = 39.8 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
445 6 2 6 2.7 CC1CN(CCN1)CC2=CC=CC(=N2)C3=CC(=CC=C3)CNC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL3088077 acm3_human Human No 7.4 IC50 = 39.8 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
407 6 0 2 5.9 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC5=CC=CC=C5
CHEMBL3088078 acm3_human Human No 7.4 IC50 = 39.8 Funct
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA methodDisplacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method
443 6 0 4 6.1 C1CCCC(CC1)(C2=CC=CC2)C(=O)OC3C[N+]4(CCC3CC4)CC5=CC(=C(C=C5)F)F
CHEMBL1083925 acm3_human Human No 7.4 IC50 = 39.8 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
361 4 2 3 4.3 CC1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL715 acm3_human Human Yes 6.4 IC50 = 392 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
312 1 1 5 2.8 CC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCN(CC4)C
CHEMBL715 acm3_human Human Yes 6.4 IC50 = 392 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
312 1 1 5 2.8 CC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCN(CC4)C
CHEMBL2206594 acm3_human Human No 6.4 IC50 = 392.4 Funct
Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
619 12 3 5 4.7 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)N(C)CC3=[N+](C=CN3CC4=CC=C(C=C4)Cl)C
CHEMBL450093 acm3_human Human No 6.4 IC50 = 398.1 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
583 11 4 6 3.5 CCN(CC)C(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)C#N
CHEMBL1289432 acm3_human Human No 6.4 IC50 = 398.1 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
376 3 0 5 2.3 C1CN(CCC12CN(CCO2)C(=O)C3=NOC=C3)CC4=CC=C(C=C4)Cl
CHEMBL1290077 acm3_human Human No 6.4 IC50 = 398.1 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
414 4 0 5 3.8 CC1=CC=CC=C1CN2CCC3(CC2)CN(CCO3)C(=O)C4=CSC(=N4)C(C)C
CHEMBL1289315 acm3_human Human No 6.4 IC50 = 398.1 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
387 3 0 5 2.2 C1CN(CCC12CN(CCO2)C(=O)C3=NC=CC=N3)CC4=CC=C(C=C4)Cl
CHEMBL450093 acm3_human Human No 6.4 IC50 = 398.1 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
583 11 4 6 3.5 CCN(CC)C(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)C#N
CHEMBL1289432 acm3_human Human No 6.4 IC50 = 398.1 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
376 3 0 5 2.3 C1CN(CCC12CN(CCO2)C(=O)C3=NOC=C3)CC4=CC=C(C=C4)Cl
CHEMBL1290077 acm3_human Human No 6.4 IC50 = 398.1 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
414 4 0 5 3.8 CC1=CC=CC=C1CN2CCC3(CC2)CN(CCO3)C(=O)C4=CSC(=N4)C(C)C
CHEMBL1289315 acm3_human Human No 6.4 IC50 = 398.1 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
387 3 0 5 2.2 C1CN(CCC12CN(CCO2)C(=O)C3=NC=CC=N3)CC4=CC=C(C=C4)Cl
CHEMBL494151 acm3_human Human No 5.4 IC50 = 3981.1 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
454 6 2 6 4.4 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC=CC=C4C(F)(F)F
CHEMBL523012 acm3_human Human No 5.4 IC50 = 3981.1 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
472 6 1 5 3.2 CC(=O)N1CCN(CC1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL1085507 acm3_human Human No 5.4 IC50 = 3981.1 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
329 4 2 2 3.8 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL1083403 acm3_human Human No 5.4 IC50 = 3981.1 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
392 3 1 5 4.9 C1CNCCC1C2=NOC(=N2)C3=C(C=CC=C3F)C4=C(C=CC(=C4)Cl)Cl
CHEMBL494151 acm3_human Human No 5.4 IC50 = 3981.1 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
454 6 2 6 4.4 C1CN(CCN1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC=CC=C4C(F)(F)F
CHEMBL523012 acm3_human Human No 5.4 IC50 = 3981.1 Funct
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
472 6 1 5 3.2 CC(=O)N1CCN(CC1)CC2=CC=CC(=C2)C3=CC(=CC=C3)CNC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL1085507 acm3_human Human No 5.4 IC50 = 3981.1 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
329 4 2 2 3.8 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL1083403 acm3_human Human No 5.4 IC50 = 3981.1 Funct
Inhibition of human muscarinic M3 receptor expressed in CHO cellsInhibition of human muscarinic M3 receptor expressed in CHO cells
392 3 1 5 4.9 C1CNCCC1C2=NOC(=N2)C3=C(C=CC=C3F)C4=C(C=CC(=C4)Cl)Cl
CHEMBL332320 acm3_human Human No 6.4 IC50 = 399.5 Funct
Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M3 using membranes from transfected CHO cellsDisplacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M3 using membranes from transfected CHO cells
372 13 0 3 6.6 CCCCCCCCCCOC(=O)C1=C(CCN(C1)CC)C2=CC=CC=C2
CHEMBL1779036 acm3_human Human No 8.4 IC50 = 4.3 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
302 6 0 3 3.6 CCCCN(C1=CC=CC=C1)C(=O)OC2CN3CCC2CC3
CHEMBL1779036 acm3_human Human No 8.4 IC50 = 4.3 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
302 6 0 3 3.6 CCCCN(C1=CC=CC=C1)C(=O)OC2CN3CCC2CC3
CHEMBL1123 acm3_human Human Yes 8.4 IC50 = 4.4 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
309 8 0 3 5.5 CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2
CHEMBL1123 acm3_human Human Yes 8.4 IC50 = 4.4 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
309 8 0 3 5.5 CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2
CHEMBL299344 acm3_rat Rat Yes 5.4 IC50 = 4000 Funct
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligand
500 6 1 5 2.7 CCN(CC)CC1CCCCN1CC(=O)N2C3=C(C=C(C=C3)Br)C(=O)NC4=C2N=CC=C4
CHEMBL298078 acm3_rat Rat No 5.4 IC50 = 4000 Funct
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligand
422 6 1 5 1.8 CCN(CC)CC1CCN(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL432886 acm3_rat Rat No 5.4 IC50 = 4000 Funct
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligand
436 4 1 6 0.9 C1CCN(C(C1)CN2CCOCC2)CC(=O)N3C4=CC=CC=C4C(=O)NC5=C3N=CC=C5
CHEMBL49721 acm3_rat Rat No 5.4 IC50 = 4000 Funct
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]N-methylscopolamine as radioligand
456 6 1 5 2.6 CCN(CC)CC1CCCCN1CC(=O)N2C3=C(C=C(C=C3)Cl)C(=O)NC4=C2N=CC=C4
CHEMBL299344 acm3_rat Rat Yes 5.4 IC50 = 4000 Funct
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesInhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates
500 6 1 5 2.7 CCN(CC)CC1CCCCN1CC(=O)N2C3=C(C=C(C=C3)Br)C(=O)NC4=C2N=CC=C4
CHEMBL298078 acm3_rat Rat No 5.4 IC50 = 4000 Funct
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesInhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates
422 6 1 5 1.8 CCN(CC)CC1CCN(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL432886 acm3_rat Rat No 5.4 IC50 = 4000 Funct
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesInhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates
436 4 1 6 0.9 C1CCN(C(C1)CN2CCOCC2)CC(=O)N3C4=CC=CC=C4C(=O)NC5=C3N=CC=C5
CHEMBL49721 acm3_rat Rat No 5.4 IC50 = 4000 Funct
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesInhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates
456 6 1 5 2.6 CCN(CC)CC1CCCCN1CC(=O)N2C3=C(C=C(C=C3)Cl)C(=O)NC4=C2N=CC=C4
CHEMBL564 acm3_human Human Yes 6.4 IC50 = 416 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
284 4 0 3 4.5 CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31
CHEMBL564 acm3_human Human Yes 6.4 IC50 = 416 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
284 4 0 3 4.5 CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31
CHEMBL3633663 acm3_human Human No 5.4 IC50 = 4168.7 Funct
Antagonist activity at human muscarinic M3 receptor expressed in HEK293 cells assessed as inhibition of carbachol-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at human muscarinic M3 receptor expressed in HEK293 cells assessed as inhibition of carbachol-induced inositol monophosphate accumulation after 1 hr by FRET assay
432 5 1 4 3.0 C1CC(CN(C1)CC(=O)C2=C(NC3=CC=CC=C32)C4=CC=CC=C4)C(=O)N5CCOCC5
CHEMBL2207176 acm3_human Human No 6.4 IC50 = 417.1 Funct
Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
612 14 4 5 5.7 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NCCC[N+](C)(C)CC3=CC4=CC=CC=C4C=C3
CHEMBL3633656 acm3_human Human No 5.4 IC50 = 4170 Funct
Antagonist activity at human muscarinic M3 receptor expressed in HEK293 cells assessed as inhibition of carbachol-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at human muscarinic M3 receptor expressed in HEK293 cells assessed as inhibition of carbachol-induced inositol monophosphate accumulation after 1 hr by FRET assay
421 7 1 5 2.6 CN(CC(=O)C1=C(NC2=CC=CC=C21)C3=CC=C(C=C3)OC)CC(=O)N4CCOCC4
CHEMBL1090097 acm3_human Human No 5.4 IC50 = 4200 Funct
Antagonist activity at human muscarinic M3 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M3 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization
480 4 1 9 5.5 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=C(C=CC(=C3)C(F)(F)F)C(F)(F)F)Cl
CHEMBL1090097 acm3_human Human No 5.4 IC50 = 4200 Funct
Antagonist activity at human muscarinic M3 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M3 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization
480 4 1 9 5.5 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=C(C=CC(=C3)C(F)(F)F)C(F)(F)F)Cl
CHEMBL3085088 acm3_human Human No 6.4 IC50 = 428.3 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
354 5 0 4 3.9 CC1=C(OC=C1)CN(C2=CC=CC=C2)C(=O)OC3CC4CCC(C3)N4C
CHEMBL3085088 acm3_human Human No 6.4 IC50 = 428.3 Funct
Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization
354 5 0 4 3.9 CC1=C(OC=C1)CN(C2=CC=CC=C2)C(=O)OC3CC4CCC(C3)N4C
CHEMBL1090096 acm3_human Human No 5.4 IC50 = 4300 Funct
Antagonist activity at human muscarinic M3 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M3 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization
412 4 1 6 4.6 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=CC(=CC=C3)C(F)(F)F)Cl
CHEMBL1090096 acm3_human Human No 5.4 IC50 = 4300 Funct
Antagonist activity at human muscarinic M3 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M3 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization
412 4 1 6 4.6 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=CC(=CC=C3)C(F)(F)F)Cl
CHEMBL2206607 acm3_human Human No 7.4 IC50 = 44.9 Funct
Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
608 13 4 5 5.2 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NCC[N+]3(CCCC3)CC4=CC=C(C=C4)Cl
CHEMBL1172 acm3_human Human Yes 6.4 IC50 = 446 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
311 0 1 2 4.5 C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4
CHEMBL1172 acm3_human Human Yes 6.4 IC50 = 446 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
311 0 1 2 4.5 C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4
CHEMBL2206599 acm3_human Human No 7.3 IC50 = 45.3 Funct
Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
622 11 3 5 5.5 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)N3CCCC(C3)[N+](C)(C)CC4=CC=C(C=C4)Cl
CHEMBL2203713 acm3_human Human No 5.4 IC50 = 4500 Funct
Inhibition of muscarinic M3 receptorInhibition of muscarinic M3 receptor
326 3 2 4 2.9 C1CNCCC1N2CCC3=C2C=CC(=C3)N=C(C4=CC=CS4)N
CHEMBL1262 acm3_human Human Yes 5.3 IC50 = 4531 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
429 6 0 3 6.1 C1=CC(=C(C=C1Cl)Cl)CON=C(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl
CHEMBL510340 acm3_human Human Yes 5.3 IC50 = 4560 Funct
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in insect Sf9 cellsDisplacement of [3H]NMS from human muscarinic M3 receptor expressed in insect Sf9 cells
770 25 5 10 7.6 CCCCCCCCCCCCCC(C(C)C(=O)NC1CCCCNC1=O)OC(=O)C(CCCCN(C(=O)C)O)NC(=O)C2=COC(=C3C=CC=CC3=O)N2
CHEMBL588119 acm3_human Human Yes 5.3 IC50 = 4623.8 Funct
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)</