Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
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Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
44570962 | 183963 | None | 0 | Human | Functional | pEC50 | = | 10.3 | 10.3 | - | 1 | ChEMBL | 435 | 4 | 1 | 5 | 2.5 | Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL480821 | 183963 | None | 0 | Human | Functional | pEC50 | = | 10.3 | 10.3 | - | 1 | ChEMBL | 435 | 4 | 1 | 5 | 2.5 | Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1 | 10.1016/j.bmcl.2008.12.042 | |||
145950336 | 162922 | None | 0 | Human | Functional | pEC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 430 | 4 | 3 | 3 | 3.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4172656 | 162922 | None | 0 | Human | Functional | pEC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 430 | 4 | 3 | 3 | 3.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
156016416 | 177762 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 571 | 6 | 3 | 5 | 3.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4641513 | 177762 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 571 | 6 | 3 | 5 | 3.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
16752684 | 94552 | None | 1 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 484 | 5 | 1 | 7 | 3.8 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
CHEMBL251572 | 94552 | None | 1 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 484 | 5 | 1 | 7 | 3.8 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
156014430 | 177328 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 523 | 7 | 3 | 5 | 2.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4635542 | 177328 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 523 | 7 | 3 | 5 | 2.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
156016416 | 177762 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 571 | 6 | 3 | 5 | 3.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4641513 | 177762 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 571 | 6 | 3 | 5 | 3.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
16752684 | 94552 | None | 1 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 484 | 5 | 1 | 7 | 3.8 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL251572 | 94552 | None | 1 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 484 | 5 | 1 | 7 | 3.8 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2 | 10.1016/j.bmcl.2008.12.042 | |||
44570963 | 183986 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 435 | 4 | 1 | 5 | 2.5 | Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2F)o1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL481013 | 183986 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 435 | 4 | 1 | 5 | 2.5 | Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2F)o1 | 10.1016/j.bmcl.2008.12.042 | |||
156014430 | 177328 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 523 | 7 | 3 | 5 | 2.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4635542 | 177328 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 523 | 7 | 3 | 5 | 2.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44444563 | 155045 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 478 | 5 | 1 | 6 | 3.7 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)cc1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
CHEMBL401134 | 155045 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 478 | 5 | 1 | 6 | 3.7 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)cc1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
156011926 | 177505 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 557 | 6 | 4 | 5 | 2.8 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4638297 | 177505 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 557 | 6 | 4 | 5 | 2.8 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44571002 | 191207 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 437 | 4 | 2 | 6 | 1.1 | Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H](O)[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL518774 | 191207 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 437 | 4 | 2 | 6 | 1.1 | Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H](O)[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1 | 10.1016/j.bmcl.2008.12.042 | |||
44449987 | 95946 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 493 | 16 | 4 | 10 | 0.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCSCCO | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL259166 | 95946 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 493 | 16 | 4 | 10 | 0.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCSCCO | 10.1016/j.bmcl.2008.03.059 | |||
25010378 | 159492 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 525 | 16 | 4 | 11 | -0.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(=O)(=O)CCO | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL410074 | 159492 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 525 | 16 | 4 | 11 | -0.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(=O)(=O)CCO | 10.1016/j.bmcl.2008.03.059 | |||
44449955 | 159506 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 509 | 14 | 4 | 9 | 1.6 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(O)c1 | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL410085 | 159506 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 509 | 14 | 4 | 9 | 1.6 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(O)c1 | 10.1016/j.bmcl.2008.03.059 | |||
156011926 | 177505 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 557 | 6 | 4 | 5 | 2.8 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4638297 | 177505 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 557 | 6 | 4 | 5 | 2.8 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
156017918 | 177911 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 591 | 7 | 3 | 7 | 2.9 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4643530 | 177911 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 591 | 7 | 3 | 7 | 2.9 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1 | 10.1021/acs.jmedchem.0c00828 | |||
156015100 | 177677 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 523 | 6 | 3 | 5 | 2.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4640507 | 177677 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 523 | 6 | 3 | 5 | 2.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
156017918 | 177911 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 591 | 7 | 3 | 7 | 2.9 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4643530 | 177911 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 591 | 7 | 3 | 7 | 2.9 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1 | 10.1021/acs.jmedchem.0c00828 | |||
44570960 | 184094 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 417 | 4 | 1 | 5 | 2.4 | Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL481796 | 184094 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 417 | 4 | 1 | 5 | 2.4 | Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1 | 10.1016/j.bmcl.2008.12.042 | |||
24894012 | 176902 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 497 | 14 | 4 | 9 | 1.6 | CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.05.100 | |||
CHEMBL460680 | 176902 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 497 | 14 | 4 | 9 | 1.6 | CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.05.100 | |||
156015100 | 177677 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 523 | 6 | 3 | 5 | 2.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4640507 | 177677 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 523 | 6 | 3 | 5 | 2.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44437979 | 10329 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 655 | 12 | 5 | 5 | 4.1 | NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1162065 | 10329 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 655 | 12 | 5 | 5 | 4.1 | NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1 | 10.1016/j.bmc.2007.01.057 | |||
44437979 | 10329 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 655 | 12 | 5 | 5 | 4.1 | NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1162065 | 10329 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 655 | 12 | 5 | 5 | 4.1 | NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1 | 10.1016/j.bmc.2007.01.057 | |||
44454303 | 97622 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 479 | 12 | 3 | 10 | 2.0 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL270666 | 97622 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 479 | 12 | 3 | 10 | 2.0 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O | 10.1016/j.bmcl.2008.01.100 | |||
156020725 | 178210 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 509 | 6 | 4 | 5 | 1.8 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4647963 | 178210 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 509 | 6 | 4 | 5 | 1.8 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44570764 | 184155 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 481 | 4 | 1 | 4 | 3.8 | N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(Cl)ccc3Cl)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL482220 | 184155 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 481 | 4 | 1 | 4 | 3.8 | N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(Cl)ccc3Cl)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
24803512 | 89041 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 489 | 6 | 2 | 6 | 4.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1Cl | 10.6019/CHEMBL2364335 | |||
CHEMBL2364468 | 89041 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 489 | 6 | 2 | 6 | 4.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1Cl | 10.6019/CHEMBL2364335 | |||
156020725 | 178210 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 509 | 6 | 4 | 5 | 1.8 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4647963 | 178210 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 509 | 6 | 4 | 5 | 1.8 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
9917957 | 109774 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 683 | 14 | 4 | 5 | 4.3 | NC(=O)CN(CCc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1 | 10.1021/jm970342o | |||
CHEMBL322912 | 109774 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 683 | 14 | 4 | 5 | 4.3 | NC(=O)CN(CCc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1 | 10.1021/jm970342o | |||
44447855 | 195238 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 539 | 15 | 4 | 10 | 2.0 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1ccccc1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
CHEMBL539929 | 195238 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 539 | 15 | 4 | 10 | 2.0 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1ccccc1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
178024 | 1971 | None | 27 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -1 | 3 | ChEMBL | 528 | 8 | 2 | 6 | 1.8 | O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C | 10.1021/acs.jmedchem.8b00322 | |||
5867 | 1971 | None | 27 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -1 | 3 | ChEMBL | 528 | 8 | 2 | 6 | 1.8 | O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL13817 | 1971 | None | 27 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -1 | 3 | ChEMBL | 528 | 8 | 2 | 6 | 1.8 | O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C | 10.1021/acs.jmedchem.8b00322 | |||
156013414 | 177577 | None | 7 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 1905 | 4 | ChEMBL | 557 | 7 | 3 | 7 | 2.3 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4639111 | 177577 | None | 7 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 1905 | 4 | ChEMBL | 557 | 7 | 3 | 7 | 2.3 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1 | 10.1021/acs.jmedchem.0c00828 | |||
156013297 | 177589 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 523 | 6 | 3 | 5 | 2.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4639229 | 177589 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 523 | 6 | 3 | 5 | 2.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44452749 | 96268 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 499 | 7 | 2 | 6 | 4.5 | COc1ccc(F)c(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL260819 | 96268 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 499 | 7 | 2 | 6 | 4.5 | COc1ccc(F)c(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1 | 10.1016/j.bmcl.2007.12.021 | |||
44570765 | 191549 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 421 | 4 | 1 | 5 | 2.1 | Cc1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL519301 | 191549 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 421 | 4 | 1 | 5 | 2.1 | Cc1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1 | 10.1016/j.bmcl.2008.12.042 | |||
59007047 | 88999 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 485 | 6 | 2 | 6 | 5.0 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1C | 10.6019/CHEMBL2364335 | |||
CHEMBL2364427 | 88999 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 485 | 6 | 2 | 6 | 5.0 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1C | 10.6019/CHEMBL2364335 | |||
178024 | 1971 | None | 27 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -1 | 3 | ChEMBL | 528 | 8 | 2 | 6 | 1.8 | O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C | 10.1021/acs.jmedchem.8b00322 | |||
5867 | 1971 | None | 27 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -1 | 3 | ChEMBL | 528 | 8 | 2 | 6 | 1.8 | O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL13817 | 1971 | None | 27 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -1 | 3 | ChEMBL | 528 | 8 | 2 | 6 | 1.8 | O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C | 10.1021/acs.jmedchem.8b00322 | |||
25022640 | 97854 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 464 | 12 | 2 | 10 | 1.7 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1 | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL271876 | 97854 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 464 | 12 | 2 | 10 | 1.7 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1 | 10.1016/j.bmcl.2008.01.100 | |||
44454337 | 155693 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 463 | 12 | 2 | 9 | 2.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1 | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL404545 | 155693 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 463 | 12 | 2 | 9 | 2.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1 | 10.1016/j.bmcl.2008.01.100 | |||
44447839 | 95044 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 499 | 14 | 4 | 10 | 0.6 | CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
CHEMBL254765 | 95044 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 499 | 14 | 4 | 10 | 0.6 | CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
156013414 | 177577 | None | 7 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 1905 | 4 | ChEMBL | 557 | 7 | 3 | 7 | 2.3 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4639111 | 177577 | None | 7 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 1905 | 4 | ChEMBL | 557 | 7 | 3 | 7 | 2.3 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1 | 10.1021/acs.jmedchem.0c00828 | |||
156013297 | 177589 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 523 | 6 | 3 | 5 | 2.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4639229 | 177589 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 523 | 6 | 3 | 5 | 2.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44447857 | 166972 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 497 | 14 | 4 | 10 | 0.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1Cl)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
CHEMBL428592 | 166972 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 497 | 14 | 4 | 10 | 0.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1Cl)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
156019724 | 178096 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 523 | 7 | 3 | 5 | 2.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4646219 | 178096 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 523 | 7 | 3 | 5 | 2.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
22888474 | 63484 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 525 | 9 | 1 | 6 | 5.6 | COc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1 | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL179823 | 63484 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 525 | 9 | 1 | 6 | 5.6 | COc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1 | 10.1016/j.bmcl.2005.02.040 | |||
11306502 | 63663 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 495 | 8 | 1 | 5 | 5.5 | CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL180094 | 63663 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 495 | 8 | 1 | 5 | 5.5 | CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
11306502 | 63663 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 495 | 8 | 1 | 5 | 5.5 | CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL180094 | 63663 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 495 | 8 | 1 | 5 | 5.5 | CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
11306502 | 63663 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 495 | 8 | 1 | 5 | 5.5 | CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL180094 | 63663 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 495 | 8 | 1 | 5 | 5.5 | CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
22888476 | 122884 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 525 | 9 | 1 | 6 | 5.6 | COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1 | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL360547 | 122884 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 525 | 9 | 1 | 6 | 5.6 | COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1 | 10.1016/j.bmcl.2005.02.040 | |||
22888476 | 122884 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 525 | 9 | 1 | 6 | 5.6 | COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1 | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL360547 | 122884 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 525 | 9 | 1 | 6 | 5.6 | COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1 | 10.1016/j.bmcl.2005.02.040 | |||
44454117 | 155646 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 459 | 11 | 2 | 8 | 3.0 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL404336 | 155646 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 459 | 11 | 2 | 8 | 3.0 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N | 10.1016/j.bmcl.2008.01.100 | |||
44444559 | 94489 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 451 | 4 | 1 | 5 | 3.8 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
CHEMBL251169 | 94489 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 451 | 4 | 1 | 5 | 3.8 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
156011750 | 177395 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 571 | 7 | 3 | 7 | 2.6 | Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4636502 | 177395 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 571 | 7 | 3 | 7 | 2.6 | Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
156019724 | 178096 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 523 | 7 | 3 | 5 | 2.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4646219 | 178096 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 523 | 7 | 3 | 5 | 2.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44453123 | 98039 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 503 | 6 | 2 | 5 | 5.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(Cl)ccc2F)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL272753 | 98039 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 503 | 6 | 2 | 5 | 5.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(Cl)ccc2F)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
44570966 | 183675 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 437 | 4 | 2 | 6 | 1.1 | Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL480037 | 183675 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 437 | 4 | 2 | 6 | 1.1 | Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1 | 10.1016/j.bmcl.2008.12.042 | |||
59007062 | 89001 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 489 | 6 | 2 | 6 | 4.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1F | 10.6019/CHEMBL2364335 | |||
CHEMBL2364429 | 89001 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 489 | 6 | 2 | 6 | 4.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1F | 10.6019/CHEMBL2364335 | |||
24803514 | 89046 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 475 | 6 | 2 | 6 | 4.6 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1Cl | 10.6019/CHEMBL2364335 | |||
CHEMBL2364472 | 89046 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 475 | 6 | 2 | 6 | 4.6 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1Cl | 10.6019/CHEMBL2364335 | |||
44447852 | 155652 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 477 | 14 | 4 | 10 | 0.6 | Cc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
CHEMBL404354 | 155652 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 477 | 14 | 4 | 10 | 0.6 | Cc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
156011750 | 177395 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 571 | 7 | 3 | 7 | 2.6 | Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4636502 | 177395 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 571 | 7 | 3 | 7 | 2.6 | Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
172452165 | 195816 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 2479 | 79 | 38 | 37 | -13.1 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CCCCNC(=O)C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1039/d3md00441d | |||
CHEMBL5411243 | 195816 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 2479 | 79 | 38 | 37 | -13.1 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CCCCNC(=O)C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1039/d3md00441d | |||
44450016 | 160654 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 489 | 17 | 4 | 9 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCCO | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL411259 | 160654 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 489 | 17 | 4 | 9 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCCO | 10.1016/j.bmcl.2008.03.059 | |||
44454367 | 95314 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 481 | 12 | 2 | 9 | 2.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL256235 | 95314 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 481 | 12 | 2 | 9 | 2.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F | 10.1016/j.bmcl.2008.01.100 | |||
22867441 | 10317 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 474 | 5 | 4 | 4 | 2.9 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161835 | 10317 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 474 | 5 | 4 | 4 | 2.9 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
16114096 | 79191 | None | 1 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 631 | 12 | 4 | 7 | 5.5 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1 | 10.1021/jm0704550 | |||
CHEMBL2113324 | 79191 | None | 1 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 631 | 12 | 4 | 7 | 5.5 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1 | 10.1021/jm0704550 | |||
22867441 | 10317 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 474 | 5 | 4 | 4 | 2.9 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161835 | 10317 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 474 | 5 | 4 | 4 | 2.9 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
44447841 | 155168 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 531 | 14 | 4 | 10 | 1.6 | CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1Cl)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
CHEMBL401827 | 155168 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 531 | 14 | 4 | 10 | 1.6 | CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1Cl)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
69195371 | 88925 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 472 | 6 | 2 | 7 | 4.1 | COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364354 | 88925 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 472 | 6 | 2 | 7 | 4.1 | COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
44450101 | 159554 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 495 | 13 | 4 | 9 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCc1cccc(O)c1 | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL410135 | 159554 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 495 | 13 | 4 | 9 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCc1cccc(O)c1 | 10.1016/j.bmcl.2008.03.059 | |||
44391039 | 131856 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 540 | 9 | 1 | 7 | 5.5 | CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc([N+](=O)[O-])c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL369329 | 131856 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 540 | 9 | 1 | 7 | 5.5 | CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc([N+](=O)[O-])c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
44449988 | 161195 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 477 | 16 | 4 | 10 | -0.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCOCCO | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL411697 | 161195 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 477 | 16 | 4 | 10 | -0.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCOCCO | 10.1016/j.bmcl.2008.03.059 | |||
44447843 | 95073 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 531 | 14 | 4 | 10 | 1.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1C(F)(F)F)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
CHEMBL254973 | 95073 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 531 | 14 | 4 | 10 | 1.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1C(F)(F)F)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
10280020 | 63112 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 529 | 8 | 1 | 5 | 6.2 | CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(Cl)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL178900 | 63112 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 529 | 8 | 1 | 5 | 6.2 | CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(Cl)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
156021297 | 178194 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 511 | 8 | 3 | 5 | 2.0 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4647797 | 178194 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 511 | 8 | 3 | 5 | 2.0 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44444571 | 94032 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 498 | 5 | 1 | 7 | 4.1 | COc1cc2c(cc1N1C[C@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
CHEMBL248544 | 94032 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 498 | 5 | 1 | 7 | 4.1 | COc1cc2c(cc1N1C[C@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
10553921 | 104616 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 517 | 9 | 4 | 4 | 2.9 | CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL310457 | 104616 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 517 | 9 | 4 | 4 | 2.9 | CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1 | 10.1016/j.bmc.2007.01.057 | |||
10345516 | 139362 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 491 | 11 | 1 | 4 | 4.9 | CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL379074 | 139362 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 491 | 11 | 1 | 4 | 4.9 | CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1 | 10.1016/j.bmc.2007.01.057 | |||
156012122 | 177486 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 497 | 8 | 3 | 5 | 1.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4637980 | 177486 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 497 | 8 | 3 | 5 | 1.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
156021297 | 178194 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 511 | 8 | 3 | 5 | 2.0 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4647797 | 178194 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 511 | 8 | 3 | 5 | 2.0 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
11584048 | 98082 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 491 | 6 | 2 | 6 | 5.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1Cl | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL272993 | 98082 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 491 | 6 | 2 | 6 | 5.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1Cl | 10.1016/j.bmcl.2007.12.021 | |||
24755624 | 157392 | None | 2 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 455 | 6 | 2 | 6 | 4.3 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL407706 | 157392 | None | 2 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 455 | 6 | 2 | 6 | 4.3 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
24755624 | 157392 | None | 2 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 455 | 6 | 2 | 6 | 4.3 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL407706 | 157392 | None | 2 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 455 | 6 | 2 | 6 | 4.3 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1 | 10.1016/j.bmcl.2008.12.042 | |||
69197353 | 88979 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 477 | 6 | 2 | 7 | 4.8 | COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364408 | 88979 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 477 | 6 | 2 | 7 | 4.8 | COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
44454060 | 155422 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 461 | 12 | 2 | 8 | 2.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1 | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL403180 | 155422 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 461 | 12 | 2 | 8 | 2.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1 | 10.1016/j.bmcl.2008.01.100 | |||
10553921 | 104616 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 517 | 9 | 4 | 4 | 2.9 | CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL310457 | 104616 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 517 | 9 | 4 | 4 | 2.9 | CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1 | 10.1016/j.bmc.2007.01.057 | |||
10345516 | 139362 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 491 | 11 | 1 | 4 | 4.9 | CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL379074 | 139362 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 491 | 11 | 1 | 4 | 4.9 | CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1 | 10.1016/j.bmc.2007.01.057 | |||
127047525 | 139854 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 858 | 20 | 7 | 9 | 5.9 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3798559 | 139854 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 858 | 20 | 7 | 9 | 5.9 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
156022162 | 178311 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 557 | 8 | 3 | 7 | 2.3 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4649634 | 178311 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 557 | 8 | 3 | 7 | 2.3 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1 | 10.1021/acs.jmedchem.0c00828 | |||
156012122 | 177486 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 497 | 8 | 3 | 5 | 1.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4637980 | 177486 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 497 | 8 | 3 | 5 | 1.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
20600693 | 63476 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 566 | 11 | 1 | 6 | 4.4 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C(=O)N(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL179785 | 63476 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 566 | 11 | 1 | 6 | 4.4 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C(=O)N(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
44560945 | 179208 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 391 | 9 | 2 | 7 | 2.1 | CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCC#N | 10.1016/j.bmcl.2008.05.100 | |||
CHEMBL471751 | 179208 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 391 | 9 | 2 | 7 | 2.1 | CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCC#N | 10.1016/j.bmcl.2008.05.100 | |||
216208 | 9729 | None | 23 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -5 | 2 | ChEMBL | 505 | 9 | 2 | 6 | 1.7 | CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL113313 | 9729 | None | 23 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -5 | 2 | ChEMBL | 505 | 9 | 2 | 6 | 1.7 | CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O | 10.1021/acs.jmedchem.8b00322 | |||
44449891 | 96527 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 539 | 16 | 4 | 10 | 1.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCCCO | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL262358 | 96527 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 539 | 16 | 4 | 10 | 1.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCCCO | 10.1016/j.bmcl.2008.03.059 | |||
216208 | 9729 | None | 23 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -5 | 2 | ChEMBL | 505 | 9 | 2 | 6 | 1.7 | CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL113313 | 9729 | None | 23 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -5 | 2 | ChEMBL | 505 | 9 | 2 | 6 | 1.7 | CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O | 10.1021/acs.jmedchem.8b00322 | |||
156021478 | 178160 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 509 | 7 | 4 | 5 | 1.8 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4647258 | 178160 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 509 | 7 | 4 | 5 | 1.8 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44437955 | 10327 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 534 | 11 | 4 | 6 | 2.6 | NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1162063 | 10327 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 534 | 11 | 4 | 6 | 2.6 | NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21 | 10.1016/j.bmc.2007.01.057 | |||
9807597 | 183123 | None | 5 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 513 | 7 | 4 | 4 | 3.5 | CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL47938 | 183123 | None | 5 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 513 | 7 | 4 | 4 | 3.5 | CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1 | 10.1016/j.bmc.2007.01.057 | |||
156018364 | 178018 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 498 | 8 | 3 | 6 | 1.0 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4645148 | 178018 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 498 | 8 | 3 | 6 | 1.0 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
156021478 | 178160 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 509 | 7 | 4 | 5 | 1.8 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4647258 | 178160 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 509 | 7 | 4 | 5 | 1.8 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
156022090 | 178308 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 571 | 7 | 2 | 7 | 2.6 | CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4649603 | 178308 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 571 | 7 | 2 | 7 | 2.6 | CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
156022162 | 178311 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 557 | 8 | 3 | 7 | 2.3 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4649634 | 178311 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 557 | 8 | 3 | 7 | 2.3 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1 | 10.1021/acs.jmedchem.0c00828 | |||
56926175 | 69035 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 494 | 4 | 3 | 5 | 2.1 | CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O | nan | |||
CHEMBL1923504 | 69035 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 494 | 4 | 3 | 5 | 2.1 | CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O | nan | |||
56926356 | 69041 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 510 | 4 | 4 | 6 | 1.8 | CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O | nan | |||
CHEMBL1923512 | 69041 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 510 | 4 | 4 | 6 | 1.8 | CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O | nan | |||
56926461 | 69058 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 522 | 4 | 3 | 5 | 2.7 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL1923609 | 69058 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 522 | 4 | 3 | 5 | 2.7 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
56926462 | 69059 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 506 | 3 | 3 | 5 | 2.1 | C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C | nan | |||
CHEMBL1923610 | 69059 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 506 | 3 | 3 | 5 | 2.1 | C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C | nan | |||
57399248 | 69066 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 556 | 4 | 3 | 5 | 3.4 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL1923617 | 69066 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 556 | 4 | 3 | 5 | 3.4 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
11664206 | 69075 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 574 | 3 | 3 | 5 | 3.1 | C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C | nan | |||
CHEMBL1923626 | 69075 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 574 | 3 | 3 | 5 | 3.1 | C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C | nan | |||
56926894 | 69086 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 538 | 3 | 3 | 5 | 2.6 | C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1 | nan | |||
CHEMBL1923638 | 69086 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 538 | 3 | 3 | 5 | 2.6 | C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1 | nan | |||
11526745 | 69090 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 542 | 3 | 3 | 5 | 2.3 | C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C | nan | |||
CHEMBL1923642 | 69090 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 542 | 3 | 3 | 5 | 2.3 | C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C | nan | |||
11526696 | 71626 | None | 17 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 538 | 3 | 3 | 5 | 2.6 | C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1 | nan | |||
CHEMBL1923502 | 71626 | None | 17 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 538 | 3 | 3 | 5 | 2.6 | C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1 | nan | |||
CHEMBL1963249 | 71626 | None | 17 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 538 | 3 | 3 | 5 | 2.6 | C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1 | nan | |||
134130631 | 142460 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 576 | 5 | 4 | 6 | 3.4 | COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1 | nan | |||
CHEMBL3889512 | 142460 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 576 | 5 | 4 | 6 | 3.4 | COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1 | nan | |||
134137202 | 142913 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 552 | 5 | 3 | 6 | 2.7 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL3893048 | 142913 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 552 | 5 | 3 | 6 | 2.7 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
134137257 | 143224 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 540 | 4 | 3 | 5 | 2.8 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL3895776 | 143224 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 540 | 4 | 3 | 5 | 2.8 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
134133518 | 143540 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 552 | 2 | 4 | 5 | 3.4 | CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O | nan | |||
CHEMBL3898348 | 143540 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 552 | 2 | 4 | 5 | 3.4 | CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O | nan | |||
134133352 | 143592 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 556 | 4 | 3 | 5 | 3.4 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL3898794 | 143592 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 556 | 4 | 3 | 5 | 3.4 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
134134286 | 143781 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 598 | 5 | 3 | 5 | 4.4 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL3900284 | 143781 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 598 | 5 | 3 | 5 | 4.4 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
134135712 | 144226 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 533 | 4 | 4 | 5 | 2.6 | CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O | nan | |||
CHEMBL3903845 | 144226 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 533 | 4 | 4 | 5 | 2.6 | CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O | nan | |||
11512561 | 144457 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 574 | 3 | 3 | 5 | 3.4 | C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C | nan | |||
CHEMBL3905791 | 144457 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 574 | 3 | 3 | 5 | 3.4 | C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C | nan | |||
134133037 | 144655 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 572 | 4 | 3 | 5 | 3.9 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL3907497 | 144655 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 572 | 4 | 3 | 5 | 3.9 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
134132893 | 144951 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 538 | 4 | 4 | 6 | 2.4 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL3909834 | 144951 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 538 | 4 | 4 | 6 | 2.4 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
134132152 | 145020 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 572 | 4 | 3 | 5 | 3.9 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL3910300 | 145020 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 572 | 4 | 3 | 5 | 3.9 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
134142218 | 145375 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 564 | 4 | 4 | 5 | 3.5 | CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O | nan | |||
CHEMBL3913052 | 145375 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 564 | 4 | 4 | 5 | 3.5 | CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O | nan | |||
134142433 | 145414 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 534 | 3 | 4 | 6 | 1.8 | CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O | nan | |||
CHEMBL3913335 | 145414 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 534 | 3 | 4 | 6 | 1.8 | CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O | nan | |||
134142839 | 145474 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 520 | 4 | 3 | 5 | 2.8 | CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL3913855 | 145474 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 520 | 4 | 3 | 5 | 2.8 | CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
134143635 | 145662 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 580 | 4 | 4 | 5 | 4.0 | CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O | nan | |||
CHEMBL3915269 | 145662 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 580 | 4 | 4 | 5 | 4.0 | CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O | nan | |||
134143366 | 145848 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 578 | 4 | 4 | 4 | 4.6 | CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O | nan | |||
CHEMBL3916659 | 145848 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 578 | 4 | 4 | 4 | 4.6 | CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O | nan | |||
134142204 | 146025 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 580 | 4 | 4 | 5 | 4.0 | CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O | nan | |||
CHEMBL3918046 | 146025 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 580 | 4 | 4 | 5 | 4.0 | CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O | nan | |||
11584702 | 146279 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 540 | 3 | 3 | 5 | 2.7 | C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C | nan | |||
CHEMBL3920049 | 146279 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 540 | 3 | 3 | 5 | 2.7 | C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C | nan | |||
134140270 | 146461 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 536 | 4 | 3 | 5 | 3.1 | CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL3921499 | 146461 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 536 | 4 | 3 | 5 | 3.1 | CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
134139279 | 146535 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 594 | 4 | 4 | 5 | 4.1 | CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O | nan | |||
CHEMBL3922056 | 146535 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 594 | 4 | 4 | 5 | 4.1 | CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O | nan | |||
134139286 | 146642 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 580 | 4 | 4 | 5 | 4.0 | CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O | nan | |||
CHEMBL3922810 | 146642 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 580 | 4 | 4 | 5 | 4.0 | CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O | nan | |||
134141886 | 147206 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 546 | 4 | 4 | 5 | 3.4 | CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O | nan | |||
CHEMBL3927481 | 147206 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 546 | 4 | 4 | 5 | 3.4 | CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O | nan | |||
117812380 | 147840 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 617 | 5 | 4 | 7 | 1.6 | C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C | nan | |||
CHEMBL3932408 | 147840 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 617 | 5 | 4 | 7 | 1.6 | C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C | nan | |||
134138595 | 147843 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 544 | 2 | 4 | 5 | 3.3 | O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1 | nan | |||
CHEMBL3932434 | 147843 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 544 | 2 | 4 | 5 | 3.3 | O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1 | nan | |||
134138824 | 148102 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 525 | 3 | 3 | 6 | 1.6 | C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C | nan | |||
CHEMBL3934402 | 148102 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 525 | 3 | 3 | 6 | 1.6 | C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C | nan | |||
134148504 | 148442 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 518 | 4 | 3 | 4 | 3.4 | CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL3937200 | 148442 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 518 | 4 | 3 | 4 | 3.4 | CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
134149306 | 148562 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 520 | 3 | 3 | 5 | 1.6 | C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C | nan | |||
CHEMBL3938104 | 148562 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 520 | 3 | 3 | 5 | 1.6 | C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C | nan | |||
134145791 | 148874 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 596 | 3 | 3 | 5 | 2.8 | C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C | nan | |||
CHEMBL3940705 | 148874 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 596 | 3 | 3 | 5 | 2.8 | C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C | nan | |||
134145564 | 149178 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 518 | 4 | 3 | 4 | 3.3 | CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL3943086 | 149178 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 518 | 4 | 3 | 4 | 3.3 | CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
134147441 | 149577 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 538 | 2 | 4 | 5 | 3.0 | C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O | nan | |||
CHEMBL3946348 | 149577 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 538 | 2 | 4 | 5 | 3.0 | C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O | nan | |||
134155239 | 151103 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 564 | 3 | 4 | 5 | 3.4 | O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1 | nan | |||
CHEMBL3958460 | 151103 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 564 | 3 | 4 | 5 | 3.4 | O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1 | nan | |||
134155132 | 151181 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 502 | 4 | 3 | 5 | 2.9 | CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL3959108 | 151181 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 502 | 4 | 3 | 5 | 2.9 | CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
134154079 | 152492 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 512 | 4 | 4 | 5 | 3.2 | CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O | nan | |||
CHEMBL3970499 | 152492 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 512 | 4 | 4 | 5 | 3.2 | CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O | nan | |||
134153247 | 152809 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 582 | 4 | 4 | 6 | 2.9 | CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O | nan | |||
CHEMBL3973085 | 152809 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 582 | 4 | 4 | 6 | 2.9 | CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O | nan | |||
44570763 | 190368 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 449 | 4 | 1 | 4 | 2.7 | N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(F)ccc3F)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL517543 | 190368 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 449 | 4 | 1 | 4 | 2.7 | N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(F)ccc3F)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
9890504 | 89774 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 461 | 10 | 3 | 10 | -0.0 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)N1CC[C@@H](O)C1 | 10.1021/jm7010595 | |||
CHEMBL237699 | 89774 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 461 | 10 | 3 | 10 | -0.0 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)N1CC[C@@H](O)C1 | 10.1021/jm7010595 | |||
24969109 | 88909 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 444 | 5 | 2 | 6 | 3.8 | Cc1ccc(-c2ccc(S(=O)(=O)Nc3cccc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364338 | 88909 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 444 | 5 | 2 | 6 | 3.8 | Cc1ccc(-c2ccc(S(=O)(=O)Nc3cccc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1 | 10.6019/CHEMBL2364335 | |||
11518200 | 88924 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 457 | 6 | 2 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364353 | 88924 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 457 | 6 | 2 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
11641108 | 88953 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 457 | 6 | 2 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364382 | 88953 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 457 | 6 | 2 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
69197887 | 88974 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2C)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364403 | 88974 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2C)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
44447856 | 161908 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 558 | 15 | 4 | 12 | 1.6 | Cc1noc(C)c1-c1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
CHEMBL414394 | 161908 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 558 | 15 | 4 | 12 | 1.6 | Cc1noc(C)c1-c1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
156018364 | 178018 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 498 | 8 | 3 | 6 | 1.0 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4645148 | 178018 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 498 | 8 | 3 | 6 | 1.0 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
156022090 | 178308 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 571 | 7 | 2 | 7 | 2.6 | CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4649603 | 178308 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 571 | 7 | 2 | 7 | 2.6 | CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
10323604 | 10311 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 497 | 7 | 2 | 5 | 2.6 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161828 | 10311 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 497 | 7 | 2 | 5 | 2.6 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
10323604 | 10311 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 497 | 7 | 2 | 5 | 2.6 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161828 | 10311 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 497 | 7 | 2 | 5 | 2.6 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
44447853 | 95017 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 493 | 15 | 4 | 11 | 0.3 | COc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
CHEMBL254565 | 95017 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 493 | 15 | 4 | 11 | 0.3 | COc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
25022503 | 155653 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 540 | 15 | 4 | 11 | 1.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1cccnc1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
CHEMBL404355 | 155653 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 540 | 15 | 4 | 11 | 1.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1cccnc1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
44269035 | 27340 | None | 0 | Rat | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 490 | 5 | 4 | 5 | 2.8 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(O)c3ccccc3O2)C1 | 10.1016/s0960-894x(97)10199-8 | |||
CHEMBL13675 | 27340 | None | 0 | Rat | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 490 | 5 | 4 | 5 | 2.8 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(O)c3ccccc3O2)C1 | 10.1016/s0960-894x(97)10199-8 | |||
44269039 | 98394 | None | 0 | Rat | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 488 | 5 | 3 | 5 | 3.0 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@@]2(CC(=O)c3ccccc3O2)C1 | 10.1016/s0960-894x(97)10199-8 | |||
CHEMBL275093 | 98394 | None | 0 | Rat | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 488 | 5 | 3 | 5 | 3.0 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@@]2(CC(=O)c3ccccc3O2)C1 | 10.1016/s0960-894x(97)10199-8 | |||
145956061 | 162788 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 432 | 4 | 3 | 4 | 2.3 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4170481 | 162788 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 432 | 4 | 3 | 4 | 2.3 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
44570965 | 189946 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 418 | 4 | 2 | 6 | 0.8 | Cc1ccc(-c2ccc(S(=O)(=O)N3CCNC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL516602 | 189946 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 418 | 4 | 2 | 6 | 0.8 | Cc1ccc(-c2ccc(S(=O)(=O)N3CCNC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1 | 10.1016/j.bmcl.2008.12.042 | |||
69194933 | 88996 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 455 | 5 | 2 | 5 | 5.0 | Cc1csc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3C)cc2)c1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364424 | 88996 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 455 | 5 | 2 | 5 | 5.0 | Cc1csc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3C)cc2)c1 | 10.6019/CHEMBL2364335 | |||
69198297 | 89005 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364432 | 89005 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
44447850 | 94988 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 488 | 14 | 4 | 11 | 0.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1C#N)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
CHEMBL254363 | 94988 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 488 | 14 | 4 | 11 | 0.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1C#N)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
44450015 | 96371 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 475 | 16 | 4 | 9 | 0.8 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCO | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL261358 | 96371 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 475 | 16 | 4 | 9 | 0.8 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCO | 10.1016/j.bmcl.2008.03.059 | |||
178024 | 1971 | None | 27 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -1 | 3 | ChEMBL | 528 | 8 | 2 | 6 | 1.8 | O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C | 10.1016/j.bmc.2007.01.057 | |||
5867 | 1971 | None | 27 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -1 | 3 | ChEMBL | 528 | 8 | 2 | 6 | 1.8 | O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL13817 | 1971 | None | 27 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -1 | 3 | ChEMBL | 528 | 8 | 2 | 6 | 1.8 | O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C | 10.1016/j.bmc.2007.01.057 | |||
178024 | 1971 | None | 27 | Rat | Functional | pEC50 | = | 8.9 | 8.9 | 1 | 3 | ChEMBL | 528 | 8 | 2 | 6 | 1.8 | O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C | 10.1016/s0960-894x(97)10199-8 | |||
5867 | 1971 | None | 27 | Rat | Functional | pEC50 | = | 8.9 | 8.9 | 1 | 3 | ChEMBL | 528 | 8 | 2 | 6 | 1.8 | O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C | 10.1016/s0960-894x(97)10199-8 | |||
CHEMBL13817 | 1971 | None | 27 | Rat | Functional | pEC50 | = | 8.9 | 8.9 | 1 | 3 | ChEMBL | 528 | 8 | 2 | 6 | 1.8 | O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C | 10.1016/s0960-894x(97)10199-8 | |||
178024 | 1971 | None | 27 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -1 | 3 | ChEMBL | 528 | 8 | 2 | 6 | 1.8 | O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C | 10.1016/j.bmc.2007.01.057 | |||
5867 | 1971 | None | 27 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -1 | 3 | ChEMBL | 528 | 8 | 2 | 6 | 1.8 | O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL13817 | 1971 | None | 27 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -1 | 3 | ChEMBL | 528 | 8 | 2 | 6 | 1.8 | O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C | 10.1016/j.bmc.2007.01.057 | |||
145956061 | 162788 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 432 | 4 | 3 | 4 | 2.3 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4170481 | 162788 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 432 | 4 | 3 | 4 | 2.3 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
44450104 | 95854 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 496 | 14 | 4 | 10 | -1.0 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(N)(=O)=O | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL258761 | 95854 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 496 | 14 | 4 | 10 | -1.0 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(N)(=O)=O | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL500468 | 216603 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | None | None | None | CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O | 10.1016/j.bmcl.2008.03.059 | |||||
CHEMBL500468 | 216603 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | None | None | None | CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O | 10.1021/jm300414b | |||||
22888475 | 63846 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 523 | 9 | 1 | 6 | 5.4 | CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C=O)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL180246 | 63846 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 523 | 9 | 1 | 6 | 5.4 | CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C=O)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL500468 | 216603 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | None | None | None | CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O | 10.1016/j.bmcl.2005.02.040 | |||||
162653916 | 180651 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 707 | 15 | 3 | 8 | 6.1 | COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL4753794 | 180651 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 707 | 15 | 3 | 8 | 6.1 | COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL500468 | 216603 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | None | None | None | CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O | 10.1016/j.bmcl.2008.02.021 | |||||
CHEMBL500468 | 216603 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | None | None | None | CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O | 10.1016/j.bmcl.2008.05.100 | |||||
178024 | 1971 | None | 27 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -1 | 3 | ChEMBL | 528 | 8 | 2 | 6 | 1.8 | O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C | 10.1016/s0960-894x(01)00324-9 | |||
5867 | 1971 | None | 27 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -1 | 3 | ChEMBL | 528 | 8 | 2 | 6 | 1.8 | O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C | 10.1016/s0960-894x(01)00324-9 | |||
CHEMBL13817 | 1971 | None | 27 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -1 | 3 | ChEMBL | 528 | 8 | 2 | 6 | 1.8 | O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C | 10.1016/s0960-894x(01)00324-9 | |||
156012849 | 177403 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 512 | 8 | 3 | 6 | 1.3 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4636571 | 177403 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 512 | 8 | 3 | 6 | 1.3 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44390996 | 64325 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 563 | 8 | 1 | 5 | 6.6 | CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(C(F)(F)F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL181063 | 64325 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 563 | 8 | 1 | 5 | 6.6 | CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(C(F)(F)F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
11353414 | 64637 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 553 | 11 | 1 | 7 | 4.5 | COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL181764 | 64637 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 553 | 11 | 1 | 7 | 4.5 | COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
11353414 | 64637 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 553 | 11 | 1 | 7 | 4.5 | COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL181764 | 64637 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 553 | 11 | 1 | 7 | 4.5 | COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
44347919 | 16380 | None | 0 | Rat | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 606 | 14 | 3 | 6 | 4.2 | C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
CHEMBL122939 | 16380 | None | 0 | Rat | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 606 | 14 | 3 | 6 | 4.2 | C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
16133832 | 215792 | None | 15 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C | 10.1021/acs.jmedchem.8b01644 | |||||
CHEMBL425281 | 215792 | None | 15 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C | 10.1021/acs.jmedchem.8b01644 | |||||
145957574 | 162395 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | 57 | 2 | ChEMBL | 390 | 6 | 3 | 3 | 2.3 | CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4164328 | 162395 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | 57 | 2 | ChEMBL | 390 | 6 | 3 | 3 | 2.3 | CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
9875705 | 207759 | None | 1 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 518 | 9 | 3 | 5 | 3.3 | CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL79263 | 207759 | None | 1 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 518 | 9 | 3 | 5 | 3.3 | CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1 | 10.1016/j.bmc.2007.01.057 | |||
156012849 | 177403 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 512 | 8 | 3 | 6 | 1.3 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4636571 | 177403 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 512 | 8 | 3 | 6 | 1.3 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
156013219 | 177594 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | 60 | 3 | ChEMBL | 404 | 6 | 3 | 3 | 2.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4639379 | 177594 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | 60 | 3 | ChEMBL | 404 | 6 | 3 | 3 | 2.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
11648350 | 88952 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 463 | 6 | 2 | 7 | 4.5 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364381 | 88952 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 463 | 6 | 2 | 7 | 4.5 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
59007043 | 88955 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 459 | 5 | 2 | 5 | 4.5 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(Cl)cccc2c1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364384 | 88955 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 459 | 5 | 2 | 5 | 4.5 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(Cl)cccc2c1 | 10.6019/CHEMBL2364335 | |||
69197106 | 88998 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 477 | 6 | 2 | 7 | 4.8 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)s3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364426 | 88998 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 477 | 6 | 2 | 7 | 4.8 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)s3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
24803348 | 89003 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 459 | 6 | 2 | 6 | 4.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1F | 10.6019/CHEMBL2364335 | |||
CHEMBL2364430 | 89003 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 459 | 6 | 2 | 6 | 4.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1F | 10.6019/CHEMBL2364335 | |||
69197228 | 89049 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 445 | 5 | 2 | 5 | 4.6 | C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364475 | 89049 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 445 | 5 | 2 | 5 | 4.6 | C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
16114291 | 191403 | None | 1 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 562 | 11 | 3 | 6 | 5.0 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c02191 | |||
CHEMBL5190973 | 191403 | None | 1 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 562 | 11 | 3 | 6 | 5.0 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c02191 | |||
16114292 | 96987 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 601 | 11 | 4 | 6 | 5.5 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1 | 10.1021/jm701292s | |||
CHEMBL266063 | 96987 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 601 | 11 | 4 | 6 | 5.5 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1 | 10.1021/jm701292s | |||
9875705 | 207759 | None | 1 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 518 | 9 | 3 | 5 | 3.3 | CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL79263 | 207759 | None | 1 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 518 | 9 | 3 | 5 | 3.3 | CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1 | 10.1016/j.bmc.2007.01.057 | |||
44436850 | 91583 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 564 | 11 | 4 | 6 | 4.6 | COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1 | 10.1021/jm0704550 | |||
CHEMBL240509 | 91583 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 564 | 11 | 4 | 6 | 4.6 | COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1 | 10.1021/jm0704550 | |||
44447840 | 95045 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 497 | 14 | 4 | 10 | 0.9 | CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
CHEMBL254766 | 95045 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 497 | 14 | 4 | 10 | 0.9 | CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
44447854 | 95018 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 469 | 14 | 4 | 10 | 0.7 | CC(C)(N)C(=O)N[C@H](COCC1CCCCC1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
CHEMBL254566 | 95018 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 469 | 14 | 4 | 10 | 0.7 | CC(C)(N)C(=O)N[C@H](COCC1CCCCC1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
CHEMBL105462 | 210927 | None | 22 | Rat | Functional | pEC50 | = | 8.8 | 8.8 | 12 | 2 | ChEMBL | None | None | None | C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm980197u | |||||
44447844 | 94930 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 531 | 14 | 4 | 10 | 1.3 | CC(C)(N)C(=O)N[C@H](COCc1cccc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
CHEMBL253965 | 94930 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 531 | 14 | 4 | 10 | 1.3 | CC(C)(N)C(=O)N[C@H](COCc1cccc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
44450017 | 96399 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 461 | 15 | 4 | 9 | 0.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCO | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL261544 | 96399 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 461 | 15 | 4 | 9 | 0.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCO | 10.1016/j.bmcl.2008.03.059 | |||
10118326 | 24101 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 509 | 9 | 4 | 4 | 3.7 | O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL133848 | 24101 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 509 | 9 | 4 | 4 | 3.7 | O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1 | 10.1016/j.bmc.2007.01.057 | |||
10458218 | 27495 | None | 0 | Rat | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 488 | 5 | 3 | 5 | 3.0 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(=O)c3ccccc3O2)C1 | 10.1016/s0960-894x(97)10199-8 | |||
CHEMBL13687 | 27495 | None | 0 | Rat | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 488 | 5 | 3 | 5 | 3.0 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(=O)c3ccccc3O2)C1 | 10.1016/s0960-894x(97)10199-8 | |||
10745618 | 113050 | None | 0 | Rat | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 568 | 13 | 2 | 4 | 4.5 | CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CC1 | 10.1021/jm980197u | |||
CHEMBL331093 | 113050 | None | 0 | Rat | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 568 | 13 | 2 | 4 | 4.5 | CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CC1 | 10.1021/jm980197u | |||
10118326 | 24101 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 509 | 9 | 4 | 4 | 3.7 | O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL133848 | 24101 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 509 | 9 | 4 | 4 | 3.7 | O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1 | 10.1016/j.bmc.2007.01.057 | |||
156010457 | 177159 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 557 | 7 | 3 | 7 | 2.3 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4632657 | 177159 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 557 | 7 | 3 | 7 | 2.3 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1 | 10.1021/acs.jmedchem.0c00828 | |||
23649669 | 154056 | None | 9 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 463 | 14 | 4 | 10 | 0.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL398372 | 154056 | None | 9 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 463 | 14 | 4 | 10 | 0.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.03.059 | |||
23649669 | 154056 | None | 9 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 463 | 14 | 4 | 10 | 0.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO | 10.1021/jm7010595 | |||
CHEMBL398372 | 154056 | None | 9 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 463 | 14 | 4 | 10 | 0.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO | 10.1021/jm7010595 | |||
23649669 | 154056 | None | 9 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 463 | 14 | 4 | 10 | 0.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.05.100 | |||
CHEMBL398372 | 154056 | None | 9 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 463 | 14 | 4 | 10 | 0.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.05.100 | |||
23649669 | 154056 | None | 9 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 463 | 14 | 4 | 10 | 0.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
CHEMBL398372 | 154056 | None | 9 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 463 | 14 | 4 | 10 | 0.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
44437955 | 10327 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 534 | 11 | 4 | 6 | 2.6 | NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1162063 | 10327 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 534 | 11 | 4 | 6 | 2.6 | NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21 | 10.1016/j.bmc.2007.01.057 | |||
10626337 | 101279 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 543 | 9 | 5 | 5 | 2.8 | CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL295984 | 101279 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 543 | 9 | 5 | 5 | 2.8 | CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O | 10.1016/j.bmc.2007.01.057 | |||
156010457 | 177159 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 557 | 7 | 3 | 7 | 2.3 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4632657 | 177159 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 557 | 7 | 3 | 7 | 2.3 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1 | 10.1021/acs.jmedchem.0c00828 | |||
156012445 | 177440 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 499 | 8 | 3 | 7 | 0.4 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4637284 | 177440 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 499 | 8 | 3 | 7 | 0.4 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
156015928 | 177686 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 512 | 8 | 3 | 6 | 1.4 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4640615 | 177686 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 512 | 8 | 3 | 6 | 1.4 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44452750 | 96310 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 481 | 7 | 2 | 6 | 4.4 | COc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL261030 | 96310 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 481 | 7 | 2 | 6 | 4.4 | COc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1 | 10.1016/j.bmcl.2007.12.021 | |||
44452932 | 97640 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 475 | 6 | 2 | 6 | 4.6 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1F | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL270790 | 97640 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 475 | 6 | 2 | 6 | 4.6 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1F | 10.1016/j.bmcl.2007.12.021 | |||
44570700 | 184065 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 486 | 6 | 2 | 6 | 2.1 | COc1cccc(C(=O)Nc2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2)c1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL481620 | 184065 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 486 | 6 | 2 | 6 | 2.1 | COc1cccc(C(=O)Nc2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2)c1 | 10.1016/j.bmcl.2008.12.042 | |||
69197169 | 88970 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 463 | 6 | 2 | 7 | 4.5 | COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364399 | 88970 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 463 | 6 | 2 | 7 | 4.5 | COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
11641478 | 88978 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 477 | 6 | 2 | 7 | 4.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)s1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364407 | 88978 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 477 | 6 | 2 | 7 | 4.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)s1 | 10.6019/CHEMBL2364335 | |||
24803350 | 89014 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 455 | 6 | 2 | 6 | 4.3 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1C | 10.6019/CHEMBL2364335 | |||
CHEMBL2364441 | 89014 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 455 | 6 | 2 | 6 | 4.3 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1C | 10.6019/CHEMBL2364335 | |||
11547664 | 89054 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 489 | 6 | 2 | 6 | 4.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)c(F)c1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364480 | 89054 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 489 | 6 | 2 | 6 | 4.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)c(F)c1 | 10.6019/CHEMBL2364335 | |||
44579802 | 186874 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 406 | 7 | 1 | 3 | 4.5 | CC(Oc1ccccc1Cl)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL488965 | 186874 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 406 | 7 | 1 | 3 | 4.5 | CC(Oc1ccccc1Cl)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
44444572 | 94072 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 498 | 5 | 1 | 7 | 4.1 | COc1cc2c(cc1N1C[C@@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
CHEMBL248745 | 94072 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 498 | 5 | 1 | 7 | 4.1 | COc1cc2c(cc1N1C[C@@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
145962494 | 162168 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 446 | 4 | 2 | 5 | 2.4 | CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4160705 | 162168 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 446 | 4 | 2 | 5 | 2.4 | CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
145951150 | 162871 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 443 | 4 | 3 | 5 | 3.1 | Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4171914 | 162871 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 443 | 4 | 3 | 5 | 3.1 | Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21 | 10.1021/acs.jmedchem.8b00322 | |||
44434120 | 89941 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 523 | 15 | 3 | 9 | 2.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL237926 | 89941 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 523 | 15 | 3 | 9 | 2.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1 | 10.1016/j.bmcl.2007.07.099 | |||
9827234 | 5338 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 498 | 9 | 5 | 4 | 3.1 | O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1c[nH]c2ccccc12)C1CCNCC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL106841 | 5338 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 498 | 9 | 5 | 4 | 3.1 | O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1c[nH]c2ccccc12)C1CCNCC1 | 10.1016/j.bmc.2007.01.057 | |||
44411718 | 10308 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 467 | 7 | 2 | 5 | 3.1 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161825 | 10308 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 467 | 7 | 2 | 5 | 3.1 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
44437953 | 10326 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 522 | 9 | 3 | 6 | 1.5 | NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1162062 | 10326 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 522 | 9 | 3 | 6 | 1.5 | NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21 | 10.1016/j.bmc.2007.01.057 | |||
44293557 | 101142 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | 1 | 2 | ChEMBL | 447 | 7 | 2 | 3 | 3.7 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL294923 | 101142 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | 1 | 2 | ChEMBL | 447 | 7 | 2 | 3 | 3.7 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL540001 | 101142 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | 1 | 2 | ChEMBL | 447 | 7 | 2 | 3 | 3.7 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/j.bmc.2007.01.057 | |||
127046473 | 139867 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 661 | 17 | 6 | 8 | 4.2 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3798645 | 139867 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 661 | 17 | 6 | 8 | 4.2 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
156012203 | 177439 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 558 | 7 | 3 | 8 | 1.6 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4637255 | 177439 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 558 | 7 | 3 | 8 | 1.6 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1 | 10.1021/acs.jmedchem.0c00828 | |||
156016696 | 177735 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 478 | 8 | 3 | 5 | 0.4 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4641201 | 177735 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 478 | 8 | 3 | 5 | 0.4 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
11525404 | 95434 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 458 | 6 | 2 | 7 | 3.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL256808 | 95434 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 458 | 6 | 2 | 7 | 3.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1 | 10.1016/j.bmcl.2007.12.021 | |||
44571004 | 184152 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 431 | 5 | 1 | 5 | 2.6 | CNC1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccc(C)o3)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL482203 | 184152 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 431 | 5 | 1 | 5 | 2.6 | CNC1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccc(C)o3)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL105462 | 210927 | None | 22 | Rat | Functional | pEC50 | = | 8 | 8.0 | 12 | 2 | ChEMBL | None | None | None | C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1016/s0960-894x(97)10199-8 | |||||
24969294 | 88914 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 460 | 5 | 3 | 6 | 3.1 | Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)c[nH]c3=O)cc2F)o1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364343 | 88914 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 460 | 5 | 3 | 6 | 3.1 | Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)c[nH]c3=O)cc2F)o1 | 10.6019/CHEMBL2364335 | |||
69194607 | 88929 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 466 | 6 | 2 | 6 | 4.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364358 | 88929 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 466 | 6 | 2 | 6 | 4.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1 | 10.6019/CHEMBL2364335 | |||
69197049 | 88930 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 472 | 6 | 2 | 7 | 4.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)s1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364359 | 88930 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 472 | 6 | 2 | 7 | 4.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)s1 | 10.6019/CHEMBL2364335 | |||
69195141 | 88948 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 431 | 5 | 2 | 6 | 3.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1csc2ccccc12 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364377 | 88948 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 431 | 5 | 2 | 6 | 3.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1csc2ccccc12 | 10.6019/CHEMBL2364335 | |||
11682686 | 88961 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 395 | 4 | 2 | 4 | 3.8 | C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc4ccccc34)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364390 | 88961 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 395 | 4 | 2 | 4 | 3.8 | C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc4ccccc34)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
69198021 | 89004 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 459 | 5 | 2 | 5 | 4.5 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccc(Cl)c12 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364431 | 89004 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 459 | 5 | 2 | 5 | 4.5 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccc(Cl)c12 | 10.6019/CHEMBL2364335 | |||
11655608 | 89017 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 463 | 5 | 2 | 5 | 4.7 | C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)c(F)c3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364444 | 89017 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 463 | 5 | 2 | 5 | 4.7 | C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)c(F)c3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
69194649 | 89051 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 479 | 5 | 2 | 5 | 5.2 | C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364477 | 89051 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 479 | 5 | 2 | 5 | 5.2 | C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
69196750 | 89053 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 472 | 6 | 2 | 7 | 4.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)nc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364479 | 89053 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 472 | 6 | 2 | 7 | 4.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)nc1 | 10.6019/CHEMBL2364335 | |||
23730339 | 148207 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 475 | 10 | 3 | 10 | 0.4 | CC1(O)CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1 | 10.1021/jm7010595 | |||
CHEMBL393531 | 148207 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 475 | 10 | 3 | 10 | 0.4 | CC1(O)CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1 | 10.1021/jm7010595 | |||
156016696 | 177735 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 478 | 8 | 3 | 5 | 0.4 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4641201 | 177735 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 478 | 8 | 3 | 5 | 0.4 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
145993528 | 167414 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 561 | 5 | 1 | 4 | 6.6 | C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4294083 | 167414 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 561 | 5 | 1 | 4 | 6.6 | C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
156012203 | 177439 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 558 | 7 | 3 | 8 | 1.6 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4637255 | 177439 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 558 | 7 | 3 | 8 | 1.6 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1 | 10.1021/acs.jmedchem.0c00828 | |||
145950201 | 163037 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 404 | 6 | 3 | 3 | 2.9 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4174476 | 163037 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 404 | 6 | 3 | 3 | 2.9 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
44281466 | 169485 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 436 | 8 | 2 | 4 | 2.9 | Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL442151 | 169485 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 436 | 8 | 2 | 4 | 2.9 | Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1 | 10.1016/j.bmc.2007.01.057 | |||
44452806 | 96736 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 486 | 7 | 2 | 7 | 4.6 | CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL263916 | 96736 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 486 | 7 | 2 | 7 | 4.6 | CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1 | 10.1016/j.bmcl.2007.12.021 | |||
44452885 | 97867 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 481 | 8 | 2 | 6 | 4.3 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(OCc2ccccc2)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL271948 | 97867 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 481 | 8 | 2 | 6 | 4.3 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(OCc2ccccc2)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
11633712 | 159429 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 446 | 5 | 2 | 6 | 3.9 | C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL410013 | 159429 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 446 | 5 | 2 | 6 | 3.9 | C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1 | 10.1016/j.bmcl.2007.12.021 | |||
57390496 | 69077 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 552 | 3 | 3 | 5 | 2.9 | Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F | 10.1021/jm2007062 | |||
CHEMBL1923628 | 69077 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 552 | 3 | 3 | 5 | 2.9 | Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F | 10.1021/jm2007062 | |||
56926782 | 69079 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 472 | 4 | 3 | 4 | 3.0 | CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL1923631 | 69079 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 472 | 4 | 3 | 4 | 3.0 | CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
56926785 | 69082 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 508 | 4 | 3 | 5 | 2.3 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL1923634 | 69082 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 508 | 4 | 3 | 5 | 2.3 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
56926892 | 69084 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 534 | 4 | 3 | 4 | 3.7 | CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL1923636 | 69084 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 534 | 4 | 3 | 4 | 3.7 | CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
56926893 | 69085 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 538 | 3 | 3 | 5 | 2.6 | CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1 | nan | |||
CHEMBL1923637 | 69085 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 538 | 3 | 3 | 5 | 2.6 | CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1 | nan | |||
134131183 | 142555 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 548 | 4 | 4 | 5 | 3.3 | CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O | nan | |||
CHEMBL3890296 | 142555 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 548 | 4 | 4 | 5 | 3.3 | CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O | nan | |||
134133488 | 143323 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 600 | 4 | 4 | 5 | 4.1 | CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O | nan | |||
CHEMBL3896536 | 143323 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 600 | 4 | 4 | 5 | 4.1 | CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O | nan | |||
134134870 | 144480 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 534 | 3 | 4 | 5 | 2.9 | CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O | nan | |||
CHEMBL3905987 | 144480 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 534 | 3 | 4 | 5 | 2.9 | CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O | nan | |||
134132958 | 144749 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 536 | 3 | 3 | 5 | 2.4 | C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C | nan | |||
CHEMBL3908264 | 144749 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 536 | 3 | 3 | 5 | 2.4 | C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C | nan | |||
134132265 | 145059 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 548 | 3 | 4 | 6 | 2.2 | CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O | nan | |||
CHEMBL3910661 | 145059 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 548 | 3 | 4 | 6 | 2.2 | CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O | nan | |||
76460236 | 145548 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 472 | 4 | 3 | 4 | 3.0 | CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O | nan | |||
CHEMBL3914338 | 145548 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 472 | 4 | 3 | 4 | 3.0 | CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O | nan | |||
134141159 | 146817 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 523 | 4 | 3 | 6 | 2.1 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL3924192 | 146817 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 523 | 4 | 3 | 6 | 2.1 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
134149092 | 148541 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 520 | 4 | 4 | 5 | 2.5 | CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O | nan | |||
CHEMBL3937924 | 148541 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 520 | 4 | 4 | 5 | 2.5 | CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O | nan | |||
134146570 | 148868 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 548 | 4 | 4 | 5 | 3.3 | CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O | nan | |||
CHEMBL3940653 | 148868 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 548 | 4 | 4 | 5 | 3.3 | CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O | nan | |||
134145820 | 149122 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 506 | 4 | 3 | 4 | 2.9 | CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL3942642 | 149122 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 506 | 4 | 3 | 4 | 2.9 | CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
134155024 | 151101 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 520 | 4 | 3 | 4 | 3.6 | CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL3958451 | 151101 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 520 | 4 | 3 | 4 | 3.6 | CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
134155282 | 151431 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 506 | 4 | 3 | 5 | 2.5 | CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL3961108 | 151431 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 506 | 4 | 3 | 5 | 2.5 | CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
134152627 | 151637 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 504 | 4 | 3 | 4 | 3.0 | CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL3963078 | 151637 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 504 | 4 | 3 | 4 | 3.0 | CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
134150696 | 152168 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 506 | 4 | 3 | 4 | 3.2 | CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O | nan | |||
CHEMBL3967506 | 152168 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 506 | 4 | 3 | 4 | 3.2 | CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O | nan | |||
134150029 | 152204 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 518 | 4 | 3 | 4 | 3.3 | CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O | nan | |||
CHEMBL3967783 | 152204 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 518 | 4 | 3 | 4 | 3.3 | CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O | nan | |||
134153608 | 152459 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 506 | 4 | 3 | 4 | 3.2 | CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL3970180 | 152459 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 506 | 4 | 3 | 4 | 3.2 | CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
134154022 | 152914 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 532 | 4 | 3 | 4 | 3.7 | CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL3973940 | 152914 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 532 | 4 | 3 | 4 | 3.7 | CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
134151899 | 153408 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 492 | 4 | 3 | 5 | 2.2 | CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O | nan | |||
CHEMBL3978207 | 153408 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 492 | 4 | 3 | 5 | 2.2 | CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O | nan | |||
134156625 | 153740 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 472 | 4 | 3 | 5 | 1.7 | CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
CHEMBL3981072 | 153740 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 472 | 4 | 3 | 5 | 1.7 | CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | nan | |||
16040587 | 179490 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -14 | 2 | ChEMBL | 501 | 6 | 2 | 5 | 4.8 | C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 | 10.1021/jm801332q | |||
CHEMBL473921 | 179490 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -14 | 2 | ChEMBL | 501 | 6 | 2 | 5 | 4.8 | C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 | 10.1021/jm801332q | |||
44576247 | 216710 | None | 1 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/acs.jmedchem.1c02191 | |||||
CHEMBL506986 | 216710 | None | 1 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/acs.jmedchem.1c02191 | |||||
44576247 | 216710 | None | 1 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1016/j.bmcl.2016.04.003 | |||||
CHEMBL506986 | 216710 | None | 1 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1016/j.bmcl.2016.04.003 | |||||
CHEMBL3578015 | 214226 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -33 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O | 10.1021/jm501702q | |||||
CHEMBL3578018 | 214229 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -15 | 2 | ChEMBL | None | None | None | CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O | 10.1021/jm501702q | |||||
69198097 | 88935 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 452 | 6 | 2 | 6 | 3.7 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364364 | 88935 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 452 | 6 | 2 | 6 | 3.7 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)cc1 | 10.6019/CHEMBL2364335 | |||
69198438 | 88937 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 458 | 6 | 2 | 7 | 3.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)s1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364366 | 88937 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 458 | 6 | 2 | 7 | 3.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)s1 | 10.6019/CHEMBL2364335 | |||
69196473 | 88946 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 452 | 5 | 2 | 6 | 4.3 | C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)ccc2C#N)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364375 | 88946 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 452 | 5 | 2 | 6 | 4.3 | C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)ccc2C#N)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
69197657 | 88947 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 497 | 8 | 2 | 7 | 4.5 | COc1ccc(Oc2cccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)c2)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364376 | 88947 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 497 | 8 | 2 | 7 | 4.5 | COc1ccc(Oc2cccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)c2)cc1 | 10.6019/CHEMBL2364335 | |||
69195983 | 88968 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 465 | 6 | 2 | 5 | 4.7 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364397 | 88968 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 465 | 6 | 2 | 5 | 4.7 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
69196844 | 88985 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 475 | 6 | 2 | 6 | 4.6 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364414 | 88985 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 475 | 6 | 2 | 6 | 4.6 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
11647817 | 88989 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 437 | 4 | 2 | 4 | 3.7 | Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364418 | 88989 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 437 | 4 | 2 | 4 | 3.7 | Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1 | 10.6019/CHEMBL2364335 | |||
69196864 | 89007 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 487 | 6 | 2 | 5 | 4.6 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(F)cc2F)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364434 | 89007 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 487 | 6 | 2 | 5 | 4.6 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(F)cc2F)cc1 | 10.6019/CHEMBL2364335 | |||
69198407 | 89036 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 471 | 5 | 2 | 5 | 3.6 | COc1cc(Br)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F | 10.6019/CHEMBL2364335 | |||
CHEMBL2364463 | 89036 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 471 | 5 | 2 | 5 | 3.6 | COc1cc(Br)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F | 10.6019/CHEMBL2364335 | |||
44579958 | 191451 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 381 | 7 | 2 | 4 | 3.2 | CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL519171 | 191451 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 381 | 7 | 2 | 4 | 3.2 | CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1 | 10.1016/j.bmcl.2008.07.120 | |||
156020713 | 178193 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 477 | 6 | 3 | 7 | 0.7 | Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4647751 | 178193 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 477 | 6 | 3 | 7 | 0.7 | Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1 | 10.1021/acs.jmedchem.0c00828 | |||
134139753 | 146124 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 508 | 5 | 3 | 5 | 2.5 | CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O | nan | |||
CHEMBL3918783 | 146124 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 508 | 5 | 3 | 5 | 2.5 | CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O | nan | |||
44449923 | 96391 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 601 | 17 | 4 | 11 | 0.7 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(S(=O)(=O)CCO)c1 | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL261497 | 96391 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 601 | 17 | 4 | 11 | 0.7 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(S(=O)(=O)CCO)c1 | 10.1016/j.bmcl.2008.03.059 | |||
156020713 | 178193 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 477 | 6 | 3 | 7 | 0.7 | Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4647751 | 178193 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 477 | 6 | 3 | 7 | 0.7 | Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1 | 10.1021/acs.jmedchem.0c00828 | |||
44434110 | 88546 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 515 | 13 | 3 | 9 | 1.8 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL235135 | 88546 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 515 | 13 | 3 | 9 | 1.8 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL3578018 | 214229 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -15 | 2 | ChEMBL | None | None | None | CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O | 10.1021/jm501702q | |||||
44450102 | 95824 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 511 | 14 | 4 | 10 | 0.6 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCO | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL258550 | 95824 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 511 | 14 | 4 | 10 | 0.6 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCO | 10.1016/j.bmcl.2008.03.059 | |||
16114290 | 137295 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 534 | 11 | 3 | 5 | 5.3 | CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1021/jm070024h | |||
CHEMBL374992 | 137295 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 534 | 11 | 3 | 5 | 5.3 | CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1021/jm070024h | |||
11664206 | 69075 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 574 | 3 | 3 | 5 | 3.1 | C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C | 10.1021/jm2007062 | |||
CHEMBL1923626 | 69075 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 574 | 3 | 3 | 5 | 3.1 | C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C | 10.1021/jm2007062 | |||
71453489 | 211827 | None | 18 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
CHEMBL2170781 | 211827 | None | 18 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
9870965 | 64335 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 509 | 9 | 1 | 5 | 5.3 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL181092 | 64335 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 509 | 9 | 1 | 5 | 5.3 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
44434051 | 89449 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 394 | 9 | 2 | 7 | 1.8 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL237058 | 89449 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 394 | 9 | 2 | 7 | 1.8 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1 | 10.1016/j.bmcl.2007.07.099 | |||
172452277 | 196067 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 2504 | 79 | 37 | 36 | -10.1 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@]1(C)CCC/C=C\CCC[C@@](C)(C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1039/d3md00441d | |||
CHEMBL5416334 | 196067 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 2504 | 79 | 37 | 36 | -10.1 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@]1(C)CCC/C=C\CCC[C@@](C)(C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1039/d3md00441d | |||
44434053 | 146946 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 487 | 11 | 3 | 9 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1cccc(NS(C)(=O)=O)c1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL392522 | 146946 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 487 | 11 | 3 | 9 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1cccc(NS(C)(=O)=O)c1 | 10.1016/j.bmcl.2007.07.099 | |||
145988557 | 167356 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 523 | 4 | 1 | 2 | 6.9 | Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4292914 | 167356 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 523 | 4 | 1 | 2 | 6.9 | Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL2170775 | 211822 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
44434083 | 90065 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 420 | 10 | 2 | 7 | 2.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL238155 | 90065 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 420 | 10 | 2 | 7 | 2.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1 | 10.1016/j.bmcl.2007.07.099 | |||
44436884 | 91586 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 565 | 11 | 5 | 7 | 3.1 | COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1 | 10.1021/jm0704550 | |||
CHEMBL240522 | 91586 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 565 | 11 | 5 | 7 | 3.1 | COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1 | 10.1021/jm0704550 | |||
16114098 | 141698 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 534 | 11 | 3 | 5 | 5.4 | Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1021/jm070024h | |||
CHEMBL385131 | 141698 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 534 | 11 | 3 | 5 | 5.4 | Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1021/jm070024h | |||
16113246 | 94730 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 595 | 11 | 3 | 6 | 6.2 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
CHEMBL252643 | 94730 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 595 | 11 | 3 | 6 | 6.2 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
22888486 | 64339 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 552 | 9 | 2 | 6 | 5.5 | CC(=O)Nc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1 | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL181108 | 64339 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 552 | 9 | 2 | 6 | 5.5 | CC(=O)Nc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1 | 10.1016/j.bmcl.2005.02.040 | |||
71453489 | 211827 | None | 18 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/acs.jmedchem.9b02122 | |||||
CHEMBL2170781 | 211827 | None | 18 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/acs.jmedchem.9b02122 | |||||
156018539 | 177914 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 571 | 7 | 2 | 7 | 2.6 | CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4643595 | 177914 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 571 | 7 | 2 | 7 | 2.6 | CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
145949755 | 163029 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 425 | 4 | 4 | 4 | 3.3 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4174302 | 163029 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 425 | 4 | 4 | 4 | 3.3 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
156013970 | 177345 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 624 | 7 | 3 | 6 | 3.9 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4635743 | 177345 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 624 | 7 | 3 | 6 | 3.9 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1 | 10.1021/acs.jmedchem.0c00828 | |||
156018539 | 177914 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 571 | 7 | 2 | 7 | 2.6 | CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4643595 | 177914 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 571 | 7 | 2 | 7 | 2.6 | CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
69197178 | 88907 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 491 | 6 | 2 | 6 | 5.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(Cl)s2)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364336 | 88907 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 491 | 6 | 2 | 6 | 5.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(Cl)s2)cc1 | 10.6019/CHEMBL2364335 | |||
69194396 | 88958 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 471 | 7 | 2 | 6 | 4.8 | CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364387 | 88958 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 471 | 7 | 2 | 6 | 4.8 | CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1 | 10.6019/CHEMBL2364335 | |||
69195258 | 88990 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 447 | 6 | 2 | 7 | 4.0 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364419 | 88990 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 447 | 6 | 2 | 7 | 4.0 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
11604627 | 89006 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 441 | 6 | 2 | 6 | 3.9 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364433 | 89006 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 441 | 6 | 2 | 6 | 3.9 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
69197381 | 89024 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 486 | 6 | 2 | 7 | 4.4 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2cccc(C)n2)s1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364451 | 89024 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 486 | 6 | 2 | 7 | 4.4 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2cccc(C)n2)s1 | 10.6019/CHEMBL2364335 | |||
11576185 | 89031 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 458 | 6 | 2 | 7 | 3.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2nccs2)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364458 | 89031 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 458 | 6 | 2 | 7 | 3.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2nccs2)cc1 | 10.6019/CHEMBL2364335 | |||
11633856 | 89057 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 453 | 6 | 2 | 7 | 3.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ncccn2)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364483 | 89057 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 453 | 6 | 2 | 7 | 3.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ncccn2)cc1 | 10.6019/CHEMBL2364335 | |||
59007104 | 89060 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 471 | 6 | 1 | 6 | 4.8 | COc1ccc(N2C[C@H](C)N(C)[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364486 | 89060 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 471 | 6 | 1 | 6 | 4.8 | COc1ccc(N2C[C@H](C)N(C)[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2170779 | 211825 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
44579824 | 184216 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 386 | 7 | 1 | 3 | 4.2 | Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL482623 | 184216 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 386 | 7 | 1 | 3 | 4.2 | Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1 | 10.1016/j.bmcl.2008.07.120 | |||
44579883 | 186943 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 392 | 6 | 1 | 3 | 4.5 | CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL489403 | 186943 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 392 | 6 | 1 | 3 | 4.5 | CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
44579861 | 194308 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 358 | 6 | 1 | 3 | 3.9 | CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL528332 | 194308 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 358 | 6 | 1 | 3 | 3.9 | CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1 | 10.1016/j.bmcl.2008.07.120 | |||
44579906 | 192728 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 415 | 7 | 2 | 4 | 3.9 | CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@@H](C)Oc2cccc(Cl)c2)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL521612 | 192728 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 415 | 7 | 2 | 4 | 3.9 | CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@@H](C)Oc2cccc(Cl)c2)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
145992125 | 166846 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 552 | 5 | 2 | 5 | 6.2 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4283504 | 166846 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 552 | 5 | 2 | 5 | 6.2 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
156016682 | 177871 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 511 | 8 | 3 | 5 | 2.0 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4642860 | 177871 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 511 | 8 | 3 | 5 | 2.0 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL2170776 | 211823 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(C(C)(C)C)cc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
16752689 | 188475 | None | 0 | Rabbit | Functional | pEC50 | = | 6.9 | 6.9 | -5 | 3 | ChEMBL | 568 | 10 | 2 | 4 | 6.6 | COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1 | 10.1016/j.bmcl.2008.10.071 | |||
CHEMBL501315 | 188475 | None | 0 | Rabbit | Functional | pEC50 | = | 6.9 | 6.9 | -5 | 3 | ChEMBL | 568 | 10 | 2 | 4 | 6.6 | COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1 | 10.1016/j.bmcl.2008.10.071 | |||
44444557 | 154776 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 493 | 4 | 0 | 5 | 3.7 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1cccc(Br)c1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
CHEMBL399704 | 154776 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 493 | 4 | 0 | 5 | 3.7 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1cccc(Br)c1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
145957404 | 162143 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 443 | 4 | 3 | 5 | 3.1 | Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4160261 | 162143 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 443 | 4 | 3 | 5 | 3.1 | Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21 | 10.1021/acs.jmedchem.8b00322 | |||
145955250 | 162619 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 432 | 4 | 4 | 4 | 2.2 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4167776 | 162619 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 432 | 4 | 4 | 4 | 2.2 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
145950261 | 162824 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 416 | 4 | 2 | 4 | 2.6 | CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4171137 | 162824 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 416 | 4 | 2 | 4 | 2.6 | CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
156014569 | 177337 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 599 | 7 | 2 | 7 | 2.5 | CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4635694 | 177337 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 599 | 7 | 2 | 7 | 2.5 | CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1 | 10.1021/acs.jmedchem.0c00828 | |||
44452776 | 96381 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 453 | 5 | 2 | 5 | 3.4 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL261466 | 96381 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 453 | 5 | 2 | 5 | 3.4 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
69196695 | 88920 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 467 | 7 | 2 | 6 | 4.5 | COc1ccc(NS(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364349 | 88920 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 467 | 7 | 2 | 6 | 4.5 | COc1ccc(NS(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
59007058 | 88928 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 459 | 5 | 2 | 6 | 3.5 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)s1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364357 | 88928 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 459 | 5 | 2 | 6 | 3.5 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)s1 | 10.6019/CHEMBL2364335 | |||
156016682 | 177871 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 511 | 8 | 3 | 5 | 2.0 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4642860 | 177871 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 511 | 8 | 3 | 5 | 2.0 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44579842 | 184857 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 358 | 6 | 1 | 3 | 3.9 | CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL485091 | 184857 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 358 | 6 | 1 | 3 | 3.9 | CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl | 10.1016/j.bmcl.2008.07.120 | |||
145986461 | 167309 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 601 | 5 | 1 | 4 | 7.4 | Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4291926 | 167309 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 601 | 5 | 1 | 4 | 7.4 | Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
145950261 | 162824 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 416 | 4 | 2 | 4 | 2.6 | CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4171137 | 162824 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 416 | 4 | 2 | 4 | 2.6 | CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
10602593 | 112905 | None | 0 | Rat | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 542 | 12 | 2 | 4 | 4.1 | CCNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
CHEMBL330860 | 112905 | None | 0 | Rat | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 542 | 12 | 2 | 4 | 4.1 | CCNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
44391038 | 64606 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 555 | 13 | 1 | 4 | 5.9 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCCc1ccccc1)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL181627 | 64606 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 555 | 13 | 1 | 4 | 5.9 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCCc1ccccc1)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL2170783 | 211829 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@@H](N)CCCCN)C(c1ccccc1)c1ccccc1)C(N)=O | 10.1021/jm300414b | |||||
CHEMBL2170779 | 211825 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
156013970 | 177345 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 624 | 7 | 3 | 6 | 3.9 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4635743 | 177345 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 624 | 7 | 3 | 6 | 3.9 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1 | 10.1021/acs.jmedchem.0c00828 | |||
156014569 | 177337 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 599 | 7 | 2 | 7 | 2.5 | CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4635694 | 177337 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 599 | 7 | 2 | 7 | 2.5 | CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1 | 10.1021/acs.jmedchem.0c00828 | |||
56926173 | 69034 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 492 | 4 | 3 | 5 | 2.2 | CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O | 10.1021/jm2007062 | |||
CHEMBL1923501 | 69034 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 492 | 4 | 3 | 5 | 2.2 | CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O | 10.1021/jm2007062 | |||
134138625 | 148118 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 494 | 3 | 3 | 5 | 1.9 | CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O | nan | |||
CHEMBL3934561 | 148118 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 494 | 3 | 3 | 5 | 1.9 | CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O | nan | |||
155526063 | 171139 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 1174 | 34 | 16 | 14 | -2.2 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
CHEMBL4456830 | 171139 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 1174 | 34 | 16 | 14 | -2.2 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
145957404 | 162143 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 443 | 4 | 3 | 5 | 3.1 | Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4160261 | 162143 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 443 | 4 | 3 | 5 | 3.1 | Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21 | 10.1021/acs.jmedchem.8b00322 | |||
145955250 | 162619 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 432 | 4 | 4 | 4 | 2.2 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4167776 | 162619 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 432 | 4 | 4 | 4 | 2.2 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
44454060 | 155422 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 461 | 12 | 2 | 8 | 2.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1 | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL403180 | 155422 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 461 | 12 | 2 | 8 | 2.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1 | 10.1016/j.bmcl.2008.01.100 | |||
57399248 | 69066 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 556 | 4 | 3 | 5 | 3.4 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O | 10.1021/jm1012374 | |||
CHEMBL1923617 | 69066 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 556 | 4 | 3 | 5 | 3.4 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O | 10.1021/jm1012374 | |||
145949755 | 163029 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 425 | 4 | 4 | 4 | 3.3 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4174302 | 163029 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 425 | 4 | 4 | 4 | 3.3 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
44434109 | 146369 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 529 | 13 | 2 | 9 | 1.8 | CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL392076 | 146369 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 529 | 13 | 2 | 9 | 1.8 | CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O | 10.1016/j.bmcl.2007.07.099 | |||
9890375 | 98323 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 3 | ChEMBL | 458 | 5 | 3 | 3 | 3.4 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL274599 | 98323 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 3 | ChEMBL | 458 | 5 | 3 | 3 | 3.4 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL558802 | 98323 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 3 | ChEMBL | 458 | 5 | 3 | 3 | 3.4 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/j.bmc.2007.01.057 | |||
44436876 | 147107 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 580 | 11 | 4 | 7 | 4.6 | COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1 | 10.1021/jm0704550 | |||
CHEMBL392663 | 147107 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 580 | 11 | 4 | 7 | 4.6 | COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1 | 10.1021/jm0704550 | |||
9890375 | 98323 | None | 0 | Rat | Functional | pEC50 | = | 7.9 | 7.9 | -1 | 3 | ChEMBL | 458 | 5 | 3 | 3 | 3.4 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/s0960-894x(97)10199-8 | |||
CHEMBL274599 | 98323 | None | 0 | Rat | Functional | pEC50 | = | 7.9 | 7.9 | -1 | 3 | ChEMBL | 458 | 5 | 3 | 3 | 3.4 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/s0960-894x(97)10199-8 | |||
CHEMBL558802 | 98323 | None | 0 | Rat | Functional | pEC50 | = | 7.9 | 7.9 | -1 | 3 | ChEMBL | 458 | 5 | 3 | 3 | 3.4 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/s0960-894x(97)10199-8 | |||
9890375 | 98323 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 3 | ChEMBL | 458 | 5 | 3 | 3 | 3.4 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL274599 | 98323 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 3 | ChEMBL | 458 | 5 | 3 | 3 | 3.4 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL558802 | 98323 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 3 | ChEMBL | 458 | 5 | 3 | 3 | 3.4 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/j.bmc.2007.01.057 | |||
44281466 | 169485 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 436 | 8 | 2 | 4 | 2.9 | Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL442151 | 169485 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 436 | 8 | 2 | 4 | 2.9 | Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1 | 10.1016/j.bmc.2007.01.057 | |||
162672839 | 183128 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 681 | 14 | 3 | 7 | 5.9 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL4793824 | 183128 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 681 | 14 | 3 | 7 | 5.9 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
22888428 | 64371 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 508 | 9 | 2 | 4 | 4.9 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)NC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL181247 | 64371 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 508 | 9 | 2 | 4 | 4.9 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)NC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
23730227 | 147962 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 477 | 15 | 4 | 10 | 0.7 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCCO | 10.1021/jm7010595 | |||
CHEMBL393330 | 147962 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 477 | 15 | 4 | 10 | 0.7 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCCO | 10.1021/jm7010595 | |||
44450133 | 160487 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 481 | 13 | 3 | 10 | -0.7 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCS(C)(=O)=O | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL411122 | 160487 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 481 | 13 | 3 | 10 | -0.7 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCS(C)(=O)=O | 10.1016/j.bmcl.2008.03.059 | |||
44579821 | 184334 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 386 | 7 | 1 | 3 | 4.2 | Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1Cl | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL483455 | 184334 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 386 | 7 | 1 | 3 | 4.2 | Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1Cl | 10.1016/j.bmcl.2008.07.120 | |||
44579879 | 187101 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 415 | 7 | 2 | 4 | 3.9 | CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL490627 | 187101 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 415 | 7 | 2 | 4 | 3.9 | CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1 | 10.1016/j.bmcl.2008.07.120 | |||
44450071 | 96638 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 489 | 15 | 3 | 10 | 0.6 | CCOC(=O)CCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL263141 | 96638 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 489 | 15 | 3 | 10 | 0.6 | CCOC(=O)CCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2008.03.059 | |||
16113906 | 137310 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 612 | 12 | 5 | 5 | 6.3 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12 | 10.1021/jm070024h | |||
CHEMBL375102 | 137310 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 612 | 12 | 5 | 5 | 6.3 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12 | 10.1021/jm070024h | |||
44579752 | 187066 | None | 0 | Human | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 377 | 8 | 1 | 4 | 3.7 | CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL490390 | 187066 | None | 0 | Human | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 377 | 8 | 1 | 4 | 3.7 | CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
44436887 | 90993 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 563 | 11 | 5 | 6 | 3.7 | CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1 | 10.1021/jm0704550 | |||
CHEMBL239464 | 90993 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 563 | 11 | 5 | 6 | 3.7 | CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1 | 10.1021/jm0704550 | |||
44434076 | 89811 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 513 | 10 | 2 | 9 | 1.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL237717 | 89811 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 513 | 10 | 2 | 9 | 1.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21 | 10.1016/j.bmcl.2007.07.099 | |||
145952740 | 162596 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 425 | 4 | 3 | 5 | 3.0 | Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4167481 | 162596 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 425 | 4 | 3 | 5 | 3.0 | Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21 | 10.1021/acs.jmedchem.8b00322 | |||
23648250 | 79194 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 585 | 10 | 4 | 5 | 6.0 | CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1 | 10.1021/jm0704550 | |||
CHEMBL2113327 | 79194 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 585 | 10 | 4 | 5 | 6.0 | CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1 | 10.1021/jm0704550 | |||
16113577 | 84970 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 573 | 12 | 4 | 5 | 5.8 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1 | 10.1021/jm070024h | |||
CHEMBL223725 | 84970 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 573 | 12 | 4 | 5 | 5.8 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1 | 10.1021/jm070024h | |||
162657465 | 181147 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 652 | 14 | 4 | 7 | 5.1 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL4759418 | 181147 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 652 | 14 | 4 | 7 | 5.1 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
44444574 | 94073 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 484 | 5 | 1 | 7 | 3.8 | COc1cc2c(cc1N1CCNC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
CHEMBL248746 | 94073 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 484 | 5 | 1 | 7 | 3.8 | COc1cc2c(cc1N1CCNC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
145952740 | 162596 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 425 | 4 | 3 | 5 | 3.0 | Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4167481 | 162596 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 425 | 4 | 3 | 5 | 3.0 | Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21 | 10.1021/acs.jmedchem.8b00322 | |||
11532288 | 96973 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 441 | 6 | 2 | 7 | 2.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-n2cccn2)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL265950 | 96973 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 441 | 6 | 2 | 7 | 2.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-n2cccn2)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
11576186 | 155315 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 458 | 6 | 2 | 7 | 3.8 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccccn3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL402632 | 155315 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 458 | 6 | 2 | 7 | 3.8 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccccn3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.1016/j.bmcl.2007.12.021 | |||
44570964 | 183987 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 407 | 4 | 1 | 5 | 1.7 | Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL481014 | 183987 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 407 | 4 | 1 | 5 | 1.7 | Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1 | 10.1016/j.bmcl.2008.12.042 | |||
44570921 | 184061 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 413 | 4 | 1 | 4 | 2.5 | N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL481601 | 184061 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 413 | 4 | 1 | 4 | 2.5 | N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
59007073 | 88908 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 442 | 6 | 2 | 7 | 3.3 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)nc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364337 | 88908 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 442 | 6 | 2 | 7 | 3.3 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)nc1 | 10.6019/CHEMBL2364335 | |||
69197749 | 88917 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 425 | 5 | 2 | 5 | 3.8 | COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364346 | 88917 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 425 | 5 | 2 | 5 | 3.8 | COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
11682796 | 88919 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 401 | 6 | 2 | 5 | 3.3 | COc1ccc(NS(=O)(=O)/C=C/c2ccccc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364348 | 88919 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 401 | 6 | 2 | 5 | 3.3 | COc1ccc(NS(=O)(=O)/C=C/c2ccccc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
69198460 | 88931 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 443 | 5 | 2 | 5 | 4.0 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.6019/CHEMBL2364335 | |||
CHEMBL2364360 | 88931 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 443 | 5 | 2 | 5 | 4.0 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.6019/CHEMBL2364335 | |||
69198360 | 88939 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 466 | 6 | 2 | 6 | 4.1 | COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364368 | 88939 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 466 | 6 | 2 | 6 | 4.1 | COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
11683967 | 88951 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 457 | 6 | 2 | 6 | 4.4 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cccs2)c1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364380 | 88951 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 457 | 6 | 2 | 6 | 4.4 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cccs2)c1 | 10.6019/CHEMBL2364335 | |||
69195261 | 88959 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 485 | 7 | 2 | 6 | 5.2 | CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364388 | 88959 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 485 | 7 | 2 | 6 | 5.2 | CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1 | 10.6019/CHEMBL2364335 | |||
11516766 | 88963 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 395 | 4 | 2 | 4 | 3.8 | C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364392 | 88963 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 395 | 4 | 2 | 4 | 3.8 | C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
11525161 | 89020 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 447 | 5 | 2 | 5 | 4.2 | C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)c(F)c3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364447 | 89020 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 447 | 5 | 2 | 5 | 4.2 | C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)c(F)c3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
69194533 | 89050 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 477 | 6 | 2 | 6 | 4.2 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(F)c(-c2ccco2)cc1F | 10.6019/CHEMBL2364335 | |||
CHEMBL2364476 | 89050 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 477 | 6 | 2 | 6 | 4.2 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(F)c(-c2ccco2)cc1F | 10.6019/CHEMBL2364335 | |||
69197165 | 89062 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 427 | 5 | 3 | 6 | 3.6 | C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364488 | 89062 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 427 | 5 | 3 | 6 | 3.6 | C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
44579777 | 187090 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 372 | 7 | 1 | 3 | 3.9 | CC(Oc1ccccc1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL490601 | 187090 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 372 | 7 | 1 | 3 | 3.9 | CC(Oc1ccccc1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
44454432 | 155348 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 461 | 12 | 2 | 8 | 2.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL402808 | 155348 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 461 | 12 | 2 | 8 | 2.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.100 | |||
44434112 | 168963 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 525 | 11 | 2 | 10 | 1.8 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL438154 | 168963 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 525 | 11 | 2 | 10 | 1.8 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1 | 10.1016/j.bmcl.2007.07.099 | |||
44579908 | 186980 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 372 | 7 | 1 | 3 | 3.9 | C[C@@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL489610 | 186980 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 372 | 7 | 1 | 3 | 3.9 | C[C@@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
145954311 | 162581 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 404 | 6 | 3 | 3 | 2.9 | Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4167267 | 162581 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 404 | 6 | 3 | 3 | 2.9 | Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
44434124 | 88692 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 343 | 8 | 2 | 8 | 0.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC#N)n1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL235817 | 88692 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 343 | 8 | 2 | 8 | 0.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC#N)n1 | 10.1016/j.bmcl.2007.07.099 | |||
162659161 | 181497 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 642 | 14 | 4 | 7 | 5.1 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL4763471 | 181497 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 642 | 14 | 4 | 7 | 5.1 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
44444556 | 94455 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 471 | 6 | 0 | 5 | 4.4 | CCOc1ccc(CC(=O)N2CCc3cc(OC)c(N4C[C@H](C)N(C)[C@H](C)C4)cc32)cc1Cl | 10.1016/j.bmcl.2007.09.067 | |||
CHEMBL250973 | 94455 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 471 | 6 | 0 | 5 | 4.4 | CCOc1ccc(CC(=O)N2CCc3cc(OC)c(N4C[C@H](C)N(C)[C@H](C)C4)cc32)cc1Cl | 10.1016/j.bmcl.2007.09.067 | |||
145950963 | 162901 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 430 | 4 | 2 | 4 | 3.0 | CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4172411 | 162901 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 430 | 4 | 2 | 4 | 3.0 | CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
145952396 | 163098 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 434 | 9 | 3 | 5 | 2.3 | COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4175534 | 163098 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 434 | 9 | 3 | 5 | 2.3 | COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C | 10.1021/acs.jmedchem.8b00322 | |||
156011695 | 177460 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 585 | 8 | 2 | 7 | 2.2 | O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4637585 | 177460 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 585 | 8 | 2 | 7 | 2.2 | O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1 | 10.1021/acs.jmedchem.0c00828 | |||
44452887 | 159672 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 451 | 6 | 2 | 5 | 4.4 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccccc2)c1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL410282 | 159672 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 451 | 6 | 2 | 5 | 4.4 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccccc2)c1 | 10.1016/j.bmcl.2007.12.021 | |||
46882522 | 5714 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -39 | 2 | ChEMBL | 440 | 7 | 2 | 5 | 3.6 | CC(C)Oc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1 | 10.1016/j.bmcl.2009.09.027 | |||
CHEMBL1078208 | 5714 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -39 | 2 | ChEMBL | 440 | 7 | 2 | 5 | 3.6 | CC(C)Oc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1 | 10.1016/j.bmcl.2009.09.027 | |||
69195349 | 88942 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 453 | 5 | 2 | 5 | 3.4 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Br)c1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364371 | 88942 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 453 | 5 | 2 | 5 | 3.4 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Br)c1 | 10.6019/CHEMBL2364335 | |||
69198352 | 89063 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 443 | 6 | 2 | 6 | 4.0 | COc1ccc(N2CCN[C@@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364489 | 89063 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 443 | 6 | 2 | 6 | 4.0 | COc1ccc(N2CCN[C@@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1 | 10.6019/CHEMBL2364335 | |||
44446188 | 155481 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 611 | 11 | 3 | 7 | 6.6 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
CHEMBL403542 | 155481 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 611 | 11 | 3 | 7 | 6.6 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
145954311 | 162581 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 404 | 6 | 3 | 3 | 2.9 | Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4167267 | 162581 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 404 | 6 | 3 | 3 | 2.9 | Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
46882521 | 5713 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -158 | 2 | ChEMBL | 458 | 6 | 2 | 4 | 4.5 | O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccc2)cc1 | 10.1016/j.bmcl.2009.09.027 | |||
CHEMBL1078207 | 5713 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -158 | 2 | ChEMBL | 458 | 6 | 2 | 4 | 4.5 | O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccc2)cc1 | 10.1016/j.bmcl.2009.09.027 | |||
44445620 | 154768 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 571 | 11 | 2 | 6 | 6.1 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1 | 10.1021/jm701292s | |||
CHEMBL399651 | 154768 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 571 | 11 | 2 | 6 | 6.1 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1 | 10.1021/jm701292s | |||
22862453 | 98512 | None | 0 | Rat | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 490 | 5 | 4 | 5 | 2.8 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(O)c1ccccc1O2 | 10.1016/s0960-894x(97)10199-8 | |||
CHEMBL275795 | 98512 | None | 0 | Rat | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 490 | 5 | 4 | 5 | 2.8 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(O)c1ccccc1O2 | 10.1016/s0960-894x(97)10199-8 | |||
10675061 | 96596 | None | 0 | Rat | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 598 | 13 | 2 | 5 | 4.3 | CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1 | 10.1021/jm980197u | |||
CHEMBL262889 | 96596 | None | 0 | Rat | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 598 | 13 | 2 | 5 | 4.3 | CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1 | 10.1021/jm980197u | |||
10026738 | 162864 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 449 | 7 | 2 | 4 | 2.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL417182 | 162864 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 449 | 7 | 2 | 4 | 2.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL557206 | 162864 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 449 | 7 | 2 | 4 | 2.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/j.bmc.2007.01.057 | |||
56926464 | 69061 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 508 | 4 | 3 | 5 | 2.5 | CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O | nan | |||
CHEMBL1923612 | 69061 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 508 | 4 | 3 | 5 | 2.5 | CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O | nan | |||
155540883 | 173060 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 4548 | 115 | 75 | 66 | -23.9 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
CHEMBL4517399 | 173060 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 4548 | 115 | 75 | 66 | -23.9 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
10210658 | 10328 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 593 | 13 | 5 | 5 | 3.6 | NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1162064 | 10328 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 593 | 13 | 5 | 5 | 3.6 | NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1 | 10.1016/j.bmc.2007.01.057 | |||
145952396 | 163098 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 434 | 9 | 3 | 5 | 2.3 | COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4175534 | 163098 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 434 | 9 | 3 | 5 | 2.3 | COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL2170784 | 211830 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
134139080 | 147771 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 508 | 4 | 4 | 5 | 2.4 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O | nan | |||
CHEMBL3931856 | 147771 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 508 | 4 | 4 | 5 | 2.4 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O | nan | |||
156011695 | 177460 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 585 | 8 | 2 | 7 | 2.2 | O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4637585 | 177460 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 585 | 8 | 2 | 7 | 2.2 | O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL2170697 | 211816 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
44434080 | 89945 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 422 | 11 | 2 | 7 | 2.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1 | 10.1016/j.bmcl.2007.07.099 | |||
44434080 | 89945 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 422 | 11 | 2 | 7 | 2.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1 | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL237933 | 89945 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 422 | 11 | 2 | 7 | 2.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL237933 | 89945 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 422 | 11 | 2 | 7 | 2.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1 | 10.1016/j.bmcl.2008.01.100 | |||
10210658 | 10328 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 593 | 13 | 5 | 5 | 3.6 | NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1162064 | 10328 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 593 | 13 | 5 | 5 | 3.6 | NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1 | 10.1016/j.bmc.2007.01.057 | |||
10026738 | 162864 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 449 | 7 | 2 | 4 | 2.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL417182 | 162864 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 449 | 7 | 2 | 4 | 2.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL557206 | 162864 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 449 | 7 | 2 | 4 | 2.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/j.bmc.2007.01.057 | |||
10530983 | 168488 | None | 0 | Rat | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 564 | 11 | 2 | 4 | 4.0 | CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
CHEMBL434609 | 168488 | None | 0 | Rat | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 564 | 11 | 2 | 4 | 4.0 | CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
44391003 | 123388 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 531 | 10 | 1 | 4 | 5.4 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1F)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL361612 | 123388 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 531 | 10 | 1 | 4 | 5.4 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1F)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL2170780 | 211826 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
145950963 | 162901 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 430 | 4 | 2 | 4 | 3.0 | CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4172411 | 162901 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 430 | 4 | 2 | 4 | 3.0 | CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
127047409 | 139718 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 888 | 24 | 8 | 10 | 5.2 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3797639 | 139718 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 888 | 24 | 8 | 10 | 5.2 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
10745533 | 140207 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 564 | 12 | 2 | 5 | 4.0 | CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL380096 | 140207 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 564 | 12 | 2 | 5 | 4.0 | CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||
44437971 | 204977 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 485 | 7 | 2 | 4 | 3.9 | CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL611489 | 204977 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 485 | 7 | 2 | 4 | 3.9 | CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F | 10.1016/j.bmc.2007.01.057 | |||
16113693 | 138103 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 589 | 12 | 4 | 6 | 5.6 | COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1 | 10.1021/jm070024h | |||
CHEMBL376471 | 138103 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 589 | 12 | 4 | 6 | 5.6 | COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1 | 10.1021/jm070024h | |||
11692516 | 69070 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 554 | 3 | 3 | 5 | 3.1 | C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1 | 10.1021/jm2007062 | |||
CHEMBL1923621 | 69070 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 554 | 3 | 3 | 5 | 3.1 | C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1 | 10.1021/jm2007062 | |||
155557019 | 174691 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 1598 | 47 | 22 | 19 | -3.2 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
CHEMBL4556887 | 174691 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 1598 | 47 | 22 | 19 | -3.2 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
9810101 | 99303 | None | 14 | Rat | Functional | pEC50 | = | 7.8 | 7.8 | -5 | 2 | ChEMBL | 528 | 11 | 2 | 4 | 3.7 | CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
CHEMBL281764 | 99303 | None | 14 | Rat | Functional | pEC50 | = | 7.8 | 7.8 | -5 | 2 | ChEMBL | 528 | 11 | 2 | 4 | 3.7 | CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
10745533 | 140207 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 564 | 12 | 2 | 5 | 4.0 | CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL380096 | 140207 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 564 | 12 | 2 | 5 | 4.0 | CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||
44437971 | 204977 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 485 | 7 | 2 | 4 | 3.9 | CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL611489 | 204977 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 485 | 7 | 2 | 4 | 3.9 | CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F | 10.1016/j.bmc.2007.01.057 | |||
44579909 | 187009 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 386 | 7 | 1 | 3 | 4.2 | Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL489819 | 187009 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 386 | 7 | 1 | 3 | 4.2 | Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1 | 10.1016/j.bmcl.2008.07.120 | |||
44436882 | 146104 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 524 | 10 | 4 | 6 | 4.2 | O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1 | 10.1021/jm0704550 | |||
CHEMBL391859 | 146104 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 524 | 10 | 4 | 6 | 4.2 | O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1 | 10.1021/jm0704550 | |||
CHEMBL2170698 | 211817 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
44434122 | 89545 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 385 | 11 | 2 | 8 | 1.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCCC#N)n1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL237302 | 89545 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 385 | 11 | 2 | 8 | 1.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCCC#N)n1 | 10.1016/j.bmcl.2007.07.099 | |||
145992142 | 166867 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 475 | 4 | 2 | 3 | 5.9 | Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4283858 | 166867 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 475 | 4 | 2 | 3 | 5.9 | Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL3578006 | 214220 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)O | 10.1021/jm501702q | |||||
145953016 | 162682 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 430 | 5 | 2 | 4 | 3.2 | CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4168863 | 162682 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 430 | 5 | 2 | 4 | 3.2 | CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1 | 10.1021/acs.jmedchem.8b00322 | |||
44454304 | 97656 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 464 | 12 | 2 | 10 | 1.7 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1 | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL270876 | 97656 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 464 | 12 | 2 | 10 | 1.7 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1 | 10.1016/j.bmcl.2008.01.100 | |||
44454092 | 97702 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 459 | 11 | 2 | 8 | 3.0 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1 | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL271082 | 97702 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 459 | 11 | 2 | 8 | 3.0 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1 | 10.1016/j.bmcl.2008.01.100 | |||
44454338 | 97888 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 463 | 12 | 2 | 9 | 2.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1 | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL272085 | 97888 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 463 | 12 | 2 | 9 | 2.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1 | 10.1016/j.bmcl.2008.01.100 | |||
22867310 | 30049 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 474 | 5 | 4 | 4 | 2.8 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2O | 10.1016/s0960-894x(97)10199-8 | |||
CHEMBL13891 | 30049 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 474 | 5 | 4 | 4 | 2.8 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2O | 10.1016/s0960-894x(97)10199-8 | |||
162653802 | 180637 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 656 | 15 | 4 | 7 | 5.5 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL4753592 | 180637 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 656 | 15 | 4 | 7 | 5.5 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
44436886 | 162049 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 595 | 12 | 5 | 8 | 3.2 | COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1 | 10.1021/jm0704550 | |||
CHEMBL415674 | 162049 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 595 | 12 | 5 | 8 | 3.2 | COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1 | 10.1021/jm0704550 | |||
9987037 | 12036 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 564 | 12 | 2 | 7 | 2.5 | CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 | 10.1016/s0960-894x(01)00324-9 | |||
CHEMBL1183385 | 12036 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 564 | 12 | 2 | 7 | 2.5 | CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 | 10.1016/s0960-894x(01)00324-9 | |||
CHEMBL294324 | 12036 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 564 | 12 | 2 | 7 | 2.5 | CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 | 10.1016/s0960-894x(01)00324-9 | |||
44391008 | 64888 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 481 | 9 | 1 | 5 | 4.6 | CCN(CC)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL182137 | 64888 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 481 | 9 | 1 | 5 | 4.6 | CCN(CC)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C | 10.1016/j.bmcl.2005.02.040 | |||
22888379 | 168416 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 584 | 12 | 2 | 5 | 4.8 | CC(=O)NC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1 | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL434152 | 168416 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 584 | 12 | 2 | 5 | 4.8 | CC(=O)NC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1 | 10.1016/j.bmcl.2005.02.040 | |||
44444564 | 94525 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 478 | 5 | 1 | 6 | 3.7 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1cccc(-c3ccccn3)c1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
CHEMBL251366 | 94525 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 478 | 5 | 1 | 6 | 3.7 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1cccc(-c3ccccn3)c1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
145961213 | 162257 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 446 | 4 | 3 | 4 | 2.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4162174 | 162257 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 446 | 4 | 3 | 4 | 2.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
145953016 | 162682 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 430 | 5 | 2 | 4 | 3.2 | CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4168863 | 162682 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 430 | 5 | 2 | 4 | 3.2 | CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1 | 10.1021/acs.jmedchem.8b00322 | |||
145949595 | 162819 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 404 | 6 | 3 | 3 | 2.9 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4171040 | 162819 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 404 | 6 | 3 | 3 | 2.9 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
145974293 | 163119 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 432 | 4 | 2 | 5 | 2.0 | CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4175823 | 163119 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 432 | 4 | 2 | 5 | 2.0 | CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
44452929 | 97596 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 441 | 6 | 2 | 6 | 3.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccco2)c1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL270573 | 97596 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 441 | 6 | 2 | 6 | 3.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccco2)c1 | 10.1016/j.bmcl.2007.12.021 | |||
46882396 | 5846 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 3 | 2 | ChEMBL | 452 | 8 | 2 | 4 | 4.5 | CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc(C)[nH]2)CC3)cc1 | 10.1016/j.bmcl.2009.09.027 | |||
CHEMBL1079187 | 5846 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 3 | 2 | ChEMBL | 452 | 8 | 2 | 4 | 4.5 | CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc(C)[nH]2)CC3)cc1 | 10.1016/j.bmcl.2009.09.027 | |||
44570698 | 184064 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 456 | 5 | 2 | 5 | 2.0 | N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL481619 | 184064 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 456 | 5 | 2 | 5 | 2.0 | N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
24969292 | 88911 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 444 | 5 | 2 | 6 | 3.8 | Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccn3)cc2F)o1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364340 | 88911 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 444 | 5 | 2 | 6 | 3.8 | Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccn3)cc2F)o1 | 10.6019/CHEMBL2364335 | |||
69194665 | 88944 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 476 | 6 | 2 | 7 | 3.9 | COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364373 | 88944 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 476 | 6 | 2 | 7 | 3.9 | COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1 | 10.6019/CHEMBL2364335 | |||
11524465 | 88964 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 413 | 4 | 2 | 4 | 4.0 | C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc(Cl)c3Cl)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364393 | 88964 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 413 | 4 | 2 | 4 | 4.0 | C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc(Cl)c3Cl)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
11576404 | 88975 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 469 | 6 | 2 | 5 | 4.5 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364404 | 88975 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 469 | 6 | 2 | 5 | 4.5 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
69194865 | 88994 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 409 | 4 | 2 | 4 | 4.1 | Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2ccccc12 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364422 | 88994 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 409 | 4 | 2 | 4 | 4.1 | Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2ccccc12 | 10.6019/CHEMBL2364335 | |||
11712498 | 89008 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 469 | 6 | 2 | 5 | 4.5 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2F)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364435 | 89008 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 469 | 6 | 2 | 5 | 4.5 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2F)cc1 | 10.6019/CHEMBL2364335 | |||
69195296 | 89013 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 463 | 5 | 2 | 5 | 4.7 | C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3F)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364440 | 89013 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 463 | 5 | 2 | 5 | 4.7 | C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3F)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
11518242 | 89016 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 459 | 5 | 2 | 5 | 4.9 | Cc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F | 10.6019/CHEMBL2364335 | |||
CHEMBL2364443 | 89016 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 459 | 5 | 2 | 5 | 4.9 | Cc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F | 10.6019/CHEMBL2364335 | |||
69197366 | 89021 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 463 | 5 | 2 | 5 | 4.7 | C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3Cl)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364448 | 89021 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 463 | 5 | 2 | 5 | 4.7 | C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3Cl)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
11503413 | 89038 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 454 | 6 | 2 | 6 | 3.7 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccn2C)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364465 | 89038 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 454 | 6 | 2 | 6 | 3.7 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccn2C)cc1 | 10.6019/CHEMBL2364335 | |||
11647900 | 89044 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 441 | 6 | 2 | 6 | 3.9 | COc1cc(-c2ccco2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364470 | 89044 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 441 | 6 | 2 | 6 | 3.9 | COc1cc(-c2ccco2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1 | 10.6019/CHEMBL2364335 | |||
11669734 | 89045 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 457 | 6 | 2 | 6 | 4.4 | COc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364471 | 89045 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 457 | 6 | 2 | 6 | 4.4 | COc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1 | 10.6019/CHEMBL2364335 | |||
44391007 | 64887 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 480 | 9 | 1 | 4 | 4.1 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)N(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL182136 | 64887 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 480 | 9 | 1 | 4 | 4.1 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)N(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
145994050 | 167441 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 615 | 6 | 1 | 6 | 7.1 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4294493 | 167441 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 615 | 6 | 1 | 6 | 7.1 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
156016392 | 177751 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 476 | 7 | 3 | 5 | 1.8 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4641386 | 177751 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 476 | 7 | 3 | 5 | 1.8 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL3578006 | 214220 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)O | 10.1021/jm501702q | |||||
25098836 | 191567 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 386 | 7 | 1 | 3 | 4.2 | Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL519322 | 191567 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 386 | 7 | 1 | 3 | 4.2 | Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1 | 10.1016/j.bmcl.2008.07.120 | |||
145957574 | 162395 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 57 | 2 | ChEMBL | 390 | 6 | 3 | 3 | 2.3 | CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4164328 | 162395 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 57 | 2 | ChEMBL | 390 | 6 | 3 | 3 | 2.3 | CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
44411745 | 10310 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 481 | 7 | 2 | 4 | 2.9 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161827 | 10310 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 481 | 7 | 2 | 4 | 2.9 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
10626337 | 101279 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 543 | 9 | 5 | 5 | 2.8 | CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL295984 | 101279 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 543 | 9 | 5 | 5 | 2.8 | CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O | 10.1016/j.bmc.2007.01.057 | |||
156013219 | 177594 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 60 | 3 | ChEMBL | 404 | 6 | 3 | 3 | 2.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4639379 | 177594 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 60 | 3 | ChEMBL | 404 | 6 | 3 | 3 | 2.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
22888352 | 63958 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 537 | 11 | 1 | 6 | 4.9 | CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL180659 | 63958 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 537 | 11 | 1 | 6 | 4.9 | CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
22888352 | 63958 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 537 | 11 | 1 | 6 | 4.9 | CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL180659 | 63958 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 537 | 11 | 1 | 6 | 4.9 | CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
10649999 | 17113 | None | 0 | Rat | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 534 | 11 | 2 | 5 | 3.8 | CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
CHEMBL125498 | 17113 | None | 0 | Rat | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 534 | 11 | 2 | 5 | 3.8 | CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
156015928 | 177686 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 512 | 8 | 3 | 6 | 1.4 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4640615 | 177686 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 512 | 8 | 3 | 6 | 1.4 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
156012445 | 177440 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 499 | 8 | 3 | 7 | 0.4 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4637284 | 177440 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 499 | 8 | 3 | 7 | 0.4 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44411634 | 10307 | None | 1 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 508 | 5 | 3 | 5 | 2.3 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161824 | 10307 | None | 1 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 508 | 5 | 3 | 5 | 2.3 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
44411634 | 10307 | None | 1 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 508 | 5 | 3 | 5 | 2.3 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161824 | 10307 | None | 1 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 508 | 5 | 3 | 5 | 2.3 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
44390986 | 64690 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 557 | 12 | 1 | 5 | 5.2 | COc1ccccc1CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL181832 | 64690 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 557 | 12 | 1 | 5 | 5.2 | COc1ccccc1CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL2170695 | 211814 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
156011766 | 177413 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 569 | 6 | 2 | 7 | 2.2 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4636780 | 177413 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 569 | 6 | 2 | 7 | 2.2 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1 | 10.1021/acs.jmedchem.0c00828 | |||
44281449 | 113457 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 559 | 12 | 4 | 7 | 1.4 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL33182 | 113457 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 559 | 12 | 4 | 7 | 1.4 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1 | 10.1016/j.bmc.2007.01.057 | |||
44281449 | 113457 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 559 | 12 | 4 | 7 | 1.4 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL33182 | 113457 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 559 | 12 | 4 | 7 | 1.4 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1 | 10.1016/j.bmc.2007.01.057 | |||
23648249 | 79193 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 557 | 9 | 4 | 5 | 5.4 | O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1 | 10.1021/jm0704550 | |||
CHEMBL2113326 | 79193 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 557 | 9 | 4 | 5 | 5.4 | O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1 | 10.1021/jm0704550 | |||
10166594 | 64657 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 563 | 8 | 1 | 5 | 6.6 | CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C(F)(F)F)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL181786 | 64657 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 563 | 8 | 1 | 5 | 6.6 | CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C(F)(F)F)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
44391010 | 64895 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 541 | 9 | 1 | 6 | 6.3 | CSc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1 | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL182158 | 64895 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 541 | 9 | 1 | 6 | 6.3 | CSc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1 | 10.1016/j.bmcl.2005.02.040 | |||
172441221 | 195372 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 2503 | 79 | 37 | 39 | -12.8 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CCCCn2cc(nn2)C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1039/d3md00441d | |||
CHEMBL5402226 | 195372 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 2503 | 79 | 37 | 39 | -12.8 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CCCCn2cc(nn2)C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1039/d3md00441d | |||
23648244 | 92048 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 601 | 11 | 4 | 6 | 5.5 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1 | 10.1021/jm0704550 | |||
CHEMBL241775 | 92048 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 601 | 11 | 4 | 6 | 5.5 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1 | 10.1021/jm0704550 | |||
155557019 | 174691 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 1598 | 47 | 22 | 19 | -3.2 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
CHEMBL4556887 | 174691 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 1598 | 47 | 22 | 19 | -3.2 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
44444565 | 94553 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 474 | 5 | 1 | 8 | 3.4 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccon3)s1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
CHEMBL251573 | 94553 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 474 | 5 | 1 | 8 | 3.4 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccon3)s1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
145957075 | 162373 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 447 | 4 | 4 | 4 | 3.2 | Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4164040 | 162373 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 447 | 4 | 4 | 4 | 3.2 | Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
44411745 | 10310 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 481 | 7 | 2 | 4 | 2.9 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161827 | 10310 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 481 | 7 | 2 | 4 | 2.9 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
156013684 | 177370 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 571 | 7 | 3 | 7 | 2.6 | Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4636178 | 177370 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 571 | 7 | 3 | 7 | 2.6 | Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
156011766 | 177413 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 569 | 6 | 2 | 7 | 2.2 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4636780 | 177413 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 569 | 6 | 2 | 7 | 2.2 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1 | 10.1021/acs.jmedchem.0c00828 | |||
11539642 | 97981 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 448 | 6 | 2 | 8 | 3.4 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)s1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL272540 | 97981 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 448 | 6 | 2 | 8 | 3.4 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)s1 | 10.1016/j.bmcl.2007.12.021 | |||
44570702 | 183942 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 463 | 4 | 1 | 5 | 3.1 | Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2F)o1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL480639 | 183942 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 463 | 4 | 1 | 5 | 3.1 | Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2F)o1 | 10.1016/j.bmcl.2008.12.042 | |||
11683968 | 88950 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 457 | 6 | 2 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364379 | 88950 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 457 | 6 | 2 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
69197883 | 88973 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 475 | 6 | 2 | 6 | 4.6 | COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2F)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364402 | 88973 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 475 | 6 | 2 | 6 | 4.6 | COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2F)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
69195597 | 88986 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 491 | 6 | 2 | 6 | 5.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2Cl)s1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364415 | 88986 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 491 | 6 | 2 | 6 | 5.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2Cl)s1 | 10.6019/CHEMBL2364335 | |||
59007081 | 89000 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 485 | 6 | 2 | 5 | 5.0 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(Cl)c2)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364428 | 89000 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 485 | 6 | 2 | 5 | 5.0 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(Cl)c2)cc1 | 10.6019/CHEMBL2364335 | |||
11648834 | 89055 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 489 | 6 | 2 | 6 | 4.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1F | 10.6019/CHEMBL2364335 | |||
CHEMBL2364481 | 89055 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 489 | 6 | 2 | 6 | 4.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1F | 10.6019/CHEMBL2364335 | |||
44411753 | 10312 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 449 | 7 | 2 | 4 | 3.2 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161829 | 10312 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 449 | 7 | 2 | 4 | 3.2 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
44411753 | 10312 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 449 | 7 | 2 | 4 | 3.2 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161829 | 10312 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 449 | 7 | 2 | 4 | 3.2 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
10415000 | 168170 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 543 | 11 | 3 | 6 | 2.7 | CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL432461 | 168170 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 543 | 11 | 3 | 6 | 2.7 | CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1 | 10.1016/j.bmc.2007.01.057 | |||
71453489 | 211827 | None | 18 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
CHEMBL2170781 | 211827 | None | 18 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
156013684 | 177370 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 571 | 7 | 3 | 7 | 2.6 | Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4636178 | 177370 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 571 | 7 | 3 | 7 | 2.6 | Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
10415000 | 168170 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 543 | 11 | 3 | 6 | 2.7 | CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL432461 | 168170 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 543 | 11 | 3 | 6 | 2.7 | CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1 | 10.1016/j.bmc.2007.01.057 | |||
156019457 | 178047 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 515 | 8 | 3 | 7 | 0.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4645625 | 178047 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 515 | 8 | 3 | 7 | 0.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44449922 | 96274 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 615 | 17 | 3 | 11 | 1.0 | CN(CCc1cccc(S(=O)(=O)CCO)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL260849 | 96274 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 615 | 17 | 3 | 11 | 1.0 | CN(CCc1cccc(S(=O)(=O)CCO)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2008.03.059 | |||
44269019 | 98279 | None | 0 | Rat | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 474 | 5 | 3 | 4 | 3.3 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc3O2)C1 | 10.1016/s0960-894x(97)10199-8 | |||
CHEMBL274340 | 98279 | None | 0 | Rat | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 474 | 5 | 3 | 4 | 3.3 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc3O2)C1 | 10.1016/s0960-894x(97)10199-8 | |||
44579840 | 184855 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 406 | 7 | 1 | 3 | 4.5 | CC(Oc1cccc(Cl)c1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL485090 | 184855 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 406 | 7 | 1 | 3 | 4.5 | CC(Oc1cccc(Cl)c1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
44579907 | 187154 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 415 | 7 | 2 | 4 | 3.9 | CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL491044 | 187154 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 415 | 7 | 2 | 4 | 3.9 | CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
44579805 | 187172 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 372 | 7 | 1 | 3 | 3.9 | CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL491221 | 187172 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 372 | 7 | 1 | 3 | 3.9 | CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
44434113 | 88683 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 452 | 10 | 2 | 9 | 1.5 | COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL235793 | 88683 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 452 | 10 | 2 | 9 | 1.5 | COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2007.07.099 | |||
127048060 | 139948 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 789 | 20 | 6 | 10 | 5.4 | COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3799222 | 139948 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 789 | 20 | 6 | 10 | 5.4 | COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
57399248 | 69066 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 556 | 4 | 3 | 5 | 3.4 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O | 10.1021/jm2007062 | |||
CHEMBL1923617 | 69066 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 556 | 4 | 3 | 5 | 3.4 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O | 10.1021/jm2007062 | |||
44268965 | 24070 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 472 | 5 | 3 | 4 | 3.0 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2=O)C1 | 10.1016/s0960-894x(97)10199-8 | |||
CHEMBL13383 | 24070 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 472 | 5 | 3 | 4 | 3.0 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2=O)C1 | 10.1016/s0960-894x(97)10199-8 | |||
10675800 | 113858 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 654 | 11 | 2 | 4 | 4.3 | CNC(=O)[C@@H](Cc1ccc(I)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
CHEMBL332414 | 113858 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 654 | 11 | 2 | 4 | 4.3 | CNC(=O)[C@@H](Cc1ccc(I)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
44391002 | 123977 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 507 | 10 | 1 | 4 | 5.4 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL362798 | 123977 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 507 | 10 | 1 | 4 | 5.4 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
44579857 | 187030 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 415 | 7 | 2 | 4 | 3.9 | CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL490009 | 187030 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 415 | 7 | 2 | 4 | 3.9 | CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1 | 10.1016/j.bmcl.2008.07.120 | |||
44434018 | 88526 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 399 | 8 | 3 | 8 | 0.9 | COC(=O)CCn1nnnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL235012 | 88526 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 399 | 8 | 3 | 8 | 0.9 | COC(=O)CCn1nnnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2007.07.099 | |||
44579641 | 187003 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 370 | 7 | 1 | 4 | 4.0 | CSc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL489794 | 187003 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 370 | 7 | 1 | 4 | 4.0 | CSc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1 | 10.1016/j.bmcl.2008.07.120 | |||
44579996 | 187242 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 367 | 7 | 2 | 4 | 2.8 | CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)COc2ccccc2)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL491835 | 187242 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 367 | 7 | 2 | 4 | 2.8 | CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)COc2ccccc2)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
44579919 | 191458 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 444 | 9 | 1 | 4 | 5.3 | CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(-c2ccccc2)c1OC | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL519196 | 191458 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 444 | 9 | 1 | 4 | 5.3 | CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(-c2ccccc2)c1OC | 10.1016/j.bmcl.2008.07.120 | |||
44454092 | 97702 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 459 | 11 | 2 | 8 | 3.0 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1 | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL271082 | 97702 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 459 | 11 | 2 | 8 | 3.0 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1 | 10.1016/j.bmcl.2008.01.100 | |||
44450070 | 158743 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 461 | 14 | 4 | 9 | 0.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(=O)O | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL409258 | 158743 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 461 | 14 | 4 | 9 | 0.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(=O)O | 10.1016/j.bmcl.2008.03.059 | |||
156016392 | 177751 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 476 | 7 | 3 | 5 | 1.8 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4641386 | 177751 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 476 | 7 | 3 | 5 | 1.8 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
145961213 | 162257 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 446 | 4 | 3 | 4 | 2.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4162174 | 162257 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 446 | 4 | 3 | 4 | 2.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
145949595 | 162819 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 404 | 6 | 3 | 3 | 2.9 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4171040 | 162819 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 404 | 6 | 3 | 3 | 2.9 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
145974293 | 163119 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 432 | 4 | 2 | 5 | 2.0 | CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4175823 | 163119 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 432 | 4 | 2 | 5 | 2.0 | CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
44390905 | 64478 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 544 | 10 | 1 | 6 | 3.4 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)N(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL181337 | 64478 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 544 | 10 | 1 | 6 | 3.4 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)N(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
44391040 | 64482 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 577 | 10 | 1 | 6 | 5.0 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)c1ccccc1)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL181352 | 64482 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 577 | 10 | 1 | 6 | 5.0 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)c1ccccc1)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
10579444 | 114307 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 598 | 13 | 2 | 5 | 4.3 | CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1cccc2ccccc12)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1 | 10.1021/jm980197u | |||
CHEMBL332987 | 114307 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 598 | 13 | 2 | 5 | 4.3 | CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1cccc2ccccc12)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1 | 10.1021/jm980197u | |||
162645413 | 179832 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 677 | 14 | 3 | 7 | 6.0 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL4744051 | 179832 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 677 | 14 | 3 | 7 | 6.0 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
44293091 | 188292 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 433 | 6 | 2 | 3 | 3.3 | CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL49884 | 188292 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 433 | 6 | 2 | 3 | 3.3 | CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/j.bmc.2007.01.057 | |||
16114011 | 138225 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 563 | 10 | 4 | 5 | 5.4 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1 | 10.1021/jm070024h | |||
CHEMBL376736 | 138225 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 563 | 10 | 4 | 5 | 5.4 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1 | 10.1021/jm070024h | |||
145981343 | 166805 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 669 | 6 | 1 | 6 | 7.6 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4282719 | 166805 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 669 | 6 | 1 | 6 | 7.6 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
44391048 | 62968 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 467 | 8 | 2 | 5 | 4.2 | CC(C)NCCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL178502 | 62968 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 467 | 8 | 2 | 5 | 4.2 | CC(C)NCCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C | 10.1016/j.bmcl.2005.02.040 | |||
44454399 | 155229 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 447 | 11 | 2 | 8 | 2.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1 | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL402086 | 155229 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 447 | 11 | 2 | 8 | 2.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1 | 10.1016/j.bmcl.2008.01.100 | |||
44293091 | 188292 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 433 | 6 | 2 | 3 | 3.3 | CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL49884 | 188292 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 433 | 6 | 2 | 3 | 3.3 | CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/j.bmc.2007.01.057 | |||
155540883 | 173060 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 4548 | 115 | 75 | 66 | -23.9 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
CHEMBL4517399 | 173060 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 4548 | 115 | 75 | 66 | -23.9 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
44579801 | 187267 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 372 | 7 | 1 | 3 | 3.9 | CC(Oc1ccccc1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL492028 | 187267 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 372 | 7 | 1 | 3 | 3.9 | CC(Oc1ccccc1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
168276220 | 190530 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 261 | 6 | 1 | 1 | 4.2 | CCCCCCCc1cc(=O)c2cc(F)ccc2[nH]1 | 10.1021/acs.jmedchem.1c02191 | |||
CHEMBL5177954 | 190530 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 261 | 6 | 1 | 1 | 4.2 | CCCCCCCc1cc(=O)c2cc(F)ccc2[nH]1 | 10.1021/acs.jmedchem.1c02191 | |||
145958774 | 162360 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 404 | 6 | 3 | 3 | 2.9 | Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4163811 | 162360 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 404 | 6 | 3 | 3 | 2.9 | Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
145950877 | 163090 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 448 | 4 | 4 | 5 | 2.6 | Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4175360 | 163090 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 448 | 4 | 4 | 5 | 2.6 | Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
44450135 | 158795 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 493 | 14 | 3 | 8 | 1.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1ccccc1 | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL409327 | 158795 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 493 | 14 | 3 | 8 | 1.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1ccccc1 | 10.1016/j.bmcl.2008.03.059 | |||
44454302 | 159474 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 479 | 12 | 3 | 10 | 2.0 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL410060 | 159474 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 479 | 12 | 3 | 10 | 2.0 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O | 10.1016/j.bmcl.2008.01.100 | |||
16203237 | 97004 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 496 | 10 | 3 | 6 | 4.3 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1 | 10.1021/jm070024h | |||
CHEMBL266199 | 97004 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 496 | 10 | 3 | 6 | 4.3 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1 | 10.1021/jm070024h | |||
56926462 | 69059 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 506 | 3 | 3 | 5 | 2.1 | C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C | 10.1021/jm2007062 | |||
CHEMBL1923610 | 69059 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 506 | 3 | 3 | 5 | 2.1 | C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C | 10.1021/jm2007062 | |||
162660604 | 181325 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 700 | 15 | 3 | 9 | 5.0 | COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL4761319 | 181325 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 700 | 15 | 3 | 9 | 5.0 | COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
145956753 | 162251 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 404 | 6 | 3 | 3 | 2.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4162000 | 162251 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 404 | 6 | 3 | 3 | 2.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
71453489 | 211827 | None | 18 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
CHEMBL2170781 | 211827 | None | 18 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
44446190 | 94609 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 618 | 11 | 3 | 7 | 6.3 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
CHEMBL251855 | 94609 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 618 | 11 | 3 | 7 | 6.3 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
44446189 | 155464 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 618 | 11 | 3 | 7 | 6.3 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
CHEMBL403426 | 155464 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 618 | 11 | 3 | 7 | 6.3 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
10744738 | 16211 | None | 0 | Rat | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 528 | 11 | 2 | 4 | 3.7 | CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1cccc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
CHEMBL122420 | 16211 | None | 0 | Rat | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 528 | 11 | 2 | 4 | 3.7 | CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1cccc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
CHEMBL2170699 | 211818 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
44454432 | 155348 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 461 | 12 | 2 | 8 | 2.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL402808 | 155348 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 461 | 12 | 2 | 8 | 2.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.100 | |||
44454397 | 155614 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 447 | 11 | 2 | 8 | 2.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC(C#N)Cc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL404227 | 155614 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 447 | 11 | 2 | 8 | 2.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC(C#N)Cc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.100 | |||
145949381 | 162810 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 411 | 4 | 4 | 4 | 3.0 | Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4170865 | 162810 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 411 | 4 | 4 | 4 | 3.0 | Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
22862431 | 30493 | None | 0 | Rat | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 474 | 5 | 3 | 4 | 3.3 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc3O2)CC1 | 10.1016/s0960-894x(97)10199-8 | |||
CHEMBL13930 | 30493 | None | 0 | Rat | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 474 | 5 | 3 | 4 | 3.3 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc3O2)CC1 | 10.1016/s0960-894x(97)10199-8 | |||
162653781 | 180588 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 732 | 15 | 4 | 8 | 6.2 | COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL4753046 | 180588 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 732 | 15 | 4 | 8 | 6.2 | COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
156013764 | 177376 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 585 | 7 | 1 | 7 | 3.0 | CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4636229 | 177376 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 585 | 7 | 1 | 7 | 3.0 | CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
145958317 | 162407 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 430 | 4 | 2 | 4 | 3.0 | CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4164531 | 162407 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 430 | 4 | 2 | 4 | 3.0 | CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
145949381 | 162810 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 411 | 4 | 4 | 4 | 3.0 | Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4170865 | 162810 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 411 | 4 | 4 | 4 | 3.0 | Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
145950877 | 163090 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 448 | 4 | 4 | 5 | 2.6 | Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4175360 | 163090 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 448 | 4 | 4 | 5 | 2.6 | Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
156013764 | 177376 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 585 | 7 | 1 | 7 | 3.0 | CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4636229 | 177376 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 585 | 7 | 1 | 7 | 3.0 | CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
156020452 | 178139 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 523 | 6 | 4 | 5 | 2.2 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4646979 | 178139 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 523 | 6 | 4 | 5 | 2.2 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
24969201 | 88915 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 476 | 6 | 2 | 7 | 4.0 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1Cl | 10.6019/CHEMBL2364335 | |||
CHEMBL2364344 | 88915 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 476 | 6 | 2 | 7 | 4.0 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1Cl | 10.6019/CHEMBL2364335 | |||
69197403 | 88940 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 465 | 5 | 2 | 6 | 4.6 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc2cc(Cl)ccc2s1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364369 | 88940 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 465 | 5 | 2 | 6 | 4.6 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc2cc(Cl)ccc2s1 | 10.6019/CHEMBL2364335 | |||
59007071 | 88954 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 444 | 5 | 3 | 7 | 3.5 | C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364383 | 88954 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 444 | 5 | 3 | 7 | 3.5 | C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
11547135 | 88967 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 461 | 5 | 2 | 5 | 5.1 | C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccc(Cl)s4)cc3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364396 | 88967 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 461 | 5 | 2 | 5 | 5.1 | C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccc(Cl)s4)cc3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
11567764 | 88971 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 411 | 5 | 2 | 6 | 2.9 | C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-n4cccn4)cc3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364400 | 88971 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 411 | 5 | 2 | 6 | 2.9 | C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-n4cccn4)cc3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
11511157 | 88981 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2C)s1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364410 | 88981 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2C)s1 | 10.6019/CHEMBL2364335 | |||
11547599 | 88983 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 485 | 6 | 2 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2ccc(-c3c(C)cccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364412 | 88983 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 485 | 6 | 2 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2ccc(-c3c(C)cccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
69197133 | 88993 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 477 | 6 | 2 | 7 | 4.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)s1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364421 | 88993 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 477 | 6 | 2 | 7 | 4.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)s1 | 10.6019/CHEMBL2364335 | |||
69197849 | 89018 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 429 | 5 | 2 | 5 | 4.1 | C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364445 | 89018 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 429 | 5 | 2 | 5 | 4.1 | C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
69198350 | 89025 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 465 | 6 | 2 | 9 | 3.3 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csnn2)s1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364452 | 89025 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 465 | 6 | 2 | 9 | 3.3 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csnn2)s1 | 10.6019/CHEMBL2364335 | |||
156020452 | 178139 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 523 | 6 | 4 | 5 | 2.2 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4646979 | 178139 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 523 | 6 | 4 | 5 | 2.2 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44579860 | 189009 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 392 | 6 | 1 | 3 | 4.5 | CC(Oc1ccccc1Cl)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL507551 | 189009 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 392 | 6 | 1 | 3 | 4.5 | CC(Oc1ccccc1Cl)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1 | 10.1016/j.bmcl.2008.07.120 | |||
145956415 | 162157 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 416 | 4 | 2 | 4 | 2.6 | CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4160541 | 162157 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 416 | 4 | 2 | 4 | 2.6 | CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
145956415 | 162157 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 416 | 4 | 2 | 4 | 2.6 | CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4160541 | 162157 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 416 | 4 | 2 | 4 | 2.6 | CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
145956753 | 162251 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 404 | 6 | 3 | 3 | 2.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4162000 | 162251 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 404 | 6 | 3 | 3 | 2.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
145958774 | 162360 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 404 | 6 | 3 | 3 | 2.9 | Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4163811 | 162360 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 404 | 6 | 3 | 3 | 2.9 | Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
145955718 | 162630 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 432 | 4 | 2 | 5 | 2.0 | CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4167965 | 162630 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 432 | 4 | 2 | 5 | 2.0 | CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
145952404 | 162831 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 446 | 4 | 2 | 5 | 2.4 | CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4171300 | 162831 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 446 | 4 | 2 | 5 | 2.4 | CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL3578014 | 214225 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O | 10.1021/jm501702q | |||||
44436816 | 91839 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 524 | 12 | 4 | 6 | 3.9 | COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1 | 10.1021/jm0704550 | |||
CHEMBL241242 | 91839 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 524 | 12 | 4 | 6 | 3.9 | COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1 | 10.1021/jm0704550 | |||
44391028 | 64319 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 451 | 9 | 1 | 4 | 3.9 | CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL181051 | 64319 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 451 | 9 | 1 | 4 | 3.9 | CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
44390906 | 132171 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 467 | 7 | 2 | 5 | 4.2 | CC(C)(CN)CNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL369571 | 132171 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 467 | 7 | 2 | 5 | 4.2 | CC(C)(CN)CNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C | 10.1016/j.bmcl.2005.02.040 | |||
44434052 | 89450 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 487 | 11 | 3 | 9 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccc(NS(C)(=O)=O)cc1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL237059 | 89450 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 487 | 11 | 3 | 9 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccc(NS(C)(=O)=O)cc1 | 10.1016/j.bmcl.2007.07.099 | |||
44450169 | 159844 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 471 | 12 | 3 | 8 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCC(F)(F)F | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL410499 | 159844 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 471 | 12 | 3 | 8 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCC(F)(F)F | 10.1016/j.bmcl.2008.03.059 | |||
56926894 | 69086 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 538 | 3 | 3 | 5 | 2.6 | C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1 | 10.1021/jm2007062 | |||
CHEMBL1923638 | 69086 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 538 | 3 | 3 | 5 | 2.6 | C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1 | 10.1021/jm2007062 | |||
44391027 | 128871 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 541 | 12 | 1 | 4 | 5.6 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCc1ccccc1)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL366916 | 128871 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 541 | 12 | 1 | 4 | 5.6 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCc1ccccc1)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
44579803 | 186875 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 406 | 7 | 1 | 3 | 4.5 | CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL488966 | 186875 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 406 | 7 | 1 | 3 | 4.5 | CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
145952404 | 162831 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 446 | 4 | 2 | 5 | 2.4 | CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4171300 | 162831 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 446 | 4 | 2 | 5 | 2.4 | CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL3578014 | 214225 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O | 10.1021/jm501702q | |||||
11526696 | 71626 | None | 17 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 538 | 3 | 3 | 5 | 2.6 | C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1 | 10.1021/jm1012374 | |||
CHEMBL1923502 | 71626 | None | 17 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 538 | 3 | 3 | 5 | 2.6 | C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1 | 10.1021/jm1012374 | |||
CHEMBL1963249 | 71626 | None | 17 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 538 | 3 | 3 | 5 | 2.6 | C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1 | 10.1021/jm1012374 | |||
44450045 | 159330 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 447 | 14 | 4 | 9 | 0.1 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCO | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL409894 | 159330 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 447 | 14 | 4 | 9 | 0.1 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCO | 10.1016/j.bmcl.2008.03.059 | |||
44434012 | 89108 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 479 | 13 | 3 | 8 | 1.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL236513 | 89108 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 479 | 13 | 3 | 8 | 1.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1 | 10.1016/j.bmcl.2007.07.099 | |||
44454398 | 97651 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 447 | 11 | 2 | 8 | 2.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1 | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL270851 | 97651 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 447 | 11 | 2 | 8 | 2.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1 | 10.1016/j.bmcl.2008.01.100 | |||
11526745 | 69090 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 542 | 3 | 3 | 5 | 2.3 | C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C | 10.1021/jm2007062 | |||
CHEMBL1923642 | 69090 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 542 | 3 | 3 | 5 | 2.3 | C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C | 10.1021/jm2007062 | |||
44391020 | 63885 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 543 | 11 | 1 | 5 | 5.7 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OCc1ccccc1)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL180337 | 63885 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 543 | 11 | 1 | 5 | 5.7 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OCc1ccccc1)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
162643920 | 181886 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 679 | 14 | 4 | 8 | 5.4 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL4777792 | 181886 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 679 | 14 | 4 | 8 | 5.4 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
155540883 | 173060 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 4548 | 115 | 75 | 66 | -23.9 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
CHEMBL4517399 | 173060 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 4548 | 115 | 75 | 66 | -23.9 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
145955718 | 162630 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 432 | 4 | 2 | 5 | 2.0 | CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4167965 | 162630 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 432 | 4 | 2 | 5 | 2.0 | CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
23648236 | 79183 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 524 | 13 | 3 | 7 | 4.4 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1 | 10.1021/jm0704550 | |||
CHEMBL2113317 | 79183 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 524 | 13 | 3 | 7 | 4.4 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1 | 10.1021/jm0704550 | |||
145958317 | 162407 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 430 | 4 | 2 | 4 | 3.0 | CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4164531 | 162407 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 430 | 4 | 2 | 4 | 3.0 | CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
162649014 | 180047 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 702 | 14 | 4 | 7 | 6.2 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL4746362 | 180047 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 702 | 14 | 4 | 7 | 6.2 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
44434123 | 145638 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 343 | 8 | 2 | 8 | 0.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL391510 | 145638 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 343 | 8 | 2 | 8 | 0.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N | 10.1016/j.bmcl.2007.07.099 | |||
11526696 | 71626 | None | 17 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 538 | 3 | 3 | 5 | 2.6 | C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1 | 10.1021/jm2007062 | |||
CHEMBL1923502 | 71626 | None | 17 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 538 | 3 | 3 | 5 | 2.6 | C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1 | 10.1021/jm2007062 | |||
CHEMBL1963249 | 71626 | None | 17 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 538 | 3 | 3 | 5 | 2.6 | C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1 | 10.1021/jm2007062 | |||
122178179 | 121327 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 1002 | 29 | 10 | 9 | 3.8 | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O | 10.1021/jm501702q | |||
CHEMBL3578008 | 121327 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 1002 | 29 | 10 | 9 | 3.8 | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O | 10.1021/jm501702q | |||
145980382 | 166738 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 601 | 5 | 1 | 4 | 7.4 | Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4281310 | 166738 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 601 | 5 | 1 | 4 | 7.4 | Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
71453489 | 211827 | None | 18 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
CHEMBL2170781 | 211827 | None | 18 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
134149793 | 148693 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 508 | 5 | 3 | 5 | 2.5 | CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O | nan | |||
CHEMBL3939196 | 148693 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 508 | 5 | 3 | 5 | 2.5 | CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O | nan | |||
145980333 | 166676 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 577 | 6 | 1 | 4 | 7.5 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4280040 | 166676 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 577 | 6 | 1 | 4 | 7.5 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
44579823 | 184187 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 386 | 7 | 1 | 3 | 4.2 | Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL482420 | 184187 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 386 | 7 | 1 | 3 | 4.2 | Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1 | 10.1016/j.bmcl.2008.07.120 | |||
145957075 | 162373 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 447 | 4 | 4 | 4 | 3.2 | Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4164040 | 162373 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 447 | 4 | 4 | 4 | 3.2 | Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
145951150 | 162871 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 443 | 4 | 3 | 5 | 3.1 | Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4171914 | 162871 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 443 | 4 | 3 | 5 | 3.1 | Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21 | 10.1021/acs.jmedchem.8b00322 | |||
44449864 | 158922 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 539 | 16 | 4 | 10 | 1.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCCCO)c1 | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL409462 | 158922 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 539 | 16 | 4 | 10 | 1.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCCCO)c1 | 10.1016/j.bmcl.2008.03.059 | |||
10005618 | 10325 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 485 | 11 | 1 | 3 | 4.9 | CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1162058 | 10325 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 485 | 11 | 1 | 3 | 4.9 | CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1 | 10.1016/j.bmc.2007.01.057 | |||
15481181 | 77773 | None | 3 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 505 | 9 | 2 | 6 | 1.7 | CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL209020 | 77773 | None | 3 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 505 | 9 | 2 | 6 | 1.7 | CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O | 10.1016/j.bmc.2007.01.057 | |||
9810101 | 99303 | None | 14 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 5 | 2 | ChEMBL | 528 | 11 | 2 | 4 | 3.7 | CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL281764 | 99303 | None | 14 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 5 | 2 | ChEMBL | 528 | 11 | 2 | 4 | 3.7 | CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||
15481188 | 141297 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 491 | 9 | 3 | 6 | 1.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL382844 | 141297 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 491 | 9 | 3 | 6 | 1.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL130229 | 211146 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||||
16114292 | 96987 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 601 | 11 | 4 | 6 | 5.5 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1 | 10.1021/jm0704550 | |||
CHEMBL266063 | 96987 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 601 | 11 | 4 | 6 | 5.5 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1 | 10.1021/jm0704550 | |||
16114292 | 96987 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 601 | 11 | 4 | 6 | 5.5 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
CHEMBL266063 | 96987 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 601 | 11 | 4 | 6 | 5.5 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
23730225 | 154265 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 435 | 12 | 4 | 10 | -0.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCO | 10.1021/jm7010595 | |||
CHEMBL398570 | 154265 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 435 | 12 | 4 | 10 | -0.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCO | 10.1021/jm7010595 | |||
10530781 | 15585 | None | 0 | Rat | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 554 | 12 | 2 | 4 | 4.2 | CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
CHEMBL122108 | 15585 | None | 0 | Rat | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 554 | 12 | 2 | 4 | 4.2 | CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
10005618 | 10325 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 485 | 11 | 1 | 3 | 4.9 | CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1162058 | 10325 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 485 | 11 | 1 | 3 | 4.9 | CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1 | 10.1016/j.bmc.2007.01.057 | |||
15481181 | 77773 | None | 3 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 505 | 9 | 2 | 6 | 1.7 | CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL209020 | 77773 | None | 3 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 505 | 9 | 2 | 6 | 1.7 | CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O | 10.1016/j.bmc.2007.01.057 | |||
9810101 | 99303 | None | 14 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 5 | 2 | ChEMBL | 528 | 11 | 2 | 4 | 3.7 | CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL281764 | 99303 | None | 14 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 5 | 2 | ChEMBL | 528 | 11 | 2 | 4 | 3.7 | CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||
15481188 | 141297 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 491 | 9 | 3 | 6 | 1.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL382844 | 141297 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 491 | 9 | 3 | 6 | 1.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL130229 | 211146 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||||
156011385 | 177483 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 518 | 8 | 3 | 5 | 1.3 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4637916 | 177483 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 518 | 8 | 3 | 5 | 1.3 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44449956 | 96668 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 523 | 14 | 3 | 9 | 2.0 | CN(CCc1cccc(O)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL263389 | 96668 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 523 | 14 | 3 | 9 | 2.0 | CN(CCc1cccc(O)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2008.03.059 | |||
44447846 | 94952 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 547 | 15 | 4 | 11 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1cccc(OC(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
CHEMBL254166 | 94952 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 547 | 15 | 4 | 11 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1cccc(OC(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
44444566 | 154857 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 470 | 5 | 1 | 7 | 3.4 | COc1cc2c(cc1N1CCN[C@@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
CHEMBL400124 | 154857 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 470 | 5 | 1 | 7 | 3.4 | COc1cc2c(cc1N1CCN[C@@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
156011385 | 177483 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 518 | 8 | 3 | 5 | 1.3 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4637916 | 177483 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 518 | 8 | 3 | 5 | 1.3 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
156019457 | 178047 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 515 | 8 | 3 | 7 | 0.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4645625 | 178047 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 515 | 8 | 3 | 7 | 0.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44570961 | 192670 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 421 | 4 | 1 | 5 | 2.2 | N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)c(F)c2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL521246 | 192670 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 421 | 4 | 1 | 5 | 2.2 | N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)c(F)c2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
69195095 | 88997 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 475 | 6 | 2 | 6 | 4.6 | COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)c(F)c2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364425 | 88997 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 475 | 6 | 2 | 6 | 4.6 | COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)c(F)c2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
69194503 | 89033 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 491 | 6 | 2 | 6 | 5.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1Cl | 10.6019/CHEMBL2364335 | |||
CHEMBL2364460 | 89033 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 491 | 6 | 2 | 6 | 5.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1Cl | 10.6019/CHEMBL2364335 | |||
59007103 | 89059 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 456 | 6 | 2 | 7 | 3.6 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cn1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364485 | 89059 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 456 | 6 | 2 | 7 | 3.6 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cn1 | 10.6019/CHEMBL2364335 | |||
69197358 | 89065 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 459 | 5 | 3 | 6 | 4.1 | Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2F)o1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364491 | 89065 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 459 | 5 | 3 | 6 | 4.1 | Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2F)o1 | 10.6019/CHEMBL2364335 | |||
44450046 | 95909 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 501 | 14 | 4 | 9 | -0.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCN1CCNC1=O | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL259016 | 95909 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 501 | 14 | 4 | 9 | -0.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCN1CCNC1=O | 10.1016/j.bmcl.2008.03.059 | |||
23730341 | 89776 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 502 | 11 | 3 | 10 | 0.1 | CC(=O)N[C@@H]1CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1 | 10.1021/jm7010595 | |||
CHEMBL237701 | 89776 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 502 | 11 | 3 | 10 | 0.1 | CC(=O)N[C@@H]1CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1 | 10.1021/jm7010595 | |||
71453489 | 211827 | None | 18 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
CHEMBL2170781 | 211827 | None | 18 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
44390914 | 63659 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 495 | 11 | 1 | 5 | 4.9 | CCCOC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL180093 | 63659 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 495 | 11 | 1 | 5 | 4.9 | CCCOC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
22888424 | 123064 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 541 | 11 | 1 | 4 | 5.7 | CC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1 | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL360877 | 123064 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 541 | 11 | 1 | 4 | 5.7 | CC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1 | 10.1016/j.bmcl.2005.02.040 | |||
71453489 | 211827 | None | 18 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
CHEMBL2170781 | 211827 | None | 18 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
162671996 | 182937 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 707 | 16 | 3 | 8 | 6.1 | COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL4791255 | 182937 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 707 | 16 | 3 | 8 | 6.1 | COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
23730228 | 89626 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 477 | 14 | 3 | 10 | 0.6 | CN(CCCCO)C(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1021/jm7010595 | |||
CHEMBL237492 | 89626 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 477 | 14 | 3 | 10 | 0.6 | CN(CCCCO)C(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1021/jm7010595 | |||
71453489 | 211827 | None | 18 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
CHEMBL2170781 | 211827 | None | 18 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
44444568 | 94031 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 470 | 5 | 1 | 7 | 3.4 | COc1cc2c(cc1N1CCN[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
CHEMBL248542 | 94031 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 470 | 5 | 1 | 7 | 3.4 | COc1cc2c(cc1N1CCN[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
15481185 | 77290 | None | 1 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 519 | 10 | 2 | 6 | 2.1 | CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL207970 | 77290 | None | 1 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 519 | 10 | 2 | 6 | 2.1 | CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O | 10.1016/j.bmc.2007.01.057 | |||
156011736 | 177528 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 605 | 7 | 3 | 7 | 3.0 | Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4638566 | 177528 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 605 | 7 | 3 | 7 | 3.0 | Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
25022506 | 95320 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 457 | 6 | 2 | 6 | 4.4 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL256263 | 95320 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 457 | 6 | 2 | 6 | 4.4 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
24803347 | 155118 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 441 | 6 | 2 | 6 | 3.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL401548 | 155118 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 441 | 6 | 2 | 6 | 3.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
46882394 | 5844 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 1 | 2 | ChEMBL | 438 | 8 | 2 | 4 | 4.2 | CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc[nH]2)CC3)cc1 | 10.1016/j.bmcl.2009.09.027 | |||
CHEMBL1079185 | 5844 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 1 | 2 | ChEMBL | 438 | 8 | 2 | 4 | 4.2 | CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc[nH]2)CC3)cc1 | 10.1016/j.bmcl.2009.09.027 | |||
46882395 | 5845 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 2 | ChEMBL | 452 | 8 | 2 | 4 | 4.5 | CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2[nH]cnc2C)CC3)cc1 | 10.1016/j.bmcl.2009.09.027 | |||
CHEMBL1079186 | 5845 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 2 | ChEMBL | 452 | 8 | 2 | 4 | 4.5 | CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2[nH]cnc2C)CC3)cc1 | 10.1016/j.bmcl.2009.09.027 | |||
44570699 | 191414 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 474 | 5 | 2 | 5 | 2.2 | N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3F)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL519121 | 191414 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 474 | 5 | 2 | 5 | 2.2 | N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3F)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
69196498 | 88945 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 463 | 6 | 2 | 7 | 4.5 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)s1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364374 | 88945 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 463 | 6 | 2 | 7 | 4.5 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)s1 | 10.6019/CHEMBL2364335 | |||
69197028 | 88984 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)c3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364413 | 88984 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)c3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
69198238 | 88995 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 441 | 5 | 2 | 5 | 4.7 | Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364423 | 88995 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 441 | 5 | 2 | 5 | 4.7 | Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1 | 10.6019/CHEMBL2364335 | |||
11712867 | 89032 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 489 | 6 | 2 | 6 | 4.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)cc1F | 10.6019/CHEMBL2364335 | |||
CHEMBL2364459 | 89032 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 489 | 6 | 2 | 6 | 4.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)cc1F | 10.6019/CHEMBL2364335 | |||
69194471 | 89047 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 489 | 6 | 2 | 6 | 4.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(F)c1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364473 | 89047 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 489 | 6 | 2 | 6 | 4.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(F)c1 | 10.6019/CHEMBL2364335 | |||
11698505 | 89056 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364482 | 89056 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1 | 10.6019/CHEMBL2364335 | |||
9950632 | 88740 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 357 | 9 | 2 | 8 | 0.7 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N | 10.1016/j.bmcl.2008.05.100 | |||
CHEMBL236038 | 88740 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 357 | 9 | 2 | 8 | 0.7 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N | 10.1016/j.bmcl.2008.05.100 | |||
44579880 | 186941 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 415 | 7 | 2 | 4 | 3.9 | CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL489401 | 186941 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 415 | 7 | 2 | 4 | 3.9 | CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
44579841 | 192663 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 406 | 7 | 1 | 3 | 4.5 | CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL521176 | 192663 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 406 | 7 | 1 | 3 | 4.5 | CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
44434010 | 88807 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 445 | 14 | 3 | 8 | 1.5 | CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL236311 | 88807 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 445 | 14 | 3 | 8 | 1.5 | CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2008.03.059 | |||
9950632 | 88740 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 357 | 9 | 2 | 8 | 0.7 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N | 10.1016/j.bmcl.2007.07.099 | |||
9950632 | 88740 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 357 | 9 | 2 | 8 | 0.7 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL236038 | 88740 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 357 | 9 | 2 | 8 | 0.7 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL236038 | 88740 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 357 | 9 | 2 | 8 | 0.7 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N | 10.1016/j.bmcl.2008.01.100 | |||
44434010 | 88807 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 445 | 14 | 3 | 8 | 1.5 | CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL236311 | 88807 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 445 | 14 | 3 | 8 | 1.5 | CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2007.07.099 | |||
44437966 | 204550 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 607 | 8 | 1 | 5 | 4.8 | CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL608827 | 204550 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 607 | 8 | 1 | 5 | 4.8 | CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F | 10.1016/j.bmc.2007.01.057 | |||
44437969 | 204976 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 565 | 8 | 1 | 4 | 5.0 | CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL611488 | 204976 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 565 | 8 | 1 | 4 | 5.0 | CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F | 10.1016/j.bmc.2007.01.057 | |||
44437966 | 204550 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 607 | 8 | 1 | 5 | 4.8 | CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL608827 | 204550 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 607 | 8 | 1 | 5 | 4.8 | CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F | 10.1016/j.bmc.2007.01.057 | |||
44437969 | 204976 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 565 | 8 | 1 | 4 | 5.0 | CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL611488 | 204976 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 565 | 8 | 1 | 4 | 5.0 | CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F | 10.1016/j.bmc.2007.01.057 | |||
44454368 | 95315 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 447 | 11 | 2 | 8 | 2.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCC(C#N)c2ccccc2)n1 | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL256236 | 95315 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 447 | 11 | 2 | 8 | 2.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCC(C#N)c2ccccc2)n1 | 10.1016/j.bmcl.2008.01.100 | |||
145987684 | 167373 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 615 | 6 | 1 | 4 | 7.8 | CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4293331 | 167373 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 615 | 6 | 1 | 4 | 7.8 | CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
44444560 | 155044 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 541 | 5 | 1 | 5 | 3.4 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)Cc1cccc(I)c1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
CHEMBL401133 | 155044 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 541 | 5 | 1 | 5 | 3.4 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)Cc1cccc(I)c1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
145953855 | 162610 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 426 | 6 | 3 | 3 | 2.9 | CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4167669 | 162610 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 426 | 6 | 3 | 3 | 2.9 | CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
44570923 | 184062 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 403 | 4 | 1 | 5 | 2.0 | N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL481602 | 184062 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 403 | 4 | 1 | 5 | 2.0 | N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
44570761 | 190081 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 413 | 4 | 1 | 4 | 2.5 | NC1CCN(C(=O)C2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL517081 | 190081 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 413 | 4 | 1 | 4 | 2.5 | NC1CCN(C(=O)C2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
122178179 | 121327 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 1002 | 29 | 10 | 9 | 3.8 | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O | 10.1021/jm501702q | |||
CHEMBL3578008 | 121327 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 1002 | 29 | 10 | 9 | 3.8 | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O | 10.1021/jm501702q | |||
24969112 | 88910 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 445 | 5 | 2 | 7 | 3.2 | Cc1ccc(-c2ccc(S(=O)(=O)Nc3ccnc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364339 | 88910 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 445 | 5 | 2 | 7 | 3.2 | Cc1ccc(-c2ccc(S(=O)(=O)Nc3ccnc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1 | 10.6019/CHEMBL2364335 | |||
11540248 | 88916 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 479 | 5 | 2 | 6 | 4.9 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364345 | 88916 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 479 | 5 | 2 | 6 | 4.9 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
11647560 | 88918 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 425 | 5 | 2 | 5 | 3.8 | COc1ccc(NS(=O)(=O)c2cccc3ccccc23)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364347 | 88918 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 425 | 5 | 2 | 5 | 3.8 | COc1ccc(NS(=O)(=O)c2cccc3ccccc23)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
69196005 | 88949 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 463 | 5 | 2 | 6 | 4.3 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1sc2ccc(F)cc2c1C | 10.6019/CHEMBL2364335 | |||
CHEMBL2364378 | 88949 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 463 | 5 | 2 | 6 | 4.3 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1sc2ccc(F)cc2c1C | 10.6019/CHEMBL2364335 | |||
69198434 | 88957 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 488 | 7 | 2 | 8 | 3.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccc2OC)s1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364386 | 88957 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 488 | 7 | 2 | 8 | 3.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccc2OC)s1 | 10.6019/CHEMBL2364335 | |||
69198286 | 88965 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 401 | 4 | 2 | 5 | 3.9 | C[C@H]1CN(c2cccc(NS(=O)(=O)c3cc4ccccc4s3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364394 | 88965 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 401 | 4 | 2 | 5 | 3.9 | C[C@H]1CN(c2cccc(NS(=O)(=O)c3cc4ccccc4s3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
11562181 | 88976 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 487 | 6 | 2 | 5 | 4.6 | COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(F)c3F)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364405 | 88976 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 487 | 6 | 2 | 5 | 4.6 | COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(F)c3F)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
69196132 | 88987 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 475 | 6 | 2 | 6 | 4.6 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2)s1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364416 | 88987 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 475 | 6 | 2 | 6 | 4.6 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2)s1 | 10.6019/CHEMBL2364335 | |||
69197703 | 88988 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)cc2)s1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364417 | 88988 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)cc2)s1 | 10.6019/CHEMBL2364335 | |||
69194443 | 89009 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 487 | 6 | 2 | 5 | 4.6 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2F)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364436 | 89009 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 487 | 6 | 2 | 5 | 4.6 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2F)cc1 | 10.6019/CHEMBL2364335 | |||
11503069 | 89012 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 439 | 5 | 2 | 4 | 4.5 | C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccc4)cc3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364439 | 89012 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 439 | 5 | 2 | 4 | 4.5 | C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccc4)cc3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
11647941 | 89019 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 443 | 5 | 2 | 5 | 4.4 | Cc1cc(-c2ccoc2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F | 10.6019/CHEMBL2364335 | |||
CHEMBL2364446 | 89019 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 443 | 5 | 2 | 5 | 4.4 | Cc1cc(-c2ccoc2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F | 10.6019/CHEMBL2364335 | |||
11576203 | 89026 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 459 | 5 | 2 | 6 | 3.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)CCC(C)(C)O2 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364453 | 89026 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 459 | 5 | 2 | 6 | 3.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)CCC(C)(C)O2 | 10.6019/CHEMBL2364335 | |||
11683891 | 89040 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 453 | 6 | 2 | 7 | 3.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccn2)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364467 | 89040 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 453 | 6 | 2 | 7 | 3.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccn2)cc1 | 10.6019/CHEMBL2364335 | |||
69194380 | 89064 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 443 | 6 | 2 | 6 | 4.0 | COc1ccc(N2CCN[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364490 | 89064 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 443 | 6 | 2 | 6 | 4.0 | COc1ccc(N2CCN[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1 | 10.6019/CHEMBL2364335 | |||
56926783 | 69080 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 470 | 4 | 3 | 4 | 2.8 | CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | 10.1021/jm2007062 | |||
CHEMBL1923632 | 69080 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 470 | 4 | 3 | 4 | 2.8 | CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | 10.1021/jm2007062 | |||
156021183 | 178229 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 511 | 8 | 3 | 5 | 2.0 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4648308 | 178229 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 511 | 8 | 3 | 5 | 2.0 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
156017268 | 177755 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 497 | 8 | 3 | 5 | 1.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4641472 | 177755 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 497 | 8 | 3 | 5 | 1.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
156021183 | 178229 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 511 | 8 | 3 | 5 | 2.0 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4648308 | 178229 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 511 | 8 | 3 | 5 | 2.0 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44453070 | 95146 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 453 | 6 | 2 | 7 | 3.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cncnc2)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL255401 | 95146 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 453 | 6 | 2 | 7 | 3.1 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cncnc2)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
44453097 | 155183 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 452 | 6 | 2 | 6 | 3.7 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccncc2)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL401891 | 155183 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 452 | 6 | 2 | 6 | 3.7 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccncc2)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
44570762 | 183534 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 414 | 4 | 1 | 5 | 1.9 | N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cccnc3)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL479865 | 183534 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 414 | 4 | 1 | 5 | 1.9 | N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cccnc3)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL3578013 | 214224 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O | 10.1021/jm501702q | |||||
156017268 | 177755 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 497 | 8 | 3 | 5 | 1.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4641472 | 177755 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 497 | 8 | 3 | 5 | 1.6 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44434114 | 89452 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 452 | 10 | 2 | 9 | 1.5 | COC(=O)C(c1ccccc1)n1nnc([C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)n1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL237060 | 89452 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 452 | 10 | 2 | 9 | 1.5 | COC(=O)C(c1ccccc1)n1nnc([C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)n1 | 10.1016/j.bmcl.2007.07.099 | |||
44450134 | 161986 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 479 | 13 | 3 | 8 | 1.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCc1ccccc1 | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL415095 | 161986 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 479 | 13 | 3 | 8 | 1.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCc1ccccc1 | 10.1016/j.bmcl.2008.03.059 | |||
44446177 | 94700 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 601 | 11 | 4 | 6 | 5.5 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
CHEMBL252448 | 94700 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 601 | 11 | 4 | 6 | 5.5 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
CHEMBL500468 | 216603 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | None | None | None | CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O | 10.1016/s0960-894x(01)00324-9 | |||||
44450105 | 95855 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 507 | 15 | 3 | 8 | 2.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCc1ccccc1 | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL258762 | 95855 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 507 | 15 | 3 | 8 | 2.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCc1ccccc1 | 10.1016/j.bmcl.2008.03.059 | |||
44447848 | 94953 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 547 | 15 | 4 | 11 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccc(OC(F)(F)F)cc1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
CHEMBL254167 | 94953 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 547 | 15 | 4 | 11 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccc(OC(F)(F)F)cc1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
172462089 | 196556 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 2481 | 92 | 38 | 37 | -12.0 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C | 10.1039/d3md00441d | |||
CHEMBL5426545 | 196556 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 2481 | 92 | 38 | 37 | -12.0 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C | 10.1039/d3md00441d | |||
44580031 | 193179 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 381 | 7 | 2 | 4 | 3.2 | CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL522446 | 193179 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 381 | 7 | 2 | 4 | 3.2 | CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL3578013 | 214224 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O | 10.1021/jm501702q | |||||
44447845 | 94931 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 599 | 14 | 4 | 10 | 2.3 | CC(C)(N)C(=O)N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
CHEMBL253966 | 94931 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 599 | 14 | 4 | 10 | 2.3 | CC(C)(N)C(=O)N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
44434119 | 89940 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 400 | 10 | 3 | 10 | -0.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL237925 | 89940 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 400 | 10 | 3 | 10 | -0.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1 | 10.1016/j.bmcl.2007.07.099 | |||
145953855 | 162610 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 426 | 6 | 3 | 3 | 2.9 | CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4167669 | 162610 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 426 | 6 | 3 | 3 | 2.9 | CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
44434121 | 89942 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 385 | 11 | 2 | 8 | 1.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL237927 | 89942 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 385 | 11 | 2 | 8 | 1.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N | 10.1016/j.bmcl.2007.07.099 | |||
162646324 | 179842 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 688 | 17 | 3 | 9 | 4.8 | CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL4744139 | 179842 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 688 | 17 | 3 | 9 | 4.8 | CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
10721075 | 15560 | None | 0 | Rat | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 534 | 11 | 2 | 5 | 3.8 | CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1csc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
CHEMBL121960 | 15560 | None | 0 | Rat | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 534 | 11 | 2 | 5 | 3.8 | CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1csc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
145959787 | 162379 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 444 | 4 | 2 | 4 | 3.4 | CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4164107 | 162379 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 444 | 4 | 2 | 4 | 3.4 | CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
16114289 | 98718 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 562 | 11 | 3 | 6 | 5.0 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1 | 10.1021/jm0704550 | |||
CHEMBL277376 | 98718 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 562 | 11 | 3 | 6 | 5.0 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1 | 10.1021/jm0704550 | |||
56926892 | 69084 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 534 | 4 | 3 | 4 | 3.7 | CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | 10.1021/jm2007062 | |||
CHEMBL1923636 | 69084 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 534 | 4 | 3 | 4 | 3.7 | CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | 10.1021/jm2007062 | |||
145984632 | 166486 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 629 | 5 | 1 | 4 | 8.0 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4276775 | 166486 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 629 | 5 | 1 | 4 | 8.0 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
155551597 | 174053 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 974 | 27 | 13 | 11 | -1.2 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
CHEMBL4541252 | 174053 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 974 | 27 | 13 | 11 | -1.2 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
22862448 | 97231 | None | 0 | Rat | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 488 | 5 | 3 | 5 | 3.0 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(=O)c1ccccc1O2 | 10.1016/s0960-894x(97)10199-8 | |||
CHEMBL268231 | 97231 | None | 0 | Rat | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 488 | 5 | 3 | 5 | 3.0 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(=O)c1ccccc1O2 | 10.1016/s0960-894x(97)10199-8 | |||
22867465 | 97272 | None | 0 | Rat | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 458 | 5 | 3 | 3 | 3.3 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2 | 10.1016/s0960-894x(97)10199-8 | |||
CHEMBL268518 | 97272 | None | 0 | Rat | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 458 | 5 | 3 | 3 | 3.3 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2 | 10.1016/s0960-894x(97)10199-8 | |||
44301387 | 11268 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 564 | 12 | 2 | 7 | 2.5 | CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 | 10.1016/s0960-894x(01)00324-9 | |||
CHEMBL1179088 | 11268 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 564 | 12 | 2 | 7 | 2.5 | CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 | 10.1016/s0960-894x(01)00324-9 | |||
CHEMBL59572 | 11268 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 564 | 12 | 2 | 7 | 2.5 | CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 | 10.1016/s0960-894x(01)00324-9 | |||
56926356 | 69041 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 510 | 4 | 4 | 6 | 1.8 | CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O | 10.1021/jm2007062 | |||
CHEMBL1923512 | 69041 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 510 | 4 | 4 | 6 | 1.8 | CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O | 10.1021/jm2007062 | |||
10143731 | 64349 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 543 | 11 | 2 | 5 | 4.7 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(O)c1ccccc1)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL181156 | 64349 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 543 | 11 | 2 | 5 | 4.7 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(O)c1ccccc1)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
44444558 | 167880 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 465 | 4 | 0 | 5 | 4.1 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
CHEMBL430398 | 167880 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 465 | 4 | 0 | 5 | 4.1 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
145959007 | 162351 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 436 | 4 | 4 | 5 | 2.8 | N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4163623 | 162351 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 436 | 4 | 4 | 5 | 2.8 | N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
145959787 | 162379 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 444 | 4 | 2 | 4 | 3.4 | CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4164107 | 162379 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 444 | 4 | 2 | 4 | 3.4 | CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
156021766 | 178232 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 497 | 8 | 3 | 5 | 1.6 | Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4648355 | 178232 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 497 | 8 | 3 | 5 | 1.6 | Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44452826 | 95435 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 428 | 5 | 2 | 6 | 3.8 | C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL256809 | 95435 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 428 | 5 | 2 | 6 | 3.8 | C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1 | 10.1016/j.bmcl.2007.12.021 | |||
44452777 | 96273 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 470 | 6 | 2 | 7 | 4.0 | CC(=O)c1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL260831 | 96273 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 470 | 6 | 2 | 7 | 4.0 | CC(=O)c1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1 | 10.1016/j.bmcl.2007.12.021 | |||
11554351 | 96592 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 458 | 6 | 2 | 6 | 2.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(N2CCCC2=O)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL262879 | 96592 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 458 | 6 | 2 | 6 | 2.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(N2CCCC2=O)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
11605061 | 96767 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 462 | 5 | 2 | 6 | 4.5 | C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL264170 | 96767 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 462 | 5 | 2 | 6 | 4.5 | C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1 | 10.1016/j.bmcl.2007.12.021 | |||
44452825 | 155340 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 472 | 7 | 2 | 7 | 4.2 | CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL402772 | 155340 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 472 | 7 | 2 | 7 | 4.2 | CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL3578017 | 214228 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -3 | 2 | ChEMBL | None | None | None | CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O | 10.1021/jm501702q | |||||
69197033 | 88941 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 442 | 6 | 2 | 7 | 3.3 | COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364370 | 88941 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 442 | 6 | 2 | 7 | 3.3 | COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
69197513 | 88956 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 448 | 6 | 2 | 8 | 3.4 | COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364385 | 88956 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 448 | 6 | 2 | 8 | 3.4 | COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
69196509 | 88960 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 467 | 5 | 2 | 5 | 3.8 | COc1ccc(NS(=O)(=O)c2ccc(Br)cc2C)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364389 | 88960 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 467 | 5 | 2 | 5 | 3.8 | COc1ccc(NS(=O)(=O)c2ccc(Br)cc2C)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
11669948 | 88972 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 467 | 5 | 2 | 5 | 3.8 | COc1ccc(NS(=O)(=O)c2ccc(Br)c(C)c2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364401 | 88972 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 467 | 5 | 2 | 5 | 3.8 | COc1ccc(NS(=O)(=O)c2ccc(Br)c(C)c2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
69196071 | 89030 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 478 | 6 | 2 | 8 | 4.2 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)n2)s1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364457 | 89030 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 478 | 6 | 2 | 8 | 4.2 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)n2)s1 | 10.6019/CHEMBL2364335 | |||
69194899 | 89034 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 441 | 6 | 2 | 6 | 3.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccoc2)c1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364461 | 89034 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 441 | 6 | 2 | 6 | 3.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccoc2)c1 | 10.6019/CHEMBL2364335 | |||
44434055 | 89339 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 487 | 11 | 3 | 9 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL236858 | 89339 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 487 | 11 | 3 | 9 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O | 10.1016/j.bmcl.2007.07.099 | |||
44436889 | 153146 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 563 | 11 | 3 | 5 | 6.2 | COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1 | 10.1021/jm0704550 | |||
CHEMBL397594 | 153146 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 563 | 11 | 3 | 5 | 6.2 | COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1 | 10.1021/jm0704550 | |||
44570922 | 192672 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 415 | 3 | 1 | 4 | 1.6 | N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(Br)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL521264 | 192672 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 415 | 3 | 1 | 4 | 1.6 | N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(Br)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
69196838 | 88921 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 426 | 5 | 2 | 6 | 3.2 | COc1ccc(NS(=O)(=O)c2cccc3cccnc23)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364350 | 88921 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 426 | 5 | 2 | 6 | 3.2 | COc1ccc(NS(=O)(=O)c2cccc3cccnc23)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
25211977 | 187008 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 372 | 7 | 1 | 3 | 3.9 | C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL489818 | 187008 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 372 | 7 | 1 | 3 | 3.9 | C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
16113580 | 137966 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 575 | 11 | 4 | 6 | 5.2 | COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1 | 10.1021/jm701292s | |||
CHEMBL376258 | 137966 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 575 | 11 | 4 | 6 | 5.2 | COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1 | 10.1021/jm701292s | |||
44434111 | 146371 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 525 | 11 | 2 | 10 | 1.8 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL392077 | 146371 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 525 | 11 | 2 | 10 | 1.8 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O | 10.1016/j.bmcl.2007.07.099 | |||
15481185 | 77290 | None | 1 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 519 | 10 | 2 | 6 | 2.1 | CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL207970 | 77290 | None | 1 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 519 | 10 | 2 | 6 | 2.1 | CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O | 10.1016/j.bmc.2007.01.057 | |||
127048059 | 139653 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 675 | 16 | 6 | 8 | 4.6 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3797225 | 139653 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 675 | 16 | 6 | 8 | 4.6 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
16113580 | 137966 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 575 | 11 | 4 | 6 | 5.2 | COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1 | 10.1021/jm070024h | |||
CHEMBL376258 | 137966 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 575 | 11 | 4 | 6 | 5.2 | COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1 | 10.1021/jm070024h | |||
44450103 | 95825 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 495 | 14 | 3 | 10 | -0.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(C)(=O)=O | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL258551 | 95825 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 495 | 14 | 3 | 10 | -0.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(C)(=O)=O | 10.1016/j.bmcl.2008.03.059 | |||
44391032 | 64866 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 513 | 8 | 1 | 5 | 5.7 | CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL182050 | 64866 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 513 | 8 | 1 | 5 | 5.7 | CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
156011736 | 177528 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 605 | 7 | 3 | 7 | 3.0 | Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4638566 | 177528 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 605 | 7 | 3 | 7 | 3.0 | Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
44450132 | 96065 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 447 | 14 | 4 | 9 | 0.1 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCCCO | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL259712 | 96065 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 447 | 14 | 4 | 9 | 0.1 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCCCO | 10.1016/j.bmcl.2008.03.059 | |||
145948725 | 167595 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 885 | 20 | 7 | 9 | 6.2 | COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL4299615 | 167595 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 885 | 20 | 7 | 9 | 6.2 | COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
44281450 | 99699 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 573 | 12 | 3 | 8 | 1.5 | COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL284295 | 99699 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 573 | 12 | 3 | 8 | 1.5 | COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1 | 10.1016/j.bmc.2007.01.057 | |||
44281450 | 99699 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 573 | 12 | 3 | 8 | 1.5 | COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL284295 | 99699 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 573 | 12 | 3 | 8 | 1.5 | COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1 | 10.1016/j.bmc.2007.01.057 | |||
44411584 | 10305 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 465 | 7 | 2 | 4 | 3.9 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161822 | 10305 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 465 | 7 | 2 | 4 | 3.9 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
156015766 | 177673 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 407 | 3 | ChEMBL | 523 | 7 | 3 | 7 | 1.6 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4640438 | 177673 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 407 | 3 | ChEMBL | 523 | 7 | 3 | 7 | 1.6 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1 | 10.1021/acs.jmedchem.0c00828 | |||
44411584 | 10305 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 465 | 7 | 2 | 4 | 3.9 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161822 | 10305 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 465 | 7 | 2 | 4 | 3.9 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
22888433 | 64634 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 535 | 10 | 1 | 5 | 5.9 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC1CCCCC1)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL181735 | 64634 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 535 | 10 | 1 | 5 | 5.9 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC1CCCCC1)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
44579775 | 187286 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 352 | 7 | 1 | 3 | 3.5 | Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL492230 | 187286 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 352 | 7 | 1 | 3 | 3.5 | Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1 | 10.1016/j.bmcl.2008.07.120 | |||
11258291 | 189213 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 406 | 7 | 1 | 3 | 4.5 | CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL510195 | 189213 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 406 | 7 | 1 | 3 | 4.5 | CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
44579882 | 193175 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 392 | 6 | 1 | 3 | 4.5 | CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL522426 | 193175 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 392 | 6 | 1 | 3 | 4.5 | CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1 | 10.1016/j.bmcl.2008.07.120 | |||
44450044 | 161196 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 433 | 13 | 4 | 9 | -0.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCO | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL411699 | 161196 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 433 | 13 | 4 | 9 | -0.3 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCO | 10.1016/j.bmcl.2008.03.059 | |||
56926463 | 69060 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 508 | 4 | 3 | 5 | 2.5 | CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | 10.1021/jm2007062 | |||
CHEMBL1923611 | 69060 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 508 | 4 | 3 | 5 | 2.5 | CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | 10.1021/jm2007062 | |||
172447634 | 195967 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 2502 | 79 | 37 | 38 | -13.8 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1COCC#CC#CCOC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1039/d3md00441d | |||
CHEMBL5414374 | 195967 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 2502 | 79 | 37 | 38 | -13.8 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1COCC#CC#CCOC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1039/d3md00441d | |||
145981687 | 166672 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 509 | 5 | 1 | 3 | 6.5 | COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4279987 | 166672 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 509 | 5 | 1 | 3 | 6.5 | COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
44579640 | 187002 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 354 | 7 | 1 | 4 | 3.2 | COc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL489793 | 187002 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 354 | 7 | 1 | 4 | 3.2 | COc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1 | 10.1016/j.bmcl.2008.07.120 | |||
44579686 | 187097 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 395 | 8 | 2 | 4 | 3.6 | CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(NC(C)=O)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL490614 | 187097 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 395 | 8 | 2 | 4 | 3.6 | CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(NC(C)=O)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
16203238 | 137196 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 531 | 9 | 4 | 5 | 5.2 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1 | 10.1021/jm070024h | |||
CHEMBL374757 | 137196 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 531 | 9 | 4 | 5 | 5.2 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1 | 10.1021/jm070024h | |||
44390997 | 123067 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 481 | 8 | 1 | 5 | 4.6 | CC(C)N(C)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL360891 | 123067 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 481 | 8 | 1 | 5 | 4.6 | CC(C)N(C)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL3578017 | 214228 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -3 | 2 | ChEMBL | None | None | None | CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O | 10.1021/jm501702q | |||||
23661656 | 169147 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -7 | 2 | ChEMBL | 564 | 8 | 1 | 4 | 5.3 | CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)N2CCCC2=O)CC1 | 10.1016/j.bmc.2007.05.026 | |||
CHEMBL439560 | 169147 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -7 | 2 | ChEMBL | 564 | 8 | 1 | 4 | 5.3 | CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)N2CCCC2=O)CC1 | 10.1016/j.bmc.2007.05.026 | |||
44434074 | 154763 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 501 | 12 | 3 | 9 | 1.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL399625 | 154763 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 501 | 12 | 3 | 9 | 1.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1 | 10.1016/j.bmcl.2007.07.099 | |||
44434009 | 167551 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 431 | 13 | 3 | 8 | 1.1 | CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL429799 | 167551 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 431 | 13 | 3 | 8 | 1.1 | CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2007.07.099 | |||
22867312 | 23878 | None | 0 | Rat | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 472 | 5 | 3 | 4 | 3.0 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2=O | 10.1016/s0960-894x(97)10199-8 | |||
CHEMBL13366 | 23878 | None | 0 | Rat | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 472 | 5 | 3 | 4 | 3.0 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2=O | 10.1016/s0960-894x(97)10199-8 | |||
162665952 | 182485 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 688 | 14 | 4 | 10 | 3.5 | COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL4785149 | 182485 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 688 | 14 | 4 | 10 | 3.5 | COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
44434056 | 145083 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 487 | 11 | 3 | 9 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2NS(C)(=O)=O)n1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL391088 | 145083 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 487 | 11 | 3 | 9 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2NS(C)(=O)=O)n1 | 10.1016/j.bmcl.2007.07.099 | |||
44434007 | 88609 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 390 | 10 | 2 | 9 | 0.3 | COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL235446 | 88609 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 390 | 10 | 2 | 9 | 0.3 | COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2007.07.099 | |||
156021766 | 178232 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 497 | 8 | 3 | 5 | 1.6 | Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4648355 | 178232 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 497 | 8 | 3 | 5 | 1.6 | Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44391035 | 122674 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 545 | 11 | 1 | 4 | 5.3 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1F)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL360247 | 122674 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 545 | 11 | 1 | 4 | 5.3 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1F)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
44301512 | 12026 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 566 | 13 | 3 | 8 | 1.0 | CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 | 10.1016/s0960-894x(01)00324-9 | |||
CHEMBL1183340 | 12026 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 566 | 13 | 3 | 8 | 1.0 | CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 | 10.1016/s0960-894x(01)00324-9 | |||
CHEMBL291333 | 12026 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 566 | 13 | 3 | 8 | 1.0 | CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 | 10.1016/s0960-894x(01)00324-9 | |||
145979268 | 166759 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 607 | 8 | 1 | 5 | 7.4 | COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4281647 | 166759 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 607 | 8 | 1 | 5 | 7.4 | COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
145959007 | 162351 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 436 | 4 | 4 | 5 | 2.8 | N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4163623 | 162351 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 436 | 4 | 4 | 5 | 2.8 | N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
44580030 | 187076 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 324 | 6 | 1 | 3 | 3.2 | CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL490422 | 187076 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 324 | 6 | 1 | 3 | 3.2 | CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1 | 10.1016/j.bmcl.2008.07.120 | |||
118718706 | 115443 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 587 | 11 | 4 | 6 | 5.2 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
CHEMBL3350011 | 115443 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 587 | 11 | 4 | 6 | 5.2 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
44301462 | 11266 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 623 | 15 | 4 | 9 | 0.2 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 | 10.1016/s0960-894x(01)00324-9 | |||
CHEMBL1179075 | 11266 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 623 | 15 | 4 | 9 | 0.2 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 | 10.1016/s0960-894x(01)00324-9 | |||
CHEMBL58758 | 11266 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 623 | 15 | 4 | 9 | 0.2 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 | 10.1016/s0960-894x(01)00324-9 | |||
16113800 | 137899 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 536 | 11 | 3 | 6 | 4.7 | COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1 | 10.1021/jm070024h | |||
CHEMBL375972 | 137899 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 536 | 11 | 3 | 6 | 4.7 | COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1 | 10.1021/jm070024h | |||
44391015 | 123622 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 557 | 12 | 1 | 5 | 5.2 | COc1ccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)cc1 | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL361802 | 123622 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 557 | 12 | 1 | 5 | 5.2 | COc1ccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)cc1 | 10.1016/j.bmcl.2005.02.040 | |||
162677268 | 183679 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 663 | 14 | 3 | 7 | 5.7 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL4800459 | 183679 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 663 | 14 | 3 | 7 | 5.7 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
10507433 | 16474 | None | 0 | Rat | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 578 | 13 | 3 | 6 | 3.5 | C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
CHEMBL123430 | 16474 | None | 0 | Rat | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 578 | 13 | 3 | 6 | 3.5 | C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
23730458 | 146660 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 499 | 14 | 3 | 11 | 0.8 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCn1ccnc1 | 10.1021/jm7010595 | |||
CHEMBL392296 | 146660 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 499 | 14 | 3 | 11 | 0.8 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCn1ccnc1 | 10.1021/jm7010595 | |||
44576247 | 216710 | None | 1 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
CHEMBL506986 | 216710 | None | 1 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
168285897 | 191766 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 273 | 7 | 1 | 2 | 4.1 | CCCCCCCc1cc(=O)c2cc(OC)ccc2[nH]1 | 10.1021/acs.jmedchem.1c02191 | |||
CHEMBL5196194 | 191766 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 273 | 7 | 1 | 2 | 4.1 | CCCCCCCc1cc(=O)c2cc(OC)ccc2[nH]1 | 10.1021/acs.jmedchem.1c02191 | |||
155529391 | 171543 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 1427 | 41 | 20 | 17 | -3.5 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
CHEMBL4463042 | 171543 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 1427 | 41 | 20 | 17 | -3.5 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
145956659 | 162149 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 406 | 4 | 4 | 3 | 2.4 | O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4160434 | 162149 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 406 | 4 | 4 | 3 | 2.4 | O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
155537651 | 172419 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 1597 | 47 | 22 | 19 | -3.8 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
CHEMBL4475293 | 172419 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 1597 | 47 | 22 | 19 | -3.8 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
145981196 | 166631 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 627 | 5 | 1 | 6 | 7.1 | Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4279344 | 166631 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 627 | 5 | 1 | 6 | 7.1 | Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
145979819 | 166568 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 655 | 8 | 1 | 6 | 7.9 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4278185 | 166568 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 655 | 8 | 1 | 6 | 7.9 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
44434016 | 90227 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 415 | 12 | 3 | 7 | 1.5 | CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL238228 | 90227 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 415 | 12 | 3 | 7 | 1.5 | CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2007.07.099 | |||
16113692 | 137323 | None | 1 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 559 | 11 | 4 | 5 | 5.6 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1 | 10.1021/jm070024h | |||
CHEMBL375162 | 137323 | None | 1 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 559 | 11 | 4 | 5 | 5.6 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1 | 10.1021/jm070024h | |||
24970113 | 69078 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 580 | 3 | 3 | 5 | 3.8 | C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1 | 10.1021/jm2007062 | |||
CHEMBL1923629 | 69078 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 580 | 3 | 3 | 5 | 3.8 | C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1 | 10.1021/jm2007062 | |||
CHEMBL2170777 | 211824 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | None | None | None | CCC[C@H](NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O | 10.1021/jm300414b | |||||
145956026 | 162757 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 418 | 6 | 2 | 3 | 2.9 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4169979 | 162757 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 418 | 6 | 2 | 3 | 2.9 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
22862436 | 10316 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 499 | 7 | 2 | 6 | 1.8 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161834 | 10316 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 499 | 7 | 2 | 6 | 1.8 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
10602640 | 138276 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 545 | 14 | 2 | 5 | 4.2 | CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL376970 | 138276 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 545 | 14 | 2 | 5 | 4.2 | CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO | 10.1016/j.bmc.2007.01.057 | |||
10791616 | 139623 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 503 | 11 | 1 | 4 | 5.2 | CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL379564 | 139623 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 503 | 11 | 1 | 4 | 5.2 | CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||
10029990 | 169387 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 531 | 13 | 2 | 5 | 4.0 | CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL441360 | 169387 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 531 | 13 | 2 | 5 | 4.0 | CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||
11526696 | 71626 | None | 17 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 538 | 3 | 3 | 5 | 2.6 | C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1 | nan | |||
CHEMBL1923502 | 71626 | None | 17 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 538 | 3 | 3 | 5 | 2.6 | C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1 | nan | |||
CHEMBL1963249 | 71626 | None | 17 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 538 | 3 | 3 | 5 | 2.6 | C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1 | nan | |||
10649323 | 15537 | None | 0 | Rat | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 508 | 13 | 2 | 5 | 2.5 | CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](COCc1ccccc1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
CHEMBL121803 | 15537 | None | 0 | Rat | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 508 | 13 | 2 | 5 | 2.5 | CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](COCc1ccccc1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
10841400 | 16858 | None | 0 | Rat | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 608 | 13 | 3 | 5 | 3.7 | C[C@H](O)CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
CHEMBL124831 | 16858 | None | 0 | Rat | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 608 | 13 | 3 | 5 | 3.7 | C[C@H](O)CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
156009875 | 177228 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 499 | 8 | 3 | 7 | 0.4 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4633695 | 177228 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 499 | 8 | 3 | 7 | 0.4 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44444562 | 94524 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 463 | 6 | 1 | 5 | 3.5 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)CCc1ccccc1Cl)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
CHEMBL251365 | 94524 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 463 | 6 | 1 | 5 | 3.5 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)CCc1ccccc1Cl)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
145956026 | 162757 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 418 | 6 | 2 | 3 | 2.9 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4169979 | 162757 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 418 | 6 | 2 | 3 | 2.9 | Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1 | 10.1021/acs.jmedchem.8b00322 | |||
22862436 | 10316 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 499 | 7 | 2 | 6 | 1.8 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161834 | 10316 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 499 | 7 | 2 | 6 | 1.8 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
10602640 | 138276 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 545 | 14 | 2 | 5 | 4.2 | CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL376970 | 138276 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 545 | 14 | 2 | 5 | 4.2 | CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO | 10.1016/j.bmc.2007.01.057 | |||
10791616 | 139623 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 503 | 11 | 1 | 4 | 5.2 | CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL379564 | 139623 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 503 | 11 | 1 | 4 | 5.2 | CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||
10029990 | 169387 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 531 | 13 | 2 | 5 | 4.0 | CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL441360 | 169387 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 531 | 13 | 2 | 5 | 4.0 | CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||
156009875 | 177228 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 499 | 8 | 3 | 7 | 0.4 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4633695 | 177228 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 499 | 8 | 3 | 7 | 0.4 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
156015766 | 177673 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 407 | 3 | ChEMBL | 523 | 7 | 3 | 7 | 1.6 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4640438 | 177673 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 407 | 3 | ChEMBL | 523 | 7 | 3 | 7 | 1.6 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1 | 10.1021/acs.jmedchem.0c00828 | |||
44570967 | 190278 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 437 | 4 | 2 | 6 | 1.1 | Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL517391 | 190278 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 437 | 4 | 2 | 6 | 1.1 | Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1 | 10.1016/j.bmcl.2008.12.042 | |||
24969114 | 88913 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 506 | 6 | 2 | 7 | 4.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1Cl | 10.6019/CHEMBL2364335 | |||
CHEMBL2364342 | 88913 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 506 | 6 | 2 | 7 | 4.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1Cl | 10.6019/CHEMBL2364335 | |||
59007076 | 88936 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 457 | 6 | 2 | 6 | 4.4 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364365 | 88936 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 457 | 6 | 2 | 6 | 4.4 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1 | 10.6019/CHEMBL2364335 | |||
69197196 | 88938 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 463 | 6 | 2 | 7 | 4.5 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)s1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364367 | 88938 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 463 | 6 | 2 | 7 | 4.5 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)s1 | 10.6019/CHEMBL2364335 | |||
69197071 | 88977 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 445 | 5 | 2 | 5 | 4.5 | C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364406 | 88977 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 445 | 5 | 2 | 5 | 4.5 | C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
69194482 | 88992 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 409 | 4 | 2 | 4 | 4.1 | Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364420 | 88992 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 409 | 4 | 2 | 4 | 4.1 | Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1 | 10.6019/CHEMBL2364335 | |||
11719784 | 89029 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1C | 10.6019/CHEMBL2364335 | |||
CHEMBL2364456 | 89029 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1C | 10.6019/CHEMBL2364335 | |||
59007054 | 89061 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 441 | 5 | 3 | 6 | 3.9 | Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2)o1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364487 | 89061 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 441 | 5 | 3 | 6 | 3.9 | Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2)o1 | 10.6019/CHEMBL2364335 | |||
16114097 | 79188 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 631 | 12 | 4 | 7 | 5.5 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1 | 10.1021/jm0704550 | |||
CHEMBL2113321 | 79188 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 631 | 12 | 4 | 7 | 5.5 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1 | 10.1021/jm0704550 | |||
16113710 | 79192 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 571 | 10 | 4 | 5 | 5.5 | O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1 | 10.1021/jm0704550 | |||
CHEMBL2113325 | 79192 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 571 | 10 | 4 | 5 | 5.5 | O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1 | 10.1021/jm0704550 | |||
23730226 | 147960 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 449 | 13 | 4 | 10 | -0.1 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCO | 10.1021/jm7010595 | |||
CHEMBL393329 | 147960 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 449 | 13 | 4 | 10 | -0.1 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCO | 10.1021/jm7010595 | |||
71453489 | 211827 | None | 18 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/acs.jmedchem.8b01644 | |||||
CHEMBL2170781 | 211827 | None | 18 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/acs.jmedchem.8b01644 | |||||
44411632 | 10306 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 476 | 5 | 3 | 4 | 3.6 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161823 | 10306 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 476 | 5 | 3 | 4 | 3.6 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
22888425 | 62544 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 557 | 12 | 2 | 5 | 4.7 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(CO)c1ccccc1)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL178216 | 62544 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 557 | 12 | 2 | 5 | 4.7 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(CO)c1ccccc1)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
44411632 | 10306 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 476 | 5 | 3 | 4 | 3.6 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161823 | 10306 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 476 | 5 | 3 | 4 | 3.6 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL2170782 | 211828 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
44579858 | 187031 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 415 | 7 | 2 | 4 | 3.9 | CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL490010 | 187031 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 415 | 7 | 2 | 4 | 3.9 | CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
44579778 | 187125 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 372 | 7 | 1 | 3 | 3.9 | CC(Oc1ccccc1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL490801 | 187125 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 372 | 7 | 1 | 3 | 3.9 | CC(Oc1ccccc1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
162657606 | 181223 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 693 | 15 | 3 | 8 | 5.7 | COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL4760409 | 181223 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 693 | 15 | 3 | 8 | 5.7 | COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
145956659 | 162149 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 406 | 4 | 4 | 3 | 2.4 | O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4160434 | 162149 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 406 | 4 | 4 | 3 | 2.4 | O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
145950987 | 162935 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 418 | 4 | 3 | 5 | 1.7 | Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4172848 | 162935 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 418 | 4 | 3 | 5 | 1.7 | Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21 | 10.1021/acs.jmedchem.8b00322 | |||
69198313 | 88932 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 426 | 5 | 2 | 6 | 3.2 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccnc12 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364361 | 88932 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 426 | 5 | 2 | 6 | 3.2 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccnc12 | 10.6019/CHEMBL2364335 | |||
69195692 | 88933 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 443 | 5 | 2 | 5 | 4.0 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364362 | 88933 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 443 | 5 | 2 | 5 | 4.0 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.6019/CHEMBL2364335 | |||
69196612 | 88934 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 442 | 6 | 2 | 7 | 3.3 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364363 | 88934 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 442 | 6 | 2 | 7 | 3.3 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 | 10.6019/CHEMBL2364335 | |||
11511158 | 88982 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364411 | 88982 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
69198054 | 89035 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cc(C)cs2)c1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364462 | 89035 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cc(C)cs2)c1 | 10.6019/CHEMBL2364335 | |||
69195074 | 89048 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 458 | 6 | 2 | 7 | 3.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)nc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364474 | 89048 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 458 | 6 | 2 | 7 | 3.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)nc1 | 10.6019/CHEMBL2364335 | |||
69195546 | 89058 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 459 | 5 | 2 | 5 | 4.5 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c2ccccc12 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364484 | 89058 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 459 | 5 | 2 | 5 | 4.5 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c2ccccc12 | 10.6019/CHEMBL2364335 | |||
44580028 | 193359 | None | 0 | Human | Functional | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 416 | 8 | 1 | 4 | 4.5 | COc1c(-c2ccccc2)cccc1N(C[C@H]1CCCN1)C(=O)COc1ccccc1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL523786 | 193359 | None | 0 | Human | Functional | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 416 | 8 | 1 | 4 | 4.5 | COc1c(-c2ccccc2)cccc1N(C[C@H]1CCCN1)C(=O)COc1ccccc1 | 10.1016/j.bmcl.2008.07.120 | |||
44434011 | 147952 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 465 | 12 | 3 | 8 | 1.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL393321 | 147952 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 465 | 12 | 3 | 8 | 1.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1 | 10.1016/j.bmcl.2007.07.099 | |||
57390496 | 69077 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 552 | 3 | 3 | 5 | 2.9 | Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F | 10.1021/jm2007062 | |||
CHEMBL1923628 | 69077 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 552 | 3 | 3 | 5 | 2.9 | Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F | 10.1021/jm2007062 | |||
145988894 | 167240 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 601 | 5 | 1 | 4 | 7.4 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4290680 | 167240 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 601 | 5 | 1 | 4 | 7.4 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
44434086 | 148943 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 420 | 10 | 2 | 7 | 2.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C/C=C/c2ccccc2)n1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL394130 | 148943 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 420 | 10 | 2 | 7 | 2.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C/C=C/c2ccccc2)n1 | 10.1016/j.bmcl.2007.07.099 | |||
145950987 | 162935 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 418 | 4 | 3 | 5 | 1.7 | Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4172848 | 162935 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 418 | 4 | 3 | 5 | 1.7 | Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21 | 10.1021/acs.jmedchem.8b00322 | |||
44449924 | 160039 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 487 | 12 | 4 | 9 | 1.0 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)N[C@H]1CC[C@H](O)CC1 | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL410730 | 160039 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 487 | 12 | 4 | 9 | 1.0 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)N[C@H]1CC[C@H](O)CC1 | 10.1016/j.bmcl.2008.03.059 | |||
56926785 | 69082 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 508 | 4 | 3 | 5 | 2.3 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | 10.1021/jm2007062 | |||
CHEMBL1923634 | 69082 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 508 | 4 | 3 | 5 | 2.3 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O | 10.1021/jm2007062 | |||
172462089 | 196556 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 2481 | 92 | 38 | 37 | -12.0 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C | 10.1039/d3md00441d | |||
CHEMBL5426545 | 196556 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 2481 | 92 | 38 | 37 | -12.0 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C | 10.1039/d3md00441d | |||
44434078 | 89944 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 513 | 10 | 2 | 9 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC2Cc3ccccc3N2S(C)(=O)=O)n1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL237932 | 89944 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 513 | 10 | 2 | 9 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC2Cc3ccccc3N2S(C)(=O)=O)n1 | 10.1016/j.bmcl.2007.07.099 | |||
44434008 | 146622 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 404 | 11 | 2 | 9 | 0.7 | COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL392268 | 146622 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 404 | 11 | 2 | 9 | 0.7 | COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1016/j.bmcl.2007.07.099 | |||
44411913 | 10315 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 451 | 6 | 2 | 4 | 3.5 | CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161833 | 10315 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 451 | 6 | 2 | 4 | 3.5 | CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
44268939 | 30455 | None | 0 | Rat | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 488 | 5 | 3 | 5 | 3.0 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@]2(CC(=O)c3ccccc3O2)C1 | 10.1016/s0960-894x(97)10199-8 | |||
CHEMBL13926 | 30455 | None | 0 | Rat | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 488 | 5 | 3 | 5 | 3.0 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@]2(CC(=O)c3ccccc3O2)C1 | 10.1016/s0960-894x(97)10199-8 | |||
44411913 | 10315 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 451 | 6 | 2 | 4 | 3.5 | CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161833 | 10315 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 451 | 6 | 2 | 4 | 3.5 | CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
44434015 | 88525 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 493 | 14 | 3 | 8 | 1.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL235011 | 88525 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 493 | 14 | 3 | 8 | 1.9 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1 | 10.1016/j.bmcl.2007.07.099 | |||
44411905 | 10314 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 483 | 6 | 2 | 5 | 2.2 | CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161832 | 10314 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 483 | 6 | 2 | 5 | 2.2 | CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
10506325 | 101295 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 527 | 8 | 4 | 4 | 3.9 | CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL296104 | 101295 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 527 | 8 | 4 | 4 | 3.9 | CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1 | 10.1016/j.bmc.2007.01.057 | |||
16113371 | 79184 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 587 | 11 | 4 | 6 | 5.2 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
CHEMBL2113318 | 79184 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 587 | 11 | 4 | 6 | 5.2 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
162676229 | 183410 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 715 | 15 | 3 | 10 | 3.9 | COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL4797064 | 183410 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 715 | 15 | 3 | 10 | 3.9 | COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL3578005 | 214219 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/jm501702q | |||||
44348031 | 113152 | None | 0 | Rat | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 618 | 14 | 3 | 5 | 4.3 | C[C@@H](O)CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
CHEMBL331303 | 113152 | None | 0 | Rat | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 618 | 14 | 3 | 5 | 4.3 | C[C@@H](O)CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
44411905 | 10314 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 483 | 6 | 2 | 5 | 2.2 | CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161832 | 10314 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 483 | 6 | 2 | 5 | 2.2 | CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
44437953 | 10326 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 522 | 9 | 3 | 6 | 1.5 | NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1162062 | 10326 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 522 | 9 | 3 | 6 | 1.5 | NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21 | 10.1016/j.bmc.2007.01.057 | |||
10506325 | 101295 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 527 | 8 | 4 | 4 | 3.9 | CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL296104 | 101295 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 527 | 8 | 4 | 4 | 3.9 | CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1 | 10.1016/j.bmc.2007.01.057 | |||
44436857 | 145744 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 594 | 12 | 4 | 7 | 4.6 | COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1 | 10.1021/jm0704550 | |||
CHEMBL391588 | 145744 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 594 | 12 | 4 | 7 | 4.6 | COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1 | 10.1021/jm0704550 | |||
156021787 | 178248 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 509 | 6 | 4 | 5 | 1.8 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4648799 | 178248 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 509 | 6 | 4 | 5 | 1.8 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
10006735 | 117077 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 515 | 10 | 3 | 6 | 2.0 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL33892 | 117077 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 515 | 10 | 3 | 6 | 2.0 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1 | 10.1016/j.bmc.2007.01.057 | |||
10006735 | 117077 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 515 | 10 | 3 | 6 | 2.0 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL33892 | 117077 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 515 | 10 | 3 | 6 | 2.0 | CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1 | 10.1016/j.bmc.2007.01.057 | |||
156021787 | 178248 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 509 | 6 | 4 | 5 | 1.8 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4648799 | 178248 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 509 | 6 | 4 | 5 | 1.8 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
11712108 | 161402 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 451 | 6 | 2 | 5 | 4.4 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL412303 | 161402 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 451 | 6 | 2 | 5 | 4.4 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
44571003 | 192697 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 445 | 4 | 1 | 5 | 3.0 | Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2)o1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL521439 | 192697 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 445 | 4 | 1 | 5 | 3.0 | Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2)o1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL3578005 | 214219 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/jm501702q | |||||
69196876 | 88923 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 441 | 6 | 2 | 7 | 2.9 | COc1ccc(NS(=O)(=O)c2ccc(-n3cccn3)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364352 | 88923 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 441 | 6 | 2 | 7 | 2.9 | COc1ccc(NS(=O)(=O)c2ccc(-n3cccn3)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
11562329 | 88962 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 495 | 8 | 2 | 6 | 4.5 | COCc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364391 | 88962 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 495 | 8 | 2 | 6 | 4.5 | COCc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1 | 10.6019/CHEMBL2364335 | |||
69196868 | 88966 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 427 | 5 | 2 | 5 | 4.4 | C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364395 | 88966 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 427 | 5 | 2 | 5 | 4.4 | C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
69196990 | 89022 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 480 | 6 | 2 | 6 | 4.4 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1C | 10.6019/CHEMBL2364335 | |||
CHEMBL2364449 | 89022 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 480 | 6 | 2 | 6 | 4.4 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1C | 10.6019/CHEMBL2364335 | |||
69195880 | 89039 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 485 | 6 | 2 | 6 | 5.0 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(C)c1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364466 | 89039 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 485 | 6 | 2 | 6 | 5.0 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(C)c1 | 10.6019/CHEMBL2364335 | |||
11518463 | 89042 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1cc(-c2cc(C)cs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364469 | 89042 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1cc(-c2cc(C)cs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1 | 10.6019/CHEMBL2364335 | |||
69195024 | 89066 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 461 | 5 | 3 | 6 | 4.2 | C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364492 | 89066 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 461 | 5 | 3 | 6 | 4.2 | C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
44390922 | 122212 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 557 | 12 | 1 | 5 | 5.2 | COc1cccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)c1 | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL359686 | 122212 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 557 | 12 | 1 | 5 | 5.2 | COc1cccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)c1 | 10.1016/j.bmcl.2005.02.040 | |||
23631026 | 167554 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 443 | 5 | 1 | 5 | 5.3 | Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1CC1CCCNC1 | 10.1021/jm070071+ | |||
CHEMBL429817 | 167554 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 443 | 5 | 1 | 5 | 5.3 | Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1CC1CCCNC1 | 10.1021/jm070071+ | |||
CHEMBL2170779 | 211825 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
44447842 | 95072 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 531 | 14 | 4 | 10 | 1.6 | CC(C)(N)C(=O)N[C@H](COCc1cc(Cl)cc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
CHEMBL254972 | 95072 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 531 | 14 | 4 | 10 | 1.6 | CC(C)(N)C(=O)N[C@H](COCc1cc(Cl)cc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO | 10.1016/j.bmcl.2008.02.021 | |||
44579804 | 187171 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 406 | 7 | 1 | 3 | 4.5 | CC(Oc1ccccc1Cl)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL491220 | 187171 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 406 | 7 | 1 | 3 | 4.5 | CC(Oc1ccccc1Cl)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
145948708 | 167594 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 886 | 20 | 7 | 10 | 5.2 | COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL4299606 | 167594 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 886 | 20 | 7 | 10 | 5.2 | COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
121879 | 2234 | None | 25 | Rat | Functional | pEC50 | = | 7.2 | 7.2 | 1 | 5 | ChEMBL | 509 | 7 | 3 | 6 | 3.6 | O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2 | 10.1016/s0960-894x(97)10199-8 | |||
5868 | 2234 | None | 25 | Rat | Functional | pEC50 | = | 7.2 | 7.2 | 1 | 5 | ChEMBL | 509 | 7 | 3 | 6 | 3.6 | O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2 | 10.1016/s0960-894x(97)10199-8 | |||
CHEMBL308716 | 2234 | None | 25 | Rat | Functional | pEC50 | = | 7.2 | 7.2 | 1 | 5 | ChEMBL | 509 | 7 | 3 | 6 | 3.6 | O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2 | 10.1016/s0960-894x(97)10199-8 | |||
44268996 | 166558 | None | 0 | Rat | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 458 | 5 | 3 | 3 | 3.3 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2)C1 | 10.1016/s0960-894x(97)10199-8 | |||
CHEMBL427806 | 166558 | None | 0 | Rat | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 458 | 5 | 3 | 3 | 3.3 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2)C1 | 10.1016/s0960-894x(97)10199-8 | |||
122178180 | 121328 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 1130 | 35 | 12 | 11 | 3.4 | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O | 10.1021/jm501702q | |||
CHEMBL3578009 | 121328 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 1130 | 35 | 12 | 11 | 3.4 | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O | 10.1021/jm501702q | |||
44579959 | 184378 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 358 | 6 | 1 | 3 | 3.9 | CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL483865 | 184378 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 358 | 6 | 1 | 3 | 3.9 | CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
44454117 | 155646 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 459 | 11 | 2 | 8 | 3.0 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL404336 | 155646 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 459 | 11 | 2 | 8 | 3.0 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N | 10.1016/j.bmcl.2008.01.100 | |||
162677361 | 183615 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 685 | 16 | 4 | 8 | 4.7 | COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL4799766 | 183615 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 685 | 16 | 4 | 8 | 4.7 | COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
172447634 | 195967 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 2502 | 79 | 37 | 38 | -13.8 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1COCC#CC#CCOC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1039/d3md00441d | |||
CHEMBL5414374 | 195967 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 2502 | 79 | 37 | 38 | -13.8 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1COCC#CC#CCOC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1039/d3md00441d | |||
CHEMBL2170700 | 211819 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(C(C)(C)C)cc1)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
44444570 | 154858 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 456 | 5 | 1 | 7 | 3.0 | COc1cc2c(cc1N1CCNCC1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
CHEMBL400125 | 154858 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 456 | 5 | 1 | 7 | 3.0 | COc1cc2c(cc1N1CCNCC1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
156017532 | 178013 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 511 | 8 | 3 | 5 | 2.0 | Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4645072 | 178013 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 511 | 8 | 3 | 5 | 2.0 | Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
11662746 | 97866 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 467 | 7 | 2 | 6 | 4.5 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Oc2ccccc2)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL271947 | 97866 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 467 | 7 | 2 | 6 | 4.5 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Oc2ccccc2)cc1 | 10.1016/j.bmcl.2007.12.021 | |||
122178180 | 121328 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 1130 | 35 | 12 | 11 | 3.4 | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O | 10.1021/jm501702q | |||
CHEMBL3578009 | 121328 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 1130 | 35 | 12 | 11 | 3.4 | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O | 10.1021/jm501702q | |||
CHEMBL3578007 | 214221 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)O | 10.1021/jm501702q | |||||
16750162 | 88912 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 474 | 6 | 2 | 7 | 3.8 | COc1ncc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)c(F)c1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364341 | 88912 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 474 | 6 | 2 | 7 | 3.8 | COc1ncc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)c(F)c1 | 10.6019/CHEMBL2364335 | |||
11568467 | 88922 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 443 | 5 | 2 | 5 | 4.0 | COc1ccc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364351 | 88922 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 443 | 5 | 2 | 5 | 4.0 | COc1ccc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
69197136 | 89023 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 489 | 6 | 2 | 6 | 4.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2ccccc2F)s1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364450 | 89023 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 489 | 6 | 2 | 6 | 4.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2ccccc2F)s1 | 10.6019/CHEMBL2364335 | |||
69195304 | 89037 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 455 | 4 | 2 | 4 | 3.9 | Cc1cc(S(=O)(=O)Nc2cc(N3C[C@H](C)N[C@H](C)C3)ccc2F)ccc1Br | 10.6019/CHEMBL2364335 | |||
CHEMBL2364464 | 89037 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 455 | 4 | 2 | 4 | 3.9 | Cc1cc(S(=O)(=O)Nc2cc(N3C[C@H](C)N[C@H](C)C3)ccc2F)ccc1Br | 10.6019/CHEMBL2364335 | |||
145949880 | 162886 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 390 | 6 | 3 | 3 | 2.3 | CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4172217 | 162886 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 390 | 6 | 3 | 3 | 2.3 | CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
16114099 | 137311 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 559 | 10 | 4 | 5 | 5.5 | Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1021/jm070024h | |||
CHEMBL375103 | 137311 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 559 | 10 | 4 | 5 | 5.5 | Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1021/jm070024h | |||
44269018 | 97401 | None | 0 | Rat | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 458 | 5 | 3 | 3 | 3.4 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc32)C1 | 10.1016/s0960-894x(97)10199-8 | |||
CHEMBL269447 | 97401 | None | 0 | Rat | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 458 | 5 | 3 | 3 | 3.4 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc32)C1 | 10.1016/s0960-894x(97)10199-8 | |||
145949880 | 162886 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 390 | 6 | 3 | 3 | 2.3 | CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4172217 | 162886 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 390 | 6 | 3 | 3 | 2.3 | CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.8b00322 | |||
156015598 | 177682 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 486 | 7 | 4 | 6 | 0.6 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4640573 | 177682 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 486 | 7 | 4 | 6 | 0.6 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1 | 10.1021/acs.jmedchem.0c00828 | |||
44452827 | 95479 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 453 | 5 | 2 | 7 | 3.7 | C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)ccc2C#N)C[C@@H](C)N1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL257019 | 95479 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 453 | 5 | 2 | 7 | 3.7 | C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)ccc2C#N)C[C@@H](C)N1 | 10.1016/j.bmcl.2007.12.021 | |||
46882582 | 5757 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | -125 | 2 | ChEMBL | 466 | 5 | 2 | 5 | 3.9 | CC1(C)CCc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc2O1 | 10.1016/j.bmcl.2009.09.027 | |||
CHEMBL1078490 | 5757 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | -125 | 2 | ChEMBL | 466 | 5 | 2 | 5 | 3.9 | CC1(C)CCc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc2O1 | 10.1016/j.bmcl.2009.09.027 | |||
145988647 | 167168 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 587 | 5 | 1 | 4 | 7.1 | C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4289530 | 167168 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 587 | 5 | 1 | 4 | 7.1 | C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
44454367 | 95314 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 481 | 12 | 2 | 9 | 2.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F | 10.1016/j.bmcl.2008.01.100 | |||
CHEMBL256235 | 95314 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 481 | 12 | 2 | 9 | 2.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F | 10.1016/j.bmcl.2008.01.100 | |||
16113691 | 136806 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 545 | 10 | 4 | 5 | 5.2 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1 | 10.1021/jm0704550 | |||
CHEMBL374073 | 136806 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 545 | 10 | 4 | 5 | 5.2 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1 | 10.1021/jm0704550 | |||
16113691 | 136806 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 545 | 10 | 4 | 5 | 5.2 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1 | 10.1021/jm070024h | |||
CHEMBL374073 | 136806 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 545 | 10 | 4 | 5 | 5.2 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1 | 10.1021/jm070024h | |||
22867380 | 29428 | None | 1 | Rat | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 472 | 5 | 3 | 3 | 3.8 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCCc3ccccc32)CC1 | 10.1016/s0960-894x(97)10199-8 | |||
CHEMBL13841 | 29428 | None | 1 | Rat | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 472 | 5 | 3 | 3 | 3.8 | CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCCc3ccccc32)CC1 | 10.1016/s0960-894x(97)10199-8 | |||
2098 | 3694 | None | 31 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -128 | 11 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b02122 | |||||
36511 | 3694 | None | 31 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -128 | 11 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b02122 | |||||
3805 | 3694 | None | 31 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -128 | 11 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b02122 | |||||
3835 | 3694 | None | 31 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -128 | 11 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b02122 | |||||
CHEMBL235363 | 3694 | None | 31 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -128 | 11 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b02122 | |||||
155561671 | 175768 | None | 0 | Human | Functional | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 817 | 22 | 11 | 9 | -0.5 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
CHEMBL4581511 | 175768 | None | 0 | Human | Functional | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 817 | 22 | 11 | 9 | -0.5 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
44434073 | 89634 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 501 | 12 | 3 | 9 | 1.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL237507 | 89634 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 501 | 12 | 3 | 9 | 1.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O | 10.1016/j.bmcl.2007.07.099 | |||
145981794 | 166792 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 567 | 6 | 1 | 5 | 6.6 | COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4282394 | 166792 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 567 | 6 | 1 | 5 | 6.6 | COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
56926173 | 69034 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 492 | 4 | 3 | 5 | 2.2 | CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O | 10.1021/jm1012374 | |||
CHEMBL1923501 | 69034 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 492 | 4 | 3 | 5 | 2.2 | CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O | 10.1021/jm1012374 | |||
44301389 | 11279 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 623 | 15 | 4 | 9 | 0.2 | CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 | 10.1016/s0960-894x(01)00324-9 | |||
CHEMBL1179118 | 11279 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 623 | 15 | 4 | 9 | 0.2 | CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 | 10.1016/s0960-894x(01)00324-9 | |||
CHEMBL61292 | 11279 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 623 | 15 | 4 | 9 | 0.2 | CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 | 10.1016/s0960-894x(01)00324-9 | |||
156015598 | 177682 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 486 | 7 | 4 | 6 | 0.6 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4640573 | 177682 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 486 | 7 | 4 | 6 | 0.6 | O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1 | 10.1021/acs.jmedchem.0c00828 | |||
156017532 | 178013 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 511 | 8 | 3 | 5 | 2.0 | Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4645072 | 178013 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 511 | 8 | 3 | 5 | 2.0 | Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
10100708 | 12038 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 530 | 9 | 3 | 7 | 0.3 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21 | 10.1016/s0960-894x(01)00324-9 | |||
CHEMBL1183387 | 12038 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 530 | 9 | 3 | 7 | 0.3 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21 | 10.1016/s0960-894x(01)00324-9 | |||
CHEMBL294408 | 12038 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 530 | 9 | 3 | 7 | 0.3 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21 | 10.1016/s0960-894x(01)00324-9 | |||
44579756 | 186929 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 372 | 7 | 1 | 3 | 3.9 | CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL489370 | 186929 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 372 | 7 | 1 | 3 | 3.9 | CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
145958487 | 162278 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 443 | 4 | 3 | 5 | 3.1 | Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4162545 | 162278 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 443 | 4 | 3 | 5 | 3.1 | Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21 | 10.1021/acs.jmedchem.8b00322 | |||
156016840 | 177736 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 621 | 7 | 3 | 7 | 3.4 | Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4641215 | 177736 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 621 | 7 | 3 | 7 | 3.4 | Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL2170779 | 211825 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
71453489 | 211827 | None | 18 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
CHEMBL2170781 | 211827 | None | 18 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
10209618 | 63519 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 555 | 11 | 1 | 5 | 5.4 | CC(=O)c1ccccc1C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL179978 | 63519 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 555 | 11 | 1 | 5 | 5.4 | CC(=O)c1ccccc1C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
44391041 | 64342 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 591 | 11 | 1 | 6 | 5.1 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)Cc1ccccc1)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL181123 | 64342 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 591 | 11 | 1 | 6 | 5.1 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)Cc1ccccc1)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
10600702 | 141423 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 477 | 10 | 1 | 4 | 4.7 | CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL383526 | 141423 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 477 | 10 | 1 | 4 | 4.7 | CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||
10600702 | 141423 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 477 | 10 | 1 | 4 | 4.7 | CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL383526 | 141423 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 477 | 10 | 1 | 4 | 4.7 | CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1016/j.bmc.2007.01.057 | |||
9868878 | 96594 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 460 | 14 | 4 | 9 | -0.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(N)=O | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL262884 | 96594 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 460 | 14 | 4 | 9 | -0.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(N)=O | 10.1016/j.bmcl.2008.03.059 | |||
11306502 | 63663 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 495 | 8 | 1 | 5 | 5.5 | CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL180094 | 63663 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 495 | 8 | 1 | 5 | 5.5 | CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
22888395 | 63926 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 513 | 10 | 1 | 4 | 5.2 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL180540 | 63926 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 513 | 10 | 1 | 4 | 5.2 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
156021942 | 178328 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 475 | 8 | 3 | 5 | 1.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4649860 | 178328 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 475 | 8 | 3 | 5 | 1.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
16113248 | 79195 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 560 | 11 | 3 | 5 | 5.6 | CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1 | 10.1021/jm0704550 | |||
CHEMBL2113328 | 79195 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 560 | 11 | 3 | 5 | 5.6 | CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1 | 10.1021/jm0704550 | |||
23730342 | 89936 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 511 | 13 | 4 | 10 | 1.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCc1cccc(O)c1 | 10.1021/jm7010595 | |||
CHEMBL237916 | 89936 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 511 | 13 | 4 | 10 | 1.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCc1cccc(O)c1 | 10.1021/jm7010595 | |||
145958487 | 162278 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 443 | 4 | 3 | 5 | 3.1 | Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4162545 | 162278 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 443 | 4 | 3 | 5 | 3.1 | Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21 | 10.1021/acs.jmedchem.8b00322 | |||
156010733 | 177185 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 520 | 8 | 3 | 6 | 0.2 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4633062 | 177185 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 520 | 8 | 3 | 6 | 0.2 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
156013130 | 177607 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 505 | 8 | 3 | 6 | 0.7 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4639514 | 177607 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 505 | 8 | 3 | 6 | 0.7 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
156016840 | 177736 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 621 | 7 | 3 | 7 | 3.4 | Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4641215 | 177736 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 621 | 7 | 3 | 7 | 3.4 | Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1 | 10.1021/acs.jmedchem.0c00828 | |||
156021942 | 178328 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 475 | 8 | 3 | 5 | 1.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4649860 | 178328 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 475 | 8 | 3 | 5 | 1.1 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44570920 | 184039 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 413 | 4 | 1 | 4 | 2.5 | N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL481408 | 184039 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 413 | 4 | 1 | 4 | 2.5 | N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1 | 10.1016/j.bmcl.2008.12.042 | |||
44571005 | 184153 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 431 | 4 | 1 | 5 | 2.6 | Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CCCNCC3)cc2)o1 | 10.1016/j.bmcl.2008.12.042 | |||
CHEMBL482204 | 184153 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 431 | 4 | 1 | 5 | 2.6 | Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CCCNCC3)cc2)o1 | 10.1016/j.bmcl.2008.12.042 | |||
11539144 | 88927 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 425 | 5 | 2 | 5 | 3.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364356 | 88927 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 425 | 5 | 2 | 5 | 3.8 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1 | 10.6019/CHEMBL2364335 | |||
69197315 | 88943 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 475 | 6 | 2 | 6 | 4.6 | COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364372 | 88943 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 475 | 6 | 2 | 6 | 4.6 | COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1 | 10.6019/CHEMBL2364335 | |||
11683663 | 88969 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 441 | 6 | 2 | 6 | 3.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364398 | 88969 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 441 | 6 | 2 | 6 | 3.9 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1 | 10.6019/CHEMBL2364335 | |||
11583902 | 89010 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 484 | 6 | 2 | 6 | 4.2 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1F | 10.6019/CHEMBL2364335 | |||
CHEMBL2364437 | 89010 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 484 | 6 | 2 | 6 | 4.2 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1F | 10.6019/CHEMBL2364335 | |||
69198030 | 89015 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 479 | 5 | 2 | 5 | 5.2 | C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3Cl)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364442 | 89015 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 479 | 5 | 2 | 5 | 5.2 | C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3Cl)c2)C[C@@H](C)N1 | 10.6019/CHEMBL2364335 | |||
69197149 | 89027 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)c(C)c1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364454 | 89027 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 471 | 6 | 2 | 6 | 4.7 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)c(C)c1 | 10.6019/CHEMBL2364335 | |||
69196669 | 89052 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 456 | 6 | 2 | 7 | 3.6 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)nc1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364478 | 89052 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 456 | 6 | 2 | 7 | 3.6 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)nc1 | 10.6019/CHEMBL2364335 | |||
10032659 | 12055 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 587 | 11 | 4 | 8 | -0.5 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21 | 10.1016/s0960-894x(01)00324-9 | |||
CHEMBL1183505 | 12055 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 587 | 11 | 4 | 8 | -0.5 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21 | 10.1016/s0960-894x(01)00324-9 | |||
CHEMBL301259 | 12055 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 587 | 11 | 4 | 8 | -0.5 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21 | 10.1016/s0960-894x(01)00324-9 | |||
44450137 | 96354 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 465 | 12 | 3 | 8 | 2.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)Nc1ccccc1 | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL261234 | 96354 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 465 | 12 | 3 | 8 | 2.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)Nc1ccccc1 | 10.1016/j.bmcl.2008.03.059 | |||
127046472 | 139781 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 902 | 24 | 8 | 10 | 5.6 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1 | 10.1021/acs.jmedchem.1c02191 | |||
CHEMBL3798056 | 139781 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 902 | 24 | 8 | 10 | 5.6 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1 | 10.1021/acs.jmedchem.1c02191 | |||
127046472 | 139781 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 902 | 24 | 8 | 10 | 5.6 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3798056 | 139781 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 902 | 24 | 8 | 10 | 5.6 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
145988286 | 167302 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 542 | 6 | 1 | 6 | 5.4 | COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4291718 | 167302 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 542 | 6 | 1 | 6 | 5.4 | COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL3578007 | 214221 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)O | 10.1021/jm501702q | |||||
172468931 | 197109 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 2562 | 79 | 37 | 38 | -10.6 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CSCc2ccc(cc2)CSC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1039/d3md00441d | |||
CHEMBL5438862 | 197109 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 2562 | 79 | 37 | 38 | -10.6 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CSCc2ccc(cc2)CSC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1039/d3md00441d | |||
CHEMBL61663 | 218329 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | None | None | None | CCCCCCCC(=O)OC[C@H](NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/s0960-894x(01)00324-9 | |||||
24180592 | 97066 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | 1 | 2 | ChEMBL | 560 | 11 | 1 | 4 | 5.7 | CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1 | 10.1021/jm701137s | |||
CHEMBL266647 | 97066 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | 1 | 2 | ChEMBL | 560 | 11 | 1 | 4 | 5.7 | CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1 | 10.1021/jm701137s | |||
162663868 | 182094 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 672 | 14 | 3 | 9 | 3.8 | COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL4780408 | 182094 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 672 | 14 | 3 | 9 | 3.8 | COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
145986080 | 166547 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 489 | 5 | 1 | 3 | 6.2 | COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4277793 | 166547 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 489 | 5 | 1 | 3 | 6.2 | COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
168274297 | 190688 | None | 0 | Human | Functional | pEC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 299 | 6 | 1 | 1 | 5.3 | CCCCCCCc1cc(=O)c2cc(C(C)(C)C)ccc2[nH]1 | 10.1021/acs.jmedchem.1c02191 | |||
CHEMBL5180310 | 190688 | None | 0 | Human | Functional | pEC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 299 | 6 | 1 | 1 | 5.3 | CCCCCCCc1cc(=O)c2cc(C(C)(C)C)ccc2[nH]1 | 10.1021/acs.jmedchem.1c02191 | |||
127047523 | 140150 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 859 | 20 | 7 | 9 | 6.0 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3800422 | 140150 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 859 | 20 | 7 | 9 | 6.0 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
44434118 | 148266 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 467 | 14 | 3 | 9 | 0.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNS(C)(=O)=O | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL393570 | 148266 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 467 | 14 | 3 | 9 | 0.5 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNS(C)(=O)=O | 10.1016/j.bmcl.2007.07.099 | |||
44446187 | 94674 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 611 | 11 | 3 | 7 | 6.6 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
CHEMBL252255 | 94674 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 611 | 11 | 3 | 7 | 6.6 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
145959787 | 162379 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 444 | 4 | 2 | 4 | 3.4 | CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4164107 | 162379 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 444 | 4 | 2 | 4 | 3.4 | CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
155557019 | 174691 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 1598 | 47 | 22 | 19 | -3.2 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
CHEMBL4556887 | 174691 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 1598 | 47 | 22 | 19 | -3.2 | CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.8b01644 | |||
56926893 | 69085 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 538 | 3 | 3 | 5 | 2.6 | CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1 | 10.1021/jm2007062 | |||
CHEMBL1923637 | 69085 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 538 | 3 | 3 | 5 | 2.6 | CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1 | 10.1021/jm2007062 | |||
44437963 | 204549 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 452 | 6 | 1 | 3 | 4.5 | CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL608826 | 204549 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 452 | 6 | 1 | 3 | 4.5 | CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21 | 10.1016/j.bmc.2007.01.057 | |||
172452277 | 196067 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 2504 | 79 | 37 | 36 | -10.1 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@]1(C)CCC/C=C\CCC[C@@](C)(C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1039/d3md00441d | |||
CHEMBL5416334 | 196067 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 2504 | 79 | 37 | 36 | -10.1 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@]1(C)CCC/C=C\CCC[C@@](C)(C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1039/d3md00441d | |||
44437963 | 204549 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 452 | 6 | 1 | 3 | 4.5 | CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL608826 | 204549 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 452 | 6 | 1 | 3 | 4.5 | CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21 | 10.1016/j.bmc.2007.01.057 | |||
44579881 | 186942 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 392 | 6 | 1 | 3 | 4.5 | CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL489402 | 186942 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 392 | 6 | 1 | 3 | 4.5 | CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl | 10.1016/j.bmcl.2008.07.120 | |||
24180646 | 148270 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -3 | 2 | ChEMBL | 591 | 11 | 2 | 5 | 4.7 | CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1 | 10.1021/jm701137s | |||
CHEMBL393576 | 148270 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -3 | 2 | ChEMBL | 591 | 11 | 2 | 5 | 4.7 | CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1 | 10.1021/jm701137s | |||
24180646 | 148270 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -3 | 2 | ChEMBL | 591 | 11 | 2 | 5 | 4.7 | CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1 | 10.1016/j.bmcl.2007.07.097 | |||
CHEMBL393576 | 148270 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -3 | 2 | ChEMBL | 591 | 11 | 2 | 5 | 4.7 | CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1 | 10.1016/j.bmcl.2007.07.097 | |||
145959787 | 162379 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 444 | 4 | 2 | 4 | 3.4 | CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
CHEMBL4164107 | 162379 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 444 | 4 | 2 | 4 | 3.4 | CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1 | 10.1021/acs.jmedchem.8b00322 | |||
46882520 | 5858 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -1 | 2 | ChEMBL | 430 | 5 | 2 | 4 | 3.8 | Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1Cl | 10.1016/j.bmcl.2009.09.027 | |||
CHEMBL1079311 | 5858 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -1 | 2 | ChEMBL | 430 | 5 | 2 | 4 | 3.8 | Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1Cl | 10.1016/j.bmcl.2009.09.027 | |||
46882458 | 5980 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -31 | 2 | ChEMBL | 438 | 8 | 2 | 4 | 4.2 | CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1 | 10.1016/j.bmcl.2009.09.027 | |||
CHEMBL1080046 | 5980 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -31 | 2 | ChEMBL | 438 | 8 | 2 | 4 | 4.2 | CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1 | 10.1016/j.bmcl.2009.09.027 | |||
CHEMBL3578016 | 214227 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -15 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O | 10.1021/jm501702q | |||||
59007057 | 88926 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 458 | 6 | 2 | 6 | 2.8 | COc1ccc(NS(=O)(=O)c2ccc(N3CCCC3=O)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364355 | 88926 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 458 | 6 | 2 | 6 | 2.8 | COc1ccc(NS(=O)(=O)c2ccc(N3CCCC3=O)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
11597905 | 88980 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 465 | 6 | 2 | 5 | 4.7 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364409 | 88980 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 465 | 6 | 2 | 5 | 4.7 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1 | 10.6019/CHEMBL2364335 | |||
69198135 | 89011 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 484 | 6 | 2 | 6 | 4.2 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)c(F)c1 | 10.6019/CHEMBL2364335 | |||
CHEMBL2364438 | 89011 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 484 | 6 | 2 | 6 | 4.2 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)c(F)c1 | 10.6019/CHEMBL2364335 | |||
11711997 | 89028 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 446 | 5 | 2 | 7 | 2.5 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)OCCN2C | 10.6019/CHEMBL2364335 | |||
CHEMBL2364455 | 89028 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 446 | 5 | 2 | 7 | 2.5 | COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)OCCN2C | 10.6019/CHEMBL2364335 | |||
44452778 | 159872 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 499 | 6 | 2 | 7 | 3.5 | C[C@H]1CN(c2ccc(C(=O)N(C)C)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1 | 10.1016/j.bmcl.2007.12.021 | |||
CHEMBL410527 | 159872 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 499 | 6 | 2 | 7 | 3.5 | C[C@H]1CN(c2ccc(C(=O)N(C)C)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1 | 10.1016/j.bmcl.2007.12.021 | |||
10437444 | 112944 | None | 0 | Rat | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 546 | 11 | 2 | 4 | 3.8 | CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
CHEMBL330989 | 112944 | None | 0 | Rat | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 546 | 11 | 2 | 4 | 3.8 | CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
24969603 | 69076 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 520 | 3 | 3 | 5 | 2.4 | Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1 | 10.1021/jm2007062 | |||
CHEMBL1923627 | 69076 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 520 | 3 | 3 | 5 | 2.4 | Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1 | 10.1021/jm2007062 | |||
162649450 | 180160 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 725 | 14 | 3 | 10 | 5.2 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL4747770 | 180160 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 725 | 14 | 3 | 10 | 5.2 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
156013130 | 177607 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 505 | 8 | 3 | 6 | 0.7 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4639514 | 177607 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 505 | 8 | 3 | 6 | 0.7 | Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
44450100 | 160749 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 511 | 14 | 4 | 10 | 0.6 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCO)c1 | 10.1016/j.bmcl.2008.03.059 | |||
CHEMBL411330 | 160749 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 511 | 14 | 4 | 10 | 0.6 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCO)c1 | 10.1016/j.bmcl.2008.03.059 | |||
44411720 | 10309 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 483 | 7 | 2 | 5 | 2.1 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161826 | 10309 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 483 | 7 | 2 | 5 | 2.1 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
44411902 | 10313 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 451 | 7 | 2 | 5 | 2.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161831 | 10313 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 451 | 7 | 2 | 5 | 2.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
44411720 | 10309 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 483 | 7 | 2 | 5 | 2.1 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161826 | 10309 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 483 | 7 | 2 | 5 | 2.1 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
44411902 | 10313 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 451 | 7 | 2 | 5 | 2.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
CHEMBL1161831 | 10313 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 451 | 7 | 2 | 5 | 2.4 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12 | 10.1016/j.bmc.2007.01.057 | |||
162656896 | 180966 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 669 | 14 | 3 | 8 | 5.8 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL4757313 | 180966 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 669 | 14 | 3 | 8 | 5.8 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
44436883 | 146241 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 604 | 11 | 6 | 7 | 3.6 | COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1 | 10.1021/jm0704550 | |||
CHEMBL391980 | 146241 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 604 | 11 | 6 | 7 | 3.6 | COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1 | 10.1021/jm0704550 | |||
156010733 | 177185 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 520 | 8 | 3 | 6 | 0.2 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
CHEMBL4633062 | 177185 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 520 | 8 | 3 | 6 | 0.2 | Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1 | 10.1021/acs.jmedchem.0c00828 | |||
10745674 | 168057 | None | 0 | Rat | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 572 | 13 | 3 | 5 | 3.5 | C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
CHEMBL431668 | 168057 | None | 0 | Rat | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 572 | 13 | 3 | 5 | 3.5 | C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
44579776 | 193360 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 352 | 7 | 1 | 3 | 3.5 | Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL523795 | 193360 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 352 | 7 | 1 | 3 | 3.5 | Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1 | 10.1016/j.bmcl.2008.07.120 | |||
127048061 | 139823 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 903 | 24 | 7 | 11 | 5.9 | COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3798337 | 139823 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 903 | 24 | 7 | 11 | 5.9 | COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
23730340 | 89775 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 504 | 15 | 4 | 10 | 0.4 | CC(=O)NCCCCNC(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1021/jm7010595 | |||
CHEMBL237700 | 89775 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 504 | 15 | 4 | 10 | 0.4 | CC(=O)NCCCCNC(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N | 10.1021/jm7010595 | |||
56926175 | 69035 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 494 | 4 | 3 | 5 | 2.1 | CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O | 10.1021/jm2007062 | |||
CHEMBL1923504 | 69035 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 494 | 4 | 3 | 5 | 2.1 | CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O | 10.1021/jm2007062 | |||
145992835 | 166930 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 587 | 5 | 1 | 4 | 7.1 | C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4285075 | 166930 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 587 | 5 | 1 | 4 | 7.1 | C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
56925343 | 69088 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 550 | 3 | 3 | 5 | 2.5 | C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C | 10.1021/jm2007062 | |||
CHEMBL1923640 | 69088 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 550 | 3 | 3 | 5 | 2.5 | C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C | 10.1021/jm2007062 | |||
145986870 | 167236 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 505 | 6 | 1 | 4 | 5.9 | COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4290627 | 167236 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 505 | 6 | 1 | 4 | 5.9 | COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1 | 10.1021/acs.jmedchem.8b00794 | |||
44434054 | 89338 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 487 | 11 | 3 | 9 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2cccc(NS(C)(=O)=O)c2)n1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL236857 | 89338 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 487 | 11 | 3 | 9 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2cccc(NS(C)(=O)=O)c2)n1 | 10.1016/j.bmcl.2007.07.099 | |||
44446178 | 155213 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 595 | 11 | 3 | 6 | 6.2 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
CHEMBL402023 | 155213 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 595 | 11 | 3 | 6 | 6.2 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
CHEMBL3578016 | 214227 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -15 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O | 10.1021/jm501702q | |||||
162648837 | 179944 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 706 | 15 | 3 | 8 | 5.8 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
CHEMBL4745116 | 179944 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 706 | 15 | 3 | 8 | 5.8 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1 | 10.1021/acs.jmedchem.9b02122 | |||
44391024 | 64306 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 527 | 11 | 1 | 4 | 5.2 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL180992 | 64306 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 527 | 11 | 1 | 4 | 5.2 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
10745674 | 168057 | None | 0 | Rat | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 572 | 13 | 3 | 5 | 3.5 | C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
CHEMBL431668 | 168057 | None | 0 | Rat | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 572 | 13 | 3 | 5 | 3.5 | C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N | 10.1021/jm980197u | |||
44391021 | 19460 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 569 | 12 | 1 | 5 | 5.3 | CC(=O)C(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1 | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL129637 | 19460 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 569 | 12 | 1 | 5 | 5.3 | CC(=O)C(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1 | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL2170696 | 211815 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
23730343 | 89937 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 475 | 12 | 3 | 10 | 0.7 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NC[C@H]1CCCO1 | 10.1021/jm7010595 | |||
CHEMBL237917 | 89937 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 475 | 12 | 3 | 10 | 0.7 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NC[C@H]1CCCO1 | 10.1021/jm7010595 | |||
22888359 | 63937 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 520 | 10 | 1 | 6 | 4.8 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C#N)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
CHEMBL180591 | 63937 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 520 | 10 | 1 | 6 | 4.8 | CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C#N)C(C)C | 10.1016/j.bmcl.2005.02.040 | |||
16114514 | 79189 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 571 | 10 | 4 | 5 | 5.5 | O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1 | 10.1021/jm0704550 | |||
CHEMBL2113322 | 79189 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 571 | 10 | 4 | 5 | 5.5 | O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1 | 10.1021/jm0704550 | |||
44579843 | 184859 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 358 | 6 | 1 | 3 | 3.9 | CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL485092 | 184859 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 358 | 6 | 1 | 3 | 3.9 | CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1 | 10.1016/j.bmcl.2008.07.120 | |||
44579643 | 186877 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 338 | 7 | 1 | 3 | 3.2 | CC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL488971 | 186877 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 338 | 7 | 1 | 3 | 3.2 | CC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
44579822 | 192633 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 386 | 7 | 1 | 3 | 4.2 | Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL520953 | 192633 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 386 | 7 | 1 | 3 | 4.2 | Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1 | 10.1016/j.bmcl.2008.07.120 | |||
44579755 | 187049 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 352 | 8 | 1 | 3 | 3.6 | CCC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL490186 | 187049 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 352 | 8 | 1 | 3 | 3.6 | CCC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1 | 10.1016/j.bmcl.2008.07.120 | |||
44580032 | 186940 | None | 0 | Human | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 363 | 7 | 1 | 4 | 3.3 | CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
CHEMBL489398 | 186940 | None | 0 | Human | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 363 | 7 | 1 | 4 | 3.3 | CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1 | 10.1016/j.bmcl.2008.07.120 | |||
172468931 | 197109 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 2562 | 79 | 37 | 38 | -10.6 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CSCc2ccc(cc2)CSC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1039/d3md00441d | |||
CHEMBL5438862 | 197109 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 2562 | 79 | 37 | 38 | -10.6 | CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CSCc2ccc(cc2)CSC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1039/d3md00441d | |||
145991945 | 166911 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 615 | 6 | 1 | 4 | 7.8 | CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4284715 | 166911 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 615 | 6 | 1 | 4 | 7.8 | CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1 | 10.1021/acs.jmedchem.8b00794 | |||
145992253 | 167024 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 595 | 6 | 1 | 6 | 6.4 | COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4286849 | 167024 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 595 | 6 | 1 | 6 | 6.4 | COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL2170702 | 211821 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm300414b | |||||
145993313 | 166988 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 577 | 7 | 1 | 4 | 7.4 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4286101 | 166988 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 577 | 7 | 1 | 4 | 7.4 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
16114008 | 84880 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 536 | 11 | 3 | 6 | 4.7 | COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N | 10.1021/jm070024h | |||
CHEMBL223532 | 84880 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 536 | 11 | 3 | 6 | 4.7 | COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N | 10.1021/jm070024h | |||
CHEMBL501261 | 216623 | None | 20 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O | 10.1021/acs.jmedchem.8b01644 | |||||
9848305 | 145540 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 487 | 11 | 3 | 9 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccc(NS(C)(=O)=O)cc2)n1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL391429 | 145540 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 487 | 11 | 3 | 9 | 1.2 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccc(NS(C)(=O)=O)cc2)n1 | 10.1016/j.bmcl.2007.07.099 | |||
44434050 | 145538 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 394 | 9 | 2 | 7 | 1.8 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL391428 | 145538 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 394 | 9 | 2 | 7 | 1.8 | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1 | 10.1016/j.bmcl.2007.07.099 | |||
CHEMBL3578015 | 214226 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -33 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O | 10.1021/jm501702q | |||||
CHEMBL369482 | 214623 | None | 0 | Rat | Functional | pED50 | = | 8 | 8.0 | - | 0 | ChEMBL | None | None | None | C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cn1ccnc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1016/S0960-894X(01)80239-0 | |||||
44269087 | 98280 | None | 0 | Rat | Functional | pED50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 553 | 10 | 4 | 7 | 3.2 | CC(C)(NCCCO)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O | 10.1016/S0960-894X(01)80239-0 | |||
CHEMBL274341 | 98280 | None | 0 | Rat | Functional | pED50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 553 | 10 | 4 | 7 | 3.2 | CC(C)(NCCCO)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O | 10.1016/S0960-894X(01)80239-0 | |||
70691550 | 73225 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 572 | 8 | 2 | 5 | 5.1 | Cc1cc(F)ccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2 | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011825 | 73225 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 572 | 8 | 2 | 5 | 5.1 | Cc1cc(F)ccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2 | 10.1016/j.bmcl.2012.01.014 | |||
16114292 | 96987 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 601 | 11 | 4 | 6 | 5.5 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
CHEMBL266063 | 96987 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 601 | 11 | 4 | 6 | 5.5 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
CHEMBL509976 | 218070 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O | 10.1074/jbc.m609796200 | |||||
25260901 | 113543 | None | 1 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 577 | 5 | 2 | 9 | 3.6 | CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1 | 10.1021/acs.jmedchem.1c02191 | |||
CHEMBL3319405 | 113543 | None | 1 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 577 | 5 | 2 | 9 | 3.6 | CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1 | 10.1021/acs.jmedchem.1c02191 | |||
71456897 | 81881 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 513 | 5 | 2 | 3 | 5.7 | CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164507 | 81881 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 513 | 5 | 2 | 3 | 5.7 | CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
70691551 | 73226 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 568 | 8 | 2 | 5 | 5.3 | Cc1cccc(C)c1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2 | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011826 | 73226 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 568 | 8 | 2 | 5 | 5.3 | Cc1cccc(C)c1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2 | 10.1016/j.bmcl.2012.01.014 | |||
25261382 | 113504 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 535 | 7 | 2 | 8 | 3.3 | CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1 | 10.1021/acs.jmedchem.1c02191 | |||
CHEMBL3319215 | 113504 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 535 | 7 | 2 | 8 | 3.3 | CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1 | 10.1021/acs.jmedchem.1c02191 | |||
11431274 | 77373 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 467 | 9 | 3 | 8 | 3.8 | CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL208424 | 77373 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 467 | 9 | 3 | 8 | 3.8 | CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
11577349 | 65252 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 529 | 9 | 1 | 5 | 5.7 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL182655 | 65252 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 529 | 9 | 1 | 5 | 5.7 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
11351838 | 77679 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 468 | 8 | 4 | 6 | 4.9 | CC(NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1)c1ccccc1 | 10.1021/jm060461g | |||
CHEMBL208842 | 77679 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 468 | 8 | 4 | 6 | 4.9 | CC(NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1)c1ccccc1 | 10.1021/jm060461g | |||
11712151 | 76020 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 453 | 9 | 3 | 7 | 4.8 | CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1 | 10.1021/jm0510934 | |||
CHEMBL205470 | 76020 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 453 | 9 | 3 | 7 | 4.8 | CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1 | 10.1021/jm0510934 | |||
11713497 | 123304 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 531 | 9 | 1 | 6 | 6.8 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1 | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL361349 | 123304 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 531 | 9 | 1 | 6 | 6.8 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1 | 10.1016/j.bmcl.2004.11.075 | |||
44409757 | 141411 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 506 | 8 | 3 | 8 | 4.1 | CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccc(F)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL383454 | 141411 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 506 | 8 | 3 | 8 | 4.1 | CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccc(F)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
127046807 | 140027 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 652 | 12 | 4 | 7 | 5.8 | COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3799671 | 140027 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 652 | 12 | 4 | 7 | 5.8 | COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
3676358 | 5536 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 409 | 3 | 1 | 2 | 4.4 | O=C(c1ccc(-c2ccccc2)cc1)N1CCN(C(=O)c2ccc3cc[nH]c3c2)CC1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1076586 | 5536 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 409 | 3 | 1 | 2 | 4.4 | O=C(c1ccc(-c2ccccc2)cc1)N1CCN(C(=O)c2ccc3cc[nH]c3c2)CC1 | 10.1016/j.bmcl.2010.01.043 | |||
122182047 | 122068 | None | 0 | Rat | Functional | pIC50 | = | 7 | 7.0 | -67 | 2 | ChEMBL | 588 | 8 | 2 | 7 | 5.4 | COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl | 10.1016/j.bmc.2015.05.047 | |||
CHEMBL3593636 | 122068 | None | 0 | Rat | Functional | pIC50 | = | 7 | 7.0 | -67 | 2 | ChEMBL | 588 | 8 | 2 | 7 | 5.4 | COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl | 10.1016/j.bmc.2015.05.047 | |||
122178603 | 121403 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 590 | 11 | 2 | 6 | 6.4 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581036 | 121403 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 590 | 11 | 2 | 6 | 6.4 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
11649248 | 66691 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 515 | 9 | 1 | 5 | 7.2 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL185399 | 66691 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 515 | 9 | 1 | 5 | 7.2 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
44395020 | 124099 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 507 | 9 | 1 | 5 | 6.1 | CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL363021 | 124099 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 507 | 9 | 1 | 5 | 6.1 | CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1 | 10.1016/j.bmcl.2004.06.060 | |||
44389262 | 122098 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 479 | 6 | 2 | 4 | 6.1 | Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1 | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL359506 | 122098 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 479 | 6 | 2 | 4 | 6.1 | Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1 | 10.1016/j.bmcl.2004.11.075 | |||
145993628 | 167487 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 483 | 4 | 1 | 2 | 6.1 | C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4295148 | 167487 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 483 | 4 | 1 | 2 | 6.1 | C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
11211892 | 80247 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 405 | 8 | 3 | 6 | 4.0 | CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1 | 10.1021/jm060461g | |||
CHEMBL213703 | 80247 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 405 | 8 | 3 | 6 | 4.0 | CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1 | 10.1021/jm060461g | |||
122178611 | 121412 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 572 | 11 | 3 | 7 | 5.4 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581044 | 121412 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 572 | 11 | 3 | 7 | 5.4 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
11846624 | 77945 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 490 | 6 | 2 | 8 | 4.3 | CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1 | 10.1021/jm060461g | |||
CHEMBL209443 | 77945 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 490 | 6 | 2 | 8 | 4.3 | CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1 | 10.1021/jm060461g | |||
11846463 | 139329 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 422 | 5 | 2 | 8 | 2.7 | CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1 | 10.1021/jm060461g | |||
CHEMBL378909 | 139329 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 422 | 5 | 2 | 8 | 2.7 | CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1 | 10.1021/jm060461g | |||
11430392 | 76752 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 431 | 6 | 3 | 7 | 3.5 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1 | 10.1021/jm0510934 | |||
CHEMBL206588 | 76752 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 431 | 6 | 3 | 7 | 3.5 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1 | 10.1021/jm0510934 | |||
57797614 | 73217 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 558 | 8 | 2 | 5 | 4.8 | CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011817 | 73217 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 558 | 8 | 2 | 5 | 4.8 | CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
44409801 | 76761 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 425 | 5 | 3 | 7 | 3.6 | CC(C)(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL206638 | 76761 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 425 | 5 | 3 | 7 | 3.6 | CC(C)(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
11523411 | 75582 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 363 | 6 | 4 | 6 | 3.5 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1 | 10.1021/jm0510934 | |||
CHEMBL204511 | 75582 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 363 | 6 | 4 | 6 | 3.5 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1 | 10.1021/jm0510934 | |||
11537800 | 75594 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 361 | 6 | 3 | 6 | 3.7 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1 | 10.1021/jm0510934 | |||
CHEMBL204564 | 75594 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 361 | 6 | 3 | 6 | 3.7 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1 | 10.1021/jm0510934 | |||
71453392 | 81878 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 514 | 5 | 2 | 4 | 4.2 | CN(C)[C@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164504 | 81878 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 514 | 5 | 2 | 4 | 4.2 | CN(C)[C@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1 | 10.1016/j.bmc.2012.07.018 | |||
71456910 | 81932 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 480 | 5 | 2 | 4 | 3.6 | CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164823 | 81932 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 480 | 5 | 2 | 4 | 3.6 | CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
71460578 | 81939 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 466 | 4 | 2 | 4 | 3.2 | CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)ccc32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164830 | 81939 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 466 | 4 | 2 | 4 | 3.2 | CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)ccc32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
122178612 | 121413 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 572 | 11 | 2 | 6 | 4.9 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581045 | 121413 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 572 | 11 | 2 | 6 | 4.9 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL507636 | 216921 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CC(=O)O)C(N)=O | 10.1074/jbc.m609796200 | |||||
56942387 | 139749 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 579 | 13 | 4 | 7 | 4.0 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3797857 | 139749 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 579 | 13 | 4 | 7 | 4.0 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
145991822 | 167055 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 587 | 5 | 1 | 4 | 6.8 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4287267 | 167055 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 587 | 5 | 1 | 4 | 6.8 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
11676995 | 66183 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 461 | 9 | 1 | 5 | 5.9 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL184258 | 66183 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 461 | 9 | 1 | 5 | 5.9 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
127048038 | 140059 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 551 | 11 | 4 | 7 | 4.2 | COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3799862 | 140059 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 551 | 11 | 4 | 7 | 4.2 | COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
71458746 | 81868 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 446 | 4 | 2 | 4 | 2.9 | Cc1ccc2c(c1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164493 | 81868 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 446 | 4 | 2 | 4 | 2.9 | Cc1ccc2c(c1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2 | 10.1016/j.bmc.2012.07.018 | |||
145992142 | 166867 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 475 | 4 | 2 | 3 | 5.9 | Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4283858 | 166867 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 475 | 4 | 2 | 3 | 5.9 | Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1 | 10.1021/acs.jmedchem.8b00794 | |||
71460565 | 81870 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 446 | 4 | 2 | 4 | 2.9 | Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1cccc(Cl)c1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164495 | 81870 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 446 | 4 | 2 | 4 | 2.9 | Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1cccc(Cl)c1 | 10.1016/j.bmc.2012.07.018 | |||
11538533 | 75027 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 397 | 6 | 3 | 7 | 2.9 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1021/jm0510934 | |||
CHEMBL203280 | 75027 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 397 | 6 | 3 | 7 | 2.9 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1021/jm0510934 | |||
46880462 | 6269 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 453 | 4 | 1 | 3 | 4.8 | COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1081648 | 6269 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 453 | 4 | 1 | 3 | 4.8 | COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)c1 | 10.1016/j.bmcl.2010.01.043 | |||
70693641 | 73228 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 538 | 8 | 2 | 5 | 4.4 | O=C1CN([C@@H](C(=O)NC2CCN(Cc3ccccc3)CC2)C2CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1 | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011828 | 73228 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 538 | 8 | 2 | 5 | 4.4 | O=C1CN([C@@H](C(=O)NC2CCN(Cc3ccccc3)CC2)C2CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1 | 10.1016/j.bmcl.2012.01.014 | |||
44409756 | 76795 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 492 | 8 | 4 | 8 | 4.1 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL206820 | 76795 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 492 | 8 | 4 | 8 | 4.1 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
46865987 | 7599 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 442 | 3 | 1 | 3 | 4.4 | C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1087908 | 7599 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 442 | 3 | 1 | 3 | 4.4 | C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
46880772 | 5913 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 424 | 3 | 1 | 3 | 4.2 | C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1079624 | 5913 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 424 | 3 | 1 | 3 | 4.2 | C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
11538534 | 75040 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 397 | 6 | 3 | 7 | 2.9 | CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1021/jm0510934 | |||
CHEMBL203373 | 75040 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 397 | 6 | 3 | 7 | 2.9 | CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1021/jm0510934 | |||
145986870 | 167236 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 505 | 6 | 1 | 4 | 5.9 | COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4290627 | 167236 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 505 | 6 | 1 | 4 | 5.9 | COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1 | 10.1021/acs.jmedchem.8b00794 | |||
127046806 | 140020 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 638 | 13 | 4 | 7 | 5.4 | COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3799604 | 140020 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 638 | 13 | 4 | 7 | 5.4 | COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
122178613 | 121414 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 625 | 12 | 2 | 7 | 6.3 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581046 | 121414 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 625 | 12 | 2 | 7 | 6.3 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
145981196 | 166631 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 627 | 5 | 1 | 6 | 7.1 | Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4279344 | 166631 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 627 | 5 | 1 | 6 | 7.1 | Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
46880814 | 6379 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 413 | 3 | 2 | 3 | 3.5 | C[C@H]1CN(C(=O)c2ccc(-c3cn[nH]c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1082190 | 6379 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 413 | 3 | 2 | 3 | 3.5 | C[C@H]1CN(C(=O)c2ccc(-c3cn[nH]c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
122178616 | 121416 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 606 | 11 | 2 | 6 | 6.9 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581048 | 121416 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 606 | 11 | 2 | 6 | 6.9 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
145986461 | 167309 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 601 | 5 | 1 | 4 | 7.4 | Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4291926 | 167309 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 601 | 5 | 1 | 4 | 7.4 | Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
71451551 | 81882 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 460 | 5 | 2 | 4 | 3.3 | CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164508 | 81882 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 460 | 5 | 2 | 4 | 3.3 | CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
46880727 | 6147 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 458 | 3 | 1 | 3 | 4.9 | C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1080939 | 6147 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 458 | 3 | 1 | 3 | 4.9 | C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
122182190 | 122075 | None | 0 | Rat | Functional | pIC50 | = | 7.9 | 7.9 | -8 | 2 | ChEMBL | 507 | 7 | 3 | 6 | 4.7 | Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F | 10.1016/j.bmc.2015.05.047 | |||
CHEMBL3593815 | 122075 | None | 0 | Rat | Functional | pIC50 | = | 7.9 | 7.9 | -8 | 2 | ChEMBL | 507 | 7 | 3 | 6 | 4.7 | Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F | 10.1016/j.bmc.2015.05.047 | |||
44409840 | 76369 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 500 | 7 | 3 | 8 | 3.9 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc43)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL205896 | 76369 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 500 | 7 | 3 | 8 | 3.9 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc43)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
127047362 | 139806 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 590 | 11 | 5 | 7 | 4.7 | COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3798204 | 139806 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 590 | 11 | 5 | 7 | 4.7 | COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
145989916 | 166842 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 491 | 5 | 2 | 4 | 5.6 | COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(O)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4283454 | 166842 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 491 | 5 | 2 | 4 | 5.6 | COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(O)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
127048038 | 140059 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 551 | 11 | 4 | 7 | 4.2 | COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3799862 | 140059 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 551 | 11 | 4 | 7 | 4.2 | COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
46880673 | 6107 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 507 | 4 | 1 | 3 | 5.7 | C[C@H]1CN(C(=O)c2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1080755 | 6107 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 507 | 4 | 1 | 3 | 5.7 | C[C@H]1CN(C(=O)c2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
11455251 | 161408 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 523 | 8 | 3 | 7 | 5.0 | Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1 | 10.1021/jm060461g | |||
CHEMBL412362 | 161408 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 523 | 8 | 3 | 7 | 5.0 | Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1 | 10.1021/jm060461g | |||
44409611 | 74713 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 463 | 6 | 3 | 7 | 4.2 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC4CCC3C4)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL203019 | 74713 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 463 | 6 | 3 | 7 | 4.2 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC4CCC3C4)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
11221946 | 140933 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 353 | 5 | 3 | 5 | 4.1 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1 | 10.1021/jm0510934 | |||
CHEMBL381942 | 140933 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 353 | 5 | 3 | 5 | 4.1 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1 | 10.1021/jm0510934 | |||
44409839 | 76285 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 412 | 7 | 4 | 8 | 2.0 | CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL205847 | 76285 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 412 | 7 | 4 | 8 | 2.0 | CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
71460576 | 81936 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 466 | 4 | 2 | 4 | 3.2 | CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3c(Cl)cc(Cl)cc32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164828 | 81936 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 466 | 4 | 2 | 4 | 3.2 | CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3c(Cl)cc(Cl)cc32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL509976 | 218070 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O | 10.1074/jbc.m609796200 | |||||
11692087 | 63012 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 517 | 9 | 1 | 6 | 6.4 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL178610 | 63012 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 517 | 9 | 1 | 6 | 6.4 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
44409758 | 76001 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 411 | 6 | 3 | 7 | 3.4 | CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL205374 | 76001 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 411 | 6 | 3 | 7 | 3.4 | CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
44409661 | 76023 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 423 | 6 | 3 | 7 | 3.6 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCC3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL205484 | 76023 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 423 | 6 | 3 | 7 | 3.6 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCC3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
46880724 | 6260 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 437 | 3 | 1 | 2 | 5.1 | Cc1cc(-c2ccccc2)ccc1C(=O)N1CCN(C(=O)c2ccc3cc[nH]c3c2)[C@@H](C)C1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1081611 | 6260 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 437 | 3 | 1 | 2 | 5.1 | Cc1cc(-c2ccccc2)ccc1C(=O)N1CCN(C(=O)c2ccc3cc[nH]c3c2)[C@@H](C)C1 | 10.1016/j.bmcl.2010.01.043 | |||
71455105 | 81935 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 432 | 4 | 2 | 4 | 2.6 | CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)ccc32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164827 | 81935 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 432 | 4 | 2 | 4 | 2.6 | CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)ccc32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
11221946 | 140933 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 353 | 5 | 3 | 5 | 4.1 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1 | 10.1021/jm060461g | |||
CHEMBL381942 | 140933 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 353 | 5 | 3 | 5 | 4.1 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1 | 10.1021/jm060461g | |||
44410003 | 76208 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 468 | 10 | 4 | 8 | 3.5 | CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL205794 | 76208 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 468 | 10 | 4 | 8 | 3.5 | CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
46880811 | 6000 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 424 | 3 | 1 | 3 | 4.2 | C[C@H]1CN(C(=O)c2ccc(-c3cccnc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1080162 | 6000 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 424 | 3 | 1 | 3 | 4.2 | C[C@H]1CN(C(=O)c2ccc(-c3cccnc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
70687379 | 73223 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 570 | 9 | 2 | 6 | 4.7 | COc1cccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)c1 | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011823 | 73223 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 570 | 9 | 2 | 6 | 4.7 | COc1cccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)c1 | 10.1016/j.bmcl.2012.01.014 | |||
44394974 | 67033 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 515 | 9 | 1 | 5 | 7.1 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL186974 | 67033 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 515 | 9 | 1 | 5 | 7.1 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL3586019 | 214261 | None | 5 | Rat | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O | 10.1016/j.bmcl.2015.04.040 | |||||
46880567 | 6389 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 441 | 3 | 1 | 2 | 5.0 | C[C@H]1CN(C(=O)c2ccc(-c3cccc(F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1082210 | 6389 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 441 | 3 | 1 | 2 | 5.0 | C[C@H]1CN(C(=O)c2ccc(-c3cccc(F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
71460564 | 81867 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 488 | 4 | 2 | 4 | 3.9 | CN1CCN(CC(=O)NC2(c3ccc(C(C)(C)C)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164492 | 81867 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 488 | 4 | 2 | 4 | 3.9 | CN1CCN(CC(=O)NC2(c3ccc(C(C)(C)C)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
145992854 | 166962 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 587 | 5 | 1 | 4 | 7.0 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4285747 | 166962 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 587 | 5 | 1 | 4 | 7.0 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
44394833 | 126893 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 542 | 9 | 1 | 5 | 6.7 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL365460 | 126893 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 542 | 9 | 1 | 5 | 6.7 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL509976 | 218070 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O | 10.1074/jbc.m609796200 | |||||
CHEMBL509976 | 218070 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O | 10.1074/jbc.m609796200 | |||||
CHEMBL509976 | 218070 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O | 10.1074/jbc.m609796200 | |||||
127047654 | 140064 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 571 | 11 | 3 | 7 | 5.2 | COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3799883 | 140064 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 571 | 11 | 3 | 7 | 5.2 | COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
145993758 | 167412 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 490 | 5 | 2 | 4 | 5.4 | COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(N)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4294024 | 167412 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 490 | 5 | 2 | 4 | 5.4 | COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(N)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
145993528 | 167414 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 561 | 5 | 1 | 4 | 6.6 | C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4294083 | 167414 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 561 | 5 | 1 | 4 | 6.6 | C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL444131 | 216390 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | None | None | None | NC(=O)CNC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12 | 10.1074/jbc.m609796200 | |||||
11476589 | 76015 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 456 | 9 | 3 | 8 | 4.5 | Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm0510934 | |||
CHEMBL205451 | 76015 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 456 | 9 | 3 | 8 | 4.5 | Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm0510934 | |||
11329138 | 64481 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 481 | 9 | 1 | 5 | 5.1 | CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1 | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL181350 | 64481 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 481 | 9 | 1 | 5 | 5.1 | CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1 | 10.1016/j.bmcl.2012.01.014 | |||
70681022 | 73232 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 568 | 8 | 2 | 5 | 5.4 | CC(C)[C@H](C(=O)N1CCC(NC(C)(C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011833 | 73232 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 568 | 8 | 2 | 5 | 5.4 | CC(C)[C@H](C(=O)N1CCC(NC(C)(C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL509976 | 218070 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O | 10.1074/jbc.m609796200 | |||||
122178611 | 121412 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 572 | 11 | 3 | 7 | 5.4 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581044 | 121412 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 572 | 11 | 3 | 7 | 5.4 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
46880675 | 6145 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 441 | 3 | 1 | 2 | 5.0 | C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2F)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1080927 | 6145 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 441 | 3 | 1 | 2 | 5.0 | C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2F)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
11612155 | 141096 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 451 | 8 | 3 | 7 | 5.4 | Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm0510934 | |||
CHEMBL382375 | 141096 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 451 | 8 | 3 | 7 | 5.4 | Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm0510934 | |||
328912 | 62596 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 505 | 5 | 1 | 4 | 7.0 | Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL178266 | 62596 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 505 | 5 | 1 | 4 | 7.0 | Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C | 10.1016/j.bmcl.2004.11.075 | |||
70685218 | 73220 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 574 | 8 | 2 | 5 | 5.3 | CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3cccc(Cl)c3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011820 | 73220 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 574 | 8 | 2 | 5 | 5.3 | CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3cccc(Cl)c3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
145981794 | 166792 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 567 | 6 | 1 | 5 | 6.6 | COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4282394 | 166792 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 567 | 6 | 1 | 5 | 6.6 | COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
11649239 | 66361 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 514 | 9 | 1 | 5 | 5.9 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL185057 | 66361 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 514 | 9 | 1 | 5 | 5.9 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL501261 | 216623 | None | 20 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O | 10.1074/jbc.m609796200 | |||||
1744826 | 63018 | None | 15 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 417 | 6 | 1 | 4 | 6.1 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL178668 | 63018 | None | 15 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 417 | 6 | 1 | 4 | 6.1 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
11282247 | 166021 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 445 | 8 | 3 | 6 | 5.3 | Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm060461g | |||
CHEMBL425048 | 166021 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 445 | 8 | 3 | 6 | 5.3 | Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm060461g | |||
11282247 | 166021 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 445 | 8 | 3 | 6 | 5.3 | Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm0510934 | |||
CHEMBL425048 | 166021 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 445 | 8 | 3 | 6 | 5.3 | Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm0510934 | |||
1744826 | 63018 | None | 15 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 417 | 6 | 1 | 4 | 6.1 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL178668 | 63018 | None | 15 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 417 | 6 | 1 | 4 | 6.1 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
44409831 | 75725 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 503 | 6 | 3 | 9 | 3.8 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3COc4ccccc4O3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL204776 | 75725 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 503 | 6 | 3 | 9 | 3.8 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3COc4ccccc4O3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
145979268 | 166759 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 607 | 8 | 1 | 5 | 7.4 | COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4281647 | 166759 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 607 | 8 | 1 | 5 | 7.4 | COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
44409678 | 141304 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 490 | 9 | 3 | 9 | 3.4 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL382853 | 141304 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 490 | 9 | 3 | 9 | 3.4 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
11349789 | 78804 | None | 1 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 389 | 7 | 3 | 6 | 3.4 | Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm060461g | |||
CHEMBL211265 | 78804 | None | 1 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 389 | 7 | 3 | 6 | 3.4 | Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm060461g | |||
11692087 | 63012 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 517 | 9 | 1 | 6 | 6.4 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL178610 | 63012 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 517 | 9 | 1 | 6 | 6.4 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
11677781 | 125125 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 502 | 9 | 1 | 5 | 5.8 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL364430 | 125125 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 502 | 9 | 1 | 5 | 5.8 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
11538533 | 75027 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 397 | 6 | 3 | 7 | 2.9 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1021/jm060461g | |||
CHEMBL203280 | 75027 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 397 | 6 | 3 | 7 | 2.9 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1021/jm060461g | |||
11154823 | 76056 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 436 | 8 | 3 | 7 | 4.5 | N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1 | 10.1021/jm0510934 | |||
CHEMBL205660 | 76056 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 436 | 8 | 3 | 7 | 4.5 | N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1 | 10.1021/jm0510934 | |||
56942244 | 125264 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 632 | 12 | 5 | 7 | 4.9 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3645259 | 125264 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 632 | 12 | 5 | 7 | 4.9 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
44409994 | 76209 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 409 | 6 | 3 | 7 | 3.2 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL205796 | 76209 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 409 | 6 | 3 | 7 | 3.2 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
44576247 | 216710 | None | 1 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1074/jbc.m609796200 | |||||
CHEMBL506986 | 216710 | None | 1 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1074/jbc.m609796200 | |||||
44395002 | 66207 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 534 | 9 | 1 | 5 | 5.6 | CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL184368 | 66207 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 534 | 9 | 1 | 5 | 5.6 | CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1 | 10.1016/j.bmcl.2004.06.060 | |||
11646276 | 75961 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 364 | 6 | 3 | 7 | 3.4 | CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1 | 10.1021/jm0510934 | |||
CHEMBL205136 | 75961 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 364 | 6 | 3 | 7 | 3.4 | CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1 | 10.1021/jm0510934 | |||
127046807 | 140027 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 652 | 12 | 4 | 7 | 5.8 | COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3799671 | 140027 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 652 | 12 | 4 | 7 | 5.8 | COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
16113695 | 137114 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 575 | 11 | 4 | 6 | 5.2 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
CHEMBL374643 | 137114 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 575 | 11 | 4 | 6 | 5.2 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
145987684 | 167373 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 615 | 6 | 1 | 4 | 7.8 | CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4293331 | 167373 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 615 | 6 | 1 | 4 | 7.8 | CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
122178602 | 121402 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 634 | 11 | 2 | 6 | 6.5 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581035 | 121402 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 634 | 11 | 2 | 6 | 6.5 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
70681020 | 73229 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 540 | 8 | 2 | 5 | 4.7 | CC(C)[C@@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011829 | 73229 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 540 | 8 | 2 | 5 | 4.7 | CC(C)[C@@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
56942098 | 125260 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 613 | 12 | 3 | 7 | 5.3 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3645255 | 125260 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 613 | 12 | 3 | 7 | 5.3 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
56942242 | 125262 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 566 | 12 | 4 | 7 | 3.6 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3645257 | 125262 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 566 | 12 | 4 | 7 | 3.6 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
127046956 | 140044 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 631 | 12 | 3 | 7 | 5.5 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3799776 | 140044 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 631 | 12 | 3 | 7 | 5.5 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
66788278 | 125259 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 652 | 12 | 4 | 7 | 5.8 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3645254 | 125259 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 652 | 12 | 4 | 7 | 5.8 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
127046956 | 140044 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 631 | 12 | 3 | 7 | 5.5 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3799776 | 140044 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 631 | 12 | 3 | 7 | 5.5 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
57797640 | 73251 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 510 | 9 | 1 | 3 | 7.1 | CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCCc2ccc(Oc3ccc(F)cc3F)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011892 | 73251 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 510 | 9 | 1 | 3 | 7.1 | CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCCc2ccc(Oc3ccc(F)cc3F)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
46880628 | 6034 | None | 0 | Rat | Functional | pIC50 | = | 8.7 | 8.7 | 4 | 2 | ChEMBL | 441 | 3 | 1 | 2 | 5.0 | C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1080389 | 6034 | None | 0 | Rat | Functional | pIC50 | = | 8.7 | 8.7 | 4 | 2 | ChEMBL | 441 | 3 | 1 | 2 | 5.0 | C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
122178606 | 121406 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 574 | 11 | 2 | 6 | 5.8 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581039 | 121406 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 574 | 11 | 2 | 6 | 5.8 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
46880629 | 6060 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 457 | 3 | 1 | 2 | 5.5 | C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1080556 | 6060 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 457 | 3 | 1 | 2 | 5.5 | C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
122178606 | 121406 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 574 | 11 | 2 | 6 | 5.8 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581039 | 121406 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 574 | 11 | 2 | 6 | 5.8 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
70681021 | 73231 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 554 | 8 | 2 | 5 | 5.2 | CC(C)[C@H](C(=O)N1CCC(N[C@H](C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011832 | 73231 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 554 | 8 | 2 | 5 | 5.2 | CC(C)[C@H](C(=O)N1CCC(N[C@H](C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
70691552 | 73233 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 560 | 8 | 2 | 5 | 5.4 | CC(C)[C@H](C(=O)N1CCC(N[C@H](C)C2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011834 | 73233 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 560 | 8 | 2 | 5 | 5.4 | CC(C)[C@H](C(=O)N1CCC(N[C@H](C)C2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
44576247 | 216710 | None | 1 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1074/jbc.m609796200 | |||||
CHEMBL506986 | 216710 | None | 1 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1074/jbc.m609796200 | |||||
122178607 | 121408 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 592 | 11 | 2 | 6 | 6.0 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581040 | 121408 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 592 | 11 | 2 | 6 | 6.0 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
46880631 | 6137 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 437 | 3 | 1 | 2 | 5.1 | Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1080907 | 6137 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 437 | 3 | 1 | 2 | 5.1 | Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1 | 10.1016/j.bmcl.2010.01.043 | |||
46880726 | 6146 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 424 | 3 | 1 | 3 | 4.2 | C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1080938 | 6146 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 424 | 3 | 1 | 3 | 4.2 | C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
70689441 | 73250 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 525 | 9 | 2 | 4 | 6.1 | CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011891 | 73250 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 525 | 9 | 2 | 4 | 6.1 | CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
145988582 | 167387 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 555 | 4 | 1 | 2 | 7.4 | Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#C[Si](C)(C)C)c(Cl)c2Cl)CC1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4293608 | 167387 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 555 | 4 | 1 | 2 | 7.4 | Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#C[Si](C)(C)C)c(Cl)c2Cl)CC1 | 10.1021/acs.jmedchem.8b00794 | |||
122178610 | 121411 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 571 | 11 | 3 | 7 | 5.3 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581043 | 121411 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 571 | 11 | 3 | 7 | 5.3 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
44409666 | 75914 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 437 | 6 | 3 | 7 | 4.0 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCC3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL204897 | 75914 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 437 | 6 | 3 | 7 | 4.0 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCC3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
44576247 | 216710 | None | 1 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1074/jbc.m609796200 | |||||
CHEMBL506986 | 216710 | None | 1 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1074/jbc.m609796200 | |||||
CHEMBL500703 | 216608 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCNC(=N)N)C(N)=O | 10.1074/jbc.m609796200 | |||||
44409802 | 76772 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 439 | 9 | 3 | 7 | 4.1 | CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL206687 | 76772 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 439 | 9 | 3 | 7 | 4.1 | CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
122178613 | 121414 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 625 | 12 | 2 | 7 | 6.3 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581046 | 121414 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 625 | 12 | 2 | 7 | 6.3 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
71458747 | 81869 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 446 | 4 | 2 | 4 | 2.9 | Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164494 | 81869 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 446 | 4 | 2 | 4 | 2.9 | Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2012.07.018 | |||
56942244 | 125264 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 632 | 12 | 5 | 7 | 4.9 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3645259 | 125264 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 632 | 12 | 5 | 7 | 4.9 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
11537683 | 75554 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 354 | 5 | 3 | 6 | 3.5 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1 | 10.1021/jm0510934 | |||
CHEMBL204352 | 75554 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 354 | 5 | 3 | 6 | 3.5 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1 | 10.1021/jm0510934 | |||
71449740 | 81871 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 480 | 4 | 2 | 4 | 3.5 | Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164497 | 81871 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 480 | 4 | 2 | 4 | 3.5 | Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmc.2012.07.018 | |||
122178601 | 121401 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 634 | 11 | 2 | 6 | 6.5 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581034 | 121401 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 634 | 11 | 2 | 6 | 6.5 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
11337482 | 76668 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 364 | 6 | 3 | 7 | 3.4 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1 | 10.1021/jm0510934 | |||
CHEMBL206399 | 76668 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 364 | 6 | 3 | 7 | 3.4 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1 | 10.1021/jm0510934 | |||
122178614 | 121415 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 660 | 13 | 2 | 7 | 6.9 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581047 | 121415 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 660 | 13 | 2 | 7 | 6.9 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
44389168 | 64894 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 457 | 4 | 1 | 4 | 5.8 | Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1 | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL182154 | 64894 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 457 | 4 | 1 | 4 | 5.8 | Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1 | 10.1016/j.bmcl.2004.11.075 | |||
145991389 | 167100 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 601 | 6 | 1 | 6 | 6.5 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4288108 | 167100 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 601 | 6 | 1 | 6 | 6.5 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
145990051 | 167051 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 499 | 5 | 1 | 2 | 7.0 | Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C3CC3)c(Cl)c2Cl)CC1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4287218 | 167051 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 499 | 5 | 1 | 2 | 7.0 | Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C3CC3)c(Cl)c2Cl)CC1 | 10.1021/acs.jmedchem.8b00794 | |||
44410012 | 138486 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 439 | 9 | 3 | 7 | 4.1 | CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL377305 | 138486 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 439 | 9 | 3 | 7 | 4.1 | CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
71462272 | 81876 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 528 | 5 | 2 | 4 | 4.6 | CN(C)C1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164502 | 81876 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 528 | 5 | 2 | 4 | 4.6 | CN(C)C1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
71451563 | 81941 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 500 | 4 | 2 | 4 | 3.9 | CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164832 | 81941 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 500 | 4 | 2 | 4 | 3.9 | CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
145988286 | 167302 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 542 | 6 | 1 | 6 | 5.4 | COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4291718 | 167302 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 542 | 6 | 1 | 6 | 5.4 | COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
46880813 | 6378 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 442 | 3 | 1 | 4 | 4.4 | Cc1noc(C)c1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1082189 | 6378 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 442 | 3 | 1 | 4 | 4.4 | Cc1noc(C)c1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1 | 10.1016/j.bmcl.2010.01.043 | |||
44409761 | 75893 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 453 | 9 | 3 | 7 | 4.4 | CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL204880 | 75893 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 453 | 9 | 3 | 7 | 4.4 | CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
11846625 | 77913 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 498 | 6 | 2 | 8 | 4.3 | CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1 | 10.1021/jm060461g | |||
CHEMBL209394 | 77913 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 498 | 6 | 2 | 8 | 4.3 | CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1 | 10.1021/jm060461g | |||
122178610 | 121411 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 571 | 11 | 3 | 7 | 5.3 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581043 | 121411 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 571 | 11 | 3 | 7 | 5.3 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
46880461 | 6237 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 439 | 4 | 1 | 3 | 4.4 | COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)CC3)cc2)c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1081483 | 6237 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 439 | 4 | 1 | 3 | 4.4 | COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)CC3)cc2)c1 | 10.1016/j.bmcl.2010.01.043 | |||
71453391 | 81877 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 514 | 5 | 2 | 4 | 4.2 | CN(C)[C@@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164503 | 81877 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 514 | 5 | 2 | 4 | 4.2 | CN(C)[C@@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1 | 10.1016/j.bmc.2012.07.018 | |||
1221269 | 122100 | None | 9 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 383 | 6 | 1 | 4 | 5.4 | CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL359530 | 122100 | None | 9 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 383 | 6 | 1 | 4 | 5.4 | CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
44389151 | 62525 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 445 | 6 | 1 | 4 | 5.7 | CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL178138 | 62525 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 445 | 6 | 1 | 4 | 5.7 | CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C | 10.1016/j.bmcl.2004.11.075 | |||
71451564 | 81943 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 446 | 4 | 2 | 4 | 2.9 | Cc1cc2c(cc1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164834 | 81943 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 446 | 4 | 2 | 4 | 2.9 | Cc1cc2c(cc1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2 | 10.1016/j.bmc.2012.07.018 | |||
71449753 | 81933 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 465 | 4 | 2 | 3 | 4.7 | CC1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164825 | 81933 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 465 | 4 | 2 | 3 | 4.7 | CC1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
44409871 | 75422 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 426 | 7 | 3 | 8 | 2.4 | CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL203948 | 75422 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 426 | 7 | 3 | 8 | 2.4 | CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
46880569 | 6191 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 453 | 4 | 1 | 3 | 4.8 | COc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1081212 | 6191 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 453 | 4 | 1 | 3 | 4.8 | COc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1 | 10.1016/j.bmcl.2010.01.043 | |||
70693640 | 73222 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 570 | 9 | 2 | 6 | 4.7 | COc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2 | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011822 | 73222 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 570 | 9 | 2 | 6 | 4.7 | COc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2 | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL449590 | 216424 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(N)=O | 10.1074/jbc.m609796200 | |||||
44576247 | 216710 | None | 1 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1074/jbc.m609796200 | |||||
CHEMBL506986 | 216710 | None | 1 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1074/jbc.m609796200 | |||||
145994299 | 167492 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 523 | 5 | 1 | 4 | 6.1 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3cccc(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4295212 | 167492 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 523 | 5 | 1 | 4 | 6.1 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3cccc(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
71460577 | 81937 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 500 | 4 | 2 | 4 | 3.9 | CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)c(Cl)c32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164829 | 81937 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 500 | 4 | 2 | 4 | 3.9 | CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)c(Cl)c32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
16113902 | 137763 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 536 | 11 | 3 | 6 | 4.7 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
CHEMBL375859 | 137763 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 536 | 11 | 3 | 6 | 4.7 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
71462274 | 81880 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 528 | 5 | 2 | 4 | 3.8 | CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1=O | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164506 | 81880 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 528 | 5 | 2 | 4 | 3.8 | CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1=O | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL509976 | 218070 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O | 10.1074/jbc.m609796200 | |||||
70683143 | 73221 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 574 | 8 | 2 | 5 | 5.3 | CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(Cl)cc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011821 | 73221 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 574 | 8 | 2 | 5 | 5.3 | CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(Cl)cc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
46880495 | 6371 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 453 | 4 | 1 | 3 | 4.8 | COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@@H]3C)cc2)c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1082162 | 6371 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 453 | 4 | 1 | 3 | 4.8 | COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@@H]3C)cc2)c1 | 10.1016/j.bmcl.2010.01.043 | |||
11697618 | 62619 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 427 | 6 | 1 | 4 | 5.5 | CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL178289 | 62619 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 427 | 6 | 1 | 4 | 5.5 | CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
145988557 | 167356 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 523 | 4 | 1 | 2 | 6.9 | Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4292914 | 167356 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 523 | 4 | 1 | 2 | 6.9 | Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1 | 10.1021/acs.jmedchem.8b00794 | |||
44409771 | 141340 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 461 | 6 | 3 | 7 | 4.0 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CC4C=CC3C4)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL383073 | 141340 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 461 | 6 | 3 | 7 | 4.0 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CC4C=CC3C4)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
145980333 | 166676 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 577 | 6 | 1 | 4 | 7.5 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4280040 | 166676 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 577 | 6 | 1 | 4 | 7.5 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
11329138 | 64481 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 481 | 9 | 1 | 5 | 5.1 | CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1 | 10.1021/jm0491750 | |||
CHEMBL181350 | 64481 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 481 | 9 | 1 | 5 | 5.1 | CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1 | 10.1021/jm0491750 | |||
44576247 | 216710 | None | 1 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1074/jbc.m609796200 | |||||
CHEMBL506986 | 216710 | None | 1 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1074/jbc.m609796200 | |||||
11568561 | 169657 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 447 | 7 | 1 | 5 | 6.1 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1 | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL443560 | 169657 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 447 | 7 | 1 | 5 | 6.1 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1 | 10.1016/j.bmcl.2004.11.075 | |||
145991945 | 166911 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 615 | 6 | 1 | 4 | 7.8 | CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4284715 | 166911 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 615 | 6 | 1 | 4 | 7.8 | CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1 | 10.1021/acs.jmedchem.8b00794 | |||
44394982 | 66159 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 523 | 9 | 1 | 6 | 5.7 | CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL184093 | 66159 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 523 | 9 | 1 | 6 | 5.7 | CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1 | 10.1016/j.bmcl.2004.06.060 | |||
66788278 | 125259 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 652 | 12 | 4 | 7 | 5.8 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3645254 | 125259 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 652 | 12 | 4 | 7 | 5.8 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
56942099 | 125261 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 599 | 13 | 3 | 7 | 5.0 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3645256 | 125261 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 599 | 13 | 3 | 7 | 5.0 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
56942243 | 125263 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 621 | 12 | 4 | 8 | 3.6 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3645258 | 125263 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 621 | 12 | 4 | 8 | 3.6 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
127045858 | 139949 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 618 | 12 | 3 | 7 | 5.3 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3799225 | 139949 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 618 | 12 | 3 | 7 | 5.3 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
70681018 | 73219 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 554 | 8 | 2 | 5 | 5.0 | Cc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2 | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011819 | 73219 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 554 | 8 | 2 | 5 | 5.0 | Cc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2 | 10.1016/j.bmcl.2012.01.014 | |||
70685225 | 73253 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 576 | 8 | 2 | 5 | 5.0 | CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011894 | 73253 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 576 | 8 | 2 | 5 | 5.0 | CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
11410373 | 138622 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 558 | 10 | 4 | 8 | 4.2 | Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL377514 | 138622 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 558 | 10 | 4 | 8 | 4.2 | Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1 | 10.1016/j.bmcl.2006.01.012 | |||
11339816 | 76034 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 446 | 8 | 3 | 7 | 4.7 | Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm0510934 | |||
CHEMBL205521 | 76034 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 446 | 8 | 3 | 7 | 4.7 | Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm0510934 | |||
145992253 | 167024 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 595 | 6 | 1 | 6 | 6.4 | COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4286849 | 167024 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 595 | 6 | 1 | 6 | 6.4 | COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
11503585 | 65225 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 461 | 9 | 2 | 5 | 5.7 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL182542 | 65225 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 461 | 9 | 2 | 5 | 5.7 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
44409762 | 75913 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 441 | 9 | 4 | 8 | 2.7 | CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL204884 | 75913 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 441 | 9 | 4 | 8 | 2.7 | CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
122180026 | 121651 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 8 | 2 | ChEMBL | 566 | 7 | 2 | 7 | 4.4 | CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2 | 10.1016/j.bmcl.2015.04.040 | |||
CHEMBL3586032 | 121651 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 8 | 2 | ChEMBL | 566 | 7 | 2 | 7 | 4.4 | CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2 | 10.1016/j.bmcl.2015.04.040 | |||
46880846 | 7614 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 442 | 3 | 1 | 3 | 4.4 | C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1088038 | 7614 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 442 | 3 | 1 | 3 | 4.4 | C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
44389248 | 122234 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 433 | 7 | 2 | 5 | 5.0 | CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL359714 | 122234 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 433 | 7 | 2 | 5 | 5.0 | CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
70695749 | 73235 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 562 | 9 | 2 | 6 | 4.3 | CC(C)[C@H](C(=O)N1CCC(NCCC2CCOCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011836 | 73235 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 562 | 9 | 2 | 6 | 4.3 | CC(C)[C@H](C(=O)N1CCC(NCCC2CCOCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
122178614 | 121415 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 660 | 13 | 2 | 7 | 6.9 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581047 | 121415 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 660 | 13 | 2 | 7 | 6.9 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
70695748 | 73227 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 498 | 7 | 2 | 5 | 3.7 | O=C1CN(CC(=O)NC2CCN(Cc3ccccc3)CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1 | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011827 | 73227 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 498 | 7 | 2 | 5 | 3.7 | O=C1CN(CC(=O)NC2CCN(Cc3ccccc3)CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1 | 10.1016/j.bmcl.2012.01.014 | |||
145981687 | 166672 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 509 | 5 | 1 | 3 | 6.5 | COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4279987 | 166672 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 509 | 5 | 1 | 3 | 6.5 | COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
11508639 | 76562 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 353 | 5 | 3 | 5 | 4.1 | CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1 | 10.1021/jm0510934 | |||
CHEMBL206091 | 76562 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 353 | 5 | 3 | 5 | 4.1 | CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1 | 10.1021/jm0510934 | |||
44409683 | 76286 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 480 | 9 | 4 | 8 | 3.6 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL205848 | 76286 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 480 | 9 | 4 | 8 | 3.6 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
11626181 | 124448 | None | 1 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 431 | 7 | 1 | 4 | 6.3 | CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL363896 | 124448 | None | 1 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 431 | 7 | 1 | 4 | 6.3 | CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
11690097 | 76700 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 411 | 6 | 2 | 7 | 2.9 | CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1021/jm0510934 | |||
CHEMBL206446 | 76700 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 411 | 6 | 2 | 7 | 2.9 | CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1021/jm0510934 | |||
44409775 | 76052 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 425 | 8 | 3 | 7 | 3.7 | CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL205605 | 76052 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 425 | 8 | 3 | 7 | 3.7 | CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
44576247 | 216710 | None | 1 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1074/jbc.m609796200 | |||||
CHEMBL506986 | 216710 | None | 1 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1074/jbc.m609796200 | |||||
11655355 | 74447 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 451 | 8 | 3 | 7 | 5.4 | Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm0510934 | |||
CHEMBL202642 | 74447 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 451 | 8 | 3 | 7 | 5.4 | Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm0510934 | |||
127047654 | 140064 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 571 | 11 | 3 | 7 | 5.2 | COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3799883 | 140064 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 571 | 11 | 3 | 7 | 5.2 | COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
16113799 | 168816 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 605 | 12 | 4 | 7 | 5.2 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1 | 10.1016/j.bmcl.2007.10.113 | |||
CHEMBL436849 | 168816 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 605 | 12 | 4 | 7 | 5.2 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1 | 10.1016/j.bmcl.2007.10.113 | |||
145986080 | 166547 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 489 | 5 | 1 | 3 | 6.2 | COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4277793 | 166547 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 489 | 5 | 1 | 3 | 6.2 | COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl | 10.1021/acs.jmedchem.8b00794 | |||
56942385 | 125265 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 618 | 13 | 5 | 7 | 4.5 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3645260 | 125265 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 618 | 13 | 5 | 7 | 4.5 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
46880771 | 5912 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 448 | 3 | 1 | 4 | 4.4 | C[C@H]1CN(C(=O)c2csc(-c3ccccc3F)n2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1079623 | 5912 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 448 | 3 | 1 | 4 | 4.4 | C[C@H]1CN(C(=O)c2csc(-c3ccccc3F)n2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
11654867 | 76228 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 429 | 7 | 3 | 5 | 5.4 | Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1 | 10.1021/jm0510934 | |||
CHEMBL205833 | 76228 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 429 | 7 | 3 | 5 | 5.4 | Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1 | 10.1021/jm0510934 | |||
122178600 | 121400 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 556 | 11 | 2 | 6 | 5.7 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581033 | 121400 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 556 | 11 | 2 | 6 | 5.7 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
46880844 | 7598 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 432 | 3 | 1 | 4 | 3.0 | C[C@H]1CN(C(=O)c2ccc(N3CCOCC3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1087907 | 7598 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 432 | 3 | 1 | 4 | 3.0 | C[C@H]1CN(C(=O)c2ccc(N3CCOCC3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
11248021 | 139342 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 454 | 8 | 4 | 6 | 4.3 | Nc1nc(N)c(-c2ccc(NC(=O)NCc3ccccc3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm060461g | |||
CHEMBL378989 | 139342 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 454 | 8 | 4 | 6 | 4.3 | Nc1nc(N)c(-c2ccc(NC(=O)NCc3ccccc3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm060461g | |||
122182189 | 122074 | None | 0 | Rat | Functional | pIC50 | = | 7.5 | 7.5 | -7 | 2 | ChEMBL | 548 | 8 | 3 | 7 | 4.3 | COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl | 10.1016/j.bmc.2015.05.047 | |||
CHEMBL3593814 | 122074 | None | 0 | Rat | Functional | pIC50 | = | 7.5 | 7.5 | -7 | 2 | ChEMBL | 548 | 8 | 3 | 7 | 4.3 | COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl | 10.1016/j.bmc.2015.05.047 | |||
44409865 | 140805 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 500 | 7 | 3 | 8 | 3.8 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3Cc4ccccc4C3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL381759 | 140805 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 500 | 7 | 3 | 8 | 3.8 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3Cc4ccccc4C3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
11751384 | 141593 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 453 | 9 | 3 | 6 | 4.6 | Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm060461g | |||
CHEMBL384524 | 141593 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 453 | 9 | 3 | 6 | 4.6 | Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm060461g | |||
44409679 | 75535 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 466 | 8 | 4 | 8 | 3.4 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL204322 | 75535 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 466 | 8 | 4 | 8 | 3.4 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
44409868 | 76770 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 487 | 9 | 3 | 7 | 4.9 | CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL206673 | 76770 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 487 | 9 | 3 | 7 | 4.9 | CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
44409667 | 75996 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 451 | 6 | 3 | 7 | 4.4 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCCC3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL205294 | 75996 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 451 | 6 | 3 | 7 | 4.4 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCCC3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
44576247 | 216710 | None | 1 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1074/jbc.m609796200 | |||||
CHEMBL506986 | 216710 | None | 1 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1074/jbc.m609796200 | |||||
56942388 | 140030 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 613 | 12 | 3 | 7 | 5.3 | COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3799687 | 140030 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 613 | 12 | 3 | 7 | 5.3 | COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
11166495 | 75577 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 437 | 8 | 2 | 7 | 4.5 | N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1 | 10.1021/jm0510934 | |||
CHEMBL204474 | 75577 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 437 | 8 | 2 | 7 | 4.5 | N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1 | 10.1021/jm0510934 | |||
145994050 | 167441 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 615 | 6 | 1 | 6 | 7.1 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4294493 | 167441 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 615 | 6 | 1 | 6 | 7.1 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
11538533 | 75027 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 397 | 6 | 3 | 7 | 2.9 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL203280 | 75027 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 397 | 6 | 3 | 7 | 2.9 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
46880770 | 5911 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 458 | 3 | 1 | 3 | 4.9 | C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cn2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1079622 | 5911 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 458 | 3 | 1 | 3 | 4.9 | C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cn2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
71453390 | 81874 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 526 | 6 | 2 | 4 | 4.4 | C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164500 | 81874 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 526 | 6 | 2 | 4 | 4.4 | C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
44409763 | 141452 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 487 | 6 | 3 | 8 | 4.0 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3Cc4ccccc4O3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL383757 | 141452 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 487 | 6 | 3 | 8 | 4.0 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3Cc4ccccc4O3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
44409989 | 165921 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 467 | 11 | 3 | 7 | 4.8 | CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL424860 | 165921 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 467 | 11 | 3 | 7 | 4.8 | CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
44410008 | 141338 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 453 | 9 | 2 | 7 | 4.2 | CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL383058 | 141338 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 453 | 9 | 2 | 7 | 4.2 | CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
11178309 | 79932 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 445 | 8 | 3 | 7 | 4.3 | Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm060461g | |||
CHEMBL212415 | 79932 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 445 | 8 | 3 | 7 | 4.3 | Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm060461g | |||
11517629 | 168441 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 431 | 6 | 1 | 4 | 6.4 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1 | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL434330 | 168441 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 431 | 6 | 1 | 4 | 6.4 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1 | 10.1016/j.bmcl.2004.11.075 | |||
127047655 | 139701 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 571 | 11 | 3 | 7 | 5.2 | COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3797531 | 139701 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 571 | 11 | 3 | 7 | 5.2 | COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
127046957 | 139794 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 649 | 12 | 3 | 7 | 5.6 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3798155 | 139794 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 649 | 12 | 3 | 7 | 5.6 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
127045858 | 139949 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 618 | 12 | 3 | 7 | 5.3 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3799225 | 139949 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 618 | 12 | 3 | 7 | 5.3 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
56942098 | 125260 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 613 | 12 | 3 | 7 | 5.3 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3645255 | 125260 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 613 | 12 | 3 | 7 | 5.3 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
127046957 | 139794 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 649 | 12 | 3 | 7 | 5.6 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3798155 | 139794 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 649 | 12 | 3 | 7 | 5.6 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
46880630 | 6100 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 491 | 3 | 1 | 2 | 5.8 | C[C@H]1CN(C(=O)c2ccc(-c3ccccc3C(F)(F)F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1080735 | 6100 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 491 | 3 | 1 | 2 | 5.8 | C[C@H]1CN(C(=O)c2ccc(-c3ccccc3C(F)(F)F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
70685219 | 73234 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 560 | 9 | 2 | 5 | 5.4 | CC(C)[C@H](C(=O)N1CCC(NCCC2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011835 | 73234 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 560 | 9 | 2 | 5 | 5.4 | CC(C)[C@H](C(=O)N1CCC(NCCC2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
16113245 | 121398 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 556 | 11 | 2 | 6 | 5.7 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581030 | 121398 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 556 | 11 | 2 | 6 | 5.7 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
122178607 | 121408 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 592 | 11 | 2 | 6 | 6.0 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581040 | 121408 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 592 | 11 | 2 | 6 | 6.0 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
11452801 | 139385 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 417 | 7 | 3 | 6 | 4.2 | Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm060461g | |||
CHEMBL379191 | 139385 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 417 | 7 | 3 | 6 | 4.2 | Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm060461g | |||
46882763 | 5630 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 612 | 17 | 6 | 7 | 5.2 | CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1 | 10.1016/j.bmcl.2009.08.076 | |||
CHEMBL1077617 | 5630 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 612 | 17 | 6 | 7 | 5.2 | CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1 | 10.1016/j.bmcl.2009.08.076 | |||
44409776 | 77172 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 425 | 7 | 3 | 7 | 3.5 | CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL207754 | 77172 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 425 | 7 | 3 | 7 | 3.5 | CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
145991797 | 167012 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 613 | 5 | 1 | 6 | 6.5 | Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)NCc4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4286597 | 167012 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 613 | 5 | 1 | 6 | 6.5 | Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)NCc4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
122178616 | 121416 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 606 | 11 | 2 | 6 | 6.9 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581048 | 121416 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 606 | 11 | 2 | 6 | 6.9 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
11430583 | 80248 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 439 | 8 | 3 | 6 | 4.2 | Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm060461g | |||
CHEMBL213704 | 80248 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 439 | 8 | 3 | 6 | 4.2 | Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm060461g | |||
CHEMBL509976 | 218070 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O | 10.1074/jbc.m609796200 | |||||
11669486 | 64635 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 445 | 7 | 1 | 4 | 6.6 | CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL181736 | 64635 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 445 | 7 | 1 | 4 | 6.6 | CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C | 10.1016/j.bmcl.2004.11.075 | |||
44409946 | 139902 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 514 | 7 | 3 | 8 | 3.9 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc4C3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL379887 | 139902 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 514 | 7 | 3 | 8 | 3.9 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc4C3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
127046806 | 140020 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 638 | 13 | 4 | 7 | 5.4 | COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3799604 | 140020 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 638 | 13 | 4 | 7 | 5.4 | COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
122178600 | 121400 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 556 | 11 | 2 | 6 | 5.7 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581033 | 121400 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 556 | 11 | 2 | 6 | 5.7 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
11605333 | 76753 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 475 | 6 | 3 | 7 | 3.6 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1 | 10.1021/jm0510934 | |||
CHEMBL206589 | 76753 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 475 | 6 | 3 | 7 | 3.6 | CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1 | 10.1021/jm0510934 | |||
46880845 | 7613 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 460 | 3 | 1 | 3 | 4.5 | C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1088037 | 7613 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 460 | 3 | 1 | 3 | 4.5 | C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
46880773 | 6209 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 424 | 3 | 1 | 3 | 4.2 | C[C@H]1CN(C(=O)c2ccc(-c3ccccn3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1081301 | 6209 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 424 | 3 | 1 | 3 | 4.2 | C[C@H]1CN(C(=O)c2ccc(-c3ccccn3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
122178604 | 121404 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 571 | 11 | 3 | 7 | 5.3 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581037 | 121404 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 571 | 11 | 3 | 7 | 5.3 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
56942387 | 139749 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 579 | 13 | 4 | 7 | 4.0 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3797857 | 139749 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 579 | 13 | 4 | 7 | 4.0 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
44576247 | 216710 | None | 1 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1074/jbc.m609796200 | |||||
CHEMBL506986 | 216710 | None | 1 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1074/jbc.m609796200 | |||||
11683469 | 76734 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 433 | 6 | 3 | 7 | 3.2 | CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1 | 10.1021/jm0510934 | |||
CHEMBL206486 | 76734 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 433 | 6 | 3 | 7 | 3.2 | CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1 | 10.1021/jm0510934 | |||
44389216 | 123921 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 442 | 6 | 1 | 5 | 5.9 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1 | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL362595 | 123921 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 442 | 6 | 1 | 5 | 5.9 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1 | 10.1016/j.bmcl.2004.11.075 | |||
145979819 | 166568 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 655 | 8 | 1 | 6 | 7.9 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4278185 | 166568 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 655 | 8 | 1 | 6 | 7.9 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
46880498 | 5997 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 507 | 4 | 1 | 3 | 5.7 | C[C@H]1CN(C(=O)c2ccc(-c3cccc(OC(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1080155 | 5997 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 507 | 4 | 1 | 3 | 5.7 | C[C@H]1CN(C(=O)c2ccc(-c3cccc(OC(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
71462273 | 81879 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 513 | 5 | 2 | 3 | 5.7 | CCN1CCCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164505 | 81879 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 513 | 5 | 2 | 3 | 5.7 | CCN1CCCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1 | 10.1016/j.bmc.2012.07.018 | |||
71453404 | 81934 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 466 | 4 | 2 | 4 | 3.2 | CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164826 | 81934 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 466 | 4 | 2 | 4 | 3.2 | CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
44389283 | 62965 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 403 | 5 | 1 | 4 | 5.7 | CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL178494 | 62965 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 403 | 5 | 1 | 4 | 5.7 | CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
11179347 | 77382 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 490 | 9 | 2 | 8 | 4.0 | CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1 | 10.1021/jm0510934 | |||
CHEMBL208477 | 77382 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 490 | 9 | 2 | 8 | 4.0 | CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1 | 10.1021/jm0510934 | |||
44409764 | 77178 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 488 | 9 | 4 | 8 | 3.6 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL207792 | 77178 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 488 | 9 | 4 | 8 | 3.6 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
11606121 | 64597 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 523 | 6 | 2 | 6 | 5.9 | Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2 | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL181584 | 64597 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 523 | 6 | 2 | 6 | 5.9 | Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2 | 10.1016/j.bmcl.2004.11.075 | |||
11539587 | 67098 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 445 | 8 | 1 | 4 | 6.7 | CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL187271 | 67098 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 445 | 8 | 1 | 4 | 6.7 | CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL3586019 | 214261 | None | 5 | Rat | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O | 10.1016/j.bmcl.2015.04.040 | |||||
122178608 | 121409 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 570 | 11 | 2 | 6 | 6.0 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581041 | 121409 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 570 | 11 | 2 | 6 | 6.0 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
44409821 | 76064 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 564 | 10 | 4 | 8 | 4.2 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL205711 | 76064 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 564 | 10 | 4 | 8 | 4.2 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
11340044 | 141422 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 456 | 9 | 3 | 8 | 4.5 | Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm0510934 | |||
CHEMBL383522 | 141422 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 456 | 9 | 3 | 8 | 4.5 | Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm0510934 | |||
70683149 | 73248 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 504 | 8 | 2 | 5 | 3.9 | CC(C)[C@H](C(=O)N1CCC(NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011887 | 73248 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 504 | 8 | 2 | 5 | 3.9 | CC(C)[C@H](C(=O)N1CCC(NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
71452183 | 83562 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 538 | 5 | 4 | 6 | 1.7 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O | 10.1021/jm1012374 | |||
CHEMBL2203623 | 83562 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 538 | 5 | 4 | 6 | 1.7 | CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O | 10.1021/jm1012374 | |||
122178602 | 121402 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 634 | 11 | 2 | 6 | 6.5 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581035 | 121402 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 634 | 11 | 2 | 6 | 6.5 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
11582836 | 62933 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 431 | 7 | 1 | 4 | 6.4 | CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL178463 | 62933 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 431 | 7 | 1 | 4 | 6.4 | CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
44389192 | 168749 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 471 | 4 | 1 | 4 | 6.2 | Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1 | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL436275 | 168749 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 471 | 4 | 1 | 4 | 6.2 | Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1 | 10.1016/j.bmcl.2004.11.075 | |||
71455106 | 81944 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 442 | 5 | 2 | 5 | 2.2 | COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(C)cc32)cc1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164835 | 81944 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 442 | 5 | 2 | 5 | 2.2 | COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(C)cc32)cc1 | 10.1016/j.bmc.2012.07.018 | |||
44409998 | 138623 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 413 | 7 | 3 | 8 | 2.5 | COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL377515 | 138623 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 413 | 7 | 3 | 8 | 2.5 | COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
145984632 | 166486 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 629 | 5 | 1 | 4 | 8.0 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4276775 | 166486 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 629 | 5 | 1 | 4 | 8.0 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
10415364 | 126835 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | -5 | 3 | ChEMBL | 557 | 9 | 1 | 6 | 6.5 | CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL365294 | 126835 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | -5 | 3 | ChEMBL | 557 | 9 | 1 | 6 | 6.5 | CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1 | 10.1016/j.bmcl.2004.06.060 | |||
15949382 | 74874 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 439 | 6 | 3 | 8 | 3.2 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CCCO3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL203158 | 74874 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 439 | 6 | 3 | 8 | 3.2 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CCCO3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
145993313 | 166988 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 577 | 7 | 1 | 4 | 7.4 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4286101 | 166988 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 577 | 7 | 1 | 4 | 7.4 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
11605822 | 124455 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 503 | 9 | 1 | 6 | 6.1 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL363930 | 124455 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 503 | 9 | 1 | 6 | 6.1 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
11154001 | 79919 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 406 | 7 | 4 | 6 | 3.6 | CC(C)NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1 | 10.1021/jm060461g | |||
CHEMBL212354 | 79919 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 406 | 7 | 4 | 6 | 3.6 | CC(C)NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1 | 10.1021/jm060461g | |||
44394930 | 66353 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 551 | 9 | 1 | 6 | 7.3 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL185028 | 66353 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 551 | 9 | 1 | 6 | 7.3 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
11699004 | 66224 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 501 | 9 | 1 | 5 | 6.9 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL184429 | 66224 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 501 | 9 | 1 | 5 | 6.9 | CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1 | 10.1016/j.bmcl.2004.06.060 | |||
11618705 | 167034 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 423 | 6 | 1 | 4 | 5.3 | CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1 | 10.1016/j.bmcl.2004.06.060 | |||
CHEMBL428698 | 167034 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 423 | 6 | 1 | 4 | 5.3 | CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1 | 10.1016/j.bmcl.2004.06.060 | |||
44409785 | 75830 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 439 | 6 | 3 | 8 | 3.2 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CCCO3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL204852 | 75830 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 439 | 6 | 3 | 8 | 3.2 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CCCO3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
44409990 | 76544 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 481 | 12 | 3 | 7 | 5.2 | CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL205995 | 76544 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 481 | 12 | 3 | 7 | 5.2 | CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
145992125 | 166846 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 552 | 5 | 2 | 5 | 6.2 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4283504 | 166846 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 552 | 5 | 2 | 5 | 6.2 | Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
46880568 | 6390 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 423 | 3 | 1 | 2 | 4.8 | C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1082211 | 6390 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 423 | 3 | 1 | 2 | 4.8 | C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
70687383 | 73249 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 525 | 9 | 2 | 4 | 6.6 | CC(C)[C@H](C[C@H]1CC[C@@H](NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011890 | 73249 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 525 | 9 | 2 | 4 | 6.6 | CC(C)[C@H](C[C@H]1CC[C@@H](NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
16113245 | 121398 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 556 | 11 | 2 | 6 | 5.7 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581030 | 121398 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 556 | 11 | 2 | 6 | 5.7 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL509976 | 218070 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O | 10.1074/jbc.m609796200 | |||||
57422817 | 113512 | None | 18 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 620 | 8 | 2 | 10 | 3.2 | CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1 | 10.1021/acs.jmedchem.1c02191 | |||
CHEMBL3319223 | 113512 | None | 18 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 620 | 8 | 2 | 10 | 3.2 | CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1 | 10.1021/acs.jmedchem.1c02191 | |||
11190594 | 76012 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 469 | 10 | 3 | 8 | 3.9 | CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL205445 | 76012 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 469 | 10 | 3 | 8 | 3.9 | CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
56942385 | 125265 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 618 | 13 | 5 | 7 | 4.5 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3645260 | 125265 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 618 | 13 | 5 | 7 | 4.5 | COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
44576247 | 216710 | None | 1 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1074/jbc.m609796200 | |||||
CHEMBL506986 | 216710 | None | 1 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1074/jbc.m609796200 | |||||
16113904 | 137123 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 550 | 12 | 3 | 6 | 5.1 | COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
CHEMBL374655 | 137123 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 550 | 12 | 3 | 6 | 5.1 | COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2007.10.113 | |||
44389215 | 63098 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 383 | 6 | 1 | 4 | 5.4 | CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL178838 | 63098 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 383 | 6 | 1 | 4 | 5.4 | CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
44576247 | 216710 | None | 1 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1074/jbc.m609796200 | |||||
CHEMBL506986 | 216710 | None | 1 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1074/jbc.m609796200 | |||||
44409809 | 75091 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 453 | 10 | 3 | 7 | 4.4 | CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL203578 | 75091 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 453 | 10 | 3 | 7 | 4.4 | CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
16113468 | 141887 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 605 | 12 | 4 | 7 | 5.2 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1 | 10.1016/j.bmcl.2007.10.113 | |||
CHEMBL386218 | 141887 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 605 | 12 | 4 | 7 | 5.2 | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1 | 10.1016/j.bmcl.2007.10.113 | |||
11531313 | 62524 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 394 | 7 | 1 | 6 | 4.7 | CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL178137 | 62524 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 394 | 7 | 1 | 6 | 4.7 | CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
44389167 | 123925 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 425 | 7 | 1 | 4 | 6.4 | CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL362612 | 123925 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 425 | 7 | 1 | 4 | 6.4 | CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
46880674 | 6144 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 441 | 3 | 1 | 2 | 5.0 | C[C@H]1CN(C(=O)c2ccc(-c3ccc(F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1080926 | 6144 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 441 | 3 | 1 | 2 | 5.0 | C[C@H]1CN(C(=O)c2ccc(-c3ccc(F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
71455085 | 81875 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 514 | 4 | 2 | 4 | 4.3 | CN1CCCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164501 | 81875 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 514 | 4 | 2 | 4 | 4.3 | CN1CCCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
46880463 | 6270 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 453 | 4 | 1 | 3 | 4.8 | COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@H](C)C3)cc2)c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1081649 | 6270 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 453 | 4 | 1 | 3 | 4.8 | COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@H](C)C3)cc2)c1 | 10.1016/j.bmcl.2010.01.043 | |||
46880812 | 6023 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 430 | 3 | 1 | 4 | 4.3 | C[C@H]1CN(C(=O)c2ccc(-c3cncs3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1080320 | 6023 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 430 | 3 | 1 | 4 | 4.3 | C[C@H]1CN(C(=O)c2ccc(-c3cncs3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1 | 10.1016/j.bmcl.2010.01.043 | |||
46880497 | 6373 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 423 | 3 | 1 | 2 | 4.8 | O=C(c1ccc(-c2ccccc2)cc1)N1CCCN(C(=O)c2ccc3cc[nH]c3c2)CC1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1082164 | 6373 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 423 | 3 | 1 | 2 | 4.8 | O=C(c1ccc(-c2ccccc2)cc1)N1CCCN(C(=O)c2ccc3cc[nH]c3c2)CC1 | 10.1016/j.bmcl.2010.01.043 | |||
44409770 | 141455 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 461 | 6 | 3 | 7 | 4.0 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CC4C=CC3C4)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL383766 | 141455 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 461 | 6 | 3 | 7 | 4.0 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CC4C=CC3C4)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
122178604 | 121404 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 571 | 11 | 3 | 7 | 5.3 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581037 | 121404 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 571 | 11 | 3 | 7 | 5.3 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
46880496 | 6372 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 453 | 4 | 1 | 3 | 4.8 | COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@H]3C)cc2)c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1082163 | 6372 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 453 | 4 | 1 | 3 | 4.8 | COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@H]3C)cc2)c1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL502208 | 216638 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O | 10.1074/jbc.m609796200 | |||||
145980382 | 166738 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 601 | 5 | 1 | 4 | 7.4 | Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
CHEMBL4281310 | 166738 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 601 | 5 | 1 | 4 | 7.4 | Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1 | 10.1021/acs.jmedchem.8b00794 | |||
44389186 | 64636 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 379 | 7 | 1 | 5 | 4.8 | CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
CHEMBL181739 | 64636 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 379 | 7 | 1 | 5 | 4.8 | CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1 | 10.1016/j.bmcl.2004.11.075 | |||
44409864 | 75526 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 502 | 9 | 3 | 8 | 4.0 | CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL204266 | 75526 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 502 | 9 | 3 | 8 | 4.0 | CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
44409975 | 75817 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 411 | 7 | 3 | 7 | 3.3 | CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL204835 | 75817 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 411 | 7 | 3 | 7 | 3.3 | CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
44409455 | 75995 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 487 | 6 | 3 | 7 | 4.1 | CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1 | 10.1021/jm0510934 | |||
CHEMBL205286 | 75995 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 487 | 6 | 3 | 7 | 4.1 | CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1 | 10.1021/jm0510934 | |||
11441554 | 220 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 420 | 6 | 4 | 6 | 3.9 | O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N | 10.1021/jm060461g | |||
5871 | 220 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 420 | 6 | 4 | 6 | 3.9 | O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N | 10.1021/jm060461g | |||
CHEMBL212761 | 220 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 420 | 6 | 4 | 6 | 3.9 | O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N | 10.1021/jm060461g | |||
11340329 | 79633 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 468 | 9 | 4 | 6 | 4.4 | Nc1nc(N)c(-c2ccc(NC(=O)NCCc3ccccc3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm060461g | |||
CHEMBL211454 | 79633 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 468 | 9 | 4 | 6 | 4.4 | Nc1nc(N)c(-c2ccc(NC(=O)NCCc3ccccc3)cc2)c(COCc2ccccc2)n1 | 10.1021/jm060461g | |||
122178605 | 121405 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 574 | 11 | 2 | 6 | 5.8 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581038 | 121405 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 574 | 11 | 2 | 6 | 5.8 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
127047655 | 139701 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 571 | 11 | 3 | 7 | 5.2 | COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3797531 | 139701 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 571 | 11 | 3 | 7 | 5.2 | COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
46880672 | 6198 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 453 | 4 | 1 | 3 | 4.8 | COc1ccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)cc1 | 10.1016/j.bmcl.2010.01.043 | |||
CHEMBL1081254 | 6198 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 453 | 4 | 1 | 3 | 4.8 | COc1ccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)cc1 | 10.1016/j.bmcl.2010.01.043 | |||
66601728 | 81872 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 514 | 5 | 2 | 4 | 4.3 | CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
CHEMBL2164499 | 81872 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 514 | 5 | 2 | 4 | 4.3 | CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1 | 10.1016/j.bmc.2012.07.018 | |||
70689440 | 73218 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 554 | 8 | 2 | 5 | 5.0 | Cc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1 | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011818 | 73218 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 554 | 8 | 2 | 5 | 5.0 | Cc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1 | 10.1016/j.bmcl.2012.01.014 | |||
70693644 | 73252 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 496 | 9 | 1 | 3 | 6.7 | CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCc2ccc(Oc3ccc(F)cc3F)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011893 | 73252 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 496 | 9 | 1 | 3 | 6.7 | CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCc2ccc(Oc3ccc(F)cc3F)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
70695747 | 73216 | None | 0 | Mouse | Functional | pIC50 | = | 8.2 | 8.2 | 1 | 2 | ChEMBL | 540 | 8 | 2 | 5 | 4.7 | CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
CHEMBL2011816 | 73216 | None | 0 | Mouse | Functional | pIC50 | = | 8.2 | 8.2 | 1 | 2 | ChEMBL | 540 | 8 | 2 | 5 | 4.7 | CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O | 10.1016/j.bmcl.2012.01.014 | |||
11225576 | 166132 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 489 | 9 | 3 | 8 | 4.0 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
CHEMBL425594 | 166132 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 489 | 9 | 3 | 8 | 4.0 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2006.01.012 | |||
11225576 | 166132 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 489 | 9 | 3 | 8 | 4.0 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1 | 10.1021/jm0510934 | |||
CHEMBL425594 | 166132 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 489 | 9 | 3 | 8 | 4.0 | CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1 | 10.1021/jm0510934 | |||
122178608 | 121409 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 570 | 11 | 2 | 6 | 6.0 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581041 | 121409 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 570 | 11 | 2 | 6 | 6.0 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
122178609 | 121410 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 586 | 12 | 2 | 7 | 5.7 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
CHEMBL3581042 | 121410 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 586 | 12 | 2 | 7 | 5.7 | COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1 | 10.1016/j.bmcl.2014.11.031 | |||
56942388 | 140030 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 613 | 12 | 3 | 7 | 5.3 | COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3799687 | 140030 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 613 | 12 | 3 | 7 | 5.3 | COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
56942535 | 139848 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 593 | 12 | 4 | 7 | 4.4 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
CHEMBL3798525 | 139848 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 593 | 12 | 4 | 7 | 4.4 | COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1 | 10.1016/j.bmcl.2016.04.003 | |||
11176805 | 77363 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 391 | 7 | 3 | 6 | 4.5 | CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1 | 10.1021/jm0510934 | |||
CHEMBL208374 | 77363 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 391 | 7 | 3 | 6 | 4.5 | CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1 | 10.1021/jm0510934 | |||
71453405 | 81942 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 |