Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Unit Assay Type Assay Description Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles
CHEMBL267388 fpr1_human Human No 9.0 EC50 = 1 Funct
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
563 14 5 6 3.5 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)NC2=CC=C(C=C2)Cl
CHEMBL7753 fpr1_human Human No 9.0 EC50 = 1 Funct
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
559 15 5 7 2.9 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)NC2=CC=C(C=C2)OC
CHEMBL267179 fpr1_human Human Yes 8.0 EC50 = 10 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
None None None CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC=O
CHEMBL267179 fpr1_human Human Yes 8.0 EC50 = 10 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
None None None CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC=O
CHEMBL562456 fpr1_human Human No 5.0 EC50 = 10500 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
408 6 1 6 2.4 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)[N+](=O)[O-]
CHEMBL2391281 fpr1_human Human No 5.0 EC50 = 10500 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
447 5 1 3 3.9 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)Cl)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL562456 fpr1_human Human No 5.0 EC50 = 10500 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
408 6 1 6 2.4 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)[N+](=O)[O-]
CHEMBL2391257 fpr1_human Human No 5.0 EC50 = 10800 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
510 7 1 4 5.4 COC1=CC=CC(=C1)CC2=CC(=NN(C2=O)CC(=O)NC3=CC=C(C=C3)Br)C4CCCCC4
CHEMBL562910 fpr1_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
393 7 1 5 2.6 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)OC
CHEMBL562910 fpr1_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
393 7 1 5 2.6 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)OC
CHEMBL562910 fpr1_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
393 7 1 5 2.6 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)OC
CHEMBL562910 fpr1_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
393 7 1 5 2.6 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)OC
CHEMBL2391452 fpr1_human Human No 5.0 EC50 = 11200 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
428 5 1 4 3.0 CC1=NN(C(=O)C(=C1)C2=CC=C(C=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL551590 fpr1_human Human No 5.0 EC50 = 11300 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
456 7 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CCC(=O)NC3=CC=C(C=C3)Br
CHEMBL551590 fpr1_human Human No 5.0 EC50 = 11300 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
456 7 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CCC(=O)NC3=CC=C(C=C3)Br
CHEMBL551590 fpr1_human Human No 5.0 EC50 = 11300 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
456 7 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CCC(=O)NC3=CC=C(C=C3)Br
CHEMBL551590 fpr1_human Human No 5.0 EC50 = 11300 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
456 7 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CCC(=O)NC3=CC=C(C=C3)Br
CHEMBL2391449 fpr1_human Human No 4.9 EC50 = 12800 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
443 6 2 5 3.1 CC1=NN(C(=O)C(=C1)NC2=CC=C(C=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL2391447 fpr1_human Human No 4.9 EC50 = 13500 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
485 7 2 6 3.5 CC1=NN(C(=O)C(=C1C(=O)C)NC2=CC=C(C=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL2391438 fpr1_human Human No 4.9 EC50 = 13800 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
462 5 1 3 4.6 CC1=NN(C(=O)C(=C1)CC2=CC=CC3=CC=CC=C32)CC(=O)NC4=CC=C(C=C4)Br
CHEMBL554291 fpr1_human Human No 4.8 EC50 = 15500 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
423 8 1 6 2.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC(=C(C=C3)OC)OC
CHEMBL554291 fpr1_human Human No 4.8 EC50 = 15500 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
423 8 1 6 2.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC(=C(C=C3)OC)OC
CHEMBL1770476 fpr1_human Human No 5.8 EC50 = 1584.9 Funct
Agonist activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assayAgonist activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay
425 8 2 6 3.7 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CCSC)C3=NC4=C(N3)C=NC=C4
CHEMBL1770476 fpr1_human Human No 5.8 EC50 = 1584.9 Funct
Agonist activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assayAgonist activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay
425 8 2 6 3.7 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CCSC)C3=NC4=C(N3)C=NC=C4
CHEMBL539401 fpr1_human Human No 5.8 EC50 = 1600 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
377 6 1 4 3.0 CC1=CC=C(C=C1)NC(=O)CN2C(=O)C(=CC(=N2)C)CC3=CC(=CC=C3)OC
CHEMBL539401 fpr1_human Human No 5.8 EC50 = 1600 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
377 6 1 4 3.0 CC1=CC=C(C=C1)NC(=O)CN2C(=O)C(=CC(=N2)C)CC3=CC(=CC=C3)OC
CHEMBL539401 fpr1_human Human No 5.8 EC50 = 1600 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
377 6 1 4 3.0 CC1=CC=C(C=C1)NC(=O)CN2C(=O)C(=CC(=N2)C)CC3=CC(=CC=C3)OC
CHEMBL539401 fpr1_human Human No 5.8 EC50 = 1600 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
377 6 1 4 3.0 CC1=CC=C(C=C1)NC(=O)CN2C(=O)C(=CC(=N2)C)CC3=CC(=CC=C3)OC
CHEMBL266802 fpr1_human Human No 8.7 EC50 = 2 Funct
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
543 14 5 6 3.3 CC1=CC=C(C=C1)NC(=O)NC(CCSC)C(=O)NC(CC(C)C)C(=O)NC(CC2=CC=CC=C2)C(=O)O
CHEMBL267179 fpr1_human Human Yes 7.7 EC50 = 20 Funct
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
None None None CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC=O
CHEMBL549570 fpr1_human Human No 4.7 EC50 = 21700 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
431 6 1 7 3.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL549570 fpr1_human Human No 4.7 EC50 = 21700 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
431 6 1 7 3.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL549570 fpr1_human Human No 4.7 EC50 = 21700 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
431 6 1 7 3.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL549570 fpr1_human Human No 4.7 EC50 = 21700 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
431 6 1 7 3.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL556485 fpr1_human Human No 5.6 EC50 = 2300 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
407 6 1 6 2.4 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC4=C(C=C3)OCO4
CHEMBL556485 fpr1_human Human No 5.6 EC50 = 2300 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
407 6 1 6 2.4 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC4=C(C=C3)OCO4
CHEMBL3588871 fpr1_human Human No 6.6 EC50 = 260 Funct
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilizationAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization
556 10 4 5 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=NC=C(C=C5)OC
CHEMBL556625 fpr1_human Human No 5.6 EC50 = 2600 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
398 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Cl
CHEMBL551589 fpr1_human Human No 5.6 EC50 = 2600 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL551589 fpr1_human Human No 5.6 EC50 = 2600 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL556625 fpr1_human Human No 5.6 EC50 = 2600 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
398 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Cl
CHEMBL551589 fpr1_human Human No 5.6 EC50 = 2600 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL551589 fpr1_human Human No 5.6 EC50 = 2600 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL560780 fpr1_human Human No 5.6 EC50 = 2800 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
489 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)I
CHEMBL560780 fpr1_human Human No 5.6 EC50 = 2800 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
489 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)I
CHEMBL2391440 fpr1_human Human No 4.5 EC50 = 29300 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
455 6 2 4 2.2 CC1=NN(C(=O)C(=C1)CC2=CC=C(C=C2)C(=O)N)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL265408 fpr1_human Human No 6.5 EC50 = 300 Funct
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
509 16 5 6 2.6 CCCCNC(=O)NC(CCSC)C(=O)NC(CC(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)O
CHEMBL2391446 fpr1_human Human No 5.5 EC50 = 3000 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
456 6 1 5 2.9 CC1=NN(C(=O)C(=C1)C(=O)C2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL7306 fpr1_human Human No 5.5 EC50 = 3000 Funct
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
453 13 5 6 0.9 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)N
CHEMBL564392 fpr1_human Human No 5.5 EC50 = 3200 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
456 6 1 4 3.7 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)C(C)C(=O)NC3=CC=C(C=C3)Br
CHEMBL561375 fpr1_human Human No 5.5 EC50 = 3200 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
363 6 1 4 2.6 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=CC=C3
CHEMBL560780 fpr1_human Human No 5.5 EC50 = 3200 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
489 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)I
CHEMBL561375 fpr1_human Human No 5.5 EC50 = 3200 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
363 6 1 4 2.6 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=CC=C3
CHEMBL560780 fpr1_human Human No 5.5 EC50 = 3200 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
489 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)I
CHEMBL564392 fpr1_human Human No 5.5 EC50 = 3200 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
456 6 1 4 3.7 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)C(C)C(=O)NC3=CC=C(C=C3)Br
CHEMBL561375 fpr1_human Human No 5.5 EC50 = 3200 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
363 6 1 4 2.6 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=CC=C3
CHEMBL560780 fpr1_human Human No 5.5 EC50 = 3200 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
489 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)I
CHEMBL561375 fpr1_human Human No 5.5 EC50 = 3200 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
363 6 1 4 2.6 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=CC=C3
CHEMBL560780 fpr1_human Human No 5.5 EC50 = 3200 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
489 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)I
CHEMBL551589 fpr1_human Human No 5.5 EC50 = 3400 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL551589 fpr1_human Human No 5.5 EC50 = 3400 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL556485 fpr1_human Human No 5.4 EC50 = 3600 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
407 6 1 6 2.4 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC4=C(C=C3)OCO4
CHEMBL554291 fpr1_human Human No 5.4 EC50 = 3600 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
423 8 1 6 2.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC(=C(C=C3)OC)OC
CHEMBL556485 fpr1_human Human No 5.4 EC50 = 3600 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
407 6 1 6 2.4 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC4=C(C=C3)OCO4
CHEMBL554291 fpr1_human Human No 5.4 EC50 = 3600 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
423 8 1 6 2.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC(=C(C=C3)OC)OC
CHEMBL556485 fpr1_human Human No 5.4 EC50 = 3600 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
407 6 1 6 2.4 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC4=C(C=C3)OCO4
CHEMBL554291 fpr1_human Human No 5.4 EC50 = 3600 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
423 8 1 6 2.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC(=C(C=C3)OC)OC
CHEMBL556485 fpr1_human Human No 5.4 EC50 = 3600 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
407 6 1 6 2.4 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC4=C(C=C3)OCO4
CHEMBL554291 fpr1_human Human No 5.4 EC50 = 3600 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
423 8 1 6 2.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC(=C(C=C3)OC)OC
CHEMBL552396 fpr1_human Human No 5.4 EC50 = 3900 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
381 6 1 5 2.7 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)F
CHEMBL552396 fpr1_human Human No 5.4 EC50 = 3900 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
381 6 1 5 2.7 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)F
CHEMBL552396 fpr1_human Human No 5.4 EC50 = 3900 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
381 6 1 5 2.7 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)F
CHEMBL552396 fpr1_human Human No 5.4 EC50 = 3900 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
381 6 1 5 2.7 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)F
CHEMBL7520 fpr1_human Human No 7.4 EC50 = 40 Funct
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
529 14 5 6 2.9 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)NC2=CC=CC=C2
CHEMBL2391255 fpr1_human Human No 5.4 EC50 = 4200 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
503 7 1 4 3.7 CCC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)I
CHEMBL3588871 fpr1_human Human No 6.4 EC50 = 430 Funct
Agonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
556 10 4 5 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=NC=C(C=C5)OC
CHEMBL3588871 fpr1_human Human No 6.4 EC50 = 430 Funct
Agonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
556 10 4 5 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=NC=C(C=C5)OC
CHEMBL562380 fpr1_human Human No 5.4 EC50 = 4300 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC=C(C=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL562380 fpr1_human Human No 5.4 EC50 = 4300 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC=C(C=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL562380 fpr1_human Human No 5.4 EC50 = 4300 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC=C(C=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL562380 fpr1_human Human No 5.4 EC50 = 4300 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC=C(C=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL2391256 fpr1_human Human No 5.4 EC50 = 4500 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
470 7 1 4 4.3 CC(C)C1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL2391286 fpr1_human Human No 5.4 EC50 = 4500 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
418 5 1 4 3.0 CC1=NN(C(=O)C(=C1)CC2=CSC=C2)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL2391277 fpr1_human Human No 5.3 EC50 = 5500 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
412 5 1 3 3.3 CC1=NN(C(=O)C(=C1)CC2=CC=CC=C2)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL549570 fpr1_human Human No 5.2 EC50 = 5700 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
431 6 1 7 3.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL549570 fpr1_human Human No 5.2 EC50 = 5700 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
431 6 1 7 3.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL2391285 fpr1_human Human No 5.2 EC50 = 5800 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
402 5 1 4 2.4 CC1=NN(C(=O)C(=C1)CC2=COC=C2)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL2391254 fpr1_human Human No 5.2 EC50 = 6100 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
428 6 1 4 3.0 COC1=CC=CC(=C1)CC2=CC=NN(C2=O)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL2391280 fpr1_human Human No 5.2 EC50 = 6600 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
430 5 1 4 3.4 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)F)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL556625 fpr1_human Human No 5.2 EC50 = 6700 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
398 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Cl
CHEMBL556625 fpr1_human Human No 5.2 EC50 = 6700 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
398 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Cl
CHEMBL556625 fpr1_human Human No 5.2 EC50 = 6700 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
398 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Cl
CHEMBL556625 fpr1_human Human No 5.2 EC50 = 6700 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
398 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Cl
CHEMBL2391279 fpr1_human Human No 5.2 EC50 = 6900 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
377 5 1 5 2.4 CC1=NN(C(=O)C(=C1)CC2=CC=CC=C2)CC(=O)NC3=CC4=C(C=C3)OCO4
CHEMBL539401 fpr1_human Human No 5.1 EC50 = 7200 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
377 6 1 4 3.0 CC1=CC=C(C=C1)NC(=O)CN2C(=O)C(=CC(=N2)C)CC3=CC(=CC=C3)OC
CHEMBL539401 fpr1_human Human No 5.1 EC50 = 7200 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
377 6 1 4 3.0 CC1=CC=C(C=C1)NC(=O)CN2C(=O)C(=CC(=N2)C)CC3=CC(=CC=C3)OC
CHEMBL552396 fpr1_human Human No 5.1 EC50 = 7600 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
381 6 1 5 2.7 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)F
CHEMBL2391442 fpr1_human Human No 5.1 EC50 = 7600 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
519 7 1 5 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC(=C2)OC)OC)CC(=O)NC3=CC=C(C=C3)I
CHEMBL552396 fpr1_human Human No 5.1 EC50 = 7600 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
381 6 1 5 2.7 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)F
CHEMBL562910 fpr1_human Human No 5.1 EC50 = 7700 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
393 7 1 5 2.6 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)OC
CHEMBL562910 fpr1_human Human No 5.1 EC50 = 7700 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
393 7 1 5 2.6 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)OC
CHEMBL564392 fpr1_human Human No 6.1 EC50 = 800 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
456 6 1 4 3.7 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)C(C)C(=O)NC3=CC=C(C=C3)Br
CHEMBL564392 fpr1_human Human No 6.1 EC50 = 800 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
456 6 1 4 3.7 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)C(C)C(=O)NC3=CC=C(C=C3)Br
CHEMBL564392 fpr1_human Human No 6.1 EC50 = 800 Funct
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
456 6 1 4 3.7 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)C(C)C(=O)NC3=CC=C(C=C3)Br
CHEMBL564392 fpr1_human Human No 6.1 EC50 = 800 Funct
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
456 6 1 4 3.7 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)C(C)C(=O)NC3=CC=C(C=C3)Br
CHEMBL2391448 fpr1_human Human No 5.1 EC50 = 8100 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
337 3 2 4 0.9 CC1=NN(C(=O)C(=C1)N)CC(=O)NC2=CC=C(C=C2)Br
CHEMBL2391437 fpr1_human Human No 5.1 EC50 = 8100 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
418 5 1 4 3.0 CC1=NN(C(=O)C(=C1)CC2=CC=CS2)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL6997 fpr1_human Human No 6.1 EC50 = 900 Funct
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
543 14 5 6 3.3 CC1=CC(=CC=C1)NC(=O)NC(CCSC)C(=O)NC(CC(C)C)C(=O)NC(CC2=CC=CC=C2)C(=O)O
CHEMBL2391258 fpr1_human Human No 5.1 EC50 = 9000 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
504 7 1 4 4.9 COC1=CC=CC(=C1)CC2=CC(=NN(C2=O)CC(=O)NC3=CC=C(C=C3)Br)C4=CC=CC=C4
CHEMBL2391450 fpr1_human Human No 5.0 EC50 = 9300 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
471 6 2 5 2.4 CC1=NN(C(=O)C(=C1)NC(=O)C2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL2391439 fpr1_human Human No 5.0 EC50 = 9300 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
413 5 1 4 2.2 CC1=NN(C(=O)C(=C1)CC2=CN=CC=C2)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL3590073 fpr1_human Human No 6.0 EC50 = 950 Funct
Agonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
526 9 4 4 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=CC=N5
CHEMBL3590073 fpr1_human Human No 6.0 EC50 = 950 Funct
Agonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
526 9 4 4 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=CC=N5
CHEMBL2391443 fpr1_human Human No 5.0 EC50 = 9500 Funct
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
494 5 1 3 3.9 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)Cl)CC(=O)NC3=CC=C(C=C3)I
CHEMBL551590 fpr1_human Human No 5.0 EC50 = 9700 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
456 7 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CCC(=O)NC3=CC=C(C=C3)Br
CHEMBL551590 fpr1_human Human No 5.0 EC50 = 9700 Funct
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
456 7 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CCC(=O)NC3=CC=C(C=C3)Br
CHEMBL1770298 fpr1_human Human Yes 7.0 IC50 = 100 Funct
Displacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation countingDisplacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation counting
394 5 3 4 4.8 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=C(S2)C)NC(=O)C3=CC=CC=C3O
CHEMBL6450 fpr1_human Human No 7.0 IC50 = 100 Funct
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
729 20 7 7 3.8 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)N
CHEMBL6997 fpr1_human Human No 7.0 IC50 = 100 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
543 14 5 6 3.3 CC1=CC(=CC=C1)NC(=O)NC(CCSC)C(=O)NC(CC(C)C)C(=O)NC(CC2=CC=CC=C2)C(=O)O
CHEMBL1770298 fpr1_human Human Yes 7.0 IC50 = 100 Funct
Displacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation countingDisplacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation counting
394 5 3 4 4.8 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=C(S2)C)NC(=O)C3=CC=CC=C3O
CHEMBL1916276 fpr1_human Human No 6.0 IC50 = 1000 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
453 6 2 5 5.2 CC1CCCCC1NC(=O)C2=C(N(N=C2)C3=CC=CC=C3)NS(=O)(=O)C4=CC=C(C=C4)C
CHEMBL1916287 fpr1_human Human No 6.0 IC50 = 1000 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
460 7 2 7 4.2 CC1=NN(C(=C1C(=O)NC(C)C(C)(C)C)NS(=O)(=O)C2=CN=CC=C2)C3=CC=C(C=C3)F
CHEMBL1916286 fpr1_human Human No 6.0 IC50 = 1000 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
447 7 2 5 5.4 CC1=NN(C(=C1C(=O)NC(C)C(C)(C)C)NS(=O)(=O)C2CCCCC2)C3=CC=CC=C3
CHEMBL1934423 fpr1_human Human No 6.0 IC50 = 1000 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
449 7 2 6 3.8 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3CCOC3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1934267 fpr1_human Human No 6.0 IC50 = 1000 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
421 7 2 5 4.5 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C(C)C)C)C(=O)NC(C)C(C)(C)C
CHEMBL1770484 fpr1_human Human No 6.0 IC50 = 1000 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
391 7 2 4 5.0 CCCC(C1=NC2=CC=CC=C2N1)NC(=O)C3=C(C4=C(O3)C=CC(=C4)OCC)C
CHEMBL1770476 fpr1_human Human No 6.0 IC50 = 1000 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
425 8 2 6 3.7 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CCSC)C3=NC4=C(N3)C=NC=C4
CHEMBL1916276 fpr1_human Human No 6.0 IC50 = 1000 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
453 6 2 5 5.2 CC1CCCCC1NC(=O)C2=C(N(N=C2)C3=CC=CC=C3)NS(=O)(=O)C4=CC=C(C=C4)C
CHEMBL1916287 fpr1_human Human No 6.0 IC50 = 1000 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
460 7 2 7 4.2 CC1=NN(C(=C1C(=O)NC(C)C(C)(C)C)NS(=O)(=O)C2=CN=CC=C2)C3=CC=C(C=C3)F
CHEMBL1916286 fpr1_human Human No 6.0 IC50 = 1000 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
447 7 2 5 5.4 CC1=NN(C(=C1C(=O)NC(C)C(C)(C)C)NS(=O)(=O)C2CCCCC2)C3=CC=CC=C3
CHEMBL1934423 fpr1_human Human No 6.0 IC50 = 1000 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
449 7 2 6 3.8 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3CCOC3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1934267 fpr1_human Human No 6.0 IC50 = 1000 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
421 7 2 5 4.5 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C(C)C)C)C(=O)NC(C)C(C)(C)C
CHEMBL268823 fpr1_human Human No 6.0 IC50 = 1000 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
509 15 5 6 2.7 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)NCC(C)C
CHEMBL7214 fpr1_human Human No 6.0 IC50 = 1000 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
481 14 5 6 1.7 CCNC(=O)NC(CCSC)C(=O)NC(CC(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)O
CHEMBL1770484 fpr1_human Human No 6.0 IC50 = 1000 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
391 7 2 4 5.0 CCCC(C1=NC2=CC=CC=C2N1)NC(=O)C3=C(C4=C(O3)C=CC(=C4)OCC)C
CHEMBL1770476 fpr1_human Human No 6.0 IC50 = 1000 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
425 8 2 6 3.7 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CCSC)C3=NC4=C(N3)C=NC=C4
CHEMBL832 fpr1_human Human Yes 5.0 IC50 = 10000 Funct
Antagonist activity at FPR1Antagonist activity at FPR1
404 6 0 4 2.3 C1=CC=C(C=C1)N2C(=O)C(C(=O)N2C3=CC=CC=C3)CCS(=O)C4=CC=CC=C4
CHEMBL1916264 fpr1_human Human No 5.0 IC50 = 10000 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
461 8 2 5 5.4 CCC(CC)NC(=O)C1=C(N(N=C1)C2=CC=CC=C2Cl)NS(=O)(=O)C3=CC=C(C=C3)C
CHEMBL1916268 fpr1_human Human No 5.0 IC50 = 10000 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
393 8 2 5 3.8 CCC(CC)NC(=O)C1=C(N(N=C1)C(C)C)NS(=O)(=O)C2=CC=C(C=C2)C
CHEMBL1916263 fpr1_human Human No 5.0 IC50 = 10000 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
427 8 2 5 4.8 CCC(CC)NC(=O)C1=CN(N=C1NS(=O)(=O)C2=CC=C(C=C2)C)C3=CC=CC=C3
CHEMBL1916086 fpr1_human Human No 5.0 IC50 = 10000 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
447 7 2 5 4.4 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=NN2C3=CC=CC=C3)C(=O)NCC4=CC=CC=C4
CHEMBL1916257 fpr1_human Human No 5.0 IC50 = 10000 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
441 6 2 6 3.3 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=NN2C3=CC=CC=C3)C(=O)NC4CCOCC4
CHEMBL1934419 fpr1_human Human No 5.0 IC50 = 10000 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
511 7 2 7 3.7 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3CCS(=O)(=O)CC3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1770469 fpr1_human Human Yes 5.0 IC50 = 10000 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
327 6 2 5 1.5 CSCCC(C1=NC2=CC=CC=C2N1)NC(=O)C3=NC=CN=C3
CHEMBL1770472 fpr1_human Human No 5.0 IC50 = 10000 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
339 6 2 3 3.7 CC1=CC=C(C=C1)C(=O)NC(CCSC)C2=NC3=CC=CC=C3N2
CHEMBL1770308 fpr1_human Human No 5.0 IC50 = 10000 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
388 5 2 3 4.9 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=CC=C2)N(C)C(=O)C3=CC=CC=C3O
CHEMBL1770482 fpr1_human Human No 5.0 IC50 = 10000 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
442 7 2 6 3.1 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CS(=O)(=O)C)C3=NC4=CC=CC=C4N3
CHEMBL1770470 fpr1_human Human No 5.0 IC50 = 10000 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
330 6 2 5 2.5 CC1=C(OC=N1)C(=O)NC(CCSC)C2=NC3=CC=CC=C3N2
CHEMBL832 fpr1_human Human Yes 5.0 IC50 = 10000 Funct
Antagonist activity at FPR1Antagonist activity at FPR1
404 6 0 4 2.3 C1=CC=C(C=C1)N2C(=O)C(C(=O)N2C3=CC=CC=C3)CCS(=O)C4=CC=CC=C4
CHEMBL1916264 fpr1_human Human No 5.0 IC50 = 10000 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
461 8 2 5 5.4 CCC(CC)NC(=O)C1=C(N(N=C1)C2=CC=CC=C2Cl)NS(=O)(=O)C3=CC=C(C=C3)C
CHEMBL1916268 fpr1_human Human No 5.0 IC50 = 10000 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
393 8 2 5 3.8 CCC(CC)NC(=O)C1=C(N(N=C1)C(C)C)NS(=O)(=O)C2=CC=C(C=C2)C
CHEMBL1916263 fpr1_human Human No 5.0 IC50 = 10000 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
427 8 2 5 4.8 CCC(CC)NC(=O)C1=CN(N=C1NS(=O)(=O)C2=CC=C(C=C2)C)C3=CC=CC=C3
CHEMBL1916086 fpr1_human Human No 5.0 IC50 = 10000 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
447 7 2 5 4.4 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=NN2C3=CC=CC=C3)C(=O)NCC4=CC=CC=C4
CHEMBL1916257 fpr1_human Human No 5.0 IC50 = 10000 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
441 6 2 6 3.3 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=NN2C3=CC=CC=C3)C(=O)NC4CCOCC4
CHEMBL1934419 fpr1_human Human No 5.0 IC50 = 10000 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
511 7 2 7 3.7 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3CCS(=O)(=O)CC3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1770469 fpr1_human Human Yes 5.0 IC50 = 10000 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
327 6 2 5 1.5 CSCCC(C1=NC2=CC=CC=C2N1)NC(=O)C3=NC=CN=C3
CHEMBL1770472 fpr1_human Human No 5.0 IC50 = 10000 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
339 6 2 3 3.7 CC1=CC=C(C=C1)C(=O)NC(CCSC)C2=NC3=CC=CC=C3N2
CHEMBL1770308 fpr1_human Human No 5.0 IC50 = 10000 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
388 5 2 3 4.9 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=CC=C2)N(C)C(=O)C3=CC=CC=C3O
CHEMBL1770482 fpr1_human Human No 5.0 IC50 = 10000 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
442 7 2 6 3.1 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CS(=O)(=O)C)C3=NC4=CC=CC=C4N3
CHEMBL1770470 fpr1_human Human No 5.0 IC50 = 10000 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
330 6 2 5 2.5 CC1=C(OC=N1)C(=O)NC(CCSC)C2=NC3=CC=CC=C3N2
CHEMBL1916289 fpr1_human Human No 7.9 IC50 = 12.6 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
527 7 2 9 6.1 CC1=NN(C(=C1C(=O)NC(C)C(C)(C)C)NS(=O)(=O)C2=CC=C(C=C2)C(F)(F)F)C3=CC=C(C=C3)F
CHEMBL1916289 fpr1_human Human No 7.9 IC50 = 12.6 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
527 7 2 9 6.1 CC1=NN(C(=C1C(=O)NC(C)C(C)(C)C)NS(=O)(=O)C2=CC=C(C=C2)C(F)(F)F)C3=CC=C(C=C3)F
CHEMBL1916281 fpr1_human Human No 6.9 IC50 = 125.9 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
455 7 2 5 5.5 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1916281 fpr1_human Human No 6.9 IC50 = 125.9 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
455 7 2 5 5.5 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1770153 fpr1_human Human Yes 5.9 IC50 = 1258.9 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
374 5 3 3 4.7 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=CC=C2)NC(=O)C3=CC=CC=C3O
CHEMBL1770153 fpr1_human Human Yes 5.9 IC50 = 1258.9 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
374 5 3 3 4.7 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=CC=C2)NC(=O)C3=CC=CC=C3O
CHEMBL3311300 fpr1_human Human No 6.9 IC50 = 140 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
894 24 6 9 8.8 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CCCCC2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=C(C=C3)C(=O)C4=CC=CC=C4)NC(=O)OC(C)(C)C
CHEMBL3311300 fpr1_human Human No 6.9 IC50 = 140 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
894 24 6 9 8.8 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CCCCC2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=C(C=C3)C(=O)C4=CC=CC=C4)NC(=O)OC(C)(C)C
CHEMBL2372498 fpr1_human Human No 5.8 IC50 = 1480 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1279 18 9 15 6.1 CC1C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)N1)CC(C)C)C)CC(C)C)CC(C)C)C)C)C(C)O)C(C(C)CC=CCO)O)C)C(C)C)C)CC(C)C)CC(C)C)C)(C(C)C)O
CHEMBL2021596 fpr1_human Human No 6.8 IC50 = 150 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1201 15 4 11 8.4 CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C)C(C)CC=CC)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
CHEMBL2369724 fpr1_human Human No 5.8 IC50 = 1570 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1217 16 5 12 7.9 CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)CC)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
CHEMBL1770297 fpr1_human Human No 6.8 IC50 = 158.5 Funct
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay
424 8 2 5 4.8 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CCSC)C3=NC4=CC=CC=C4N3
CHEMBL1916277 fpr1_human Human No 6.8 IC50 = 158.5 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
467 6 2 5 5.6 CC1CCCCC1NC(=O)C2=C(N(N=C2C)C3=CC=CC=C3)NS(=O)(=O)C4=CC=C(C=C4)C
CHEMBL1916280 fpr1_human Human No 6.8 IC50 = 158.5 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
427 7 2 5 4.7 CCC(C)NC(=O)C1=C(N(N=C1C)C2=CC=CC=C2)NS(=O)(=O)C3=CC=C(C=C3)C
CHEMBL1934426 fpr1_human Human No 6.8 IC50 = 158.5 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
489 8 2 6 4.7 CC1=NN(C(=C1C(=O)NC(C)C(C)(C)C)NS(=O)(=O)C2=CC=C(C=C2)C3CC3)C4CCOCC4
CHEMBL1770297 fpr1_human Human No 6.8 IC50 = 158.5 Funct
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay
424 8 2 5 4.8 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CCSC)C3=NC4=CC=CC=C4N3
CHEMBL1916277 fpr1_human Human No 6.8 IC50 = 158.5 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
467 6 2 5 5.6 CC1CCCCC1NC(=O)C2=C(N(N=C2C)C3=CC=CC=C3)NS(=O)(=O)C4=CC=C(C=C4)C
CHEMBL1916280 fpr1_human Human No 6.8 IC50 = 158.5 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
427 7 2 5 4.7 CCC(C)NC(=O)C1=C(N(N=C1C)C2=CC=CC=C2)NS(=O)(=O)C3=CC=C(C=C3)C
CHEMBL1934426 fpr1_human Human No 6.8 IC50 = 158.5 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
489 8 2 6 4.7 CC1=NN(C(=C1C(=O)NC(C)C(C)(C)C)NS(=O)(=O)C2=CC=C(C=C2)C3CC3)C4CCOCC4
CHEMBL1770298 fpr1_human Human Yes 5.8 IC50 = 1584.9 Funct
Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay
394 5 3 4 4.8 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=C(S2)C)NC(=O)C3=CC=CC=C3O
CHEMBL1916262 fpr1_human Human No 5.8 IC50 = 1584.9 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
427 8 2 5 4.9 CCC(CC)NC(=O)C1=C(N(C=N1)C2=CC=CC=C2)NS(=O)(=O)C3=CC=C(C=C3)C
CHEMBL1916085 fpr1_human Human No 5.8 IC50 = 1584.9 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
453 6 1 5 4.9 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=NN2C3=CC=CC=C3)C(=O)N(C)C4CCCCC4
CHEMBL1934270 fpr1_human Human No 5.8 IC50 = 1584.9 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
435 7 2 5 4.7 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C(C)(C)C)C)C(=O)NC(C)C(C)(C)C
CHEMBL1770301 fpr1_human Human No 5.8 IC50 = 1584.9 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
378 5 3 4 2.9 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CN(C=N2)C)NC(=O)C3=CC=CC=C3O
CHEMBL1770298 fpr1_human Human Yes 5.8 IC50 = 1584.9 Funct
Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay
394 5 3 4 4.8 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=C(S2)C)NC(=O)C3=CC=CC=C3O
CHEMBL1916262 fpr1_human Human No 5.8 IC50 = 1584.9 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
427 8 2 5 4.9 CCC(CC)NC(=O)C1=C(N(C=N1)C2=CC=CC=C2)NS(=O)(=O)C3=CC=C(C=C3)C
CHEMBL1916085 fpr1_human Human No 5.8 IC50 = 1584.9 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
453 6 1 5 4.9 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=NN2C3=CC=CC=C3)C(=O)N(C)C4CCCCC4
CHEMBL1934270 fpr1_human Human No 5.8 IC50 = 1584.9 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
435 7 2 5 4.7 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C(C)(C)C)C)C(=O)NC(C)C(C)(C)C
CHEMBL1770301 fpr1_human Human No 5.8 IC50 = 1584.9 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
378 5 3 4 2.9 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CN(C=N2)C)NC(=O)C3=CC=CC=C3O
CHEMBL1916265 fpr1_human Human No 4.8 IC50 = 15848.9 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
452 8 2 6 4.5 CCC(CC)NC(=O)C1=C(N(N=C1)C2=CC=C(C=C2)C#N)NS(=O)(=O)C3=CC=C(C=C3)C
CHEMBL1916265 fpr1_human Human No 4.8 IC50 = 15848.9 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
452 8 2 6 4.5 CCC(CC)NC(=O)C1=C(N(N=C1)C2=CC=C(C=C2)C#N)NS(=O)(=O)C3=CC=C(C=C3)C
CHEMBL6997 fpr1_human Human No 5.8 IC50 = 1600 Funct
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
543 14 5 6 3.3 CC1=CC(=CC=C1)NC(=O)NC(CCSC)C(=O)NC(CC(C)C)C(=O)NC(CC2=CC=CC=C2)C(=O)O
CHEMBL2372478 fpr1_human Human No 5.8 IC50 = 1800 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1175 15 7 12 7.2 CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)CC(C)C)C)C)C)CC(C)C)C(C)C)CC(C)C)C)C
CHEMBL1934413 fpr1_human Human No 6.7 IC50 = 199.5 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
433 7 2 5 4.7 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3CCC3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1934413 fpr1_human Human No 6.7 IC50 = 199.5 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
433 7 2 5 4.7 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3CCC3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1916279 fpr1_human Human No 5.7 IC50 = 1995.3 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
441 7 2 5 5.1 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C)C(=O)NCC(C)(C)C
CHEMBL1916082 fpr1_human Human No 5.7 IC50 = 1995.3 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
427 8 2 5 4.8 CCC(CC)NC(=O)C1=C(N(N=C1)C2=CC=CC=C2)NS(=O)(=O)C3=CC=C(C=C3)C
CHEMBL1770471 fpr1_human Human No 5.7 IC50 = 1995.3 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
366 6 2 4 4.0 CSCCC(C1=NC2=CC=CC=C2N1)NC(=O)C3=C(C=CS3)Cl
CHEMBL1916279 fpr1_human Human No 5.7 IC50 = 1995.3 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
441 7 2 5 5.1 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C)C(=O)NCC(C)(C)C
CHEMBL1916082 fpr1_human Human No 5.7 IC50 = 1995.3 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
427 8 2 5 4.8 CCC(CC)NC(=O)C1=C(N(N=C1)C2=CC=CC=C2)NS(=O)(=O)C3=CC=C(C=C3)C
CHEMBL1770471 fpr1_human Human No 5.7 IC50 = 1995.3 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
366 6 2 4 4.0 CSCCC(C1=NC2=CC=CC=C2N1)NC(=O)C3=C(C=CS3)Cl
CHEMBL1916266 fpr1_human Human No 4.7 IC50 = 19952.6 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
428 8 2 6 4.1 CCC(CC)NC(=O)C1=C(N(N=C1)C2=CC=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)C
CHEMBL1916266 fpr1_human Human No 4.7 IC50 = 19952.6 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
428 8 2 6 4.1 CCC(CC)NC(=O)C1=C(N(N=C1)C2=CC=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)C
CHEMBL267388 fpr1_human Human No 8.7 IC50 = 2 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
563 14 5 6 3.5 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)NC2=CC=C(C=C2)Cl
CHEMBL266802 fpr1_human Human No 8.7 IC50 = 2 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
543 14 5 6 3.3 CC1=CC=C(C=C1)NC(=O)NC(CCSC)C(=O)NC(CC(C)C)C(=O)NC(CC2=CC=CC=C2)C(=O)O
CHEMBL7753 fpr1_human Human No 8.7 IC50 = 2 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
559 15 5 7 2.9 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)NC2=CC=C(C=C2)OC
CHEMBL7486 fpr1_human Human No 7.7 IC50 = 20 Funct
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
819 21 7 7 7.7 CC1=CC(=CC=C1)NC(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC(C)C)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC(C)C)C(=O)NC(CC4=CC=CC=C4)C(=O)O
CHEMBL267179 fpr1_human Human Yes 7.7 IC50 = 20 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
None None None CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC=O
CHEMBL415296 fpr1_human Human No 7.7 IC50 = 20 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
863 21 7 7 8.4 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)NC45CC6CC(C4)CC(C6)C5
CHEMBL7486 fpr1_human Human No 6.7 IC50 = 200 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
819 21 7 7 7.7 CC1=CC(=CC=C1)NC(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC(C)C)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC(C)C)C(=O)NC(CC4=CC=CC=C4)C(=O)O
CHEMBL7122 fpr1_human Human No 6.7 IC50 = 200 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
771 21 7 7 6.6 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)NC(C)C
CHEMBL3311030 fpr1_human Human Yes 5.7 IC50 = 2000 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
786 22 6 8 6.6 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)OC(C)(C)C
CHEMBL3311030 fpr1_human Human Yes 5.7 IC50 = 2000 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
786 22 6 8 6.6 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)OC(C)(C)C
CHEMBL7181 fpr1_human Human No 5.7 IC50 = 2000 Funct
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
467 13 5 6 1.3 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)NC
CHEMBL415299 fpr1_human Human No 5.7 IC50 = 2000 Funct
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
509 14 5 6 2.3 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)NC(C)(C)C
CHEMBL6779 fpr1_human Human No 5.7 IC50 = 2000 Funct
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
587 14 5 6 4.0 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)NC23CC4CC(C2)CC(C4)C3
CHEMBL266448 fpr1_human Human No 5.7 IC50 = 2000 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
495 15 5 6 2.2 CCCNC(=O)NC(CCSC)C(=O)NC(CC(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)O
CHEMBL7306 fpr1_human Human No 5.7 IC50 = 2000 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
453 13 5 6 0.9 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)N
CHEMBL7034 fpr1_human Human No 5.7 IC50 = 2000 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
495 14 5 6 2.1 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)NC(C)C
CHEMBL2372474 fpr1_human Human No 5.7 IC50 = 2200 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1175 14 6 12 6.8 CC=CCC(C)C(C1C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C)O
CHEMBL2372461 fpr1_human Human No 5.6 IC50 = 2300 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1233 16 6 13 7.3 CCC(C)C1C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)N1)CC(C)C)C)C)C(C)O)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C
CHEMBL1916288 fpr1_human Human No 7.6 IC50 = 25.1 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
484 7 2 7 5.0 CC1=NN(C(=C1C(=O)NC(C)C(C)(C)C)NS(=O)(=O)C2=CC=C(C=C2)C#N)C3=CC=C(C=C3)F
CHEMBL1916284 fpr1_human Human No 7.6 IC50 = 25.1 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
509 7 2 8 6.0 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C(F)(F)F)C(=O)NC(C)C(C)(C)C
CHEMBL1916288 fpr1_human Human No 7.6 IC50 = 25.1 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
484 7 2 7 5.0 CC1=NN(C(=C1C(=O)NC(C)C(C)(C)C)NS(=O)(=O)C2=CC=C(C=C2)C#N)C3=CC=C(C=C3)F
CHEMBL1916288 fpr1_human Human No 7.6 IC50 = 25.1 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
484 7 2 7 5.0 CC1=NN(C(=C1C(=O)NC(C)C(C)(C)C)NS(=O)(=O)C2=CC=C(C=C2)C#N)C3=CC=C(C=C3)F
CHEMBL1916284 fpr1_human Human No 7.6 IC50 = 25.1 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
509 7 2 8 6.0 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C(F)(F)F)C(=O)NC(C)C(C)(C)C
CHEMBL1916288 fpr1_human Human No 7.6 IC50 = 25.1 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
484 7 2 7 5.0 CC1=NN(C(=C1C(=O)NC(C)C(C)(C)C)NS(=O)(=O)C2=CC=C(C=C2)C#N)C3=CC=C(C=C3)F
CHEMBL2372504 fpr1_human Human No 5.6 IC50 = 2500 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1249 16 8 14 7.0 CC=CCC(C)C(C1C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)CC(C)C)C)(C(C)C)O)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C(C)O)O
CHEMBL1770296 fpr1_human Human Yes 5.6 IC50 = 2511.9 Funct
Antagonist activity at FPR1Antagonist activity at FPR1
510 15 4 7 2.9 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)OC(C)(C)C
CHEMBL1934416 fpr1_human Human No 5.6 IC50 = 2511.9 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
451 9 2 6 4.0 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C(C)COC)C)C(=O)NC(C)C(C)(C)C
CHEMBL1770304 fpr1_human Human No 5.6 IC50 = 2511.9 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
387 5 3 3 4.9 C1CCC(CC1)NC(=O)C(C2=CC=C(C=C2)Cl)NC(=O)C3=CC=CC=C3O
CHEMBL1770307 fpr1_human Human No 5.6 IC50 = 2511.9 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
461 5 3 4 4.9 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=C(C=C2)Cl)NC(=O)C3=NC4=CC=CC=C4NC3=O
CHEMBL1545798 fpr1_human Human Yes 5.6 IC50 = 2511.9 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
331 6 2 3 3.8 CSCCC(C1=NC2=CC=CC=C2N1)NC(=O)C3CCCCC3
CHEMBL1770474 fpr1_human Human Yes 5.6 IC50 = 2511.9 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
416 8 1 3 4.9 CSCCC(C1=NC2=CC=CC=C2N1CC3=CC=CC=C3)NC(=O)C4=CC=CC=C4
CHEMBL1770296 fpr1_human Human Yes 5.6 IC50 = 2511.9 Funct
Antagonist activity at FPR1Antagonist activity at FPR1
510 15 4 7 2.9 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)OC(C)(C)C
CHEMBL1934416 fpr1_human Human No 5.6 IC50 = 2511.9 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
451 9 2 6 4.0 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C(C)COC)C)C(=O)NC(C)C(C)(C)C
CHEMBL1770304 fpr1_human Human No 5.6 IC50 = 2511.9 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
387 5 3 3 4.9 C1CCC(CC1)NC(=O)C(C2=CC=C(C=C2)Cl)NC(=O)C3=CC=CC=C3O
CHEMBL1770307 fpr1_human Human No 5.6 IC50 = 2511.9 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
461 5 3 4 4.9 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=C(C=C2)Cl)NC(=O)C3=NC4=CC=CC=C4NC3=O
CHEMBL1545798 fpr1_human Human Yes 5.6 IC50 = 2511.9 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
331 6 2 3 3.8 CSCCC(C1=NC2=CC=CC=C2N1)NC(=O)C3CCCCC3
CHEMBL1770474 fpr1_human Human Yes 5.6 IC50 = 2511.9 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
416 8 1 3 4.9 CSCCC(C1=NC2=CC=CC=C2N1CC3=CC=CC=C3)NC(=O)C4=CC=CC=C4
CHEMBL1934266 fpr1_human Human No 4.6 IC50 = 25118.9 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
407 8 2 5 4.2 CCC(CC)NC(=O)C1=C(N(N=C1C)C(C)C)NS(=O)(=O)C2=CC=C(C=C2)C
CHEMBL1770298 fpr1_mouse Mouse Yes 4.6 IC50 = 25118.9 Funct
Antagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assay
394 5 3 4 4.8 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=C(S2)C)NC(=O)C3=CC=CC=C3O
CHEMBL1934266 fpr1_human Human No 4.6 IC50 = 25118.9 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
407 8 2 5 4.2 CCC(CC)NC(=O)C1=C(N(N=C1C)C(C)C)NS(=O)(=O)C2=CC=C(C=C2)C
CHEMBL1770298 fpr1_mouse Mouse Yes 4.6 IC50 = 25118.9 Funct
Antagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assay
394 5 3 4 4.8 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=C(S2)C)NC(=O)C3=CC=CC=C3O
CHEMBL2372477 fpr1_human Human No 5.6 IC50 = 2520 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1175 14 5 12 6.6 CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
CHEMBL1934424 fpr1_human Human No 8.4 IC50 = 4.0 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
491 8 2 6 4.9 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3CCC(CC3)OC)C)C(=O)NC(C)C(C)(C)C
CHEMBL1934424 fpr1_human Human No 8.4 IC50 = 4.0 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
491 8 2 6 4.9 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3CCC(CC3)OC)C)C(=O)NC(C)C(C)(C)C
CHEMBL7520 fpr1_human Human No 7.5 IC50 = 30 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
529 14 5 6 2.9 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)NC2=CC=CC=C2
CHEMBL415296 fpr1_human Human No 6.5 IC50 = 300 Funct
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
863 21 7 7 8.4 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)NC45CC6CC(C4)CC(C6)C5
CHEMBL265408 fpr1_human Human No 6.5 IC50 = 300 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
509 16 5 6 2.6 CCCCNC(=O)NC(CCSC)C(=O)NC(CC(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)O
CHEMBL266089 fpr1_human Human No 6.5 IC50 = 300 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
493 14 5 6 2.2 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)NC(=C)C
CHEMBL7363 fpr1_human Human No 6.5 IC50 = 300 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
785 23 7 7 7.0 CCCCNC(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC(C)C)C(=O)NC(CC3=CC=CC=C3)C(=O)O
CHEMBL2372488 fpr1_human Human No 6.5 IC50 = 300 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1249 17 9 14 7.1 CC=CCC(C)C(C1C(=O)NC(C(=O)NCC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)CC(C)C)C)(C(C)C)O)C)CC(C)C)C)CC(C)C)CC(C)C)C)C(C)O)O
CHEMBL266448 fpr1_human Human No 5.5 IC50 = 3000 Funct
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
495 15 5 6 2.2 CCCNC(=O)NC(CCSC)C(=O)NC(CC(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)O
CHEMBL7214 fpr1_human Human No 5.5 IC50 = 3000 Funct
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
481 14 5 6 1.7 CCNC(=O)NC(CCSC)C(=O)NC(CC(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)O
CHEMBL7181 fpr1_human Human No 5.5 IC50 = 3000 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
467 13 5 6 1.3 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)NC
CHEMBL415299 fpr1_human Human No 5.5 IC50 = 3000 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
509 14 5 6 2.3 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)NC(C)(C)C
CHEMBL2372495 fpr1_human Human No 5.5 IC50 = 3000 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1189 15 6 12 7.3 CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
CHEMBL1934415 fpr1_human Human No 7.5 IC50 = 31.6 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
461 7 2 5 5.6 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3CCCCC3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1770297 fpr1_human Human No 7.5 IC50 = 31.6 Funct
Displacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation countingDisplacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation counting
424 8 2 5 4.8 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CCSC)C3=NC4=CC=CC=C4N3
CHEMBL1934415 fpr1_human Human No 7.5 IC50 = 31.6 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
461 7 2 5 5.6 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3CCCCC3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1770297 fpr1_human Human No 7.5 IC50 = 31.6 Funct
Displacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation countingDisplacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation counting
424 8 2 5 4.8 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CCSC)C3=NC4=CC=CC=C4N3
CHEMBL1916255 fpr1_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
441 9 2 5 5.2 CCCC(CC)NC(=O)C1=C(N(N=C1)C2=CC=CC=C2)NS(=O)(=O)C3=CC=C(C=C3)C
CHEMBL1934417 fpr1_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
465 10 2 6 4.4 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C(C)CCOC)C)C(=O)NC(C)C(C)(C)C
CHEMBL1934422 fpr1_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
463 7 2 6 4.2 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3CCOCC3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1770475 fpr1_human Human Yes 6.5 IC50 = 316.2 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
441 8 1 4 4.6 CSCCC(C1=NC2=CC=CC=C2N1CC3=CC=C(C=C3)C#N)NC(=O)C4=CC=CC=C4
CHEMBL1770298 fpr1_human Human Yes 6.5 IC50 = 316.2 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
394 5 3 4 4.8 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=C(S2)C)NC(=O)C3=CC=CC=C3O
CHEMBL1916255 fpr1_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
441 9 2 5 5.2 CCCC(CC)NC(=O)C1=C(N(N=C1)C2=CC=CC=C2)NS(=O)(=O)C3=CC=C(C=C3)C
CHEMBL1934417 fpr1_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
465 10 2 6 4.4 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C(C)CCOC)C)C(=O)NC(C)C(C)(C)C
CHEMBL1934422 fpr1_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
463 7 2 6 4.2 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3CCOCC3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1770475 fpr1_human Human Yes 6.5 IC50 = 316.2 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
441 8 1 4 4.6 CSCCC(C1=NC2=CC=CC=C2N1CC3=CC=C(C=C3)C#N)NC(=O)C4=CC=CC=C4
CHEMBL1770298 fpr1_human Human Yes 6.5 IC50 = 316.2 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
394 5 3 4 4.8 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=C(S2)C)NC(=O)C3=CC=CC=C3O
CHEMBL1770297 fpr1_human Human No 5.5 IC50 = 3162.3 Funct
Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay
424 8 2 5 4.8 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CCSC)C3=NC4=CC=CC=C4N3
CHEMBL1916275 fpr1_human Human No 5.5 IC50 = 3162.3 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
467 6 1 5 5.3 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C)C(=O)N(C)C4CCCCC4
CHEMBL1934269 fpr1_human Human No 5.5 IC50 = 3162.3 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
461 7 2 8 4.9 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2CC(F)(F)F)C)C(=O)NC(C)C(C)(C)C
CHEMBL1934421 fpr1_human Human No 5.5 IC50 = 3162.3 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
544 8 2 9 5.4 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3CCN(CC3)CC(F)(F)F)C)C(=O)NC(C)C(C)(C)C
CHEMBL1770477 fpr1_human Human No 5.5 IC50 = 3162.3 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
425 8 2 6 4.0 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CCSC)C3=NC4=C(N3)C=CC=N4
CHEMBL1770297 fpr1_human Human No 5.5 IC50 = 3162.3 Funct
Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay
424 8 2 5 4.8 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CCSC)C3=NC4=CC=CC=C4N3
CHEMBL1916275 fpr1_human Human No 5.5 IC50 = 3162.3 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
467 6 1 5 5.3 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C)C(=O)N(C)C4CCCCC4
CHEMBL1934269 fpr1_human Human No 5.5 IC50 = 3162.3 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
461 7 2 8 4.9 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2CC(F)(F)F)C)C(=O)NC(C)C(C)(C)C
CHEMBL1934421 fpr1_human Human No 5.5 IC50 = 3162.3 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
544 8 2 9 5.4 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3CCN(CC3)CC(F)(F)F)C)C(=O)NC(C)C(C)(C)C
CHEMBL1770477 fpr1_human Human No 5.5 IC50 = 3162.3 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
425 8 2 6 4.0 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CCSC)C3=NC4=C(N3)C=CC=N4
CHEMBL2372506 fpr1_human Human No 5.5 IC50 = 3250 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1177 14 7 13 5.8 CC=CCC(C)C(C1C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)N1C)C(C)C)C)C)CC(C)C)C)C)C)CC(C)C)C)CC(C)C)CC(C)C)C)C)C(C)O)O
CHEMBL2372456 fpr1_human Human No 5.5 IC50 = 3400 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1217 17 5 12 7.8 CCCC1C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)N1)CC(C)C)C)C)CCC)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C
CHEMBL1934418 fpr1_human Human No 7.4 IC50 = 39.8 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
479 7 2 6 4.9 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3CCSCC3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1934418 fpr1_human Human No 7.4 IC50 = 39.8 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
479 7 2 6 4.9 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3CCSCC3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1770298 fpr1_human Human Yes 6.4 IC50 = 398.1 Funct
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay
394 5 3 4 4.8 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=C(S2)C)NC(=O)C3=CC=CC=C3O
CHEMBL1770298 fpr1_human Human Yes 6.4 IC50 = 398.1 Funct
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay
394 5 3 4 4.8 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=C(S2)C)NC(=O)C3=CC=CC=C3O
CHEMBL1770298 fpr1_human Human Yes 6.4 IC50 = 398.1 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
394 5 3 4 4.8 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=C(S2)C)NC(=O)C3=CC=CC=C3O
CHEMBL1934271 fpr1_human Human No 6.4 IC50 = 398.1 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
449 9 2 5 5.6 CCC(CC)N1C(=C(C(=N1)C)C(=O)NC(C)C(C)(C)C)NS(=O)(=O)C2=CC=C(C=C2)C
CHEMBL1770298 fpr1_human Human Yes 6.4 IC50 = 398.1 Funct
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay
394 5 3 4 4.8 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=C(S2)C)NC(=O)C3=CC=CC=C3O
CHEMBL1770298 fpr1_human Human Yes 6.4 IC50 = 398.1 Funct
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay
394 5 3 4 4.8 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=C(S2)C)NC(=O)C3=CC=CC=C3O
CHEMBL1770298 fpr1_human Human Yes 6.4 IC50 = 398.1 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
394 5 3 4 4.8 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=C(S2)C)NC(=O)C3=CC=CC=C3O
CHEMBL1934271 fpr1_human Human No 6.4 IC50 = 398.1 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
449 9 2 5 5.6 CCC(CC)N1C(=C(C(=N1)C)C(=O)NC(C)C(C)(C)C)NS(=O)(=O)C2=CC=C(C=C2)C
CHEMBL1916084 fpr1_human Human No 5.4 IC50 = 3981.1 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
439 6 2 5 4.8 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=NN2C3=CC=CC=C3)C(=O)NC4CCCCC4
CHEMBL1916261 fpr1_human Human No 5.4 IC50 = 3981.1 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
428 8 2 6 4.6 CCC(CC)NC(=O)C1=C(N(N=N1)C2=CC=CC=C2)NS(=O)(=O)C3=CC=C(C=C3)C
CHEMBL1770309 fpr1_human Human Yes 5.4 IC50 = 3981.1 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
379 6 2 4 4.4 CC1=C(OC2=CC=CC=C12)C(=O)NC(CCSC)C3=NC4=CC=CC=C4N3
CHEMBL1770310 fpr1_human Human Yes 5.4 IC50 = 3981.1 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
329 6 2 4 3.1 CC1=C(OC=C1)C(=O)NC(CCSC)C2=NC3=CC=CC=C3N2
CHEMBL1770468 fpr1_human Human No 5.4 IC50 = 3981.1 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
341 6 3 4 3.5 CSCCC(C1=NC2=CC=CC=C2N1)NC(=O)C3=CC=CC=C3O
CHEMBL1916084 fpr1_human Human No 5.4 IC50 = 3981.1 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
439 6 2 5 4.8 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=NN2C3=CC=CC=C3)C(=O)NC4CCCCC4
CHEMBL1916261 fpr1_human Human No 5.4 IC50 = 3981.1 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
428 8 2 6 4.6 CCC(CC)NC(=O)C1=C(N(N=N1)C2=CC=CC=C2)NS(=O)(=O)C3=CC=C(C=C3)C
CHEMBL1770309 fpr1_human Human Yes 5.4 IC50 = 3981.1 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
379 6 2 4 4.4 CC1=C(OC2=CC=CC=C12)C(=O)NC(CCSC)C3=NC4=CC=CC=C4N3
CHEMBL1770310 fpr1_human Human Yes 5.4 IC50 = 3981.1 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
329 6 2 4 3.1 CC1=C(OC=C1)C(=O)NC(CCSC)C2=NC3=CC=CC=C3N2
CHEMBL1770468 fpr1_human Human No 5.4 IC50 = 3981.1 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
341 6 3 4 3.5 CSCCC(C1=NC2=CC=CC=C2N1)NC(=O)C3=CC=CC=C3O
CHEMBL268823 fpr1_human Human No 5.4 IC50 = 4000 Funct
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
509 15 5 6 2.7 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)NCC(C)C
CHEMBL3311137 fpr1_human Human No 6.4 IC50 = 420 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
890 24 6 9 8.0 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=C(C=C3)C(=O)C4=CC=CC=C4)NC(=O)OC(C)(C)C
CHEMBL3311137 fpr1_human Human No 6.4 IC50 = 420 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
890 24 6 9 8.0 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=C(C=C3)C(=O)C4=CC=CC=C4)NC(=O)OC(C)(C)C
CHEMBL162488 fpr1_human Human No 7.3 IC50 = 50 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
805 21 7 7 7.3 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)NC4=CC=CC=C4
CHEMBL162488 fpr1_human Human No 6.3 IC50 = 500 Funct
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
805 21 7 7 7.3 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)NC4=CC=CC=C4
CHEMBL7122 fpr1_human Human No 6.3 IC50 = 500 Funct
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
771 21 7 7 6.6 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)NC(C)C
CHEMBL7034 fpr1_human Human No 5.3 IC50 = 5000 Funct
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
495 14 5 6 2.1 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)NC(C)C
CHEMBL1770297 fpr1_human Human No 6.3 IC50 = 501.2 Funct
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay
424 8 2 5 4.8 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CCSC)C3=NC4=CC=CC=C4N3
CHEMBL1770297 fpr1_human Human No 6.3 IC50 = 501.2 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
424 8 2 5 4.8 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CCSC)C3=NC4=CC=CC=C4N3
CHEMBL1916283 fpr1_human Human No 6.3 IC50 = 501.2 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
455 7 2 5 5.5 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1916272 fpr1_human Human No 6.3 IC50 = 501.2 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
441 8 2 5 5.2 CCC(CC)NC(=O)C1=C(N(N=C1C)C2=CC=CC=C2)NS(=O)(=O)C3=CC=C(C=C3)C
CHEMBL1770297 fpr1_human Human No 6.3 IC50 = 501.2 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
424 8 2 5 4.8 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CCSC)C3=NC4=CC=CC=C4N3
CHEMBL1770297 fpr1_human Human No 6.3 IC50 = 501.2 Funct
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay
424 8 2 5 4.8 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CCSC)C3=NC4=CC=CC=C4N3
CHEMBL1770297 fpr1_human Human No 6.3 IC50 = 501.2 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
424 8 2 5 4.8 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CCSC)C3=NC4=CC=CC=C4N3
CHEMBL1916283 fpr1_human Human No 6.3 IC50 = 501.2 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
455 7 2 5 5.5 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1916272 fpr1_human Human No 6.3 IC50 = 501.2 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
441 8 2 5 5.2 CCC(CC)NC(=O)C1=C(N(N=C1C)C2=CC=CC=C2)NS(=O)(=O)C3=CC=C(C=C3)C
CHEMBL1770297 fpr1_human Human No 6.3 IC50 = 501.2 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
424 8 2 5 4.8 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CCSC)C3=NC4=CC=CC=C4N3
CHEMBL1770295 fpr1_human Human Yes 5.3 IC50 = 5011.9 Funct
Antagonist activity at FPR1Antagonist activity at FPR1
376 3 1 6 2.8 CC(C)C(C(=O)O)N1C(=O)C(=C2C3=CC=CC=C3N(C2=O)C)SC1=S
CHEMBL1916270 fpr1_human Human No 5.3 IC50 = 5011.9 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
480 9 2 7 4.5 CCC(CC)NC(=O)C1=C(N(N=C1)C2=CC=CC=C2)NS(=O)(=O)C3=CC=C(C=C3)C4=CN=CO4
CHEMBL1916260 fpr1_human Human No 5.3 IC50 = 5011.9 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
405 8 2 5 4.1 CCC(CC)NC(=O)C1=C(N(N=C1)C2=CC=CC=C2)NS(=O)(=O)C3CCCC3
CHEMBL1916259 fpr1_human Human No 5.3 IC50 = 5011.9 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
413 8 2 5 4.4 CCC(CC)NC(=O)C1=C(N(N=C1)C2=CC=CC=C2)NS(=O)(=O)C3=CC=CC=C3
CHEMBL1916267 fpr1_human Human No 5.3 IC50 = 5011.9 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
441 9 2 5 4.7 CCC(CC)NC(=O)C1=C(N(N=C1)CC2=CC=CC=C2)NS(=O)(=O)C3=CC=C(C=C3)C
CHEMBL1916278 fpr1_human Human No 5.3 IC50 = 5011.9 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
455 6 2 6 3.7 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C)C(=O)NC4CCOCC4
CHEMBL1770303 fpr1_human Human No 5.3 IC50 = 5011.9 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
381 5 3 3 4.6 C1=CC=C(C=C1)NC(=O)C(C2=CC=C(C=C2)Cl)NC(=O)C3=CC=CC=C3O
CHEMBL1770478 fpr1_human Human No 5.3 IC50 = 5011.9 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
426 8 2 7 3.4 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CCSC)C3=NC4=NC=NC=C4N3
CHEMBL1770466 fpr1_human Human Yes 5.3 IC50 = 5011.9 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
325 6 2 3 3.3 CSCCC(C1=NC2=CC=CC=C2N1)NC(=O)C3=CC=CC=C3
CHEMBL1770295 fpr1_human Human Yes 5.3 IC50 = 5011.9 Funct
Antagonist activity at FPR1Antagonist activity at FPR1
376 3 1 6 2.8 CC(C)C(C(=O)O)N1C(=O)C(=C2C3=CC=CC=C3N(C2=O)C)SC1=S
CHEMBL1916270 fpr1_human Human No 5.3 IC50 = 5011.9 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
480 9 2 7 4.5 CCC(CC)NC(=O)C1=C(N(N=C1)C2=CC=CC=C2)NS(=O)(=O)C3=CC=C(C=C3)C4=CN=CO4
CHEMBL1916260 fpr1_human Human No 5.3 IC50 = 5011.9 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
405 8 2 5 4.1 CCC(CC)NC(=O)C1=C(N(N=C1)C2=CC=CC=C2)NS(=O)(=O)C3CCCC3
CHEMBL1916259 fpr1_human Human No 5.3 IC50 = 5011.9 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
413 8 2 5 4.4 CCC(CC)NC(=O)C1=C(N(N=C1)C2=CC=CC=C2)NS(=O)(=O)C3=CC=CC=C3
CHEMBL1916267 fpr1_human Human No 5.3 IC50 = 5011.9 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
441 9 2 5 4.7 CCC(CC)NC(=O)C1=C(N(N=C1)CC2=CC=CC=C2)NS(=O)(=O)C3=CC=C(C=C3)C
CHEMBL1916278 fpr1_human Human No 5.3 IC50 = 5011.9 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
455 6 2 6 3.7 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C)C(=O)NC4CCOCC4
CHEMBL1770303 fpr1_human Human No 5.3 IC50 = 5011.9 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
381 5 3 3 4.6 C1=CC=C(C=C1)NC(=O)C(C2=CC=C(C=C2)Cl)NC(=O)C3=CC=CC=C3O
CHEMBL1770478 fpr1_human Human No 5.3 IC50 = 5011.9 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
426 8 2 7 3.4 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CCSC)C3=NC4=NC=NC=C4N3
CHEMBL1770466 fpr1_human Human Yes 5.3 IC50 = 5011.9 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
325 6 2 3 3.3 CSCCC(C1=NC2=CC=CC=C2N1)NC(=O)C3=CC=CC=C3
CHEMBL2370883 fpr1_human Human No 5.3 IC50 = 5500 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1205 15 7 13 6.8 CC=CCC(C)C(C1C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C(C)O)O
CHEMBL2372486 fpr1_human Human No 6.3 IC50 = 560 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1249 17 9 14 7.1 CC=CCC(C)C(C1C(=O)NC(C(=O)N(CC(=O)NC(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)CC(C)C)C)(C(C)C)O)C)CC(C)C)C)CC(C)C)CC(C)C)C)C(C)O)O
CHEMBL2372507 fpr1_human Human No 6.2 IC50 = 570 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1263 17 8 14 7.3 CC=CCC(C)C(C1C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)CC(C)C)C)(C(C)C)O)C)CC(C)C)C)CC(C)C)CC(C)C)C)C)C(C)O)O
CHEMBL2372505 fpr1_human Human No 6.2 IC50 = 590 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1219 16 7 13 7.1 CC=CCC(C)C(C1C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)CC(C)C)C)C)C)CC(C)C)C)CC(C)C)CC(C)C)C)C)C(C)O)O
CHEMBL7363 fpr1_human Human No 6.2 IC50 = 600 Funct
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
785 23 7 7 7.0 CCCCNC(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC(C)C)C(=O)NC(CC3=CC=CC=C3)C(=O)O
CHEMBL7226 fpr1_human Human No 6.2 IC50 = 600 Funct
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
543 15 5 6 2.8 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)NCC2=CC=CC=C2
CHEMBL1770481 fpr1_human Human No 6.2 IC50 = 631.0 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
410 7 2 5 4.4 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CSC)C3=NC4=CC=CC=C4N3
CHEMBL1770481 fpr1_human Human No 6.2 IC50 = 631.0 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
410 7 2 5 4.4 CCOC1=CC2=C(C=C1)OC(=C2C)C(=O)NC(CSC)C3=NC4=CC=CC=C4N3
CHEMBL2372473 fpr1_human Human No 5.2 IC50 = 6300 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1274 20 6 13 7.7 CCC=CCC(C)C(C1C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)CCCCN)C)CC(C)C)C)C(C)C)CC(C)C)C)C)CC)O
CHEMBL1916273 fpr1_human Human No 5.2 IC50 = 6309.6 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
413 6 2 5 4.1 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C)C(=O)NC(C)C
CHEMBL1916258 fpr1_human Human No 5.2 IC50 = 6309.6 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
427 8 2 5 4.8 CCC(CC)NC(=O)C1=C(N(N=C1)C2=CC=CC=C2)NS(=O)(=O)C3=CC=CC=C3C
CHEMBL1934268 fpr1_human Human No 5.2 IC50 = 6309.6 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
407 7 2 5 4.1 CCN1C(=C(C(=N1)C)C(=O)NC(C)C(C)(C)C)NS(=O)(=O)C2=CC=C(C=C2)C
CHEMBL1770479 fpr1_human Human No 5.2 IC50 = 6309.6 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
392 7 2 4 4.2 CSCCC(C1=NC=C(N1)C2=CC=CC=C2)NC(=O)C3=C(C=CS3)Cl
CHEMBL1916273 fpr1_human Human No 5.2 IC50 = 6309.6 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
413 6 2 5 4.1 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C)C(=O)NC(C)C
CHEMBL1916258 fpr1_human Human No 5.2 IC50 = 6309.6 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
427 8 2 5 4.8 CCC(CC)NC(=O)C1=C(N(N=C1)C2=CC=CC=C2)NS(=O)(=O)C3=CC=CC=C3C
CHEMBL1934268 fpr1_human Human No 5.2 IC50 = 6309.6 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
407 7 2 5 4.1 CCN1C(=C(C(=N1)C)C(=O)NC(C)C(C)(C)C)NS(=O)(=O)C2=CC=C(C=C2)C
CHEMBL1770479 fpr1_human Human No 5.2 IC50 = 6309.6 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
392 7 2 4 4.2 CSCCC(C1=NC=C(N1)C2=CC=CC=C2)NC(=O)C3=C(C=CS3)Cl
CHEMBL2372476 fpr1_human Human No 5.2 IC50 = 6330 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1187 13 4 11 8.6 CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)CC2CCCCC2)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
CHEMBL2370885 fpr1_human Human No 5.2 IC50 = 6450 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1189 15 6 12 7.3 CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)NC(C(=O)N1)C(C(C)CC=CC)O)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
CHEMBL2372466 fpr1_human Human No 5.2 IC50 = 7000 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1217 16 5 12 8.0 CCC=CCC(C)C(C1C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)C(C)CC)C)C)CC)O
CHEMBL2372487 fpr1_human Human No 6.1 IC50 = 750 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1263 17 8 14 7.3 CCC(C)C1C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)N1)CC(C)C)C)C)C(C)O)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)CC(C)C)C)(C(C)C)O)C)CC(C)C)C
CHEMBL1916271 fpr1_human Human No 7.1 IC50 = 79.4 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
520 8 1 7 5.0 CCN(C1CCCCC1)C(=O)C2=C(N(N=C2)C3=CC=CC=C3)NS(=O)(=O)C4=CC=C(C=C4)C5=CN=CO5
CHEMBL1916282 fpr1_human Human No 7.1 IC50 = 79.4 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
455 7 2 5 5.5 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1916282 fpr1_human Human No 7.1 IC50 = 79.4 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
455 7 2 5 5.5 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1934414 fpr1_human Human No 7.1 IC50 = 79.4 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
447 7 2 5 5.0 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3CCCC3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1770300 fpr1_human Human No 7.1 IC50 = 79.4 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
402 5 3 3 5.5 CC1=C(C(=CC=C1)C(C(=O)NC2=C(C=CC=C2C)C)NC(=O)C3=CC=CC=C3O)C
CHEMBL1916271 fpr1_human Human No 7.1 IC50 = 79.4 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
520 8 1 7 5.0 CCN(C1CCCCC1)C(=O)C2=C(N(N=C2)C3=CC=CC=C3)NS(=O)(=O)C4=CC=C(C=C4)C5=CN=CO5
CHEMBL1916282 fpr1_human Human No 7.1 IC50 = 79.4 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
455 7 2 5 5.5 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1916282 fpr1_human Human No 7.1 IC50 = 79.4 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
455 7 2 5 5.5 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1934414 fpr1_human Human No 7.1 IC50 = 79.4 Funct
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
447 7 2 5 5.0 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3CCCC3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1770300 fpr1_human Human No 7.1 IC50 = 79.4 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
402 5 3 3 5.5 CC1=C(C(=CC=C1)C(C(=O)NC2=C(C=CC=C2C)C)NC(=O)C3=CC=CC=C3O)C
CHEMBL1916087 fpr1_human Human No 6.1 IC50 = 794.3 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
475 7 2 5 5.2 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=NN2C3=CC=CC=C3)C(=O)NCC4=C(C=C(C=C4)C)C
CHEMBL1916274 fpr1_human Human No 6.1 IC50 = 794.3 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
453 6 2 5 5.2 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C)C(=O)NC4CCCCC4
CHEMBL1770302 fpr1_human Human No 6.1 IC50 = 794.3 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
380 5 3 3 5.4 CC1=C(C(=CC=C1)C)NC(=O)C(C2CCCCC2)NC(=O)C3=CC=CC=C3O
CHEMBL1770299 fpr1_human Human Yes 6.1 IC50 = 794.3 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
409 5 3 3 5.4 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=C(C=C2)Cl)NC(=O)C3=CC=CC=C3O
CHEMBL1916087 fpr1_human Human No 6.1 IC50 = 794.3 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
475 7 2 5 5.2 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=NN2C3=CC=CC=C3)C(=O)NCC4=C(C=C(C=C4)C)C
CHEMBL1916274 fpr1_human Human No 6.1 IC50 = 794.3 Funct
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
453 6 2 5 5.2 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C)C(=O)NC4CCCCC4
CHEMBL1770302 fpr1_human Human No 6.1 IC50 = 794.3 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
380 5 3 3 5.4 CC1=C(C(=CC=C1)C)NC(=O)C(C2CCCCC2)NC(=O)C3=CC=CC=C3O
CHEMBL1770299 fpr1_human Human Yes 6.1 IC50 = 794.3 Funct
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
409 5 3 3 5.4 CC1=C(C(=CC=C1)C)NC(=O)C(C2=CC=C(C=C2)Cl)NC(=O)C3=CC=CC=C3O
CHEMBL6450 fpr1_human Human No 6.1 IC50 = 800 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
729 20 7 7 3.8 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)N
CHEMBL7226 fpr1_human Human No 6.1 IC50 = 800 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
543 15 5 6 2.8 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)NCC2=CC=CC=C2
CHEMBL6779 fpr1_human Human No 6.1 IC50 = 900 Funct
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
587 14 5 6 4.0 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)NC23CC4CC(C2)CC(C4)C3
CHEMBL2372485 fpr1_human Human No 5.0 IC50 = 9200 Funct
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
1189 15 6 12 7.3 CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
CHEMBL3311130 fpr1_human Human No 7.0 Kd = 100 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
782 23 6 9 6.2 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(COC(C)(C)C)NC(=O)OC(C)(C)C
CHEMBL3311130 fpr1_human Human No 7.0 Kd = 100 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
782 23 6 9 6.2 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(COC(C)(C)C)NC(=O)OC(C)(C)C
CHEMBL3311298 fpr1_human Human No 6.9 Kd = 120 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
925 24 6 10 8.7 CC(C)CC(C(=O)NC(CC1=CN(C2=CC=CC=C21)C(=O)OC(C)(C)C)C(=O)O)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=CC=C4)NC(=O)OC(C)(C)C
CHEMBL3311298 fpr1_human Human No 6.9 Kd = 120 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
925 24 6 10 8.7 CC(C)CC(C(=O)NC(CC1=CN(C2=CC=CC=C21)C(=O)OC(C)(C)C)C(=O)O)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=CC=C4)NC(=O)OC(C)(C)C
CHEMBL1916288 fpr1_human Human No 6.9 Kd = 125.9 Funct
Antagonist activity at FPR1 in whole blood assessed as CD11 levelAntagonist activity at FPR1 in whole blood assessed as CD11 level
484 7 2 7 5.0 CC1=NN(C(=C1C(=O)NC(C)C(C)(C)C)NS(=O)(=O)C2=CC=C(C=C2)C#N)C3=CC=C(C=C3)F
CHEMBL1916288 fpr1_human Human No 6.9 Kd = 125.9 Funct
Antagonist activity at FPR1 in whole blood assessed as CD11 levelAntagonist activity at FPR1 in whole blood assessed as CD11 level
484 7 2 7 5.0 CC1=NN(C(=C1C(=O)NC(C)C(C)(C)C)NS(=O)(=O)C2=CC=C(C=C2)C#N)C3=CC=C(C=C3)F
CHEMBL3311292 fpr1_human Human No 6.9 Kd = 130 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
752 22 6 8 6.3 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)OC(C)(C)C
CHEMBL3311294 fpr1_human Human No 6.9 Kd = 130 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
796 23 6 9 6.6 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(C(C)OC(C)(C)C)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)OC(C)(C)C
CHEMBL3311144 fpr1_human Human No 6.9 Kd = 130 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
770 23 6 9 5.7 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)OC(C)(C)C
CHEMBL3311292 fpr1_human Human No 6.9 Kd = 130 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
752 22 6 8 6.3 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)OC(C)(C)C
CHEMBL3311294 fpr1_human Human No 6.9 Kd = 130 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
796 23 6 9 6.6 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(C(C)OC(C)(C)C)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)OC(C)(C)C
CHEMBL3311144 fpr1_human Human No 6.9 Kd = 130 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
770 23 6 9 5.7 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)OC(C)(C)C
CHEMBL3311140 fpr1_human Human No 6.9 Kd = 140 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
871 26 7 9 7.4 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C(CCCCNC(=O)C3=CC=CC=C3)NC(=O)OC(C)(C)C
CHEMBL3311037 fpr1_human Human No 6.9 Kd = 140 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
796 23 6 9 6.6 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(C(C)OC(C)(C)C)NC(=O)OC(C)(C)C
CHEMBL3311140 fpr1_human Human No 6.9 Kd = 140 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
871 26 7 9 7.4 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C(CCCCNC(=O)C3=CC=CC=C3)NC(=O)OC(C)(C)C
CHEMBL3311037 fpr1_human Human No 6.9 Kd = 140 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
796 23 6 9 6.6 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(C(C)OC(C)(C)C)NC(=O)OC(C)(C)C
CHEMBL3311297 fpr1_human Human No 6.8 Kd = 150 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
825 22 7 8 6.1 CC(C)CC(C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)O)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=CC=C4)NC(=O)OC(C)(C)C
CHEMBL3311299 fpr1_human Human No 6.8 Kd = 150 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
890 24 6 9 8.0 CC(C)CC(C(=O)NC(CC1=CC=C(C=C1)C(=O)C2=CC=CC=C2)C(=O)O)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=CC=C4)NC(=O)OC(C)(C)C
CHEMBL3311139 fpr1_human Human No 6.8 Kd = 150 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
877 26 7 9 7.8 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C(CCCCNC(=O)C3CCCCC3)NC(=O)OC(C)(C)C
CHEMBL3311291 fpr1_human Human No 6.8 Kd = 150 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
890 24 6 9 8.0 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=C(C=C2)C(=O)C3=CC=CC=C3)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=CC=C4)NC(=O)OC(C)(C)C
CHEMBL3311297 fpr1_human Human No 6.8 Kd = 150 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
825 22 7 8 6.1 CC(C)CC(C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)O)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=CC=C4)NC(=O)OC(C)(C)C
CHEMBL3311299 fpr1_human Human No 6.8 Kd = 150 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
890 24 6 9 8.0 CC(C)CC(C(=O)NC(CC1=CC=C(C=C1)C(=O)C2=CC=CC=C2)C(=O)O)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=CC=C4)NC(=O)OC(C)(C)C
CHEMBL3311139 fpr1_human Human No 6.8 Kd = 150 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
877 26 7 9 7.8 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C(CCCCNC(=O)C3CCCCC3)NC(=O)OC(C)(C)C
CHEMBL3311291 fpr1_human Human No 6.8 Kd = 150 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
890 24 6 9 8.0 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=C(C=C2)C(=O)C3=CC=CC=C3)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=CC=C4)NC(=O)OC(C)(C)C
CHEMBL3311137 fpr1_human Human No 7.8 Kd = 16 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
890 24 6 9 8.0 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=C(C=C3)C(=O)C4=CC=CC=C4)NC(=O)OC(C)(C)C
CHEMBL3311137 fpr1_human Human No 7.8 Kd = 16 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
890 24 6 9 8.0 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=C(C=C3)C(=O)C4=CC=CC=C4)NC(=O)OC(C)(C)C
CHEMBL3311031 fpr1_human Human No 6.8 Kd = 170 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
710 20 6 8 4.3 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C(C)NC(=O)OC(C)(C)C
CHEMBL3311031 fpr1_human Human No 6.8 Kd = 170 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
710 20 6 8 4.3 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C(C)NC(=O)OC(C)(C)C
CHEMBL3311293 fpr1_human Human No 6.8 Kd = 180 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
782 23 6 9 6.2 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(COC(C)(C)C)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)OC(C)(C)C
CHEMBL3311293 fpr1_human Human No 6.8 Kd = 180 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
782 23 6 9 6.2 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(COC(C)(C)C)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)OC(C)(C)C
CHEMBL1934424 fpr1_human Human No 7.7 Kd = 20.0 Funct
Antagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometryAntagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometry
491 8 2 6 4.9 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3CCC(CC3)OC)C)C(=O)NC(C)C(C)(C)C
CHEMBL1934424 fpr1_human Human No 7.7 Kd = 20.0 Funct
Antagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometryAntagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometry
491 8 2 6 4.9 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3CCC(CC3)OC)C)C(=O)NC(C)C(C)(C)C
CHEMBL3311134 fpr1_human Human No 6.7 Kd = 190 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
825 22 7 8 6.1 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)OC(C)(C)C
CHEMBL3311134 fpr1_human Human No 6.7 Kd = 190 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
825 22 7 8 6.1 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)OC(C)(C)C
CHEMBL3311300 fpr1_human Human No 8.7 Kd = 2.1 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
894 24 6 9 8.8 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CCCCC2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=C(C=C3)C(=O)C4=CC=CC=C4)NC(=O)OC(C)(C)C
CHEMBL3311300 fpr1_human Human No 8.7 Kd = 2.1 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
894 24 6 9 8.8 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CCCCC2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=C(C=C3)C(=O)C4=CC=CC=C4)NC(=O)OC(C)(C)C
CHEMBL3311142 fpr1_human Human No 6.7 Kd = 200 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
752 22 6 8 6.3 CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)OC(C)(C)C
CHEMBL3311036 fpr1_human Human No 6.7 Kd = 200 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
752 22 6 8 6.3 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OC(C)(C)C
CHEMBL3311142 fpr1_human Human No 6.7 Kd = 200 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
752 22 6 8 6.3 CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)OC(C)(C)C
CHEMBL3311036 fpr1_human Human No 6.7 Kd = 200 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
752 22 6 8 6.3 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OC(C)(C)C
CHEMBL3311030 fpr1_human Human Yes 6.6 Kd = 230 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
786 22 6 8 6.6 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)OC(C)(C)C
CHEMBL3311030 fpr1_human Human Yes 6.6 Kd = 230 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
786 22 6 8 6.6 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)OC(C)(C)C
CHEMBL3311143 fpr1_human Human No 7.6 Kd = 25 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
792 22 6 8 7.8 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2CCCCC2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)OC(C)(C)C
CHEMBL3311143 fpr1_human Human No 7.6 Kd = 25 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
792 22 6 8 7.8 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2CCCCC2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)OC(C)(C)C
CHEMBL3311032 fpr1_human Human No 6.6 Kd = 260 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
744 20 6 8 4.5 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(C)NC(=O)C(CC3=CC=CC=C3)NC(=O)OC(C)(C)C
CHEMBL3309281 fpr1_human Human No 6.6 Kd = 260 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
738 21 6 8 6.4 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)OC(C)(C)C
CHEMBL3311032 fpr1_human Human No 6.6 Kd = 260 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
744 20 6 8 4.5 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(C)NC(=O)C(CC3=CC=CC=C3)NC(=O)OC(C)(C)C
CHEMBL3309281 fpr1_human Human No 6.6 Kd = 260 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
738 21 6 8 6.4 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)OC(C)(C)C
CHEMBL3311033 fpr1_human Human No 6.6 Kd = 280 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
710 20 6 8 4.3 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)OC(C)(C)C
CHEMBL3311033 fpr1_human Human No 6.6 Kd = 280 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
710 20 6 8 4.3 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)OC(C)(C)C
CHEMBL267179 fpr1_human Human Yes 8.5 Kd = 3 Funct
Binding affinity to human FPR1 receptorBinding affinity to human FPR1 receptor
None None None CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC=O
CHEMBL267179 fpr1_human Human Yes 8.5 Kd = 3 Funct
Binding affinity to human FPR1 receptorBinding affinity to human FPR1 receptor
None None None CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC=O
CHEMBL3311035 fpr1_human Human No 6.5 Kd = 350 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
710 20 6 8 5.0 CC(C)CC(C(=O)NC(C)C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)OC(C)(C)C
CHEMBL3311035 fpr1_human Human No 6.5 Kd = 350 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
710 20 6 8 5.0 CC(C)CC(C(=O)NC(C)C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)OC(C)(C)C
CHEMBL1916282 fpr1_human Human No 6.4 Kd = 398.1 Funct
Antagonist activity at FPR1 in whole blood assessed as CD11 levelAntagonist activity at FPR1 in whole blood assessed as CD11 level
455 7 2 5 5.5 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C)C(=O)NC(C)C(C)(C)C
CHEMBL1916282 fpr1_human Human No 6.4 Kd = 398.1 Funct
Antagonist activity at FPR1 in whole blood assessed as CD11 levelAntagonist activity at FPR1 in whole blood assessed as CD11 level
455 7 2 5 5.5 CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NN2C3=CC=CC=C3)C)C(=O)NC(C)C(C)(C)C
CHEMBL3311034 fpr1_human Human No 6.4 Kd = 420 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
744 20 6 8 4.5 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C)C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C(CC3=CC=CC=C3)NC(=O)OC(C)(C)C
CHEMBL3311034 fpr1_human Human No 6.4 Kd = 420 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
744 20 6 8 4.5 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C)C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C(CC3=CC=CC=C3)NC(=O)OC(C)(C)C
CHEMBL3311289 fpr1_human Human No 6.3 Kd = 510 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
810 24 6 10 6.2 CC(C)CC(C(=O)NC(CC(=O)OC(C)(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)OC(C)(C)C
CHEMBL3311289 fpr1_human Human No 6.3 Kd = 510 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
810 24 6 10 6.2 CC(C)CC(C(=O)NC(CC(=O)OC(C)(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)OC(C)(C)C
CHEMBL3311301 fpr1_human Human No 8.2 Kd = 6.9 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
900 24 6 9 9.9 CC(C)CC(C(=O)NC(CC1CCCCC1)C(=O)O)NC(=O)C(CC2=CCCCC2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=C(C=C3)C(=O)C4=CC=CC=C4)NC(=O)OC(C)(C)C
CHEMBL3311301 fpr1_human Human No 8.2 Kd = 6.9 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
900 24 6 9 9.9 CC(C)CC(C(=O)NC(CC1CCCCC1)C(=O)O)NC(=O)C(CC2=CCCCC2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=C(C=C3)C(=O)C4=CC=CC=C4)NC(=O)OC(C)(C)C
CHEMBL3311133 fpr1_human Human No 7.2 Kd = 62 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
858 24 6 9 7.6 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=C(C=C3)OC(C)(C)C)NC(=O)OC(C)(C)C
CHEMBL3311133 fpr1_human Human No 7.2 Kd = 62 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
858 24 6 9 7.6 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=C(C=C3)OC(C)(C)C)NC(=O)OC(C)(C)C
CHEMBL3311131 fpr1_human Human No 7.2 Kd = 66 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
792 22 6 8 7.8 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C(CC3CCCCC3)NC(=O)OC(C)(C)C
CHEMBL3311131 fpr1_human Human No 7.2 Kd = 66 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
792 22 6 8 7.8 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C(CC3CCCCC3)NC(=O)OC(C)(C)C
CHEMBL3311296 fpr1_human Human No 7.2 Kd = 68 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
858 24 6 9 7.6 CC(C)CC(C(=O)NC(CC1=CC=C(C=C1)OC(C)(C)C)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)OC(C)(C)C
CHEMBL3311296 fpr1_human Human No 7.2 Kd = 68 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
858 24 6 9 7.6 CC(C)CC(C(=O)NC(CC1=CC=C(C=C1)OC(C)(C)C)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)OC(C)(C)C
CHEMBL3311136 fpr1_human Human No 7.2 Kd = 69 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
925 24 6 10 8.7 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CN(C4=CC=CC=C43)C(=O)OC(C)(C)C)NC(=O)OC(C)(C)C
CHEMBL3311136 fpr1_human Human No 7.2 Kd = 69 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
925 24 6 10 8.7 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CN(C4=CC=CC=C43)C(=O)OC(C)(C)C)NC(=O)OC(C)(C)C
CHEMBL3311138 fpr1_human Human No 6.1 Kd = 730 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
767 24 7 9 2.5 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C(CCCCN)NC(=O)OC(C)(C)C
CHEMBL3311138 fpr1_human Human No 6.1 Kd = 730 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
767 24 7 9 2.5 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C(CCCCN)NC(=O)OC(C)(C)C
CHEMBL3311132 fpr1_human Human No 7.1 Kd = 75 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
820 22 6 8 7.2 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)OC(C)(C)C
CHEMBL3311132 fpr1_human Human No 7.1 Kd = 75 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
820 22 6 8 7.2 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)OC(C)(C)C
CHEMBL3311295 fpr1_human Human No 7.1 Kd = 77 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
792 22 6 8 8.5 CC(C)CC(C(=O)NC(CC1CCCCC1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)OC(C)(C)C
CHEMBL3311295 fpr1_human Human No 7.1 Kd = 77 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
792 22 6 8 8.5 CC(C)CC(C(=O)NC(CC1CCCCC1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)OC(C)(C)C
CHEMBL1934426 fpr1_human Human No 6.1 Kd = 794.3 Funct
Antagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometryAntagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometry
489 8 2 6 4.7 CC1=NN(C(=C1C(=O)NC(C)C(C)(C)C)NS(=O)(=O)C2=CC=C(C=C2)C3CC3)C4CCOCC4
CHEMBL1934426 fpr1_human Human No 6.1 Kd = 794.3 Funct
Antagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometryAntagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometry
489 8 2 6 4.7 CC1=NN(C(=C1C(=O)NC(C)C(C)(C)C)NS(=O)(=O)C2=CC=C(C=C2)C3CC3)C4CCOCC4
CHEMBL3311288 fpr1_human Human No 6.1 Kd = 830 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
796 23 6 9 6.6 CC(C)CC(C(=O)NC(C(C)OC(C)(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)OC(C)(C)C
CHEMBL3311288 fpr1_human Human No 6.1 Kd = 830 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
796 23 6 9 6.6 CC(C)CC(C(=O)NC(C(C)OC(C)(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)OC(C)(C)C
CHEMBL3311135 fpr1_human Human No 7.1 Kd = 90 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
853 22 6 9 7.3 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CN(C4=CC=CC=C43)C=O)NC(=O)OC(C)(C)C
CHEMBL3311135 fpr1_human Human No 7.1 Kd = 90 Funct
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
853 22 6 9 7.3 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CC3=CN(C4=CC=CC=C43)C=O)NC(=O)OC(C)(C)C
CHEMBL1329101 fpr1_human Human Yes 7.0 Ki = 100 Funct
Antagonist activity at FPR1Antagonist activity at FPR1
376 4 0 5 3.7 CCC1=C(C=C2C(=C1)C(=O)C(=C(O2)C)C3=NC4=CC=CC=C4N3C)OC(=O)C
CHEMBL1329101 fpr1_human Human Yes 7.0 Ki = 100 Funct
Antagonist activity at FPR1Antagonist activity at FPR1
376 4 0 5 3.7 CCC1=C(C=C2C(=C1)C(=O)C(=C(O2)C)C3=NC4=CC=CC=C4N3C)OC(=O)C
CHEMBL267179 fpr1_human Human Yes 7.4 Ki = 42 Funct
Displacement of [3H]-fMLP from FPR in human neutrophilsDisplacement of [3H]-fMLP from FPR in human neutrophils
None None None CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC=O
CHEMBL267179 fpr1_human Human Yes 7.4 Ki = 42 Funct
Displacement of [3H]-fMLP from FPR in human neutrophilsDisplacement of [3H]-fMLP from FPR in human neutrophils
None None None CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC=O
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polymorphic Polymorphic 2.0.3
rest_framework Django REST framework 3.9.3
rest_framework_swagger Rest_Framework_Swagger 2.2.0

Time

Resource usage

Resource Value
User CPU time 2062.542 msec
System CPU time 166.028 msec
Total CPU time 2228.570 msec
Elapsed time 2576.972 msec
Context switches 454 voluntary, 101 involuntary

Browser timing

Timing attribute Timeline Milliseconds since navigation start (+length)

Settings from protwis.settings

Setting Value
ABSOLUTE_URL_OVERRIDES {}
ADMINS []
ALLOWED_HOSTS ['*']
APPEND_SLASH True
AUTHENTICATION_BACKENDS ['django.contrib.auth.backends.ModelBackend']
AUTH_PASSWORD_VALIDATORS '********************'
AUTH_USER_MODEL 'auth.User'
BASE_DIR '/home/protwis/gpcrdb_test'
BUILD_CACHE_DIR '/home/protwis/gpcrdb_data/cache'
CACHES {'alignments': {'BACKEND': 'django.core.cache.backends.filebased.FileBasedCache', 'LOCATION': '/home/protwis/caches/test_alignment', 'OPTIONS': {'MAX_ENTRIES': 1000}}, 'default': {'BACKEND': 'django.core.cache.backends.filebased.FileBasedCache', 'LOCATION': '/home/protwis/caches/test/', 'OPTIONS': {'MAX_ENTRIES': 10000000}}}
CACHE_MIDDLEWARE_ALIAS 'default'
CACHE_MIDDLEWARE_KEY_PREFIX '********************'
CACHE_MIDDLEWARE_SECONDS 600
CSRF_COOKIE_AGE 31449600
CSRF_COOKIE_DOMAIN None
CSRF_COOKIE_HTTPONLY False
CSRF_COOKIE_NAME 'csrftoken'
CSRF_COOKIE_PATH '/'
CSRF_COOKIE_SAMESITE 'Lax'
CSRF_COOKIE_SECURE False
CSRF_FAILURE_VIEW 'django.views.csrf.csrf_failure'
CSRF_HEADER_NAME 'HTTP_X_CSRFTOKEN'
CSRF_TRUSTED_ORIGINS []
CSRF_USE_SESSIONS False
DATABASES {'default': {'ATOMIC_REQUESTS': False, 'AUTOCOMMIT': True, 'CONN_MAX_AGE': 0, 'ENGINE': 'django.db.backends.postgresql_psycopg2', 'HOST': 'localhost', 'NAME': 'protwis_202107', 'OPTIONS': {}, 'PASSWORD': '********************', 'PORT': '', 'TEST': {'CHARSET': None, 'COLLATION': None, 'MIRROR': None, 'NAME': None}, 'TIME_ZONE': None, 'USER': 'protwis'}}
DATABASE_ROUTERS []
DATA_DIR '/home/protwis/gpcrdb_data'
DATA_UPLOAD_MAX_MEMORY_SIZE 2621440
DATA_UPLOAD_MAX_NUMBER_FIELDS 1000
DATETIME_FORMAT 'N j, Y, P'
DATETIME_INPUT_FORMATS ['%Y-%m-%d %H:%M:%S', '%Y-%m-%d %H:%M:%S.%f', '%Y-%m-%d %H:%M', '%Y-%m-%d', '%m/%d/%Y %H:%M:%S', '%m/%d/%Y %H:%M:%S.%f', '%m/%d/%Y %H:%M', '%m/%d/%Y', '%m/%d/%y %H:%M:%S', '%m/%d/%y %H:%M:%S.%f', '%m/%d/%y %H:%M', '%m/%d/%y']
DATE_FORMAT 'N j, Y'
DATE_INPUT_FORMATS ['%Y-%m-%d', '%m/%d/%Y', '%m/%d/%y', '%b %d %Y', '%b %d, %Y', '%d %b %Y', '%d %b, %Y', '%B %d %Y', '%B %d, %Y', '%d %B %Y', '%d %B, %Y']
DEBUG True
DEBUG_PROPAGATE_EXCEPTIONS False
DEBUG_TOOLBAR_PATCH_SETTINGS False
DECIMAL_SEPARATOR '.'
DEFAULT_CHARSET 'utf-8'
DEFAULT_CONTENT_TYPE 'text/html'
DEFAULT_EXCEPTION_REPORTER_FILTER 'django.views.debug.SafeExceptionReporterFilter'
DEFAULT_FILE_STORAGE 'django.core.files.storage.FileSystemStorage'
DEFAULT_FROM_EMAIL 'webmaster@localhost'
DEFAULT_INDEX_TABLESPACE ''
DEFAULT_NUMBERING_SCHEME 'gpcrdb'
DEFAULT_PROTEIN_STATE 'inactive'
DEFAULT_SITE 'gpcr'
DEFAULT_TABLESPACE ''
DISALLOWED_USER_AGENTS []
DOCUMENTATION_URL 'https://docs.gpcrdb.org/'
EMAIL_BACKEND 'django.core.mail.backends.smtp.EmailBackend'
EMAIL_HOST 'localhost'
EMAIL_HOST_PASSWORD '********************'
EMAIL_HOST_USER ''
EMAIL_PORT 25
EMAIL_SSL_CERTFILE None
EMAIL_SSL_KEYFILE '********************'
EMAIL_SUBJECT_PREFIX '[Django] '
EMAIL_TIMEOUT None
EMAIL_USE_LOCALTIME False
EMAIL_USE_SSL False
EMAIL_USE_TLS False
FILE_CHARSET 'utf-8'
FILE_UPLOAD_DIRECTORY_PERMISSIONS None
FILE_UPLOAD_HANDLERS ['django.core.files.uploadhandler.MemoryFileUploadHandler', 'django.core.files.uploadhandler.TemporaryFileUploadHandler']
FILE_UPLOAD_MAX_MEMORY_SIZE 2621440
FILE_UPLOAD_PERMISSIONS None
FILE_UPLOAD_TEMP_DIR None
FIRST_DAY_OF_WEEK 0
FIXTURE_DIRS []
FORCE_SCRIPT_NAME None
FORMAT_MODULE_PATH None
FORM_RENDERER 'django.forms.renderers.DjangoTemplates'
GOOGLE_ANALYTICS_API '********************'
GOOGLE_ANALYTICS_KEY '********************'
IGNORABLE_404_URLS []
INSTALLED_APPS ('django.contrib.admin', 'django.contrib.auth', 'django.contrib.contenttypes', 'django.contrib.sessions', 'django.contrib.messages', 'django.contrib.staticfiles', 'django.contrib.humanize', 'debug_toolbar', 'rest_framework', 'rest_framework_swagger', 'polymorphic', 'common', 'api', 'news', 'pages', 'home', 'protein', 'family', 'residue', 'alignment', 'similaritysearch', 'similaritymatrix', 'structure', 'ligand', 'interaction', 'mutation', 'phylogenetic_trees', 'sitesearch', 'build_gpcr', 'construct', 'tools', 'drugs', 'signprot', 'signprot2', 'mutational_landscape', 'contactnetwork', 'seqsign', 'angles', 'hotspots')
INTERNAL_IPS '10.0.2.2'
LANGUAGES [('af', 'Afrikaans'), ('ar', 'Arabic'), ('ast', 'Asturian'), ('az', 'Azerbaijani'), ('bg', 'Bulgarian'), ('be', 'Belarusian'), ('bn', 'Bengali'), ('br', 'Breton'), ('bs', 'Bosnian'), ('ca', 'Catalan'), ('cs', 'Czech'), ('cy', 'Welsh'), ('da', 'Danish'), ('de', 'German'), ('dsb', 'Lower Sorbian'), ('el', 'Greek'), ('en', 'English'), ('en-au', 'Australian English'), ('en-gb', 'British English'), ('eo', 'Esperanto'), ('es', 'Spanish'), ('es-ar', 'Argentinian Spanish'), ('es-co', 'Colombian Spanish'), ('es-mx', 'Mexican Spanish'), ('es-ni', 'Nicaraguan Spanish'), ('es-ve', 'Venezuelan Spanish'), ('et', 'Estonian'), ('eu', 'Basque'), ('fa', 'Persian'), ('fi', 'Finnish'), ('fr', 'French'), ('fy', 'Frisian'), ('ga', 'Irish'), ('gd', 'Scottish Gaelic'), ('gl', 'Galician'), ('he', 'Hebrew'), ('hi', 'Hindi'), ('hr', 'Croatian'), ('hsb', 'Upper Sorbian'), ('hu', 'Hungarian'), ('hy', 'Armenian'), ('ia', 'Interlingua'), ('id', 'Indonesian'), ('io', 'Ido'), ('is', 'Icelandic'), ('it', 'Italian'), ('ja', 'Japanese'), ('ka', 'Georgian'), ('kab', 'Kabyle'), ('kk', 'Kazakh'), ('km', 'Khmer'), ('kn', 'Kannada'), ('ko', 'Korean'), ('lb', 'Luxembourgish'), ('lt', 'Lithuanian'), ('lv', 'Latvian'), ('mk', 'Macedonian'), ('ml', 'Malayalam'), ('mn', 'Mongolian'), ('mr', 'Marathi'), ('my', 'Burmese'), ('nb', 'Norwegian Bokmål'), ('ne', 'Nepali'), ('nl', 'Dutch'), ('nn', 'Norwegian Nynorsk'), ('os', 'Ossetic'), ('pa', 'Punjabi'), ('pl', 'Polish'), ('pt', 'Portuguese'), ('pt-br', 'Brazilian Portuguese'), ('ro', 'Romanian'), ('ru', 'Russian'), ('sk', 'Slovak'), ('sl', 'Slovenian'), ('sq', 'Albanian'), ('sr', 'Serbian'), ('sr-latn', 'Serbian Latin'), ('sv', 'Swedish'), ('sw', 'Swahili'), ('ta', 'Tamil'), ('te', 'Telugu'), ('th', 'Thai'), ('tr', 'Turkish'), ('tt', 'Tatar'), ('udm', 'Udmurt'), ('uk', 'Ukrainian'), ('ur', 'Urdu'), ('vi', 'Vietnamese'), ('zh-hans', 'Simplified Chinese'), ('zh-hant', 'Traditional Chinese')]
LANGUAGES_BIDI ['he', 'ar', 'fa', 'ur']
LANGUAGE_CODE 'en-us'
LANGUAGE_COOKIE_AGE None
LANGUAGE_COOKIE_DOMAIN None
LANGUAGE_COOKIE_NAME 'django_language'
LANGUAGE_COOKIE_PATH '/'
LOCALE_PATHS []
LOGGING {'disable_existing_loggers': False, 'formatters': {'verbose': {'datefmt': '%d/%b/%Y %H:%M:%S', 'format': '[%(asctime)s] %(levelname)s ' '[%(name)s:%(lineno)s] %(message)s'}, 'verbose_low': {'datefmt': '%d/%b/%Y %H:%M:%S', 'format': '[%(asctime)s] %(levelname)s ' '[%(name)s:%(lineno)s]'}}, 'handlers': {'build': {'class': 'logging.FileHandler', 'filename': 'logs/build.log', 'formatter': 'verbose', 'level': 'DEBUG'}, 'django': {'class': 'logging.FileHandler', 'filename': 'logs/django.log', 'formatter': 'verbose', 'level': 'WARNING'}, 'protwis': {'class': 'logging.FileHandler', 'filename': 'logs/protwis.log', 'formatter': 'verbose', 'level': 'DEBUG'}}, 'loggers': {'build': {'handlers': ['build'], 'level': 'DEBUG'}, 'django': {'handlers': ['django'], 'level': 'WARNING', 'propagate': True}, 'protwis': {'handlers': ['protwis'], 'level': 'DEBUG'}}, 'version': 1}
LOGGING_CONFIG 'logging.config.dictConfig'
LOGIN_REDIRECT_URL '/accounts/profile/'
LOGIN_URL '/accounts/login/'
LOGOUT_REDIRECT_URL None
MANAGERS []
MEDIA_ROOT '/protwis/media/protwis'
MEDIA_URL '/media/'
MESSAGE_STORAGE 'django.contrib.messages.storage.fallback.FallbackStorage'
MIDDLEWARE ('common.middleware.stats.StatsMiddleware', 'debug_toolbar.middleware.DebugToolbarMiddleware', 'django.contrib.sessions.middleware.SessionMiddleware', 'django.middleware.common.CommonMiddleware', 'django.middleware.csrf.CsrfViewMiddleware', 'django.contrib.auth.middleware.AuthenticationMiddleware', 'django.contrib.messages.middleware.MessageMiddleware', 'django.middleware.clickjacking.XFrameOptionsMiddleware')
MIGRATION_MODULES {}
MONTH_DAY_FORMAT 'F j'
NUMBER_GROUPING 0
PASSWORD_HASHERS '********************'
PASSWORD_RESET_TIMEOUT_DAYS '********************'
PREPEND_WWW False
REFERENCE_POSITIONS {'D1S1': 'D1S1x50', 'D1S2': 'D1S2x50', 'D1T1': 'D1T1x50', 'D1e1': 'D1e1x50', 'ECL1': '23x50', 'ECL2': '45x50', 'H8': '8x50', 'ICL1': '12x50', 'ICL2': '34x50', 'TM1': '1x50', 'TM2': '2x50', 'TM3': '3x50', 'TM4': '4x50', 'TM5': '5x50', 'TM6': '6x50', 'TM7': '7x50'}
ROOT_URLCONF 'protwis.urls'
SECRET_KEY '********************'
SECURE_BROWSER_XSS_FILTER False
SECURE_CONTENT_TYPE_NOSNIFF False
SECURE_HSTS_INCLUDE_SUBDOMAINS False
SECURE_HSTS_PRELOAD False
SECURE_HSTS_SECONDS 0
SECURE_PROXY_SSL_HEADER None
SECURE_REDIRECT_EXEMPT []
SECURE_SSL_HOST None
SECURE_SSL_REDIRECT False
SERVER_EMAIL 'root@localhost'
SESSION_CACHE_ALIAS 'default'
SESSION_COOKIE_AGE 86400
SESSION_COOKIE_DOMAIN None
SESSION_COOKIE_HTTPONLY True
SESSION_COOKIE_NAME 'sessionid'
SESSION_COOKIE_PATH '/'
SESSION_COOKIE_SAMESITE 'Lax'
SESSION_COOKIE_SECURE False
SESSION_ENGINE 'django.contrib.sessions.backends.db'
SESSION_EXPIRE_AT_BROWSER_CLOSE False
SESSION_FILE_PATH None
SESSION_SAVE_EVERY_REQUEST False
SESSION_SERIALIZER 'django.contrib.sessions.serializers.PickleSerializer'
SETTINGS_MODULE 'protwis.settings'
SHORT_DATETIME_FORMAT 'm/d/Y P'
SHORT_DATE_FORMAT 'm/d/Y'
SIGNING_BACKEND 'django.core.signing.TimestampSigner'
SILENCED_SYSTEM_CHECKS []
SITE_NAME 'gpcr'
SITE_TITLE 'GPCRdb'
STATICFILES_DIRS ('/home/protwis/gpcrdb_test/static',)
STATICFILES_FINDERS ['django.contrib.staticfiles.finders.FileSystemFinder', 'django.contrib.staticfiles.finders.AppDirectoriesFinder']
STATICFILES_STORAGE 'django.contrib.staticfiles.storage.StaticFilesStorage'
STATIC_ROOT '/home/protwis/static_test/'
STATIC_URL '/static/'
SWAGGER_SETTINGS {'USE_SESSION_AUTH': False}
TEMPLATES [{'APP_DIRS': True, 'BACKEND': 'django.template.backends.django.DjangoTemplates', 'DIRS': [], 'OPTIONS': {'context_processors': ['django.contrib.auth.context_processors.auth', 'django.template.context_processors.debug', 'django.template.context_processors.i18n', 'django.template.context_processors.media', 'django.template.context_processors.static', 'django.template.context_processors.tz', 'django.contrib.messages.context_processors.messages', 'protwis.context_processors.current_site', 'protwis.context_processors.canonical_tag', 'protwis.context_processors.documentation_url', 'protwis.context_processors.google_analytics', 'protwis.context_processors.site_title'], 'debug': True}}]
TEST_NON_SERIALIZED_APPS []
TEST_RUNNER 'django.test.runner.DiscoverRunner'
THOUSAND_SEPARATOR ','
TIME_FORMAT 'P'
TIME_INPUT_FORMATS ['%H:%M:%S', '%H:%M:%S.%f', '%H:%M']
TIME_ZONE 'Europe/Copenhagen'
USE_I18N True
USE_L10N True
USE_THOUSAND_SEPARATOR False
USE_TZ True
USE_X_FORWARDED_HOST False
USE_X_FORWARDED_PORT False
WSGI_APPLICATION None
X_FRAME_OPTIONS 'SAMEORIGIN'
YEAR_MONTH_FORMAT 'F Y'

Headers

Request headers

Key Value
Accept text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8
Accept-Encoding br,gzip
Accept-Language en-US,en;q=0.5
Connection close
Host test.gpcrdb.org
User-Agent CCBot/2.0 (https://commoncrawl.org/faq/)
X-Forwarded-For 35.168.110.128
X-Forwarded-Proto https
X-Real-Ip 35.168.110.128

Response headers

Key Value
Content-Length 691313
Content-Type text/html; charset=utf-8
Vary Cookie
X-Frame-Options SAMEORIGIN

WSGI environ

Since the WSGI environ inherits the environment of the server, only a significant subset is shown below.

Key Value
PATH_INFO /ligand/target/all/001_002_008_001/
QUERY_STRING
REMOTE_ADDR
REQUEST_METHOD GET
SCRIPT_NAME
SERVER_NAME test.gpcrdb.org
SERVER_PORT 443
SERVER_PROTOCOL HTTP/1.0
SERVER_SOFTWARE gunicorn/19.9.0

Request

View information

View function Arguments Keyword arguments URL name
ligand.views.TargetDetails () {'slug': '001_002_008_001'} ligand_target_detail

No cookies

No session data

No GET data

No POST data

SQL queries from 1 connection

  •   default 400.90 ms (470 queries including 468 similar and 422 duplicates )
  Query Timeline Time (ms) Action
  +
SELECT ••• "ligand_assayexperiment"."id", "ligand_assayexperiment"."ligand_id", "ligand_assayexperiment"."protein_id", "ligand_assayexperiment"."assay_id", "ligand_assayexperiment"."assay_type", "ligand_assayexperiment"."assay_description", "ligand_assayexperiment"."pchembl_value", "ligand_assayexperiment"."published_value", "ligand_assayexperiment"."published_relation", "ligand_assayexperiment"."published_type", "ligand_assayexperiment"."published_units", "ligand_assayexperiment"."standard_value", "ligand_assayexperiment"."standard_relation", "ligand_assayexperiment"."standard_type", "ligand_assayexperiment"."standard_units", "ligand_assayexperiment"."publication_id", "ligand_assayexperiment"."chembl", "ligand_assayexperiment"."smiles", "ligand_assayexperiment"."activity", "ligand_assayexperiment"."document_chembl_id", "ligand_assayexperiment"."cell_line" FROM "ligand_assayexperiment" INNER JOIN "ligand" ON ("ligand_assayexperiment"."ligand_id" = "ligand"."id") INNER JOIN "ligand_properities" ON ("ligand"."properities_id" = "ligand_properities"."id") INNER JOIN "ligand_properities_web_links" ON ("ligand_properities"."id" = "ligand_properities_web_links"."ligandproperities_id") INNER JOIN "web_link" ON ("ligand_properities_web_links"."weblink_id" = "web_link"."id") INNER JOIN "web_resource" ON ("web_link"."web_resource_id" = "web_resource"."id") INNER JOIN "protein" ON ("ligand_assayexperiment"."protein_id" = "protein"."id") INNER JOIN "protein_family" ON ("protein"."family_id" = "protein_family"."id") WHERE ("web_resource"."slug" = 'chembl_ligand' AND "protein_family"."slug" = '001_002_008_001')
19.40913013303106%
 77.81

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(334)
  if not ps:
  +
SELECT ••• "ligand_assayexperiment"."standard_type", "ligand_assayexperiment"."standard_relation", "ligand_assayexperiment"."standard_value", "ligand_assayexperiment"."assay_description", "ligand_assayexperiment"."assay_type", "ligand_assayexperiment"."pchembl_value", "ligand_assayexperiment"."ligand_id", "ligand"."properities_id", "web_link"."index", "species"."common_name", "protein"."entry_name", "ligand_properities"."mw", "ligand_properities"."logp", "ligand_properities"."rotatable_bonds", "ligand_properities"."smiles", "ligand_properities"."hdon", "ligand_properities"."hacc", "ligand_assayexperiment"."protein_id", COUNT(DISTINCT "ligand_assayexperiment"."protein_id") AS "num_targets" FROM "ligand_assayexperiment" INNER JOIN "ligand" ON ("ligand_assayexperiment"."ligand_id" = "ligand"."id") INNER JOIN "ligand_properities" ON ("ligand"."properities_id" = "ligand_properities"."id") INNER JOIN "ligand_properities_web_links" ON ("ligand_properities"."id" = "ligand_properities_web_links"."ligandproperities_id") INNER JOIN "web_link" ON ("ligand_properities_web_links"."weblink_id" = "web_link"."id") INNER JOIN "web_resource" ON ("web_link"."web_resource_id" = "web_resource"."id") INNER JOIN "protein" ON ("ligand_assayexperiment"."protein_id" = "protein"."id") INNER JOIN "protein_family" ON ("protein"."family_id" = "protein_family"."id") INNER JOIN "species" ON ("protein"."species_id" = "species"."id") WHERE ("web_resource"."slug" = 'chembl_ligand' AND "protein_family"."slug" = '001_002_008_001') GROUP BY "ligand_assayexperiment"."standard_type", "ligand_assayexperiment"."standard_relation", "ligand_assayexperiment"."standard_value", "ligand_assayexperiment"."assay_description", "ligand_assayexperiment"."assay_type", "ligand_assayexperiment"."pchembl_value", "ligand_assayexperiment"."ligand_id", "ligand"."properities_id", "web_link"."index", "species"."common_name", "protein"."entry_name", "ligand_properities"."mw", "ligand_properities"."logp", "ligand_properities"."rotatable_bonds", "ligand_properities"."smiles", "ligand_properities"."hdon", "ligand_properities"."hacc", "ligand_assayexperiment"."protein_id"
3.440347739827902%
 13.79

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(357)
  for record in ps:
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 91744 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 2 times.
0.23175915127503216%
 0.93

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 142935 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 2 times.
0.13339383533741267%
 0.53

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 1836 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 8 times.
0.1351184992806962%
 0.54

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 1836 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 8 times.
0.13042027681451002%
 0.52

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 137602 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 2 times.
0.368721256839928%
 1.48

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 87119 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.
0.1301823921326778%
 0.52

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 137602 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 2 times.
0.11971546613206051%
 0.48

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 86507 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.
0.1239973904050403%
 0.50

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 137484 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.1282793146780201%
 0.51

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 137484 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.1276846029734396%
 0.51

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 137484 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.119180225597938%
 0.48

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 137484 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.12227272646175677%
 0.49

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 86347 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.
0.12488945796191109%
 0.50

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 138282 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.13214494075779354%
 0.53

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 138282 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.12697094892794294%
 0.51

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 138282 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.12744671829160736%
 0.51

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 138282 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.12649517956427853%
 0.51

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 21477 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.
0.3826375107271124%
 1.53

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 88399 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.
0.3416024031110559%
 1.37

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 88493 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.
0.35694596508923354%
 1.43

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 137841 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.344040721099836%
 1.38

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 137841 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.1241163327459564%
 0.50

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 67726 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 4 times.
0.44103820011692035%
 1.77

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 67726 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 4 times.
0.12352162104137589%
 0.50

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 19454 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.5033045155865017%
 2.02

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 19454 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.11953705262068633%
 0.48

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 19454 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.12429474625733057%
 0.50

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 19454 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.127030420098401%
 0.51

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 93231 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 2 times.
0.12459210210962082%
 0.50

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 1836 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 8 times.
0.12976609393947144%
 0.52

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 136416 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.1250084003028272%
 0.50

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 136416 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.11977493730251855%
 0.48

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 136416 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.12149960124580209%
 0.49

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 136416 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.12685200658702683%
 0.51

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 6883 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.3776419324086359%
 1.51

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 6883 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.12405686157549835%
 0.50

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 110390 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 3 times.
0.1253652273255755%
 0.50

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 137835 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.12405686157549835%
 0.50

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 137334 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.3782961152836745%
 1.52

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 137334 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.1170392634614481%
 0.47

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 137835 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.150640474770248%
 0.60

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 137334 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.11121108875655893%
 0.45

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 137334 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.11133003109747502%
 0.45

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 138636 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.11216262748388776%
 0.45

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359)
  vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
  +
SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 138636 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem')))
  468 similar queries.   Duplicated 6 times.
0.10514502936983752%
 0.42

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py