Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Unit Assay Type Assay Description Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles
CHEMBL3730217 fpr2_human Human No 10.2 EC50 = 0.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
500 8 2 3 4.1 C1CCN(CC1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3730217 fpr2_human Human No 10.2 EC50 = 0.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
500 8 2 3 4.1 C1CCN(CC1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728769 fpr2_human Human No 10.0 EC50 = 0.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
486 8 2 3 3.8 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728769 fpr2_human Human No 10.0 EC50 = 0.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
486 8 2 3 3.8 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3729012 fpr2_human Human No 9.9 EC50 = 0.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
472 5 3 3 3.1 C1CC(CCC1CN)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3730760 fpr2_human Human No 9.9 EC50 = 0.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
472 5 3 3 3.1 C1CC(CCC1CN)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3729012 fpr2_human Human No 9.9 EC50 = 0.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
472 5 3 3 3.1 C1CC(CCC1CN)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3730760 fpr2_human Human No 9.9 EC50 = 0.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
472 5 3 3 3.1 C1CC(CCC1CN)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3727613 fpr2_human Human No 9.8 EC50 = 0.2 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
446 8 3 3 2.7 C1CC12C3C=CC2C(C3C(=O)NCCCCCN)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3727613 fpr2_human Human No 9.8 EC50 = 0.2 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
446 8 3 3 2.7 C1CC12C3C=CC2C(C3C(=O)NCCCCCN)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3728932 fpr2_human Human No 9.7 EC50 = 0.2 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
444 4 3 3 2.7 C1CNCCC1NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728932 fpr2_human Human No 9.7 EC50 = 0.2 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
444 4 3 3 2.7 C1CNCCC1NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3729214 fpr2_human Human No 9.6 EC50 = 0.2 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
417 5 2 2 3.9 CC(C)CNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3729214 fpr2_human Human No 9.6 EC50 = 0.2 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
417 5 2 2 3.9 CC(C)CNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3730056 fpr2_human Human No 9.5 EC50 = 0.3 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
504 8 2 4 4.3 C1CC(N(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5)F
CHEMBL3730056 fpr2_human Human No 9.5 EC50 = 0.3 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
504 8 2 4 4.3 C1CC(N(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5)F
CHEMBL3730438 fpr2_human Human No 9.5 EC50 = 0.3 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
432 7 3 3 2.3 C1CC12C3C=CC2C(C3C(=O)NCCCCN)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3730438 fpr2_human Human No 9.5 EC50 = 0.3 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
432 7 3 3 2.3 C1CC12C3C=CC2C(C3C(=O)NCCCCN)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3730133 fpr2_human Human No 9.5 EC50 = 0.4 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
504 8 2 4 4.3 C1CC(N(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5)F
CHEMBL3731671 fpr2_human Human No 9.5 EC50 = 0.4 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
488 8 2 3 4.4 C1CCN(C1)CCCCNC(=O)C2C3CCC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3730133 fpr2_human Human No 9.5 EC50 = 0.4 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
504 8 2 4 4.3 C1CC(N(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5)F
CHEMBL3731671 fpr2_human Human No 9.5 EC50 = 0.4 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
488 8 2 3 4.4 C1CCN(C1)CCCCNC(=O)C2C3CCC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3729434 fpr2_human Human No 9.4 EC50 = 0.4 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
472 8 2 3 3.4 C1CN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3729434 fpr2_human Human No 9.4 EC50 = 0.4 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
472 8 2 3 3.4 C1CN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3732621 fpr2_human Human No 9.4 EC50 = 0.4 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
432 6 2 3 2.6 CN(C)CCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3732621 fpr2_human Human No 9.4 EC50 = 0.4 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
432 6 2 3 2.6 CN(C)CCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3731259 fpr2_human Human No 9.4 EC50 = 0.5 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
467 5 3 5 3.2 C1CC(CNC1)CNC(=O)C2C3CCC(C2C(=O)NC4=NC=C(S4)Br)C35CC5
CHEMBL3731107 fpr2_human Human No 9.4 EC50 = 0.5 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
455 8 3 5 3.0 C1CC2C(C(C1C23CC3)C(=O)NCCCCCN)C(=O)NC4=NC=C(S4)Br
CHEMBL3731259 fpr2_human Human No 9.4 EC50 = 0.5 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
467 5 3 5 3.2 C1CC(CNC1)CNC(=O)C2C3CCC(C2C(=O)NC4=NC=C(S4)Br)C35CC5
CHEMBL3731107 fpr2_human Human No 9.4 EC50 = 0.5 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
455 8 3 5 3.0 C1CC2C(C(C1C23CC3)C(=O)NCCCCCN)C(=O)NC4=NC=C(S4)Br
CHEMBL3730874 fpr2_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
434 6 3 3 2.0 C1CC2C(C(C1C23CC3)C(=O)NCCC(=O)N)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3730874 fpr2_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
434 6 3 3 2.0 C1CC2C(C(C1C23CC3)C(=O)NCCC(=O)N)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3727601 fpr2_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
441 7 3 5 2.6 C1CC2C(C(C1C23CC3)C(=O)NCCCCN)C(=O)NC4=NC=C(S4)Br
CHEMBL3727601 fpr2_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
441 7 3 5 2.6 C1CC2C(C(C1C23CC3)C(=O)NCCCCN)C(=O)NC4=NC=C(S4)Br
CHEMBL3728644 fpr2_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
502 8 2 4 2.9 C1CC12C3C=CC2C(C3C(=O)NCCCCN4CCOCC4)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3728644 fpr2_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
502 8 2 4 2.9 C1CC12C3C=CC2C(C3C(=O)NCCCCN4CCOCC4)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3731166 fpr2_human Human No 9.3 EC50 = 0.6 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
480 6 3 3 2.9 C1CC12C3C=CC2C(C3C(=O)NCC4=CC=CC(=C4)CN)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3731166 fpr2_human Human No 9.3 EC50 = 0.6 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
480 6 3 3 2.9 C1CC12C3C=CC2C(C3C(=O)NCC4=CC=CC(=C4)CN)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3728245 fpr2_human Human No 9.2 EC50 = 0.6 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
453 8 3 5 2.4 C1CC12C3C=CC2C(C3C(=O)NCCCCCN)C(=O)NC4=NC=C(S4)Br
CHEMBL3729460 fpr2_human Human No 9.2 EC50 = 0.7 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
500 9 2 3 4.1 C1CCN(C1)CCCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3729460 fpr2_human Human No 9.2 EC50 = 0.7 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
500 9 2 3 4.1 C1CCN(C1)CCCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3732081 fpr2_human Human No 9.2 EC50 = 0.7 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
476 9 2 3 4.3 CN(C)CCCCCNC(=O)C1C2CCC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3732081 fpr2_human Human No 9.2 EC50 = 0.7 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
476 9 2 3 4.3 CN(C)CCCCCNC(=O)C1C2CCC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3730159 fpr2_human Human No 9.1 EC50 = 0.7 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
502 9 2 4 2.9 C1CCN(C1)CCOCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3730159 fpr2_human Human No 9.1 EC50 = 0.7 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
502 9 2 4 2.9 C1CCN(C1)CCOCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3731113 fpr2_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
458 5 3 3 2.8 C1CNCCC1CNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3731113 fpr2_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
458 5 3 3 2.8 C1CNCCC1CNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3732902 fpr2_human Human No 9.1 EC50 = 0.9 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
504 8 2 4 3.9 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC(=C(C=C4)Br)F)C35CC5
CHEMBL3732902 fpr2_human Human No 9.1 EC50 = 0.9 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
504 8 2 4 3.9 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC(=C(C=C4)Br)F)C35CC5
CHEMBL3731635 fpr2_human Human No 9.1 EC50 = 0.9 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
530 8 2 4 3.4 CN1CCCN(CC1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3731635 fpr2_human Human No 9.1 EC50 = 0.9 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
530 8 2 4 3.4 CN1CCCN(CC1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3729013 fpr2_human Human No 9.0 EC50 = 0.9 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
430 4 3 3 2.3 C1CNCC1NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3729013 fpr2_human Human No 9.0 EC50 = 0.9 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
430 4 3 3 2.3 C1CNCC1NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3729228 fpr2_human Human No 9.0 EC50 = 1.0 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
446 6 3 3 2.8 CC(C)(CN)CNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3729228 fpr2_human Human No 9.0 EC50 = 1.0 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
446 6 3 3 2.8 CC(C)(CN)CNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3731461 fpr2_human Human No 9.0 EC50 = 1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
419 6 3 3 2.2 C1CC12C3C=CC2C(C3C(=O)NCCCO)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3729246 fpr2_human Human No 9.0 EC50 = 1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
488 10 2 3 4.0 CCN(CC)CCCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3731461 fpr2_human Human No 9.0 EC50 = 1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
419 6 3 3 2.2 C1CC12C3C=CC2C(C3C(=O)NCCCO)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3729246 fpr2_human Human No 9.0 EC50 = 1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
488 10 2 3 4.0 CCN(CC)CCCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL2408793 fpr2_human Human No 9.0 EC50 = 1 Funct
Modulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assayModulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assay
414 7 4 4 2.9 CC(C)CC(C(=O)NC(C)(C)C(=O)O)NC(=O)NC1=CC=C(C=C1)Br
CHEMBL3731163 fpr2_human Human No 9.0 EC50 = 1.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
487 8 2 4 3.0 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CN=C(C=C4)Br)C35CC5
CHEMBL3731849 fpr2_human Human No 9.0 EC50 = 1.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
432 6 3 3 1.4 C1CC12C3C=CC2C(C3C(=O)NCCC(=O)N)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3731163 fpr2_human Human No 9.0 EC50 = 1.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
487 8 2 4 3.0 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CN=C(C=C4)Br)C35CC5
CHEMBL3731849 fpr2_human Human No 9.0 EC50 = 1.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
432 6 3 3 1.4 C1CC12C3C=CC2C(C3C(=O)NCCC(=O)N)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3730197 fpr2_human Human No 8.9 EC50 = 1.2 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
530 6 2 4 3.6 CC(C)(C)OC(=O)N1CCC(C1)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3730197 fpr2_human Human No 8.9 EC50 = 1.2 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
530 6 2 4 3.6 CC(C)(C)OC(=O)N1CCC(C1)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3729500 fpr2_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
429 4 2 2 3.8 C1CCC(C1)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728245 fpr2_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
453 8 3 5 2.4 C1CC12C3C=CC2C(C3C(=O)NCCCCCN)C(=O)NC4=NC=C(S4)Br
CHEMBL3730330 fpr2_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
503 9 2 4 3.6 C1CCN(C1)CCCCNC(=O)C2C3CCC(C2C(=O)NCC4=CN=C(C=C4)Br)C35CC5
CHEMBL3731889 fpr2_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
504 8 2 4 3.9 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=C(C=C(C=C4)Br)F)C35CC5
CHEMBL3732566 fpr2_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
503 7 2 4 3.4 CN1CCN(CC1)CCCNC(=O)C2C3CCC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3729500 fpr2_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
429 4 2 2 3.8 C1CCC(C1)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728245 fpr2_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
453 8 3 5 2.4 C1CC12C3C=CC2C(C3C(=O)NCCCCCN)C(=O)NC4=NC=C(S4)Br
CHEMBL3730330 fpr2_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
503 9 2 4 3.6 C1CCN(C1)CCCCNC(=O)C2C3CCC(C2C(=O)NCC4=CN=C(C=C4)Br)C35CC5
CHEMBL3731889 fpr2_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
504 8 2 4 3.9 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=C(C=C(C=C4)Br)F)C35CC5
CHEMBL3732566 fpr2_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
503 7 2 4 3.4 CN1CCN(CC1)CCCNC(=O)C2C3CCC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3732404 fpr2_human Human No 8.9 EC50 = 1.4 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
418 6 3 3 1.9 C1CC12C3C=CC2C(C3C(=O)NCCCN)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3731163 fpr2_human Human No 8.9 EC50 = 1.4 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
487 8 2 4 3.0 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CN=C(C=C4)Br)C35CC5
CHEMBL3732404 fpr2_human Human No 8.9 EC50 = 1.4 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
418 6 3 3 1.9 C1CC12C3C=CC2C(C3C(=O)NCCCN)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3729487 fpr2_human Human No 8.8 EC50 = 1.5 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
447 5 2 3 3.6 C1CC(OC1)CNC(=O)C2C3CCC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3729487 fpr2_human Human No 8.8 EC50 = 1.5 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
447 5 2 3 3.6 C1CC(OC1)CNC(=O)C2C3CCC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3727408 fpr2_human Human No 8.8 EC50 = 1.6 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
443 8 2 4 3.0 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CN=C(C=C4)Cl)C35CC5
CHEMBL3727408 fpr2_human Human No 8.8 EC50 = 1.6 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
443 8 2 4 3.0 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CN=C(C=C4)Cl)C35CC5
CHEMBL3733012 fpr2_human Human No 8.7 EC50 = 1.8 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
447 8 2 3 3.1 CCOCCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3728559 fpr2_human Human No 8.7 EC50 = 1.8 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
421 6 3 3 2.8 C1CC2C(C(C1C23CC3)C(=O)NCCCO)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3733012 fpr2_human Human No 8.8 EC50 = 1.8 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
447 8 2 3 3.1 CCOCCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3728559 fpr2_human Human No 8.8 EC50 = 1.8 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
421 6 3 3 2.8 C1CC2C(C(C1C23CC3)C(=O)NCCCO)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3729988 fpr2_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
404 5 3 3 1.6 C1CC12C3C=CC2C(C3C(=O)NCCN)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3728025 fpr2_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
465 8 2 5 3.5 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC5=C(C=C4)SC=N5)C36CC6
CHEMBL3729988 fpr2_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
404 5 3 3 1.6 C1CC12C3C=CC2C(C3C(=O)NCCN)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3728025 fpr2_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
465 8 2 5 3.5 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC5=C(C=C4)SC=N5)C36CC6
CHEMBL211885 fpr2_human Human Yes 7.0 EC50 = 100 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
390 3 2 6 2.3 CC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL378064 fpr2_human Human No 7.0 EC50 = 100 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
396 5 2 4 4.4 CCN1C(=C(C(=O)N1C2=CC=CC=C2)NC(=O)NC3=CC(=C(C=C3)C)F)C(C)C
CHEMBL1289381 fpr2_human Human Yes 7.0 EC50 = 100 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
349 5 2 2 3.5 COC1=CC=C(C=C1)CCNC(=O)NC2=CC=C(C=C2)Br
CHEMBL3728007 fpr2_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
486 5 3 3 3.4 C1CCC(C(C1)C(=O)N)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL211885 fpr2_human Human Yes 7.0 EC50 = 100 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
390 3 2 6 2.3 CC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL378064 fpr2_human Human No 7.0 EC50 = 100 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
396 5 2 4 4.4 CCN1C(=C(C(=O)N1C2=CC=CC=C2)NC(=O)NC3=CC(=C(C=C3)C)F)C(C)C
CHEMBL1289381 fpr2_human Human Yes 7.0 EC50 = 100 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
349 5 2 2 3.5 COC1=CC=C(C=C1)CCNC(=O)NC2=CC=C(C=C2)Br
CHEMBL3728007 fpr2_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
486 5 3 3 3.4 C1CCC(C(C1)C(=O)N)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL2391446 fpr2_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
456 6 1 5 2.9 CC1=NN(C(=O)C(=C1)C(=O)C2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL3590074 fprs1_mouse Mouse No 6.0 EC50 = 1000 Funct
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
526 9 4 4 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=CC=N5
CHEMBL3590214 fpr2_human Human Yes 5.0 EC50 = 10000 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
348 5 2 4 3.8 COC1=CC2=C(C=C1)N=C(N2)SCC(=O)NC3=CC=CC=C3Cl
CHEMBL3732039 fpr2_human Human No 5.0 EC50 = 10000 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
508 9 2 7 4.0 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC(=C(C=C4)F)C(F)(F)F)C35CC5
CHEMBL3730690 fpr2_human Human No 5.0 EC50 = 10000 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
499 8 2 5 4.5 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=NC5=C(S4)C=C(C=C5)Cl)C36CC6
CHEMBL3590214 fpr2_human Human Yes 5.0 EC50 = 10000 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
348 5 2 4 3.8 COC1=CC2=C(C=C1)N=C(N2)SCC(=O)NC3=CC=CC=C3Cl
CHEMBL3732039 fpr2_human Human No 5.0 EC50 = 10000 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
508 9 2 7 4.0 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC(=C(C=C4)F)C(F)(F)F)C35CC5
CHEMBL3730690 fpr2_human Human No 5.0 EC50 = 10000 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
499 8 2 5 4.5 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=NC5=C(S4)C=C(C=C5)Cl)C36CC6
CHEMBL404003 fpr2_human Human Yes 6.0 EC50 = 1020 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
388 3 1 3 3.9 CC1=NC2=CC=CC=C2N1C3CCN(CC3)C(=O)C4=CC5=C(N4)C=CC(=C5)OC
CHEMBL404003 fpr2_human Human Yes 6.0 EC50 = 1020 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
388 3 1 3 3.9 CC1=NC2=CC=CC=C2N1C3CCN(CC3)C(=O)C4=CC5=C(N4)C=CC(=C5)OC
CHEMBL3733207 fpr2_human Human No 7.0 EC50 = 103 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
522 8 2 5 4.0 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC(=C(C=C4F)Br)F)C35CC5
CHEMBL3733047 fpr2_human Human No 7.0 EC50 = 103 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
431 7 2 2 4.2 CCCCC(=O)NCC1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3733207 fpr2_human Human No 7.0 EC50 = 103 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
522 8 2 5 4.0 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC(=C(C=C4F)Br)F)C35CC5
CHEMBL3733047 fpr2_human Human No 7.0 EC50 = 103 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
431 7 2 2 4.2 CCCCC(=O)NCC1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3728812 fpr2_human Human No 6.0 EC50 = 1040 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
403 8 3 6 0.4 CC(=O)C1=CSC(=N1)CNC(=O)C2C3C=CC(C2C(=O)NCCNC)C34CC4
CHEMBL3728812 fpr2_human Human No 6.0 EC50 = 1040 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
403 8 3 6 0.4 CC(=O)C1=CSC(=N1)CNC(=O)C2C3C=CC(C2C(=O)NCCNC)C34CC4
CHEMBL3731064 fpr2_human Human No 5.0 EC50 = 10400 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
498 9 2 3 5.1 CC(C)CCN1CCC(CC1)NC(=O)C2C3C=CC(C2C(=O)NCCC4=CC=C(C=C4)Cl)C35CC5
CHEMBL3731064 fpr2_human Human No 5.0 EC50 = 10400 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
498 9 2 3 5.1 CC(C)CCN1CCC(CC1)NC(=O)C2C3C=CC(C2C(=O)NCCC4=CC=C(C=C4)Cl)C35CC5
CHEMBL3733092 fpr2_human Human No 7.0 EC50 = 106 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
504 9 3 6 2.8 CC(=O)C1=CSC(=N1)CNC(=O)C2C3C=CC(C2C(=O)NCCCC4=NC5=CC=CC=C5N4)C36CC6
CHEMBL3733092 fpr2_human Human No 7.0 EC50 = 106 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
504 9 3 6 2.8 CC(=O)C1=CSC(=N1)CNC(=O)C2C3C=CC(C2C(=O)NCCCC4=NC5=CC=CC=C5N4)C36CC6
CHEMBL3728722 fpr2_human Human No 5.0 EC50 = 10600 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
491 9 2 4 3.9 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC(=NC(=C4)Cl)Cl)C35CC5
CHEMBL3728722 fpr2_human Human No 5.0 EC50 = 10600 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
491 9 2 4 3.9 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC(=NC(=C4)Cl)Cl)C35CC5
CHEMBL539401 fpr2_human Human No 5.0 EC50 = 10900 Funct
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
377 6 1 4 3.0 CC1=CC=C(C=C1)NC(=O)CN2C(=O)C(=CC(=N2)C)CC3=CC(=CC=C3)OC
CHEMBL539401 fpr2_human Human No 5.0 EC50 = 10900 Funct
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
377 6 1 4 3.0 CC1=CC=C(C=C1)NC(=O)CN2C(=O)C(=CC(=N2)C)CC3=CC(=CC=C3)OC
CHEMBL3729977 fpr2_human Human No 8.0 EC50 = 11 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
458 8 3 6 2.0 C1CC2C(C(C1C23CC3)C(=O)NCCOCCO)C(=O)NC4=NC=C(S4)Br
CHEMBL3731311 fpr2_human Human No 8.0 EC50 = 11 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
532 10 3 4 3.9 CC(C)(C)OC(=O)NCCCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3730777 fpr2_human Human No 8.0 EC50 = 11 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
446 6 1 3 2.7 CN(C)CCN(C)C(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3729977 fpr2_human Human No 8.0 EC50 = 11 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
458 8 3 6 2.0 C1CC2C(C(C1C23CC3)C(=O)NCCOCCO)C(=O)NC4=NC=C(S4)Br
CHEMBL3731311 fpr2_human Human No 8.0 EC50 = 11 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
532 10 3 4 3.9 CC(C)(C)OC(=O)NCCCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3730777 fpr2_human Human No 8.0 EC50 = 11 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
446 6 1 3 2.7 CN(C)CCN(C)C(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3590075 fpr2_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
543 9 4 4 6.3 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=C(C=C5)F
CHEMBL562910 fpr2_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
393 7 1 5 2.6 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)OC
CHEMBL562910 fpr2_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
393 7 1 5 2.6 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)OC
CHEMBL3590075 fpr2_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
543 9 4 4 6.3 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=C(C=C5)F
CHEMBL562910 fpr2_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
393 7 1 5 2.6 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)OC
CHEMBL562910 fpr2_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
393 7 1 5 2.6 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)OC
CHEMBL3728279 fpr2_human Human No 5.0 EC50 = 11100 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
450 9 2 3 3.7 CC1=CC(=C(C=C1)C)CNC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3728279 fpr2_human Human No 5.0 EC50 = 11100 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
450 9 2 3 3.7 CC1=CC(=C(C=C1)C)CNC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3730474 fpr2_human Human No 7.0 EC50 = 112 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
517 6 2 3 4.8 C1CC12C3C=CC2C(C3CNC(=O)C4=CC=NN4C5=CC=CC=C5)C(=O)NC6=CC=C(C=C6)Br
CHEMBL3730474 fpr2_human Human No 7.0 EC50 = 112 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
517 6 2 3 4.8 C1CC12C3C=CC2C(C3CNC(=O)C4=CC=NN4C5=CC=CC=C5)C(=O)NC6=CC=C(C=C6)Br
CHEMBL3732166 fpr2_human Human No 7.0 EC50 = 113 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
448 7 3 3 1.9 C1CC2C(C(C1C23CC3)C(=O)NCCC(=O)N)C(=O)NCC4=CC=C(C=C4)Br
CHEMBL3732166 fpr2_human Human No 7.0 EC50 = 113 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
448 7 3 3 1.9 C1CC2C(C(C1C23CC3)C(=O)NCCC(=O)N)C(=O)NCC4=CC=C(C=C4)Br
CHEMBL3731489 fpr2_human Human No 6.9 EC50 = 114 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
446 7 3 3 1.6 C1CC12C3C=CC2C(C3CNC(=O)CCC(=O)N)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3731489 fpr2_human Human No 6.9 EC50 = 114 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
446 7 3 3 1.6 C1CC12C3C=CC2C(C3CNC(=O)CCC(=O)N)C(=O)NC4=CC=C(C=C4)Br
CHEMBL2391437 fpr2_human Human No 4.9 EC50 = 11400 Funct
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
418 5 1 4 3.0 CC1=NN(C(=O)C(=C1)CC2=CC=CS2)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL3731544 fpr2_human Human No 6.9 EC50 = 115 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
469 5 2 3 3.5 CC1=CC(=NN1C)C(=O)NCC2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3731544 fpr2_human Human No 6.9 EC50 = 115 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
469 5 2 3 3.5 CC1=CC(=NN1C)C(=O)NCC2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL2391277 fpr2_human Human No 4.9 EC50 = 11600 Funct
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
412 5 1 3 3.3 CC1=NN(C(=O)C(=C1)CC2=CC=CC=C2)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL3728830 fpr2_human Human No 6.9 EC50 = 117 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
518 9 2 4 3.8 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC(=C(C=C4)Br)F)C35CC5
CHEMBL3728830 fpr2_human Human No 6.9 EC50 = 117 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
518 9 2 4 3.8 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC(=C(C=C4)Br)F)C35CC5
CHEMBL3729615 fpr2_human Human No 6.9 EC50 = 118 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
500 5 2 3 3.3 CC(C(=O)N1CCCCC1)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3732516 fpr2_human Human No 6.9 EC50 = 118 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
466 5 2 3 3.8 CC1=C(C=NC=C1)C(=O)NCC2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3729615 fpr2_human Human No 6.9 EC50 = 118 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
500 5 2 3 3.3 CC(C(=O)N1CCCCC1)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3732516 fpr2_human Human No 6.9 EC50 = 118 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
466 5 2 3 3.8 CC1=C(C=NC=C1)C(=O)NCC2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL551590 fpr2_human Human No 4.9 EC50 = 11800 Funct
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
456 7 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CCC(=O)NC3=CC=C(C=C3)Br
CHEMBL551590 fpr2_human Human No 4.9 EC50 = 11800 Funct
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
456 7 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CCC(=O)NC3=CC=C(C=C3)Br
CHEMBL551590 fpr2_human Human No 4.9 EC50 = 11800 Funct
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
456 7 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CCC(=O)NC3=CC=C(C=C3)Br
CHEMBL551590 fpr2_human Human No 4.9 EC50 = 11800 Funct
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
456 7 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CCC(=O)NC3=CC=C(C=C3)Br
CHEMBL3731316 fpr2_human Human No 5.9 EC50 = 1190 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
550 10 2 5 4.4 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCCC4=CC(=C(C(=C4)F)Br)F)C35CC5
CHEMBL3731316 fpr2_human Human No 5.9 EC50 = 1190 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
550 10 2 5 4.4 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCCC4=CC(=C(C(=C4)F)Br)F)C35CC5
CHEMBL3731600 fpr2_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
458 6 2 3 3.1 C1CCN(C1)CCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3730902 fpr2_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
518 8 2 4 3.4 CC(C)(C)OC(=O)N(C)CCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3732504 fpr2_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
456 6 2 4 2.2 C1CC12C3C=CC2C(C3C(=O)NCCN4C=NC=N4)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3729617 fpr2_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
453 6 3 5 2.5 CC(C)(CN)CNC(=O)C1C2C=CC(C1C(=O)NC3=NC=C(S3)Br)C24CC4
CHEMBL3731600 fpr2_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
458 6 2 3 3.1 C1CCN(C1)CCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3730902 fpr2_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
518 8 2 4 3.4 CC(C)(C)OC(=O)N(C)CCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3732504 fpr2_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
456 6 2 4 2.2 C1CC12C3C=CC2C(C3C(=O)NCCN4C=NC=N4)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3729617 fpr2_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
453 6 3 5 2.5 CC(C)(CN)CNC(=O)C1C2C=CC(C1C(=O)NC3=NC=C(S3)Br)C24CC4
CHEMBL3727914 fpr2_human Human No 6.9 EC50 = 120 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
460 8 2 7 2.6 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=NC=C(S4)[N+](=O)[O-])C35CC5
CHEMBL3727914 fpr2_human Human No 6.9 EC50 = 120 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
460 8 2 7 2.6 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=NC=C(S4)[N+](=O)[O-])C35CC5
CHEMBL554291 fpr2_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
423 8 1 6 2.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC(=C(C=C3)OC)OC
CHEMBL554291 fpr2_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
423 8 1 6 2.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC(=C(C=C3)OC)OC
CHEMBL554291 fpr2_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
423 8 1 6 2.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC(=C(C=C3)OC)OC
CHEMBL554291 fpr2_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
423 8 1 6 2.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC(=C(C=C3)OC)OC
CHEMBL3729966 fpr2_human Human No 6.9 EC50 = 121 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
449 8 2 5 3.4 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=NC=C(S4)Cl)C35CC5
CHEMBL3732195 fpr2_human Human No 6.9 EC50 = 121 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
502 11 2 3 3.9 CCN(CC)CCCCNC(=O)C1C2C=CC(C1C(=O)NCC3=CC=C(C=C3)Br)C24CC4
CHEMBL3729966 fpr2_human Human No 6.9 EC50 = 121 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
449 8 2 5 3.4 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=NC=C(S4)Cl)C35CC5
CHEMBL3732195 fpr2_human Human No 6.9 EC50 = 121 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
502 11 2 3 3.9 CCN(CC)CCCCNC(=O)C1C2C=CC(C1C(=O)NCC3=CC=C(C=C3)Br)C24CC4
CHEMBL430016 fpr2_human Human No 4.9 EC50 = 12200 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
442 4 1 6 5.2 CCC1=NC2=CC=CC=C2N1C3CCN(C3)C(=O)C4=CC5=C(N4)C=CC(=C5)OC(F)(F)F
CHEMBL430016 fpr2_human Human No 4.9 EC50 = 12200 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
442 4 1 6 5.2 CCC1=NC2=CC=CC=C2N1C3CCN(C3)C(=O)C4=CC5=C(N4)C=CC(=C5)OC(F)(F)F
CHEMBL3730675 fpr2_human Human No 6.9 EC50 = 123 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
534 6 2 3 4.6 C1CN(CCC1NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5)CC6=CC=CC=C6
CHEMBL3730675 fpr2_human Human No 6.9 EC50 = 123 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
534 6 2 3 4.6 C1CN(CCC1NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5)CC6=CC=CC=C6
CHEMBL380160 fpr2_human Human Yes 4.9 EC50 = 12300 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
364 4 2 3 2.5 CC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)C(C)C
CHEMBL562456 fpr2_human Human No 4.9 EC50 = 12300 Funct
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
408 6 1 6 2.4 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)[N+](=O)[O-]
CHEMBL380160 fpr2_human Human Yes 4.9 EC50 = 12300 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
364 4 2 3 2.5 CC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)C(C)C
CHEMBL562456 fpr2_human Human No 4.9 EC50 = 12300 Funct
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
408 6 1 6 2.4 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)[N+](=O)[O-]
CHEMBL3729198 fpr2_human Human No 6.9 EC50 = 125 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
417 5 2 2 3.9 CC(C)C(=O)NCC1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3729198 fpr2_human Human No 6.9 EC50 = 125 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
417 5 2 2 3.9 CC(C)C(=O)NCC1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL450023 fpr2_human Human Yes 5.9 EC50 = 1260 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
336 3 2 3 1.7 CC1=CC=C(C=C1)NC(=O)NC2=C(N(N(C2=O)C3=CC=CC=C3)C)C
CHEMBL450023 fpr2_human Human Yes 5.9 EC50 = 1260 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
336 3 2 3 1.7 CC1=CC=C(C=C1)NC(=O)NC2=C(N(N(C2=O)C3=CC=CC=C3)C)C
CHEMBL3589947 fpr2_human Human No 4.9 EC50 = 12600 Funct
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid
544 9 4 5 5.6 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC(=NC=C5)F
CHEMBL3589947 fpr2_human Human No 4.9 EC50 = 12600 Funct
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid
544 9 4 5 5.6 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC(=NC=C5)F
CHEMBL3732017 fpr2_human Human No 6.9 EC50 = 129 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
482 5 3 5 3.8 C1CCC(CC1)(CNC(=O)C2C3CCC(C2C(=O)NC4=NC=C(S4)Br)C35CC5)O
CHEMBL3732017 fpr2_human Human No 6.9 EC50 = 129 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
482 5 3 5 3.8 C1CCC(CC1)(CNC(=O)C2C3CCC(C2C(=O)NC4=NC=C(S4)Br)C35CC5)O
CHEMBL3727417 fpr2_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
497 7 2 3 3.5 CC1=CC(=NN1CCC(=O)NCC2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5)C
CHEMBL3729082 fpr2_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
518 9 2 4 3.8 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=C(C=C(C=C4)Br)F)C35CC5
CHEMBL3727544 fpr2_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
441 5 2 3 3.1 C1CC12C3C=CC2C(C3C(=O)NCC4=COC=C4)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3729012 fpr2_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
472 5 3 3 3.1 C1CC(CCC1CN)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3730760 fpr2_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
472 5 3 3 3.1 C1CC(CCC1CN)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3733217 fpr2_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
427 6 3 5 2.4 CNCCNC(=O)C1C2CCC(C1C(=O)NC3=NC=C(S3)Br)C24CC4
CHEMBL3730919 fpr2_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
520 9 2 4 4.4 C1CCN(C1)CCCCNC(=O)C2C3CCC(C2C(=O)NCC4=C(C=C(C=C4)Br)F)C35CC5
CHEMBL3727417 fpr2_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
497 7 2 3 3.5 CC1=CC(=NN1CCC(=O)NCC2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5)C
CHEMBL3729082 fpr2_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
518 9 2 4 3.8 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=C(C=C(C=C4)Br)F)C35CC5
CHEMBL3727544 fpr2_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
441 5 2 3 3.1 C1CC12C3C=CC2C(C3C(=O)NCC4=COC=C4)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3733217 fpr2_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
427 6 3 5 2.4 CNCCNC(=O)C1C2CCC(C1C(=O)NC3=NC=C(S3)Br)C24CC4
CHEMBL3730919 fpr2_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
520 9 2 4 4.4 C1CCN(C1)CCCCNC(=O)C2C3CCC(C2C(=O)NCC4=C(C=C(C=C4)Br)F)C35CC5
CHEMBL3588923 fpr2_human Human No 6.9 EC50 = 130 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
541 8 3 4 3.8 CCOC(=O)C1CCN(CC1)C(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)NC4=CC=C(C=C4)Br
CHEMBL248928 fpr2_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
388 4 1 3 4.0 CCC1=NC2=CC=CC=C2N1C3CCN(C3)C(=O)C4=CC5=C(N4)C=CC(=C5)OC
CHEMBL3588923 fpr2_human Human No 6.9 EC50 = 130 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
541 8 3 4 3.8 CCOC(=O)C1CCN(CC1)C(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)NC4=CC=C(C=C4)Br
CHEMBL248928 fpr2_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
388 4 1 3 4.0 CCC1=NC2=CC=CC=C2N1C3CCN(C3)C(=O)C4=CC5=C(N4)C=CC(=C5)OC
CHEMBL3728768 fpr2_human Human No 6.9 EC50 = 131 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
486 6 2 3 3.7 CCN1CCC(CC1)C(=O)NCC2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728768 fpr2_human Human No 6.9 EC50 = 131 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
486 6 2 3 3.7 CCN1CCC(CC1)C(=O)NCC2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL562380 fpr2_human Human No 4.9 EC50 = 13100 Funct
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC=C(C=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL562380 fpr2_human Human No 4.9 EC50 = 13100 Funct
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC=C(C=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL562380 fpr2_human Human No 4.9 EC50 = 13100 Funct
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC=C(C=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL562380 fpr2_human Human No 4.9 EC50 = 13100 Funct
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC=C(C=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL3729626 fpr2_human Human No 6.9 EC50 = 133 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
459 8 1 2 5.0 CCCCCCN(C)C(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3729626 fpr2_human Human No 6.9 EC50 = 133 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
459 8 1 2 5.0 CCCCCCN(C)C(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3729699 fpr2_human Human No 5.9 EC50 = 1330 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
444 8 2 5 2.3 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CN=C(N=C4)Cl)C35CC5
CHEMBL3729699 fpr2_human Human No 5.9 EC50 = 1330 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
444 8 2 5 2.3 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CN=C(N=C4)Cl)C35CC5
CHEMBL3732149 fpr2_human Human No 6.9 EC50 = 136 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
480 7 2 3 3.6 C1CC12C3C=CC2C(C3CNC(=O)CCC4=CN=CC=C4)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3732149 fpr2_human Human No 6.9 EC50 = 136 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
480 7 2 3 3.6 C1CC12C3C=CC2C(C3CNC(=O)CCC4=CN=CC=C4)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3731053 fpr2_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
441 7 3 5 2.8 CNCCCNC(=O)C1C2CCC(C1C(=O)NC3=NC=C(S3)Br)C24CC4
CHEMBL3731053 fpr2_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
441 7 3 5 2.8 CNCCCNC(=O)C1C2CCC(C1C(=O)NC3=NC=C(S3)Br)C24CC4
CHEMBL209995 fpr2_human Human No 6.9 EC50 = 140 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
371 4 2 3 3.8 CCC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Cl
CHEMBL3588925 fpr2_human Human No 6.9 EC50 = 140 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
416 5 2 2 3.6 C1CCN(C1)C(=O)C(CC2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Br
CHEMBL3588922 fpr2_human Human No 6.9 EC50 = 140 Funct
Agonist activity at FPR2 (unknown origin) by Fluo4 florescence based intracellular Ca2+ mobilization assayAgonist activity at FPR2 (unknown origin) by Fluo4 florescence based intracellular Ca2+ mobilization assay
722 13 2 6 7.6 CCCC1CNC(=O)C(=O)N1CC2CCCN2CC(CC3=CC4=CC=CC=C4C=C3)N5CC(N(C(=O)C5=O)CC6CCCCC6)CC7=CC=C(C=C7)O
CHEMBL3729817 fpr2_human Human No 6.9 EC50 = 140 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
457 9 2 6 1.7 CC(=O)C1=CSC(=N1)CNC(=O)C2C3C=CC(C2C(=O)NCCCN4CCCC4)C35CC5
CHEMBL3731264 fpr2_human Human No 6.9 EC50 = 140 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
471 10 2 6 2.1 CC(=O)C1=CSC(=N1)CNC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL209995 fpr2_human Human No 6.9 EC50 = 140 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
371 4 2 3 3.8 CCC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Cl
CHEMBL3588925 fpr2_human Human No 6.9 EC50 = 140 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
416 5 2 2 3.6 C1CCN(C1)C(=O)C(CC2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Br
CHEMBL3588922 fpr2_human Human No 6.9 EC50 = 140 Funct
Agonist activity at FPR2 (unknown origin) by Fluo4 florescence based intracellular Ca2+ mobilization assayAgonist activity at FPR2 (unknown origin) by Fluo4 florescence based intracellular Ca2+ mobilization assay
722 13 2 6 7.6 CCCC1CNC(=O)C(=O)N1CC2CCCN2CC(CC3=CC4=CC=CC=C4C=C3)N5CC(N(C(=O)C5=O)CC6CCCCC6)CC7=CC=C(C=C7)O
CHEMBL3729817 fpr2_human Human No 6.9 EC50 = 140 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
457 9 2 6 1.7 CC(=O)C1=CSC(=N1)CNC(=O)C2C3C=CC(C2C(=O)NCCCN4CCCC4)C35CC5
CHEMBL3731264 fpr2_human Human No 6.9 EC50 = 140 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
471 10 2 6 2.1 CC(=O)C1=CSC(=N1)CNC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL249339 fpr2_human Human No 4.9 EC50 = 14100 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
393 3 1 2 4.6 CCC1=NC2=CC=CC=C2N1C3CCN(C3)C(=O)C4=CC5=C(N4)C=CC(=C5)Cl
CHEMBL2391286 fpr2_human Human No 4.9 EC50 = 14100 Funct
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
418 5 1 4 3.0 CC1=NN(C(=O)C(=C1)CC2=CSC=C2)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL249339 fpr2_human Human No 4.9 EC50 = 14100 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
393 3 1 2 4.6 CCC1=NC2=CC=CC=C2N1C3CCN(C3)C(=O)C4=CC5=C(N4)C=CC(=C5)Cl
CHEMBL562910 fpr2_human Human No 4.8 EC50 = 14400 Funct
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
393 7 1 5 2.6 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)OC
CHEMBL562910 fpr2_human Human No 4.8 EC50 = 14400 Funct
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
393 7 1 5 2.6 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)OC
CHEMBL3732159 fpr2_human Human No 6.8 EC50 = 146 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
464 7 3 4 1.4 C1CC12C3C=CC2C(C3C(=O)NCCC(=O)N)C(=O)NCC4=C(C=C(C=C4)Br)F
CHEMBL3729866 fpr2_human Human No 6.8 EC50 = 146 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
445 6 2 2 4.6 CC(C)(C)CCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3732159 fpr2_human Human No 6.8 EC50 = 146 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
464 7 3 4 1.4 C1CC12C3C=CC2C(C3C(=O)NCCC(=O)N)C(=O)NCC4=C(C=C(C=C4)Br)F
CHEMBL3729866 fpr2_human Human No 6.8 EC50 = 146 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
445 6 2 2 4.6 CC(C)(C)CCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3729343 fpr2_human Human No 6.8 EC50 = 147 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
458 4 2 3 3.1 CN1CCC(CC1)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3729343 fpr2_human Human No 6.8 EC50 = 147 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
458 4 2 3 3.1 CN1CCC(CC1)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL210475 fpr2_human Human No 5.8 EC50 = 1470 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
427 4 2 8 3.3 CC(C)C1=C(C(=O)N(N1C)C2=NCCS2)NC(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL210475 fpr2_human Human No 5.8 EC50 = 1470 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
427 4 2 8 3.3 CC(C)C1=C(C(=O)N(N1C)C2=NCCS2)NC(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL3590216 fpr2_human Human No 5.8 EC50 = 1480 Funct
Agonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assayAgonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assay
416 7 2 4 5.9 CCCCOC1=CC=C(C=C1)C(=O)NN2CC3=CC=CC=C3NC2C4=CC=C(C=C4)C
CHEMBL3590216 fpr2_human Human No 5.8 EC50 = 1480 Funct
Agonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assayAgonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assay
416 7 2 4 5.9 CCCCOC1=CC=C(C=C1)C(=O)NN2CC3=CC=CC=C3NC2C4=CC=C(C=C4)C
CHEMBL249338 fpr2_human Human No 5.8 EC50 = 1490 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
376 3 1 3 4.1 CCC1=NC2=CC=CC=C2N1C3CCN(C3)C(=O)C4=CC5=C(N4)C=CC(=C5)F
CHEMBL249338 fpr2_human Human No 5.8 EC50 = 1490 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
376 3 1 3 4.1 CCC1=NC2=CC=CC=C2N1C3CCN(C3)C(=O)C4=CC5=C(N4)C=CC(=C5)F
CHEMBL3731133 fpr2_human Human No 7.8 EC50 = 15 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
441 6 3 5 1.7 C1CC2C(C(C1C23CC3)C(=O)NCCC(=O)N)C(=O)NC4=NC=C(S4)Br
CHEMBL3731133 fpr2_human Human No 7.8 EC50 = 15 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
441 6 3 5 1.7 C1CC2C(C(C1C23CC3)C(=O)NCCC(=O)N)C(=O)NC4=NC=C(S4)Br
CHEMBL211555 fpr2_human Human No 6.8 EC50 = 150 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
420 4 2 8 2.7 CC(C)C1=C(C(=O)N(N1C)C2=CN=CN=C2)NC(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL211555 fpr2_human Human No 6.8 EC50 = 150 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
420 4 2 8 2.7 CC(C)C1=C(C(=O)N(N1C)C2=CN=CN=C2)NC(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL251772 fpr2_human Human No 5.8 EC50 = 1520 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
442 3 1 6 4.4 COC1=CC2=C(C=C1)NC(=C2)C(=O)N3CCC(CC3)N4C5=CC=CC=C5N=C4C(F)(F)F
CHEMBL251772 fpr2_human Human No 5.8 EC50 = 1520 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
442 3 1 6 4.4 COC1=CC2=C(C=C1)NC(=C2)C(=O)N3CCC(CC3)N4C5=CC=CC=C5N=C4C(F)(F)F
CHEMBL3731379 fpr2_human Human No 6.8 EC50 = 153 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
455 10 2 6 1.5 CC(=O)C1=NC(=CO1)CNC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3731379 fpr2_human Human No 6.8 EC50 = 153 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
455 10 2 6 1.5 CC(=O)C1=NC(=CO1)CNC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3729697 fpr2_human Human No 5.8 EC50 = 1540 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
476 9 2 6 3.3 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=C(C=C(C=C4F)F)F)C35CC5
CHEMBL3729697 fpr2_human Human No 5.8 EC50 = 1540 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
476 9 2 6 3.3 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=C(C=C(C=C4F)F)F)C35CC5
CHEMBL3727591 fpr2_human Human No 6.8 EC50 = 155 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
447 7 1 3 2.8 CN(CC1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4)C(=O)CCOC
CHEMBL3727591 fpr2_human Human No 6.8 EC50 = 155 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
447 7 1 3 2.8 CN(CC1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4)C(=O)CCOC
CHEMBL3730289 fpr2_human Human No 5.8 EC50 = 1550 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
493 8 2 5 3.5 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=NC(=CS4)Br)C35CC5
CHEMBL3730289 fpr2_human Human No 5.8 EC50 = 1550 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
493 8 2 5 3.5 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=NC(=CS4)Br)C35CC5
CHEMBL3730081 fpr2_human Human No 6.8 EC50 = 156 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
488 7 2 4 2.5 C1CC12C3C=CC2C(C3C(=O)NCCCN4CCOCC4)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3730081 fpr2_human Human No 6.8 EC50 = 156 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
488 7 2 4 2.5 C1CC12C3C=CC2C(C3C(=O)NCCCN4CCOCC4)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3730683 fpr2_human Human No 6.8 EC50 = 158 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
414 5 3 5 2.2 C1CC2C(C(C1C23CC3)C(=O)NCCO)C(=O)NC4=NC=C(S4)Br
CHEMBL3728360 fpr2_human Human No 6.8 EC50 = 158 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
504 5 2 3 5.2 C1CC12C3C=CC2C(C3CNC(=O)C4=C(C(=CC=C4)F)Cl)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3730683 fpr2_human Human No 6.8 EC50 = 158 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
414 5 3 5 2.2 C1CC2C(C(C1C23CC3)C(=O)NCCO)C(=O)NC4=NC=C(S4)Br
CHEMBL3728360 fpr2_human Human No 6.8 EC50 = 158 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
504 5 2 3 5.2 C1CC12C3C=CC2C(C3CNC(=O)C4=C(C(=CC=C4)F)Cl)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3729242 fpr2_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
474 7 2 3 4.0 C1CCN(C1)CCCNC(=O)C2C3CCC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3732748 fpr2_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
433 7 2 3 2.7 COCCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3728012 fpr2_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
472 6 2 3 3.5 CCN1CCCC1CNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3729242 fpr2_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
474 7 2 3 4.0 C1CCN(C1)CCCNC(=O)C2C3CCC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3732748 fpr2_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
433 7 2 3 2.7 COCCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3728012 fpr2_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
472 6 2 3 3.5 CCN1CCCC1CNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3590207 fpr2_human Human No 6.8 EC50 = 160 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
502 8 2 4 3.9 CCOC(=O)C1CCN(CC1)C(=O)C(CC2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Br
CHEMBL3728805 fpr2_human Human No 6.8 EC50 = 160 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
486 8 2 3 3.6 C1CCN(C1)CCCC(=O)NCC2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3590207 fpr2_human Human No 6.8 EC50 = 160 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
502 8 2 4 3.9 CCOC(=O)C1CCN(CC1)C(=O)C(CC2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Br
CHEMBL3728805 fpr2_human Human No 6.8 EC50 = 160 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
486 8 2 3 3.6 C1CCN(C1)CCCC(=O)NCC2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL556625 fpr2_human Human No 5.8 EC50 = 1600 Funct
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
398 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Cl
CHEMBL556625 fpr2_human Human No 5.8 EC50 = 1600 Funct
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
398 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Cl
CHEMBL3589947 fpr2_human Human No 5.8 EC50 = 1600 Funct
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
544 9 4 5 5.6 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC(=NC=C5)F
CHEMBL556625 fpr2_human Human No 5.8 EC50 = 1600 Funct
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
398 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Cl
CHEMBL556625 fpr2_human Human No 5.8 EC50 = 1600 Funct
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
398 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Cl
CHEMBL3589947 fpr2_human Human No 5.8 EC50 = 1600 Funct
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
544 9 4 5 5.6 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC(=NC=C5)F
CHEMBL3733176 fpr2_human Human No 6.8 EC50 = 166 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
440 8 2 6 2.5 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=NC=C(S4)C#N)C35CC5
CHEMBL3733176 fpr2_human Human No 6.8 EC50 = 166 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
440 8 2 6 2.5 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=NC=C(S4)C#N)C35CC5
CHEMBL3730082 fpr2_human Human No 6.8 EC50 = 168 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
505 8 2 5 3.1 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC(=C(N=C4)Br)F)C35CC5
CHEMBL3731458 fpr2_human Human No 6.8 EC50 = 168 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
483 7 3 3 3.5 CC1=C(C=NN1)CCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3730082 fpr2_human Human No 6.8 EC50 = 168 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
505 8 2 5 3.1 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC(=C(N=C4)Br)F)C35CC5
CHEMBL3731458 fpr2_human Human No 6.8 EC50 = 168 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
483 7 3 3 3.5 CC1=C(C=NN1)CCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL554291 fpr2_human Human No 4.8 EC50 = 16800 Funct
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
423 8 1 6 2.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC(=C(C=C3)OC)OC
CHEMBL554291 fpr2_human Human No 4.8 EC50 = 16800 Funct
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
423 8 1 6 2.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC(=C(C=C3)OC)OC
CHEMBL2391443 fpr2_human Human No 4.8 EC50 = 16900 Funct
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
494 5 1 3 3.9 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)Cl)CC(=O)NC3=CC=C(C=C3)I
CHEMBL3730548 fpr2_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
451 4 3 5 2.3 C1CNCCC1NC(=O)C2C3C=CC(C2C(=O)NC4=NC=C(S4)Br)C35CC5
CHEMBL3729170 fpr2_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
487 8 2 4 3.0 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=NC=C(C=C4)Br)C35CC5
CHEMBL3728451 fpr2_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
518 9 3 4 3.6 CC(C)(C)OC(=O)NCCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3729552 fpr2_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
493 8 2 5 3.5 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=NC=C(S4)Br)C35CC5
CHEMBL3730548 fpr2_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
451 4 3 5 2.3 C1CNCCC1NC(=O)C2C3C=CC(C2C(=O)NC4=NC=C(S4)Br)C35CC5
CHEMBL3728451 fpr2_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
518 9 3 4 3.6 CC(C)(C)OC(=O)NCCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3729552 fpr2_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
493 8 2 5 3.5 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=NC=C(S4)Br)C35CC5
CHEMBL214216 fpr2_human Human Yes 6.8 EC50 = 170 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
368 4 2 4 1.9 CC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)SC
CHEMBL3731893 fpr2_human Human No 6.8 EC50 = 170 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
455 10 2 6 1.5 CC(=O)C1=COC(=N1)CNC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL214216 fpr2_human Human Yes 6.8 EC50 = 170 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
368 4 2 4 1.9 CC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)SC
CHEMBL3731893 fpr2_human Human No 6.8 EC50 = 170 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
455 10 2 6 1.5 CC(=O)C1=COC(=N1)CNC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL2391447 fpr2_human Human No 5.8 EC50 = 1700 Funct
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
485 7 2 6 3.5 CC1=NN(C(=O)C(=C1C(=O)C)NC2=CC=C(C=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL3589947 fprs1_mouse Mouse No 5.8 EC50 = 1700 Funct
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
544 9 4 5 5.6 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC(=NC=C5)F
CHEMBL3728843 fpr2_human Human No 6.8 EC50 = 173 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
412 9 2 4 2.1 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC=CO4)C35CC5
CHEMBL3728843 fpr2_human Human No 6.8 EC50 = 173 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
412 9 2 4 2.1 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC=CO4)C35CC5
CHEMBL3731251 fpr2_human Human No 6.8 EC50 = 174 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
526 7 3 5 4.1 C1CC12C3C=CC2C(C3C(=O)NCCCC4=NC5=CC=CC=C5N4)C(=O)NC6=NC=C(S6)Br
CHEMBL3731251 fpr2_human Human No 6.8 EC50 = 174 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
526 7 3 5 4.1 C1CC12C3C=CC2C(C3C(=O)NCCCC4=NC5=CC=CC=C5N4)C(=O)NC6=NC=C(S6)Br
CHEMBL3727975 fpr2_human Human No 5.8 EC50 = 1740 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
440 10 2 3 3.6 C1CCC(=CC1)CCNC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3727975 fpr2_human Human No 5.8 EC50 = 1740 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
440 10 2 3 3.6 C1CCC(=CC1)CCNC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3728062 fpr2_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
544 6 2 4 4.0 CC(C)(C)OC(=O)N1CCCC(C1)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3730013 fpr2_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
470 7 2 4 2.6 C1CC12C3C=CC2C(C3C(=O)NCCCN4C=NC=N4)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3728062 fpr2_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
544 6 2 4 4.0 CC(C)(C)OC(=O)N1CCCC(C1)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3730013 fpr2_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
470 7 2 4 2.6 C1CC12C3C=CC2C(C3C(=O)NCCCN4C=NC=N4)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3590073 fpr2_human Human No 5.8 EC50 = 1800 Funct
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid
526 9 4 4 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=CC=N5
CHEMBL3590071 fpr2_human Human No 5.8 EC50 = 1800 Funct
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid
526 9 4 4 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CN=CC=C5
CHEMBL560780 fpr2_human Human No 5.8 EC50 = 1800 Funct
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
489 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)I
CHEMBL560780 fpr2_human Human No 5.8 EC50 = 1800 Funct
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
489 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)I
CHEMBL3732842 fpr2_human Human No 5.8 EC50 = 1800 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
450 9 2 3 3.7 CC1=CC(=C(C=C1)CNC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5)C
CHEMBL3590073 fpr2_human Human No 5.8 EC50 = 1800 Funct
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid
526 9 4 4 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=CC=N5
CHEMBL3590071 fpr2_human Human No 5.8 EC50 = 1800 Funct
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid
526 9 4 4 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CN=CC=C5
CHEMBL560780 fpr2_human Human No 5.8 EC50 = 1800 Funct
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
489 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)I
CHEMBL560780 fpr2_human Human No 5.8 EC50 = 1800 Funct
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
489 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)I
CHEMBL3732842 fpr2_human Human No 5.8 EC50 = 1800 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
450 9 2 3 3.7 CC1=CC(=C(C=C1)CNC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5)C
CHEMBL3733127 fpr2_human Human No 6.7 EC50 = 181 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
487 7 3 3 1.6 C1CC12C3C=CC2C(C3C(=O)NCCN4CCNC4=O)C(=O)NCC5=CC=C(C=C5)Br
CHEMBL3733127 fpr2_human Human No 6.7 EC50 = 181 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
487 7 3 3 1.6 C1CC12C3C=CC2C(C3C(=O)NCCN4CCNC4=O)C(=O)NCC5=CC=C(C=C5)Br
CHEMBL400723 fpr2_human Human No 5.7 EC50 = 1870 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
389 4 1 4 3.4 CCC1=NC2=CC=CC=C2N1C3CCN(C3)C(=O)C4=NC5=C(N4)C=C(C=C5)OC
CHEMBL400723 fpr2_human Human No 5.7 EC50 = 1870 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
389 4 1 4 3.4 CCC1=NC2=CC=CC=C2N1C3CCN(C3)C(=O)C4=NC5=C(N4)C=C(C=C5)OC
CHEMBL3729077 fpr2_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
432 7 3 3 2.3 C1CC12C3C=CC2C(C3C(=O)NCCCCN)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3727924 fpr2_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
465 4 2 5 2.2 C1CN(CCC1CN)C(=O)C2C3C=CC(C2C(=O)NC4=NC=C(S4)Br)C35CC5
CHEMBL3731599 fpr2_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
483 6 3 3 3.5 CC1=C(N=C(N1)CCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5)C
CHEMBL3729077 fpr2_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
432 7 3 3 2.3 C1CC12C3C=CC2C(C3C(=O)NCCCCN)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3727924 fpr2_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
465 4 2 5 2.2 C1CN(CCC1CN)C(=O)C2C3C=CC(C2C(=O)NC4=NC=C(S4)Br)C35CC5
CHEMBL3731599 fpr2_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
483 6 3 3 3.5 CC1=C(N=C(N1)CCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5)C
CHEMBL3588871 fpr2_human Human No 6.7 EC50 = 190 Funct
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilizationAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization
556 10 4 5 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=NC=C(C=C5)OC
CHEMBL549570 fpr2_human Human No 5.7 EC50 = 1900 Funct
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
431 6 1 7 3.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL549570 fpr2_human Human No 5.7 EC50 = 1900 Funct
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
431 6 1 7 3.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL549570 fpr2_human Human No 5.7 EC50 = 1900 Funct
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
431 6 1 7 3.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL549570 fpr2_human Human No 5.7 EC50 = 1900 Funct
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
431 6 1 7 3.5 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL3728883 fpr2_human Human No 6.7 EC50 = 191 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
503 9 2 4 3.7 CC(C)(C)OC(=O)CCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3728826 fpr2_human Human No 6.7 EC50 = 191 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
431 6 2 2 3.8 CC(C)CNC(=O)C1C2C=CC(C1C(=O)NCC3=CC=C(C=C3)Br)C24CC4
CHEMBL3728883 fpr2_human Human No 6.7 EC50 = 191 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
503 9 2 4 3.7 CC(C)(C)OC(=O)CCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3728826 fpr2_human Human No 6.7 EC50 = 191 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
431 6 2 2 3.8 CC(C)CNC(=O)C1C2C=CC(C1C(=O)NCC3=CC=C(C=C3)Br)C24CC4
CHEMBL2408791 fpr2_human Human No 4.7 EC50 = 19315 Funct
Modulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assayModulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assay
386 7 4 4 2.3 CCC(C)C(C(=O)NCC(=O)O)NC(=O)NC1=CC=C(C=C1)Br
CHEMBL3728708 fpr2_human Human No 6.7 EC50 = 194 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
581 10 3 5 4.9 CC(C)(C)OC(=O)CNC1=CC=CC(=C1)CNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728708 fpr2_human Human No 6.7 EC50 = 194 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
581 10 3 5 4.9 CC(C)(C)OC(=O)CNC1=CC=CC(=C1)CNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3733084 fpr2_human Human No 8.7 EC50 = 2 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
444 5 3 3 2.7 C1CC(NC1)CNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728297 fpr2_human Human No 8.7 EC50 = 2 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
438 9 2 4 3.0 COC1=CC=C(C=C1)NC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3733084 fpr2_human Human No 8.7 EC50 = 2 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
444 5 3 3 2.7 C1CC(NC1)CNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3729130 fpr2_human Human No 8.7 EC50 = 2.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
467 5 3 5 3.3 C1CCNC(C1)CNC(=O)C2C3CCC(C2C(=O)NC4=NC=C(S4)Br)C35CC5
CHEMBL3729758 fpr2_human Human No 8.7 EC50 = 2.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
527 6 2 3 4.6 C1CCN(C1)CC2CCC(CC2)NC(=O)C3C4C=CC(C3C(=O)NC5=CC=C(C=C5)Br)C46CC6
CHEMBL3732371 fpr2_human Human No 8.7 EC50 = 2.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
527 6 2 3 4.6 C1CCN(C1)CC2CCC(CC2)NC(=O)C3C4C=CC(C3C(=O)NC5=CC=C(C=C5)Br)C46CC6
CHEMBL3728238 fpr2_human Human No 8.7 EC50 = 2.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
515 8 2 3 4.6 CC1CCC(N1CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5)C
CHEMBL3729130 fpr2_human Human No 8.7 EC50 = 2.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
467 5 3 5 3.3 C1CCNC(C1)CNC(=O)C2C3CCC(C2C(=O)NC4=NC=C(S4)Br)C35CC5
CHEMBL3728238 fpr2_human Human No 8.7 EC50 = 2.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
515 8 2 3 4.6 CC1CCC(N1CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5)C
CHEMBL3731035 fpr2_human Human No 8.6 EC50 = 2.3 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
530 9 2 4 3.5 CCN1CCN(CC1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3731035 fpr2_human Human No 8.6 EC50 = 2.3 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
530 9 2 4 3.5 CCN1CCN(CC1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL2408792 fpr2_human Human No 8.6 EC50 = 2.3 Funct
Modulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assayModulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assay
403 7 4 7 3.1 CC(C)CC(C(=O)NC(C)(C)C(=O)O)NC(=O)NC1=CC=C(C=C1)C(F)(F)F
CHEMBL3729752 fpr2_human Human No 8.6 EC50 = 2.4 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
443 4 2 5 3.6 C1CC12C3C=CC2C(C3C(=O)NCC(F)(F)F)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3732225 fpr2_human Human No 8.6 EC50 = 2.4 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
475 6 3 3 2.3 C1CC2C(C(C1C23CC3)C(=O)NCCN4CCNC4=O)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3729752 fpr2_human Human No 8.6 EC50 = 2.4 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
443 4 2 5 3.6 C1CC12C3C=CC2C(C3C(=O)NCC(F)(F)F)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3732225 fpr2_human Human No 8.6 EC50 = 2.4 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
475 6 3 3 2.3 C1CC2C(C(C1C23CC3)C(=O)NCCN4CCNC4=O)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3729306 fpr2_human Human No 8.6 EC50 = 2.7 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
528 6 2 4 3.5 C1CCN(C1)CC2CCC(CO2)NC(=O)C3C4C=CC(C3C(=O)NC5=CC=C(C=C5)Br)C46CC6
CHEMBL3731469 fpr2_human Human No 8.6 EC50 = 2.7 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
407 5 2 3 2.9 C1CC12C3C=CC2C(C3C(=O)NCCF)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3729306 fpr2_human Human No 8.6 EC50 = 2.7 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
528 6 2 4 3.5 C1CCN(C1)CC2CCC(CO2)NC(=O)C3C4C=CC(C3C(=O)NC5=CC=C(C=C5)Br)C46CC6
CHEMBL3731469 fpr2_human Human No 8.6 EC50 = 2.7 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
407 5 2 3 2.9 C1CC12C3C=CC2C(C3C(=O)NCCF)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3730502 fpr2_human Human No 8.6 EC50 = 2.8 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
418 6 3 3 2.1 CNCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3730502 fpr2_human Human No 8.6 EC50 = 2.8 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
418 6 3 3 2.1 CNCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3729170 fpr2_human Human No 8.5 EC50 = 2.9 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
487 8 2 4 3.0 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=NC=C(C=C4)Br)C35CC5
CHEMBL3729170 fpr2_human Human No 8.5 EC50 = 2.9 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
487 8 2 4 3.0 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=NC=C(C=C4)Br)C35CC5
CHEMBL3728852 fpr2_human Human No 7.7 EC50 = 20 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
431 6 2 2 4.2 CC(C)CCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3728852 fpr2_human Human No 7.7 EC50 = 20 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
431 6 2 2 4.2 CC(C)CCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3728585 fpr2_human Human No 6.7 EC50 = 200 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
443 5 2 2 4.4 C1CCC(C1)C(=O)NCC2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728613 fpr2_human Human No 6.7 EC50 = 200 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
457 7 1 2 4.3 CCCN(CC1CC1)C(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728585 fpr2_human Human No 6.7 EC50 = 200 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
443 5 2 2 4.4 C1CCC(C1)C(=O)NCC2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728613 fpr2_human Human No 6.7 EC50 = 200 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
457 7 1 2 4.3 CCCN(CC1CC1)C(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728389 fpr2_human Human No 6.7 EC50 = 204 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
559 7 2 4 4.2 CC(C)(C)OC(=O)N1CCC(CC1)CNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728389 fpr2_human Human No 6.7 EC50 = 204 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
559 7 2 4 4.2 CC(C)(C)OC(=O)N1CCC(CC1)CNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL267179 fpr2_human Human Yes 4.7 EC50 = 20400 Funct
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
None None None CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC=O
CHEMBL267179 fpr2_human Human Yes 4.7 EC50 = 20400 Funct
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
None None None CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC=O
CHEMBL3729633 fpr2_human Human No 5.7 EC50 = 2060 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
500 9 2 3 3.7 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC(=CC=C4)Br)C35CC5
CHEMBL3729633 fpr2_human Human No 5.7 EC50 = 2060 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
500 9 2 3 3.7 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC(=CC=C4)Br)C35CC5
CHEMBL3729758 fpr2_human Human No 6.7 EC50 = 208 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
527 6 2 3 4.6 C1CCN(C1)CC2CCC(CC2)NC(=O)C3C4C=CC(C3C(=O)NC5=CC=C(C=C5)Br)C46CC6
CHEMBL3732371 fpr2_human Human No 6.7 EC50 = 208 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
527 6 2 3 4.6 C1CCN(C1)CC2CCC(CC2)NC(=O)C3C4C=CC(C3C(=O)NC5=CC=C(C=C5)Br)C46CC6
CHEMBL3729758 fpr2_human Human No 6.7 EC50 = 208 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
527 6 2 3 4.6 C1CCN(C1)CC2CCC(CC2)NC(=O)C3C4C=CC(C3C(=O)NC5=CC=C(C=C5)Br)C46CC6
CHEMBL3732371 fpr2_human Human No 6.7 EC50 = 208 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
527 6 2 3 4.6 C1CCN(C1)CC2CCC(CC2)NC(=O)C3C4C=CC(C3C(=O)NC5=CC=C(C=C5)Br)C46CC6
CHEMBL3727620 fpr2_human Human No 7.7 EC50 = 21 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
456 10 2 5 2.8 CC(=O)C1=CC=C(O1)CNC(=O)C2C3CCC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3730283 fpr2_human Human No 7.7 EC50 = 21 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
461 7 3 3 3.6 CC(C)CC(CO)NC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3727620 fpr2_human Human No 7.7 EC50 = 21 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
456 10 2 5 2.8 CC(=O)C1=CC=C(O1)CNC(=O)C2C3CCC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3730283 fpr2_human Human No 7.7 EC50 = 21 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
461 7 3 3 3.6 CC(C)CC(CO)NC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL551589 fpr2_human Human No 5.7 EC50 = 2100 Funct
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL551589 fpr2_human Human No 5.7 EC50 = 2100 Funct
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL3590072 fprs1_mouse Mouse No 5.7 EC50 = 2100 Funct
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
526 9 4 4 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CN=CC=C5
CHEMBL551589 fpr2_human Human No 5.7 EC50 = 2100 Funct
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL551589 fpr2_human Human No 5.7 EC50 = 2100 Funct
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL3730632 fpr2_human Human No 6.7 EC50 = 213 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
515 8 2 4 2.7 CN1CCN(CC1)CCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC=C(C=C4)Br)C35CC5
CHEMBL3727792 fpr2_human Human No 6.7 EC50 = 213 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
507 9 2 5 3.1 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CN=C(S4)Br)C35CC5
CHEMBL3730632 fpr2_human Human No 6.7 EC50 = 213 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
515 8 2 4 2.7 CN1CCN(CC1)CCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC=C(C=C4)Br)C35CC5
CHEMBL3727792 fpr2_human Human No 6.7 EC50 = 213 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
507 9 2 5 3.1 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CN=C(S4)Br)C35CC5
CHEMBL3728352 fpr2_human Human No 6.7 EC50 = 216 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
533 8 3 3 4.4 C1CC12C3C=CC2C(C3C(=O)NCCCC4=NC5=CC=CC=C5N4)C(=O)NCC6=CC=C(C=C6)Br
CHEMBL3730033 fpr2_human Human No 6.7 EC50 = 216 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
443 4 2 2 4.3 C1CCC(CC1)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728352 fpr2_human Human No 6.7 EC50 = 216 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
533 8 3 3 4.4 C1CC12C3C=CC2C(C3C(=O)NCCCC4=NC5=CC=CC=C5N4)C(=O)NCC6=CC=C(C=C6)Br
CHEMBL3730033 fpr2_human Human No 6.7 EC50 = 216 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
443 4 2 2 4.3 C1CCC(CC1)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3730306 fpr2_human Human No 6.7 EC50 = 218 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
544 6 2 4 4.0 CC(C)(C)OC(=O)N1CCC(CC1)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3730306 fpr2_human Human No 6.7 EC50 = 218 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
544 6 2 4 4.0 CC(C)(C)OC(=O)N1CCC(CC1)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3732895 fpr2_human Human No 7.7 EC50 = 22 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
447 7 2 4 2.3 COC(=O)CCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3729885 fpr2_human Human No 7.7 EC50 = 22 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
480 9 3 4 3.3 C1CC2C(C(C1C23CC3)C(=O)NCCCCCN)C(=O)NCC4=C(C=C(C=C4)Br)F
CHEMBL3727795 fpr2_human Human No 7.7 EC50 = 22 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
495 8 2 5 4.1 C1CCN(C1)CCCCNC(=O)C2C3CCC(C2C(=O)NC4=NC=C(S4)Br)C35CC5
CHEMBL3732895 fpr2_human Human No 7.7 EC50 = 22 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
447 7 2 4 2.3 COC(=O)CCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3729885 fpr2_human Human No 7.7 EC50 = 22 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
480 9 3 4 3.3 C1CC2C(C(C1C23CC3)C(=O)NCCCCCN)C(=O)NCC4=C(C=C(C=C4)Br)F
CHEMBL3727795 fpr2_human Human No 7.7 EC50 = 22 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
495 8 2 5 4.1 C1CCN(C1)CCCCNC(=O)C2C3CCC(C2C(=O)NC4=NC=C(S4)Br)C35CC5
CHEMBL3728553 fpr2_human Human No 6.7 EC50 = 223 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
508 7 3 3 3.5 C1CC12C3C=CC2C(C3C(=O)NC4=CC=C(C=C4)Br)C(=O)NC(CC5=CC=CC=C5)C(=O)N
CHEMBL3729225 fpr2_human Human No 6.7 EC50 = 223 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
470 10 2 5 2.7 CC(=O)C1=CC=C(S1)CNC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3728553 fpr2_human Human No 6.7 EC50 = 223 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
508 7 3 3 3.5 C1CC12C3C=CC2C(C3C(=O)NC4=CC=C(C=C4)Br)C(=O)NC(CC5=CC=CC=C5)C(=O)N
CHEMBL3729225 fpr2_human Human No 6.7 EC50 = 223 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
470 10 2 5 2.7 CC(=O)C1=CC=C(S1)CNC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3730819 fpr2_human Human No 5.6 EC50 = 2270 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
465 8 2 5 3.9 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=NC5=CC=CC=C5S4)C36CC6
CHEMBL3730819 fpr2_human Human No 5.6 EC50 = 2270 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
465 8 2 5 3.9 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=NC5=CC=CC=C5S4)C36CC6
CHEMBL377226 fpr2_human Human No 7.6 EC50 = 23 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
399 4 2 3 4.7 CC(C)(C)C1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Cl
CHEMBL3733264 fpr2_human Human No 7.6 EC50 = 23 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
544 7 3 5 3.0 C1CC12C3C=CC2C(C3C(=O)NCCC4=CC=C(C=C4)S(=O)(=O)N)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3728546 fpr2_human Human No 7.6 EC50 = 23 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
458 5 3 3 2.6 C1CNCCC1NC(=O)C2C3C=CC(C2C(=O)NCC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728508 fpr2_human Human No 7.6 EC50 = 23 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
450 9 2 4 2.8 CC(=O)C1=CC=C(C=C1)NC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL377226 fpr2_human Human No 7.6 EC50 = 23 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
399 4 2 3 4.7 CC(C)(C)C1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Cl
CHEMBL3733264 fpr2_human Human No 7.6 EC50 = 23 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
544 7 3 5 3.0 C1CC12C3C=CC2C(C3C(=O)NCCC4=CC=C(C=C4)S(=O)(=O)N)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3728546 fpr2_human Human No 7.6 EC50 = 23 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
458 5 3 3 2.6 C1CNCCC1NC(=O)C2C3C=CC(C2C(=O)NCC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728508 fpr2_human Human No 7.6 EC50 = 23 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
450 9 2 4 2.8 CC(=O)C1=CC=C(C=C1)NC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3589946 fpr2_human Human No 6.6 EC50 = 230 Funct
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
556 10 4 5 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=NC=C(C=C5)OC
CHEMBL3589946 fpr2_human Human No 6.6 EC50 = 230 Funct
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
556 10 4 5 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=NC=C(C=C5)OC
CHEMBL3590075 fprs1_mouse Mouse No 5.6 EC50 = 2300 Funct
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
543 9 4 4 6.3 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=C(C=C5)F
CHEMBL3589948 fprs1_mouse Mouse No 5.6 EC50 = 2300 Funct
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
544 9 4 5 5.6 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC(=NC=C5)F
CHEMBL3730781 fpr2_human Human No 6.6 EC50 = 236 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
522 8 2 5 4.0 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=C(C(=C(C=C4)Br)F)F)C35CC5
CHEMBL3730781 fpr2_human Human No 6.6 EC50 = 236 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
522 8 2 5 4.0 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=C(C(=C(C=C4)Br)F)F)C35CC5
CHEMBL3728771 fpr2_human Human No 7.6 EC50 = 24 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
391 6 3 4 1.2 C1CC2C(C(C1C23CC3)C(=O)NCCC(=O)N)C(=O)NC4=CN=C(C=C4)Cl
CHEMBL3730881 fpr2_human Human No 7.6 EC50 = 24 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
497 7 2 3 3.5 CCN1C(=CC(=N1)CCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5)C
CHEMBL3729082 fpr2_human Human No 7.6 EC50 = 24 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
518 9 2 4 3.8 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=C(C=C(C=C4)Br)F)C35CC5
CHEMBL3727426 fpr2_human Human No 7.6 EC50 = 24 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
477 9 1 4 2.4 COCCN(CCOC)C(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3732094 fpr2_human Human No 7.6 EC50 = 24 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
453 4 3 5 3.0 C1CC2C(C(C1C23CC3)C(=O)NC4CCNCC4)C(=O)NC5=NC=C(S5)Br
CHEMBL3728771 fpr2_human Human No 7.6 EC50 = 24 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
391 6 3 4 1.2 C1CC2C(C(C1C23CC3)C(=O)NCCC(=O)N)C(=O)NC4=CN=C(C=C4)Cl
CHEMBL3730881 fpr2_human Human No 7.6 EC50 = 24 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
497 7 2 3 3.5 CCN1C(=CC(=N1)CCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5)C
CHEMBL3732094 fpr2_human Human No 7.6 EC50 = 24 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
453 4 3 5 3.0 C1CC2C(C(C1C23CC3)C(=O)NC4CCNCC4)C(=O)NC5=NC=C(S5)Br
CHEMBL3730424 fpr2_human Human No 6.6 EC50 = 240 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
446 7 3 3 1.3 C1CC12C3C=CC2C(C3C(=O)NCCC(=O)N)C(=O)NCC4=CC=C(C=C4)Br
CHEMBL3588871 fprs1_mouse Mouse No 6.6 EC50 = 240 Funct
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
556 10 4 5 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=NC=C(C=C5)OC
CHEMBL3730424 fpr2_human Human No 6.6 EC50 = 240 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
446 7 3 3 1.3 C1CC12C3C=CC2C(C3C(=O)NCCC(=O)N)C(=O)NCC4=CC=C(C=C4)Br
CHEMBL562380 fpr2_human Human No 5.6 EC50 = 2400 Funct
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC=C(C=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL562380 fpr2_human Human No 5.6 EC50 = 2400 Funct
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC=C(C=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL379853 fpr2_human Human No 6.6 EC50 = 250 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
387 4 2 5 2.4 CC(C)C1=C(C(=O)N(N1C)C2=CN=CN=C2)NC(=O)NC3=CC=C(C=C3)Cl
CHEMBL3590208 fpr2_human Human No 6.6 EC50 = 250 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
464 5 2 2 4.7 C1CN(C2=CC=CC=C21)C(=O)C(CC3=CC=CC=C3)NC(=O)NC4=CC=C(C=C4)Br
CHEMBL379853 fpr2_human Human No 6.6 EC50 = 250 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
387 4 2 5 2.4 CC(C)C1=C(C(=O)N(N1C)C2=CN=CN=C2)NC(=O)NC3=CC=C(C=C3)Cl
CHEMBL3590208 fpr2_human Human No 6.6 EC50 = 250 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
464 5 2 2 4.7 C1CN(C2=CC=CC=C21)C(=O)C(CC3=CC=CC=C3)NC(=O)NC4=CC=C(C=C4)Br
CHEMBL3590069 fprs1_mouse Mouse No 5.6 EC50 = 2500 Funct
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
525 9 4 3 6.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=CC=C5
CHEMBL3590076 fprs1_mouse Mouse No 5.6 EC50 = 2500 Funct
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
543 9 4 4 6.3 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=C(C=C5)F
CHEMBL3731676 fpr2_human Human No 6.6 EC50 = 252 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
486 6 2 4 3.9 CC1=NC(=CS1)CC(=O)NCC2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3731676 fpr2_human Human No 6.6 EC50 = 252 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
486 6 2 4 3.9 CC1=NC(=CS1)CC(=O)NCC2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3733330 fpr2_human Human No 6.6 EC50 = 258 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
447 7 3 4 0.3 C1CC12C3C=CC2C(C3C(=O)NCCC(=O)N)C(=O)NCC4=NC=C(C=C4)Br
CHEMBL3733330 fpr2_human Human No 6.6 EC50 = 258 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
447 7 3 4 0.3 C1CC12C3C=CC2C(C3C(=O)NCCC(=O)N)C(=O)NCC4=NC=C(C=C4)Br
CHEMBL3728857 fpr2_human Human No 7.6 EC50 = 26 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
460 7 3 3 2.7 CC(C)(CN)CNC(=O)C1C2C=CC(C1C(=O)NCC3=CC=C(C=C3)Br)C24CC4
CHEMBL3733280 fpr2_human Human No 7.6 EC50 = 26 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
432 5 3 3 1.9 CC(C(=O)N)NC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3728857 fpr2_human Human No 7.6 EC50 = 26 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
460 7 3 3 2.7 CC(C)(CN)CNC(=O)C1C2C=CC(C1C(=O)NCC3=CC=C(C=C3)Br)C24CC4
CHEMBL3733280 fpr2_human Human No 7.6 EC50 = 26 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
432 5 3 3 1.9 CC(C(=O)N)NC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3590070 fpr2_human Human No 6.6 EC50 = 260 Funct
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
525 9 4 3 6.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=CC=C5
CHEMBL3590070 fpr2_human Human No 6.6 EC50 = 260 Funct
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
525 9 4 3 6.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=CC=C5
CHEMBL3729208 fpr2_human Human No 6.6 EC50 = 263 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
492 9 2 7 4.3 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)OC(F)(F)F)C35CC5
CHEMBL3729208 fpr2_human Human No 6.6 EC50 = 263 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
492 9 2 7 4.3 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)OC(F)(F)F)C35CC5
CHEMBL3729083 fpr2_human Human No 6.6 EC50 = 265 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
432 6 2 3 2.9 CN(C)CC(=O)NCC1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3729083 fpr2_human Human No 6.6 EC50 = 265 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
432 6 2 3 2.9 CN(C)CC(=O)NCC1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3731561 fpr2_human Human No 7.6 EC50 = 27 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
547 11 3 4 4.3 CC(C)(C)OC(=O)NCCCCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3731561 fpr2_human Human No 7.6 EC50 = 27 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
547 11 3 4 4.3 CC(C)(C)OC(=O)NCCCCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3590071 fpr2_human Human No 6.6 EC50 = 270 Funct
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
526 9 4 4 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CN=CC=C5
CHEMBL249742 fpr2_human Human No 6.6 EC50 = 270 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
386 4 1 2 4.8 CCC1=CC2=C(C=C1)NC(=C2)C(=O)N3CCC(C3)N4C5=CC=CC=C5N=C4CC
CHEMBL3590071 fpr2_human Human No 6.6 EC50 = 270 Funct
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
526 9 4 4 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CN=CC=C5
CHEMBL249742 fpr2_human Human No 6.6 EC50 = 270 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
386 4 1 2 4.8 CCC1=CC2=C(C=C1)NC(=C2)C(=O)N3CCC(C3)N4C5=CC=CC=C5N=C4CC
CHEMBL401313 fpr2_human Human No 5.6 EC50 = 2710 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
451 4 1 3 5.1 COC1=CC2=C(C=C1)NC(=C2)C(=O)N3CCC(CC3)N4C5=CC=CC=C5N=C4C6=CC=CC=C6
CHEMBL401313 fpr2_human Human No 5.6 EC50 = 2710 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
451 4 1 3 5.1 COC1=CC2=C(C=C1)NC(=C2)C(=O)N3CCC(CC3)N4C5=CC=CC=C5N=C4C6=CC=CC=C6
CHEMBL2391440 fpr2_human Human No 4.6 EC50 = 27200 Funct
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
455 6 2 4 2.2 CC1=NN(C(=O)C(=C1)CC2=CC=C(C=C2)C(=O)N)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL3729427 fpr2_human Human No 6.6 EC50 = 273 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
403 8 3 6 0.3 CC(=O)C1=CSC(=N1)CNC(=O)C2C3C=CC(C2C(=O)NCCCN)C34CC4
CHEMBL3729427 fpr2_human Human No 6.6 EC50 = 273 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
403 8 3 6 0.3 CC(=O)C1=CSC(=N1)CNC(=O)C2C3C=CC(C2C(=O)NCCCN)C34CC4
CHEMBL377642 fpr2_human Human Yes 5.6 EC50 = 2730 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
352 4 2 4 1.4 CC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)OC
CHEMBL377642 fpr2_human Human Yes 5.6 EC50 = 2730 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
352 4 2 4 1.4 CC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)OC
CHEMBL3730378 fpr2_human Human No 6.6 EC50 = 275 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
500 8 2 3 4.1 CC1=C(C=CC(=C1)Br)NC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3730378 fpr2_human Human No 6.6 EC50 = 275 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
500 8 2 3 4.1 CC1=C(C=CC(=C1)Br)NC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3732960 fpr2_human Human No 7.6 EC50 = 28 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
454 10 2 5 2.1 CC(=O)C1=CC=C(O1)CNC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3729342 fpr2_human Human No 7.6 EC50 = 28 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
536 9 2 5 3.9 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=C(C=C(C=C4F)Br)F)C35CC5
CHEMBL3732960 fpr2_human Human No 7.6 EC50 = 28 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
454 10 2 5 2.1 CC(=O)C1=CC=C(O1)CNC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3729342 fpr2_human Human No 7.6 EC50 = 28 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
536 9 2 5 3.9 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=C(C=C(C=C4F)Br)F)C35CC5
CHEMBL2391450 fpr2_human Human No 5.6 EC50 = 2800 Funct
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
471 6 2 5 2.4 CC1=NN(C(=O)C(=C1)NC(=O)C2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL2391439 fpr2_human Human No 5.6 EC50 = 2800 Funct
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
413 5 1 4 2.2 CC1=NN(C(=O)C(=C1)CC2=CN=CC=C2)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL3590073 fprs1_mouse Mouse No 5.6 EC50 = 2800 Funct
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
526 9 4 4 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=CC=N5
CHEMBL3733076 fpr2_human Human No 6.5 EC50 = 288 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
431 9 2 6 1.3 CC(=O)C1=CSC(=N1)CNC(=O)C2C3C=CC(C2C(=O)NCCCN(C)C)C34CC4
CHEMBL3733076 fpr2_human Human No 6.5 EC50 = 288 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
431 9 2 6 1.3 CC(=O)C1=CSC(=N1)CNC(=O)C2C3C=CC(C2C(=O)NCCCN(C)C)C34CC4
CHEMBL3727453 fpr2_human Human No 6.5 EC50 = 290 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
446 7 2 3 2.5 CN(C)CCNC(=O)C1C2C=CC(C1C(=O)NCC3=CC=C(C=C3)Br)C24CC4
CHEMBL3727453 fpr2_human Human No 6.5 EC50 = 290 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
446 7 2 3 2.5 CN(C)CCNC(=O)C1C2C=CC(C1C(=O)NCC3=CC=C(C=C3)Br)C24CC4
CHEMBL2391448 fpr2_human Human No 4.5 EC50 = 29400 Funct
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
337 3 2 4 0.9 CC1=NN(C(=O)C(=C1)N)CC(=O)NC2=CC=C(C=C2)Br
CHEMBL3729761 fpr2_human Human No 6.5 EC50 = 297 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
416 8 3 6 -0.3 CC(=O)C1=CSC(=N1)CNC(=O)C2C3C=CC(C2C(=O)NCCC(=O)N)C34CC4
CHEMBL3729761 fpr2_human Human No 6.5 EC50 = 297 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
416 8 3 6 -0.3 CC(=O)C1=CSC(=N1)CNC(=O)C2C3C=CC(C2C(=O)NCCC(=O)N)C34CC4
CHEMBL3732583 fpr2_human Human No 6.5 EC50 = 298 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
514 6 1 2 5.2 CN(CC1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4)C(=O)CC5=CC=CC=C5Cl
CHEMBL3732583 fpr2_human Human No 6.5 EC50 = 298 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
514 6 1 2 5.2 CN(CC1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4)C(=O)CC5=CC=CC=C5Cl
CHEMBL3730852 fpr2_human Human No 8.5 EC50 = 3.2 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
446 6 3 3 1.8 CNC(=O)CCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3730354 fpr2_human Human No 8.5 EC50 = 3.2 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
445 5 2 3 2.9 C1CC(OC1)CNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3730852 fpr2_human Human No 8.5 EC50 = 3.2 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
446 6 3 3 1.8 CNC(=O)CCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3730354 fpr2_human Human No 8.5 EC50 = 3.2 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
445 5 2 3 2.9 C1CC(OC1)CNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728753 fpr2_human Human No 8.5 EC50 = 3.3 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
473 5 3 3 3.4 C1CC(CCC1CNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5)O
CHEMBL3728753 fpr2_human Human No 8.5 EC50 = 3.3 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
473 5 3 3 3.4 C1CC(CCC1CNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5)O
CHEMBL3727840 fpr2_human Human No 8.5 EC50 = 3.4 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
460 6 2 3 2.0 CN(C)C(=O)CCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3727840 fpr2_human Human No 8.5 EC50 = 3.4 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
460 6 2 3 2.0 CN(C)C(=O)CCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3730279 fpr2_human Human No 8.4 EC50 = 3.7 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
449 7 2 3 3.5 CCSCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3730279 fpr2_human Human No 8.4 EC50 = 3.7 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
449 7 2 3 3.5 CCSCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3728562 fpr2_human Human No 8.4 EC50 = 3.9 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
438 6 2 4 3.2 CC(C)CNC(=O)C1C2C=CC(C1C(=O)NCC3=NC=C(S3)Br)C24CC4
CHEMBL3732049 fpr2_human Human No 8.4 EC50 = 3.9 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
502 10 2 3 4.4 CCN(CC)CCCC(C)NC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3728562 fpr2_human Human No 8.4 EC50 = 3.9 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
438 6 2 4 3.2 CC(C)CNC(=O)C1C2C=CC(C1C(=O)NCC3=NC=C(S3)Br)C24CC4
CHEMBL3732049 fpr2_human Human No 8.4 EC50 = 3.9 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
502 10 2 3 4.4 CCN(CC)CCCC(C)NC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL208884 fpr2_human Human No 7.5 EC50 = 30 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
448 3 2 3 2.0 CC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)I
CHEMBL379762 fpr2_human Human No 7.5 EC50 = 30 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
448 5 2 5 4.3 CC(C)C1=C(C(=O)N(N1C)C2=CC3=CC=CC=C3N=C2)NC(=O)NC4=CC=C(C=C4)SC
CHEMBL3733340 fpr2_human Human No 7.5 EC50 = 30 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
446 8 3 3 2.7 C1CC12C3C=CC2C(C3C(=O)NCCCCCN)C(=O)NC4=CC=C(C=C4)Br
CHEMBL208884 fpr2_human Human No 7.5 EC50 = 30 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
448 3 2 3 2.0 CC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)I
CHEMBL379762 fpr2_human Human No 7.5 EC50 = 30 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
448 5 2 5 4.3 CC(C)C1=C(C(=O)N(N1C)C2=CC3=CC=CC=C3N=C2)NC(=O)NC4=CC=C(C=C4)SC
CHEMBL3733340 fpr2_human Human No 7.5 EC50 = 30 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
446 8 3 3 2.7 C1CC12C3C=CC2C(C3C(=O)NCCCCCN)C(=O)NC4=CC=C(C=C4)Br
CHEMBL3588928 fpr2_human Human No 6.5 EC50 = 300 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
398 6 2 3 3.8 CSC1=CC=C(C=C1)NC(=O)NC(CC2=CC=CC=C2)C(=O)N3CCCCC3
CHEMBL3588924 fpr2_human Human No 6.5 EC50 = 300 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
556 8 4 5 3.8 CC1CN(CCC1C(=O)ONC)C(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)NC4=CC=C(C=C4)Br
CHEMBL3588928 fpr2_human Human No 6.5 EC50 = 300 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
398 6 2 3 3.8 CSC1=CC=C(C=C1)NC(=O)NC(CC2=CC=CC=C2)C(=O)N3CCCCC3
CHEMBL3588924 fpr2_human Human No 6.5 EC50 = 300 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
556 8 4 5 3.8 CC1CN(CCC1C(=O)ONC)C(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)NC4=CC=C(C=C4)Br
CHEMBL1288648 fpr2_human Human Yes 5.5 EC50 = 3000 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
270 5 2 2 3.2 COC1=CC=C(C=C1)CCNC(=O)NC2=CC=CC=C2
CHEMBL1288648 fpr2_human Human Yes 5.5 EC50 = 3000 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
270 5 2 2 3.2 COC1=CC=C(C=C1)CCNC(=O)NC2=CC=CC=C2
CHEMBL3731680 fpr2_human Human No 6.5 EC50 = 301 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
536 9 2 5 3.9 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC(=C(C=C4F)Br)F)C35CC5
CHEMBL3731680 fpr2_human Human No 6.5 EC50 = 301 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
536 9 2 5 3.9 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC(=C(C=C4F)Br)F)C35CC5
CHEMBL3732650 fpr2_human Human No 6.5 EC50 = 303 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
483 5 1 3 3.7 CC1=CC(=NN1C)C(=O)N(C)CC2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3732650 fpr2_human Human No 6.5 EC50 = 303 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
483 5 1 3 3.7 CC1=CC(=NN1C)C(=O)N(C)CC2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3727729 fpr2_human Human No 6.5 EC50 = 305 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
479 7 2 5 3.1 C1CCN(C1)CCCNC(=O)C2C3C=CC(C2C(=O)NC4=NC=C(S4)Br)C35CC5
CHEMBL3727729 fpr2_human Human No 6.5 EC50 = 305 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
479 7 2 5 3.1 C1CCN(C1)CCCNC(=O)C2C3C=CC(C2C(=O)NC4=NC=C(S4)Br)C35CC5
CHEMBL3730211 fpr2_human Human No 7.5 EC50 = 31 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
486 6 2 3 2.4 C1CCN(C1)C(=O)CCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3732192 fpr2_human Human No 7.5 EC50 = 31 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
403 7 3 4 0.5 C1CC12C3C=CC2C(C3C(=O)NCCC(=O)N)C(=O)NCC4=CN=C(C=C4)Cl
CHEMBL3730211 fpr2_human Human No 7.5 EC50 = 31 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
486 6 2 3 2.4 C1CCN(C1)C(=O)CCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3732192 fpr2_human Human No 7.5 EC50 = 31 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
403 7 3 4 0.5 C1CC12C3C=CC2C(C3C(=O)NCCC(=O)N)C(=O)NCC4=CN=C(C=C4)Cl
CHEMBL212113 fpr2_human Human No 6.5 EC50 = 310 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
368 4 2 4 3.7 CCC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC(=C(C=C3)C)F
CHEMBL3590074 fpr2_human Human No 6.5 EC50 = 310 Funct
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
526 9 4 4 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=CC=N5
CHEMBL212113 fpr2_human Human No 6.5 EC50 = 310 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
368 4 2 4 3.7 CCC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC(=C(C=C3)C)F
CHEMBL3590074 fpr2_human Human No 6.5 EC50 = 310 Funct
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
526 9 4 4 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=CC=N5
CHEMBL3728604 fpr2_human Human No 6.5 EC50 = 315 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
429 6 2 2 3.9 C1CC1CC(=O)NCC2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728604 fpr2_human Human No 6.5 EC50 = 315 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
429 6 2 2 3.9 C1CC1CC(=O)NCC2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728166 fpr2_human Human No 6.5 EC50 = 319 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
452 11 2 4 3.2 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCCOC4=CC=CC=C4)C35CC5
CHEMBL3728166 fpr2_human Human No 6.5 EC50 = 319 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
452 11 2 4 3.2 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCCOC4=CC=CC=C4)C35CC5
CHEMBL3728506 fpr2_human Human No 7.5 EC50 = 32 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
383 7 3 4 0.7 COC1=CC=C(C=C1)NC(=O)C2C3C=CC(C2C(=O)NCCC(=O)N)C34CC4
CHEMBL3729722 fpr2_human Human No 7.5 EC50 = 32 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
500 9 2 3 3.7 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728506 fpr2_human Human No 7.5 EC50 = 32 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
383 7 3 4 0.7 COC1=CC=C(C=C1)NC(=O)C2C3C=CC(C2C(=O)NCCC(=O)N)C34CC4
CHEMBL3729722 fpr2_human Human No 7.5 EC50 = 32 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
500 9 2 3 3.7 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC=C(C=C4)Br)C35CC5
CHEMBL3590211 fpr2_human Human Yes 5.5 EC50 = 3200 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
341 6 2 4 4.0 CCC1=CC=C(C=C1)NC(=O)CSC2=NC3=C(N2)C=C(C=C3)OC
CHEMBL3590211 fpr2_human Human Yes 5.5 EC50 = 3200 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
341 6 2 4 4.0 CCC1=CC=C(C=C1)NC(=O)CSC2=NC3=C(N2)C=C(C=C3)OC
CHEMBL3731244 fpr2_human Human No 5.5 EC50 = 3230 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
471 10 2 6 2.1 CC(=O)C1=NC(=CS1)CNC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3731244 fpr2_human Human No 5.5 EC50 = 3230 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
471 10 2 6 2.1 CC(=O)C1=NC(=CS1)CNC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3733287 fpr2_human Human No 7.5 EC50 = 33 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
507 9 2 4 3.7 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CSC(=C4)Br)C35CC5
CHEMBL3733287 fpr2_human Human No 7.5 EC50 = 33 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
507 9 2 4 3.7 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CSC(=C4)Br)C35CC5
CHEMBL3729765 fpr2_human Human No 6.5 EC50 = 330 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
368 6 3 4 0.3 CC1=CN=C(C=C1)NC(=O)C2C3C=CC(C2C(=O)NCCC(=O)N)C34CC4
CHEMBL3729765 fpr2_human Human No 6.5 EC50 = 330 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
368 6 3 4 0.3 CC1=CN=C(C=C1)NC(=O)C2C3C=CC(C2C(=O)NCCC(=O)N)C34CC4
CHEMBL3727702 fpr2_human Human No 6.5 EC50 = 333 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
442 5 3 5 2.8 CC(C)(CO)NC(=O)C1C2CCC(C1C(=O)NC3=NC=C(S3)Br)C24CC4
CHEMBL3727702 fpr2_human Human No 6.5 EC50 = 333 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
442 5 3 5 2.8 CC(C)(CO)NC(=O)C1C2CCC(C1C(=O)NC3=NC=C(S3)Br)C24CC4
CHEMBL3727668 fpr2_human Human No 6.5 EC50 = 336 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
533 7 2 3 4.3 CN1C2=CC=CC=C2N=C1CCC(=O)NCC3C4C=CC(C3C(=O)NC5=CC=C(C=C5)Br)C46CC6
CHEMBL3727668 fpr2_human Human No 6.5 EC50 = 336 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
533 7 2 3 4.3 CN1C2=CC=CC=C2N=C1CCC(=O)NCC3C4C=CC(C3C(=O)NC5=CC=C(C=C5)Br)C46CC6
CHEMBL3730231 fpr2_human Human No 7.5 EC50 = 34 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
460 8 2 3 3.3 CCN(CC)CCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3730944 fpr2_human Human No 7.5 EC50 = 34 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
431 7 2 2 4.3 CCCCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL249132 fpr2_human Human No 7.5 EC50 = 34 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
388 4 1 3 4.0 CCC1=NC2=CC=CC=C2N1C3CCN(C3)C(=O)C4=CC5=C(N4)C=CC(=C5)OC
CHEMBL3730231 fpr2_human Human No 7.5 EC50 = 34 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
460 8 2 3 3.3 CCN(CC)CCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3730944 fpr2_human Human No 7.5 EC50 = 34 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
431 7 2 2 4.3 CCCCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL249132 fpr2_human Human No 7.5 EC50 = 34 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
388 4 1 3 4.0 CCC1=NC2=CC=CC=C2N1C3CCN(C3)C(=O)C4=CC5=C(N4)C=CC(=C5)OC
CHEMBL3729916 fpr2_human Human No 6.5 EC50 = 350 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
432 7 3 3 2.0 CNCCNC(=O)C1C2C=CC(C1C(=O)NCC3=CC=C(C=C3)Br)C24CC4
CHEMBL3729916 fpr2_human Human No 6.5 EC50 = 350 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
432 7 3 3 2.0 CNCCNC(=O)C1C2C=CC(C1C(=O)NCC3=CC=C(C=C3)Br)C24CC4
CHEMBL401314 fpr2_human Human No 5.5 EC50 = 3500 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
388 4 1 3 4.0 CCC1=NC2=CC=CC=C2N1C3CCN(C3)C(=O)C4=CC5=C(N4)C=CC(=C5)OC
CHEMBL401314 fpr2_human Human No 5.5 EC50 = 3500 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
388 4 1 3 4.0 CCC1=NC2=CC=CC=C2N1C3CCN(C3)C(=O)C4=CC5=C(N4)C=CC(=C5)OC
CHEMBL3731214 fpr2_human Human No 6.5 EC50 = 352 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
402 10 2 3 3.2 CC(C)CCNC(=O)C1C2C=CC(C1C(=O)NCCCCN3CCCC3)C24CC4
CHEMBL3731214 fpr2_human Human No 6.5 EC50 = 352 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
402 10 2 3 3.2 CC(C)CCNC(=O)C1C2C=CC(C1C(=O)NCCCCN3CCCC3)C24CC4
CHEMBL3728109 fpr2_human Human No 6.5 EC50 = 354 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
414 5 2 5 2.6 C1CC12C3C=CC2C(C3C(=O)NCCF)C(=O)NC4=NC=C(S4)Br
CHEMBL3728109 fpr2_human Human No 6.5 EC50 = 354 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
414 5 2 5 2.6 C1CC12C3C=CC2C(C3C(=O)NCCF)C(=O)NC4=NC=C(S4)Br
CHEMBL3728370 fpr2_human Human No 6.4 EC50 = 365 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
388 10 2 3 2.8 CCCCNC(=O)C1C2C=CC(C1C(=O)NCCCCN3CCCC3)C24CC4
CHEMBL3728370 fpr2_human Human No 6.4 EC50 = 365 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
388 10 2 3 2.8 CCCCNC(=O)C1C2C=CC(C1C(=O)NCCCCN3CCCC3)C24CC4
CHEMBL3732612 fpr2_human Human No 5.4 EC50 = 3650 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
455 9 2 5 3.6 CC(C)(C)C1=CC(=NO1)NC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3732612 fpr2_human Human No 5.4 EC50 = 3650 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
455 9 2 5 3.6 CC(C)(C)C1=CC(=NO1)NC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3728437 fpr2_human Human No 6.4 EC50 = 367 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
494 7 3 3 2.8 C1CC12C3C=CC2C(C3C(=O)NCC4=CC=C(C=C4)CN)C(=O)NCC5=CC=C(C=C5)Br
CHEMBL3732539 fpr2_human Human No 6.4 EC50 = 367 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
521 8 2 3 4.4 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC(=C(C=C4)Br)Cl)C35CC5
CHEMBL3728437 fpr2_human Human No 6.4 EC50 = 367 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
494 7 3 3 2.8 C1CC12C3C=CC2C(C3C(=O)NCC4=CC=C(C=C4)CN)C(=O)NCC5=CC=C(C=C5)Br
CHEMBL3732539 fpr2_human Human No 6.4 EC50 = 367 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
521 8 2 3 4.4 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC(=C(C=C4)Br)Cl)C35CC5
CHEMBL3731384 fpr2_human Human No 6.4 EC50 = 369 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
385 7 2 5 1.6 CC(C)CNC(=O)C1C2C=CC(C1C(=O)NCC3=NC(=CO3)C(=O)C)C24CC4
CHEMBL3731384 fpr2_human Human No 6.4 EC50 = 369 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
385 7 2 5 1.6 CC(C)CNC(=O)C1C2C=CC(C1C(=O)NCC3=NC(=CO3)C(=O)C)C24CC4
CHEMBL3729471 fpr2_human Human No 7.4 EC50 = 37 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
518 6 2 4 4.6 C1CC12C3C=CC2C(C3CNC(=O)C4=C(ON=C4)C5=CC=CC=C5)C(=O)NC6=CC=C(C=C6)Br
CHEMBL3729471 fpr2_human Human No 7.4 EC50 = 37 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
518 6 2 4 4.6 C1CC12C3C=CC2C(C3CNC(=O)C4=C(ON=C4)C5=CC=CC=C5)C(=O)NC6=CC=C(C=C6)Br
CHEMBL212116 fpr2_human Human Yes 5.4 EC50 = 3700 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
347 3 2 4 1.1 CC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)C#N
CHEMBL212116 fpr2_human Human Yes 5.4 EC50 = 3700 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
347 3 2 4 1.1 CC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)C#N
CHEMBL3729032 fpr2_human Human No 6.4 EC50 = 373 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
488 6 3 3 3.6 CC(C)(C)C(C(=O)NC)NC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3729032 fpr2_human Human No 6.4 EC50 = 373 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
488 6 3 3 3.6 CC(C)(C)C(C(=O)NC)NC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3729805 fpr2_human Human No 7.4 EC50 = 38 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
544 8 2 4 2.5 CC(=O)N1CCN(CC1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3729805 fpr2_human Human No 7.4 EC50 = 38 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
544 8 2 4 2.5 CC(=O)N1CCN(CC1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL551589 fpr2_human Human No 5.4 EC50 = 3800 Funct
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL3730156 fpr2_human Human No 5.4 EC50 = 3800 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
554 8 2 6 4.7 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC(=C(C=C4)Br)C(F)(F)F)C35CC5
CHEMBL3590070 fprs1_mouse Mouse No 5.4 EC50 = 3800 Funct
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
525 9 4 3 6.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=CC=C5
CHEMBL551589 fpr2_human Human No 5.4 EC50 = 3800 Funct
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
442 6 1 4 3.3 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Br
CHEMBL3730156 fpr2_human Human No 5.4 EC50 = 3800 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
554 8 2 6 4.7 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC(=C(C=C4)Br)C(F)(F)F)C35CC5
CHEMBL3731785 fpr2_human Human No 6.4 EC50 = 384 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
443 7 3 6 1.2 CC(=O)C1=CSC(=N1)CNC(=O)C2C3C=CC(C2C(=O)NCC4CCNCC4)C35CC5
CHEMBL3731785 fpr2_human Human No 6.4 EC50 = 384 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
443 7 3 6 1.2 CC(=O)C1=CSC(=N1)CNC(=O)C2C3C=CC(C2C(=O)NCC4CCNCC4)C35CC5
CHEMBL3590071 fprs1_mouse Mouse No 5.4 EC50 = 3900 Funct
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
526 9 4 4 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CN=CC=C5
CHEMBL3728252 fpr2_human Human No 6.4 EC50 = 391 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
581 9 3 4 4.5 CC(C)(C)OC(=O)NCC1=CC=C(C=C1)CNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728252 fpr2_human Human No 6.4 EC50 = 391 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
581 9 3 4 4.5 CC(C)(C)OC(=O)NCC1=CC=C(C=C1)CNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3588929 fpr2_human Human No 8.4 EC50 = 4 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
474 5 4 3 3.0 C1CCN(C(=O)NC1)NC(=O)C(CC2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Br
CHEMBL3588929 fpr2_human Human No 8.4 EC50 = 4 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
474 5 4 3 3.0 C1CCN(C(=O)NC1)NC(=O)C(CC2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Br
CHEMBL3728649 fpr2_human Human No 8.4 EC50 = 4.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
515 8 2 4 3.1 CN1CCN(CC1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3731739 fpr2_human Human No 8.4 EC50 = 4.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
471 7 2 3 3.2 C1CC2C(C(C1C23CC3)C(=O)NCCCN4C=CN=C4)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3728649 fpr2_human Human No 8.4 EC50 = 4.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
515 8 2 4 3.1 CN1CCN(CC1)CCCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3731739 fpr2_human Human No 8.4 EC50 = 4.1 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
471 7 2 3 3.2 C1CC2C(C(C1C23CC3)C(=O)NCCCN4C=CN=C4)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3732493 fpr2_human Human No 8.4 EC50 = 4.2 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
504 8 3 4 3.2 CC(C)(C)OC(=O)NCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3730024 fpr2_human Human No 8.4 EC50 = 4.2 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
444 4 3 3 2.7 C1CC(CNC1)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3732493 fpr2_human Human No 8.4 EC50 = 4.2 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
504 8 3 4 3.2 CC(C)(C)OC(=O)NCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3730024 fpr2_human Human No 8.4 EC50 = 4.2 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
444 4 3 3 2.7 C1CC(CNC1)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728401 fpr2_human Human No 8.4 EC50 = 4.5 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
462 8 4 4 1.8 CC(CO)NCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3728401 fpr2_human Human No 8.4 EC50 = 4.5 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
462 8 4 4 1.8 CC(CO)NCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3728536 fpr2_human Human No 8.3 EC50 = 4.8 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
435 7 2 3 3.4 COCCCNC(=O)C1C2CCC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3730629 fpr2_human Human No 8.3 EC50 = 4.8 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
473 6 3 3 1.6 C1CC12C3C=CC2C(C3C(=O)NCCN4CCNC4=O)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3728536 fpr2_human Human No 8.3 EC50 = 4.8 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
435 7 2 3 3.4 COCCCNC(=O)C1C2CCC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3730629 fpr2_human Human No 8.3 EC50 = 4.8 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
473 6 3 3 1.6 C1CC12C3C=CC2C(C3C(=O)NCCN4CCNC4=O)C(=O)NC5=CC=C(C=C5)Br
CHEMBL3731297 fpr2_human Human No 8.3 EC50 = 4.9 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
472 7 2 3 3.4 C1CCN(C1)CCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3731297 fpr2_human Human No 8.3 EC50 = 4.9 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
472 7 2 3 3.4 C1CCN(C1)CCCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3588926 fpr2_human Human No 7.4 EC50 = 40 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
430 5 2 2 4.0 C1CCN(CC1)C(=O)C(CC2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Br
CHEMBL3732345 fpr2_human Human No 7.4 EC50 = 40 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
536 9 2 5 3.9 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=C(C(=C(C=C4)Br)F)F)C35CC5
CHEMBL3588926 fpr2_human Human No 7.4 EC50 = 40 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
430 5 2 2 4.0 C1CCN(CC1)C(=O)C(CC2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Br
CHEMBL3732345 fpr2_human Human No 7.4 EC50 = 40 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
536 9 2 5 3.9 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=C(C(=C(C=C4)Br)F)F)C35CC5
CHEMBL1289260 fpr2_human Human Yes 6.4 EC50 = 400 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
305 5 2 2 3.5 COC1=CC=C(C=C1)CCNC(=O)NC2=CC=C(C=C2)Cl
CHEMBL1289260 fpr2_human Human Yes 6.4 EC50 = 400 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
305 5 2 2 3.5 COC1=CC=C(C=C1)CCNC(=O)NC2=CC=C(C=C2)Cl
CHEMBL556625 fpr2_human Human No 5.4 EC50 = 4000 Funct
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
398 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Cl
CHEMBL556625 fpr2_human Human No 5.4 EC50 = 4000 Funct
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
398 6 1 4 3.2 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC=C(C=C3)Cl
CHEMBL3590209 fpr2_human Human Yes 5.4 EC50 = 4030 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
392 5 2 4 3.9 COC1=CC2=C(C=C1)N=C(N2)SCC(=O)NC3=CC=CC=C3Br
CHEMBL3590209 fpr2_human Human Yes 5.4 EC50 = 4030 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
392 5 2 4 3.9 COC1=CC2=C(C=C1)N=C(N2)SCC(=O)NC3=CC=CC=C3Br
CHEMBL3731221 fpr2_human Human No 7.4 EC50 = 42 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
547 9 2 3 3.7 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC=C(C=C4)I)C35CC5
CHEMBL3731221 fpr2_human Human No 7.4 EC50 = 42 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
547 9 2 3 3.7 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC=C(C=C4)I)C35CC5
CHEMBL211220 fpr2_human Human No 7.4 EC50 = 43 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
398 5 2 6 2.3 CC(C)C1=C(C(=O)N(N1C)C2=CN=CN=C2)NC(=O)NC3=CC=C(C=C3)SC
CHEMBL211220 fpr2_human Human No 7.4 EC50 = 43 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
398 5 2 6 2.3 CC(C)C1=C(C(=O)N(N1C)C2=CN=CN=C2)NC(=O)NC3=CC=C(C=C3)SC
CHEMBL3590073 fpr2_human Human No 6.4 EC50 = 430 Funct
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
526 9 4 4 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=CC=N5
CHEMBL3590073 fpr2_human Human No 6.4 EC50 = 430 Funct
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
526 9 4 4 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=CC=N5
CHEMBL2391258 fpr2_human Human No 5.4 EC50 = 4300 Funct
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
504 7 1 4 4.9 COC1=CC=CC(=C1)CC2=CC(=NN(C2=O)CC(=O)NC3=CC=C(C=C3)Br)C4=CC=CC=C4
CHEMBL380389 fpr2_human Human No 7.4 EC50 = 44 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
469 4 2 7 4.7 CC(C)C1=C(C(=O)N(N1C)C2=CC3=CC=CC=C3N=C2)NC(=O)NC4=CC=C(C=C4)C(F)(F)F
CHEMBL379761 fpr2_human Human Yes 7.4 EC50 = 44 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
385 4 2 3 4.1 CC(C)C1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Cl
CHEMBL3727690 fpr2_human Human No 7.4 EC50 = 44 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
426 6 2 5 2.1 COCCNC(=O)C1C2C=CC(C1C(=O)NC3=NC=C(S3)Br)C24CC4
CHEMBL379761 fpr2_human Human Yes 7.4 EC50 = 44 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
385 4 2 3 4.1 CC(C)C1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Cl
CHEMBL380389 fpr2_human Human No 7.4 EC50 = 44 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
469 4 2 7 4.7 CC(C)C1=C(C(=O)N(N1C)C2=CC3=CC=CC=C3N=C2)NC(=O)NC4=CC=C(C=C4)C(F)(F)F
CHEMBL379761 fpr2_human Human Yes 7.4 EC50 = 44 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
385 4 2 3 4.1 CC(C)C1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Cl
CHEMBL3727690 fpr2_human Human No 7.4 EC50 = 44 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
426 6 2 5 2.1 COCCNC(=O)C1C2C=CC(C1C(=O)NC3=NC=C(S3)Br)C24CC4
CHEMBL379761 fpr2_human Human Yes 7.4 EC50 = 44 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
385 4 2 3 4.1 CC(C)C1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Cl
CHEMBL3731677 fpr2_human Human No 5.4 EC50 = 4420 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
479 8 2 5 3.9 CC1=NSC2=C1C=CC(=C2)NC(=O)C3C4C=CC(C3C(=O)NCCCCN5CCCC5)C46CC6
CHEMBL3731677 fpr2_human Human No 5.4 EC50 = 4420 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
479 8 2 5 3.9 CC1=NSC2=C1C=CC(=C2)NC(=O)C3C4C=CC(C3C(=O)NCCCCN5CCCC5)C46CC6
CHEMBL3729184 fpr2_human Human No 7.4 EC50 = 45 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
487 6 3 5 2.6 C1CC12C3C=CC2C(C3C(=O)NCC4=CC=C(C=C4)CN)C(=O)NC5=NC=C(S5)Br
CHEMBL3729184 fpr2_human Human No 7.4 EC50 = 45 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
487 6 3 5 2.6 C1CC12C3C=CC2C(C3C(=O)NCC4=CC=C(C=C4)CN)C(=O)NC5=NC=C(S5)Br
CHEMBL3590073 fpr2_human Human No 6.4 EC50 = 450 Funct
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
526 9 4 4 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=CC=N5
CHEMBL3590073 fpr2_human Human No 6.4 EC50 = 450 Funct
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
526 9 4 4 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=CC=N5
CHEMBL556485 fpr2_human Human No 5.4 EC50 = 4500 Funct
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
407 6 1 6 2.4 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC4=C(C=C3)OCO4
CHEMBL556485 fpr2_human Human No 5.4 EC50 = 4500 Funct
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
407 6 1 6 2.4 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC4=C(C=C3)OCO4
CHEMBL556485 fpr2_human Human No 5.4 EC50 = 4500 Funct
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
407 6 1 6 2.4 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC4=C(C=C3)OCO4
CHEMBL556485 fpr2_human Human No 5.4 EC50 = 4500 Funct
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
407 6 1 6 2.4 CC1=NN(C(=O)C(=C1)CC2=CC(=CC=C2)OC)CC(=O)NC3=CC4=C(C=C3)OCO4
CHEMBL3728190 fpr2_human Human No 7.3 EC50 = 46 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
436 9 2 3 3.4 CC1=CC=C(C=C1)CNC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3730955 fpr2_human Human No 7.3 EC50 = 46 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
536 9 2 5 3.9 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC(=C(C(=C4)F)Br)F)C35CC5
CHEMBL3728190 fpr2_human Human No 7.3 EC50 = 46 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
436 9 2 3 3.4 CC1=CC=C(C=C1)CNC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3730955 fpr2_human Human No 7.3 EC50 = 46 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
536 9 2 5 3.9 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC(=C(C(=C4)F)Br)F)C35CC5
CHEMBL3727588 fpr2_human Human No 6.3 EC50 = 463 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
429 8 2 5 2.8 CC1=CN=C(S1)NC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3731359 fpr2_human Human No 6.3 EC50 = 463 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
518 7 3 2 4.9 C1CC12C3C=CC2C(C3CNC(=O)CCC4=CC5=CC=CC=C5N4)C(=O)NC6=CC=C(C=C6)Br
CHEMBL3727588 fpr2_human Human No 6.3 EC50 = 463 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
429 8 2 5 2.8 CC1=CN=C(S1)NC(=O)C2C3C=CC(C2C(=O)NCCCCN4CCCC4)C35CC5
CHEMBL3731359 fpr2_human Human No 6.3 EC50 = 463 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
518 7 3 2 4.9 C1CC12C3C=CC2C(C3CNC(=O)CCC4=CC5=CC=CC=C5N4)C(=O)NC6=CC=C(C=C6)Br
CHEMBL3728194 fpr2_human Human No 6.3 EC50 = 467 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
542 10 3 6 4.3 CC(C)(C)OC(=O)NCCCCNC(=O)C1C2CCC(C1C(=O)NC3=NC=C(S3)Br)C24CC4
CHEMBL3728194 fpr2_human Human No 6.3 EC50 = 467 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
542 10 3 6 4.3 CC(C)(C)OC(=O)NCCCCNC(=O)C1C2CCC(C1C(=O)NC3=NC=C(S3)Br)C24CC4
CHEMBL3729722 fpr2_human Human No 7.3 EC50 = 47 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
500 9 2 3 3.7 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC=C(C=C4)Br)C35CC5
CHEMBL3731426 fpr2_human Human No 7.3 EC50 = 47 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
500 8 2 3 2.7 C1CC(=O)N(C1)CCCC(=O)NCC2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3731426 fpr2_human Human No 7.3 EC50 = 47 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
500 8 2 3 2.7 C1CC(=O)N(C1)CCCC(=O)NCC2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3590217 fpr2_human Human No 6.3 EC50 = 470 Funct
Agonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assayAgonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assay
432 8 2 5 5.5 CCCCOC1=CC=C(C=C1)C(=O)NN2CC3=CC=CC=C3NC2C4=CC=C(C=C4)OC
CHEMBL3590217 fpr2_human Human No 6.3 EC50 = 470 Funct
Agonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assayAgonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assay
432 8 2 5 5.5 CCCCOC1=CC=C(C=C1)C(=O)NN2CC3=CC=CC=C3NC2C4=CC=C(C=C4)OC
CHEMBL1290698 fpr2_human Human Yes 5.3 EC50 = 4700 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
373 7 2 6 3.1 COC1=CC2=C(C=C1)N=C(N2)SCC(=O)NC3=CC(=C(C=C3)OC)OC
CHEMBL1290698 fpr2_human Human Yes 5.3 EC50 = 4700 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
373 7 2 6 3.1 COC1=CC2=C(C=C1)N=C(N2)SCC(=O)NC3=CC(=C(C=C3)OC)OC
CHEMBL3732252 fpr2_human Human No 5.3 EC50 = 4720 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
474 9 2 4 3.7 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=C(C(=CC=C4)Cl)F)C35CC5
CHEMBL3732252 fpr2_human Human No 5.3 EC50 = 4720 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
474 9 2 4 3.7 C1CCN(C1)CCCCNC(=O)C2C3C=CC(C2C(=O)NCC4=C(C(=CC=C4)Cl)F)C35CC5
CHEMBL3731092 fpr2_human Human No 6.3 EC50 = 477 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
516 6 2 4 3.3 CC(C)(C)OC(=O)N1CC(C1)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728337 fpr2_human Human No 6.3 EC50 = 477 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
486 9 2 7 1.1 CC(=O)C1=CSC(=N1)CNC(=O)C2C3C=CC(C2C(=O)NCCCN4CCN(CC4)C)C35CC5
CHEMBL3731092 fpr2_human Human No 6.3 EC50 = 477 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
516 6 2 4 3.3 CC(C)(C)OC(=O)N1CC(C1)NC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3728337 fpr2_human Human No 6.3 EC50 = 477 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
486 9 2 7 1.1 CC(=O)C1=CSC(=N1)CNC(=O)C2C3C=CC(C2C(=O)NCCCN4CCN(CC4)C)C35CC5
CHEMBL378707 fpr2_human Human Yes 5.3 EC50 = 4850 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
340 3 2 4 1.5 CC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)F
CHEMBL378707 fpr2_human Human Yes 5.3 EC50 = 4850 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
340 3 2 4 1.5 CC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)F
CHEMBL3730506 fpr2_human Human No 7.3 EC50 = 49 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
508 7 2 6 2.4 CN1CCN(CC1)CCCNC(=O)C2C3C=CC(C2C(=O)NC4=NC=C(S4)Br)C35CC5
CHEMBL3730671 fpr2_human Human No 7.3 EC50 = 49 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
486 8 2 3 3.3 C1CCN(C1)CCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC=C(C=C4)Br)C35CC5
CHEMBL3730506 fpr2_human Human No 7.3 EC50 = 49 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
508 7 2 6 2.4 CN1CCN(CC1)CCCNC(=O)C2C3C=CC(C2C(=O)NC4=NC=C(S4)Br)C35CC5
CHEMBL3730671 fpr2_human Human No 7.3 EC50 = 49 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
486 8 2 3 3.3 C1CCN(C1)CCCNC(=O)C2C3C=CC(C2C(=O)NCC4=CC=C(C=C4)Br)C35CC5
CHEMBL210298 fpr2_human Human Yes 6.3 EC50 = 490 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
357 3 2 3 2.0 CC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Cl
CHEMBL3590074 fpr2_human Human No 6.3 EC50 = 490 Funct
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
526 9 4 4 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=CC=N5
CHEMBL210298 fpr2_human Human Yes 6.3 EC50 = 490 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
357 3 2 3 2.0 CC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Cl
CHEMBL3590074 fpr2_human Human No 6.3 EC50 = 490 Funct
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
526 9 4 4 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=CC=CC=N5
CHEMBL3589946 fprs1_mouse Mouse No 5.3 EC50 = 4900 Funct
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
556 10 4 5 5.2 COC1=CC=C(C=C1)NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC4(CCCCC4)C5=NC=C(C=C5)OC
CHEMBL3731396 fpr2_human Human No 8.3 EC50 = 5 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
419 6 2 3 2.4 COCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3731396 fpr2_human Human No 8.3 EC50 = 5 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
419 6 2 3 2.4 COCCNC(=O)C1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3731308 fpr2_human Human No 8.3 EC50 = 5.4 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
478 8 2 6 4.6 C1CCN(C1)CCCCNC(=O)C2C3CCC(C2C(=O)NC4=CC=C(C=C4)C(F)(F)F)C35CC5
CHEMBL3732803 fpr2_human Human No 8.3 EC50 = 5.4 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
519 7 3 3 4.4 C1CC12C3C=CC2C(C3C(=O)NCCCC4=NC5=CC=CC=C5N4)C(=O)NC6=CC=C(C=C6)Br
CHEMBL3731308 fpr2_human Human No 8.3 EC50 = 5.4 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
478 8 2 6 4.6 C1CCN(C1)CCCCNC(=O)C2C3CCC(C2C(=O)NC4=CC=C(C=C4)C(F)(F)F)C35CC5
CHEMBL3732803 fpr2_human Human No 8.3 EC50 = 5.4 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
519 7 3 3 4.4 C1CC12C3C=CC2C(C3C(=O)NCCCC4=NC5=CC=CC=C5N4)C(=O)NC6=CC=C(C=C6)Br
CHEMBL3730960 fpr2_human Human No 8.2 EC50 = 5.7 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
465 5 3 5 2.5 C1CNCCC1CNC(=O)C2C3C=CC(C2C(=O)NC4=NC=C(S4)Br)C35CC5
CHEMBL3730960 fpr2_human Human No 8.2 EC50 = 5.7 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
465 5 3 5 2.5 C1CNCCC1CNC(=O)C2C3C=CC(C2C(=O)NC4=NC=C(S4)Br)C35CC5
CHEMBL3729542 fpr2_human Human No 8.2 EC50 = 5.8 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
472 6 2 3 3.5 CN1CCCC1CCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3729542 fpr2_human Human No 8.2 EC50 = 5.8 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
472 6 2 3 3.5 CN1CCCC1CCNC(=O)C2C3C=CC(C2C(=O)NC4=CC=C(C=C4)Br)C35CC5
CHEMBL3731817 fpr2_human Human No 8.2 EC50 = 5.9 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
433 6 3 4 0.6 C1CC12C3C=CC2C(C3C(=O)NCCC(=O)N)C(=O)NC4=CN=C(C=C4)Br
CHEMBL3731817 fpr2_human Human No 8.2 EC50 = 5.9 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
433 6 3 4 0.6 C1CC12C3C=CC2C(C3C(=O)NCCC(=O)N)C(=O)NC4=CN=C(C=C4)Br
CHEMBL3588927 fpr2_human Human Yes 7.3 EC50 = 50 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
386 5 2 2 3.9 C1CCN(CC1)C(=O)C(CC2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Cl
CHEMBL3588927 fpr2_human Human Yes 7.3 EC50 = 50 Funct
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
386 5 2 2 3.9 C1CCN(CC1)C(=O)C(CC2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Cl
CHEMBL3728603 fpr2_human Human No 6.3 EC50 = 505 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
417 6 2 2 3.6 CCCC(=O)NCC1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL3728603 fpr2_human Human No 6.3 EC50 = 505 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
417 6 2 2 3.6 CCCC(=O)NCC1C2C=CC(C1C(=O)NC3=CC=C(C=C3)Br)C24CC4
CHEMBL250143 fpr2_human Human No 5.3 EC50 = 5100 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
374 3 1 3 3.5 COC1=CC2=C(C=C1)NC(=C2)C(=O)N3CCC(CC3)N4C=NC5=CC=CC=C54
CHEMBL250143 fpr2_human Human No 5.3 EC50 = 5100 Funct
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
374 3 1 3 3.5 COC1=CC2=C(C=C1)NC(=C2)C(=O)N3CCC(CC3)N4C=NC5=CC=CC=C54
CHEMBL377163 fpr2_human Human No 5.3 EC50 = 5130 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
406 5 2 6 2.9 CC(C)C1=C(C(=O)N(N1C)C2=NCCS2)NC(=O)NC3=CC=C(C=C3)SC
CHEMBL377163 fpr2_human Human No 5.3 EC50 = 5130 Funct
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
406 5 2 6 2.9 CC(C)C1=C(C(=O)N(N1C)C2=NCCS2)NC(=O)NC3=CC=C(C=C3)SC
CHEMBL3731200 fpr2_human Human No 6.3 EC50 = 516 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
384 7 3 5 1.3 COC1=CC=C(C=C1)NC(=O)C2C3C=CC(C2C(=O)NCCC(=O)O)C34CC4
CHEMBL3731200 fpr2_human Human No 6.3 EC50 = 516 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
384 7 3 5 1.3 COC1=CC=C(C=C1)NC(=O)C2C3C=CC(C2C(=O)NCCC(=O)O)C34CC4
CHEMBL3728159 fpr2_human Human No 6.3 EC50 = 519 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
556 11 3 6 4.6 CC(C)(C)OC(=O)NCCCCCNC(=O)C1C2CCC(C1C(=O)NC3=NC=C(S3)Br)C24CC4
CHEMBL3728159 fpr2_human Human No 6.3 EC50 = 519 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
556 11 3 6 4.6 CC(C)(C)OC(=O)NCCCCCNC(=O)C1C2CCC(C1C(=O)NC3=NC=C(S3)Br)C24CC4
CHEMBL3730697 fpr2_human Human No 7.3 EC50 = 52 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
464 8 3 4 2.3 C1CC12C3C=CC2C(C3C(=O)NCCCCN)C(=O)NCC4=C(C=C(C=C4)Br)F
CHEMBL3731492 fpr2_human Human No 7.3 EC50 = 52 Funct
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
418 11 2 5 1.3 COC(=O)CCNC(=O)C1C2C=CC(C1C(=O)NCCCCN3CCCC3)C24CC4
CHEMBL3730697 fpr2_human Human No