GPCRdb

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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

[D-Arg¹,D-Phe⁵,D-Trp^7,9,Leu¹¹]substance P	1321	None	0	Human	Binding	pKd	=	-	7.35	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/12907757
[des-octanoyl]ghrelin	1391	None	0	Rat	Binding	pKi	=	-	7.90	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/11314756
[des-octanoyl]ghrelin	1391	None	0	Rat	Binding	pKi	=	-	7.90	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/14763915
amiodarone	398	None	47	Human	Binding	AC50	=	7021.40	5.15	-	40	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645.0	11	0	4	6.94	CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1	https://dx.doi.org/10.1038/s41467-023-40064-9
APRINDINE	15289	None	20	Human	Binding	AC50	=	15000.00	4.82	-	12	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	322.2	8	0	2	4.39	CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1	https://dx.doi.org/10.1038/s41467-023-40064-9
aripiprazole	470	None	70	Human	Binding	AC50	=	12041.60	4.92	-	60	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	447.1	7	1	4	4.86	O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2N1	https://dx.doi.org/10.1038/s41467-023-40064-9
ASENAPINE	107587	None	16	Human	Binding	AC50	=	23999.90	4.62	-	54	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	285.1	0	0	2	4.26	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	https://dx.doi.org/10.1038/s41467-023-40064-9
astemizole	505	None	55	Human	Binding	AC50	=	8199.90	5.09	-	48	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458.2	8	1	5	5.35	COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1	https://dx.doi.org/10.1038/s41467-023-40064-9
ATAZANAVIR	10423	None	49	Human	Binding	AC50	=	10600.10	4.97	-	4	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	704.4	14	5	9	4.21	COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C	https://dx.doi.org/10.1038/s41467-023-40064-9
ATRACURIUM	26472	None	27	Human	Binding	AC50	=	11200.10	4.95	-	6	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	928.5	24	0	12	8.07	COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC	https://dx.doi.org/10.1038/s41467-023-40064-9
azelastine	559	None	45	Human	Binding	AC50	=	14000.10	4.85	-	25	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381.2	3	0	4	4.30	CN1CCCC(n2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)CC1	https://dx.doi.org/10.1038/s41467-023-40064-9
BAZEDOXIFENE	178724	None	43	Human	Binding	AC50	=	1100.00	5.96	-	19	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	470.3	7	2	5	6.33	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	https://dx.doi.org/10.1038/s41467-023-40064-9
BENFLUOREX	154946	None	18	Human	Binding	AC50	=	28000.10	4.55	-	15	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	351.1	7	1	3	4.08	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	https://dx.doi.org/10.1038/s41467-023-40064-9
BENIDIPINE	77126	None	16	Human	Binding	AC50	=	25999.80	4.58	-	11	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	505.2	7	1	8	4.21	COC(=O)C1=C(C)NC(C)=C(C(=O)OC2CCCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1	https://dx.doi.org/10.1038/s41467-023-40064-9
benperidol	596	None	33	Human	Binding	AC50	=	17000.00	4.77	-	24	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381.2	6	1	4	3.77	O=C(CCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	https://dx.doi.org/10.1038/s41467-023-40064-9
BENZETHONIUM	11852	None	18	Human	Binding	AC50	=	6400.00	5.19	-	35	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412.3	11	0	2	6.07	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	https://dx.doi.org/10.1038/s41467-023-40064-9
BEPRIDIL	4301	None	35	Human	Binding	AC50	=	22137.50	4.66	-	22	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	366.3	10	0	3	4.83	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	https://dx.doi.org/10.1038/s41467-023-40064-9
BICALUTAMIDE	158486	None	71	Human	Binding	AC50	=	2200.00	5.66	-	2	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	430.1	5	2	5	2.88	CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1	https://dx.doi.org/10.1038/s41467-023-40064-9
BIM 28163	657	None	0	Human	Binding	pKi	=	-	8.09	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/15339248
BOPINDOLOL	121354	None	36	Human	Binding	AC50	=	16000.00	4.80	-	12	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	380.2	7	2	4	4.47	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	https://dx.doi.org/10.1038/s41467-023-40064-9

Showing 1 to 20 of 1,648 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)