Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL3184840 apj_human Human Yes 10.9 EC50 = 0.0 Funct
Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assayAgonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assay
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3184840 apj_human Human Yes 10.9 EC50 = 0.0 Funct
Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assayAgonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assay
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417385 apj_human Human No 10.4 EC50 = 0.0 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1620 46 18 21 -3.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)C(=O)C3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3417385 apj_human Human No 10.4 EC50 = 0.0 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1620 46 18 21 -3.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)C(=O)C3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3417389 apj_human Human No 10.2 EC50 = 0.1 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1530 44 18 20 -5.0 CCCCC(C(=O)N1CCCC1C(=O)NC(C)(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417389 apj_human Human No 10.2 EC50 = 0.1 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1530 44 18 20 -5.0 CCCCC(C(=O)N1CCCC1C(=O)NC(C)(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417378 apj_human Human No 9.8 EC50 = 0.2 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1530 44 18 20 -4.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)C)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417378 apj_human Human No 9.8 EC50 = 0.2 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1530 44 18 20 -4.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)C)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417377 apj_human Human No 9.6 EC50 = 0.2 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1546 45 18 21 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OC)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417377 apj_human Human No 9.6 EC50 = 0.2 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1546 45 18 21 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OC)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417383 apj_human Human No 9.6 EC50 = 0.2 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1530 45 18 20 -4.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CCC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417383 apj_human Human No 9.6 EC50 = 0.2 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1530 45 18 20 -4.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CCC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417384 apj_human Human No 9.5 EC50 = 0.4 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1622 47 18 21 -3.7 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OCC3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3417384 apj_human Human No 9.5 EC50 = 0.4 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1622 47 18 21 -3.7 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OCC3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3184840 apj_human Human Yes 9.4 EC50 = 0.4 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3184840 apj_human Human Yes 9.4 EC50 = 0.4 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417379 apj_human Human No 9.4 EC50 = 0.5 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=NC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417379 apj_human Human No 9.4 EC50 = 0.5 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=NC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417291 apj_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1516 44 18 20 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417291 apj_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1516 44 18 20 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417386 apj_human Human No 9.2 EC50 = 0.6 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1542 45 18 20 -4.5 CCCCC(C(=O)N1CCCC1C(=O)NC(CC=CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417386 apj_human Human No 9.2 EC50 = 0.6 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1542 45 18 20 -4.5 CCCCC(C(=O)N1CCCC1C(=O)NC(CC=CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417379 apj_human Human No 9.1 EC50 = 0.7 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=NC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417379 apj_human Human No 9.1 EC50 = 0.7 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=NC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3184840 apj_human Human Yes 9.1 EC50 = 0.8 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3184840 apj_human Human Yes 9.1 EC50 = 0.8 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417390 apj_human Human No 9.1 EC50 = 0.9 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1530 44 18 20 -5.0 CCCCC(C(=O)N1CCCC1C(=O)NC(C)(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417390 apj_human Human No 9.1 EC50 = 0.9 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1530 44 18 20 -5.0 CCCCC(C(=O)N1CCCC1C(=O)NC(C)(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL414173 apj_human Human Yes 9.1 EC50 = 0.9 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1551 47 19 22 -7.1 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C(CCC(=O)N)N
CHEMBL414173 apj_human Human Yes 9.1 EC50 = 0.9 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1551 47 19 22 -7.1 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C(CCC(=O)N)N
CHEMBL3417385 apj_human Human No 9.0 EC50 = 0.9 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1620 46 18 21 -3.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)C(=O)C3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3417385 apj_human Human No 9.0 EC50 = 0.9 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1620 46 18 21 -3.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)C(=O)C3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3184840 apj_human Human Yes 9.0 EC50 = 1.1 Funct
Activity at human APJ receptor expressed in HEK293 cells assessed as dissociation of Galphai1 from Gbetagamma subunit after 5 mins by BRET assayActivity at human APJ receptor expressed in HEK293 cells assessed as dissociation of Galphai1 from Gbetagamma subunit after 5 mins by BRET assay
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3261778 apj_human Human No 9.0 EC50 = 1.1 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1119 34 14 14 -3.2 CC(C)CC(C(=O)N)NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3417384 apj_human Human No 9.0 EC50 = 1.1 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1622 47 18 21 -3.7 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OCC3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3414601 apj_human Human No 9.0 EC50 = 1.1 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1528 42 18 20 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC2(CCC3=CC=CC=C32)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3261778 apj_human Human No 9.0 EC50 = 1.1 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1119 34 14 14 -3.2 CC(C)CC(C(=O)N)NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3417384 apj_human Human No 9.0 EC50 = 1.1 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1622 47 18 21 -3.7 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OCC3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3414601 apj_human Human No 9.0 EC50 = 1.1 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1528 42 18 20 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC2(CCC3=CC=CC=C32)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3417375 apj_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1482 44 18 20 -5.4 CCCCC(C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3417388 apj_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1572 44 18 21 -4.1 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CSC3=CC=CC=C32)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3417377 apj_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1546 45 18 21 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OC)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417388 apj_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1572 44 18 21 -4.1 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CSC3=CC=CC=C32)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3417375 apj_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1482 44 18 20 -5.4 CCCCC(C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3417388 apj_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1572 44 18 21 -4.1 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CSC3=CC=CC=C32)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3417377 apj_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1546 45 18 21 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OC)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417388 apj_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1572 44 18 21 -4.1 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CSC3=CC=CC=C32)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3414601 apj_human Human No 8.9 EC50 = 1.4 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1528 42 18 20 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC2(CCC3=CC=CC=C32)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3417383 apj_human Human No 8.9 EC50 = 1.4 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1530 45 18 20 -4.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CCC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417378 apj_human Human No 8.9 EC50 = 1.4 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1530 44 18 20 -4.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)C)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417384 apj_human Human No 8.9 EC50 = 1.4 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of GalphaoA subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of GalphaoA subunit dissociation incubated for 5 mins by BRET assay
1622 47 18 21 -3.7 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OCC3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3184840 apj_human Human Yes 8.9 EC50 = 1.4 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3414601 apj_human Human No 8.9 EC50 = 1.4 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1528 42 18 20 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC2(CCC3=CC=CC=C32)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3417383 apj_human Human No 8.9 EC50 = 1.4 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1530 45 18 20 -4.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CCC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417378 apj_human Human No 8.9 EC50 = 1.4 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1530 44 18 20 -4.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)C)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417384 apj_human Human No 8.9 EC50 = 1.4 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of GalphaoA subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of GalphaoA subunit dissociation incubated for 5 mins by BRET assay
1622 47 18 21 -3.7 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OCC3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3184840 apj_human Human Yes 8.9 EC50 = 1.4 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3261787 apj_human Human No 8.8 EC50 = 1.7 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1091 34 13 14 -2.2 CC(C)CC(C(=O)N)NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3261787 apj_human Human No 8.8 EC50 = 1.7 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1091 34 13 14 -2.2 CC(C)CC(C(=O)N)NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3261776 apj_human Human No 8.7 EC50 = 1.9 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1201 37 16 16 -4.5 CC(C)CC(C(=O)N)NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C3CCCN3C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3809818 apj_human Human No 8.7 EC50 = 1.9 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3261776 apj_human Human No 8.7 EC50 = 1.9 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1201 37 16 16 -4.5 CC(C)CC(C(=O)N)NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C3CCCN3C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3809818 apj_human Human No 8.7 EC50 = 1.9 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3809767 apj_human Human No 8.0 EC50 = 10 Funct
Induction of HA-tagged human APJ receptor internalization expressed in HEK-293 cells after 30 mins by ELISAInduction of HA-tagged human APJ receptor internalization expressed in HEK-293 cells after 30 mins by ELISA
3951 123 59 54 -12.4 CC(C)CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)N1)NC(=O)C(CC(=O)N)NC(=O)C(CC2=CN=CN2)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCSC)NC(=O)C(C(C)O)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)N)NC(=O)C(C(C)C)NC(=O)C3CCCN3C(=O)C(CCCNC(=N)N)NC(=O)C4CCC(=O)N4)C(=O)NC(CCSC)C(=O)N5CCCC5C(=O)NC(CC(C)C)C(=O)NC(CC6=CN=CN6)C(=O)NC(CCCNC(=N)N)C(=O)NC(CO)C(=O)NC(C(C)C)C(=O)N7CCCC7C(=O)NC(CC8=CC=CC=C8)C(=O)N9CCCC9C(=O)O)CCCNC(=N)N)CCCNC(=N)N)CCC(=O)N
CHEMBL3809335 apj_human Human No 7.0 EC50 = 106 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1940 61 28 27 -5.1 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CS)N
CHEMBL3809035 apj_human Human No 6.0 EC50 = 1064 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1284 34 14 18 -2.7 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)N
CHEMBL3808736 apj_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1681 49 22 23 -3.9 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)NC(C)C(=O)O)NC(=O)C4CCCN4C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3808736 apj_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1681 49 22 23 -3.9 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)NC(C)C(=O)O)NC(=O)C4CCCN4C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3808818 apj_human Human No 5.9 EC50 = 1250 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1679 47 21 23 -4.6 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417384 apj_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment subunit dissociation incubated for 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment subunit dissociation incubated for 30 mins by BRET assay
1622 47 18 21 -3.7 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OCC3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3809537 apj_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1667 48 21 23 -5.8 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)N
CHEMBL3417384 apj_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment subunit dissociation incubated for 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment subunit dissociation incubated for 30 mins by BRET assay
1622 47 18 21 -3.7 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OCC3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3809537 apj_human Human No 6.9 EC50 = 138 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1667 48 21 23 -5.8 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)N
CHEMBL3261777 apj_human Human No 5.9 EC50 = 1383 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1116 33 14 15 -3.3 CC(C)CC(C(=O)N)NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C3CCCN3C(=O)C(C)NC(=O)C
CHEMBL3261777 apj_human Human No 5.9 EC50 = 1383 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1116 33 14 15 -3.3 CC(C)CC(C(=O)N)NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C3CCCN3C(=O)C(C)NC(=O)C
CHEMBL3810012 apj_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1647 45 21 22 -4.2 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(C)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3810012 apj_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1647 45 21 22 -4.2 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(C)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3809968 apj_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1691 47 20 22 -2.5 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(C)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3809136 apj_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1622 44 19 22 -2.4 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3808449 apj_human Human No 5.9 EC50 = 1423 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1706 48 21 22 -4.2 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)N)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3809972 apj_human Human No 6.8 EC50 = 147 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1622 44 19 22 -2.4 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3809035 apj_human Human No 7.8 EC50 = 15 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1284 34 14 18 -2.7 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)N
CHEMBL3810388 apj_human Human No 6.8 EC50 = 151 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1938 49 26 27 -5.2 CC(C)CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)N1)N)C(=O)NC(CCSC)C(=O)N2CCCC2C(=O)NC(CC(C)C)C(=O)NC(CC3=CN=CN3)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)C)C(=O)N4CCCC4C(=O)NC(CC5=CC=CC=C5)C(=O)N6CCCC6C(=O)O)CCCNC(=N)N)CCCNC(=N)N)CCC(=O)N
CHEMBL3809768 apj_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1622 44 19 22 -2.4 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C6CCC(=O)N6
CHEMBL3809818 apj_human Human No 7.8 EC50 = 16 Funct
Induction of HA-tagged human APJ receptor internalization expressed in HEK-293 cells after 30 mins by ELISAInduction of HA-tagged human APJ receptor internalization expressed in HEK-293 cells after 30 mins by ELISA
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3809538 apj_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1681 49 22 23 -3.9 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3809768 apj_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1622 44 19 22 -2.4 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C6CCC(=O)N6
CHEMBL3809818 apj_human Human No 7.8 EC50 = 16 Funct
Induction of HA-tagged human APJ receptor internalization expressed in HEK-293 cells after 30 mins by ELISAInduction of HA-tagged human APJ receptor internalization expressed in HEK-293 cells after 30 mins by ELISA
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3809739 apj_human Human Yes 6.8 EC50 = 166 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1707 48 21 23 -3.6 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3808761 apj_human Human No 6.8 EC50 = 167 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1689 48 21 22 -2.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(CC2=CN=CN2)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)N5CCCC5C(=O)O)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3810194 apj_human Human No 5.8 EC50 = 1730 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1641 46 20 22 -3.4 CC(C)CC(C(=O)NC(C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)N3CCCC3C(=O)O)NC(=O)C4CCCN4C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3261767 apj_human Human No 7.7 EC50 = 19 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1306 42 18 19 -6.8 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)C3CCCN3C(=O)C(CCCN=C(N)N)NC(=O)C(CCC(=O)N)N
CHEMBL3261767 apj_human Human No 7.7 EC50 = 19 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1306 42 18 19 -6.8 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)C3CCCN3C(=O)C(CCCN=C(N)N)NC(=O)C(CCC(=O)N)N
CHEMBL3809334 apj_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1665 46 21 23 -4.9 CC(C)C(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)N3CCCC3C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(CO)NC(=O)C(CC4=CN=CN4)NC(=O)C(C)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3338680 apj_human Human No 6.7 EC50 = 198.6 Funct
Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assayAgonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assay
1693 54 20 19 7.5 CCCCCCCCCCCCCCCC(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(C(C)O)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(CCCN=C(N)N)C(=O)N
CHEMBL3338680 apj_human Human No 6.7 EC50 = 198.6 Funct
Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assayAgonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assay
1693 54 20 19 7.5 CCCCCCCCCCCCCCCC(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(C(C)O)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(CCCN=C(N)N)C(=O)N
CHEMBL3417380 apj_human Human No 8.7 EC50 = 2 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CN=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417380 apj_human Human No 8.7 EC50 = 2 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CN=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3261789 apj_human Human No 8.7 EC50 = 2.2 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1076 33 12 13 -0.6 CCCCC(C(=O)NCC(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)N)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3261789 apj_human Human No 8.7 EC50 = 2.2 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1076 33 12 13 -0.6 CCCCC(C(=O)NCC(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)N)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3417380 apj_human Human No 8.6 EC50 = 2.3 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CN=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417380 apj_human Human No 8.6 EC50 = 2.3 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CN=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3414600 apj_human Human No 8.6 EC50 = 2.5 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1482 44 18 20 -5.4 CCCCC(C(=O)N1CCCC1C(=O)NC(C(C)CC)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3414600 apj_human Human No 8.6 EC50 = 2.5 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1482 44 18 20 -5.4 CCCCC(C(=O)N1CCCC1C(=O)NC(C(C)CC)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3338689 apj_human Human No 8.6 EC50 = 2.7 Funct
Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assayAgonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assay
1629 53 19 18 7.2 CCCCCCCCCCCCCCCC(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(C(C)O)C(=O)NC(C)C(=O)NC(CCCN=C(N)N)C(=O)N
CHEMBL3417376 apj_human Human No 8.6 EC50 = 2.7 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1468 43 18 20 -5.8 CCCCC(C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3417389 apj_human Human No 8.6 EC50 = 2.7 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1530 44 18 20 -5.0 CCCCC(C(=O)N1CCCC1C(=O)NC(C)(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417382 apj_human Human No 8.6 EC50 = 2.7 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1502 43 18 20 -5.5 CCCCC(C(=O)N1CCCC1C(=O)NC(C2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3338689 apj_human Human No 8.6 EC50 = 2.7 Funct
Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assayAgonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assay
1629 53 19 18 7.2 CCCCCCCCCCCCCCCC(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(C(C)O)C(=O)NC(C)C(=O)NC(CCCN=C(N)N)C(=O)N
CHEMBL3417376 apj_human Human No 8.6 EC50 = 2.7 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1468 43 18 20 -5.8 CCCCC(C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3417389 apj_human Human No 8.6 EC50 = 2.7 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1530 44 18 20 -5.0 CCCCC(C(=O)N1CCCC1C(=O)NC(C)(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417382 apj_human Human No 8.6 EC50 = 2.7 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1502 43 18 20 -5.5 CCCCC(C(=O)N1CCCC1C(=O)NC(C2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417390 apj_human Human No 8.6 EC50 = 2.8 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1530 44 18 20 -5.0 CCCCC(C(=O)N1CCCC1C(=O)NC(C)(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417390 apj_human Human No 8.6 EC50 = 2.8 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1530 44 18 20 -5.0 CCCCC(C(=O)N1CCCC1C(=O)NC(C)(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417375 apj_human Human No 8.5 EC50 = 2.9 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1482 44 18 20 -5.4 CCCCC(C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3417375 apj_human Human No 8.5 EC50 = 2.9 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1482 44 18 20 -5.4 CCCCC(C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3261766 apj_human Human No 7.7 EC50 = 20 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1403 43 18 20 -6.8 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C(CCC(=O)N)N
CHEMBL3261766 apj_human Human No 7.7 EC50 = 20 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1403 43 18 20 -6.8 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C(CCC(=O)N)N
CHEMBL3808449 apj_human Human No 7.7 EC50 = 20 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1706 48 21 22 -4.2 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)N)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3338686 apj_human Human No 7.7 EC50 = 21.5 Funct
Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assayAgonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assay
1691 54 19 18 9.1 CCCCCCCCCCCCCCCC(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(C)C(=O)NC(C)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(C(C)O)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(CCCN=C(N)N)C(=O)N
CHEMBL3338686 apj_human Human No 7.7 EC50 = 21.5 Funct
Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assayAgonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assay
1691 54 19 18 9.1 CCCCCCCCCCCCCCCC(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(C)C(=O)NC(C)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(C(C)O)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(CCCN=C(N)N)C(=O)N
CHEMBL3810194 apj_human Human No 7.7 EC50 = 22 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1641 46 20 22 -3.4 CC(C)CC(C(=O)NC(C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)N3CCCC3C(=O)O)NC(=O)C4CCCN4C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3338699 apj_human Human No 6.7 EC50 = 225.5 Funct
Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assayAgonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assay
1836 60 23 22 7.7 CCCCCCCCCCCCCCCC(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(C(C)O)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(=O)O)C(=O)N
CHEMBL3338699 apj_human Human No 6.7 EC50 = 225.5 Funct
Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assayAgonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assay
1836 60 23 22 7.7 CCCCCCCCCCCCCCCC(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(C(C)O)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(=O)O)C(=O)N
CHEMBL3809291 apj_human Human No 6.6 EC50 = 229 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1691 48 21 23 -4.6 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CO)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3261768 apj_human Human No 5.6 EC50 = 2350 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1174 37 17 17 -7.2 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)C3CCCN3C(=O)C(CCCN=C(N)N)NC(=O)C(CCC(=O)N)N
CHEMBL3261768 apj_human Human No 5.6 EC50 = 2350 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1174 37 17 17 -7.2 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)C3CCCN3C(=O)C(CCCN=C(N)N)NC(=O)C(CCC(=O)N)N
CHEMBL3261783 apj_human Human No 6.6 EC50 = 237 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1093 35 15 14 -3.5 CC(C)CC(C(=O)N)NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3261783 apj_human Human No 6.6 EC50 = 237 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1093 35 15 14 -3.5 CC(C)CC(C(=O)N)NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3184840 apj_human Human Yes 7.6 EC50 = 24 Funct
Induction of human HA-tagged APJ receptor internalization expressed in HEK293 cells after 30 mins by ELISAInduction of human HA-tagged APJ receptor internalization expressed in HEK293 cells after 30 mins by ELISA
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3808818 apj_human Human No 7.6 EC50 = 24 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1679 47 21 23 -4.6 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3184840 apj_human Human Yes 7.6 EC50 = 26 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of beta-arrestin-1 recruitment subunit dissociation incubated for 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of beta-arrestin-1 recruitment subunit dissociation incubated for 30 mins by BRET assay
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3184840 apj_human Human Yes 7.6 EC50 = 26 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of beta-arrestin-1 recruitment subunit dissociation incubated for 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of beta-arrestin-1 recruitment subunit dissociation incubated for 30 mins by BRET assay
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3808736 apj_human Human No 6.6 EC50 = 266 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1681 49 22 23 -3.9 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)NC(C)C(=O)O)NC(=O)C4CCCN4C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3808736 apj_human Human No 6.6 EC50 = 266 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1681 49 22 23 -3.9 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)NC(C)C(=O)O)NC(=O)C4CCCN4C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3809149 apj_human Human No 6.5 EC50 = 288 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1675 47 20 22 -3.5 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3184840 apj_human Human Yes 7.5 EC50 = 29 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment subunit dissociation incubated for 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment subunit dissociation incubated for 30 mins by BRET assay
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3184840 apj_human Human Yes 7.5 EC50 = 29 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment subunit dissociation incubated for 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment subunit dissociation incubated for 30 mins by BRET assay
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417381 apj_human Human No 8.5 EC50 = 3 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=N2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417381 apj_human Human No 8.5 EC50 = 3 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=N2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3414600 apj_human Human No 8.5 EC50 = 3.1 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1482 44 18 20 -5.4 CCCCC(C(=O)N1CCCC1C(=O)NC(C(C)CC)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3414600 apj_human Human No 8.5 EC50 = 3.1 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1482 44 18 20 -5.4 CCCCC(C(=O)N1CCCC1C(=O)NC(C(C)CC)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3261786 apj_human Human No 8.5 EC50 = 3.2 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1076 33 12 13 -0.6 CCCCC(C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NCC(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)N)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3261786 apj_human Human No 8.5 EC50 = 3.2 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1076 33 12 13 -0.6 CCCCC(C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NCC(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)N)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3417386 apj_human Human No 8.5 EC50 = 3.4 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1542 45 18 20 -4.5 CCCCC(C(=O)N1CCCC1C(=O)NC(CC=CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417386 apj_human Human No 8.5 EC50 = 3.4 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1542 45 18 20 -4.5 CCCCC(C(=O)N1CCCC1C(=O)NC(CC=CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417381 apj_human Human No 8.4 EC50 = 3.6 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=N2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417381 apj_human Human No 8.4 EC50 = 3.6 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=N2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3818972 apj_human Human No 5.5 EC50 = 3000 Funct
Agonist activity at human APJ receptor expressed in cells c-expressing Galphaq16 assessed as calcium mobilization by FLIPR assayAgonist activity at human APJ receptor expressed in cells c-expressing Galphaq16 assessed as calcium mobilization by FLIPR assay
518 11 2 7 5.1 COC1=C(C(=CC=C1)OC)C2=CC(=NN2C3=CC=C(C=C3)F)C(=O)NC(CCC4=CC=CC=C4)CC(=O)O
CHEMBL3818972 apj_human Human No 5.5 EC50 = 3000 Funct
Agonist activity at human APJ receptor expressed in cells c-expressing Galphaq16 assessed as calcium mobilization by FLIPR assayAgonist activity at human APJ receptor expressed in cells c-expressing Galphaq16 assessed as calcium mobilization by FLIPR assay
518 11 2 7 5.1 COC1=C(C(=CC=C1)OC)C2=CC(=NN2C3=CC=C(C=C3)F)C(=O)NC(CCC4=CC=CC=C4)CC(=O)O
CHEMBL3261779 apj_human Human No 7.5 EC50 = 31 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1093 35 15 14 -3.5 CC(C)CC(C(=O)N)NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3261779 apj_human Human No 7.5 EC50 = 31 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1093 35 15 14 -3.5 CC(C)CC(C(=O)N)NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3810012 apj_human Human No 6.5 EC50 = 316 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1647 45 21 22 -4.2 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(C)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3810012 apj_human Human No 6.5 EC50 = 316 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1647 45 21 22 -4.2 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(C)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3809538 apj_human Human No 6.5 EC50 = 326 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1681 49 22 23 -3.9 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3262012 apj_human Human No 7.5 EC50 = 33 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1061 32 11 12 1.1 CCCCC(C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C)C(=O)NC(CCCC)C(=O)NCC(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)N)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3262012 apj_human Human No 7.5 EC50 = 33 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1061 32 11 12 1.1 CCCCC(C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C)C(=O)NC(CCCC)C(=O)NCC(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)N)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3338677 apj_human Human No 7.5 EC50 = 33.7 Funct
Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assayAgonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assay
1721 55 20 19 8.5 CCCCCCCCCCCCCCCC(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(C(C)O)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(CCCN=C(N)N)C(=O)N
CHEMBL3338677 apj_human Human No 7.5 EC50 = 33.7 Funct
Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assayAgonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assay
1721 55 20 19 8.5 CCCCCCCCCCCCCCCC(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(C(C)O)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(CCCN=C(N)N)C(=O)N
CHEMBL3809136 apj_human Human No 6.5 EC50 = 338 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1622 44 19 22 -2.4 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3809477 apj_human Human No 7.4 EC50 = 36 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1631 46 21 23 -5.2 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C)C(=O)N3CCCC3C(=O)O)NC(=O)C4CCCN4C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3809477 apj_human Human No 7.4 EC50 = 36 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1631 46 21 23 -5.2 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C)C(=O)N3CCCC3C(=O)O)NC(=O)C4CCCN4C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3809739 apj_human Human Yes 7.4 EC50 = 36 Funct
Induction of HA-tagged human APJ receptor internalization expressed in HEK-293 cells after 30 mins by ELISAInduction of HA-tagged human APJ receptor internalization expressed in HEK-293 cells after 30 mins by ELISA
1707 48 21 23 -3.6 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3809477 apj_human Human No 5.4 EC50 = 3646 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1631 46 21 23 -5.2 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C)C(=O)N3CCCC3C(=O)O)NC(=O)C4CCCN4C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3809477 apj_human Human No 5.4 EC50 = 3646 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1631 46 21 23 -5.2 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C)C(=O)N3CCCC3C(=O)O)NC(=O)C4CCCN4C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3819625 apj_human Human No 5.4 EC50 = 3700 Funct
Agonist activity at APJ receptor (unknown origin)Agonist activity at APJ receptor (unknown origin)
359 4 0 5 4.7 CC1=CC(=O)C(=CC1=NOS(=O)(=O)C2=CC=CC=C2)C3CCCCC3
CHEMBL3819625 apj_human Human No 5.4 EC50 = 3700 Funct
Agonist activity at APJ receptor (unknown origin)Agonist activity at APJ receptor (unknown origin)
359 4 0 5 4.7 CC1=CC(=O)C(=CC1=NOS(=O)(=O)C2=CC=CC=C2)C3CCCCC3
CHEMBL3417382 apj_human Human No 8.4 EC50 = 4.2 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1502 43 18 20 -5.5 CCCCC(C(=O)N1CCCC1C(=O)NC(C2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417382 apj_human Human No 8.4 EC50 = 4.2 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1502 43 18 20 -5.5 CCCCC(C(=O)N1CCCC1C(=O)NC(C2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3261773 apj_human Human No 8.4 EC50 = 4.4 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1219 38 16 17 -5.1 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)C3CCCN3C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3261773 apj_human Human No 8.4 EC50 = 4.4 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1219 38 16 17 -5.1 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)C3CCCN3C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3417291 apj_human Human No 8.4 EC50 = 4.5 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1516 44 18 20 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417291 apj_human Human No 8.4 EC50 = 4.5 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1516 44 18 20 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3261774 apj_human Human No 8.3 EC50 = 4.7 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1235 37 16 16 -4.2 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3417376 apj_human Human No 8.3 EC50 = 4.7 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1468 43 18 20 -5.8 CCCCC(C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3261774 apj_human Human No 8.3 EC50 = 4.7 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1235 37 16 16 -4.2 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3417376 apj_human Human No 8.3 EC50 = 4.7 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1468 43 18 20 -5.8 CCCCC(C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3338681 apj_human Human No 7.4 EC50 = 41.3 Funct
Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assayAgonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assay
1691 54 19 18 9.1 CCCCCCCCCCCCCCCC(=O)NC(C(C)C)C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(C(C)O)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(CCCN=C(N)N)C(=O)N
CHEMBL3338681 apj_human Human No 7.4 EC50 = 41.3 Funct
Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assayAgonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assay
1691 54 19 18 9.1 CCCCCCCCCCCCCCCC(=O)NC(C(C)C)C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(C(C)O)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(CCCN=C(N)N)C(=O)N
CHEMBL3261788 apj_human Human No 7.4 EC50 = 44 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1125 34 13 14 -1.9 CC(C)CC(C(=O)N)NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCCCN)NC(=O)C3CCCN3C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3261788 apj_human Human No 7.4 EC50 = 44 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1125 34 13 14 -1.9 CC(C)CC(C(=O)N)NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCCCN)NC(=O)C3CCCN3C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3809767 apj_human Human No 7.4 EC50 = 45 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
3951 123 59 54 -12.4 CC(C)CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)N1)NC(=O)C(CC(=O)N)NC(=O)C(CC2=CN=CN2)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCSC)NC(=O)C(C(C)O)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)N)NC(=O)C(C(C)C)NC(=O)C3CCCN3C(=O)C(CCCNC(=N)N)NC(=O)C4CCC(=O)N4)C(=O)NC(CCSC)C(=O)N5CCCC5C(=O)NC(CC(C)C)C(=O)NC(CC6=CN=CN6)C(=O)NC(CCCNC(=N)N)C(=O)NC(CO)C(=O)NC(C(C)C)C(=O)N7CCCC7C(=O)NC(CC8=CC=CC=C8)C(=O)N9CCCC9C(=O)O)CCCNC(=N)N)CCCNC(=N)N)CCC(=O)N
CHEMBL3338677 apj_human Human No 6.3 EC50 = 470 Funct
Agonist activity at human APJ receptor expressed in Chem-5 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human APJ receptor expressed in Chem-5 cells assessed as calcium mobilization by FLIPR assay
1721 55 20 19 8.5 CCCCCCCCCCCCCCCC(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(C(C)O)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(CCCN=C(N)N)C(=O)N
CHEMBL3338677 apj_human Human No 6.3 EC50 = 470 Funct
Agonist activity at human APJ receptor expressed in Chem-5 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human APJ receptor expressed in Chem-5 cells assessed as calcium mobilization by FLIPR assay
1721 55 20 19 8.5 CCCCCCCCCCCCCCCC(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(C(C)O)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(CCCN=C(N)N)C(=O)N
CHEMBL3809035 apj_human Human No 6.3 EC50 = 476 Funct
Induction of HA-tagged human APJ receptor internalization expressed in HEK-293 cells after 30 mins by ELISAInduction of HA-tagged human APJ receptor internalization expressed in HEK-293 cells after 30 mins by ELISA
1284 34 14 18 -2.7 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)N
CHEMBL3809768 apj_human Human No 6.3 EC50 = 484 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1622 44 19 22 -2.4 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C6CCC(=O)N6
CHEMBL3809768 apj_human Human No 6.3 EC50 = 484 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1622 44 19 22 -2.4 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C6CCC(=O)N6
CHEMBL3261784 apj_human Human No 6.3 EC50 = 494 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1091 34 13 14 -2.2 CC(C)CC(C(=O)N)NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C2CCCN2C(=O)C(CCCCN)NC(=O)C
CHEMBL3261784 apj_human Human No 6.3 EC50 = 494 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1091 34 13 14 -2.2 CC(C)CC(C(=O)N)NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C2CCCN2C(=O)C(CCCCN)NC(=O)C
CHEMBL3809767 apj_human Human No 8.3 EC50 = 5.3 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
3951 123 59 54 -12.4 CC(C)CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)N1)NC(=O)C(CC(=O)N)NC(=O)C(CC2=CN=CN2)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCSC)NC(=O)C(C(C)O)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)N)NC(=O)C(C(C)C)NC(=O)C3CCCN3C(=O)C(CCCNC(=N)N)NC(=O)C4CCC(=O)N4)C(=O)NC(CCSC)C(=O)N5CCCC5C(=O)NC(CC(C)C)C(=O)NC(CC6=CN=CN6)C(=O)NC(CCCNC(=N)N)C(=O)NC(CO)C(=O)NC(C(C)C)C(=O)N7CCCC7C(=O)NC(CC8=CC=CC=C8)C(=O)N9CCCC9C(=O)O)CCCNC(=N)N)CCCNC(=N)N)CCC(=O)N
CHEMBL3809149 apj_human Human No 8.2 EC50 = 5.7 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1675 47 20 22 -3.5 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3184840 apj_human Human Yes 8.2 EC50 = 5.9 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of GalphaoA subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of GalphaoA subunit dissociation incubated for 5 mins by BRET assay
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3184840 apj_human Human Yes 8.2 EC50 = 5.9 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of GalphaoA subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of GalphaoA subunit dissociation incubated for 5 mins by BRET assay
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3809707 apj_human Human No 5.3 EC50 = 5182 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1681 49 22 23 -3.9 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)NC(C)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CCCC3C(=O)O)NC(=O)C4CCCN4C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3262011 apj_human Human No 6.3 EC50 = 539 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1104 37 12 13 -0.2 CCCCC(C(=O)NCCCCCCCC(=O)NC(C)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NCC(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)N)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3262011 apj_human Human No 6.3 EC50 = 539 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1104 37 12 13 -0.2 CCCCC(C(=O)NCCCCCCCC(=O)NC(C)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NCC(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)N)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3417387 apj_human Human No 8.2 EC50 = 6 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1618 44 18 20 -3.3 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2C3=CC=CC=C3CC4=CC=CC=C24)C(=O)O)NC(=O)C5CCCN5C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC6=CN=CN6)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C7CCCN7C(=O)C(CCCN=C(N)N)NC(=O)C8CCC(=O)N8
CHEMBL3417387 apj_human Human No 8.2 EC50 = 6 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of Galphai1 subunit dissociation incubated for 5 mins by BRET assay
1618 44 18 20 -3.3 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2C3=CC=CC=C3CC4=CC=CC=C24)C(=O)O)NC(=O)C5CCCN5C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC6=CN=CN6)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C7CCCN7C(=O)C(CCCN=C(N)N)NC(=O)C8CCC(=O)N8
CHEMBL3809291 apj_human Human No 8.2 EC50 = 6.5 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1691 48 21 23 -4.6 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CO)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3810388 apj_human Human No 8.2 EC50 = 6.6 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1938 49 26 27 -5.2 CC(C)CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)N1)N)C(=O)NC(CCSC)C(=O)N2CCCC2C(=O)NC(CC(C)C)C(=O)NC(CC3=CN=CN3)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)C)C(=O)N4CCCC4C(=O)NC(CC5=CC=CC=C5)C(=O)N6CCCC6C(=O)O)CCCNC(=N)N)CCCNC(=N)N)CCC(=O)N
CHEMBL3809335 apj_human Human No 8.2 EC50 = 6.8 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1940 61 28 27 -5.1 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CS)N
CHEMBL3184840 apj_human Human Yes 7.2 EC50 = 60 Funct
Activity at GFP10-tagged human APJ receptor expressed in HEK293 cells assessed as induction of RlucII-tagged beta-arrestin-2 recruitment after 30 mins by BRET assayActivity at GFP10-tagged human APJ receptor expressed in HEK293 cells assessed as induction of RlucII-tagged beta-arrestin-2 recruitment after 30 mins by BRET assay
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3809707 apj_human Human No 7.2 EC50 = 61 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1681 49 22 23 -3.9 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)NC(C)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CCCC3C(=O)O)NC(=O)C4CCCN4C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3261782 apj_human Human No 6.2 EC50 = 637 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1062 30 13 13 -2.9 CC(C)CC(C(=O)N)NC(=O)C1CCCN1C(=O)CNC(=O)C(C)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3261782 apj_human Human No 6.2 EC50 = 637 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1062 30 13 13 -2.9 CC(C)CC(C(=O)N)NC(=O)C1CCCN1C(=O)CNC(=O)C(C)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3809818 apj_human Human No 7.2 EC50 = 68 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3809818 apj_human Human No 7.2 EC50 = 68 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3261775 apj_human Human No 6.2 EC50 = 691 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1187 36 16 16 -4.8 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(C(C)C)C(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)C3CCCN3C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3261775 apj_human Human No 6.2 EC50 = 691 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1187 36 16 16 -4.8 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(C(C)C)C(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)C3CCCN3C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3417384 apj_human Human No 8.1 EC50 = 7.4 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of beta-arrestin-1 recruitment subunit dissociation incubated for 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of beta-arrestin-1 recruitment subunit dissociation incubated for 30 mins by BRET assay
1622 47 18 21 -3.7 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OCC3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3417384 apj_human Human No 8.1 EC50 = 7.4 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of beta-arrestin-1 recruitment subunit dissociation incubated for 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as induction of beta-arrestin-1 recruitment subunit dissociation incubated for 30 mins by BRET assay
1622 47 18 21 -3.7 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OCC3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3261790 apj_human Human No 7.1 EC50 = 73 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1124 34 12 13 0.1 CCCCC(C(=O)NC(CCC1=CC=CC=C1)C(=O)NC(C)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CC(C)C)C(=O)N)NC(=O)C3CCCN3C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3261790 apj_human Human No 7.1 EC50 = 73 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1124 34 12 13 0.1 CCCCC(C(=O)NC(CCC1=CC=CC=C1)C(=O)NC(C)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CC(C)C)C(=O)N)NC(=O)C3CCCN3C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3809739 apj_human Human Yes 8.1 EC50 = 8.6 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1707 48 21 23 -3.6 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3261780 apj_human Human No 8.1 EC50 = 8.9 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1034 30 12 13 -2.0 CC(C)CC(C(=O)N)NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3261780 apj_human Human No 8.1 EC50 = 8.9 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1034 30 12 13 -2.0 CC(C)CC(C(=O)N)NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3817879 apj_human Human No 6.1 EC50 = 800 Funct
Agonist activity at human APJ receptor expressed in cells c-expressing Galphaq16 assessed as calcium mobilization by FLIPR assayAgonist activity at human APJ receptor expressed in cells c-expressing Galphaq16 assessed as calcium mobilization by FLIPR assay
524 11 2 7 6.2 COC1=C(C(=CC=C1)OC)C2=CC(=NN2C3=CC=C(C=C3)F)C(=O)NC(CCC4CCCCC4)CC(=O)O
CHEMBL3817879 apj_human Human No 6.1 EC50 = 800 Funct
Agonist activity at human APJ receptor expressed in cells c-expressing Galphaq16 assessed as calcium mobilization by FLIPR assayAgonist activity at human APJ receptor expressed in cells c-expressing Galphaq16 assessed as calcium mobilization by FLIPR assay
524 11 2 7 6.2 COC1=C(C(=CC=C1)OC)C2=CC(=NN2C3=CC=C(C=C3)F)C(=O)NC(CCC4CCCCC4)CC(=O)O
CHEMBL3809968 apj_human Human No 7.1 EC50 = 82 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1691 47 20 22 -2.5 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(C)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3262016 apj_human Human No 7.1 EC50 = 83.2 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1458 42 18 21 -7.5 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3262016 apj_human Human No 7.1 EC50 = 83.2 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1458 42 18 21 -7.5 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3808761 apj_human Human No 8.0 EC50 = 9.2 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as dissociation of G-alpha-i1 protein after 5 mins by BRET assay
1689 48 21 22 -2.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(CC2=CN=CN2)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)N5CCCC5C(=O)O)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3261781 apj_human Human No 6.0 EC50 = 936 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1077 32 14 14 -4.5 CC(C)CC(C(=O)N)NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCCN=C(N)N)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3261781 apj_human Human No 6.0 EC50 = 936 Funct
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilizationAgonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
1077 32 14 14 -4.5 CC(C)CC(C(=O)N)NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCCN=C(N)N)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL3818101 apj_human Human No 5.0 EC50 = 9400 Funct
Agonist activity at human APJ receptor expressed in cells c-expressing Galphaq16 assessed as calcium mobilization by FLIPR assayAgonist activity at human APJ receptor expressed in cells c-expressing Galphaq16 assessed as calcium mobilization by FLIPR assay
470 10 2 7 4.5 CC(C)CC(CC(=O)O)NC(=O)C1=NN(C(=C1)C2=C(C=CC=C2OC)OC)C3=CC=C(C=C3)F
CHEMBL3818101 apj_human Human No 5.0 EC50 = 9400 Funct
Agonist activity at human APJ receptor expressed in cells c-expressing Galphaq16 assessed as calcium mobilization by FLIPR assayAgonist activity at human APJ receptor expressed in cells c-expressing Galphaq16 assessed as calcium mobilization by FLIPR assay
470 10 2 7 4.5 CC(C)CC(CC(=O)O)NC(=O)C1=NN(C(=C1)C2=C(C=CC=C2OC)OC)C3=CC=C(C=C3)F
CHEMBL3809334 apj_human Human No 6.0 EC50 = 942 Funct
Agonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assayAgonist activity at human APJ receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment after 30 mins by BRET assay
1665 46 21 23 -4.9 CC(C)C(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)N3CCCC3C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(CO)NC(=O)C(CC4=CN=CN4)NC(=O)C(C)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417387 apj_human Human No 7.0 EC50 = 95 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1618 44 18 20 -3.3 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2C3=CC=CC=C3CC4=CC=CC=C24)C(=O)O)NC(=O)C5CCCN5C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC6=CN=CN6)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C7CCCN7C(=O)C(CCCN=C(N)N)NC(=O)C8CCC(=O)N8
CHEMBL3417387 apj_human Human No 7.0 EC50 = 95 Funct
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assayAgonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated for 30 mins by TR-FRET assay
1618 44 18 20 -3.3 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2C3=CC=CC=C3CC4=CC=CC=C24)C(=O)O)NC(=O)C5CCCN5C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC6=CN=CN6)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C7CCCN7C(=O)C(CCCN=C(N)N)NC(=O)C8CCC(=O)N8
CHEMBL3338687 apj_human Human No 7.0 EC50 = 95.7 Funct
Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assayAgonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assay
1629 53 19 18 7.2 CCCCCCCCCCCCCCCC(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(CCCN=C(N)N)C(=O)N
CHEMBL3338687 apj_human Human No 7.0 EC50 = 95.7 Funct
Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assayAgonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assay
1629 53 19 18 7.2 CCCCCCCCCCCCCCCC(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(CCCN=C(N)N)C(=O)N
CHEMBL3818506 apj_human Human No 5.0 EC50 = 9900 Funct
Agonist activity at human APJ receptor expressed in cells c-expressing Galphaq16 assessed as calcium mobilization by FLIPR assayAgonist activity at human APJ receptor expressed in cells c-expressing Galphaq16 assessed as calcium mobilization by FLIPR assay
496 9 2 7 5.1 COC1=C(C(=CC=C1)OC)C2=CC(=NN2C3=CC=C(C=C3)F)C(=O)NC(CC(=O)O)C4CCCCC4
CHEMBL3818506 apj_human Human No 5.0 EC50 = 9900 Funct
Agonist activity at human APJ receptor expressed in cells c-expressing Galphaq16 assessed as calcium mobilization by FLIPR assayAgonist activity at human APJ receptor expressed in cells c-expressing Galphaq16 assessed as calcium mobilization by FLIPR assay
496 9 2 7 5.1 COC1=C(C(=CC=C1)OC)C2=CC(=NN2C3=CC=C(C=C3)F)C(=O)NC(CC(=O)O)C4CCCCC4
CHEMBL3417384 apj_human Human No 10.7 IC50 = 0.0 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1622 47 18 21 -3.7 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OCC3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3417384 apj_human Human No 10.7 IC50 = 0.0 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1622 47 18 21 -3.7 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OCC3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3417378 apj_human Human No 9.6 IC50 = 0.3 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1530 44 18 20 -4.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)C)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417378 apj_human Human No 9.6 IC50 = 0.3 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1530 44 18 20 -4.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)C)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417389 apj_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1530 44 18 20 -5.0 CCCCC(C(=O)N1CCCC1C(=O)NC(C)(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417389 apj_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1530 44 18 20 -5.0 CCCCC(C(=O)N1CCCC1C(=O)NC(C)(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417385 apj_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1620 46 18 21 -3.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)C(=O)C3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3417385 apj_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1620 46 18 21 -3.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)C(=O)C3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3417377 apj_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1546 45 18 21 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OC)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417377 apj_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1546 45 18 21 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OC)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417390 apj_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1530 44 18 20 -5.0 CCCCC(C(=O)N1CCCC1C(=O)NC(C)(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417390 apj_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1530 44 18 20 -5.0 CCCCC(C(=O)N1CCCC1C(=O)NC(C)(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3184840 apj_human Human Yes 8.9 IC50 = 1.2 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3184840 apj_human Human Yes 8.9 IC50 = 1.2 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417379 apj_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=NC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417379 apj_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=NC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417386 apj_human Human No 8.8 IC50 = 1.5 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1542 45 18 20 -4.5 CCCCC(C(=O)N1CCCC1C(=O)NC(CC=CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417386 apj_human Human No 8.8 IC50 = 1.5 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1542 45 18 20 -4.5 CCCCC(C(=O)N1CCCC1C(=O)NC(CC=CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417380 apj_human Human No 8.8 IC50 = 1.6 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CN=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417380 apj_human Human No 8.8 IC50 = 1.6 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CN=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3414601 apj_human Human No 8.8 IC50 = 1.7 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1528 42 18 20 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC2(CCC3=CC=CC=C32)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3414601 apj_human Human No 8.8 IC50 = 1.7 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1528 42 18 20 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC2(CCC3=CC=CC=C32)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3414600 apj_human Human No 7.9 IC50 = 11.4 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1482 44 18 20 -5.4 CCCCC(C(=O)N1CCCC1C(=O)NC(C(C)CC)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3414600 apj_human Human No 7.9 IC50 = 11.4 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1482 44 18 20 -5.4 CCCCC(C(=O)N1CCCC1C(=O)NC(C(C)CC)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL1382320 apj_human Human Yes 5.0 IC50 = 11000 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
444 6 1 7 2.4 C1COCCN1S(=O)(=O)C2=CC=C(C=C2)NC(=O)CSC3=CC=CC4=C3N=CC=C4
CHEMBL1382320 apj_human Human Yes 5.0 IC50 = 11000 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
444 6 1 7 2.4 C1COCCN1S(=O)(=O)C2=CC=C(C=C2)NC(=O)CSC3=CC=CC4=C3N=CC=C4
CHEMBL1406895 apj_human Human Yes 4.9 IC50 = 12100 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
438 4 1 5 3.8 COC(=O)C1=NN(C(C1)(C2=CC=C(C=C2)Cl)O)C(=O)C3=CC(=CC=C3)Br
CHEMBL1406895 apj_human Human Yes 4.9 IC50 = 12100 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
438 4 1 5 3.8 COC(=O)C1=NN(C(C1)(C2=CC=C(C=C2)Cl)O)C(=O)C3=CC(=CC=C3)Br
CHEMBL2158328 apj_human Human No 4.9 IC50 = 12800 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
432 6 0 7 4.6 CC1=CC=C(C=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC(=C(C=C3)Cl)[N+](=O)[O-]
CHEMBL2158328 apj_human Human No 4.9 IC50 = 12800 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
432 6 0 7 4.6 CC1=CC=C(C=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC(=C(C=C3)Cl)[N+](=O)[O-]
CHEMBL3417387 apj_human Human No 7.9 IC50 = 13.7 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1618 44 18 20 -3.3 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2C3=CC=CC=C3CC4=CC=CC=C24)C(=O)O)NC(=O)C5CCCN5C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC6=CN=CN6)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C7CCCN7C(=O)C(CCCN=C(N)N)NC(=O)C8CCC(=O)N8
CHEMBL3417387 apj_human Human No 7.9 IC50 = 13.7 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1618 44 18 20 -3.3 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2C3=CC=CC=C3CC4=CC=CC=C24)C(=O)O)NC(=O)C5CCCN5C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC6=CN=CN6)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C7CCCN7C(=O)C(CCCN=C(N)N)NC(=O)C8CCC(=O)N8
CHEMBL1557648 apj_human Human Yes 4.9 IC50 = 13900 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
300 3 1 4 3.2 C1=CC=C(C=C1)C2=NN=C(O2)NC(=O)C3=CC=C(C=C3)Cl
CHEMBL1557648 apj_human Human Yes 4.9 IC50 = 13900 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
300 3 1 4 3.2 C1=CC=C(C=C1)C2=NN=C(O2)NC(=O)C3=CC=C(C=C3)Cl
CHEMBL3417382 apj_human Human No 7.8 IC50 = 14.3 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1502 43 18 20 -5.5 CCCCC(C(=O)N1CCCC1C(=O)NC(C2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417382 apj_human Human No 7.9 IC50 = 14.3 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1502 43 18 20 -5.5 CCCCC(C(=O)N1CCCC1C(=O)NC(C2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL1309871 apj_human Human Yes 4.8 IC50 = 14800 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
382 4 2 3 4.3 C1=CC=C(C=C1)C2=NN(C(=C2)C(=O)NNC(=O)C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL1309871 apj_human Human Yes 4.8 IC50 = 14800 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
382 4 2 3 4.3 C1=CC=C(C=C1)C2=NN(C(=C2)C(=O)NNC(=O)C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL1346478 apj_human Human Yes 5.8 IC50 = 1750 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
434 6 0 9 3.2 CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC(=C(C=C3)Cl)[N+](=O)[O-]
CHEMBL2158347 apj_human Human Yes 5.8 IC50 = 1750 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
385 6 0 9 2.2 C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)[N+](=O)[O-]
CHEMBL1346478 apj_human Human Yes 5.8 IC50 = 1750 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
434 6 0 9 3.2 CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC(=C(C=C3)Cl)[N+](=O)[O-]
CHEMBL2158347 apj_human Human Yes 5.8 IC50 = 1750 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
385 6 0 9 2.2 C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)[N+](=O)[O-]
CHEMBL3417376 apj_human Human No 7.7 IC50 = 18.2 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1468 43 18 20 -5.8 CCCCC(C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3417376 apj_human Human No 7.7 IC50 = 18.2 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1468 43 18 20 -5.8 CCCCC(C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL2158350 apj_human Human Yes 4.7 IC50 = 18200 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
419 6 0 7 3.1 C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)Br
CHEMBL2158350 apj_human Human Yes 4.7 IC50 = 18200 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
419 6 0 7 3.1 C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)Br
CHEMBL1437683 apj_human Human Yes 4.7 IC50 = 18800 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
332 2 0 8 2.7 C1=CC(=CC(=C1)S(=O)(=O)C2=NC=C(C=C2)[N+](=O)[O-])C(F)(F)F
CHEMBL1437683 apj_human Human Yes 4.7 IC50 = 18800 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
332 2 0 8 2.7 C1=CC(=CC(=C1)S(=O)(=O)C2=NC=C(C=C2)[N+](=O)[O-])C(F)(F)F
CHEMBL1524932 apj_human Human Yes 4.7 IC50 = 19300 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
386 5 1 5 2.4 CN1C2=CC=CC=C2N=C1C3=C(N(C4=NC5=CC=CC=C5N=C34)CCCOC)N
CHEMBL1524932 apj_human Human Yes 4.7 IC50 = 19300 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
386 5 1 5 2.4 CN1C2=CC=CC=C2N=C1C3=C(N(C4=NC5=CC=CC=C5N=C34)CCCOC)N
CHEMBL1477528 apj_human Human Yes 4.7 IC50 = 19700 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
420 5 1 6 3.5 CC1=CC=CC=C1CS(=O)(=O)C2=NC=C(C(=N2)C(=O)NC3=CC=C(C=C3)F)Cl
CHEMBL1477528 apj_human Human Yes 4.7 IC50 = 19700 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
420 5 1 6 3.5 CC1=CC=CC=C1CS(=O)(=O)C2=NC=C(C(=N2)C(=O)NC3=CC=C(C=C3)F)Cl
CHEMBL3417291 apj_human Human No 8.6 IC50 = 2.6 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1516 44 18 20 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417291 apj_human Human No 8.6 IC50 = 2.6 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1516 44 18 20 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417388 apj_human Human No 8.6 IC50 = 2.8 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1572 44 18 21 -4.1 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CSC3=CC=CC=C32)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3417388 apj_human Human No 8.6 IC50 = 2.8 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1572 44 18 21 -4.1 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CSC3=CC=CC=C32)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL2158277 apj_human Human Yes 4.7 IC50 = 20600 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
422 6 0 10 3.7 CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)C(F)(F)F
CHEMBL2158277 apj_human Human Yes 4.7 IC50 = 20600 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
422 6 0 10 3.7 CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)C(F)(F)F
CHEMBL1431608 apj_human Human Yes 4.6 IC50 = 23400 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
278 2 0 5 2.2 CC1=CC=C(C=C1)S(=O)(=O)C2=NC=C(C=C2)[N+](=O)[O-]
CHEMBL1431608 apj_human Human Yes 4.6 IC50 = 23400 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
278 2 0 5 2.2 CC1=CC=C(C=C1)S(=O)(=O)C2=NC=C(C=C2)[N+](=O)[O-]
CHEMBL2158326 apj_human Human No 4.6 IC50 = 24000 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
502 7 0 11 5.4 C1=CC(=CC=C1OC(F)(F)F)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC(=C(C=C3)Cl)[N+](=O)[O-]
CHEMBL2158326 apj_human Human No 4.6 IC50 = 24000 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
502 7 0 11 5.4 C1=CC(=CC=C1OC(F)(F)F)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC(=C(C=C3)Cl)[N+](=O)[O-]
CHEMBL1904956 apj_human Human Yes 4.5 IC50 = 28800 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
339 4 1 5 3.6 CC(C)(C)C1=CC2=C(C=C1)OCC(O2)C(=O)NN=CC3=CC=CC=N3
CHEMBL1904956 apj_human Human Yes 4.5 IC50 = 28800 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
339 4 1 5 3.6 CC(C)(C)C1=CC2=C(C=C1)OCC(O2)C(=O)NN=CC3=CC=CC=N3
CHEMBL2158349 apj_human Human Yes 4.5 IC50 = 29000 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
408 6 0 10 3.3 C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)C(F)(F)F
CHEMBL2158349 apj_human Human Yes 4.5 IC50 = 29000 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
408 6 0 10 3.3 C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)C(F)(F)F
CHEMBL1382003 apj_human Human Yes 4.5 IC50 = 30900 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
440 6 0 6 5.6 CC1=C(C2=C(S1)N=C(N(C2=O)C3=CC=CC=C3)SCCN(C)C)C4=CC=C(C=C4)F
CHEMBL1382003 apj_human Human Yes 4.5 IC50 = 30900 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
440 6 0 6 5.6 CC1=C(C2=C(S1)N=C(N(C2=O)C3=CC=CC=C3)SCCN(C)C)C4=CC=C(C=C4)F
CHEMBL2158275 apj_human Human Yes 5.5 IC50 = 3110 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
399 6 0 9 2.6 CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)[N+](=O)[O-]
CHEMBL2158275 apj_human Human Yes 5.5 IC50 = 3110 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
399 6 0 9 2.6 CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)[N+](=O)[O-]
CHEMBL2158342 apj_human Human No 5.5 IC50 = 3210 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
466 6 0 10 2.0 CC1=NC(=NC=C1)S(=O)(=O)CC2=CC(=O)C(=CO2)OC(=O)C3=CC(=C(C=C3)Cl)[N+](=O)[O-]
CHEMBL2158342 apj_human Human No 5.5 IC50 = 3210 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
466 6 0 10 2.0 CC1=NC(=NC=C1)S(=O)(=O)CC2=CC(=O)C(=CO2)OC(=O)C3=CC(=C(C=C3)Cl)[N+](=O)[O-]
CHEMBL1599381 apj_human Human Yes 4.4 IC50 = 39900 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
488 8 0 10 2.4 CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)S(=O)(=O)N4CCCC4
CHEMBL1599381 apj_human Human Yes 4.4 IC50 = 39900 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
488 8 0 10 2.4 CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)S(=O)(=O)N4CCCC4
CHEMBL1717529 apj_human Human No 5.4 IC50 = 4120 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
277 3 2 4 4.7 CC(=C1C=CC=CC1=O)NNC2=NC3=CC=CC=C3C=C2
CHEMBL1892026 apj_human Human No 5.4 IC50 = 4120 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
277 3 2 4 4.7 CC(=C1C=CC=CC1=O)NNC2=NC3=CC=CC=C3C=C2
CHEMBL1717529 apj_human Human No 5.4 IC50 = 4120 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
277 3 2 4 4.7 CC(=C1C=CC=CC1=O)NNC2=NC3=CC=CC=C3C=C2
CHEMBL1892026 apj_human Human No 5.4 IC50 = 4120 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
277 3 2 4 4.7 CC(=C1C=CC=CC1=O)NNC2=NC3=CC=CC=C3C=C2
CHEMBL2158327 apj_human Human No 5.3 IC50 = 4530 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
452 6 0 7 4.8 C1=CC(=CC=C1SCC2=CC(=O)C(=CO2)OC(=O)C3=CC(=C(C=C3)Cl)[N+](=O)[O-])Cl
CHEMBL2158327 apj_human Human No 5.3 IC50 = 4530 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
452 6 0 7 4.8 C1=CC(=CC=C1SCC2=CC(=O)C(=CO2)OC(=O)C3=CC(=C(C=C3)Cl)[N+](=O)[O-])Cl
CHEMBL2158272 apj_human Human Yes 5.3 IC50 = 4700 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
413 6 0 9 3.0 CC1=C(C=C(C=C1)C(=O)OC2=COC(=CC2=O)CSC3=NC=CC(=N3)C)[N+](=O)[O-]
CHEMBL2158272 apj_human Human Yes 5.3 IC50 = 4700 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
413 6 0 9 3.0 CC1=C(C=C(C=C1)C(=O)OC2=COC(=CC2=O)CSC3=NC=CC(=N3)C)[N+](=O)[O-]
CHEMBL2158005 apj_human Human Yes 4.3 IC50 = 51000 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
420 6 0 9 2.8 C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=C(C=CC(=C3)[N+](=O)[O-])Cl
CHEMBL2158005 apj_human Human Yes 4.3 IC50 = 51000 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
420 6 0 9 2.8 C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=C(C=CC(=C3)[N+](=O)[O-])Cl
CHEMBL2158346 apj_human Human Yes 4.3 IC50 = 54500 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
375 6 0 7 3.0 C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)Cl
CHEMBL2158346 apj_human Human Yes 4.3 IC50 = 54500 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
375 6 0 7 3.0 C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)Cl
CHEMBL3417391 apj_human Human No 7.2 IC50 = 57 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1258 38 14 17 -2.0 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OCC3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)N
CHEMBL3417391 apj_human Human No 7.2 IC50 = 57 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1258 38 14 17 -2.0 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OCC3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)N
CHEMBL2158281 apj_human Human Yes 4.2 IC50 = 58800 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
434 6 0 9 3.2 CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=C(C=CC(=C3)Cl)[N+](=O)[O-]
CHEMBL2158281 apj_human Human Yes 4.2 IC50 = 58800 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
434 6 0 9 3.2 CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=C(C=CC(=C3)Cl)[N+](=O)[O-]
CHEMBL2158273 apj_human Human Yes 4.2 IC50 = 59200 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
399 6 0 9 2.6 CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL2158273 apj_human Human Yes 4.2 IC50 = 59200 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
399 6 0 9 2.6 CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL3417381 apj_human Human No 8.2 IC50 = 6.1 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=N2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417381 apj_human Human No 8.2 IC50 = 6.1 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=N2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417383 apj_human Human No 8.2 IC50 = 6.7 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1530 45 18 20 -4.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CCC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417383 apj_human Human No 8.2 IC50 = 6.7 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1530 45 18 20 -4.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CCC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL2158344 apj_human Human Yes 5.2 IC50 = 6200 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
420 6 0 9 2.8 C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC(=C(C=C3)Cl)[N+](=O)[O-]
CHEMBL2158344 apj_human Human Yes 5.2 IC50 = 6200 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
420 6 0 9 2.8 C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC(=C(C=C3)Cl)[N+](=O)[O-]
CHEMBL2158348 apj_human Human Yes 5.2 IC50 = 6590 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
365 6 0 8 2.1 C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)C#N
CHEMBL2158348 apj_human Human Yes 5.2 IC50 = 6590 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
365 6 0 8 2.1 C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)C#N
CHEMBL3417375 apj_human Human No 8.1 IC50 = 7.9 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1482 44 18 20 -5.4 CCCCC(C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3417375 apj_human Human No 8.1 IC50 = 7.9 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting methodDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting method
1482 44 18 20 -5.4 CCCCC(C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL2158347 apj_human Human Yes 6.2 IC50 = 700 Funct
Antagonist activity at APJ receptor assessed as inhibition of apelin13-induced cAMP accumulationAntagonist activity at APJ receptor assessed as inhibition of apelin13-induced cAMP accumulation
385 6 0 9 2.2 C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)[N+](=O)[O-]
CHEMBL2158347 apj_human Human Yes 6.2 IC50 = 700 Funct
Antagonist activity at APJ receptor assessed as inhibition of apelin13-induced cAMP accumulationAntagonist activity at APJ receptor assessed as inhibition of apelin13-induced cAMP accumulation
385 6 0 9 2.2 C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)[N+](=O)[O-]
CHEMBL1443778 apj_human Human Yes 5.1 IC50 = 7220 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
335 1 2 5 1.4 CN1C(=O)C(=C2CC(NN2)C3=CC=C(C=C3)Cl)C(=O)N(C1=O)C
CHEMBL1443778 apj_human Human Yes 5.1 IC50 = 7220 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
335 1 2 5 1.4 CN1C(=O)C(=C2CC(NN2)C3=CC=C(C=C3)Cl)C(=O)N(C1=O)C
CHEMBL2158266 apj_human Human Yes 4.1 IC50 = 72200 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
399 6 0 9 2.6 CC1=C(C=CC=C1[N+](=O)[O-])C(=O)OC2=COC(=CC2=O)CSC3=NC=CC=N3
CHEMBL2158266 apj_human Human Yes 4.1 IC50 = 72200 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
399 6 0 9 2.6 CC1=C(C=CC=C1[N+](=O)[O-])C(=O)OC2=COC(=CC2=O)CSC3=NC=CC=N3
CHEMBL2158345 apj_human Human Yes 5.1 IC50 = 7250 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
399 6 0 9 2.6 CC1=C(C=C(C=C1)C(=O)OC2=COC(=CC2=O)CSC3=NC=CC=N3)[N+](=O)[O-]
CHEMBL2158345 apj_human Human Yes 5.1 IC50 = 7250 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
399 6 0 9 2.6 CC1=C(C=C(C=C1)C(=O)OC2=COC(=CC2=O)CSC3=NC=CC=N3)[N+](=O)[O-]
CHEMBL1470363 apj_human Human Yes 4.1 IC50 = 74100 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
434 6 0 9 3.2 CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=C(C=CC(=C3)[N+](=O)[O-])Cl
CHEMBL1470363 apj_human Human Yes 4.1 IC50 = 74100 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
434 6 0 9 3.2 CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=C(C=CC(=C3)[N+](=O)[O-])Cl
CHEMBL1557707 apj_human Human Yes 4.1 IC50 = 75700 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
385 6 0 9 2.2 C1=CC(=CC(=C1)[N+](=O)[O-])C(=O)OC2=COC(=CC2=O)CSC3=NC=CC=N3
CHEMBL1557707 apj_human Human Yes 4.1 IC50 = 75700 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
385 6 0 9 2.2 C1=CC(=CC(=C1)[N+](=O)[O-])C(=O)OC2=COC(=CC2=O)CSC3=NC=CC=N3
CHEMBL1366012 apj_human Human Yes 5.1 IC50 = 7680 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
387 3 3 4 5.2 CC1=CC(=C(C=C1)O)NC(=S)NC(=O)C2=CC=C(O2)C3=CC=C(C=C3)Cl
CHEMBL1366012 apj_human Human Yes 5.1 IC50 = 7680 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
387 3 3 4 5.2 CC1=CC(=C(C=C1)O)NC(=S)NC(=O)C2=CC=C(O2)C3=CC=C(C=C3)Cl
CHEMBL2158325 apj_human Human No 5.1 IC50 = 8270 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
448 7 0 8 4.2 COC1=CC=C(C=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC(=C(C=C3)Cl)[N+](=O)[O-]
CHEMBL2158325 apj_human Human No 5.1 IC50 = 8270 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
448 7 0 8 4.2 COC1=CC=C(C=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC(=C(C=C3)Cl)[N+](=O)[O-]
CHEMBL2158276 apj_human Human Yes 5.1 IC50 = 8510 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
379 6 0 8 2.5 CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)C#N
CHEMBL2158276 apj_human Human Yes 5.1 IC50 = 8510 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
379 6 0 8 2.5 CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)C#N
CHEMBL1875956 apj_human Human Yes 5.0 IC50 = 9070 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
1131 16 13 24 0.7 CC=C(C)C(=O)OC1C(C2(C(CC1(C)C)C3=CCC4C5(CCC(C(C5CCC4(C3(CC2O)C)C)(C)CO)OC6C(C(C(C(O6)C(=O)O)OC7C(C(C(C(O7)CO)O)O)O)O)OC8C(C(C(C(O8)CO)O)O)O)C)CO)OC(=O)C
CHEMBL1875956 apj_human Human Yes 5.0 IC50 = 9070 Funct
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159]
1131 16 13 24 0.7 CC=C(C)C(=O)OC1C(C2(C(CC1(C)C)C3=CCC4C5(CCC(C(C5CCC4(C3(CC2O)C)C)(C)CO)OC6C(C(C(C(O6)C(=O)O)OC7C(C(C(C(O7)CO)O)O)O)O)OC8C(C(C(C(O8)CO)O)O)O)C)CO)OC(=O)C
CHEMBL2158329 apj_human Human No 5.0 IC50 = 9610 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
418 6 0 7 4.2 C1=CC=C(C=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC(=C(C=C3)Cl)[N+](=O)[O-]
CHEMBL2158329 apj_human Human No 5.0 IC50 = 9610 Funct
Antagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assayAntagonist activity at APJ receptor expressed in CHOK1 cells assessed as inhibition of apelin13-induced beta-arrestin recruitment after 90 mins by luminescence assay
418 6 0 7 4.2 C1=CC=C(C=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC(=C(C=C3)Cl)[N+](=O)[O-]
CHEMBL3417384 apj_human Human No 10.8 Ki = 0.0 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1622 47 18 21 -3.7 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OCC3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3417384 apj_human Human No 10.8 Ki = 0.0 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1622 47 18 21 -3.7 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OCC3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3809968 apj_human Human No 9.9 Ki = 0.1 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1691 47 20 22 -2.5 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(C)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3808761 apj_human Human No 9.9 Ki = 0.1 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1689 48 21 22 -2.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(CC2=CN=CN2)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)N5CCCC5C(=O)O)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3809767 apj_human Human No 9.7 Ki = 0.2 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
3951 123 59 54 -12.4 CC(C)CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)N1)NC(=O)C(CC(=O)N)NC(=O)C(CC2=CN=CN2)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCSC)NC(=O)C(C(C)O)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)N)NC(=O)C(C(C)C)NC(=O)C3CCCN3C(=O)C(CCCNC(=N)N)NC(=O)C4CCC(=O)N4)C(=O)NC(CCSC)C(=O)N5CCCC5C(=O)NC(CC(C)C)C(=O)NC(CC6=CN=CN6)C(=O)NC(CCCNC(=N)N)C(=O)NC(CO)C(=O)NC(C(C)C)C(=O)N7CCCC7C(=O)NC(CC8=CC=CC=C8)C(=O)N9CCCC9C(=O)O)CCCNC(=N)N)CCCNC(=N)N)CCC(=O)N
CHEMBL3417378 apj_human Human No 9.7 Ki = 0.2 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1530 44 18 20 -4.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)C)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417378 apj_human Human No 9.7 Ki = 0.2 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1530 44 18 20 -4.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)C)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3810388 apj_human Human No 9.6 Ki = 0.2 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1938 49 26 27 -5.2 CC(C)CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)N1)N)C(=O)NC(CCSC)C(=O)N2CCCC2C(=O)NC(CC(C)C)C(=O)NC(CC3=CN=CN3)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)C)C(=O)N4CCCC4C(=O)NC(CC5=CC=CC=C5)C(=O)N6CCCC6C(=O)O)CCCNC(=N)N)CCCNC(=N)N)CCC(=O)N
CHEMBL3417389 apj_human Human No 9.5 Ki = 0.3 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1530 44 18 20 -5.0 CCCCC(C(=O)N1CCCC1C(=O)NC(C)(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3809335 apj_human Human No 9.5 Ki = 0.3 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1940 61 28 27 -5.1 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CS)N
CHEMBL3417389 apj_human Human No 9.5 Ki = 0.3 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1530 44 18 20 -5.0 CCCCC(C(=O)N1CCCC1C(=O)NC(C)(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3809818 apj_human Human No 9.4 Ki = 0.4 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3809818 apj_human Human No 9.4 Ki = 0.4 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3809291 apj_human Human No 9.4 Ki = 0.4 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1691 48 21 23 -4.6 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CO)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417385 apj_human Human No 9.4 Ki = 0.4 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1620 46 18 21 -3.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)C(=O)C3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3417385 apj_human Human No 9.4 Ki = 0.4 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1620 46 18 21 -3.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)C(=O)C3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3417377 apj_human Human No 9.3 Ki = 0.5 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1546 45 18 21 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OC)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417377 apj_human Human No 9.3 Ki = 0.5 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1546 45 18 21 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OC)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3809537 apj_human Human No 9.3 Ki = 0.5 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1667 48 21 23 -5.8 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)N
CHEMBL3417390 apj_human Human No 9.2 Ki = 0.7 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1530 44 18 20 -5.0 CCCCC(C(=O)N1CCCC1C(=O)NC(C)(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417390 apj_human Human No 9.2 Ki = 0.7 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1530 44 18 20 -5.0 CCCCC(C(=O)N1CCCC1C(=O)NC(C)(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3184840 apj_human Human Yes 9.2 Ki = 0.7 Funct
Displacement of [125I]-[Nle75, Tyr77] Pyr1-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cell membranes after 1 hr by gamma-counting methodDisplacement of [125I]-[Nle75, Tyr77] Pyr1-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cell membranes after 1 hr by gamma-counting method
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417291 apj_human Human No 9.1 Ki = 0.8 Funct
Displacement of [125I]-[Nle75, Tyr77] Pyr1-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cell membranes after 1 hr by gamma-counting methodDisplacement of [125I]-[Nle75, Tyr77] Pyr1-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cell membranes after 1 hr by gamma-counting method
1516 44 18 20 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3809149 apj_human Human No 9.1 Ki = 0.8 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1675 47 20 22 -3.5 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3809739 apj_human Human Yes 9.0 Ki = 0.9 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1707 48 21 23 -3.6 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417379 apj_human Human No 9.0 Ki = 1 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=NC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3184840 apj_human Human Yes 9.0 Ki = 1 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417379 apj_human Human No 9.0 Ki = 1 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=NC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3184840 apj_human Human Yes 9.0 Ki = 1 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1534 44 18 21 -5.9 CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417386 apj_human Human No 8.9 Ki = 1.2 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1542 45 18 20 -4.5 CCCCC(C(=O)N1CCCC1C(=O)NC(CC=CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417386 apj_human Human No 8.9 Ki = 1.2 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1542 45 18 20 -4.5 CCCCC(C(=O)N1CCCC1C(=O)NC(CC=CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417380 apj_human Human No 8.9 Ki = 1.3 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CN=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417380 apj_human Human No 8.9 Ki = 1.3 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CN=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3414601 apj_human Human No 8.9 Ki = 1.4 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1528 42 18 20 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC2(CCC3=CC=CC=C32)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3414601 apj_human Human No 8.9 Ki = 1.4 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1528 42 18 20 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC2(CCC3=CC=CC=C32)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3808736 apj_human Human No 8.0 Ki = 11 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1681 49 22 23 -3.9 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)NC(C)C(=O)O)NC(=O)C4CCCN4C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3417387 apj_human Human No 8.0 Ki = 11 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1618 44 18 20 -3.3 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2C3=CC=CC=C3CC4=CC=CC=C24)C(=O)O)NC(=O)C5CCCN5C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC6=CN=CN6)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C7CCCN7C(=O)C(CCCN=C(N)N)NC(=O)C8CCC(=O)N8
CHEMBL3808736 apj_human Human No 8.0 Ki = 11 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1681 49 22 23 -3.9 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)NC(C)C(=O)O)NC(=O)C4CCCN4C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3417387 apj_human Human No 8.0 Ki = 11 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1618 44 18 20 -3.3 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2C3=CC=CC=C3CC4=CC=CC=C24)C(=O)O)NC(=O)C5CCCN5C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC6=CN=CN6)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C7CCCN7C(=O)C(CCCN=C(N)N)NC(=O)C8CCC(=O)N8
CHEMBL3417382 apj_human Human No 7.9 Ki = 11.4 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1502 43 18 20 -5.5 CCCCC(C(=O)N1CCCC1C(=O)NC(C2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417382 apj_human Human No 7.9 Ki = 11.4 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1502 43 18 20 -5.5 CCCCC(C(=O)N1CCCC1C(=O)NC(C2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3817879 apj_human Human No 5.9 Ki = 1300 Funct
Displacement of [125I]-apelin13 from human APJ receptor expressed in CHOK1 cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-apelin13 from human APJ receptor expressed in CHOK1 cell membranes after 2 hrs by scintillation counting
524 11 2 7 6.2 COC1=C(C(=CC=C1)OC)C2=CC(=NN2C3=CC=C(C=C3)F)C(=O)NC(CCC4CCCCC4)CC(=O)O
CHEMBL3817879 apj_human Human No 5.9 Ki = 1300 Funct
Displacement of [125I]-apelin13 from human APJ receptor expressed in CHOK1 cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-apelin13 from human APJ receptor expressed in CHOK1 cell membranes after 2 hrs by scintillation counting
524 11 2 7 6.2 COC1=C(C(=CC=C1)OC)C2=CC(=NN2C3=CC=C(C=C3)F)C(=O)NC(CCC4CCCCC4)CC(=O)O
CHEMBL3809035 apj_human Human No 7.9 Ki = 14 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1284 34 14 18 -2.7 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)N
CHEMBL3417376 apj_human Human No 7.8 Ki = 14.6 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1468 43 18 20 -5.8 CCCCC(C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3417376 apj_human Human No 7.8 Ki = 14.6 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1468 43 18 20 -5.8 CCCCC(C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3818506 apj_human Human No 5.9 Ki = 1400 Funct
Displacement of [125I]-apelin13 from human APJ receptor expressed in CHOK1 cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-apelin13 from human APJ receptor expressed in CHOK1 cell membranes after 2 hrs by scintillation counting
496 9 2 7 5.1 COC1=C(C(=CC=C1)OC)C2=CC(=NN2C3=CC=C(C=C3)F)C(=O)NC(CC(=O)O)C4CCCCC4
CHEMBL3818506 apj_human Human No 5.9 Ki = 1400 Funct
Displacement of [125I]-apelin13 from human APJ receptor expressed in CHOK1 cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-apelin13 from human APJ receptor expressed in CHOK1 cell membranes after 2 hrs by scintillation counting
496 9 2 7 5.1 COC1=C(C(=CC=C1)OC)C2=CC(=NN2C3=CC=C(C=C3)F)C(=O)NC(CC(=O)O)C4CCCCC4
CHEMBL3809972 apj_human Human No 6.8 Ki = 164 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1622 44 19 22 -2.4 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417291 apj_human Human No 8.7 Ki = 2.1 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1516 44 18 20 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417291 apj_human Human No 8.7 Ki = 2.1 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1516 44 18 20 -5.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417388 apj_human Human No 8.7 Ki = 2.2 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1572 44 18 21 -4.1 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CSC3=CC=CC=C32)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3417388 apj_human Human No 8.7 Ki = 2.2 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1572 44 18 21 -4.1 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CSC3=CC=CC=C32)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCCN6C(=O)C(CCCN=C(N)N)NC(=O)C7CCC(=O)N7
CHEMBL3809334 apj_human Human No 7.7 Ki = 20 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1665 46 21 23 -4.9 CC(C)C(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)N3CCCC3C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(CO)NC(=O)C(CC4=CN=CN4)NC(=O)C(C)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3808818 apj_human Human No 7.7 Ki = 20 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1679 47 21 23 -4.6 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3808449 apj_human Human No 7.7 Ki = 22 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1706 48 21 22 -4.2 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)N)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3810012 apj_human Human No 8.5 Ki = 3.4 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1647 45 21 22 -4.2 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(C)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3810012 apj_human Human No 8.5 Ki = 3.4 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1647 45 21 22 -4.2 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(C)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3818972 apj_human Human No 5.5 Ki = 3000 Funct
Displacement of [125I]-apelin13 from human APJ receptor expressed in CHOK1 cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-apelin13 from human APJ receptor expressed in CHOK1 cell membranes after 2 hrs by scintillation counting
518 11 2 7 5.1 COC1=C(C(=CC=C1)OC)C2=CC(=NN2C3=CC=C(C=C3)F)C(=O)NC(CCC4=CC=CC=C4)CC(=O)O
CHEMBL3818972 apj_human Human No 5.5 Ki = 3000 Funct
Displacement of [125I]-apelin13 from human APJ receptor expressed in CHOK1 cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-apelin13 from human APJ receptor expressed in CHOK1 cell membranes after 2 hrs by scintillation counting
518 11 2 7 5.1 COC1=C(C(=CC=C1)OC)C2=CC(=NN2C3=CC=C(C=C3)F)C(=O)NC(CCC4=CC=CC=C4)CC(=O)O
CHEMBL3810194 apj_human Human No 7.5 Ki = 35 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1641 46 20 22 -3.4 CC(C)CC(C(=O)NC(C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)N3CCCC3C(=O)O)NC(=O)C4CCCN4C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3809538 apj_human Human No 8.4 Ki = 4 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1681 49 22 23 -3.9 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3417381 apj_human Human No 8.3 Ki = 4.9 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=N2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417381 apj_human Human No 8.3 Ki = 4.9 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1517 44 18 21 -6.2 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=N2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417391 apj_human Human No 7.3 Ki = 46 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1258 38 14 17 -2.0 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OCC3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)N
CHEMBL3417391 apj_human Human No 7.3 Ki = 46 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1258 38 14 17 -2.0 CCCCC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)OCC3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC5=CN=CN5)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)N
CHEMBL3809707 apj_human Human No 7.3 Ki = 48 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1681 49 22 23 -3.9 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)NC(C)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CCCC3C(=O)O)NC(=O)C4CCCN4C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3809477 apj_human Human No 7.3 Ki = 49 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1631 46 21 23 -5.2 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C)C(=O)N3CCCC3C(=O)O)NC(=O)C4CCCN4C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3809477 apj_human Human No 7.3 Ki = 49 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1631 46 21 23 -5.2 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C)C(=O)N3CCCC3C(=O)O)NC(=O)C4CCCN4C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3417383 apj_human Human No 8.3 Ki = 5.4 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1530 45 18 20 -4.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CCC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417383 apj_human Human No 8.3 Ki = 5.4 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1530 45 18 20 -4.8 CCCCC(C(=O)N1CCCC1C(=O)NC(CCC2=CC=CC=C2)C(=O)O)NC(=O)C3CCCN3C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC4=CN=CN4)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3417375 apj_human Human No 8.2 Ki = 6.3 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1482 44 18 20 -5.4 CCCCC(C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3417375 apj_human Human No 8.2 Ki = 6.3 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1482 44 18 20 -5.4 CCCCC(C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3809136 apj_human Human No 8.2 Ki = 6.8 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1622 44 19 22 -2.4 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(C)NC(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6
CHEMBL3818101 apj_human Human No 6.2 Ki = 600 Funct
Displacement of [125I]-apelin13 from human APJ receptor expressed in CHOK1 cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-apelin13 from human APJ receptor expressed in CHOK1 cell membranes after 2 hrs by scintillation counting
470 10 2 7 4.5 CC(C)CC(CC(=O)O)NC(=O)C1=NN(C(=C1)C2=C(C=CC=C2OC)OC)C3=CC=C(C=C3)F
CHEMBL3818101 apj_human Human No 6.2 Ki = 600 Funct
Displacement of [125I]-apelin13 from human APJ receptor expressed in CHOK1 cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-apelin13 from human APJ receptor expressed in CHOK1 cell membranes after 2 hrs by scintillation counting
470 10 2 7 4.5 CC(C)CC(CC(=O)O)NC(=O)C1=NN(C(=C1)C2=C(C=CC=C2OC)OC)C3=CC=C(C=C3)F
CHEMBL3809768 apj_human Human No 8.1 Ki = 8.4 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1622 44 19 22 -2.4 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C6CCC(=O)N6
CHEMBL3809768 apj_human Human No 8.1 Ki = 8.4 Funct
Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting methodDisplacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting method
1622 44 19 22 -2.4 CC(C)CC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)O)NC(=O)C5CCCN5C(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C6CCC(=O)N6
CHEMBL3414600 apj_human Human No 8.0 Ki = 9.1 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1482 44 18 20 -5.4 CCCCC(C(=O)N1CCCC1C(=O)NC(C(C)CC)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
CHEMBL3414600 apj_human Human No 8.0 Ki = 9.1 Funct
Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysisDisplacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by Cheng-Prusoff equation analysis
1482 44 18 20 -5.4 CCCCC(C(=O)N1CCCC1C(=O)NC(C(C)CC)C(=O)O)NC(=O)C2CCCN2C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=CN=CN3)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)NC(=O)C5CCC(=O)N5
«

Versions

Package Name Version
Django 2.2.1
Python 3.6.7
debug_toolbar Debug Toolbar 1.11
polymorphic Polymorphic 2.0.3
rest_framework Django REST framework 3.9.3
rest_framework_swagger Rest_Framework_Swagger 2.2.0

Time

Resource usage

Resource Value
User CPU time 2007.995 msec
System CPU time 171.294 msec
Total CPU time 2179.289 msec
Elapsed time 2701.848 msec
Context switches 430 voluntary, 134 involuntary

Browser timing

Timing attribute Timeline Milliseconds since navigation start (+length)

Settings from protwis.settings

Setting Value
ABSOLUTE_URL_OVERRIDES {}
ADMINS []
ALLOWED_HOSTS ['*']
APPEND_SLASH True
AUTHENTICATION_BACKENDS ['django.contrib.auth.backends.ModelBackend']
AUTH_PASSWORD_VALIDATORS '********************'
AUTH_USER_MODEL 'auth.User'
BASE_DIR '/home/protwis/gpcrdb_test'
BUILD_CACHE_DIR '/home/protwis/gpcrdb_data/cache'
CACHES {'alignments': {'BACKEND': 'django.core.cache.backends.filebased.FileBasedCache', 'LOCATION': '/home/protwis/caches/test_alignment', 'OPTIONS': {'MAX_ENTRIES': 1000}}, 'default': {'BACKEND': 'django.core.cache.backends.filebased.FileBasedCache', 'LOCATION': '/home/protwis/caches/test/', 'OPTIONS': {'MAX_ENTRIES': 10000000}}}
CACHE_MIDDLEWARE_ALIAS 'default'
CACHE_MIDDLEWARE_KEY_PREFIX '********************'
CACHE_MIDDLEWARE_SECONDS 600
CSRF_COOKIE_AGE 31449600
CSRF_COOKIE_DOMAIN None
CSRF_COOKIE_HTTPONLY False
CSRF_COOKIE_NAME 'csrftoken'
CSRF_COOKIE_PATH '/'
CSRF_COOKIE_SAMESITE 'Lax'
CSRF_COOKIE_SECURE False
CSRF_FAILURE_VIEW 'django.views.csrf.csrf_failure'
CSRF_HEADER_NAME 'HTTP_X_CSRFTOKEN'
CSRF_TRUSTED_ORIGINS []
CSRF_USE_SESSIONS False
DATABASES {'default': {'ATOMIC_REQUESTS': False, 'AUTOCOMMIT': True, 'CONN_MAX_AGE': 0, 'ENGINE': 'django.db.backends.postgresql_psycopg2', 'HOST': 'localhost', 'NAME': 'protwis_202107', 'OPTIONS': {}, 'PASSWORD': '********************', 'PORT': '', 'TEST': {'CHARSET': None, 'COLLATION': None, 'MIRROR': None, 'NAME': None}, 'TIME_ZONE': None, 'USER': 'protwis'}}
DATABASE_ROUTERS []
DATA_DIR '/home/protwis/gpcrdb_data'
DATA_UPLOAD_MAX_MEMORY_SIZE 2621440
DATA_UPLOAD_MAX_NUMBER_FIELDS 1000
DATETIME_FORMAT 'N j, Y, P'
DATETIME_INPUT_FORMATS ['%Y-%m-%d %H:%M:%S', '%Y-%m-%d %H:%M:%S.%f', '%Y-%m-%d %H:%M', '%Y-%m-%d', '%m/%d/%Y %H:%M:%S', '%m/%d/%Y %H:%M:%S.%f', '%m/%d/%Y %H:%M', '%m/%d/%Y', '%m/%d/%y %H:%M:%S', '%m/%d/%y %H:%M:%S.%f', '%m/%d/%y %H:%M', '%m/%d/%y']
DATE_FORMAT 'N j, Y'
DATE_INPUT_FORMATS ['%Y-%m-%d', '%m/%d/%Y', '%m/%d/%y', '%b %d %Y', '%b %d, %Y', '%d %b %Y', '%d %b, %Y', '%B %d %Y', '%B %d, %Y', '%d %B %Y', '%d %B, %Y']
DEBUG True
DEBUG_PROPAGATE_EXCEPTIONS False
DEBUG_TOOLBAR_PATCH_SETTINGS False
DECIMAL_SEPARATOR '.'
DEFAULT_CHARSET 'utf-8'
DEFAULT_CONTENT_TYPE 'text/html'
DEFAULT_EXCEPTION_REPORTER_FILTER 'django.views.debug.SafeExceptionReporterFilter'
DEFAULT_FILE_STORAGE 'django.core.files.storage.FileSystemStorage'
DEFAULT_FROM_EMAIL 'webmaster@localhost'
DEFAULT_INDEX_TABLESPACE ''
DEFAULT_NUMBERING_SCHEME 'gpcrdb'
DEFAULT_PROTEIN_STATE 'inactive'
DEFAULT_SITE 'gpcr'
DEFAULT_TABLESPACE ''
DISALLOWED_USER_AGENTS []
DOCUMENTATION_URL 'https://docs.gpcrdb.org/'
EMAIL_BACKEND 'django.core.mail.backends.smtp.EmailBackend'
EMAIL_HOST 'localhost'
EMAIL_HOST_PASSWORD '********************'
EMAIL_HOST_USER ''
EMAIL_PORT 25
EMAIL_SSL_CERTFILE None
EMAIL_SSL_KEYFILE '********************'
EMAIL_SUBJECT_PREFIX '[Django] '
EMAIL_TIMEOUT None
EMAIL_USE_LOCALTIME False
EMAIL_USE_SSL False
EMAIL_USE_TLS False
FILE_CHARSET 'utf-8'
FILE_UPLOAD_DIRECTORY_PERMISSIONS None
FILE_UPLOAD_HANDLERS ['django.core.files.uploadhandler.MemoryFileUploadHandler', 'django.core.files.uploadhandler.TemporaryFileUploadHandler']
FILE_UPLOAD_MAX_MEMORY_SIZE 2621440
FILE_UPLOAD_PERMISSIONS None
FILE_UPLOAD_TEMP_DIR None
FIRST_DAY_OF_WEEK 0
FIXTURE_DIRS []
FORCE_SCRIPT_NAME None
FORMAT_MODULE_PATH None
FORM_RENDERER 'django.forms.renderers.DjangoTemplates'
GOOGLE_ANALYTICS_API '********************'
GOOGLE_ANALYTICS_KEY '********************'
IGNORABLE_404_URLS []
INSTALLED_APPS ('django.contrib.admin', 'django.contrib.auth', 'django.contrib.contenttypes', 'django.contrib.sessions', 'django.contrib.messages', 'django.contrib.staticfiles', 'django.contrib.humanize', 'debug_toolbar', 'rest_framework', 'rest_framework_swagger', 'polymorphic', 'common', 'api', 'news', 'pages', 'home', 'protein', 'family', 'residue', 'alignment', 'similaritysearch', 'similaritymatrix', 'structure', 'ligand', 'interaction', 'mutation', 'phylogenetic_trees', 'sitesearch', 'build_gpcr', 'construct', 'tools', 'drugs', 'signprot', 'signprot2', 'mutational_landscape', 'contactnetwork', 'seqsign', 'angles', 'hotspots')
INTERNAL_IPS '10.0.2.2'
LANGUAGES [('af', 'Afrikaans'), ('ar', 'Arabic'), ('ast', 'Asturian'), ('az', 'Azerbaijani'), ('bg', 'Bulgarian'), ('be', 'Belarusian'), ('bn', 'Bengali'), ('br', 'Breton'), ('bs', 'Bosnian'), ('ca', 'Catalan'), ('cs', 'Czech'), ('cy', 'Welsh'), ('da', 'Danish'), ('de', 'German'), ('dsb', 'Lower Sorbian'), ('el', 'Greek'), ('en', 'English'), ('en-au', 'Australian English'), ('en-gb', 'British English'), ('eo', 'Esperanto'), ('es', 'Spanish'), ('es-ar', 'Argentinian Spanish'), ('es-co', 'Colombian Spanish'), ('es-mx', 'Mexican Spanish'), ('es-ni', 'Nicaraguan Spanish'), ('es-ve', 'Venezuelan Spanish'), ('et', 'Estonian'), ('eu', 'Basque'), ('fa', 'Persian'), ('fi', 'Finnish'), ('fr', 'French'), ('fy', 'Frisian'), ('ga', 'Irish'), ('gd', 'Scottish Gaelic'), ('gl', 'Galician'), ('he', 'Hebrew'), ('hi', 'Hindi'), ('hr', 'Croatian'), ('hsb', 'Upper Sorbian'), ('hu', 'Hungarian'), ('hy', 'Armenian'), ('ia', 'Interlingua'), ('id', 'Indonesian'), ('io', 'Ido'), ('is', 'Icelandic'), ('it', 'Italian'), ('ja', 'Japanese'), ('ka', 'Georgian'), ('kab', 'Kabyle'), ('kk', 'Kazakh'), ('km', 'Khmer'), ('kn', 'Kannada'), ('ko', 'Korean'), ('lb', 'Luxembourgish'), ('lt', 'Lithuanian'), ('lv', 'Latvian'), ('mk', 'Macedonian'), ('ml', 'Malayalam'), ('mn', 'Mongolian'), ('mr', 'Marathi'), ('my', 'Burmese'), ('nb', 'Norwegian Bokmål'), ('ne', 'Nepali'), ('nl', 'Dutch'), ('nn', 'Norwegian Nynorsk'), ('os', 'Ossetic'), ('pa', 'Punjabi'), ('pl', 'Polish'), ('pt', 'Portuguese'), ('pt-br', 'Brazilian Portuguese'), ('ro', 'Romanian'), ('ru', 'Russian'), ('sk', 'Slovak'), ('sl', 'Slovenian'), ('sq', 'Albanian'), ('sr', 'Serbian'), ('sr-latn', 'Serbian Latin'), ('sv', 'Swedish'), ('sw', 'Swahili'), ('ta', 'Tamil'), ('te', 'Telugu'), ('th', 'Thai'), ('tr', 'Turkish'), ('tt', 'Tatar'), ('udm', 'Udmurt'), ('uk', 'Ukrainian'), ('ur', 'Urdu'), ('vi', 'Vietnamese'), ('zh-hans', 'Simplified Chinese'), ('zh-hant', 'Traditional Chinese')]
LANGUAGES_BIDI ['he', 'ar', 'fa', 'ur']
LANGUAGE_CODE 'en-us'
LANGUAGE_COOKIE_AGE None
LANGUAGE_COOKIE_DOMAIN None
LANGUAGE_COOKIE_NAME 'django_language'
LANGUAGE_COOKIE_PATH '/'
LOCALE_PATHS []
LOGGING {'disable_existing_loggers': False, 'formatters': {'verbose': {'datefmt': '%d/%b/%Y %H:%M:%S', 'format': '[%(asctime)s] %(levelname)s ' '[%(name)s:%(lineno)s] %(message)s'}, 'verbose_low': {'datefmt': '%d/%b/%Y %H:%M:%S', 'format': '[%(asctime)s] %(levelname)s ' '[%(name)s:%(lineno)s]'}}, 'handlers': {'build': {'class': 'logging.FileHandler', 'filename': 'logs/build.log', 'formatter': 'verbose', 'level': 'DEBUG'}, 'django': {'class': 'logging.FileHandler', 'filename': 'logs/django.log', 'formatter': 'verbose', 'level': 'WARNING'}, 'protwis': {'class': 'logging.FileHandler', 'filename': 'logs/protwis.log', 'formatter': 'verbose', 'level': 'DEBUG'}}, 'loggers': {'build': {'handlers': ['build'], 'level': 'DEBUG'}, 'django': {'handlers': ['django'], 'level': 'WARNING', 'propagate': True}, 'protwis': {'handlers': ['protwis'], 'level': 'DEBUG'}}, 'version': 1}
LOGGING_CONFIG 'logging.config.dictConfig'
LOGIN_REDIRECT_URL '/accounts/profile/'
LOGIN_URL '/accounts/login/'
LOGOUT_REDIRECT_URL None
MANAGERS []
MEDIA_ROOT '/protwis/media/protwis'
MEDIA_URL '/media/'
MESSAGE_STORAGE 'django.contrib.messages.storage.fallback.FallbackStorage'
MIDDLEWARE ('common.middleware.stats.StatsMiddleware', 'debug_toolbar.middleware.DebugToolbarMiddleware', 'django.contrib.sessions.middleware.SessionMiddleware', 'django.middleware.common.CommonMiddleware', 'django.middleware.csrf.CsrfViewMiddleware', 'django.contrib.auth.middleware.AuthenticationMiddleware', 'django.contrib.messages.middleware.MessageMiddleware', 'django.middleware.clickjacking.XFrameOptionsMiddleware')
MIGRATION_MODULES {}
MONTH_DAY_FORMAT 'F j'
NUMBER_GROUPING 0
PASSWORD_HASHERS '********************'
PASSWORD_RESET_TIMEOUT_DAYS '********************'
PREPEND_WWW False
REFERENCE_POSITIONS {'D1S1': 'D1S1x50', 'D1S2': 'D1S2x50', 'D1T1': 'D1T1x50', 'D1e1': 'D1e1x50', 'ECL1': '23x50', 'ECL2': '45x50', 'H8': '8x50', 'ICL1': '12x50', 'ICL2': '34x50', 'TM1': '1x50', 'TM2': '2x50', 'TM3': '3x50', 'TM4': '4x50', 'TM5': '5x50', 'TM6': '6x50', 'TM7': '7x50'}
ROOT_URLCONF 'protwis.urls'
SECRET_KEY '********************'
SECURE_BROWSER_XSS_FILTER False
SECURE_CONTENT_TYPE_NOSNIFF False
SECURE_HSTS_INCLUDE_SUBDOMAINS False
SECURE_HSTS_PRELOAD False
SECURE_HSTS_SECONDS 0
SECURE_PROXY_SSL_HEADER None
SECURE_REDIRECT_EXEMPT []
SECURE_SSL_HOST None
SECURE_SSL_REDIRECT False
SERVER_EMAIL 'root@localhost'
SESSION_CACHE_ALIAS 'default'
SESSION_COOKIE_AGE 86400
SESSION_COOKIE_DOMAIN None
SESSION_COOKIE_HTTPONLY True
SESSION_COOKIE_NAME 'sessionid'
SESSION_COOKIE_PATH '/'
SESSION_COOKIE_SAMESITE 'Lax'
SESSION_COOKIE_SECURE False
SESSION_ENGINE 'django.contrib.sessions.backends.db'
SESSION_EXPIRE_AT_BROWSER_CLOSE False
SESSION_FILE_PATH None
SESSION_SAVE_EVERY_REQUEST False
SESSION_SERIALIZER 'django.contrib.sessions.serializers.PickleSerializer'
SETTINGS_MODULE 'protwis.settings'
SHORT_DATETIME_FORMAT 'm/d/Y P'
SHORT_DATE_FORMAT 'm/d/Y'
SIGNING_BACKEND 'django.core.signing.TimestampSigner'
SILENCED_SYSTEM_CHECKS []
SITE_NAME 'gpcr'
SITE_TITLE 'GPCRdb'
STATICFILES_DIRS ('/home/protwis/gpcrdb_test/static',)
STATICFILES_FINDERS ['django.contrib.staticfiles.finders.FileSystemFinder', 'django.contrib.staticfiles.finders.AppDirectoriesFinder']
STATICFILES_STORAGE 'django.contrib.staticfiles.storage.StaticFilesStorage'
STATIC_ROOT '/home/protwis/static_test/'
STATIC_URL '/static/'
SWAGGER_SETTINGS {'USE_SESSION_AUTH': False}
TEMPLATES [{'APP_DIRS': True, 'BACKEND': 'django.template.backends.django.DjangoTemplates', 'DIRS': [], 'OPTIONS': {'context_processors': ['django.contrib.auth.context_processors.auth', 'django.template.context_processors.debug', 'django.template.context_processors.i18n', 'django.template.context_processors.media', 'django.template.context_processors.static', 'django.template.context_processors.tz', 'django.contrib.messages.context_processors.messages', 'protwis.context_processors.current_site', 'protwis.context_processors.canonical_tag', 'protwis.context_processors.documentation_url', 'protwis.context_processors.google_analytics', 'protwis.context_processors.site_title'], 'debug': True}}]
TEST_NON_SERIALIZED_APPS []
TEST_RUNNER 'django.test.runner.DiscoverRunner'
THOUSAND_SEPARATOR ','
TIME_FORMAT 'P'
TIME_INPUT_FORMATS ['%H:%M:%S', '%H:%M:%S.%f', '%H:%M']
TIME_ZONE 'Europe/Copenhagen'
USE_I18N True
USE_L10N True
USE_THOUSAND_SEPARATOR False
USE_TZ True
USE_X_FORWARDED_HOST False
USE_X_FORWARDED_PORT False
WSGI_APPLICATION None
X_FRAME_OPTIONS 'SAMEORIGIN'
YEAR_MONTH_FORMAT 'F Y'

Headers

Request headers

Key Value
Accept text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8
Accept-Encoding br,gzip
Accept-Language en-US,en;q=0.5
Connection close
Host test.gpcrdb.org
User-Agent CCBot/2.0 (https://commoncrawl.org/faq/)
X-Forwarded-For 35.168.110.128
X-Forwarded-Proto https
X-Real-Ip 35.168.110.128

Response headers

Key Value
Content-Length 713892
Content-Type text/html; charset=utf-8
Vary Cookie
X-Frame-Options SAMEORIGIN

WSGI environ

Since the WSGI environ inherits the environment of the server, only a significant subset is shown below.

Key Value
PATH_INFO /ligand/target/all/001_002_002_001/
QUERY_STRING
REMOTE_ADDR
REQUEST_METHOD GET
SCRIPT_NAME
SERVER_NAME test.gpcrdb.org
SERVER_PORT 443
SERVER_PROTOCOL HTTP/1.0
SERVER_SOFTWARE gunicorn/19.9.0

Request

View information

View function Arguments Keyword arguments URL name
ligand.views.TargetDetails () {'slug': '001_002_002_001'} ligand_target_detail

No cookies

No session data

No GET data

No POST data

SQL queries from 1 connection

  •   default 572.21 ms (439 queries including 437 similar and 437 duplicates )
  Query Timeline Time (ms) Action
  +
SELECT ••• "ligand_assayexperiment"."id", "ligand_assayexperiment"."ligand_id", "ligand_assayexperiment"."protein_id", "ligand_assayexperiment"."assay_id", "ligand_assayexperiment"."assay_type", "ligand_assayexperiment"."assay_description", "ligand_assayexperiment"."pchembl_value", "ligand_assayexperiment"."published_value", "ligand_assayexperiment"."published_relation", "ligand_assayexperiment"."published_type", "ligand_assayexperiment"."published_units", "ligand_assayexperiment"."standard_value", "ligand_assayexperiment"."standard_relation", "ligand_assayexperiment"."standard_type", "ligand_assayexperiment"."standard_units", "ligand_assayexperiment"."publication_id", "ligand_assayexperiment"."chembl", "ligand_assayexperiment"."smiles", "ligand_assayexperiment"."activity", "ligand_assayexperiment"."document_chembl_id", "ligand_assayexperiment"."cell_line" FROM "ligand_assayexperiment" INNER JOIN "ligand" ON ("ligand_assayexperiment"."ligand_id" = "ligand"."id") INNER JOIN "ligand_properities" ON ("ligand"."properities_id" = "ligand_properities"."id") INNER JOIN "ligand_properities_web_links" ON ("ligand_properities"."id" = "ligand_properities_web_links"."ligandproperities_id") INNER JOIN "web_link" ON ("ligand_properities_web_links"."weblink_id" = "web_link"."id") INNER JOIN "web_resource" ON ("web_link"."web_resource_id" = "web_resource"."id") INNER JOIN "protein" ON ("ligand_assayexperiment"."protein_id" = "protein"."id") INNER JOIN "protein_family" ON ("protein"."family_id" = "protein_family"."id") WHERE ("web_resource"."slug" = 'chembl_ligand' AND "protein_family"."slug" = '001_002_002_001')
35.213567451848675%
201.50

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(334)
  if not ps:
  +
SELECT ••• "ligand_assayexperiment"."standard_type", "ligand_assayexperiment"."standard_relation", "ligand_assayexperiment"."standard_value", "ligand_assayexperiment"."assay_description", "ligand_assayexperiment"."assay_type", "ligand_assayexperiment"."pchembl_value", "ligand_assayexperiment"."ligand_id", "ligand"."properities_id", "web_link"."index", "species"."common_name", "protein"."entry_name", "ligand_properities"."mw", "ligand_properities"."logp", "ligand_properities"."rotatable_bonds", "ligand_properities"."smiles", "ligand_properities"."hdon", "ligand_properities"."hacc", "ligand_assayexperiment"."protein_id", COUNT(DISTINCT "ligand_assayexperiment"."protein_id") AS "num_targets" FROM "ligand_assayexperiment" INNER JOIN "ligand" ON ("ligand_assayexperiment"."ligand_id" = "ligand"."id") INNER JOIN "ligand_properities" ON ("ligand"."properities_id" = "ligand_properities"."id") INNER JOIN "ligand_properities_web_links" ON ("ligand_properities"."id" = "ligand_properities_web_links"."ligandproperities_id") INNER JOIN "web_link" ON ("ligand_properities_web_links"."weblink_id" = "web_link"."id") INNER JOIN "web_resource" ON ("web_link"."web_resource_id" = "web_resource"."id") INNER JOIN "protein" ON ("ligand_assayexperiment"."protein_id" = "protein"."id") INNER JOIN "protein_family" ON ("protein"."family_id" = "protein_family"."id") INNER JOIN "species" ON ("protein"."species_id" = "species"."id") WHERE ("web_resource"."slug" = 'chembl_ligand' AND "protein_family"."slug" = '001_002_002_001') GROUP BY "ligand_assayexperiment"."standard_type", "ligand_assayexperiment"."standard_relation", "ligand_assayexperiment"."standard_value", "ligand_assayexperiment"."assay_description", "ligand_assayexperiment"."assay_type", "ligand_assayexperiment"."pchembl_value", "ligand_assayexperiment"."ligand_id", "ligand"."properities_id", "web_link"."index", "species"."common_name", "protein"."entry_name", "ligand_properities"."mw", "ligand_properities"."logp", "ligand_properities"."rotatable_bonds", "ligand_properities"."smiles", "ligand_properities"."hdon", "ligand_properities"."hacc", "ligand_assayexperiment"."protein_id"
2.5202100966734693%
14.42

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(357)
  for record in ps:
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 2725 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 22 times.
0.368160837453407%
2.11

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 2725 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 22 times.
0.09495682985019405%
0.54

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 11853 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.3947854158975816%
2.26

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 11853 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.08766527863308832%
0.50

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 108367 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.0897485789808328%
0.51

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 108367 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.08566531029925359%
0.49

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 108182 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.26107919957934%
1.49

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 108182 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.08641529842444161%
0.49

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 108504 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.27787060038216066%
1.59

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 108504 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.08633196641053184%
0.49

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 107619 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.08895692484868989%
0.51

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 107619 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.08487365616711069%
0.49

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 107475 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 14 times.
0.08666529446617095%
0.50

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 107475 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 14 times.
0.08924858689737412%
0.51

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 2725 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 22 times.
0.0869152905079003%
0.50

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 2725 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 22 times.
0.08674862648008073%
0.50

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 39929 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.2668291085391148%
1.53

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 39929 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.08487365616711069%
0.49

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 15214 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 9 times.
0.08724861856353941%
0.50

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 15214 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 9 times.
0.08529031623665959%
0.49

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 107714 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.09495682985019405%
0.54

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 107714 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.08624863439662205%
0.49

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 39929 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.08466532613233624%
0.48

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 39929 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.08437366408365202%
0.48

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 2725 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 22 times.
0.08512365220884002%
0.49

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 2725 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 22 times.
0.08574864231316337%
0.49

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 107116 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.08883192682782523%
0.51

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 107116 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.08433199807669711%
0.48

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 450 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 2 times.
0.08999857502256214%
0.51

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 450 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 2 times.
0.08720695255658452%
0.50

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 11853 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.08466532613233624%
0.48

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 11853 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.08437366408365202%
0.48

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 2725 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 22 times.
0.08499865418797536%
0.49

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 102314 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 2 times.
0.26203751773930245%
1.50

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 107475 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 14 times.
0.08529031623665959%
0.49

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 4834 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.0872902845704943%
0.50

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 102314 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 2 times.
0.08454032811147157%
0.48

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 107475 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 14 times.
0.08408200203496778%
0.48

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 4834 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.08445699609756178%
0.48

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 108041 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.08749861460526875%
0.50

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 108331 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
0.08799860668872743%
0.50

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 108504 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  437 similar queries.   Duplicated 8 times.
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