GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	44570962	183275	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	435	4	1	5	2.5	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL480821	183275	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	435	4	1	5	2.5	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	145950336	162277	0	None	-	1	Human	10.0	pEC50	=	10	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	3	3	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172656	162277	0	None	-	1	Human	10.0	pEC50	=	10	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	3	3	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	156016416	177083	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	6	3	5	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641513	177083	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	6	3	5	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	16752684	94063	1	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251572	94063	1	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	156014430	176649	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635542	176649	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	156016416	177083	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	6	3	5	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641513	177083	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	6	3	5	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	16752684	94063	1	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2008.12.042
	CHEMBL251572	94063	1	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2008.12.042
	44570963	183298	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	435	4	1	5	2.5	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL481013	183298	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	435	4	1	5	2.5	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	156014430	176649	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635542	176649	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	44444563	154416	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	478	5	1	6	3.7	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)cc1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL401134	154416	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	478	5	1	6	3.7	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)cc1)CC2	10.1016/j.bmcl.2007.09.067
	156011926	176826	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	6	4	5	2.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4638297	176826	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	6	4	5	2.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	44571002	190504	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H](O)[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL518774	190504	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H](O)[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	44449987	95449	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	493	16	4	10	0.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCSCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL259166	95449	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	493	16	4	10	0.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCSCCO	10.1016/j.bmcl.2008.03.059
	25010378	158851	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	525	16	4	11	-0.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(=O)(=O)CCO	10.1016/j.bmcl.2008.03.059
	CHEMBL410074	158851	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	525	16	4	11	-0.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(=O)(=O)CCO	10.1016/j.bmcl.2008.03.059
	44449955	158865	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	509	14	4	9	1.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(O)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL410085	158865	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	509	14	4	9	1.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(O)c1	10.1016/j.bmcl.2008.03.059
	156011926	176826	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	6	4	5	2.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4638297	176826	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	6	4	5	2.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	156017918	177232	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	591	7	3	7	2.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4643530	177232	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	591	7	3	7	2.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1	10.1021/acs.jmedchem.0c00828
	156015100	176998	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640507	176998	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	156017918	177232	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	591	7	3	7	2.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4643530	177232	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	591	7	3	7	2.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1	10.1021/acs.jmedchem.0c00828
	44570960	183406	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	417	4	1	5	2.4	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL481796	183406	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	417	4	1	5	2.4	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	24894012	176223	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	497	14	4	9	1.6	CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.05.100
	CHEMBL460680	176223	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	497	14	4	9	1.6	CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.05.100
	156015100	176998	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640507	176998	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	44437979	10229	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	655	12	5	5	4.1	NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1	10.1016/j.bmc.2007.01.057
	CHEMBL1162065	10229	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	655	12	5	5	4.1	NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1	10.1016/j.bmc.2007.01.057
	44437979	10229	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	655	12	5	5	4.1	NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1	10.1016/j.bmc.2007.01.057
	CHEMBL1162065	10229	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	655	12	5	5	4.1	NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1	10.1016/j.bmc.2007.01.057
	44454303	97120	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	CHEMBL270666	97120	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	156020725	177531	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647963	177531	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	44570764	183467	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	481	4	1	4	3.8	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(Cl)ccc3Cl)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL482220	183467	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	481	4	1	4	3.8	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(Cl)ccc3Cl)cc2)C1	10.1016/j.bmcl.2008.12.042
	24803512	88579	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364468	88579	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1Cl	10.6019/CHEMBL2364335
	156020725	177531	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647963	177531	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	9917957	109230	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Compound was evaluated for GH release for effect on human GH secretagogue receptorCompound was evaluated for GH release for effect on human GH secretagogue receptor	ChEMBL	683	14	4	5	4.3	NC(=O)CN(CCc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1021/jm970342o
	CHEMBL322912	109230	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Compound was evaluated for GH release for effect on human GH secretagogue receptorCompound was evaluated for GH release for effect on human GH secretagogue receptor	ChEMBL	683	14	4	5	4.3	NC(=O)CN(CCc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1021/jm970342o
	44447855	193187	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	539	15	4	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL539929	193187	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	539	15	4	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	178024	1940	30	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	5867	1940	30	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	CHEMBL13817	1940	30	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	156013414	176898	4	None	1905	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639111	176898	4	None	1905	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	156013297	176910	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639229	176910	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	44452749	95768	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	499	7	2	6	4.5	COc1ccc(F)c(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.1016/j.bmcl.2007.12.021
	CHEMBL260819	95768	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	499	7	2	6	4.5	COc1ccc(F)c(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.1016/j.bmcl.2007.12.021
	44570765	190844	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	421	4	1	5	2.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL519301	190844	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	421	4	1	5	2.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	59007047	88537	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1C	10.6019/CHEMBL2364335
	CHEMBL2364427	88537	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1C	10.6019/CHEMBL2364335
	178024	1940	30	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	5867	1940	30	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	CHEMBL13817	1940	30	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	25022640	97352	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	CHEMBL271876	97352	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	44454337	155063	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL404545	155063	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	44447839	94550	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	499	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254765	94550	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	499	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	156013414	176898	4	None	1905	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639111	176898	4	None	1905	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	156013297	176910	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639229	176910	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	44447857	166323	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	497	14	4	10	0.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1Cl)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL428592	166323	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	497	14	4	10	0.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1Cl)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	156019724	177417	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4646219	177417	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	22888474	63134	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	CHEMBL179823	63134	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	11306502	63311	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180094	63311	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	11306502	63311	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180094	63311	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	11306502	63311	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180094	63311	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	22888476	122303	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	CHEMBL360547	122303	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	22888476	122303	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	CHEMBL360547	122303	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	44454117	155016	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL404336	155016	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	44444559	94000	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	451	4	1	5	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251169	94000	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	451	4	1	5	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2	10.1016/j.bmcl.2007.09.067
	156011750	176716	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636502	176716	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156019724	177417	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4646219	177417	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	44453123	97537	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	503	6	2	5	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(Cl)ccc2F)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL272753	97537	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	503	6	2	5	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(Cl)ccc2F)cc1	10.1016/j.bmcl.2007.12.021
	44570966	182987	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL480037	182987	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	59007062	88539	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364429	88539	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1F	10.6019/CHEMBL2364335
	24803514	88584	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364472	88584	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1Cl	10.6019/CHEMBL2364335
	44447852	155022	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	477	14	4	10	0.6	Cc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL404354	155022	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	477	14	4	10	0.6	Cc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	156011750	176716	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636502	176716	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	44450016	160013	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	489	17	4	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL411259	160013	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	489	17	4	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCCO	10.1016/j.bmcl.2008.03.059
	44454367	94817	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	CHEMBL256235	94817	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	22867441	10218	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161835	10218	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1016/j.bmc.2007.01.057
	16114096	78750	1	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1	10.1021/jm0704550
	CHEMBL2113324	78750	1	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1	10.1021/jm0704550
	22867441	10218	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161835	10218	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44447841	154539	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.6	CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1Cl)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL401827	154539	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.6	CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1Cl)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	69195371	88463	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364354	88463	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	44450101	158913	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	495	13	4	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCc1cccc(O)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL410135	158913	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	495	13	4	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCc1cccc(O)c1	10.1016/j.bmcl.2008.03.059
	44391039	131266	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	540	9	1	7	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc([N+](=O)[O-])c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL369329	131266	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	540	9	1	7	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc([N+](=O)[O-])c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44449988	160554	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	477	16	4	10	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCOCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL411697	160554	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	477	16	4	10	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCOCCO	10.1016/j.bmcl.2008.03.059
	44447843	94578	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1C(F)(F)F)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254973	94578	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1C(F)(F)F)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	10280020	62762	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	529	8	1	5	6.2	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(Cl)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL178900	62762	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	529	8	1	5	6.2	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(Cl)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	156021297	177515	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647797	177515	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44444571	93545	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	498	5	1	7	4.1	COc1cc2c(cc1N1C[C@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL248544	93545	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	498	5	1	7	4.1	COc1cc2c(cc1N1C[C@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	10553921	104081	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	517	9	4	4	2.9	CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	CHEMBL310457	104081	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	517	9	4	4	2.9	CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	10345516	138745	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1016/j.bmc.2007.01.057
	CHEMBL379074	138745	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1016/j.bmc.2007.01.057
	156012122	176807	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637980	176807	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156021297	177515	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647797	177515	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11584048	97579	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1Cl	10.1016/j.bmcl.2007.12.021
	CHEMBL272993	97579	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1Cl	10.1016/j.bmcl.2007.12.021
	24755624	156758	1	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL407706	156758	1	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1	10.1016/j.bmcl.2007.12.021
	24755624	156758	1	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1	10.1016/j.bmcl.2008.12.042
	CHEMBL407706	156758	1	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1	10.1016/j.bmcl.2008.12.042
	69197353	88517	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364408	88517	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	44454060	154793	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL403180	154793	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	10553921	104081	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	517	9	4	4	2.9	CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	CHEMBL310457	104081	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	517	9	4	4	2.9	CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	10345516	138745	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1016/j.bmc.2007.01.057
	CHEMBL379074	138745	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1016/j.bmc.2007.01.057
	127047525	139237	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	858	20	7	9	5.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798559	139237	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	858	20	7	9	5.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	156022162	177632	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	8	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649634	177632	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	8	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	156012122	176807	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637980	176807	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	20600693	63126	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	566	11	1	6	4.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL179785	63126	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	566	11	1	6	4.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44560945	178523	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	391	9	2	7	2.1	CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.05.100
	CHEMBL471751	178523	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	391	9	2	7	2.1	CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.05.100
	216208	9635	27	None	-5	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	CHEMBL113313	9635	27	None	-5	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	44449891	96027	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	539	16	4	10	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL262358	96027	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	539	16	4	10	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	216208	9635	27	None	-5	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	CHEMBL113313	9635	27	None	-5	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	156021478	177481	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	7	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647258	177481	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	7	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1	10.1021/acs.jmedchem.0c00828
	44437955	10227	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	534	11	4	6	2.6	NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21	10.1016/j.bmc.2007.01.057
	CHEMBL1162063	10227	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	534	11	4	6	2.6	NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21	10.1016/j.bmc.2007.01.057
	9807597	182435	3	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	513	7	4	4	3.5	CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	CHEMBL47938	182435	3	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	513	7	4	4	3.5	CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	156018364	177339	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645148	177339	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156021478	177481	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	7	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647258	177481	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	7	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1	10.1021/acs.jmedchem.0c00828
	156022090	177629	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649603	177629	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156022162	177632	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	8	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649634	177632	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	8	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	56926175	68671	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923504	68671	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	56926356	68677	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923512	68677	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	nan
	56926461	68694	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923609	68694	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926462	68695	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923610	68695	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	57399248	68702	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923617	68702	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	11664206	68711	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923626	68711	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	56926894	68722	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1923638	68722	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	11526745	68726	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923642	68726	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	11526696	71258	13	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1923502	71258	13	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1963249	71258	13	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	134130631	141841	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	576	5	4	6	3.4	COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1	nan
	CHEMBL3889512	141841	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	576	5	4	6	3.4	COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1	nan
	134137202	142294	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	552	5	3	6	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3893048	142294	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	552	5	3	6	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134137257	142605	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	540	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3895776	142605	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	540	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134133518	142921	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	552	2	4	5	3.4	CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	CHEMBL3898348	142921	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	552	2	4	5	3.4	CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	134133352	142973	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3898794	142973	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O	nan
	134134286	143162	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	598	5	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3900284	143162	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	598	5	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134135712	143606	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	533	4	4	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O	nan
	CHEMBL3903845	143606	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	533	4	4	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O	nan
	11512561	143836	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3905791	143836	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134133037	144034	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3907497	144034	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134132893	144330	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	4	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3909834	144330	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	4	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134132152	144399	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3910300	144399	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O	nan
	134142218	144754	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	564	4	4	5	3.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3913052	144754	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	564	4	4	5	3.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134142433	144793	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	3	4	6	1.8	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3913335	144793	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	3	4	6	1.8	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O	nan
	134142839	144853	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3913855	144853	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134143635	145041	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3915269	145041	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O	nan
	134143366	145227	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	578	4	4	4	4.6	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3916659	145227	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	578	4	4	4	4.6	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134142204	145404	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3918046	145404	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	11584702	145658	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	540	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3920049	145658	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	540	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134140270	145840	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	536	4	3	5	3.1	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3921499	145840	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	536	4	3	5	3.1	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134139279	145914	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	594	4	4	5	4.1	CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3922056	145914	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	594	4	4	5	4.1	CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134139286	146021	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3922810	146021	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134141886	146585	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	546	4	4	5	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3927481	146585	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	546	4	4	5	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	117812380	147219	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3932408	147219	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134138595	147222	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	544	2	4	5	3.3	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1	nan
	CHEMBL3932434	147222	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	544	2	4	5	3.3	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1	nan
	134138824	147482	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	525	3	3	6	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3934402	147482	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	525	3	3	6	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134148504	147822	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.4	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3937200	147822	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.4	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134149306	147942	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	3	3	5	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3938104	147942	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	3	3	5	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134145791	148254	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	596	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3940705	148254	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	596	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134145564	148558	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3943086	148558	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134147441	148957	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	2	4	5	3.0	C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	CHEMBL3946348	148957	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	2	4	5	3.0	C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	134155239	150482	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	564	3	4	5	3.4	O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1	nan
	CHEMBL3958460	150482	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	564	3	4	5	3.4	O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1	nan
	134155132	150560	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	502	4	3	5	2.9	CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3959108	150560	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	502	4	3	5	2.9	CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154079	151871	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	512	4	4	5	3.2	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3970499	151871	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	512	4	4	5	3.2	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O	nan
	134153247	152188	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	582	4	4	6	2.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3973085	152188	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	582	4	4	6	2.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	44570763	189665	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	449	4	1	4	2.7	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(F)ccc3F)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL517543	189665	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	449	4	1	4	2.7	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(F)ccc3F)cc2)C1	10.1016/j.bmcl.2008.12.042
	9890504	89310	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	461	10	3	10	-0.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)N1CC[C@@H](O)C1	10.1021/jm7010595
	CHEMBL237699	89310	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	461	10	3	10	-0.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)N1CC[C@@H](O)C1	10.1021/jm7010595
	24969109	88447	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	2	6	3.8	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cccc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364338	88447	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	2	6	3.8	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cccc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1	10.6019/CHEMBL2364335
	11518200	88462	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364353	88462	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11641108	88491	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364382	88491	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197887	88512	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364403	88512	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	44447856	161265	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	558	15	4	12	1.6	Cc1noc(C)c1-c1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL414394	161265	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	558	15	4	12	1.6	Cc1noc(C)c1-c1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	156018364	177339	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645148	177339	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156022090	177629	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649603	177629	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	10323604	10212	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161828	10212	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	10323604	10212	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161828	10212	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44447853	94523	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	493	15	4	11	0.3	COc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254565	94523	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	493	15	4	11	0.3	COc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	25022503	155023	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	540	15	4	11	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1cccnc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL404355	155023	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	540	15	4	11	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1cccnc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44269035	27125	0	None	-	1	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	490	5	4	5	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL13675	27125	0	None	-	1	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	490	5	4	5	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	44269039	97889	0	None	-	1	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@@]2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL275093	97889	0	None	-	1	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@@]2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	145956061	162143	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170481	162143	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	44570965	189245	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	418	4	2	6	0.8	Cc1ccc(-c2ccc(S(=O)(=O)N3CCNC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL516602	189245	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	418	4	2	6	0.8	Cc1ccc(-c2ccc(S(=O)(=O)N3CCNC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	69194933	88534	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	5	2	5	5.0	Cc1csc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3C)cc2)c1	10.6019/CHEMBL2364335
	CHEMBL2364424	88534	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	5	2	5	5.0	Cc1csc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3C)cc2)c1	10.6019/CHEMBL2364335
	69198297	88543	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364432	88543	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	44447850	94494	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	488	14	4	11	0.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1C#N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254363	94494	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	488	14	4	11	0.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1C#N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44450015	95871	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	475	16	4	9	0.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL261358	95871	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	475	16	4	9	0.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCO	10.1016/j.bmcl.2008.03.059
	178024	1940	30	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	5867	1940	30	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	CHEMBL13817	1940	30	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	178024	1940	30	None	1	3	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(97)10199-8
	5867	1940	30	None	1	3	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(97)10199-8
	CHEMBL13817	1940	30	None	1	3	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(97)10199-8
	178024	1940	30	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	5867	1940	30	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	CHEMBL13817	1940	30	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	145956061	162143	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170481	162143	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	44450104	95357	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	496	14	4	10	-1.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(N)(=O)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL258761	95357	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	496	14	4	10	-1.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(N)(=O)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL500468	212344	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2008.03.059
	CHEMBL500468	212344	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm300414b
	22888475	63494	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	523	9	1	6	5.4	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C=O)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180246	63494	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	523	9	1	6	5.4	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C=O)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL500468	212344	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2005.02.040
	162653916	179963	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	707	15	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753794	179963	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	707	15	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL500468	212344	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2008.02.021
	CHEMBL500468	212344	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2008.05.100
	178024	1940	30	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	5867	1940	30	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	CHEMBL13817	1940	30	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	156012849	176724	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636571	176724	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44390996	63973	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	563	8	1	5	6.6	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(C(F)(F)F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181063	63973	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	563	8	1	5	6.6	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(C(F)(F)F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	11353414	64285	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	553	11	1	7	4.5	COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181764	64285	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	553	11	1	7	4.5	COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	11353414	64285	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	553	11	1	7	4.5	COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181764	64285	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	553	11	1	7	4.5	COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44347919	16197	0	None	-	1	Rat	8.8	pEC50	=	8.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	606	14	3	6	4.2	C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL122939	16197	0	None	-	1	Rat	8.8	pEC50	=	8.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	606	14	3	6	4.2	C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	16133832	211583	15	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/acs.jmedchem.8b01644
	CHEMBL425281	211583	15	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/acs.jmedchem.8b01644
	145957574	161751	0	None	57	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164328	161751	0	None	57	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	9875705	203590	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	CHEMBL79263	203590	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	156012849	176724	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636571	176724	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156013219	176915	0	None	60	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639379	176915	0	None	60	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11648350	88490	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364381	88490	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	59007043	88493	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(Cl)cccc2c1	10.6019/CHEMBL2364335
	CHEMBL2364384	88493	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(Cl)cccc2c1	10.6019/CHEMBL2364335
	69197106	88536	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)s3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364426	88536	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)s3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	24803348	88541	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	6	2	6	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364430	88541	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	6	2	6	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1F	10.6019/CHEMBL2364335
	69197228	88587	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	5	4.6	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364475	88587	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	5	4.6	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	16114291	190700	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/acs.jmedchem.1c02191
	CHEMBL5190973	190700	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/acs.jmedchem.1c02191
	16114292	96486	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm701292s
	CHEMBL266063	96486	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm701292s
	9875705	203590	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	CHEMBL79263	203590	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	44436850	91118	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	564	11	4	6	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL240509	91118	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	564	11	4	6	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44447840	94551	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	497	14	4	10	0.9	CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254766	94551	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	497	14	4	10	0.9	CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44447854	94524	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	469	14	4	10	0.7	CC(C)(N)C(=O)N[C@H](COCC1CCCCC1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254566	94524	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	469	14	4	10	0.7	CC(C)(N)C(=O)N[C@H](COCC1CCCCC1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL105462	206726	34	None	12	2	Rat	8.8	pEC50	=	8.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm980197u
	44447844	94436	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.3	CC(C)(N)C(=O)N[C@H](COCc1cccc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL253965	94436	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.3	CC(C)(N)C(=O)N[C@H](COCc1cccc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44450017	95899	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	461	15	4	9	0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL261544	95899	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	461	15	4	9	0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	10118326	23889	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	509	9	4	4	3.7	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL133848	23889	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	509	9	4	4	3.7	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1	10.1016/j.bmc.2007.01.057
	10458218	27280	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL13687	27280	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	10745618	112488	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	568	13	2	4	4.5	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CC1	10.1021/jm980197u
	CHEMBL331093	112488	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	568	13	2	4	4.5	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CC1	10.1021/jm980197u
	10118326	23889	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	509	9	4	4	3.7	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL133848	23889	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	509	9	4	4	3.7	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1	10.1016/j.bmc.2007.01.057
	156010457	176480	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4632657	176480	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1	10.1021/acs.jmedchem.0c00828
	23649669	153433	7	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL398372	153433	7	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	23649669	153433	7	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1021/jm7010595
	CHEMBL398372	153433	7	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1021/jm7010595
	23649669	153433	7	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.05.100
	CHEMBL398372	153433	7	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.05.100
	23649669	153433	7	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL398372	153433	7	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44437955	10227	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	534	11	4	6	2.6	NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21	10.1016/j.bmc.2007.01.057
	CHEMBL1162063	10227	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	534	11	4	6	2.6	NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21	10.1016/j.bmc.2007.01.057
	10626337	100755	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL295984	100755	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1016/j.bmc.2007.01.057
	156010457	176480	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4632657	176480	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1	10.1021/acs.jmedchem.0c00828
	156012445	176761	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637284	176761	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156015928	177007	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640615	177007	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44452750	95810	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	481	7	2	6	4.4	COc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.1016/j.bmcl.2007.12.021
	CHEMBL261030	95810	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	481	7	2	6	4.4	COc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.1016/j.bmcl.2007.12.021
	44452932	97138	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1F	10.1016/j.bmcl.2007.12.021
	CHEMBL270790	97138	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1F	10.1016/j.bmcl.2007.12.021
	44570700	183377	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	486	6	2	6	2.1	COc1cccc(C(=O)Nc2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2)c1	10.1016/j.bmcl.2008.12.042
	CHEMBL481620	183377	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	486	6	2	6	2.1	COc1cccc(C(=O)Nc2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2)c1	10.1016/j.bmcl.2008.12.042
	69197169	88508	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364399	88508	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11641478	88516	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)s1	10.6019/CHEMBL2364335
	CHEMBL2364407	88516	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)s1	10.6019/CHEMBL2364335
	24803350	88552	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1C	10.6019/CHEMBL2364335
	CHEMBL2364441	88552	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1C	10.6019/CHEMBL2364335
	11547664	88592	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)c(F)c1	10.6019/CHEMBL2364335
	CHEMBL2364480	88592	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)c(F)c1	10.6019/CHEMBL2364335
	44579802	186186	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL488965	186186	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44444572	93585	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	498	5	1	7	4.1	COc1cc2c(cc1N1C[C@@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL248745	93585	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	498	5	1	7	4.1	COc1cc2c(cc1N1C[C@@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	145962494	161525	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160705	161525	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145951150	162226	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4171914	162226	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	44434120	89477	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	523	15	3	9	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL237926	89477	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	523	15	3	9	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1	10.1016/j.bmcl.2007.07.099
	9827234	5264	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	498	9	5	4	3.1	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1c[nH]c2ccccc12)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL106841	5264	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	498	9	5	4	3.1	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1c[nH]c2ccccc12)C1CCNCC1	10.1016/j.bmc.2007.01.057
	44411718	10209	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	467	7	2	5	3.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161825	10209	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	467	7	2	5	3.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	44437953	10226	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	522	9	3	6	1.5	NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21	10.1016/j.bmc.2007.01.057
	CHEMBL1162062	10226	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	522	9	3	6	1.5	NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21	10.1016/j.bmc.2007.01.057
	44293557	100619	0	None	1	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL294923	100619	0	None	1	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL540001	100619	0	None	1	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	127046473	139250	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	661	17	6	8	4.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798645	139250	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	661	17	6	8	4.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	156012203	176760	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	558	7	3	8	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637255	176760	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	558	7	3	8	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1	10.1021/acs.jmedchem.0c00828
	156016696	177056	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641201	177056	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11525404	94937	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL256808	94937	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	44571004	183464	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	431	5	1	5	2.6	CNC1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccc(C)o3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL482203	183464	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	431	5	1	5	2.6	CNC1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccc(C)o3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL105462	206726	34	None	12	2	Rat	8.0	pEC50	=	8	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/s0960-894x(97)10199-8
	24969294	88452	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	460	5	3	6	3.1	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)c[nH]c3=O)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364343	88452	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	460	5	3	6	3.1	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)c[nH]c3=O)cc2F)o1	10.6019/CHEMBL2364335
	69194607	88467	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	466	6	2	6	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364358	88467	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	466	6	2	6	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1	10.6019/CHEMBL2364335
	69197049	88468	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)s1	10.6019/CHEMBL2364335
	CHEMBL2364359	88468	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)s1	10.6019/CHEMBL2364335
	69195141	88486	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	431	5	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1csc2ccccc12	10.6019/CHEMBL2364335
	CHEMBL2364377	88486	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	431	5	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1csc2ccccc12	10.6019/CHEMBL2364335
	11682686	88499	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	395	4	2	4	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc4ccccc34)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364390	88499	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	395	4	2	4	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc4ccccc34)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69198021	88542	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccc(Cl)c12	10.6019/CHEMBL2364335
	CHEMBL2364431	88542	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccc(Cl)c12	10.6019/CHEMBL2364335
	11655608	88555	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)c(F)c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364444	88555	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)c(F)c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69194649	88589	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	5	5.2	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364477	88589	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	5	5.2	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69196750	88591	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)nc1	10.6019/CHEMBL2364335
	CHEMBL2364479	88591	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)nc1	10.6019/CHEMBL2364335
	23730339	147587	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	475	10	3	10	0.4	CC1(O)CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1	10.1021/jm7010595
	CHEMBL393531	147587	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	475	10	3	10	0.4	CC1(O)CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1	10.1021/jm7010595
	156016696	177056	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641201	177056	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145993528	166764	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	561	5	1	4	6.6	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4294083	166764	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	561	5	1	4	6.6	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	156012203	176760	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	558	7	3	8	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637255	176760	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	558	7	3	8	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1	10.1021/acs.jmedchem.0c00828
	145950201	162392	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174476	162392	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	44281466	168816	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	436	8	2	4	2.9	Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL442151	168816	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	436	8	2	4	2.9	Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	44452806	96235	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	486	7	2	7	4.6	CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL263916	96235	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	486	7	2	7	4.6	CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	44452885	97365	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	481	8	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL271948	97365	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	481	8	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	11633712	158788	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	446	5	2	6	3.9	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL410013	158788	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	446	5	2	6	3.9	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	57390496	68713	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	CHEMBL1923628	68713	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	56926782	68715	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923631	68715	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926785	68718	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923634	68718	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926892	68720	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923636	68720	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926893	68721	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	nan
	CHEMBL1923637	68721	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	nan
	134131183	141936	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3890296	141936	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134133488	142704	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	600	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3896536	142704	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	600	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134134870	143859	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	3	4	5	2.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3905987	143859	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	3	4	5	2.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134132958	144128	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	536	3	3	5	2.4	C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C	nan
	CHEMBL3908264	144128	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	536	3	3	5	2.4	C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C	nan
	134132265	144438	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	3	4	6	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O	nan
	CHEMBL3910661	144438	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	3	4	6	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O	nan
	76460236	144927	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	4	3.0	CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3914338	144927	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	4	3.0	CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134141159	146196	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3924192	146196	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134149092	147921	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	4	5	2.5	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	CHEMBL3937924	147921	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	4	5	2.5	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	134146570	148248	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3940653	148248	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134145820	148502	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3942642	148502	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134155024	150480	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	3	4	3.6	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3958451	150480	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	3	4	3.6	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134155282	150810	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3961108	150810	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134152627	151016	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3963078	151016	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134150696	151547	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	3.2	CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3967506	151547	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	3.2	CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134150029	151583	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.3	CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3967783	151583	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.3	CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134153608	151838	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	3.2	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3970180	151838	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	3.2	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154022	152293	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	532	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3973940	152293	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	532	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134151899	152785	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3978207	152785	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	134156625	153117	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	5	1.7	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3981072	153117	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	5	1.7	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	16040587	178804	0	None	-14	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human Ghrelin receptorAgonist activity at human Ghrelin receptor	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm801332q
	CHEMBL473921	178804	0	None	-14	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human Ghrelin receptorAgonist activity at human Ghrelin receptor	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm801332q
	44576247	212451	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.1c02191
	CHEMBL506986	212451	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.1c02191
	44576247	212451	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayInverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1016/j.bmcl.2016.04.003
	CHEMBL506986	212451	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayInverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1016/j.bmcl.2016.04.003
	CHEMBL3578015	210019	0	None	-33	2	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	CHEMBL3578018	210022	0	None	-15	2	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	69198097	88473	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	452	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364364	88473	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	452	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)cc1	10.6019/CHEMBL2364335
	69198438	88475	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)s1	10.6019/CHEMBL2364335
	CHEMBL2364366	88475	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)s1	10.6019/CHEMBL2364335
	69196473	88484	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	452	5	2	6	4.3	C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)ccc2C#N)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364375	88484	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	452	5	2	6	4.3	C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)ccc2C#N)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69197657	88485	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	497	8	2	7	4.5	COc1ccc(Oc2cccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)c2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364376	88485	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	497	8	2	7	4.5	COc1ccc(Oc2cccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)c2)cc1	10.6019/CHEMBL2364335
	69195983	88506	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	5	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364397	88506	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	5	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196844	88523	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364414	88523	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11647817	88527	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	437	4	2	4	3.7	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1	10.6019/CHEMBL2364335
	CHEMBL2364418	88527	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	437	4	2	4	3.7	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1	10.6019/CHEMBL2364335
	69196864	88545	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(F)cc2F)cc1	10.6019/CHEMBL2364335
	CHEMBL2364434	88545	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(F)cc2F)cc1	10.6019/CHEMBL2364335
	69198407	88574	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	5	2	5	3.6	COc1cc(Br)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	CHEMBL2364463	88574	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	5	2	5	3.6	COc1cc(Br)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	44579958	190748	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	381	7	2	4	3.2	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL519171	190748	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	381	7	2	4	3.2	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	156020713	177514	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	477	6	3	7	0.7	Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647751	177514	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	477	6	3	7	0.7	Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1	10.1021/acs.jmedchem.0c00828
	134139753	145503	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	5	3	5	2.5	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3918783	145503	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	5	3	5	2.5	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	44449923	95891	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	601	17	4	11	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(S(=O)(=O)CCO)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL261497	95891	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	601	17	4	11	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(S(=O)(=O)CCO)c1	10.1016/j.bmcl.2008.03.059
	156020713	177514	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	477	6	3	7	0.7	Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647751	177514	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	477	6	3	7	0.7	Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1	10.1021/acs.jmedchem.0c00828
	44434110	88084	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	515	13	3	9	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL235135	88084	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	515	13	3	9	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL3578018	210022	0	None	-15	2	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	44450102	95327	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	511	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL258550	95327	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	511	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCO	10.1016/j.bmcl.2008.03.059
	16114290	136684	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	534	11	3	5	5.3	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL374992	136684	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	534	11	3	5	5.3	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	11664206	68711	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923626	68711	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	71453489	207623	13	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Val mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Val mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	207623	13	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Val mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Val mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	9870965	63983	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	509	9	1	5	5.3	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181092	63983	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	509	9	1	5	5.3	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44434051	88985	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237058	88985	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	44434053	146325	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1cccc(NS(C)(=O)=O)c1	10.1016/j.bmcl.2007.07.099
	CHEMBL392522	146325	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1cccc(NS(C)(=O)=O)c1	10.1016/j.bmcl.2007.07.099
	145988557	166707	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	523	4	1	2	6.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4292914	166707	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	523	4	1	2	6.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL2170775	207618	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44434083	89600	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL238155	89600	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1	10.1016/j.bmcl.2007.07.099
	44436884	91121	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	565	11	5	7	3.1	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL240522	91121	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	565	11	5	7	3.1	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	16114098	141079	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	534	11	3	5	5.4	Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL385131	141079	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	534	11	3	5	5.4	Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	16113246	94239	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252643	94239	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	22888486	63987	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	552	9	2	6	5.5	CC(=O)Nc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	CHEMBL181108	63987	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	552	9	2	6	5.5	CC(=O)Nc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	71453489	207623	13	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.9b02122
	CHEMBL2170781	207623	13	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.9b02122
	156018539	177235	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4643595	177235	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	145949755	162384	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174302	162384	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	156013970	176666	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	624	7	3	6	3.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635743	176666	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	624	7	3	6	3.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1	10.1021/acs.jmedchem.0c00828
	156018539	177235	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4643595	177235	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	69197178	88445	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(Cl)s2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364336	88445	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(Cl)s2)cc1	10.6019/CHEMBL2364335
	69194396	88496	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	7	2	6	4.8	CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364387	88496	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	7	2	6	4.8	CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	69195258	88528	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	447	6	2	7	4.0	COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364419	88528	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	447	6	2	7	4.0	COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11604627	88544	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364433	88544	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197381	88562	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	486	6	2	7	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2cccc(C)n2)s1	10.6019/CHEMBL2364335
	CHEMBL2364451	88562	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	486	6	2	7	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2cccc(C)n2)s1	10.6019/CHEMBL2364335
	11576185	88569	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2nccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364458	88569	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2nccs2)cc1	10.6019/CHEMBL2364335
	11633856	88595	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ncccn2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364483	88595	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ncccn2)cc1	10.6019/CHEMBL2364335
	59007104	88598	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	1	6	4.8	COc1ccc(N2C[C@H](C)N(C)[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364486	88598	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	1	6	4.8	COc1ccc(N2C[C@H](C)N(C)[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2170779	207621	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44579824	183528	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL482623	183528	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1	10.1016/j.bmcl.2008.07.120
	44579883	186255	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL489403	186255	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1	10.1016/j.bmcl.2008.07.120
	44579861	192918	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1	10.1016/j.bmcl.2008.07.120
	CHEMBL528332	192918	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1	10.1016/j.bmcl.2008.07.120
	44579906	192019	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL521612	192019	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	145992125	166197	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	552	5	2	5	6.2	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4283504	166197	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	552	5	2	5	6.2	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	156016682	177192	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4642860	177192	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL2170776	207619	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(C(C)(C)C)cc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	16752689	187784	0	None	-5	3	Rabbit	6.9	pEC50	=	6.9	Functional	Activity at ghrelin receptor in New Zealand White rabbit gastric antral smooth muscle by calcium mobilization-based FLIPR assayActivity at ghrelin receptor in New Zealand White rabbit gastric antral smooth muscle by calcium mobilization-based FLIPR assay	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.071
	CHEMBL501315	187784	0	None	-5	3	Rabbit	6.9	pEC50	=	6.9	Functional	Activity at ghrelin receptor in New Zealand White rabbit gastric antral smooth muscle by calcium mobilization-based FLIPR assayActivity at ghrelin receptor in New Zealand White rabbit gastric antral smooth muscle by calcium mobilization-based FLIPR assay	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.071
	44444557	154148	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	493	4	0	5	3.7	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1cccc(Br)c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL399704	154148	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	493	4	0	5	3.7	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1cccc(Br)c1)CC2	10.1016/j.bmcl.2007.09.067
	145957404	161500	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4160261	161500	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21	10.1021/acs.jmedchem.8b00322
	145955250	161974	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	4	4	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167776	161974	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	4	4	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1	10.1021/acs.jmedchem.8b00322
	145950261	162179	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171137	162179	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	156014569	176658	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	599	7	2	7	2.5	CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635694	176658	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	599	7	2	7	2.5	CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	44452776	95881	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	5	2	5	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL261466	95881	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	5	2	5	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1	10.1016/j.bmcl.2007.12.021
	69196695	88458	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	7	2	6	4.5	COc1ccc(NS(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364349	88458	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	7	2	6	4.5	COc1ccc(NS(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	59007058	88466	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	6	3.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)s1	10.6019/CHEMBL2364335
	CHEMBL2364357	88466	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	6	3.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)s1	10.6019/CHEMBL2364335
	156016682	177192	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4642860	177192	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44579842	184168	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	CHEMBL485091	184168	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	145986461	166660	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4291926	166660	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	145950261	162179	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171137	162179	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	10602593	112344	0	None	-	1	Rat	7.9	pEC50	=	7.9	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	542	12	2	4	4.1	CCNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL330860	112344	0	None	-	1	Rat	7.9	pEC50	=	7.9	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	542	12	2	4	4.1	CCNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44391038	64254	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	555	13	1	4	5.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181627	64254	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	555	13	1	4	5.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL2170783	207625	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@@H](N)CCCCN)C(c1ccccc1)c1ccccc1)C(N)=O	10.1021/jm300414b
	CHEMBL2170779	207621	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	156013970	176666	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	624	7	3	6	3.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635743	176666	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	624	7	3	6	3.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1	10.1021/acs.jmedchem.0c00828
	156014569	176658	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	599	7	2	7	2.5	CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635694	176658	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	599	7	2	7	2.5	CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	56926173	68670	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923501	68670	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	134138625	147498	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	494	3	3	5	1.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3934561	147498	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	494	3	3	5	1.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	155526063	170469	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1174	34	16	14	-2.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4456830	170469	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1174	34	16	14	-2.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	145957404	161500	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4160261	161500	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21	10.1021/acs.jmedchem.8b00322
	145955250	161974	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	4	4	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167776	161974	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	4	4	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1	10.1021/acs.jmedchem.8b00322
	44454060	154793	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL403180	154793	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	57399248	68702	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at ghrelin receptor by cell based assayAgonist activity at ghrelin receptor by cell based assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	CHEMBL1923617	68702	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at ghrelin receptor by cell based assayAgonist activity at ghrelin receptor by cell based assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	145949755	162384	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174302	162384	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	44434109	145748	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	529	13	2	9	1.8	CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL392076	145748	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	529	13	2	9	1.8	CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	9890375	97818	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL274599	97818	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL558802	97818	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	44436876	146486	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	580	11	4	7	4.6	COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL392663	146486	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	580	11	4	7	4.6	COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	9890375	97818	0	None	-1	3	Rat	7.9	pEC50	=	7.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	CHEMBL274599	97818	0	None	-1	3	Rat	7.9	pEC50	=	7.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	CHEMBL558802	97818	0	None	-1	3	Rat	7.9	pEC50	=	7.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	9890375	97818	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL274599	97818	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL558802	97818	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	44281466	168816	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	436	8	2	4	2.9	Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL442151	168816	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	436	8	2	4	2.9	Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	162672839	182440	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	681	14	3	7	5.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4793824	182440	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	681	14	3	7	5.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	22888428	64019	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	508	9	2	4	4.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)NC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181247	64019	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	508	9	2	4	4.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)NC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	23730227	147341	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	477	15	4	10	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCCO	10.1021/jm7010595
	CHEMBL393330	147341	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	477	15	4	10	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCCO	10.1021/jm7010595
	44450133	159846	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	481	13	3	10	-0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCS(C)(=O)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL411122	159846	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	481	13	3	10	-0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCS(C)(=O)=O	10.1016/j.bmcl.2008.03.059
	44579821	183646	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	CHEMBL483455	183646	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	44579879	186412	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL490627	186412	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1	10.1016/j.bmcl.2008.07.120
	44450071	96137	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	489	15	3	10	0.6	CCOC(=O)CCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	CHEMBL263141	96137	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	489	15	3	10	0.6	CCOC(=O)CCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	16113906	136699	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	612	12	5	5	6.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	CHEMBL375102	136699	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	612	12	5	5	6.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	44579752	186377	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	377	8	1	4	3.7	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL490390	186377	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	377	8	1	4	3.7	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1	10.1016/j.bmcl.2008.07.120
	44436887	90528	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	563	11	5	6	3.7	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL239464	90528	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	563	11	5	6	3.7	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44434076	89347	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	513	10	2	9	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21	10.1016/j.bmcl.2007.07.099
	CHEMBL237717	89347	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	513	10	2	9	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21	10.1016/j.bmcl.2007.07.099
	145952740	161951	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4167481	161951	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	23648250	78753	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	585	10	4	5	6.0	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL2113327	78753	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	585	10	4	5	6.0	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	16113577	84512	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	573	12	4	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	CHEMBL223725	84512	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	573	12	4	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	162657465	180459	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	652	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4759418	180459	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	652	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1	10.1021/acs.jmedchem.9b02122
	44444574	93586	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1CCNC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL248746	93586	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1CCNC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	145952740	161951	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4167481	161951	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	11532288	96472	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	7	2.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-n2cccn2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL265950	96472	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	7	2.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-n2cccn2)cc1	10.1016/j.bmcl.2007.12.021
	11576186	154686	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	7	3.8	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccn3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.1016/j.bmcl.2007.12.021
	CHEMBL402632	154686	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	7	3.8	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccn3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.1016/j.bmcl.2007.12.021
	44570964	183299	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	407	4	1	5	1.7	Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL481014	183299	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	407	4	1	5	1.7	Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	44570921	183373	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL481601	183373	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	59007073	88446	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)nc1	10.6019/CHEMBL2364335
	CHEMBL2364337	88446	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)nc1	10.6019/CHEMBL2364335
	69197749	88455	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364346	88455	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11682796	88457	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	401	6	2	5	3.3	COc1ccc(NS(=O)(=O)/C=C/c2ccccc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364348	88457	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	401	6	2	5	3.3	COc1ccc(NS(=O)(=O)/C=C/c2ccccc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69198460	88469	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.6019/CHEMBL2364335
	CHEMBL2364360	88469	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.6019/CHEMBL2364335
	69198360	88477	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	466	6	2	6	4.1	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364368	88477	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	466	6	2	6	4.1	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11683967	88489	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cccs2)c1	10.6019/CHEMBL2364335
	CHEMBL2364380	88489	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cccs2)c1	10.6019/CHEMBL2364335
	69195261	88497	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	7	2	6	5.2	CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364388	88497	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	7	2	6	5.2	CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	11516766	88501	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	395	4	2	4	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364392	88501	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	395	4	2	4	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11525161	88558	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	447	5	2	5	4.2	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)c(F)c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364447	88558	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	447	5	2	5	4.2	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)c(F)c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69194533	88588	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(F)c(-c2ccco2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364476	88588	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(F)c(-c2ccco2)cc1F	10.6019/CHEMBL2364335
	69197165	88600	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	427	5	3	6	3.6	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364488	88600	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	427	5	3	6	3.6	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	44579777	186401	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL490601	186401	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44454432	154719	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL402808	154719	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	44434112	168294	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL438154	168294	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44579908	186291	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	C[C@@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL489610	186291	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	C[C@@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	145954311	161936	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167267	161936	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	44434124	88230	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC#N)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL235817	88230	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC#N)n1	10.1016/j.bmcl.2007.07.099
	162659161	180809	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	642	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4763471	180809	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	642	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44444556	93966	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	471	6	0	5	4.4	CCOc1ccc(CC(=O)N2CCc3cc(OC)c(N4C[C@H](C)N(C)[C@H](C)C4)cc32)cc1Cl	10.1016/j.bmcl.2007.09.067
	CHEMBL250973	93966	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	471	6	0	5	4.4	CCOc1ccc(CC(=O)N2CCc3cc(OC)c(N4C[C@H](C)N(C)[C@H](C)C4)cc32)cc1Cl	10.1016/j.bmcl.2007.09.067
	145950963	162256	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172411	162256	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145952396	162453	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	CHEMBL4175534	162453	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	156011695	176781	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	8	2	7	2.2	O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637585	176781	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	8	2	7	2.2	O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	44452887	159031	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	451	6	2	5	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2007.12.021
	CHEMBL410282	159031	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	451	6	2	5	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2007.12.021
	46882522	5636	0	None	-39	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	440	7	2	5	3.6	CC(C)Oc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078208	5636	0	None	-39	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	440	7	2	5	3.6	CC(C)Oc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	69195349	88480	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	5	2	5	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Br)c1	10.6019/CHEMBL2364335
	CHEMBL2364371	88480	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	5	2	5	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Br)c1	10.6019/CHEMBL2364335
	69198352	88601	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	6	2	6	4.0	COc1ccc(N2CCN[C@@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364489	88601	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	6	2	6	4.0	COc1ccc(N2CCN[C@@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	44446188	154852	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL403542	154852	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	145954311	161936	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167267	161936	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	46882521	5635	0	None	-158	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	458	6	2	4	4.5	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078207	5635	0	None	-158	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	458	6	2	4	4.5	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.09.027
	44445620	154140	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	11	2	6	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL399651	154140	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	11	2	6	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	22862453	98007	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	490	5	4	5	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(O)c1ccccc1O2	10.1016/s0960-894x(97)10199-8
	CHEMBL275795	98007	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	490	5	4	5	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(O)c1ccccc1O2	10.1016/s0960-894x(97)10199-8
	10675061	96096	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	598	13	2	5	4.3	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1	10.1021/jm980197u
	CHEMBL262889	96096	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	598	13	2	5	4.3	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1	10.1021/jm980197u
	10026738	162219	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL417182	162219	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL557206	162219	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	56926464	68697	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	nan
	CHEMBL1923612	68697	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	nan
	155540883	172388	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.36 +/- 0.01 nM)Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.36 +/- 0.01 nM)	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172388	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.36 +/- 0.01 nM)Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.36 +/- 0.01 nM)	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	10210658	10228	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	593	13	5	5	3.6	NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL1162064	10228	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	593	13	5	5	3.6	NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1016/j.bmc.2007.01.057
	145952396	162453	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	CHEMBL4175534	162453	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	CHEMBL2170784	207626	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	134139080	147150	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	CHEMBL3931856	147150	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	156011695	176781	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	8	2	7	2.2	O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637585	176781	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	8	2	7	2.2	O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL2170697	207612	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44434080	89481	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	44434080	89481	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL237933	89481	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL237933	89481	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2008.01.100
	10210658	10228	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	593	13	5	5	3.6	NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL1162064	10228	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	593	13	5	5	3.6	NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1016/j.bmc.2007.01.057
	10026738	162219	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL417182	162219	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL557206	162219	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	10530983	167821	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	564	11	2	4	4.0	CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL434609	167821	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	564	11	2	4	4.0	CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44391003	122805	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	531	10	1	4	5.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1F)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL361612	122805	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	531	10	1	4	5.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1F)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL2170780	207622	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	145950963	162256	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172411	162256	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	127047409	139101	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	888	24	8	10	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797639	139101	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	888	24	8	10	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	10745533	139590	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL380096	139590	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	44437971	200833	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	7	2	4	3.9	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL611489	200833	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	7	2	4	3.9	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	16113693	137489	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	589	12	4	6	5.6	COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL376471	137489	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	589	12	4	6	5.6	COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	11692516	68706	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	554	3	3	5	3.1	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923621	68706	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	554	3	3	5	3.1	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	155557019	174015	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.34 +/- 0.12 nM)Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.34 +/- 0.12 nM)	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174015	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.34 +/- 0.12 nM)Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.34 +/- 0.12 nM)	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	9810101	98792	12	None	-5	2	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL281764	98792	12	None	-5	2	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	10745533	139590	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL380096	139590	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	44437971	200833	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	7	2	4	3.9	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL611489	200833	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	7	2	4	3.9	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44579909	186320	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL489819	186320	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	44436882	145483	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	10	4	6	4.2	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1	10.1021/jm0704550
	CHEMBL391859	145483	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	10	4	6	4.2	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1	10.1021/jm0704550
	CHEMBL2170698	207613	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44434122	89081	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCCC#N)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237302	89081	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCCC#N)n1	10.1016/j.bmcl.2007.07.099
	145992142	166218	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	475	4	2	3	5.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4283858	166218	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	475	4	2	3	5.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL3578006	210013	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)O	10.1021/jm501702q
	145953016	162037	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4168863	162037	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	44454304	97154	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	CHEMBL270876	97154	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	44454092	97200	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL271082	97200	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	44454338	97386	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL272085	97386	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	22867310	29827	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	4	4	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2O	10.1016/s0960-894x(97)10199-8
	CHEMBL13891	29827	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	4	4	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2O	10.1016/s0960-894x(97)10199-8
	162653802	179949	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	656	15	4	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753592	179949	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	656	15	4	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44436886	161406	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	595	12	5	8	3.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL415674	161406	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	595	12	5	8	3.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	9987037	11927	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1183385	11927	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL294324	11927	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	44391008	64536	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	481	9	1	5	4.6	CCN(CC)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL182137	64536	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	481	9	1	5	4.6	CCN(CC)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	22888379	167750	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	584	12	2	5	4.8	CC(=O)NC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	CHEMBL434152	167750	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	584	12	2	5	4.8	CC(=O)NC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	44444564	94036	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	478	5	1	6	3.7	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1cccc(-c3ccccn3)c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251366	94036	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	478	5	1	6	3.7	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1cccc(-c3ccccn3)c1)CC2	10.1016/j.bmcl.2007.09.067
	145961213	161614	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	3	4	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4162174	161614	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	3	4	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	145953016	162037	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4168863	162037	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	145949595	162174	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171040	162174	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145974293	162474	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175823	162474	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44452929	97094	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccco2)c1	10.1016/j.bmcl.2007.12.021
	CHEMBL270573	97094	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccco2)c1	10.1016/j.bmcl.2007.12.021
	46882396	5767	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc(C)[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079187	5767	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc(C)[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	44570698	183376	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	456	5	2	5	2.0	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL481619	183376	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	456	5	2	5	2.0	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	24969292	88449	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	2	6	3.8	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccn3)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364340	88449	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	2	6	3.8	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccn3)cc2F)o1	10.6019/CHEMBL2364335
	69194665	88482	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	476	6	2	7	3.9	COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.6019/CHEMBL2364335
	CHEMBL2364373	88482	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	476	6	2	7	3.9	COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.6019/CHEMBL2364335
	11524465	88502	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	413	4	2	4	4.0	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc(Cl)c3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364393	88502	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	413	4	2	4	4.0	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc(Cl)c3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11576404	88513	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	469	6	2	5	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364404	88513	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	469	6	2	5	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69194865	88532	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	409	4	2	4	4.1	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2ccccc12	10.6019/CHEMBL2364335
	CHEMBL2364422	88532	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	409	4	2	4	4.1	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2ccccc12	10.6019/CHEMBL2364335
	11712498	88546	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	469	6	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2F)cc1	10.6019/CHEMBL2364335
	CHEMBL2364435	88546	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	469	6	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2F)cc1	10.6019/CHEMBL2364335
	69195296	88551	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3F)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364440	88551	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3F)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11518242	88554	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.9	Cc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	CHEMBL2364443	88554	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.9	Cc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	69197366	88559	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364448	88559	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11503413	88576	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	454	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccn2C)cc1	10.6019/CHEMBL2364335
	CHEMBL2364465	88576	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	454	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccn2C)cc1	10.6019/CHEMBL2364335
	11647900	88582	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1cc(-c2ccco2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	CHEMBL2364470	88582	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1cc(-c2ccco2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	11669734	88583	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	CHEMBL2364471	88583	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	44391007	64535	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	480	9	1	4	4.1	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL182136	64535	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	480	9	1	4	4.1	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	145994050	166791	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	6	7.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4294493	166791	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	6	7.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	156016392	177072	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641386	177072	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL3578006	210013	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)O	10.1021/jm501702q
	25098836	190862	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL519322	190862	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	145957574	161751	0	None	57	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164328	161751	0	None	57	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	44411745	10211	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161827	10211	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	10626337	100755	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL295984	100755	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1016/j.bmc.2007.01.057
	156013219	176915	0	None	60	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639379	176915	0	None	60	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	22888352	63606	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	537	11	1	6	4.9	CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180659	63606	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	537	11	1	6	4.9	CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	22888352	63606	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	537	11	1	6	4.9	CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180659	63606	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	537	11	1	6	4.9	CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	10649999	16925	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	534	11	2	5	3.8	CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL125498	16925	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	534	11	2	5	3.8	CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	156015928	177007	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640615	177007	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156012445	176761	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637284	176761	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44411634	10208	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161824	10208	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44411634	10208	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161824	10208	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44390986	64338	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1ccccc1CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181832	64338	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1ccccc1CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL2170695	207610	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	156011766	176734	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	569	6	2	7	2.2	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636780	176734	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	569	6	2	7	2.2	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	44281449	112895	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	559	12	4	7	1.4	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL33182	112895	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	559	12	4	7	1.4	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1	10.1016/j.bmc.2007.01.057
	44281449	112895	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	559	12	4	7	1.4	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL33182	112895	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	559	12	4	7	1.4	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1	10.1016/j.bmc.2007.01.057
	23648249	78752	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	557	9	4	5	5.4	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1	10.1021/jm0704550
	CHEMBL2113326	78752	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	557	9	4	5	5.4	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1	10.1021/jm0704550
	10166594	64305	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	563	8	1	5	6.6	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C(F)(F)F)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181786	64305	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	563	8	1	5	6.6	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C(F)(F)F)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44391010	64543	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	9	1	6	6.3	CSc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	CHEMBL182158	64543	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	9	1	6	6.3	CSc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	23648244	91582	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL241775	91582	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	155557019	174015	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.40 +/- 0.05 nM)Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.40 +/- 0.05 nM)	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174015	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.40 +/- 0.05 nM)Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.40 +/- 0.05 nM)	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	44444565	94064	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	474	5	1	8	3.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccon3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251573	94064	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	474	5	1	8	3.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccon3)s1)CC2	10.1016/j.bmcl.2007.09.067
	145957075	161729	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164040	161729	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44411745	10211	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161827	10211	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	156013684	176691	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636178	176691	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156011766	176734	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	569	6	2	7	2.2	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636780	176734	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	569	6	2	7	2.2	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	11539642	97479	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	448	6	2	8	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL272540	97479	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	448	6	2	8	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)s1	10.1016/j.bmcl.2007.12.021
	44570702	183254	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	463	4	1	5	3.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL480639	183254	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	463	4	1	5	3.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	11683968	88488	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364379	88488	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197883	88511	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2F)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364402	88511	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2F)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69195597	88524	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2Cl)s1	10.6019/CHEMBL2364335
	CHEMBL2364415	88524	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2Cl)s1	10.6019/CHEMBL2364335
	59007081	88538	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	5	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(Cl)c2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364428	88538	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	5	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(Cl)c2)cc1	10.6019/CHEMBL2364335
	11648834	88593	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364481	88593	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1F	10.6019/CHEMBL2364335
	44411753	10213	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161829	10213	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	44411753	10213	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161829	10213	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	10415000	167504	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	11	3	6	2.7	CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL432461	167504	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	11	3	6	2.7	CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	71453489	207623	13	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Phe119:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Phe119:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	207623	13	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Phe119:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Phe119:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	156013684	176691	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636178	176691	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	10415000	167504	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	11	3	6	2.7	CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL432461	167504	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	11	3	6	2.7	CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	156019457	177368	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645625	177368	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44449922	95774	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	615	17	3	11	1.0	CN(CCc1cccc(S(=O)(=O)CCO)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	CHEMBL260849	95774	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	615	17	3	11	1.0	CN(CCc1cccc(S(=O)(=O)CCO)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	44269019	97774	0	None	-	1	Rat	8.5	pEC50	=	8.5	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	3	4	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL274340	97774	0	None	-	1	Rat	8.5	pEC50	=	8.5	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	3	4	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	44579840	184166	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL485090	184166	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44579907	186465	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL491044	186465	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	44579805	186483	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL491221	186483	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44434113	88221	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL235793	88221	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	127048060	139331	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	789	20	6	10	5.4	COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799222	139331	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	789	20	6	10	5.4	COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	57399248	68702	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923617	68702	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	44268965	23858	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	4	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2=O)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL13383	23858	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	4	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2=O)C1	10.1016/s0960-894x(97)10199-8
	10675800	113295	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	654	11	2	4	4.3	CNC(=O)[C@@H](Cc1ccc(I)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL332414	113295	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	654	11	2	4	4.3	CNC(=O)[C@@H](Cc1ccc(I)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44391002	123392	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	507	10	1	4	5.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL362798	123392	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	507	10	1	4	5.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44579857	186341	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL490009	186341	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1	10.1016/j.bmcl.2008.07.120
	44434018	88064	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	399	8	3	8	0.9	COC(=O)CCn1nnnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL235012	88064	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	399	8	3	8	0.9	COC(=O)CCn1nnnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	44579641	186314	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	370	7	1	4	4.0	CSc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL489794	186314	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	370	7	1	4	4.0	CSc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	44579996	186553	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	367	7	2	4	2.8	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)COc2ccccc2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL491835	186553	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	367	7	2	4	2.8	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)COc2ccccc2)cc1	10.1016/j.bmcl.2008.07.120
	44579919	190755	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	444	9	1	4	5.3	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(-c2ccccc2)c1OC	10.1016/j.bmcl.2008.07.120
	CHEMBL519196	190755	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	444	9	1	4	5.3	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(-c2ccccc2)c1OC	10.1016/j.bmcl.2008.07.120
	44454092	97200	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL271082	97200	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	44450070	158105	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	461	14	4	9	0.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(=O)O	10.1016/j.bmcl.2008.03.059
	CHEMBL409258	158105	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	461	14	4	9	0.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(=O)O	10.1016/j.bmcl.2008.03.059
	156016392	177072	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641386	177072	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145961213	161614	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	3	4	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4162174	161614	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	3	4	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	145949595	162174	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171040	162174	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145974293	162474	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175823	162474	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44390905	64126	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	544	10	1	6	3.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181337	64126	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	544	10	1	6	3.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44391040	64130	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	577	10	1	6	5.0	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181352	64130	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	577	10	1	6	5.0	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	10579444	113744	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	598	13	2	5	4.3	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1cccc2ccccc12)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1	10.1021/jm980197u
	CHEMBL332987	113744	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	598	13	2	5	4.3	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1cccc2ccccc12)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1	10.1021/jm980197u
	162645413	179146	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	677	14	3	7	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4744051	179146	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	677	14	3	7	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44293091	187603	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL49884	187603	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	16114011	137610	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	563	10	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1	10.1021/jm070024h
	CHEMBL376736	137610	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	563	10	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1	10.1021/jm070024h
	145981343	166156	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	669	6	1	6	7.6	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4282719	166156	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	669	6	1	6	7.6	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44391048	62619	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	467	8	2	5	4.2	CC(C)NCCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL178502	62619	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	467	8	2	5	4.2	CC(C)NCCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	44454399	154600	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL402086	154600	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1	10.1016/j.bmcl.2008.01.100
	44293091	187603	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL49884	187603	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	155540883	172388	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172388	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	44579801	186578	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL492028	186578	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	168276220	189827	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	261	6	1	1	4.2	CCCCCCCc1cc(=O)c2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	CHEMBL5177954	189827	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	261	6	1	1	4.2	CCCCCCCc1cc(=O)c2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	145958774	161716	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163811	161716	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145950877	162445	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175360	162445	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44450135	158157	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2008.03.059
	CHEMBL409327	158157	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2008.03.059
	44454302	158833	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	CHEMBL410060	158833	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	16203237	96503	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	496	10	3	6	4.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1	10.1021/jm070024h
	CHEMBL266199	96503	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	496	10	3	6	4.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1	10.1021/jm070024h
	56926462	68695	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923610	68695	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	162660604	180637	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	700	15	3	9	5.0	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4761319	180637	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	700	15	3	9	5.0	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	145956753	161608	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4162000	161608	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	71453489	207623	13	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	207623	13	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44446190	94120	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL251855	94120	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	44446189	154835	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL403426	154835	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	10744738	16028	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1cccc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL122420	16028	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1cccc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL2170699	207614	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44454432	154719	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL402808	154719	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	44454397	154984	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC(C#N)Cc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL404227	154984	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC(C#N)Cc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	145949381	162165	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170865	162165	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	22862431	30270	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	3	4	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc3O2)CC1	10.1016/s0960-894x(97)10199-8
	CHEMBL13930	30270	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	3	4	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc3O2)CC1	10.1016/s0960-894x(97)10199-8
	162653781	179900	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	732	15	4	8	6.2	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753046	179900	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	732	15	4	8	6.2	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	156013764	176697	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	7	1	7	3.0	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636229	176697	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	7	1	7	3.0	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	145958317	161763	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164531	161763	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145949381	162165	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170865	162165	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	145950877	162445	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175360	162445	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	156013764	176697	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	7	1	7	3.0	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636229	176697	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	7	1	7	3.0	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156020452	177460	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	4	5	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4646979	177460	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	4	5	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	24969201	88453	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	476	6	2	7	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364344	88453	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	476	6	2	7	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1Cl	10.6019/CHEMBL2364335
	69197403	88478	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	5	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc2cc(Cl)ccc2s1	10.6019/CHEMBL2364335
	CHEMBL2364369	88478	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	5	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc2cc(Cl)ccc2s1	10.6019/CHEMBL2364335
	59007071	88492	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	3	7	3.5	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364383	88492	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	3	7	3.5	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11547135	88505	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	461	5	2	5	5.1	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccc(Cl)s4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364396	88505	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	461	5	2	5	5.1	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccc(Cl)s4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11567764	88509	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	411	5	2	6	2.9	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-n4cccn4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364400	88509	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	411	5	2	6	2.9	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-n4cccn4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11511157	88519	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2C)s1	10.6019/CHEMBL2364335
	CHEMBL2364410	88519	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2C)s1	10.6019/CHEMBL2364335
	11547599	88521	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(NS(=O)(=O)c2ccc(-c3c(C)cccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364412	88521	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(NS(=O)(=O)c2ccc(-c3c(C)cccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197133	88531	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)s1	10.6019/CHEMBL2364335
	CHEMBL2364421	88531	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)s1	10.6019/CHEMBL2364335
	69197849	88556	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	429	5	2	5	4.1	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364445	88556	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	429	5	2	5	4.1	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69198350	88563	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	9	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csnn2)s1	10.6019/CHEMBL2364335
	CHEMBL2364452	88563	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	9	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csnn2)s1	10.6019/CHEMBL2364335
	156020452	177460	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	4	5	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4646979	177460	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	4	5	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	44579860	188314	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL507551	188314	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	145956415	161514	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160541	161514	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145956415	161514	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160541	161514	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145956753	161608	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4162000	161608	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145958774	161716	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163811	161716	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145955718	161985	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167965	161985	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145952404	162186	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171300	162186	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL3578014	210018	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	44436816	91373	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	12	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL241242	91373	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	12	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44391028	63967	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	451	9	1	4	3.9	CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181051	63967	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	451	9	1	4	3.9	CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44390906	131581	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	467	7	2	5	4.2	CC(C)(CN)CNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL369571	131581	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	467	7	2	5	4.2	CC(C)(CN)CNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	44434052	88986	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccc(NS(C)(=O)=O)cc1	10.1016/j.bmcl.2007.07.099
	CHEMBL237059	88986	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccc(NS(C)(=O)=O)cc1	10.1016/j.bmcl.2007.07.099
	44450169	159203	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	471	12	3	8	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCC(F)(F)F	10.1016/j.bmcl.2008.03.059
	CHEMBL410499	159203	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	471	12	3	8	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCC(F)(F)F	10.1016/j.bmcl.2008.03.059
	56926894	68722	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923638	68722	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	44391027	128281	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	12	1	4	5.6	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL366916	128281	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	12	1	4	5.6	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	44579803	186187	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL488966	186187	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	145952404	162186	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171300	162186	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL3578014	210018	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	11526696	71258	13	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm1012374
	CHEMBL1923502	71258	13	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm1012374
	CHEMBL1963249	71258	13	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm1012374
	44450045	158690	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	447	14	4	9	0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL409894	158690	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	447	14	4	9	0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCO	10.1016/j.bmcl.2008.03.059
	44434012	88645	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	13	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL236513	88645	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	13	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	44454398	97149	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL270851	97149	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1	10.1016/j.bmcl.2008.01.100
	11526745	68726	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923642	68726	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	44391020	63533	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	543	11	1	5	5.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180337	63533	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	543	11	1	5	5.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	162643920	181198	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	679	14	4	8	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4777792	181198	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	679	14	4	8	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	155540883	172388	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.41 +/- 0.13 nM)Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.41 +/- 0.13 nM)	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172388	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.41 +/- 0.13 nM)Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.41 +/- 0.13 nM)	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	145955718	161985	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167965	161985	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	23648236	78742	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	13	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1	10.1021/jm0704550
	CHEMBL2113317	78742	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	13	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1	10.1021/jm0704550
	145958317	161763	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164531	161763	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	162649014	179361	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	702	14	4	7	6.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4746362	179361	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	702	14	4	7	6.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1	10.1021/acs.jmedchem.9b02122
	44434123	145017	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL391510	145017	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N	10.1016/j.bmcl.2007.07.099
	11526696	71258	13	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923502	71258	13	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1963249	71258	13	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	122178179	120750	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1002	29	10	9	3.8	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578008	120750	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1002	29	10	9	3.8	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	145980382	166090	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4281310	166090	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	71453489	207623	13	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	207623	13	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	134149793	148073	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	5	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O	nan
	CHEMBL3939196	148073	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	5	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O	nan
	145980333	166028	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	577	6	1	4	7.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4280040	166028	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	577	6	1	4	7.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44579823	183499	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL482420	183499	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	145957075	161729	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164040	161729	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	145951150	162226	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4171914	162226	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	44449864	158284	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	539	16	4	10	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCCCO)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL409462	158284	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	539	16	4	10	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCCCO)c1	10.1016/j.bmcl.2008.03.059
	10005618	10225	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	11	1	3	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1	10.1016/j.bmc.2007.01.057
	CHEMBL1162058	10225	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	11	1	3	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1	10.1016/j.bmc.2007.01.057
	15481181	77391	2	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL209020	77391	2	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	9810101	98792	12	None	5	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL281764	98792	12	None	5	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	15481188	140679	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1016/j.bmc.2007.01.057
	CHEMBL382844	140679	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1016/j.bmc.2007.01.057
	CHEMBL130229	206945	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL		None	None	None		CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1016/j.bmc.2007.01.057
	16114292	96486	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL266063	96486	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	16114292	96486	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL266063	96486	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	23730225	153642	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	435	12	4	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCO	10.1021/jm7010595
	CHEMBL398570	153642	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	435	12	4	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCO	10.1021/jm7010595
	10530781	15402	0	None	-	1	Rat	8.5	pEC50	=	8.5	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	554	12	2	4	4.2	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL122108	15402	0	None	-	1	Rat	8.5	pEC50	=	8.5	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	554	12	2	4	4.2	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	10005618	10225	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	11	1	3	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1	10.1016/j.bmc.2007.01.057
	CHEMBL1162058	10225	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	11	1	3	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1	10.1016/j.bmc.2007.01.057
	15481181	77391	2	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL209020	77391	2	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	9810101	98792	12	None	5	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL281764	98792	12	None	5	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	15481188	140679	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1016/j.bmc.2007.01.057
	CHEMBL382844	140679	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1016/j.bmc.2007.01.057
	CHEMBL130229	206945	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL		None	None	None		CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1016/j.bmc.2007.01.057
	156011385	176804	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	518	8	3	5	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637916	176804	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	518	8	3	5	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44449956	96167	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	523	14	3	9	2.0	CN(CCc1cccc(O)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	CHEMBL263389	96167	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	523	14	3	9	2.0	CN(CCc1cccc(O)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	44447846	94458	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	547	15	4	11	1.2	CC(C)(N)C(=O)N[C@H](COCc1cccc(OC(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254166	94458	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	547	15	4	11	1.2	CC(C)(N)C(=O)N[C@H](COCc1cccc(OC(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44444566	154229	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	470	5	1	7	3.4	COc1cc2c(cc1N1CCN[C@@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL400124	154229	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	470	5	1	7	3.4	COc1cc2c(cc1N1CCN[C@@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	156011385	176804	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	518	8	3	5	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637916	176804	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	518	8	3	5	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156019457	177368	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645625	177368	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44570961	191962	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	421	4	1	5	2.2	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)c(F)c2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL521246	191962	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	421	4	1	5	2.2	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)c(F)c2)C1	10.1016/j.bmcl.2008.12.042
	69195095	88535	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)c(F)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364425	88535	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)c(F)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69194503	88571	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364460	88571	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1Cl	10.6019/CHEMBL2364335
	59007103	88597	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	456	6	2	7	3.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cn1	10.6019/CHEMBL2364335
	CHEMBL2364485	88597	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	456	6	2	7	3.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cn1	10.6019/CHEMBL2364335
	69197358	88603	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	3	6	4.1	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364491	88603	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	3	6	4.1	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2F)o1	10.6019/CHEMBL2364335
	44450046	95412	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	501	14	4	9	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCN1CCNC1=O	10.1016/j.bmcl.2008.03.059
	CHEMBL259016	95412	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	501	14	4	9	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCN1CCNC1=O	10.1016/j.bmcl.2008.03.059
	23730341	89312	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	502	11	3	10	0.1	CC(=O)N[C@@H]1CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1	10.1021/jm7010595
	CHEMBL237701	89312	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	502	11	3	10	0.1	CC(=O)N[C@@H]1CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1	10.1021/jm7010595
	71453489	207623	13	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Asp mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Asp mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	207623	13	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Asp mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Asp mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44390914	63307	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	11	1	5	4.9	CCCOC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180093	63307	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	11	1	5	4.9	CCCOC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	22888424	122482	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	11	1	4	5.7	CC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	CHEMBL360877	122482	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	11	1	4	5.7	CC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	71453489	207623	13	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	207623	13	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	162671996	182249	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	707	16	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4791255	182249	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	707	16	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	23730228	89162	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	477	14	3	10	0.6	CN(CCCCO)C(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1021/jm7010595
	CHEMBL237492	89162	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	477	14	3	10	0.6	CN(CCCCO)C(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1021/jm7010595
	71453489	207623	13	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	207623	13	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44444568	93544	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	470	5	1	7	3.4	COc1cc2c(cc1N1CCN[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL248542	93544	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	470	5	1	7	3.4	COc1cc2c(cc1N1CCN[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	15481185	76908	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL207970	76908	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	156011736	176849	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	605	7	3	7	3.0	Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4638566	176849	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	605	7	3	7	3.0	Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	25022506	94823	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL256263	94823	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.1016/j.bmcl.2007.12.021
	24803347	154489	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL401548	154489	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1	10.1016/j.bmcl.2007.12.021
	46882394	5765	0	None	1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079185	5765	0	None	1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	46882395	5766	0	None	-1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2[nH]cnc2C)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079186	5766	0	None	-1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2[nH]cnc2C)CC3)cc1	10.1016/j.bmcl.2009.09.027
	44570699	190711	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	474	5	2	5	2.2	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3F)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL519121	190711	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	474	5	2	5	2.2	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3F)cc2)C1	10.1016/j.bmcl.2008.12.042
	69196498	88483	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)s1	10.6019/CHEMBL2364335
	CHEMBL2364374	88483	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)s1	10.6019/CHEMBL2364335
	69197028	88522	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)c3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364413	88522	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)c3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69198238	88533	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	5	2	5	4.7	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364423	88533	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	5	2	5	4.7	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	11712867	88570	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364459	88570	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)cc1F	10.6019/CHEMBL2364335
	69194471	88585	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(F)c1	10.6019/CHEMBL2364335
	CHEMBL2364473	88585	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(F)c1	10.6019/CHEMBL2364335
	11698505	88594	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364482	88594	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1	10.6019/CHEMBL2364335
	9950632	88278	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.05.100
	CHEMBL236038	88278	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.05.100
	44579880	186253	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL489401	186253	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	44579841	191955	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL521176	191955	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44434010	88345	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	CHEMBL236311	88345	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	9950632	88278	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2007.07.099
	9950632	88278	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL236038	88278	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL236038	88278	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.01.100
	44434010	88345	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL236311	88345	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	44437966	200408	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	607	8	1	5	4.8	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL608827	200408	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	607	8	1	5	4.8	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44437969	200832	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	565	8	1	4	5.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL611488	200832	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	565	8	1	4	5.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44437966	200408	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	607	8	1	5	4.8	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL608827	200408	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	607	8	1	5	4.8	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44437969	200832	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	565	8	1	4	5.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL611488	200832	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	565	8	1	4	5.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44454368	94818	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCC(C#N)c2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL256236	94818	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCC(C#N)c2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	145987684	166724	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	4	7.8	CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4293331	166724	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	4	7.8	CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44444560	154415	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	541	5	1	5	3.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)Cc1cccc(I)c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL401133	154415	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	541	5	1	5	3.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)Cc1cccc(I)c1)CC2	10.1016/j.bmcl.2007.09.067
	145953855	161965	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167669	161965	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44570923	183374	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	403	4	1	5	2.0	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL481602	183374	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	403	4	1	5	2.0	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)cc2)C1	10.1016/j.bmcl.2008.12.042
	44570761	189379	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	NC1CCN(C(=O)C2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL517081	189379	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	NC1CCN(C(=O)C2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	122178179	120750	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1002	29	10	9	3.8	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578008	120750	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1002	29	10	9	3.8	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	24969112	88448	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	7	3.2	Cc1ccc(-c2ccc(S(=O)(=O)Nc3ccnc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364339	88448	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	7	3.2	Cc1ccc(-c2ccc(S(=O)(=O)Nc3ccnc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1	10.6019/CHEMBL2364335
	11540248	88454	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	6	4.9	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364345	88454	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	6	4.9	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11647560	88456	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2cccc3ccccc23)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364347	88456	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2cccc3ccccc23)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196005	88487	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1sc2ccc(F)cc2c1C	10.6019/CHEMBL2364335
	CHEMBL2364378	88487	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1sc2ccc(F)cc2c1C	10.6019/CHEMBL2364335
	69198434	88495	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	488	7	2	8	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccc2OC)s1	10.6019/CHEMBL2364335
	CHEMBL2364386	88495	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	488	7	2	8	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccc2OC)s1	10.6019/CHEMBL2364335
	69198286	88503	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	401	4	2	5	3.9	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cc4ccccc4s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364394	88503	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	401	4	2	5	3.9	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cc4ccccc4s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11562181	88514	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(F)c3F)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364405	88514	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(F)c3F)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196132	88525	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2)s1	10.6019/CHEMBL2364335
	CHEMBL2364416	88525	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2)s1	10.6019/CHEMBL2364335
	69197703	88526	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)cc2)s1	10.6019/CHEMBL2364335
	CHEMBL2364417	88526	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)cc2)s1	10.6019/CHEMBL2364335
	69194443	88547	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2F)cc1	10.6019/CHEMBL2364335
	CHEMBL2364436	88547	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2F)cc1	10.6019/CHEMBL2364335
	11503069	88550	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	439	5	2	4	4.5	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccc4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364439	88550	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	439	5	2	4	4.5	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccc4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11647941	88557	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.4	Cc1cc(-c2ccoc2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	CHEMBL2364446	88557	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.4	Cc1cc(-c2ccoc2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	11576203	88564	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	6	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)CCC(C)(C)O2	10.6019/CHEMBL2364335
	CHEMBL2364453	88564	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	6	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)CCC(C)(C)O2	10.6019/CHEMBL2364335
	11683891	88578	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccn2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364467	88578	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccn2)cc1	10.6019/CHEMBL2364335
	69194380	88602	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	6	2	6	4.0	COc1ccc(N2CCN[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364490	88602	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	6	2	6	4.0	COc1ccc(N2CCN[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	56926783	68716	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	470	4	3	4	2.8	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923632	68716	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	470	4	3	4	2.8	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	156021183	177550	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648308	177550	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156017268	177076	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641472	177076	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156021183	177550	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648308	177550	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44453070	94650	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cncnc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL255401	94650	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cncnc2)cc1	10.1016/j.bmcl.2007.12.021
	44453097	154554	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	452	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccncc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL401891	154554	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	452	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccncc2)cc1	10.1016/j.bmcl.2007.12.021
	44570762	182846	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	414	4	1	5	1.9	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cccnc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL479865	182846	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	414	4	1	5	1.9	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cccnc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL3578013	210017	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	156017268	177076	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641472	177076	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44434114	88988	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnc([C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237060	88988	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnc([C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)n1	10.1016/j.bmcl.2007.07.099
	44450134	161343	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	479	13	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCc1ccccc1	10.1016/j.bmcl.2008.03.059
	CHEMBL415095	161343	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	479	13	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCc1ccccc1	10.1016/j.bmcl.2008.03.059
	44446177	94210	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252448	94210	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL500468	212344	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/s0960-894x(01)00324-9
	44450105	95358	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	507	15	3	8	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2008.03.059
	CHEMBL258762	95358	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	507	15	3	8	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2008.03.059
	44447848	94459	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	547	15	4	11	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccc(OC(F)(F)F)cc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254167	94459	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	547	15	4	11	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccc(OC(F)(F)F)cc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44580031	192468	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	381	7	2	4	3.2	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL522446	192468	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	381	7	2	4	3.2	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL3578013	210017	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	44447845	94437	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	599	14	4	10	2.3	CC(C)(N)C(=O)N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL253966	94437	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	599	14	4	10	2.3	CC(C)(N)C(=O)N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44434119	89476	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	400	10	3	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1	10.1016/j.bmcl.2007.07.099
	CHEMBL237925	89476	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	400	10	3	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1	10.1016/j.bmcl.2007.07.099
	145953855	161965	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167669	161965	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44434121	89478	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL237927	89478	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N	10.1016/j.bmcl.2007.07.099
	162646324	179156	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	688	17	3	9	4.8	CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4744139	179156	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	688	17	3	9	4.8	CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	10721075	15378	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	534	11	2	5	3.8	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1csc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL121960	15378	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	534	11	2	5	3.8	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1csc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	145959787	161735	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	161735	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	16114289	98212	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL277376	98212	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1	10.1021/jm0704550
	56926892	68720	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923636	68720	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	145984632	165838	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	629	5	1	4	8.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4276775	165838	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	629	5	1	4	8.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1	10.1021/acs.jmedchem.8b00794
	155551597	173377	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	974	27	13	11	-1.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4541252	173377	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	974	27	13	11	-1.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	22862448	96730	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(=O)c1ccccc1O2	10.1016/s0960-894x(97)10199-8
	CHEMBL268231	96730	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(=O)c1ccccc1O2	10.1016/s0960-894x(97)10199-8
	22867465	96770	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2	10.1016/s0960-894x(97)10199-8
	CHEMBL268518	96770	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2	10.1016/s0960-894x(97)10199-8
	44301387	11159	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179088	11159	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL59572	11159	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	56926356	68677	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923512	68677	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	10143731	63997	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	543	11	2	5	4.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181156	63997	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	543	11	2	5	4.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	44444558	167214	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	465	4	0	5	4.1	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL430398	167214	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	465	4	0	5	4.1	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2	10.1016/j.bmcl.2007.09.067
	145959007	161707	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163623	161707	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	145959787	161735	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	161735	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	156021766	177553	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648355	177553	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44452826	94938	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	428	5	2	6	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL256809	94938	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	428	5	2	6	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	44452777	95773	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	470	6	2	7	4.0	CC(=O)c1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL260831	95773	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	470	6	2	7	4.0	CC(=O)c1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	11554351	96092	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	6	2.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(N2CCCC2=O)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL262879	96092	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	6	2.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(N2CCCC2=O)cc1	10.1016/j.bmcl.2007.12.021
	11605061	96266	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	462	5	2	6	4.5	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL264170	96266	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	462	5	2	6	4.5	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	44452825	154711	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	472	7	2	7	4.2	CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL402772	154711	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	472	7	2	7	4.2	CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL3578017	210021	0	None	-3	2	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	69197033	88479	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364370	88479	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197513	88494	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	448	6	2	8	3.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364385	88494	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	448	6	2	8	3.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196509	88498	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364389	88498	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11669948	88510	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc(Br)c(C)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364401	88510	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc(Br)c(C)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196071	88568	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	478	6	2	8	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)n2)s1	10.6019/CHEMBL2364335
	CHEMBL2364457	88568	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	478	6	2	8	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)n2)s1	10.6019/CHEMBL2364335
	69194899	88572	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccoc2)c1	10.6019/CHEMBL2364335
	CHEMBL2364461	88572	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccoc2)c1	10.6019/CHEMBL2364335
	44434055	88875	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL236858	88875	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	44436889	152523	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	563	11	3	5	6.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL397594	152523	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	563	11	3	5	6.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44570922	191964	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	415	3	1	4	1.6	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(Br)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL521264	191964	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	415	3	1	4	1.6	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(Br)cc2)C1	10.1016/j.bmcl.2008.12.042
	69196838	88459	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	426	5	2	6	3.2	COc1ccc(NS(=O)(=O)c2cccc3cccnc23)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364350	88459	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	426	5	2	6	3.2	COc1ccc(NS(=O)(=O)c2cccc3cccnc23)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	25211977	186319	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL489818	186319	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	16113580	137353	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm701292s
	CHEMBL376258	137353	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm701292s
	44434111	145750	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL392077	145750	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	15481185	76908	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL207970	76908	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	127048059	139036	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	675	16	6	8	4.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797225	139036	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	675	16	6	8	4.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	16113580	137353	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL376258	137353	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	44450103	95328	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	495	14	3	10	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(C)(=O)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL258551	95328	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	495	14	3	10	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(C)(=O)=O	10.1016/j.bmcl.2008.03.059
	44391032	64514	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	513	8	1	5	5.7	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL182050	64514	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	513	8	1	5	5.7	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	156011736	176849	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	605	7	3	7	3.0	Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4638566	176849	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	605	7	3	7	3.0	Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	44450132	95566	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	447	14	4	9	0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL259712	95566	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	447	14	4	9	0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCCCO	10.1016/j.bmcl.2008.03.059
	145948725	166936	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	885	20	7	9	6.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL4299615	166936	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	885	20	7	9	6.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	44281450	99184	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	573	12	3	8	1.5	COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL284295	99184	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	573	12	3	8	1.5	COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	44281450	99184	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	573	12	3	8	1.5	COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL284295	99184	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	573	12	3	8	1.5	COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	44411584	10206	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161822	10206	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	156015766	176994	0	None	407	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	7	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640438	176994	0	None	407	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	7	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1	10.1021/acs.jmedchem.0c00828
	44411584	10206	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161822	10206	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	22888433	64282	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	535	10	1	5	5.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC1CCCCC1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181735	64282	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	535	10	1	5	5.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC1CCCCC1)C(C)C	10.1016/j.bmcl.2005.02.040
	44579775	186597	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	7	1	3	3.5	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1	10.1016/j.bmcl.2008.07.120
	CHEMBL492230	186597	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	7	1	3	3.5	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1	10.1016/j.bmcl.2008.07.120
	11258291	188515	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL510195	188515	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44579882	192464	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL522426	192464	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	44450044	160555	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	433	13	4	9	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL411699	160555	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	433	13	4	9	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCO	10.1016/j.bmcl.2008.03.059
	56926463	68696	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923611	68696	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	145981687	166024	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	509	5	1	3	6.5	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4279987	166024	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	509	5	1	3	6.5	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44579640	186313	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	354	7	1	4	3.2	COc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL489793	186313	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	354	7	1	4	3.2	COc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	44579686	186408	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	395	8	2	4	3.6	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(NC(C)=O)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL490614	186408	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	395	8	2	4	3.6	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(NC(C)=O)cc1	10.1016/j.bmcl.2008.07.120
	16203238	136585	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	531	9	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1	10.1021/jm070024h
	CHEMBL374757	136585	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	531	9	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1	10.1021/jm070024h
	44390997	122485	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	481	8	1	5	4.6	CC(C)N(C)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL360891	122485	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	481	8	1	5	4.6	CC(C)N(C)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL3578017	210021	0	None	-3	2	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	23661656	168478	0	None	-7	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	564	8	1	4	5.3	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)N2CCCC2=O)CC1	10.1016/j.bmc.2007.05.026
	CHEMBL439560	168478	0	None	-7	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	564	8	1	4	5.3	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)N2CCCC2=O)CC1	10.1016/j.bmc.2007.05.026
	44434074	154135	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL399625	154135	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44434009	166893	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	431	13	3	8	1.1	CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL429799	166893	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	431	13	3	8	1.1	CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	22867312	23666	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	4	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2=O	10.1016/s0960-894x(97)10199-8
	CHEMBL13366	23666	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	4	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2=O	10.1016/s0960-894x(97)10199-8
	162665952	181797	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	688	14	4	10	3.5	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4785149	181797	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	688	14	4	10	3.5	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44434056	144462	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL391088	144462	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44434007	88147	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	390	10	2	9	0.3	COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL235446	88147	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	390	10	2	9	0.3	COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	156021766	177553	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648355	177553	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44391035	122093	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	545	11	1	4	5.3	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1F)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL360247	122093	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	545	11	1	4	5.3	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1F)C(C)C	10.1016/j.bmcl.2005.02.040
	44301512	11917	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1183340	11917	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL291333	11917	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	145979268	166111	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	607	8	1	5	7.4	COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4281647	166111	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	607	8	1	5	7.4	COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	145959007	161707	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163623	161707	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	44580030	186387	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	324	6	1	3	3.2	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1	10.1016/j.bmcl.2008.07.120
	CHEMBL490422	186387	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	324	6	1	3	3.2	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1	10.1016/j.bmcl.2008.07.120
	118718706	114880	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL3350011	114880	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	44301462	11157	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179075	11157	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL58758	11157	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	16113800	137287	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL375972	137287	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	44391015	123038	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1ccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	CHEMBL361802	123038	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1ccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	162677268	182991	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	663	14	3	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4800459	182991	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	663	14	3	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	10507433	16290	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	578	13	3	6	3.5	C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL123430	16290	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	578	13	3	6	3.5	C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	23730458	146039	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	499	14	3	11	0.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCn1ccnc1	10.1021/jm7010595
	CHEMBL392296	146039	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	499	14	3	11	0.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCn1ccnc1	10.1021/jm7010595
	44576247	212451	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL506986	212451	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	168285897	191061	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	273	7	1	2	4.1	CCCCCCCc1cc(=O)c2cc(OC)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	CHEMBL5196194	191061	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	273	7	1	2	4.1	CCCCCCCc1cc(=O)c2cc(OC)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	155529391	170874	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1427	41	20	17	-3.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4463042	170874	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1427	41	20	17	-3.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	145956659	161506	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160434	161506	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	155537651	171750	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1597	47	22	19	-3.8	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4475293	171750	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1597	47	22	19	-3.8	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	145981196	165983	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	627	5	1	6	7.1	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4279344	165983	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	627	5	1	6	7.1	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	145979819	165920	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	655	8	1	6	7.9	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4278185	165920	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	655	8	1	6	7.9	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44434016	89762	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	415	12	3	7	1.5	CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL238228	89762	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	415	12	3	7	1.5	CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	16113692	136712	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	559	11	4	5	5.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	CHEMBL375162	136712	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	559	11	4	5	5.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	24970113	68714	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	580	3	3	5	3.8	C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923629	68714	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	580	3	3	5	3.8	C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL2170777	207620	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CCC[C@H](NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O	10.1021/jm300414b
	145956026	162112	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4169979	162112	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	22862436	10217	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161834	10217	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	10602640	137661	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1016/j.bmc.2007.01.057
	CHEMBL376970	137661	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1016/j.bmc.2007.01.057
	10791616	139006	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL379564	139006	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	10029990	168718	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL441360	168718	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	11526696	71258	13	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1923502	71258	13	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1963249	71258	13	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	10649323	15355	0	None	-	1	Rat	8.3	pEC50	=	8.3	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	508	13	2	5	2.5	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](COCc1ccccc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL121803	15355	0	None	-	1	Rat	8.3	pEC50	=	8.3	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	508	13	2	5	2.5	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](COCc1ccccc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	10841400	16672	0	None	-	1	Rat	8.3	pEC50	=	8.3	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	608	13	3	5	3.7	C[C@H](O)CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL124831	16672	0	None	-	1	Rat	8.3	pEC50	=	8.3	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	608	13	3	5	3.7	C[C@H](O)CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	156009875	176549	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633695	176549	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44444562	94035	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	463	6	1	5	3.5	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)CCc1ccccc1Cl)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251365	94035	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	463	6	1	5	3.5	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)CCc1ccccc1Cl)CC2	10.1016/j.bmcl.2007.09.067
	145956026	162112	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4169979	162112	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	22862436	10217	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161834	10217	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	10602640	137661	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1016/j.bmc.2007.01.057
	CHEMBL376970	137661	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1016/j.bmc.2007.01.057
	10791616	139006	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL379564	139006	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	10029990	168718	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL441360	168718	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	156009875	176549	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633695	176549	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156015766	176994	0	None	407	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	7	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640438	176994	0	None	407	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	7	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1	10.1021/acs.jmedchem.0c00828
	44570967	189576	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL517391	189576	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	24969114	88451	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	506	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364342	88451	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	506	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1Cl	10.6019/CHEMBL2364335
	59007076	88474	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364365	88474	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1	10.6019/CHEMBL2364335
	69197196	88476	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)s1	10.6019/CHEMBL2364335
	CHEMBL2364367	88476	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)s1	10.6019/CHEMBL2364335
	69197071	88515	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	5	4.5	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364406	88515	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	5	4.5	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69194482	88530	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	409	4	2	4	4.1	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1	10.6019/CHEMBL2364335
	CHEMBL2364420	88530	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	409	4	2	4	4.1	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1	10.6019/CHEMBL2364335
	11719784	88567	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1C	10.6019/CHEMBL2364335
	CHEMBL2364456	88567	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1C	10.6019/CHEMBL2364335
	59007054	88599	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	5	3	6	3.9	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2)o1	10.6019/CHEMBL2364335
	CHEMBL2364487	88599	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	5	3	6	3.9	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2)o1	10.6019/CHEMBL2364335
	16114097	78747	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1	10.1021/jm0704550
	CHEMBL2113321	78747	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1	10.1021/jm0704550
	16113710	78751	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1	10.1021/jm0704550
	CHEMBL2113325	78751	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1	10.1021/jm0704550
	23730226	147339	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	449	13	4	10	-0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCO	10.1021/jm7010595
	CHEMBL393329	147339	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	449	13	4	10	-0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCO	10.1021/jm7010595
	71453489	207623	13	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.8b01644
	CHEMBL2170781	207623	13	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.8b01644
	44411632	10207	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161823	10207	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	22888425	62195	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	2	5	4.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(CO)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL178216	62195	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	2	5	4.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(CO)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	44411632	10207	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161823	10207	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL2170782	207624	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44579858	186342	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL490010	186342	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)cc1	10.1016/j.bmcl.2008.07.120
	44579778	186436	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL490801	186436	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	162657606	180535	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	693	15	3	8	5.7	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4760409	180535	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	693	15	3	8	5.7	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	145956659	161506	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160434	161506	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	145950987	162290	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	4	3	5	1.7	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4172848	162290	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	4	3	5	1.7	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21	10.1021/acs.jmedchem.8b00322
	69198313	88470	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	426	5	2	6	3.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccnc12	10.6019/CHEMBL2364335
	CHEMBL2364361	88470	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	426	5	2	6	3.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccnc12	10.6019/CHEMBL2364335
	69195692	88471	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.6019/CHEMBL2364335
	CHEMBL2364362	88471	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.6019/CHEMBL2364335
	69196612	88472	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364363	88472	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)cc1	10.6019/CHEMBL2364335
	11511158	88520	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364411	88520	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69198054	88573	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cc(C)cs2)c1	10.6019/CHEMBL2364335
	CHEMBL2364462	88573	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cc(C)cs2)c1	10.6019/CHEMBL2364335
	69195074	88586	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)nc1	10.6019/CHEMBL2364335
	CHEMBL2364474	88586	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)nc1	10.6019/CHEMBL2364335
	69195546	88596	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c2ccccc12	10.6019/CHEMBL2364335
	CHEMBL2364484	88596	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c2ccccc12	10.6019/CHEMBL2364335
	44580028	192647	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	416	8	1	4	4.5	COc1c(-c2ccccc2)cccc1N(C[C@H]1CCCN1)C(=O)COc1ccccc1	10.1016/j.bmcl.2008.07.120
	CHEMBL523786	192647	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	416	8	1	4	4.5	COc1c(-c2ccccc2)cccc1N(C[C@H]1CCCN1)C(=O)COc1ccccc1	10.1016/j.bmcl.2008.07.120
	44434011	147331	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	465	12	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL393321	147331	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	465	12	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1	10.1016/j.bmcl.2007.07.099
	57390496	68713	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	CHEMBL1923628	68713	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	145988894	166591	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4290680	166591	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44434086	148323	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C/C=C/c2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL394130	148323	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C/C=C/c2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	145950987	162290	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	4	3	5	1.7	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4172848	162290	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	4	3	5	1.7	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21	10.1021/acs.jmedchem.8b00322
	44449924	159398	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	487	12	4	9	1.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)N[C@H]1CC[C@H](O)CC1	10.1016/j.bmcl.2008.03.059
	CHEMBL410730	159398	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	487	12	4	9	1.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)N[C@H]1CC[C@H](O)CC1	10.1016/j.bmcl.2008.03.059
	56926785	68718	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923634	68718	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	44434078	89480	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	513	10	2	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC2Cc3ccccc3N2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237932	89480	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	513	10	2	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC2Cc3ccccc3N2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44434008	146001	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	404	11	2	9	0.7	COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL392268	146001	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	404	11	2	9	0.7	COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	44411913	10216	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161833	10216	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	44268939	30233	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@]2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL13926	30233	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@]2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	44411913	10216	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161833	10216	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	44434015	88063	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL235011	88063	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	44411905	10215	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161832	10215	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	10506325	100771	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	CHEMBL296104	100771	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	16113371	78743	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL2113318	78743	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	162676229	182722	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	715	15	3	10	3.9	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4797064	182722	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	715	15	3	10	3.9	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL3578005	210012	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(N)=O	10.1021/jm501702q
	44348031	112590	0	None	-	1	Rat	8.2	pEC50	=	8.2	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	618	14	3	5	4.3	C[C@@H](O)CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL331303	112590	0	None	-	1	Rat	8.2	pEC50	=	8.2	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	618	14	3	5	4.3	C[C@@H](O)CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44411905	10215	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161832	10215	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44437953	10226	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	522	9	3	6	1.5	NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21	10.1016/j.bmc.2007.01.057
	CHEMBL1162062	10226	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	522	9	3	6	1.5	NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21	10.1016/j.bmc.2007.01.057
	10506325	100771	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	CHEMBL296104	100771	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	44436857	145123	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	594	12	4	7	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL391588	145123	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	594	12	4	7	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	156021787	177569	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648799	177569	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	10006735	116512	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	515	10	3	6	2.0	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL33892	116512	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	515	10	3	6	2.0	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1	10.1016/j.bmc.2007.01.057
	10006735	116512	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	515	10	3	6	2.0	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL33892	116512	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	515	10	3	6	2.0	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1	10.1016/j.bmc.2007.01.057
	156021787	177569	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648799	177569	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	11712108	160761	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	451	6	2	5	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL412303	160761	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	451	6	2	5	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	44571003	191989	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	445	4	1	5	3.0	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL521439	191989	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	445	4	1	5	3.0	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL3578005	210012	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(N)=O	10.1021/jm501702q
	69196876	88461	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	7	2.9	COc1ccc(NS(=O)(=O)c2ccc(-n3cccn3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364352	88461	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	7	2.9	COc1ccc(NS(=O)(=O)c2ccc(-n3cccn3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11562329	88500	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	495	8	2	6	4.5	COCc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.6019/CHEMBL2364335
	CHEMBL2364391	88500	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	495	8	2	6	4.5	COCc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.6019/CHEMBL2364335
	69196868	88504	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	427	5	2	5	4.4	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364395	88504	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	427	5	2	5	4.4	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69196990	88560	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	480	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1C	10.6019/CHEMBL2364335
	CHEMBL2364449	88560	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	480	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1C	10.6019/CHEMBL2364335
	69195880	88577	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(C)c1	10.6019/CHEMBL2364335
	CHEMBL2364466	88577	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(C)c1	10.6019/CHEMBL2364335
	11518463	88580	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1cc(-c2cc(C)cs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	CHEMBL2364469	88580	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1cc(-c2cc(C)cs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	69195024	88604	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	461	5	3	6	4.2	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364492	88604	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	461	5	3	6	4.2	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	44390922	121632	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1cccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	CHEMBL359686	121632	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1cccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	23631026	166896	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelinAgonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelin	ChEMBL	443	5	1	5	5.3	Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1CC1CCCNC1	10.1021/jm070071+
	CHEMBL429817	166896	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelinAgonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelin	ChEMBL	443	5	1	5	5.3	Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1CC1CCCNC1	10.1021/jm070071+
	CHEMBL2170779	207621	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at FLAG-tagged human ghrelin receptor Ser123:Ala mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor Ser123:Ala mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44447842	94577	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.6	CC(C)(N)C(=O)N[C@H](COCc1cc(Cl)cc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254972	94577	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.6	CC(C)(N)C(=O)N[C@H](COCc1cc(Cl)cc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44579804	186482	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL491220	186482	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	145948708	166935	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	886	20	7	10	5.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL4299606	166935	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	886	20	7	10	5.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	121879	2204	19	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1016/s0960-894x(97)10199-8
	5868	2204	19	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1016/s0960-894x(97)10199-8
	CHEMBL308716	2204	19	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1016/s0960-894x(97)10199-8
	44268996	165910	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL427806	165910	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2)C1	10.1016/s0960-894x(97)10199-8
	122178180	120751	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1130	35	12	11	3.4	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578009	120751	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1130	35	12	11	3.4	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	44579959	183690	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL483865	183690	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1	10.1016/j.bmcl.2008.07.120
	44454117	155016	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL404336	155016	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	162677361	182927	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	685	16	4	8	4.7	COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4799766	182927	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	685	16	4	8	4.7	COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL2170700	207615	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(C(C)(C)C)cc1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44444570	154230	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	456	5	1	7	3.0	COc1cc2c(cc1N1CCNCC1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL400125	154230	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	456	5	1	7	3.0	COc1cc2c(cc1N1CCNCC1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	156017532	177334	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645072	177334	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11662746	97364	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	467	7	2	6	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Oc2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL271947	97364	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	467	7	2	6	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Oc2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	122178180	120751	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1130	35	12	11	3.4	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578009	120751	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1130	35	12	11	3.4	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578007	210014	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)O	10.1021/jm501702q
	16750162	88450	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	474	6	2	7	3.8	COc1ncc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)c(F)c1	10.6019/CHEMBL2364335
	CHEMBL2364341	88450	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	474	6	2	7	3.8	COc1ncc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)c(F)c1	10.6019/CHEMBL2364335
	11568467	88460	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364351	88460	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197136	88561	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2ccccc2F)s1	10.6019/CHEMBL2364335
	CHEMBL2364450	88561	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2ccccc2F)s1	10.6019/CHEMBL2364335
	69195304	88575	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	4	2	4	3.9	Cc1cc(S(=O)(=O)Nc2cc(N3C[C@H](C)N[C@H](C)C3)ccc2F)ccc1Br	10.6019/CHEMBL2364335
	CHEMBL2364464	88575	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	4	2	4	3.9	Cc1cc(S(=O)(=O)Nc2cc(N3C[C@H](C)N[C@H](C)C3)ccc2F)ccc1Br	10.6019/CHEMBL2364335
	145949880	162241	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172217	162241	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	16114099	136700	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	559	10	4	5	5.5	Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL375103	136700	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	559	10	4	5	5.5	Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	44269018	96899	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc32)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL269447	96899	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc32)C1	10.1016/s0960-894x(97)10199-8
	145949880	162241	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172217	162241	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	156015598	177003	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	486	7	4	6	0.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640573	177003	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	486	7	4	6	0.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1	10.1021/acs.jmedchem.0c00828
	44452827	94982	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	5	2	7	3.7	C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)ccc2C#N)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL257019	94982	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	5	2	7	3.7	C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)ccc2C#N)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	46882582	5678	0	None	-125	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	466	5	2	5	3.9	CC1(C)CCc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc2O1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078490	5678	0	None	-125	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	466	5	2	5	3.9	CC1(C)CCc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc2O1	10.1016/j.bmcl.2009.09.027
	145988647	166519	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4289530	166519	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44454367	94817	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	CHEMBL256235	94817	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	16113691	136196	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm0704550
	CHEMBL374073	136196	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm0704550
	16113691	136196	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	CHEMBL374073	136196	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	22867380	29207	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	3	3.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	CHEMBL13841	29207	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	3	3.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	2098	3638	31	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	36511	3638	31	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	3805	3638	31	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	3835	3638	31	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	CHEMBL235363	3638	31	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	155561671	175091	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	817	22	11	9	-0.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4581511	175091	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	817	22	11	9	-0.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	44434073	89170	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL237507	89170	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	145981794	166143	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	567	6	1	5	6.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4282394	166143	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	567	6	1	5	6.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	56926173	68670	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm1012374
	CHEMBL1923501	68670	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm1012374
	44301389	11170	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179118	11170	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL61292	11170	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	156015598	177003	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	486	7	4	6	0.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640573	177003	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	486	7	4	6	0.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1	10.1021/acs.jmedchem.0c00828
	156017532	177334	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645072	177334	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	10100708	11929	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL1183387	11929	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL294408	11929	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	44579756	186241	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL489370	186241	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	145958487	161635	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21	10.1021/acs.jmedchem.8b00322
	CHEMBL4162545	161635	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21	10.1021/acs.jmedchem.8b00322
	156016840	177057	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	621	7	3	7	3.4	Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641215	177057	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	621	7	3	7	3.4	Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL2170779	207621	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	71453489	207623	13	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Thr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Thr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	207623	13	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Thr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Thr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	10209618	63169	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	555	11	1	5	5.4	CC(=O)c1ccccc1C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL179978	63169	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	555	11	1	5	5.4	CC(=O)c1ccccc1C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44391041	63990	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	591	11	1	6	5.1	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)Cc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181123	63990	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	591	11	1	6	5.1	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)Cc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	10600702	140805	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL383526	140805	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	10600702	140805	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL383526	140805	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	9868878	96094	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	460	14	4	9	-0.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(N)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL262884	96094	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	460	14	4	9	-0.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(N)=O	10.1016/j.bmcl.2008.03.059
	11306502	63311	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180094	63311	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	22888395	63574	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	513	10	1	4	5.2	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180540	63574	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	513	10	1	4	5.2	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	156021942	177649	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649860	177649	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	16113248	78754	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL2113328	78754	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	23730342	89472	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	511	13	4	10	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCc1cccc(O)c1	10.1021/jm7010595
	CHEMBL237916	89472	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	511	13	4	10	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCc1cccc(O)c1	10.1021/jm7010595
	145958487	161635	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21	10.1021/acs.jmedchem.8b00322
	CHEMBL4162545	161635	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21	10.1021/acs.jmedchem.8b00322
	156010733	176506	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633062	176506	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156013130	176928	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639514	176928	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156016840	177057	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	621	7	3	7	3.4	Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641215	177057	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	621	7	3	7	3.4	Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156021942	177649	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649860	177649	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44570920	183351	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL481408	183351	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	44571005	183465	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	431	4	1	5	2.6	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CCCNCC3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL482204	183465	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	431	4	1	5	2.6	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CCCNCC3)cc2)o1	10.1016/j.bmcl.2008.12.042
	11539144	88465	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1	10.6019/CHEMBL2364335
	CHEMBL2364356	88465	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1	10.6019/CHEMBL2364335
	69197315	88481	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364372	88481	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	11683663	88507	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364398	88507	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1	10.6019/CHEMBL2364335
	11583902	88548	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	484	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364437	88548	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	484	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1F	10.6019/CHEMBL2364335
	69198030	88553	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	5	5.2	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364442	88553	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	5	5.2	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69197149	88565	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)c(C)c1	10.6019/CHEMBL2364335
	CHEMBL2364454	88565	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)c(C)c1	10.6019/CHEMBL2364335
	69196669	88590	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	456	6	2	7	3.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)nc1	10.6019/CHEMBL2364335
	CHEMBL2364478	88590	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	456	6	2	7	3.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)nc1	10.6019/CHEMBL2364335
	10032659	11946	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL1183505	11946	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL301259	11946	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	44450137	95854	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	465	12	3	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)Nc1ccccc1	10.1016/j.bmcl.2008.03.059
	CHEMBL261234	95854	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	465	12	3	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)Nc1ccccc1	10.1016/j.bmcl.2008.03.059
	127046472	139164	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	CHEMBL3798056	139164	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	127046472	139164	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayInverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798056	139164	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayInverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	145988286	166653	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	542	6	1	6	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4291718	166653	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	542	6	1	6	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL3578007	210014	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)O	10.1021/jm501702q
	CHEMBL61663	214062	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/s0960-894x(01)00324-9
	24180592	96565	0	None	1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	CHEMBL266647	96565	0	None	1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	162663868	181406	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	672	14	3	9	3.8	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4780408	181406	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	672	14	3	9	3.8	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	145986080	165899	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	489	5	1	3	6.2	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4277793	165899	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	489	5	1	3	6.2	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	168274297	189985	0	None	-	1	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	299	6	1	1	5.3	CCCCCCCc1cc(=O)c2cc(C(C)(C)C)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	CHEMBL5180310	189985	0	None	-	1	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	299	6	1	1	5.3	CCCCCCCc1cc(=O)c2cc(C(C)(C)C)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	127047523	139533	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	859	20	7	9	6.0	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3800422	139533	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	859	20	7	9	6.0	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1	10.1016/j.bmcl.2016.04.003
	44434118	147646	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	467	14	3	9	0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL393570	147646	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	467	14	3	9	0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	44446187	94184	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252255	94184	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	145959787	161735	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	161735	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	155557019	174015	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174015	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	56926893	68721	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	10.1021/jm2007062
	CHEMBL1923637	68721	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	10.1021/jm2007062
	44437963	200407	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	452	6	1	3	4.5	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21	10.1016/j.bmc.2007.01.057
	CHEMBL608826	200407	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	452	6	1	3	4.5	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21	10.1016/j.bmc.2007.01.057
	44437963	200407	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	452	6	1	3	4.5	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21	10.1016/j.bmc.2007.01.057
	CHEMBL608826	200407	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	452	6	1	3	4.5	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21	10.1016/j.bmc.2007.01.057
	44579881	186254	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	CHEMBL489402	186254	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	24180646	147650	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
	CHEMBL393576	147650	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
	24180646	147650	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	CHEMBL393576	147650	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	145959787	161735	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	161735	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	46882520	5779	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	430	5	2	4	3.8	Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1Cl	10.1016/j.bmcl.2009.09.027
	CHEMBL1079311	5779	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	430	5	2	4	3.8	Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1Cl	10.1016/j.bmcl.2009.09.027
	46882458	5901	0	None	-31	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1080046	5901	0	None	-31	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL3578016	210020	0	None	-15	2	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	59007057	88464	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	6	2.8	COc1ccc(NS(=O)(=O)c2ccc(N3CCCC3=O)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364355	88464	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	6	2.8	COc1ccc(NS(=O)(=O)c2ccc(N3CCCC3=O)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11597905	88518	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	5	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364409	88518	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	5	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69198135	88549	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	484	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)c(F)c1	10.6019/CHEMBL2364335
	CHEMBL2364438	88549	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	484	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)c(F)c1	10.6019/CHEMBL2364335
	11711997	88566	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	446	5	2	7	2.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)OCCN2C	10.6019/CHEMBL2364335
	CHEMBL2364455	88566	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	446	5	2	7	2.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)OCCN2C	10.6019/CHEMBL2364335
	44452778	159231	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	499	6	2	7	3.5	C[C@H]1CN(c2ccc(C(=O)N(C)C)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL410527	159231	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	499	6	2	7	3.5	C[C@H]1CN(c2ccc(C(=O)N(C)C)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	10437444	112383	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	546	11	2	4	3.8	CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL330989	112383	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	546	11	2	4	3.8	CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	24969603	68712	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	520	3	3	5	2.4	Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1	10.1021/jm2007062
	CHEMBL1923627	68712	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	520	3	3	5	2.4	Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1	10.1021/jm2007062
	162649450	179474	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	725	14	3	10	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4747770	179474	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	725	14	3	10	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	156013130	176928	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639514	176928	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44450100	160108	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	511	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCO)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL411330	160108	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	511	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCO)c1	10.1016/j.bmcl.2008.03.059
	44411720	10210	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161826	10210	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	44411902	10214	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161831	10214	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	44411720	10210	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161826	10210	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	44411902	10214	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161831	10214	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	162656896	180278	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	669	14	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4757313	180278	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	669	14	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1	10.1021/acs.jmedchem.9b02122
	44436883	145620	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	604	11	6	7	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1	10.1021/jm0704550
	CHEMBL391980	145620	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	604	11	6	7	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1	10.1021/jm0704550
	156010733	176506	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633062	176506	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	10745674	167391	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	572	13	3	5	3.5	C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL431668	167391	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	572	13	3	5	3.5	C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44579776	192648	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	7	1	3	3.5	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL523795	192648	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	7	1	3	3.5	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	127048061	139206	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	903	24	7	11	5.9	COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798337	139206	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	903	24	7	11	5.9	COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	23730340	89311	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	504	15	4	10	0.4	CC(=O)NCCCCNC(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1021/jm7010595
	CHEMBL237700	89311	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	504	15	4	10	0.4	CC(=O)NCCCCNC(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1021/jm7010595
	56926175	68671	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923504	68671	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	145992835	166281	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4285075	166281	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	56925343	68724	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923640	68724	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	145986870	166587	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	505	6	1	4	5.9	COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4290627	166587	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	505	6	1	4	5.9	COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	44434054	88874	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2cccc(NS(C)(=O)=O)c2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL236857	88874	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2cccc(NS(C)(=O)=O)c2)n1	10.1016/j.bmcl.2007.07.099
	44446178	154584	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL402023	154584	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL3578016	210020	0	None	-15	2	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	162648837	179258	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	706	15	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4745116	179258	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	706	15	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44391024	63954	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	527	11	1	4	5.2	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180992	63954	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	527	11	1	4	5.2	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	10745674	167391	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	572	13	3	5	3.5	C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL431668	167391	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	572	13	3	5	3.5	C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44391021	19253	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	569	12	1	5	5.3	CC(=O)C(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	CHEMBL129637	19253	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	569	12	1	5	5.3	CC(=O)C(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	CHEMBL2170696	207611	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	23730343	89473	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	475	12	3	10	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NC[C@H]1CCCO1	10.1021/jm7010595
	CHEMBL237917	89473	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	475	12	3	10	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NC[C@H]1CCCO1	10.1021/jm7010595
	22888359	63585	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	520	10	1	6	4.8	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C#N)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180591	63585	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	520	10	1	6	4.8	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C#N)C(C)C	10.1016/j.bmcl.2005.02.040
	16114514	78748	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1	10.1021/jm0704550
	CHEMBL2113322	78748	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1	10.1021/jm0704550
	44579843	184170	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL485092	184170	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	44579643	186189	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	338	7	1	3	3.2	CC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL488971	186189	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	338	7	1	3	3.2	CC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44579822	191926	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL520953	191926	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1	10.1016/j.bmcl.2008.07.120
	44579755	186360	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	8	1	3	3.6	CCC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL490186	186360	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	8	1	3	3.6	CCC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44580032	186252	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	363	7	1	4	3.3	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL489398	186252	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	363	7	1	4	3.3	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1	10.1016/j.bmcl.2008.07.120
	145991945	166262	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	4	7.8	CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4284715	166262	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	4	7.8	CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1	10.1021/acs.jmedchem.8b00794
	145992253	166375	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	595	6	1	6	6.4	COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4286849	166375	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	595	6	1	6	6.4	COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL2170702	207617	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	145993313	166339	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	577	7	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4286101	166339	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	577	7	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	16114008	84422	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL223532	84422	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL501261	212364	19	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.8b01644
	9848305	144919	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccc(NS(C)(=O)=O)cc2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL391429	144919	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccc(NS(C)(=O)=O)cc2)n1	10.1016/j.bmcl.2007.07.099
	44434050	144917	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL391428	144917	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL3578015	210019	0	None	-33	2	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	CHEMBL369482	210416	0	None	-	0	Rat	8.0	pED50	=	8	Functional	In vitro effective dose was measured for the growth hormone release in rat pituitary cellsIn vitro effective dose was measured for the growth hormone release in rat pituitary cells	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cn1ccnc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/S0960-894X(01)80239-0
	44269087	97775	0	None	-	1	Rat	6.7	pED50	=	6.7	Functional	In vitro effective dose was measured for the growth hormone release in rat pituitary cellsIn vitro effective dose was measured for the growth hormone release in rat pituitary cells	ChEMBL	553	10	4	7	3.2	CC(C)(NCCCO)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O	10.1016/S0960-894X(01)80239-0
	CHEMBL274341	97775	0	None	-	1	Rat	6.7	pED50	=	6.7	Functional	In vitro effective dose was measured for the growth hormone release in rat pituitary cellsIn vitro effective dose was measured for the growth hormone release in rat pituitary cells	ChEMBL	553	10	4	7	3.2	CC(C)(NCCCO)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O	10.1016/S0960-894X(01)80239-0
	70691550	72853	0	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	572	8	2	5	5.1	Cc1cc(F)ccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL2011825	72853	0	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	572	8	2	5	5.1	Cc1cc(F)ccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	16114292	96486	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL266063	96486	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL509976	213804	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	25260901	112981	1	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	577	5	2	9	3.6	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	CHEMBL3319405	112981	1	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	577	5	2	9	3.6	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	71456897	81438	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	513	5	2	3	5.7	CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164507	81438	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	513	5	2	3	5.7	CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	70691551	72854	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	568	8	2	5	5.3	Cc1cccc(C)c1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL2011826	72854	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	568	8	2	5	5.3	Cc1cccc(C)c1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	25261382	112942	0	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Partial agonist activity at GHS-R1a (unknown origin)Partial agonist activity at GHS-R1a (unknown origin)	ChEMBL	535	7	2	8	3.3	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	CHEMBL3319215	112942	0	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Partial agonist activity at GHS-R1a (unknown origin)Partial agonist activity at GHS-R1a (unknown origin)	ChEMBL	535	7	2	8	3.3	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	11431274	76991	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	467	9	3	8	3.8	CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL208424	76991	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	467	9	3	8	3.8	CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11577349	64900	1	None	-	1	Human	8.0	pIC50	=	8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	529	9	1	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL182655	64900	1	None	-	1	Human	8.0	pIC50	=	8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	529	9	1	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1	10.1016/j.bmcl.2004.06.060
	11351838	77297	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	468	8	4	6	4.9	CC(NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1)c1ccccc1	10.1021/jm060461g
	CHEMBL208842	77297	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	468	8	4	6	4.9	CC(NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1)c1ccccc1	10.1021/jm060461g
	11712151	75640	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	453	9	3	7	4.8	CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205470	75640	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	453	9	3	7	4.8	CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	11713497	122721	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	531	9	1	6	6.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL361349	122721	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	531	9	1	6	6.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1	10.1016/j.bmcl.2004.11.075
	44409757	140793	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	506	8	3	8	4.1	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383454	140793	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	506	8	3	8	4.1	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2006.01.012
	127046807	139410	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799671	139410	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	3676358	5459	4	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	409	3	1	2	4.4	O=C(c1ccc(-c2ccccc2)cc1)N1CCN(C(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/j.bmcl.2010.01.043
	CHEMBL1076586	5459	4	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	409	3	1	2	4.4	O=C(c1ccc(-c2ccccc2)cc1)N1CCN(C(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/j.bmcl.2010.01.043
	122182047	121488	0	None	-67	2	Rat	7.0	pIC50	=	7	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593636	121488	0	None	-67	2	Rat	7.0	pIC50	=	7	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	122178603	120825	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581036	120825	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	11649248	66337	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	515	9	1	5	7.2	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185399	66337	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	515	9	1	5	7.2	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	44395020	123514	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	507	9	1	5	6.1	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL363021	123514	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	507	9	1	5	6.1	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1	10.1016/j.bmcl.2004.06.060
	44389262	121518	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	479	6	2	4	6.1	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359506	121518	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	479	6	2	4	6.1	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1	10.1016/j.bmcl.2004.11.075
	145993628	166837	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	483	4	1	2	6.1	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4295148	166837	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	483	4	1	2	6.1	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11211892	79806	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	405	8	3	6	4.0	CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL213703	79806	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	405	8	3	6	4.0	CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	122178611	120834	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581044	120834	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	11846624	77563	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	490	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL209443	77563	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	490	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	11846463	138712	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	422	5	2	8	2.7	CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL378909	138712	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	422	5	2	8	2.7	CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	11430392	76371	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	431	6	3	7	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1	10.1021/jm0510934
	CHEMBL206588	76371	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	431	6	3	7	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1	10.1021/jm0510934
	57797614	72845	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	558	8	2	5	4.8	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011817	72845	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	558	8	2	5	4.8	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	44409801	76380	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	5	3	7	3.6	CC(C)(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206638	76380	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	5	3	7	3.6	CC(C)(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11523411	75204	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	363	6	4	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1	10.1021/jm0510934
	CHEMBL204511	75204	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	363	6	4	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1	10.1021/jm0510934
	11537800	75216	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	361	6	3	6	3.7	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL204564	75216	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	361	6	3	6	3.7	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1	10.1021/jm0510934
	71453392	81435	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.2	CN(C)[C@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	CHEMBL2164504	81435	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.2	CN(C)[C@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	71456910	81489	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	480	5	2	4	3.6	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164823	81489	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	480	5	2	4	3.6	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	71460578	81496	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)ccc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164830	81496	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)ccc32)CC1	10.1016/j.bmc.2012.07.018
	122178612	120835	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581045	120835	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL507636	212662	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1074/jbc.m609796200
	56942387	139132	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797857	139132	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	145991822	166406	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	6.8	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4287267	166406	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	6.8	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	11676995	65831	1	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	461	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL184258	65831	1	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	461	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1	10.1016/j.bmcl.2004.06.060
	127048038	139442	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799862	139442	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	71458746	81425	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1ccc2c(c1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2	10.1016/j.bmc.2012.07.018
	CHEMBL2164493	81425	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1ccc2c(c1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2	10.1016/j.bmc.2012.07.018
	145992142	166218	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	475	4	2	3	5.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4283858	166218	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	475	4	2	3	5.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	71460565	81427	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2012.07.018
	CHEMBL2164495	81427	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2012.07.018
	11538533	74651	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL203280	74651	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	46880462	6190	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081648	6190	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)c1	10.1016/j.bmcl.2010.01.043
	70693641	72856	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	538	8	2	5	4.4	O=C1CN([C@@H](C(=O)NC2CCN(Cc3ccccc3)CC2)C2CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011828	72856	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	538	8	2	5	4.4	O=C1CN([C@@H](C(=O)NC2CCN(Cc3ccccc3)CC2)C2CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1	10.1016/j.bmcl.2012.01.014
	44409756	76414	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	492	8	4	8	4.1	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206820	76414	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	492	8	4	8	4.1	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46865987	7516	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	3	4.4	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1087908	7516	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	3	4.4	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	46880772	5834	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1079624	5834	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11538534	74664	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL203373	74664	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	145986870	166587	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	505	6	1	4	5.9	COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4290627	166587	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	505	6	1	4	5.9	COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	127046806	139403	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799604	139403	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	122178613	120836	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581046	120836	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	145981196	165983	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	627	5	1	6	7.1	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4279344	165983	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	627	5	1	6	7.1	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	46880814	6300	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	413	3	2	3	3.5	C[C@H]1CN(C(=O)c2ccc(-c3cn[nH]c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082190	6300	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	413	3	2	3	3.5	C[C@H]1CN(C(=O)c2ccc(-c3cn[nH]c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178616	120838	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581048	120838	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	145986461	166660	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4291926	166660	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	71451551	81439	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	460	5	2	4	3.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164508	81439	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	460	5	2	4	3.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1	10.1016/j.bmc.2012.07.018
	46880727	6068	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	458	3	1	3	4.9	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080939	6068	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	458	3	1	3	4.9	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122182190	121495	0	None	-8	2	Rat	7.9	pIC50	=	7.9	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	CHEMBL3593815	121495	0	None	-8	2	Rat	7.9	pIC50	=	7.9	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	44409840	75989	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	500	7	3	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc43)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205896	75989	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	500	7	3	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc43)cc2)cc1	10.1016/j.bmcl.2006.01.012
	127047362	139189	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798204	139189	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	145989916	166193	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	491	5	2	4	5.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(O)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4283454	166193	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	491	5	2	4	5.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(O)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	127048038	139442	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799862	139442	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	46880673	6028	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	507	4	1	3	5.7	C[C@H]1CN(C(=O)c2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080755	6028	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	507	4	1	3	5.7	C[C@H]1CN(C(=O)c2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11455251	160767	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	523	8	3	7	5.0	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL412362	160767	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	523	8	3	7	5.0	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	44409611	74338	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	463	6	3	7	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC4CCC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203019	74338	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	463	6	3	7	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC4CCC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11221946	140315	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	CHEMBL381942	140315	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	44409839	75905	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	412	7	4	8	2.0	CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205847	75905	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	412	7	4	8	2.0	CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	71460576	81493	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3c(Cl)cc(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164828	81493	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3c(Cl)cc(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL509976	213804	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	11692087	62663	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178610	62663	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.11.075
	44409758	75621	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	411	6	3	7	3.4	CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205374	75621	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	411	6	3	7	3.4	CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409661	75643	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	423	6	3	7	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205484	75643	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	423	6	3	7	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46880724	6181	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	437	3	1	2	5.1	Cc1cc(-c2ccccc2)ccc1C(=O)N1CCN(C(=O)c2ccc3cc[nH]c3c2)[C@@H](C)C1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081611	6181	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	437	3	1	2	5.1	Cc1cc(-c2ccccc2)ccc1C(=O)N1CCN(C(=O)c2ccc3cc[nH]c3c2)[C@@H](C)C1	10.1016/j.bmcl.2010.01.043
	71455105	81492	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	432	4	2	4	2.6	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)ccc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164827	81492	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	432	4	2	4	2.6	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)ccc32)CC1	10.1016/j.bmc.2012.07.018
	11221946	140315	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm060461g
	CHEMBL381942	140315	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm060461g
	44410003	75828	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	468	10	4	8	3.5	CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205794	75828	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	468	10	4	8	3.5	CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46880811	5921	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3cccnc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080162	5921	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3cccnc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	70687379	72851	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1cccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)c1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011823	72851	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1cccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)c1	10.1016/j.bmcl.2012.01.014
	44394974	66677	1	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	515	9	1	5	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL186974	66677	1	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	515	9	1	5	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL3586019	210054	4	None	-	1	Rat	6.8	pIC50	=	6.8	Functional	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by inositol phosphate turnover assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by inositol phosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1016/j.bmcl.2015.04.040
	46880567	6310	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3cccc(F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082210	6310	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3cccc(F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	71460564	81424	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	488	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(C(C)(C)C)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164492	81424	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	488	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(C(C)(C)C)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	145992854	166313	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4285747	166313	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C2)ncn1	10.1021/acs.jmedchem.8b00794
	44394833	126304	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	542	9	1	5	6.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL365460	126304	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	542	9	1	5	6.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL509976	213804	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	CHEMBL509976	213804	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	CHEMBL509976	213804	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	127047654	139447	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799883	139447	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	145993758	166762	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	490	5	2	4	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(N)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4294024	166762	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	490	5	2	4	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(N)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	145993528	166764	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	561	5	1	4	6.6	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4294083	166764	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	561	5	1	4	6.6	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL444131	212181	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		NC(=O)CNC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12	10.1074/jbc.m609796200
	11476589	75635	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205451	75635	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	11329138	64129	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationAntagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilization	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1016/j.bmcl.2012.01.014
	CHEMBL181350	64129	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationAntagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilization	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1016/j.bmcl.2012.01.014
	70681022	72860	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	568	8	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(NC(C)(C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011833	72860	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	568	8	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(NC(C)(C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL509976	213804	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	122178611	120834	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581044	120834	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	46880675	6066	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2F)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080927	6066	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2F)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11612155	140478	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL382375	140478	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	328912	62247	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	505	5	1	4	7.0	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C	10.1016/j.bmcl.2004.11.075
	CHEMBL178266	62247	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	505	5	1	4	7.0	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C	10.1016/j.bmcl.2004.11.075
	70685218	72848	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	574	8	2	5	5.3	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3cccc(Cl)c3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011820	72848	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	574	8	2	5	5.3	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3cccc(Cl)c3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	145981794	166143	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	567	6	1	5	6.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4282394	166143	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	567	6	1	5	6.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11649239	66008	1	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	514	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185057	66008	1	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	514	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL501261	212364	19	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O	10.1074/jbc.m609796200
	1744826	62669	17	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL178668	62669	17	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.06.060
	11282247	165373	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL425048	165373	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	11282247	165373	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL425048	165373	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	1744826	62669	17	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178668	62669	17	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44409831	75346	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	503	6	3	9	3.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3COc4ccccc4O3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204776	75346	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	503	6	3	9	3.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3COc4ccccc4O3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145979268	166111	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	607	8	1	5	7.4	COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4281647	166111	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	607	8	1	5	7.4	COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44409678	140686	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	490	9	3	9	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL382853	140686	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	490	9	3	9	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11349789	78363	1	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	389	7	3	6	3.4	Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL211265	78363	1	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	389	7	3	6	3.4	Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	11692087	62663	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL178610	62663	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	11677781	124538	1	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	502	9	1	5	5.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL364430	124538	1	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	502	9	1	5	5.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1	10.1016/j.bmcl.2004.06.060
	11538533	74651	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm060461g
	CHEMBL203280	74651	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm060461g
	11154823	75676	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	436	8	3	7	4.5	N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205660	75676	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	436	8	3	7	4.5	N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	56942244	124677	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645259	124677	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	44409994	75829	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	409	6	3	7	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205796	75829	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	409	6	3	7	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44576247	212451	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212451	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	44395002	65855	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	534	9	1	5	5.6	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL184368	65855	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	534	9	1	5	5.6	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1	10.1016/j.bmcl.2004.06.060
	11646276	75581	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	CHEMBL205136	75581	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	127046807	139410	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799671	139410	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	16113695	136503	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL374643	136503	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	145987684	166724	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	4	7.8	CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4293331	166724	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	4	7.8	CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	122178602	120824	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581035	120824	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	70681020	72857	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011829	72857	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	56942098	124673	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645255	124673	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942242	124675	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645257	124675	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	127046956	139427	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799776	139427	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	66788278	124672	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645254	124672	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127046956	139427	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799776	139427	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	57797640	72879	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	510	9	1	3	7.1	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCCc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011892	72879	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	510	9	1	3	7.1	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCCc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	46880628	5955	0	None	4	2	Rat	8.7	pIC50	=	8.7	Functional	Inhibition of rat GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayInhibition of rat GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080389	5955	0	None	4	2	Rat	8.7	pIC50	=	8.7	Functional	Inhibition of rat GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayInhibition of rat GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178606	120828	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581039	120828	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	46880629	5981	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	457	3	1	2	5.5	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080556	5981	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	457	3	1	2	5.5	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178606	120828	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581039	120828	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	70681021	72859	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.2	CC(C)[C@H](C(=O)N1CCC(N[C@H](C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011832	72859	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.2	CC(C)[C@H](C(=O)N1CCC(N[C@H](C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	70691552	72861	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	560	8	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(N[C@H](C)C2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011834	72861	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	560	8	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(N[C@H](C)C2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	44576247	212451	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Inverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212451	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Inverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	122178607	120830	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581040	120830	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	46880631	6058	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	437	3	1	2	5.1	Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080907	6058	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	437	3	1	2	5.1	Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	46880726	6067	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080938	6067	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	70689441	72878	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	525	9	2	4	6.1	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011891	72878	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	525	9	2	4	6.1	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	145988582	166738	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	555	4	1	2	7.4	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#C[Si](C)(C)C)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4293608	166738	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	555	4	1	2	7.4	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#C[Si](C)(C)C)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	122178610	120833	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581043	120833	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	44409666	75534	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	437	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204897	75534	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	437	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44576247	212451	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212451	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL500703	212349	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1074/jbc.m609796200
	44409802	76391	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	9	3	7	4.1	CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206687	76391	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	9	3	7	4.1	CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122178613	120836	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581046	120836	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	71458747	81426	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2012.07.018
	CHEMBL2164494	81426	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2012.07.018
	56942244	124677	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645259	124677	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	11537683	75176	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	354	5	3	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1	10.1021/jm0510934
	CHEMBL204352	75176	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	354	5	3	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1	10.1021/jm0510934
	71449740	81428	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	480	4	2	4	3.5	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmc.2012.07.018
	CHEMBL2164497	81428	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	480	4	2	4	3.5	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmc.2012.07.018
	122178601	120823	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581034	120823	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	11337482	76287	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	CHEMBL206399	76287	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	122178614	120837	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581047	120837	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	44389168	64542	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	457	4	1	4	5.8	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1	10.1016/j.bmcl.2004.11.075
	CHEMBL182154	64542	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	457	4	1	4	5.8	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1	10.1016/j.bmcl.2004.11.075
	145991389	166451	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	6	1	6	6.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4288108	166451	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	6	1	6	6.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	145990051	166402	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	499	5	1	2	7.0	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4287218	166402	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	499	5	1	2	7.0	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	44410012	137871	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	9	3	7	4.1	CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL377305	137871	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	9	3	7	4.1	CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	71462272	81433	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	528	5	2	4	4.6	CN(C)C1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164502	81433	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	528	5	2	4	4.6	CN(C)C1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	71451563	81498	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	500	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164832	81498	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	500	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	145988286	166653	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	542	6	1	6	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4291718	166653	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	542	6	1	6	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	46880813	6299	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	4	4.4	Cc1noc(C)c1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082189	6299	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	4	4.4	Cc1noc(C)c1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	44409761	75513	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	9	3	7	4.4	CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204880	75513	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	9	3	7	4.4	CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11846625	77531	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	498	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL209394	77531	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	498	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	122178610	120833	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581043	120833	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	46880461	6158	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	439	4	1	3	4.4	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)CC3)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081483	6158	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	439	4	1	3	4.4	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)CC3)cc2)c1	10.1016/j.bmcl.2010.01.043
	71453391	81434	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.2	CN(C)[C@@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	CHEMBL2164503	81434	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.2	CN(C)[C@@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	1221269	121520	12	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359530	121520	12	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44389151	62176	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	445	6	1	4	5.7	CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	CHEMBL178138	62176	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	445	6	1	4	5.7	CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	71451564	81500	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2	10.1016/j.bmc.2012.07.018
	CHEMBL2164834	81500	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2	10.1016/j.bmc.2012.07.018
	71449753	81490	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	465	4	2	3	4.7	CC1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164825	81490	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	465	4	2	3	4.7	CC1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	44409871	75046	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	426	7	3	8	2.4	CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203948	75046	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	426	7	3	8	2.4	CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46880569	6112	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081212	6112	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	70693640	72850	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL2011822	72850	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL449590	212212	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1074/jbc.m609796200
	44576247	212451	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Inverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212451	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Inverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	145994299	166842	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	523	5	1	4	6.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4295212	166842	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	523	5	1	4	6.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	71460577	81494	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	500	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)c(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164829	81494	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	500	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)c(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	16113902	137151	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL375859	137151	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	71462274	81437	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	528	5	2	4	3.8	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1=O	10.1016/j.bmc.2012.07.018
	CHEMBL2164506	81437	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	528	5	2	4	3.8	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1=O	10.1016/j.bmc.2012.07.018
	CHEMBL509976	213804	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	70683143	72849	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	574	8	2	5	5.3	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(Cl)cc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011821	72849	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	574	8	2	5	5.3	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(Cl)cc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	46880495	6292	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@@H]3C)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082162	6292	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@@H]3C)cc2)c1	10.1016/j.bmcl.2010.01.043
	11697618	62270	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	427	6	1	4	5.5	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178289	62270	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	427	6	1	4	5.5	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	145988557	166707	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	523	4	1	2	6.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4292914	166707	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	523	4	1	2	6.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	44409771	140722	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	461	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CC4C=CC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383073	140722	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	461	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CC4C=CC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145980333	166028	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	577	6	1	4	7.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4280040	166028	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	577	6	1	4	7.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	11329138	64129	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at GHSR expressed in CHOK cells assessed as inhibition of ghrelin-induced increase in intracellular calcium levelAntagonist activity at GHSR expressed in CHOK cells assessed as inhibition of ghrelin-induced increase in intracellular calcium level	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1021/jm0491750
	CHEMBL181350	64129	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at GHSR expressed in CHOK cells assessed as inhibition of ghrelin-induced increase in intracellular calcium levelAntagonist activity at GHSR expressed in CHOK cells assessed as inhibition of ghrelin-induced increase in intracellular calcium level	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1021/jm0491750
	44576247	212451	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212451	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	11568561	168987	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	447	7	1	5	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL443560	168987	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	447	7	1	5	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1	10.1016/j.bmcl.2004.11.075
	145991945	166262	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	4	7.8	CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4284715	166262	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	4	7.8	CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1	10.1021/acs.jmedchem.8b00794
	44394982	65807	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cellsAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells	ChEMBL	523	9	1	6	5.7	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL184093	65807	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cellsAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells	ChEMBL	523	9	1	6	5.7	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1	10.1016/j.bmcl.2004.06.060
	66788278	124672	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645254	124672	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942099	124674	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645256	124674	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942243	124676	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645258	124676	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	127045858	139332	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799225	139332	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	70681018	72847	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.0	Cc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL2011819	72847	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.0	Cc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	70685225	72881	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	576	8	2	5	5.0	CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011894	72881	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	576	8	2	5	5.0	CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	11410373	138006	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	558	10	4	8	4.2	Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1	10.1016/j.bmcl.2006.01.012
	CHEMBL377514	138006	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	558	10	4	8	4.2	Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1	10.1016/j.bmcl.2006.01.012
	11339816	75654	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	446	8	3	7	4.7	Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205521	75654	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	446	8	3	7	4.7	Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	145992253	166375	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	595	6	1	6	6.4	COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4286849	166375	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	595	6	1	6	6.4	COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11503585	64873	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	461	9	2	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL182542	64873	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	461	9	2	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1	10.1016/j.bmcl.2004.06.060
	44409762	75533	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	441	9	4	8	2.7	CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204884	75533	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	441	9	4	8	2.7	CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122180026	121073	0	None	8	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity against ghrelin receptor (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin-induced calcium responseAntagonist activity against ghrelin receptor (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin-induced calcium response	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586032	121073	0	None	8	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity against ghrelin receptor (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin-induced calcium responseAntagonist activity against ghrelin receptor (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin-induced calcium response	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	46880846	7531	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	3	4.4	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1088038	7531	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	3	4.4	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	44389248	121654	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	433	7	2	5	5.0	CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359714	121654	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	433	7	2	5	5.0	CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	70695749	72863	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	562	9	2	6	4.3	CC(C)[C@H](C(=O)N1CCC(NCCC2CCOCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011836	72863	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	562	9	2	6	4.3	CC(C)[C@H](C(=O)N1CCC(NCCC2CCOCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	122178614	120837	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581047	120837	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	70695748	72855	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	498	7	2	5	3.7	O=C1CN(CC(=O)NC2CCN(Cc3ccccc3)CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011827	72855	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	498	7	2	5	3.7	O=C1CN(CC(=O)NC2CCN(Cc3ccccc3)CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1	10.1016/j.bmcl.2012.01.014
	145981687	166024	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	509	5	1	3	6.5	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4279987	166024	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	509	5	1	3	6.5	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11508639	76182	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	CHEMBL206091	76182	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	44409683	75906	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	480	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205848	75906	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	480	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11626181	123862	1	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	431	7	1	4	6.3	CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363896	123862	1	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	431	7	1	4	6.3	CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	11690097	76319	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	411	6	2	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL206446	76319	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	411	6	2	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	44409775	75672	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	8	3	7	3.7	CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205605	75672	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	8	3	7	3.7	CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44576247	212451	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212451	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	11655355	74072	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL202642	74072	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	127047654	139447	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799883	139447	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	16113799	168148	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL436849	168148	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	145986080	165899	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	489	5	1	3	6.2	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4277793	165899	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	489	5	1	3	6.2	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	56942385	124678	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645260	124678	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	46880771	5833	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	448	3	1	4	4.4	C[C@H]1CN(C(=O)c2csc(-c3ccccc3F)n2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1079623	5833	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	448	3	1	4	4.4	C[C@H]1CN(C(=O)c2csc(-c3ccccc3F)n2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11654867	75848	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	429	7	3	5	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205833	75848	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	429	7	3	5	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1	10.1021/jm0510934
	122178600	120822	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581033	120822	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	46880844	7515	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	432	3	1	4	3.0	C[C@H]1CN(C(=O)c2ccc(N3CCOCC3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1087907	7515	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	432	3	1	4	3.0	C[C@H]1CN(C(=O)c2ccc(N3CCOCC3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11248021	138725	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	454	8	4	6	4.3	Nc1nc(N)c(-c2ccc(NC(=O)NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL378989	138725	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	454	8	4	6	4.3	Nc1nc(N)c(-c2ccc(NC(=O)NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	122182189	121494	0	None	-7	2	Rat	7.5	pIC50	=	7.5	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593814	121494	0	None	-7	2	Rat	7.5	pIC50	=	7.5	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	44409865	140187	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	500	7	3	8	3.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3Cc4ccccc4C3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL381759	140187	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	500	7	3	8	3.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3Cc4ccccc4C3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11751384	140974	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	453	9	3	6	4.6	Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL384524	140974	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	453	9	3	6	4.6	Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	44409679	75157	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	466	8	4	8	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204322	75157	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	466	8	4	8	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409868	76389	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	487	9	3	7	4.9	CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206673	76389	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	487	9	3	7	4.9	CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409667	75616	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	451	6	3	7	4.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205294	75616	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	451	6	3	7	4.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44576247	212451	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212451	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	56942388	139413	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799687	139413	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	11166495	75199	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	437	8	2	7	4.5	N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL204474	75199	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	437	8	2	7	4.5	N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	145994050	166791	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	6	7.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4294493	166791	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	6	7.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	11538533	74651	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203280	74651	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46880770	5832	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	458	3	1	3	4.9	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cn2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1079622	5832	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	458	3	1	3	4.9	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cn2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	71453390	81431	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	526	6	2	4	4.4	C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164500	81431	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	526	6	2	4	4.4	C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	44409763	140833	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	487	6	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3Cc4ccccc4O3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383757	140833	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	487	6	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3Cc4ccccc4O3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409989	165273	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	467	11	3	7	4.8	CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL424860	165273	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	467	11	3	7	4.8	CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44410008	140720	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	9	2	7	4.2	CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383058	140720	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	9	2	7	4.2	CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11178309	79491	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	445	8	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL212415	79491	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	445	8	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	11517629	167775	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	431	6	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL434330	167775	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	431	6	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1	10.1016/j.bmcl.2004.11.075
	127047655	139084	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797531	139084	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127046957	139177	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798155	139177	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	127045858	139332	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799225	139332	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	56942098	124673	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645255	124673	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127046957	139177	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798155	139177	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	46880630	6021	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	491	3	1	2	5.8	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3C(F)(F)F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080735	6021	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	491	3	1	2	5.8	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3C(F)(F)F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	70685219	72862	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	560	9	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(NCCC2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011835	72862	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	560	9	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(NCCC2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	16113245	120820	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581030	120820	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	122178607	120830	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581040	120830	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	11452801	138768	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	417	7	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL379191	138768	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	417	7	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	46882763	5552	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-stimulated intracellular calcium mobilizationAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-stimulated intracellular calcium mobilization	ChEMBL	612	17	6	7	5.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1077617	5552	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-stimulated intracellular calcium mobilizationAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-stimulated intracellular calcium mobilization	ChEMBL	612	17	6	7	5.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44409776	76790	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	7	3	7	3.5	CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207754	76790	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	7	3	7	3.5	CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145991797	166363	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	613	5	1	6	6.5	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)NCc4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4286597	166363	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	613	5	1	6	6.5	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)NCc4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	122178616	120838	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581048	120838	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	11430583	79807	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	439	8	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL213704	79807	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	439	8	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL509976	213804	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	11669486	64283	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	445	7	1	4	6.6	CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	CHEMBL181736	64283	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	445	7	1	4	6.6	CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	44409946	139285	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	514	7	3	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc4C3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL379887	139285	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	514	7	3	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc4C3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	127046806	139403	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799604	139403	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	122178600	120822	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581033	120822	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	11605333	76372	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	475	6	3	7	3.6	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1	10.1021/jm0510934
	CHEMBL206589	76372	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	475	6	3	7	3.6	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1	10.1021/jm0510934
	46880845	7530	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	460	3	1	3	4.5	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1088037	7530	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	460	3	1	3	4.5	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	46880773	6130	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccccn3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081301	6130	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccccn3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178604	120826	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581037	120826	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	56942387	139132	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797857	139132	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	44576247	212451	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212451	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	11683469	76353	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	433	6	3	7	3.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1	10.1021/jm0510934
	CHEMBL206486	76353	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	433	6	3	7	3.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1	10.1021/jm0510934
	44389216	123336	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	442	6	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL362595	123336	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	442	6	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1	10.1016/j.bmcl.2004.11.075
	145979819	165920	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	655	8	1	6	7.9	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4278185	165920	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	655	8	1	6	7.9	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	46880498	5918	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	507	4	1	3	5.7	C[C@H]1CN(C(=O)c2ccc(-c3cccc(OC(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080155	5918	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	507	4	1	3	5.7	C[C@H]1CN(C(=O)c2ccc(-c3cccc(OC(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	71462273	81436	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	513	5	2	3	5.7	CCN1CCCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	CHEMBL2164505	81436	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	513	5	2	3	5.7	CCN1CCCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	71453404	81491	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164826	81491	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	44389283	62616	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	403	5	1	4	5.7	CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178494	62616	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	403	5	1	4	5.7	CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	11179347	77000	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	490	9	2	8	4.0	CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL208477	77000	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	490	9	2	8	4.0	CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	44409764	76796	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	488	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207792	76796	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	488	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11606121	64245	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	523	6	2	6	5.9	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.11.075
	CHEMBL181584	64245	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	523	6	2	6	5.9	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.11.075
	11539587	66742	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	445	8	1	4	6.7	CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL187271	66742	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	445	8	1	4	6.7	CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL3586019	210054	4	None	-	1	Rat	8.3	pIC50	=	8.3	Functional	Inverse agonist activity at rat ghrelin receptor by inositol phosphate turnover assayInverse agonist activity at rat ghrelin receptor by inositol phosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1016/j.bmcl.2015.04.040
	122178608	120831	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581041	120831	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	44409821	75684	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	564	10	4	8	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205711	75684	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	564	10	4	8	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11340044	140804	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL383522	140804	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	70683149	72876	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	504	8	2	5	3.9	CC(C)[C@H](C(=O)N1CCC(NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011887	72876	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	504	8	2	5	3.9	CC(C)[C@H](C(=O)N1CCC(NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	71452183	83116	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at ghrelin receptor assessed as inhibition of ghrelin-induced Ca2+ release by cell based assayAntagonist activity at ghrelin receptor assessed as inhibition of ghrelin-induced Ca2+ release by cell based assay	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	10.1021/jm1012374
	CHEMBL2203623	83116	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at ghrelin receptor assessed as inhibition of ghrelin-induced Ca2+ release by cell based assayAntagonist activity at ghrelin receptor assessed as inhibition of ghrelin-induced Ca2+ release by cell based assay	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	10.1021/jm1012374
	122178602	120824	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581035	120824	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	11582836	62584	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	431	7	1	4	6.4	CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178463	62584	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	431	7	1	4	6.4	CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44389192	168081	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	471	4	1	4	6.2	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1	10.1016/j.bmcl.2004.11.075
	CHEMBL436275	168081	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	471	4	1	4	6.2	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1	10.1016/j.bmcl.2004.11.075
	71455106	81501	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	442	5	2	5	2.2	COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(C)cc32)cc1	10.1016/j.bmc.2012.07.018
	CHEMBL2164835	81501	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	442	5	2	5	2.2	COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(C)cc32)cc1	10.1016/j.bmc.2012.07.018
	44409998	138007	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	413	7	3	8	2.5	COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL377515	138007	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	413	7	3	8	2.5	COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145984632	165838	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	629	5	1	4	8.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4276775	165838	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	629	5	1	4	8.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1	10.1021/acs.jmedchem.8b00794
	10415364	126246	0	None	-5	3	Human	7.3	pIC50	=	7.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL365294	126246	0	None	-5	3	Human	7.3	pIC50	=	7.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	15949382	74499	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	6	3	8	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CCCO3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203158	74499	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	6	3	8	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CCCO3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145993313	166339	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	577	7	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4286101	166339	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	577	7	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	11605822	123869	1	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	503	9	1	6	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363930	123869	1	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	503	9	1	6	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1	10.1016/j.bmcl.2004.06.060
	11154001	79478	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	406	7	4	6	3.6	CC(C)NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL212354	79478	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	406	7	4	6	3.6	CC(C)NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	44394930	66000	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185028	66000	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1	10.1016/j.bmcl.2004.06.060
	11699004	65871	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	501	9	1	5	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL184429	65871	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	501	9	1	5	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1	10.1016/j.bmcl.2004.06.060
	11618705	166385	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	423	6	1	4	5.3	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL428698	166385	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	423	6	1	4	5.3	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1	10.1016/j.bmcl.2004.06.060
	44409785	75450	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	6	3	8	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CCCO3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204852	75450	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	6	3	8	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CCCO3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409990	76164	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	481	12	3	7	5.2	CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205995	76164	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	481	12	3	7	5.2	CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145992125	166197	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	552	5	2	5	6.2	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4283504	166197	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	552	5	2	5	6.2	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	46880568	6311	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	423	3	1	2	4.8	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082211	6311	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	423	3	1	2	4.8	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	70687383	72877	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	525	9	2	4	6.6	CC(C)[C@H](C[C@H]1CC[C@@H](NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011890	72877	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	525	9	2	4	6.6	CC(C)[C@H](C[C@H]1CC[C@@H](NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	16113245	120820	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581030	120820	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL509976	213804	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	57422817	112950	13	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	620	8	2	10	3.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	CHEMBL3319223	112950	13	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	620	8	2	10	3.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	11190594	75632	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	469	10	3	8	3.9	CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205445	75632	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	469	10	3	8	3.9	CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	56942385	124678	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645260	124678	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	44576247	212451	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212451	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	16113904	136512	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL374655	136512	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	44389215	62749	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178838	62749	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44576247	212451	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212451	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	44409809	74715	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	10	3	7	4.4	CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203578	74715	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	10	3	7	4.4	CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16113468	141268	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL386218	141268	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	11531313	62175	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	394	7	1	6	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178137	62175	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	394	7	1	6	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44389167	123340	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	425	7	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL362612	123340	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	425	7	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	46880674	6065	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccc(F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080926	6065	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccc(F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	71455085	81432	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	4	2	4	4.3	CN1CCCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164501	81432	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	4	2	4	4.3	CN1CCCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	46880463	6191	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@H](C)C3)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081649	6191	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@H](C)C3)cc2)c1	10.1016/j.bmcl.2010.01.043
	46880812	5944	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	430	3	1	4	4.3	C[C@H]1CN(C(=O)c2ccc(-c3cncs3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080320	5944	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	430	3	1	4	4.3	C[C@H]1CN(C(=O)c2ccc(-c3cncs3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	46880497	6294	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	423	3	1	2	4.8	O=C(c1ccc(-c2ccccc2)cc1)N1CCCN(C(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082164	6294	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	423	3	1	2	4.8	O=C(c1ccc(-c2ccccc2)cc1)N1CCCN(C(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/j.bmcl.2010.01.043
	44409770	140836	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	461	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CC4C=CC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383766	140836	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	461	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CC4C=CC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122178604	120826	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581037	120826	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	46880496	6293	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@H]3C)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082163	6293	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@H]3C)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL502208	212379	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1074/jbc.m609796200
	145980382	166090	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4281310	166090	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44389186	64284	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	379	7	1	5	4.8	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL181739	64284	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	379	7	1	5	4.8	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44409864	75148	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	502	9	3	8	4.0	CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204266	75148	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	502	9	3	8	4.0	CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409975	75438	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	411	7	3	7	3.3	CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204835	75438	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	411	7	3	7	3.3	CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409455	75615	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	487	6	3	7	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1	10.1021/jm0510934
	CHEMBL205286	75615	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	487	6	3	7	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1	10.1021/jm0510934
	11441554	218	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	10.1021/jm060461g
	5871	218	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	10.1021/jm060461g
	CHEMBL212761	218	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	10.1021/jm060461g
	11340329	79192	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	468	9	4	6	4.4	Nc1nc(N)c(-c2ccc(NC(=O)NCCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL211454	79192	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	468	9	4	6	4.4	Nc1nc(N)c(-c2ccc(NC(=O)NCCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	122178605	120827	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581038	120827	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	127047655	139084	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797531	139084	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	46880672	6119	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1ccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)cc1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081254	6119	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1ccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)cc1	10.1016/j.bmcl.2010.01.043
	66601728	81429	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164499	81429	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	70689440	72846	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.0	Cc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011818	72846	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.0	Cc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1	10.1016/j.bmcl.2012.01.014
	70693644	72880	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	496	9	1	3	6.7	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011893	72880	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	496	9	1	3	6.7	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	70695747	72844	0	None	1	2	Mouse	8.2	pIC50	=	8.2	Functional	Antagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011816	72844	0	None	1	2	Mouse	8.2	pIC50	=	8.2	Functional	Antagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	11225576	165484	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL425594	165484	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11225576	165484	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL425594	165484	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	122178608	120831	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581041	120831	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	122178609	120832	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581042	120832	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	56942388	139413	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799687	139413	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942535	139231	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798525	139231	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	11176805	76981	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	391	7	3	6	4.5	CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm0510934
	CHEMBL208374	76981	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	391	7	3	6	4.5	CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm0510934
	71453405	81499	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	462	5	2	5	2.6	COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(Cl)cc32)cc1	10.1016/j.bmc.2012.07.018
	CHEMBL2164833	81499	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	462	5	2	5	2.6	COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(Cl)cc32)cc1	10.1016/j.bmc.2012.07.018
	44394913	126652	1	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	537	10	1	5	7.5	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccccc2OC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL365721	126652	1	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	537	10	1	5	7.5	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccccc2OC)cc1	10.1016/j.bmcl.2004.06.060
	44409832	76057	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	398	6	4	8	1.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205955	76057	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	398	6	4	8	1.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN)cc2)cc1	10.1016/j.bmcl.2006.01.012
	25190383	81497	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164831	81497	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	122178615	120790	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3580668	120790	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	44410013	76700	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	10	3	7	4.5	CCCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207268	76700	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	10	3	7	4.5	CCCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44389243	64252	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	557	7	1	6	6.2	O=C(Nc1ccccc1C(=O)N1CCCCC1)c1c(-c2c(Cl)cccc2Cl)noc1CCC1OCCCO1	10.1016/j.bmcl.2004.11.075
	CHEMBL181619	64252	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	557	7	1	6	6.2	O=C(Nc1ccccc1C(=O)N1CCCCC1)c1c(-c2c(Cl)cccc2Cl)noc1CCC1OCCCO1	10.1016/j.bmcl.2004.11.075
	753168	122723	33	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	349	6	1	4	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL361366	122723	33	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	349	6	1	4	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	46880566	6309	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	491	3	1	2	5.8	C[C@H]1CN(C(=O)c2ccc(-c3cccc(C(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082209	6309	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	491	3	1	2	5.8	C[C@H]1CN(C(=O)c2ccc(-c3cccc(C(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178603	120825	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581036	120825	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	44409979	140029	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	7	2	7	3.4	CCc1nc(N)nc(N(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL381159	140029	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	7	2	7	3.4	CCc1nc(N)nc(N(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11256439	75029	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	344	5	3	6	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C#N)cc2)cc1	10.1021/jm0510934
	CHEMBL203843	75029	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	344	5	3	6	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C#N)cc2)cc1	10.1021/jm0510934
	11655578	169466	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	462	8	3	7	5.2	Nc1nc(N)c(-c2ccc(NCc3cnc4ccccc4c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL444277	169466	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	462	8	3	7	5.2	Nc1nc(N)c(-c2ccc(NCc3cnc4ccccc4c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	70681019	72852	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011824	72852	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1	10.1016/j.bmcl.2012.01.014
	122178612	120835	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581045	120835	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	11617435	75644	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	359	5	3	6	4.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2csc(Cl)c2)cc1	10.1021/jm0510934
	CHEMBL205486	75644	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	359	5	3	6	4.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2csc(Cl)c2)cc1	10.1021/jm0510934
	145988647	166519	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4289530	166519	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11663710	123948	1	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363995	123948	1	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	56942099	124674	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645256	124674	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942242	124675	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645257	124675	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	11663710	123948	1	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationAntagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilization	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2012.01.014
	CHEMBL363995	123948	1	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationAntagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilization	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2012.01.014
	70695747	72844	0	None	-1	2	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011816	72844	0	None	-1	2	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	70687380	72858	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011831	72858	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	122178605	120827	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581038	120827	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	145988894	166591	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4290680	166591	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	16203569	141201	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL385803	141201	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	145981343	166156	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	669	6	1	6	7.6	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4282719	166156	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	669	6	1	6	7.6	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL509976	213804	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Agonist activity at human ghrelin receptor Phe7:06Leu(Phe306) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Phe7:06Leu(Phe306) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	122178615	120790	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3580668	120790	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	44409810	140369	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	469	9	3	9	2.8	CCOC(=O)CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL382138	140369	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	469	9	3	9	2.8	CCOC(=O)CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16113124	120821	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccncc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581032	120821	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccncc2)cc1	10.1016/j.bmcl.2014.11.031
	44576247	212451	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212451	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	44409536	75158	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	579	9	3	8	5.2	Nc1nc(N)c(-c2ccc(NCc3cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL204325	75158	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	579	9	3	8	5.2	Nc1nc(N)c(-c2ccc(NCc3cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	145992835	166281	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4285075	166281	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11327400	75022	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	412	8	3	7	4.0	Nc1nc(N)c(-c2ccc(NCc3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL203782	75022	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	412	8	3	7	4.0	Nc1nc(N)c(-c2ccc(NCc3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	11539588	66579	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	445	7	1	4	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C(C)C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL186540	66579	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	445	7	1	4	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C(C)C)cc1	10.1016/j.bmcl.2004.06.060
	16113796	84258	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL222518	84258	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	11442040	78141	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	440	7	4	6	4.7	Nc1nc(N)c(-c2ccc(NC(=O)Nc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL211211	78141	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	440	7	4	6	4.7	Nc1nc(N)c(-c2ccc(NC(=O)Nc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	122178601	120823	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581034	120823	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	56942243	124676	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645258	124676	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	46880725	6182	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	455	3	1	2	5.3	Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1F	10.1016/j.bmcl.2010.01.043
	CHEMBL1081612	6182	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	455	3	1	2	5.3	Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1F	10.1016/j.bmcl.2010.01.043
	122178609	120832	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581042	120832	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	11454617	140788	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	488	8	3	8	4.0	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383411	140788	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	488	8	3	8	4.0	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2006.01.012
	46880628	5955	0	None	-4	2	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080389	5955	0	None	-4	2	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	44409684	140354	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	474	8	4	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL382033	140354	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	474	8	4	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409672	139957	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	479	9	3	9	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccco3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL380971	139957	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	479	9	3	9	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccco3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409673	76397	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	493	9	3	9	3.9	Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)o1	10.1016/j.bmcl.2006.01.012
	CHEMBL206741	76397	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	493	9	3	9	3.9	Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)o1	10.1016/j.bmcl.2006.01.012
	11453509	75825	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	441	9	3	7	4.6	COc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205784	75825	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	441	9	3	7	4.6	COc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	127047362	139189	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798204	139189	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	56942535	139231	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798525	139231	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	145990956	166468	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	509	4	1	2	6.6	C[C@H](NC(=O)N(C)C1CCN(C2CCc3ccccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4288441	166468	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	509	4	1	2	6.6	C[C@H](NC(=O)N(C)C1CCN(C2CCc3ccccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44394947	168657	1	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL440939	168657	1	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)cc1	10.1016/j.bmcl.2004.06.060
	44410007	76074	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	438	8	4	8	2.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205963	76074	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	438	8	4	8	2.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11583811	75634	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	479	8	3	6	5.7	Nc1nc(N)c(-c2ccc(NCc3ccc(C(F)(F)F)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205450	75634	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	479	8	3	6	5.7	Nc1nc(N)c(-c2ccc(NCc3ccc(C(F)(F)F)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	11576960	66779	1	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	500	8	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL187427	66779	1	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	500	8	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	11281346	75665	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	411	8	3	6	4.6	Nc1nc(N)c(-c2ccc(NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205568	75665	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	411	8	3	6	4.6	Nc1nc(N)c(-c2ccc(NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL499371	212324	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O	10.1074/jbc.m609796200
	155540883	172388	0	None	-	1	Human	8.8	pKd	=	8.8	Functional	Competitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assayCompetitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172388	0	None	-	1	Human	8.8	pKd	=	8.8	Functional	Competitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assayCompetitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	155540883	172388	0	None	-	1	Human	8.0	pKd	=	8.0	Functional	Competitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assayCompetitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172388	0	None	-	1	Human	8.0	pKd	=	8.0	Functional	Competitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assayCompetitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	155557019	174015	0	None	-	1	Human	7.5	pKd	=	7.5	Functional	Competitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assayCompetitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174015	0	None	-	1	Human	7.5	pKd	=	7.5	Functional	Competitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assayCompetitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	155557019	174015	0	None	-	1	Human	7.1	pKd	=	7.1	Functional	Competitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assayCompetitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174015	0	None	-	1	Human	7.1	pKd	=	7.1	Functional	Competitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assayCompetitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	57399248	68702	0	None	-	1	Human	9.0	pKi	=	9	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	CHEMBL1923617	68702	0	None	-	1	Human	9.0	pKi	=	9	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	71452183	83116	0	None	-	1	Human	7.0	pKi	=	7	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	10.1021/jm1012374
	CHEMBL2203623	83116	0	None	-	1	Human	7.0	pKi	=	7	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	10.1021/jm1012374
	44454117	155016	0	None	-	1	Human	7.9	pKi	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL404336	155016	0	None	-	1	Human	7.9	pKi	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	44454060	154793	0	None	-	1	Human	5.9	pKi	=	5.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL403180	154793	0	None	-	1	Human	5.9	pKi	=	5.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454367	94817	0	None	-	1	Human	7.8	pKi	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	CHEMBL256235	94817	0	None	-	1	Human	7.8	pKi	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	44454338	97386	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL272085	97386	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	44434080	89481	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL237933	89481	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454302	158833	0	None	-	1	Human	6.6	pKi	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	CHEMBL410060	158833	0	None	-	1	Human	6.6	pKi	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	44454092	97200	0	None	-	1	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL271082	97200	0	None	-	1	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	44454432	154719	0	None	-	1	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL402808	154719	0	None	-	1	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	9950632	88278	0	None	-	1	Human	5.5	pKi	=	5.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL236038	88278	0	None	-	1	Human	5.5	pKi	=	5.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.01.100
	44454399	154600	0	None	-	1	Human	6.5	pKi	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL402086	154600	0	None	-	1	Human	6.5	pKi	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454432	154719	0	None	-	1	Human	5.4	pKi	=	5.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL402808	154719	0	None	-	1	Human	5.4	pKi	=	5.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	25022640	97352	0	None	-	1	Human	7.4	pKi	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	CHEMBL271876	97352	0	None	-	1	Human	7.4	pKi	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	44454092	97200	0	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL271082	97200	0	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	44454303	97120	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	CHEMBL270666	97120	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	44454304	97154	0	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	CHEMBL270876	97154	0	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	56926461	68694	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	CHEMBL1923609	68694	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	44454398	97149	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL270851	97149	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1	10.1016/j.bmcl.2008.01.100
	44454060	154793	0	None	-	1	Human	7.2	pKi	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL403180	154793	0	None	-	1	Human	7.2	pKi	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454367	94817	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	CHEMBL256235	94817	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	44454337	155063	0	None	-	1	Human	8.1	pKi	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL404545	155063	0	None	-	1	Human	8.1	pKi	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454117	155016	0	None	-	1	Human	6.1	pKi	=	6.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL404336	155016	0	None	-	1	Human	6.1	pKi	=	6.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	1099	1757	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Measuring ghrelin-induced GHSR activation detected by β-arrestin recruitment in cells stably expressing hGHSR.Measuring ghrelin-induced GHSR activation detected by β-arrestin recruitment in cells stably expressing hGHSR.	Guide to Pharmacology		None	None	None		None	29233536
	121879	2204	19	None	-3	5	Human	7.0	pEC50	=	7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	5868	2204	19	None	-3	5	Human	7.0	pEC50	=	7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	CHEMBL308716	2204	19	None	-3	5	Human	7.0	pEC50	=	7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	5869	4017	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	21402696
	121879	2204	19	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	8503009
	5868	2204	19	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	8503009
	CHEMBL308716	2204	19	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	8503009
	1099	1757	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10628755
	1099	1757	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	121879	2204	19	None	-3	5	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	5868	2204	19	None	-3	5	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	CHEMBL308716	2204	19	None	-3	5	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	1093	1764	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	4345065	1764	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	1093	1764	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	4345065	1764	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	178024	1940	30	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	178024	1940	30	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	15905359
	5867	1940	30	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	5867	1940	30	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	15905359
	CHEMBL13817	1940	30	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	CHEMBL13817	1940	30	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	15905359
	1099	1757	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12907757
	1099	1757	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	21402696
	5866	3567	3	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	18923064
	9804743	3567	3	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	18923064
	CHEMBL360227	3567	3	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	18923064
	9734	2299	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	IC<sub>50</sub> for LEAP2 antagonism of GHSR activation in the presence of ghrelin.IC<sub>50</sub> for LEAP2 antagonism of GHSR activation in the presence of ghrelin.	Guide to Pharmacology		None	None	None		None	29233536
	11441554	218	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	16854051
	5871	218	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	16854051
	CHEMBL212761	218	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	16854051
	5872	2093	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	603	10	3	8	5.4	COc1ccc(c(c1)OC)n1c(nnc1n1cc(c2c1cccc2)CC)[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H]1CCCN1	17927165
	74015851	2093	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	603	10	3	8	5.4	COc1ccc(c(c1)OC)n1c(nnc1n1cc(c2c1cccc2)CC)[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H]1CCCN1	17927165
	25124566	1844	6	None	2	2	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	20593439
	5870	1844	6	None	2	2	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	20593439
	CHEMBL3358452	1844	6	None	2	2	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	20593439
	5866	3567	3	None	-	1	Human	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	11741481
	9804743	3567	3	None	-	1	Human	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	11741481
	CHEMBL360227	3567	3	None	-	1	Human	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	11741481
	25124566	1844	6	None	-2	2	Rat	8.0	pKB	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	21034740
	5870	1844	6	None	-2	2	Rat	8.0	pKB	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	21034740
	CHEMBL3358452	1844	6	None	-2	2	Rat	8.0	pKB	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	21034740

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	178024	1940	30	None	-	1	Human	9.7	pEC50	=	9.7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm301653f
	5867	1940	30	None	-	1	Human	9.7	pEC50	=	9.7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm301653f
	CHEMBL13817	1940	30	None	-	1	Human	9.7	pEC50	=	9.7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm301653f
	22867441	10218	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161835	10218	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	67457995	91401	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@H](O)c1ccccc12	10.1016/j.bmc.2013.06.006
	CHEMBL2413152	91401	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@H](O)c1ccccc12	10.1016/j.bmc.2013.06.006
	22867441	10218	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161835	10218	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	71716660	85575	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	5	5	2.7	CCNC(O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	CHEMBL2304221	85575	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	5	5	2.7	CCNC(O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	10345516	138745	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1021/jm058053k
	CHEMBL379074	138745	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1021/jm058053k
	71716660	85575	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	5	5	2.7	CCNC(O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	CHEMBL2304221	85575	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	5	5	2.7	CCNC(O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	10345516	138745	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1021/jm058053k
	CHEMBL379074	138745	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1021/jm058053k
	9807597	182435	3	None	-	0	Human	9.0	pEC50	=	9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	513	7	4	4	3.5	CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
	CHEMBL47938	182435	3	None	-	0	Human	9.0	pEC50	=	9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	513	7	4	4	3.5	CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
	10323604	10212	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161828	10212	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	10323604	10212	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161828	10212	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	44411920	77525	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	3	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	CHEMBL209360	77525	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	3	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	162662316	180941	0	None	-	0	Rat	8.9	pEC50	=	8.9	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	542	8	3	6	2.6	CC(C)(N)NC(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CC(S(C)(=O)=O)c1ccccc12	10.1021/acs.jmedchem.0c00829
	CHEMBL4765101	180941	0	None	-	0	Rat	8.9	pEC50	=	8.9	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	542	8	3	6	2.6	CC(C)(N)NC(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CC(S(C)(=O)=O)c1ccccc12	10.1021/acs.jmedchem.0c00829
	90666017	108812	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Agonist activity at GSH-R1a in human U2OS cells after 2 hrs by FLIPR assayAgonist activity at GSH-R1a in human U2OS cells after 2 hrs by FLIPR assay	ChEMBL	472	6	0	8	4.1	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218890	108812	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Agonist activity at GSH-R1a in human U2OS cells after 2 hrs by FLIPR assayAgonist activity at GSH-R1a in human U2OS cells after 2 hrs by FLIPR assay	ChEMBL	472	6	0	8	4.1	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	44411920	77525	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	3	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	CHEMBL209360	77525	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	3	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	10625750	167591	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	CHEMBL433087	167591	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	10625750	167591	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	CHEMBL433087	167591	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	10626337	100755	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1021/jm058053k
	CHEMBL295984	100755	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1021/jm058053k
	44411718	10209	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	467	7	2	5	3.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	CHEMBL1161825	10209	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	467	7	2	5	3.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	44293557	100619	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL294923	100619	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL540001	100619	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	16040587	178804	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm301653f
	CHEMBL473921	178804	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm301653f
	16040587	178804	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Inhibition of human Ghrelin receptorInhibition of human Ghrelin receptor	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL473921	178804	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Inhibition of human Ghrelin receptorInhibition of human Ghrelin receptor	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	16752689	187784	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1021/jm301653f
	CHEMBL501315	187784	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1021/jm301653f
	9890375	97818	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL274599	97818	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL558802	97818	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	9890375	97818	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL274599	97818	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL558802	97818	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	10026738	162219	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL417182	162219	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL557206	162219	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	10026738	162219	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL417182	162219	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL557206	162219	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	10745533	139590	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL380096	139590	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	10745533	139590	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL380096	139590	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	44411745	10211	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	CHEMBL1161827	10211	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	10626337	100755	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1021/jm058053k
	CHEMBL295984	100755	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1021/jm058053k
	44411634	10208	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161824	10208	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	44411634	10208	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161824	10208	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	44411745	10211	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	CHEMBL1161827	10211	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	44411753	10213	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	CHEMBL1161829	10213	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	44411753	10213	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	CHEMBL1161829	10213	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	44293091	187603	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL49884	187603	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	44293091	187603	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL49884	187603	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	46905972	10311	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	471	10	1	3	4.8	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1	10.1021/jm058053k
	CHEMBL1162926	10311	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	471	10	1	3	4.8	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1	10.1021/jm058053k
	15481181	77391	2	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	CHEMBL209020	77391	2	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	9810101	98792	12	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL281764	98792	12	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	15481188	140679	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1021/jm058053k
	CHEMBL382844	140679	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1021/jm058053k
	CHEMBL1793862	207185	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL		None	None	None		CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm058053k
	216208	9635	27	None	-	1	Rat	8.5	pEC50	=	8.5	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.0c00829
	CHEMBL113313	9635	27	None	-	1	Rat	8.5	pEC50	=	8.5	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.0c00829
	46905972	10311	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	471	10	1	3	4.8	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1	10.1021/jm058053k
	CHEMBL1162926	10311	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	471	10	1	3	4.8	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1	10.1021/jm058053k
	15481181	77391	2	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	CHEMBL209020	77391	2	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	9810101	98792	12	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL281764	98792	12	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	15481188	140679	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1021/jm058053k
	CHEMBL382844	140679	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1021/jm058053k
	CHEMBL1793862	207185	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL		None	None	None		CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm058053k
	15481185	76908	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	CHEMBL207970	76908	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	15481185	76908	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	CHEMBL207970	76908	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	44411584	10206	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	CHEMBL1161822	10206	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	44411584	10206	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	CHEMBL1161822	10206	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	22862436	10217	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161834	10217	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	10602640	137661	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1021/jm058053k
	CHEMBL376970	137661	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1021/jm058053k
	10791616	139006	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL379564	139006	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	10029990	168718	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL441360	168718	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	22862436	10217	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161834	10217	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	10602640	137661	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1021/jm058053k
	CHEMBL376970	137661	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1021/jm058053k
	10791616	139006	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL379564	139006	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	10029990	168718	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL441360	168718	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	44411632	10207	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	CHEMBL1161823	10207	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	44411632	10207	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	CHEMBL1161823	10207	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	23529194	101721	0	None	-	0	Rat	7.3	pEC50	=	7.3	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	525	5	3	3	4.0	O=C(NC(Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1)NC1CN2CCC1CC2	10.1021/acs.jmedchem.0c00829
	CHEMBL302810	101721	0	None	-	0	Rat	7.3	pEC50	=	7.3	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	525	5	3	3	4.0	O=C(NC(Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1)NC1CN2CCC1CC2	10.1021/acs.jmedchem.0c00829
	16041292	183029	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Inhibition of human Ghrelin receptorInhibition of human Ghrelin receptor	ChEMBL	490	6	2	6	3.9	C[C@H]1CN(Cc2ccc(-n3ccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL480219	183029	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Inhibition of human Ghrelin receptorInhibition of human Ghrelin receptor	ChEMBL	490	6	2	6	3.9	C[C@H]1CN(Cc2ccc(-n3ccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	44411913	10216	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	CHEMBL1161833	10216	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	44411913	10216	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	CHEMBL1161833	10216	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	44411905	10215	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161832	10215	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	10506325	100771	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
	CHEMBL296104	100771	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
	44411905	10215	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161832	10215	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	10506325	100771	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
	CHEMBL296104	100771	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
	10600702	140805	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL383526	140805	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	10600702	140805	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL383526	140805	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL335799	209818	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1016/j.bmc.2013.06.006
	44411720	10210	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	CHEMBL1161826	10210	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	44411902	10214	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	CHEMBL1161831	10214	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	44411720	10210	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	CHEMBL1161826	10210	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	44411902	10214	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	CHEMBL1161831	10214	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	44390849	62586	0	None	-	0	Human	10.7	pIC50	=	10.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(Cl)cc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL178475	62586	0	None	-	0	Human	10.7	pIC50	=	10.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(Cl)cc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	25227441	112944	0	None	-	0	Human	10.1	pIC50	=	10.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	563	8	2	8	3.9	CCc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	CHEMBL3319217	112944	0	None	-	0	Human	10.1	pIC50	=	10.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	563	8	2	8	3.9	CCc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	CHEMBL501253	212362	0	None	-	0	Human	10.1	pIC50	=	10.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CCCCCCCBr)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm0001727
	44582528	192813	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3419	113	48	48	-14.7	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm0001727
	91935097	192813	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3419	113	48	48	-14.7	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm0001727
	CHEMBL525994	192813	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3419	113	48	48	-14.7	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm0001727
	CHEMBL2310891	207750	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
	90665845	108784	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	485	5	0	4	6.8	Cc1ccccc1-c1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL3218645	108784	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	485	5	0	4	6.8	Cc1ccccc1-c1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL500468	212344	0	None	-	1	Human	9.9	pIC50	=	9.9	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2005.02.042
	57422686	112948	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	600	8	2	9	4.1	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccc5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319221	112948	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	600	8	2	9	4.1	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccc5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL2310888	207748	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C	10.1021/jm0001727
	11340044	140804	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL383522	140804	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	44336274	108083	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Inhibitory concentration (biotinylated probe) is evaluated for [35S]- MK-0677 bindingInhibitory concentration (biotinylated probe) is evaluated for [35S]- MK-0677 binding	ChEMBL	896	22	6	10	2.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(=O)(=O)CC(=O)NCCCCCCNC(=O)CCCC[C@@H]1SCC3NC(=O)NC31)c1ccccc12	10.1021/jm970342o
	CHEMBL320289	108083	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Inhibitory concentration (biotinylated probe) is evaluated for [35S]- MK-0677 bindingInhibitory concentration (biotinylated probe) is evaluated for [35S]- MK-0677 binding	ChEMBL	896	22	6	10	2.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(=O)(=O)CC(=O)NCCCCCCNC(=O)CCCC[C@@H]1SCC3NC(=O)NC31)c1ccccc12	10.1021/jm970342o
	122180027	121074	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	566	8	2	7	5.2	CC(C)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586033	121074	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	566	8	2	7	5.2	CC(C)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	118709502	112973	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	629	8	2	10	3.8	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)c(C#N)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319398	112973	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	629	8	2	10	3.8	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)c(C#N)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	44390862	63536	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2cc(Cl)ccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL180349	63536	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2cc(Cl)ccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	16133832	211583	15	None	-	1	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
	CHEMBL425281	211583	15	None	-	1	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
	CHEMBL500468	212344	0	None	-	1	Human	9.6	pIC50	=	9.6	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/s0960-894x(01)00324-9
	90665847	108786	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	475	5	0	6	5.3	Cc1ccccc1-c1nc2cn(-c3ccc(Cl)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL3218647	108786	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	475	5	0	6	5.3	Cc1ccccc1-c1nc2cn(-c3ccc(Cl)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	122182190	121495	0	None	-	0	Rat	9.6	pIC50	=	9.6	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	CHEMBL3593815	121495	0	None	-	0	Rat	9.6	pIC50	=	9.6	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	57422687	112949	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	604	8	2	9	3.9	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319222	112949	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	604	8	2	9	3.9	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	16114292	96486	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL266063	96486	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	16114292	96486	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL266063	96486	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	11225576	165484	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL425594	165484	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	122182047	121488	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593636	121488	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	11225576	165484	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL425594	165484	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	25260749	112947	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	579	9	2	9	3.7	CCOc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	CHEMBL3319220	112947	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	579	9	2	9	3.7	CCOc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	57422792	112972	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	635	8	2	10	4.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)c(Cl)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319397	112972	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	635	8	2	10	4.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)c(Cl)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	57422692	112946	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	575	8	2	8	4.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(C5CC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319219	112946	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	575	8	2	8	4.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(C5CC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL500468	212344	0	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm020985q
	122182043	121484	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL3593632	121484	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	118709506	112983	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	586	5	2	9	4.3	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)c(C#N)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319407	112983	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	586	5	2	9	4.3	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)c(C#N)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	178024	1940	30	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm0309452
	5867	1940	30	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm0309452
	CHEMBL13817	1940	30	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm0309452
	11431274	76991	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	9	3	8	3.8	CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL208424	76991	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	9	3	8	3.8	CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11410373	138006	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	558	10	4	8	4.2	Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1	10.1016/j.bmcl.2006.01.012
	CHEMBL377514	138006	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	558	10	4	8	4.2	Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1	10.1016/j.bmcl.2006.01.012
	44582531	188136	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3368	117	49	47	-15.3	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
	91935100	188136	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3368	117	49	47	-15.3	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
	CHEMBL504776	188136	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3368	117	49	47	-15.3	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
	122182046	121487	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593635	121487	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
	25260745	112976	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	573	10	2	8	5.2	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccc4)ccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319400	112976	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	573	10	2	8	5.2	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccc4)ccc3Cl)sc2c1	10.1021/jm500610n
	122182190	121495	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	CHEMBL3593815	121495	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	57422768	112955	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	615	8	2	10	3.8	Cc1ccn(-c2ccc(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c(Cl)c2)n1	10.1021/jm500610n
	CHEMBL3319228	112955	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	615	8	2	10	3.8	Cc1ccn(-c2ccc(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c(Cl)c2)n1	10.1021/jm500610n
	16114096	78750	1	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1	10.1021/jm0704550
	CHEMBL2113324	78750	1	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1	10.1021/jm0704550
	178024	1940	30	None	-	1	Human	9.3	pIC50	=	9.3	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cells	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020424z
	5867	1940	30	None	-	1	Human	9.3	pIC50	=	9.3	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cells	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020424z
	CHEMBL13817	1940	30	None	-	1	Human	9.3	pIC50	=	9.3	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cells	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020424z
	57422690	112954	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	615	8	2	10	3.8	Cc1ccn(-c2ccc(Cl)c(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c2)n1	10.1021/jm500610n
	CHEMBL3319227	112954	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	615	8	2	10	3.8	Cc1ccn(-c2ccc(Cl)c(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c2)n1	10.1021/jm500610n
	118709503	112974	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	588	7	2	9	3.8	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc5c(ccn5C)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319399	112974	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	588	7	2	9	3.8	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc5c(ccn5C)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	66788278	124672	0	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
	CHEMBL3645254	124672	0	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
	16114292	96486	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm701292s
	CHEMBL266063	96486	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm701292s
	44436850	91118	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	564	11	4	6	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL240509	91118	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	564	11	4	6	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	57422793	112971	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	631	9	2	11	3.5	COc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1021/jm500610n
	CHEMBL3319396	112971	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	631	9	2	11	3.5	COc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1021/jm500610n
	178024	1940	30	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	5867	1940	30	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	CHEMBL13817	1940	30	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	57422688	112952	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	601	8	2	10	3.5	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319225	112952	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	601	8	2	10	3.5	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	57785733	112951	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	612	8	2	9	4.4	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-c5ccccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319224	112951	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	612	8	2	9	4.4	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-c5ccccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	16113245	120820	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581030	120820	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	44445600	154250	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	542	10	2	6	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL400175	154250	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	542	10	2	6	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL437713	211983	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cells	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm020424z
	178024	1940	30	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
	5867	1940	30	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
	CHEMBL13817	1940	30	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
	CHEMBL412799	211278	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(N)=O)C(C)C	10.1021/jm0001727
	57422817	112950	13	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	620	8	2	10	3.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319223	112950	13	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	620	8	2	10	3.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	11476589	75635	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205451	75635	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL526723	213921	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
	44436857	145123	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	594	12	4	7	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL391588	145123	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	594	12	4	7	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	90666039	108834	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	528	8	0	9	4.2	CCOc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218912	108834	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	528	8	0	9	4.2	CCOc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	118709505	112982	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	561	5	2	8	4.4	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319406	112982	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	561	5	2	8	4.4	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL2310887	207747	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCC(CCC)C(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
	122180026	121073	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586032	121073	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	122182043	121484	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL3593632	121484	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL2310890	207749	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		C/C=C/C=C/C=C/C(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
	44409536	75158	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	579	9	3	8	5.2	Nc1nc(N)c(-c2ccc(NCc3cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL204325	75158	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	579	9	3	8	5.2	Nc1nc(N)c(-c2ccc(NCc3cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	44445595	93967	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL250974	93967	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	90665850	108789	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	491	7	0	7	4.6	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3cn(-c4ccc(Cl)cc4)nc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218650	108789	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	491	7	0	7	4.6	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3cn(-c4ccc(Cl)cc4)nc3c2=O)C1	10.1039/C2MD20340E
	90665851	108790	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	459	5	0	6	4.8	Cc1ccccc1-c1nc2cn(-c3ccc(F)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL3218651	108790	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	459	5	0	6	4.8	Cc1ccccc1-c1nc2cn(-c3ccc(F)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	11134880	98972	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	500	10	6	4	2.1	O=CN[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
	CHEMBL282891	98972	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	500	10	6	4	2.1	O=CN[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
	5866	3567	3	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1021/jm040103i
	9804743	3567	3	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1021/jm040103i
	CHEMBL360227	3567	3	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1021/jm040103i
	11712151	75640	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	453	9	3	7	4.8	CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205470	75640	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	453	9	3	7	4.8	CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	56942098	124673	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
	CHEMBL3645255	124673	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
	25261382	112942	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	535	7	2	8	3.3	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319215	112942	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	535	7	2	8	3.3	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	57422789	112956	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	629	8	2	10	4.1	Cc1cc(C)n(-c2ccc(Cl)c(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c2)n1	10.1021/jm500610n
	CHEMBL3319229	112956	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	629	8	2	10	4.1	Cc1cc(C)n(-c2ccc(Cl)c(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c2)n1	10.1021/jm500610n
	56942244	124677	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	nan
	CHEMBL3645259	124677	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	nan
	90665846	108785	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	491	5	0	5	6.9	Cc1ccccc1-c1nc2cc(-c3ccc(Cl)cc3)sc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL3218646	108785	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	491	5	0	5	6.9	Cc1ccccc1-c1nc2cc(-c3ccc(Cl)cc3)sc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	11339816	75654	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	446	8	3	7	4.7	Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205521	75654	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	446	8	3	7	4.7	Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	44409756	76414	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	492	8	4	8	4.1	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206820	76414	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	492	8	4	8	4.1	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	90666012	108807	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	475	5	0	6	5.3	Cc1ccccc1-c1nc2cn(-c3cccc(Cl)c3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL3218885	108807	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	475	5	0	6	5.3	Cc1ccccc1-c1nc2cn(-c3cccc(Cl)c3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	90666031	108826	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	498	7	0	8	4.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218904	108826	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	498	7	0	8	4.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	44390840	123039	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(Cl)c2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL361804	123039	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(Cl)c2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	90666017	108812	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	472	6	0	8	4.1	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218890	108812	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	472	6	0	8	4.1	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	90666027	108822	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	502	8	0	9	3.7	COC[C@H](C)N1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218900	108822	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	502	8	0	9	3.7	COC[C@H](C)N1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	44445594	154105	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	611	11	3	7	6.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL399447	154105	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	611	11	3	7	6.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	90666013	108808	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	471	6	0	7	4.7	COc1cccc(-n2cc3nc(-c4ccccc4C)n(CC4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218886	108808	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	471	6	0	7	4.7	COc1cccc(-n2cc3nc(-c4ccccc4C)n(CC4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	44445599	93750	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	581	10	3	6	6.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL249639	93750	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	581	10	3	6	6.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	44446187	94184	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252255	94184	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	178024	1940	30	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	5867	1940	30	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	CHEMBL13817	1940	30	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	23648244	91582	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL241775	91582	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	44409776	76790	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	7	3	7	3.5	CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207754	76790	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	7	3	7	3.5	CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122178616	120838	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581048	120838	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	16113471	84297	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	623	10	4	5	6.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(Br)cc1	10.1021/jm070024h
	CHEMBL222789	84297	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	623	10	4	5	6.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(Br)cc1	10.1021/jm070024h
	156021766	177553	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648355	177553	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145959787	161735	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	161735	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145953855	161965	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167669	161965	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	16113585	136711	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	591	11	4	7	5.0	COc1ccc(Cn2c(Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	CHEMBL375161	136711	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	591	11	4	7	5.0	COc1ccc(Cn2c(Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	145958774	161716	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163811	161716	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	156016073	177081	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@@H](C)C1	10.1016/j.bmcl.2020.126953
	CHEMBL4641503	177081	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@@H](C)C1	10.1016/j.bmcl.2020.126953
	162646061	178951	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of GHSR-1A (unknown origin)Inhibition of GHSR-1A (unknown origin)	ChEMBL	729	18	11	12	-5.4	C[C@@H](O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CN)NC(=O)[C@H](CO)NC(=O)CN)C(N)=O	10.1039/d0md00210k
	CHEMBL4741413	178951	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of GHSR-1A (unknown origin)Inhibition of GHSR-1A (unknown origin)	ChEMBL	729	18	11	12	-5.4	C[C@@H](O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CN)NC(=O)[C@H](CO)NC(=O)CN)C(N)=O	10.1039/d0md00210k
	70692600	75521	0	None	-	1	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	447	7	0	7	2.8	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048813	75521	0	None	-	1	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	447	7	0	7	2.8	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2310886	207746	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCNC(=O)CCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
	156021766	177553	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648355	177553	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44445601	93751	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	498	8	2	5	5.4	O=C(N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1-c1ccccc1)c1ccccn1	10.1021/jm701292s
	CHEMBL249640	93751	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	498	8	2	5	5.4	O=C(N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1-c1ccccc1)c1ccccn1	10.1021/jm701292s
	44390901	63748	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(OC)cc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL180755	63748	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(OC)cc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	145959787	161735	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	161735	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	70694648	75519	0	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	462	7	0	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4nnc(C)o4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048811	75519	0	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	462	7	0	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4nnc(C)o4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	44445591	154104	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	591	11	4	7	5.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL399446	154104	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	591	11	4	7	5.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	16113468	141268	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	CHEMBL386218	141268	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	16113468	141268	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL386218	141268	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	46882103	5877	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	12	4	4	4.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCCN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079872	5877	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	12	4	4	4.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCCN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	72190450	91843	0	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426679	91843	0	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	11441978	129933	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	437	8	2	4	4.8	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OCC(C)C)CCc3ccccc3C2)cc1	10.1021/jm0491750
	CHEMBL368034	129933	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	437	8	2	4	4.8	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OCC(C)C)CCc3ccccc3C2)cc1	10.1021/jm0491750
	CHEMBL2310894	207752	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)c1ccccc1)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm0001727
	122180017	121064	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	525	9	2	8	4.5	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586023	121064	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	525	9	2	8	4.5	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	44445592	93749	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL249638	93749	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	16113577	84512	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	573	12	4	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	CHEMBL223725	84512	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	573	12	4	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	16113902	137151	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL375859	137151	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	90666041	108836	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	542	8	0	9	4.6	Cc1ncccc1-c1nc2cn(-c3cccc(OC(C)C)c3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
	CHEMBL3218914	108836	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	542	8	0	9	4.6	Cc1ncccc1-c1nc2cn(-c3cccc(OC(C)C)c3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
	16113902	137151	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL375859	137151	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	15945877	146406	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCCN2)cc1	10.1021/jm0704550
	CHEMBL392593	146406	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCCN2)cc1	10.1021/jm0704550
	11337482	76287	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	CHEMBL206399	76287	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	44409775	75672	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	8	3	7	3.7	CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205605	75672	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	8	3	7	3.7	CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122182190	121495	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	CHEMBL3593815	121495	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	44445620	154140	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	571	11	2	6	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL399651	154140	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	571	11	2	6	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	11676995	65831	1	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	461	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL184258	65831	1	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	461	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1	10.1016/j.bmcl.2004.06.060
	16203930	83918	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1cc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc(OC)c1	10.1021/jm070024h
	CHEMBL221674	83918	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1cc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc(OC)c1	10.1021/jm070024h
	11537683	75176	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	354	5	3	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1	10.1021/jm0510934
	CHEMBL204352	75176	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	354	5	3	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1	10.1021/jm0510934
	122180020	121067	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586026	121067	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	44338247	7845	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	549	11	1	6	4.8	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1CCCN1CCCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL109035	7845	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	549	11	1	6	4.8	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1CCCN1CCCC1	10.1016/j.bmcl.2003.11.012
	44445622	154141	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	625	11	4	7	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccc2N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL399653	154141	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	625	11	4	7	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccc2N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	59446139	81189	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	849	21	10	8	2.2	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163449	81189	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	849	21	10	8	2.2	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44436812	91332	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	11	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](C)N)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL241033	91332	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	11	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](C)N)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	11731384	162170	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	557	10	7	5	2.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCN1	10.1021/jm020985q
	CHEMBL417092	162170	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	557	10	7	5	2.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCN1	10.1021/jm020985q
	44390888	64085	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	435	7	2	4	2.7	CCN(CC)CCN1C(=O)C(O)(c2ccccc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL181312	64085	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	435	7	2	4	2.7	CCN(CC)CCN1C(=O)C(O)(c2ccccc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	60195112	81194	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	875	21	10	8	2.6	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163466	81194	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	875	21	10	8	2.6	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2370788	208176	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm020985q
	16113904	136512	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL374655	136512	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	90665852	108791	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	466	5	0	7	4.6	Cc1ccccc1-c1nc2cn(-c3ccc(C#N)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL3218652	108791	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	466	5	0	7	4.6	Cc1ccccc1-c1nc2cn(-c3ccc(C#N)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	90666032	108827	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	512	7	0	8	4.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218905	108827	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	512	7	0	8	4.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	16113904	136512	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL374655	136512	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL500703	212349	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1074/jbc.m609796200
	10415364	126246	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Inhibitory concentration against rat Growth hormone secretagogue receptorInhibitory concentration against rat Growth hormone secretagogue receptor	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL365294	126246	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Inhibitory concentration against rat Growth hormone secretagogue receptorInhibitory concentration against rat Growth hormone secretagogue receptor	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	53390181	91839	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426675	91839	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	145957075	161729	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164040	161729	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	145956026	162112	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4169979	162112	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145956061	162143	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170481	162143	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	145951150	162226	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4171914	162226	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	11328064	159765	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	437	6	2	4	4.9	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OC(C)(C)C)CCc3ccccc3C2)cc1	10.1021/jm0491750
	CHEMBL411055	159765	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	437	6	2	4	4.9	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OC(C)(C)C)CCc3ccccc3C2)cc1	10.1021/jm0491750
	44445607	166177	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.4	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL428314	166177	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.4	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	16113581	84713	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1cccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL224921	84713	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1cccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	90666022	108817	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	528	7	0	9	4.2	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218895	108817	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	528	7	0	9	4.2	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	90666028	108823	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	511	7	0	10	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(Cc5cnco5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218901	108823	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	511	7	0	10	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(Cc5cnco5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	70682036	75525	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	446	7	1	4	4.3	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4n[nH]c5ccccc45)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048817	75525	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	446	7	1	4	4.3	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4n[nH]c5ccccc45)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	16113796	84258	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL222518	84258	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	57422697	112962	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	409	3	2	6	3.3	CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319276	112962	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	409	3	2	6	3.3	CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	44582528	192813	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL	3419	113	48	48	-14.7	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm8014519
	91935097	192813	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL	3419	113	48	48	-14.7	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm8014519
	CHEMBL525994	192813	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL	3419	113	48	48	-14.7	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm8014519
	CHEMBL499371	212324	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O	10.1074/jbc.m609796200
	59446101	81204	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	915	23	11	9	2.1	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163477	81204	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	915	23	11	9	2.1	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	59446101	81204	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	915	23	11	9	2.1	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163477	81204	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	915	23	11	9	2.1	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44389262	121518	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	479	6	2	4	6.1	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359506	121518	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	479	6	2	4	6.1	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1	10.1016/j.bmcl.2004.11.075
	16113796	84258	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL222518	84258	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	11576960	66779	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	500	8	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL187427	66779	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	500	8	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	11124146	98696	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	518	10	6	5	2.8	CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL281173	98696	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	518	10	6	5	2.8	CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	122178600	120822	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581033	120822	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	44409679	75157	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	466	8	4	8	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204322	75157	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	466	8	4	8	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	9745	2420	20	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	9804938	2420	20	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	CHEMBL278623	2420	20	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	DB13074	2420	20	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	16113579	84513	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	595	10	4	5	6.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1cccc2ccccc12	10.1021/jm070024h
	CHEMBL223726	84513	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	595	10	4	5	6.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1cccc2ccccc12	10.1021/jm070024h
	CHEMBL3578015	210019	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	145954311	161936	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167267	161936	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL3578015	210019	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	11373823	78094	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	431	7	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)c3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL211188	78094	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	431	7	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)c3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	145954311	161936	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167267	161936	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	44301389	11170	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179118	11170	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL61292	11170	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	46882236	5695	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	8	4	4	4.1	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078608	5695	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	8	4	4	4.1	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	16114514	78748	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1	10.1021/jm0704550
	CHEMBL2113322	78748	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1	10.1021/jm0704550
	11523411	75204	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	363	6	4	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1	10.1021/jm0510934
	CHEMBL204511	75204	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	363	6	4	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1	10.1021/jm0510934
	57422730	112939	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	508	9	2	7	4.4	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319212	112939	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	508	9	2	7	4.4	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	46882763	5552	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK0677 from human GHS-R1aDisplacement of [35S]MK0677 from human GHS-R1a	ChEMBL	612	17	6	7	5.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1077617	5552	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK0677 from human GHS-R1aDisplacement of [35S]MK0677 from human GHS-R1a	ChEMBL	612	17	6	7	5.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44576247	212451	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212451	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	145951150	162226	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4171914	162226	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL433540	211894	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cells	ChEMBL		None	None	None		C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm020424z
	1744826	62669	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1021/jm0491750
	CHEMBL178668	62669	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1021/jm0491750
	1744826	62669	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Binding affinity to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL178668	62669	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Binding affinity to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.06.060
	122178603	120825	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581036	120825	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	16114009	136670	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	556	10	3	5	5.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1cccc2ccccc12	10.1021/jm070024h
	CHEMBL374921	136670	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	556	10	3	5	5.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1cccc2ccccc12	10.1021/jm070024h
	23648246	161239	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL414132	161239	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	11655578	169466	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	462	8	3	7	5.2	Nc1nc(N)c(-c2ccc(NCc3cnc4ccccc4c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL444277	169466	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	462	8	3	7	5.2	Nc1nc(N)c(-c2ccc(NCc3cnc4ccccc4c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	1744826	62669	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178668	62669	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	156021336	177593	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	467	5	1	6	5.2	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	CHEMBL4649089	177593	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	467	5	1	6	5.2	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	44446190	94120	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL251855	94120	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	44389167	123340	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	425	7	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL362612	123340	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	425	7	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44338240	108652	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	569	11	1	7	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2cc(-c3ccccc3-c3nn[nH]n3)cs2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL321403	108652	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	569	11	1	7	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2cc(-c3ccccc3-c3nn[nH]n3)cs2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	11539587	66742	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	445	8	1	4	6.7	CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL187271	66742	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	445	8	1	4	6.7	CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	11503585	64873	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	461	9	2	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL182542	64873	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	461	9	2	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1	10.1016/j.bmcl.2004.06.060
	23656300	148234	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	592	12	3	7	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2)c(OC)c1	10.1021/jm0704550
	CHEMBL394054	148234	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	592	12	3	7	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2)c(OC)c1	10.1021/jm0704550
	59446107	81207	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163480	81207	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	59446107	81207	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163480	81207	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44436807	147779	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	547	11	3	7	4.6	COc1ccc(Cn2c(CCC3C=Nc4ccccc43)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
	CHEMBL393692	147779	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	547	11	3	7	4.6	COc1ccc(Cn2c(CCC3C=Nc4ccccc43)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
	46882237	5703	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	466	9	4	4	4.1	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078677	5703	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	466	9	4	4	4.1	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44395002	65855	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	534	9	1	5	5.6	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL184368	65855	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	534	9	1	5	5.6	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1	10.1016/j.bmcl.2004.06.060
	44445627	154401	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	543	10	2	7	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL401084	154401	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	543	10	2	7	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	16113906	136699	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	612	12	5	5	6.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	CHEMBL375102	136699	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	612	12	5	5	6.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	70692601	75522	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	481	7	0	7	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048814	75522	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	481	7	0	7	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	145957075	161729	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164040	161729	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	145956026	162112	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4169979	162112	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145956061	162143	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170481	162143	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	46882271	5732	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	466	8	4	4	5.0	CCc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078899	5732	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	466	8	4	4	5.0	CCc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	156018364	177339	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645148	177339	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44445624	154367	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	631	11	4	7	5.8	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)[C@H]2CCCC[C@H]2N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL400879	154367	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	631	11	4	7	5.8	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)[C@H]2CCCC[C@H]2N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	16203238	136585	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	531	9	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1	10.1021/jm070024h
	CHEMBL374757	136585	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	531	9	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1	10.1021/jm070024h
	16113694	136669	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	609	11	4	5	6.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1cccc2ccccc12	10.1021/jm070024h
	CHEMBL374920	136669	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	609	11	4	5	6.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1cccc2ccccc12	10.1021/jm070024h
	16114181	141408	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	10	3	5	5.0	Cc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL387109	141408	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	10	3	5	5.0	Cc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	44446137	154878	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL403682	154878	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	122180017	121064	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	525	9	2	8	4.5	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586023	121064	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	525	9	2	8	4.5	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	44379072	12689	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	492	8	2	5	4.2	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1188124	12689	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	492	8	2	5	4.2	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL535353	12689	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	492	8	2	5	4.2	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	16113905	84273	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	589	12	4	6	5.6	COc1ccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL222622	84273	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	589	12	4	6	5.6	COc1ccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	11626181	123862	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	431	7	1	4	6.3	CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363896	123862	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	431	7	1	4	6.3	CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	42624369	188276	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1713	58	25	24	-9.3	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	44582535	188276	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1713	58	25	24	-9.3	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	91935102	188276	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1713	58	25	24	-9.3	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	CHEMBL506930	188276	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1713	58	25	24	-9.3	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	16113691	136196	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	CHEMBL374073	136196	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	90666023	108818	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218896	108818	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	16113691	136196	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm0704550
	CHEMBL374073	136196	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm0704550
	57422696	112979	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	558	5	2	9	4.0	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319403	112979	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	558	5	2	9	4.0	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	156012849	176724	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636571	176724	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44390860	63313	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(Cl)c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL180096	63313	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(Cl)c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	73347725	91838	0	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	476	6	0	5	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4ncccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426674	91838	0	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	476	6	0	5	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4ncccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2013.07.044
	156012849	176724	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636571	176724	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156015928	177007	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640615	177007	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156018364	177339	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645148	177339	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145949595	162174	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171040	162174	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	1100	1578	41	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		None	10.1021/jm300557t
	6918297	1578	41	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		None	10.1021/jm300557t
	CHEMBL108335	1578	41	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		None	10.1021/jm300557t
	11539588	66579	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	445	7	1	4	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C(C)C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL186540	66579	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	445	7	1	4	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C(C)C)cc1	10.1016/j.bmcl.2004.06.060
	122180015	121062	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	523	9	2	8	5.3	CCCn1cc(-c2cnc(NCc3ccc4occc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586021	121062	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	523	9	2	8	5.3	CCCn1cc(-c2cnc(NCc3ccc4occc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	122178615	120790	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3580668	120790	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	16113798	83916	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	598	11	5	5	5.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	CHEMBL221662	83916	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	598	11	5	5	5.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	16113797	137609	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	637	11	4	5	6.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccc(Br)cc1	10.1021/jm070024h
	CHEMBL376735	137609	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	637	11	4	5	6.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccc(Br)cc1	10.1021/jm070024h
	16113903	167813	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1cc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc(OC)c1	10.1021/jm070024h
	CHEMBL434573	167813	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1cc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc(OC)c1	10.1021/jm070024h
	44338241	6463	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	569	11	1	7	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)s2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL108287	6463	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	569	11	1	7	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)s2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	44410012	137871	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	439	9	3	7	4.1	CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL377305	137871	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	439	9	3	7	4.1	CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16113122	147636	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	538	12	3	7	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)c(OC)c1	10.1021/jm0704550
	CHEMBL393565	147636	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	538	12	3	7	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)c(OC)c1	10.1021/jm0704550
	11556937	81210	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163484	81210	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	11556937	81210	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163484	81210	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	9956908	12985	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	482	12	2	5	4.5	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1190326	12985	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	482	12	2	5	4.5	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL540604	12985	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	482	12	2	5	4.5	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	11329138	64129	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1021/jm0491750
	CHEMBL181350	64129	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1021/jm0491750
	90665848	108787	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	507	7	0	6	6.1	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3cc(-c4ccc(Cl)cc4)sc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218648	108787	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	507	7	0	6	6.1	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3cc(-c4ccc(Cl)cc4)sc3c2=O)C1	10.1039/C2MD20340E
	23648245	91583	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL241776	91583	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	145949595	162174	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171040	162174	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	11846625	77531	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	498	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL209394	77531	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	498	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	44409683	75906	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	480	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205848	75906	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	480	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46882305	5751	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	494	7	4	4	5.7	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccc(C(C)(C)C)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079091	5751	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	494	7	4	4	5.7	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccc(C(C)(C)C)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	11124146	98696	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	518	10	6	5	2.8	CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL281173	98696	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	518	10	6	5	2.8	CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	56942855	124679	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	601	10	2	6	7.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2ccc3ccccc3c2)NC(=O)OC(C)(C)C)cc1	nan
	CHEMBL3645261	124679	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	601	10	2	6	7.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2ccc3ccccc3c2)NC(=O)OC(C)(C)C)cc1	nan
	11016748	97898	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	517	10	7	4	2.4	CCNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL275141	97898	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	517	10	7	4	2.4	CCNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	44445602	93752	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	537	8	3	5	5.9	O=C(N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)c1ccccn1	10.1021/jm701292s
	CHEMBL249659	93752	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	537	8	3	5	5.9	O=C(N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)c1ccccn1	10.1021/jm701292s
	11256439	75029	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	344	5	3	6	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C#N)cc2)cc1	10.1021/jm0510934
	CHEMBL203843	75029	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	344	5	3	6	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C#N)cc2)cc1	10.1021/jm0510934
	44390881	65772	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2ccccc2OC)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL183916	65772	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2ccccc2OC)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	44338151	109261	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	581	11	1	6	5.3	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2F)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL323026	109261	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	581	11	1	6	5.3	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2F)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	46882238	5706	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1ccccc1NC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078699	5706	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1ccccc1NC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	59446133	174462	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)N(Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL4567432	174462	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)N(Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	60195284	81198	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)N(Cc1ccccc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163471	81198	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)N(Cc1ccccc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44394930	66000	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185028	66000	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1	10.1016/j.bmcl.2004.06.060
	11016748	97898	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	517	10	7	4	2.4	CCNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL275141	97898	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	517	10	7	4	2.4	CCNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	59446115	173738	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)N(Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL4550305	173738	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)N(Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	60195379	81202	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)N(Cc1ccc(-c2ccccc2)cc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163475	81202	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)N(Cc1ccc(-c2ccccc2)cc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	46882155	5632	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	8	4	4	3.3	CCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078114	5632	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	8	4	4	3.3	CCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	11145720	67003	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	11	6	4	2.9	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)NC	10.1021/jm020985q
	CHEMBL18853	67003	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	11	6	4	2.9	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)NC	10.1021/jm020985q
	11846628	77359	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	431	7	2	6	4.2	CN(C(=O)C1CCCC1)c1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL208930	77359	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	431	7	2	6	4.2	CN(C(=O)C1CCCC1)c1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	156015928	177007	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640615	177007	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	16114012	167835	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	510	9	3	5	4.7	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccc(F)cc1	10.1021/jm070024h
	CHEMBL434738	167835	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	510	9	3	5	4.7	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccc(F)cc1	10.1021/jm070024h
	122180018	121065	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	527	9	2	9	4.3	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586024	121065	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	527	9	2	9	4.3	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	16113582	136116	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	455	7	4	5	3.5	Cn1c(Cc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL373995	136116	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	455	7	4	5	3.5	Cn1c(Cc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	46882807	5687	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	10	4	4	3.6	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078533	5687	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	10	4	4	3.6	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	16114184	149958	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	564	11	4	7	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@@H](O)CN2)cc1	10.1021/jm0704550
	CHEMBL395441	149958	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	564	11	4	7	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@@H](O)CN2)cc1	10.1021/jm0704550
	44446188	154852	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL403542	154852	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	44436817	166216	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	600	13	4	6	5.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](N)Cc3ccccc3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL428383	166216	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	600	13	4	6	5.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](N)Cc3ccccc3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44445618	161349	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	570	12	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)CCc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL415134	161349	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	570	12	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)CCc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	44436887	90528	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	11	5	6	3.7	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL239464	90528	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	11	5	6	3.7	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	10907396	98693	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	515	10	7	5	1.2	NC1(C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)NC=O)CCNCC1	10.1021/jm020985q
	CHEMBL281147	98693	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	515	10	7	5	1.2	NC1(C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)NC=O)CCNCC1	10.1021/jm020985q
	11649239	66008	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	514	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185057	66008	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	514	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	1100	1578	41	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		None	10.1021/jm020985q
	6918297	1578	41	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		None	10.1021/jm020985q
	CHEMBL108335	1578	41	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		None	10.1021/jm020985q
	16113580	137353	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm701292s
	CHEMBL376258	137353	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm701292s
	16113580	137353	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL376258	137353	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	44436883	145620	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	604	11	6	7	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1	10.1021/jm0704550
	CHEMBL391980	145620	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	604	11	6	7	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1	10.1021/jm0704550
	44436889	152523	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	11	3	5	6.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL397594	152523	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	11	3	5	6.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	11452801	138768	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	417	7	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL379191	138768	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	417	7	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	44445625	154281	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	612	11	3	8	5.4	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL400381	154281	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	612	11	3	8	5.4	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	122180019	121066	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586025	121066	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	145957443	161540	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160928	161540	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	10864048	97936	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.6	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL275373	97936	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.6	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	44389187	63691	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3cccc(Cl)c3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL180722	63691	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3cccc(Cl)c3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44409871	75046	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	426	7	3	8	2.4	CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203948	75046	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	426	7	3	8	2.4	CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145959007	161707	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163623	161707	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	145956659	161506	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160434	161506	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	145959787	161735	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	161735	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	16113248	78754	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL2113328	78754	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	11282247	165373	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL425048	165373	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	11282247	165373	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL425048	165373	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	44409802	76391	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	439	9	3	7	4.1	CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206687	76391	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	439	9	3	7	4.1	CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	156019457	177368	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645625	177368	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	216208	9635	27	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	CHEMBL113313	9635	27	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	90666037	108832	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	484	6	0	8	3.8	Cc1ncccc1-c1nc2cn(-c3ccccc3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
	CHEMBL3218910	108832	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	484	6	0	8	3.8	Cc1ncccc1-c1nc2cn(-c3ccccc3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
	23648236	78742	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	13	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1	10.1021/jm0704550
	CHEMBL2113317	78742	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	13	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1	10.1021/jm0704550
	44383343	119836	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	606	6	2	5	3.4	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)C3Cc4ccccc4CN3)CC2)c2ccccc21	10.1021/jm0309452
	CHEMBL353007	119836	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	606	6	2	5	3.4	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)C3Cc4ccccc4CN3)CC2)c2ccccc21	10.1021/jm0309452
	156014693	176618	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	530	6	2	8	2.9	CCOc1cc(Cl)c(-c2ccc(-c3nc4c(s3)CN(C(=O)CO)CC4)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	CHEMBL4635089	176618	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	530	6	2	8	2.9	CCOc1cc(Cl)c(-c2ccc(-c3nc4c(s3)CN(C(=O)CO)CC4)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	44389151	62176	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	445	6	1	4	5.7	CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	CHEMBL178138	62176	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	445	6	1	4	5.7	CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	44409979	140029	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	7	2	7	3.4	CCc1nc(N)nc(N(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL381159	140029	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	7	2	7	3.4	CCc1nc(N)nc(N(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44395020	123514	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	507	9	1	5	6.1	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL363021	123514	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	507	9	1	5	6.1	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1	10.1016/j.bmcl.2004.06.060
	16114530	84316	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	539	13	4	5	5.7	CCCCCCn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL222912	84316	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	539	13	4	5	5.7	CCCCCCn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	59446130	81206	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	800	21	10	9	0.4	CC(C)CN(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163479	81206	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	800	21	10	9	0.4	CC(C)CN(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	59446130	81206	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	800	21	10	9	0.4	CC(C)CN(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163479	81206	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	800	21	10	9	0.4	CC(C)CN(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44409761	75513	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	9	3	7	4.4	CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204880	75513	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	9	3	7	4.4	CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145956659	161506	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160434	161506	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	145957443	161540	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160928	161540	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	145959007	161707	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163623	161707	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	145959787	161735	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	161735	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	11328920	143510	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	471	8	2	4	5.4	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OCC(C)C)CCc3cccc(Cl)c3C2)cc1	10.1021/jm0491750
	CHEMBL390308	143510	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	471	8	2	4	5.4	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OCC(C)C)CCc3cccc(Cl)c3C2)cc1	10.1021/jm0491750
	122178606	120828	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581039	120828	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	122178609	120832	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581042	120832	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	178024	1940	30	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	5867	1940	30	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	CHEMBL13817	1940	30	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	44409821	75684	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	564	10	4	8	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205711	75684	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	564	10	4	8	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46882307	5753	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	530	8	4	4	6.0	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NC(C)(C)c3cccc4ccccc34)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079108	5753	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	530	8	4	4	6.0	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NC(C)(C)c3cccc4ccccc34)cc2)cc1	10.1016/j.bmcl.2009.08.076
	122182044	121485	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	552	9	2	6	4.9	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL3593633	121485	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	552	9	2	6	4.9	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	5866	3567	3	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1016/j.bmcl.2005.02.042
	9804743	3567	3	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1016/j.bmcl.2005.02.042
	CHEMBL360227	3567	3	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1016/j.bmcl.2005.02.042
	CHEMBL500468	212344	0	None	-	1	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm501702q
	CHEMBL500468	212344	0	None	-	1	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm501702q
	11683469	76353	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	433	6	3	7	3.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1	10.1021/jm0510934
	CHEMBL206486	76353	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	433	6	3	7	3.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1	10.1021/jm0510934
	11454617	140788	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	488	8	3	8	4.0	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383411	140788	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	488	8	3	8	4.0	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2006.01.012
	90666029	108824	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	510	7	0	9	4.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(Cc5ccco5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218902	108824	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	510	7	0	9	4.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(Cc5ccco5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	44409672	139957	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	479	9	3	9	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccco3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL380971	139957	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	479	9	3	9	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccco3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11154823	75676	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	436	8	3	7	4.5	N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205660	75676	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	436	8	3	7	4.5	N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	11190594	75632	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	469	10	3	8	3.9	CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205445	75632	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	469	10	3	8	3.9	CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11583811	75634	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	479	8	3	6	5.7	Nc1nc(N)c(-c2ccc(NCc3ccc(C(F)(F)F)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205450	75634	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	479	8	3	6	5.7	Nc1nc(N)c(-c2ccc(NCc3ccc(C(F)(F)F)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	25260900	112978	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	593	10	2	9	4.3	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(N4CCOCC4)ccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319402	112978	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	593	10	2	9	4.3	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(N4CCOCC4)ccc3Cl)sc2c1	10.1021/jm500610n
	10918326	98515	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N(C)C	10.1021/jm020985q
	CHEMBL279822	98515	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N(C)C	10.1021/jm020985q
	44378981	13857	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	504	10	2	5	5.5	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1196773	13857	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	504	10	2	5	5.5	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL558181	13857	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	504	10	2	5	5.5	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	90666033	108828	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	526	7	0	8	5.3	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218906	108828	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	526	7	0	8	5.3	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	16113472	168440	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL439251	168440	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	66813470	76479	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]ghrelin from GHS receptorDisplacement of [125I]ghrelin from GHS receptor	ChEMBL	459	6	2	6	3.3	O=C(N[C@@H]1COc2cccc(-c3ccc(CO)nc3)c2C1)c1ccc(OCC(F)(F)F)nc1	10.1016/j.bmcl.2012.06.105
	CHEMBL2069411	76479	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]ghrelin from GHS receptorDisplacement of [125I]ghrelin from GHS receptor	ChEMBL	459	6	2	6	3.3	O=C(N[C@@H]1COc2cccc(-c3ccc(CO)nc3)c2C1)c1ccc(OCC(F)(F)F)nc1	10.1016/j.bmcl.2012.06.105
	122180022	121069	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	504	7	2	9	2.8	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2CCOCC2)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586028	121069	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	504	7	2	9	2.8	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2CCOCC2)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	70694649	75531	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	475	5	0	7	3.2	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-n3nccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	CHEMBL2048823	75531	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	475	5	0	7	3.2	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-n3nccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	10100708	11929	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL1183387	11929	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL294408	11929	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	11577349	64900	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	529	9	1	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL182655	64900	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	529	9	1	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1	10.1016/j.bmcl.2004.06.060
	16114098	141079	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	534	11	3	5	5.4	Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL385131	141079	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	534	11	3	5	5.4	Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	11327400	75022	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	412	8	3	7	4.0	Nc1nc(N)c(-c2ccc(NCc3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL203782	75022	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	412	8	3	7	4.0	Nc1nc(N)c(-c2ccc(NCc3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	44409455	75615	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	487	6	3	7	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1	10.1021/jm0510934
	CHEMBL205286	75615	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	487	6	3	7	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1	10.1021/jm0510934
	156019457	177368	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645625	177368	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	46882306	5752	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	502	8	4	4	5.2	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCc3cccc4ccccc34)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079107	5752	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	502	8	4	4	5.2	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCc3cccc4ccccc34)cc2)cc1	10.1016/j.bmcl.2009.08.076
	11731384	162170	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	557	10	7	5	2.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCN1	10.1021/jm020985q
	CHEMBL417092	162170	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	557	10	7	5	2.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCN1	10.1021/jm020985q
	118709470	112960	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	395	3	2	5	4.6	COc1ccc2nc(NC(=O)NC(=O)c3c(Cl)cccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319274	112960	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	395	3	2	5	4.6	COc1ccc2nc(NC(=O)NC(=O)c3c(Cl)cccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL507636	212662	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1074/jbc.m609796200
	156021885	177641	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	635	10	1	10	4.2	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1CCO[C@H](C)C1	10.1016/j.bmcl.2020.126953
	CHEMBL4649741	177641	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	635	10	1	10	4.2	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1CCO[C@H](C)C1	10.1016/j.bmcl.2020.126953
	70688404	75514	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048807	75514	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2012.05.024
	11114279	97797	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	544	12	6	4	3.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1021/jm020985q
	CHEMBL274460	97797	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	544	12	6	4	3.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1021/jm020985q
	70688404	75514	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2048807	75514	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2013.07.044
	16113693	137489	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	589	12	4	6	5.6	COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL376471	137489	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	589	12	4	6	5.6	COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	216208	9635	27	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	CHEMBL113313	9635	27	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	11827047	98763	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	488	11	6	4	2.1	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O	10.1021/jm020985q
	CHEMBL281578	98763	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	488	11	6	4	2.1	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O	10.1021/jm020985q
	9745	2420	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	9804938	2420	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	CHEMBL278623	2420	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	DB13074	2420	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	16113124	120821	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccncc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581032	120821	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccncc2)cc1	10.1016/j.bmcl.2014.11.031
	44445605	154442	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	542	10	2	6	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL401260	154442	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	542	10	2	6	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	16113578	136668	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	542	9	3	5	5.7	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1cccc2ccccc12	10.1021/jm070024h
	CHEMBL374919	136668	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	542	9	3	5	5.7	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1cccc2ccccc12	10.1021/jm070024h
	16113584	137069	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	441	7	5	4	3.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2c[nH]c3ccccc23)[nH]1	10.1021/jm070024h
	CHEMBL375568	137069	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	441	7	5	4	3.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2c[nH]c3ccccc23)[nH]1	10.1021/jm070024h
	44389168	64542	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	457	4	1	4	5.8	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1	10.1016/j.bmcl.2004.11.075
	CHEMBL182154	64542	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	457	4	1	4	5.8	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1	10.1016/j.bmcl.2004.11.075
	11314908	141280	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	377	7	3	6	3.4	CCC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL386290	141280	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	377	7	3	6	3.4	CCC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	11846627	79314	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	363	6	3	6	3.0	CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL211581	79314	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	363	6	3	6	3.0	CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	10929048	68465	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	488	9	6	4	2.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL19220	68465	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	488	9	6	4	2.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	90666020	108815	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	500	7	0	9	3.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218893	108815	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	500	7	0	9	3.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	16114403	146654	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2)cc1	10.1021/jm0704550
	CHEMBL392805	146654	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2)cc1	10.1021/jm0704550
	57422673	112967	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	474	4	2	7	4.1	CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccc4)ccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319282	112967	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	474	4	2	7	4.1	CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccc4)ccc3Cl)sc2c1	10.1021/jm500610n
	70684154	75516	0	None	-	1	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	414	6	0	4	3.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048809	75516	0	None	-	1	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	414	6	0	4	3.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	122180020	121067	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586026	121067	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	16113710	78751	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1	10.1021/jm0704550
	CHEMBL2113325	78751	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1	10.1021/jm0704550
	122178611	120834	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581044	120834	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	122178614	120837	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581047	120837	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	16114531	84252	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	553	14	4	5	6.1	CCCCCCn1c(CCCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL222498	84252	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	553	14	4	5	6.1	CCCCCCn1c(CCCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	145974293	162474	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175823	162474	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	46882197	5665	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	10	4	4	4.1	CCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078403	5665	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	10	4	4	4.1	CCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44409980	75827	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	8	3	7	3.7	CCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205790	75827	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	8	3	7	3.7	CCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145952740	161951	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4167481	161951	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	44409868	76389	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	487	9	3	7	4.9	CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206673	76389	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	487	9	3	7	4.9	CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	156017532	177334	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645072	177334	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11605822	123869	1	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	503	9	1	6	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363930	123869	1	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	503	9	1	6	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1	10.1016/j.bmcl.2004.06.060
	162651761	179629	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting methodDisplacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting method	ChEMBL	798	19	7	8	3.0	NCCCC[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)C(N)=O	10.1016/j.ejmech.2016.07.078
	CHEMBL4749698	179629	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting methodDisplacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting method	ChEMBL	798	19	7	8	3.0	NCCCC[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)C(N)=O	10.1016/j.ejmech.2016.07.078
	70686292	75527	0	None	-	1	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	461	5	0	8	3.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048819	75527	0	None	-	1	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	461	5	0	8	3.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	10186158	97990	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	CHEMBL275660	97990	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	122178602	120824	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581035	120824	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL500468	212344	0	None	-	1	Human	6.6	pIC50	=	6.6	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm8014519
	CHEMBL3586019	210054	4	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1016/j.bmcl.2015.04.040
	122180025	121072	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	542	7	2	8	3.6	CC(=O)N1CC=C(c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)CC1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586031	121072	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	542	7	2	8	3.6	CC(=O)N1CC=C(c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)CC1	10.1016/j.bmcl.2015.04.040
	156017532	177334	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645072	177334	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145952740	161951	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4167481	161951	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	145974293	162474	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175823	162474	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44436881	91156	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	540	10	4	6	4.6	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1cccs1)C1CCNCC1	10.1021/jm0704550
	CHEMBL240746	91156	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	540	10	4	6	4.6	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1cccs1)C1CCNCC1	10.1021/jm0704550
	122182189	121494	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593814	121494	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	122180016	121063	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	540	9	2	9	5.1	CCCn1cc(-c2cnc(NCc3ccc4ncsc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586022	121063	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	540	9	2	9	5.1	CCCn1cc(-c2cnc(NCc3ccc4ncsc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	46882199	5684	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	438	7	4	4	4.4	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078498	5684	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	438	7	4	4	4.4	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44301462	11157	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179075	11157	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL58758	11157	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	90666042	108837	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	550	8	0	9	4.4	Cc1ncccc1-c1nc2cn(-c3cccc(OC(F)F)c3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
	CHEMBL3218915	108837	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	550	8	0	9	4.4	Cc1ncccc1-c1nc2cn(-c3cccc(OC(F)F)c3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
	25262771	112965	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	480	7	3	7	3.7	CC(C)NCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319280	112965	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	480	7	3	7	3.7	CC(C)NCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	42624370	188250	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1797	64	25	24	-7.0	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	44582537	188250	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1797	64	25	24	-7.0	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	91935104	188250	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1797	64	25	24	-7.0	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	CHEMBL506624	188250	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1797	64	25	24	-7.0	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	44445617	154138	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL399649	154138	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	11163070	65237	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	322	5	1	2	4.3	CCN(CC)c1ccc(NC(=O)C2CCc3ccccc3C2)cc1	10.1021/jm0491750
	CHEMBL183123	65237	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	322	5	1	2	4.3	CCN(CC)c1ccc(NC(=O)C2CCc3ccccc3C2)cc1	10.1021/jm0491750
	156012428	176736	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@H](C)C1	10.1016/j.bmcl.2020.126953
	CHEMBL4636832	176736	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@H](C)C1	10.1016/j.bmcl.2020.126953
	46882766	5596	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	11	4	4	3.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1077839	5596	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	11	4	4	3.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44436813	146774	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	11	4	5	4.5	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](C)N)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL392902	146774	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	11	4	5	4.5	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](C)N)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44410013	76700	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	10	3	7	4.5	CCCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207268	76700	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	10	3	7	4.5	CCCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44235473	81205	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163478	81205	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	44235473	81205	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163478	81205	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44409839	75905	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	412	7	4	8	2.0	CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205847	75905	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	412	7	4	8	2.0	CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16114099	136700	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	10	4	5	5.5	Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL375103	136700	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	10	4	5	5.5	Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	16113372	78744	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCN2)cc1	10.1021/jm0704550
	CHEMBL2113319	78744	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCN2)cc1	10.1021/jm0704550
	46882273	5741	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	494	10	4	4	5.8	CCCCc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078982	5741	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	494	10	4	4	5.8	CCCCc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	122182044	121485	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	552	9	2	6	4.9	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL3593633	121485	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	552	9	2	6	4.9	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	121879	2204	19	None	-	1	Human	5.6	pIC50	=	5.6	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	5868	2204	19	None	-	1	Human	5.6	pIC50	=	5.6	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	CHEMBL308716	2204	19	None	-	1	Human	5.6	pIC50	=	5.6	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	CHEMBL2370788	208176	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL		None	None	None		Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm020985q
	145950261	162179	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171137	162179	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44394974	66677	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	515	9	1	5	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL186974	66677	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	515	9	1	5	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1	10.1016/j.bmcl.2004.06.060
	44445615	161320	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL414929	161320	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	16113370	78749	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCCN2)cc1	10.1021/jm0704550
	CHEMBL2113323	78749	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCCN2)cc1	10.1021/jm0704550
	145953016	162037	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4168863	162037	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	156012445	176761	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637284	176761	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	10186158	97990	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	CHEMBL275660	97990	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	11617435	75644	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	359	5	3	6	4.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2csc(Cl)c2)cc1	10.1021/jm0510934
	CHEMBL205486	75644	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	359	5	3	6	4.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2csc(Cl)c2)cc1	10.1021/jm0510934
	70696689	75529	0	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	460	5	0	7	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5cccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048821	75529	0	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	460	5	0	7	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5cccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	70694647	75515	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	380	6	0	4	3.2	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048808	75515	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	380	6	0	4	3.2	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	56942242	124675	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	nan
	CHEMBL3645257	124675	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	nan
	122178605	120827	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581038	120827	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	44445611	154137	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL399648	154137	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	122182189	121494	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593814	121494	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	56942385	124678	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	nan
	CHEMBL3645260	124678	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	nan
	CHEMBL501261	212364	19	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O	10.1074/jbc.m609796200
	56942099	124674	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
	CHEMBL3645256	124674	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
	56942243	124676	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	nan
	CHEMBL3645258	124676	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	nan
	122178608	120831	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581041	120831	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	44409673	76397	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	493	9	3	9	3.9	Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)o1	10.1016/j.bmcl.2006.01.012
	CHEMBL206741	76397	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	493	9	3	9	3.9	Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)o1	10.1016/j.bmcl.2006.01.012
	CHEMBL105462	206726	34	None	-	1	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	11690097	76319	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	411	6	2	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL206446	76319	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	411	6	2	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	57422695	112977	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	574	10	2	9	4.6	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccn4)ccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319401	112977	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	574	10	2	9	4.6	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccn4)ccc3Cl)sc2c1	10.1021/jm500610n
	25124566	1844	6	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	10.1021/jm5003183
	5870	1844	6	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	10.1021/jm5003183
	CHEMBL3358452	1844	6	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	10.1021/jm5003183
	156013219	176915	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639379	176915	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145957574	161751	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164328	161751	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	46882805	5747	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	474	13	4	4	5.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NCC)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079046	5747	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	474	13	4	4	5.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NCC)cc2)cc1	10.1016/j.bmcl.2009.08.076
	53390538	91845	0	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426681	91845	0	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	178024	1940	30	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(99)00584-3
	5867	1940	30	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(99)00584-3
	CHEMBL13817	1940	30	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(99)00584-3
	44445629	161351	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	559	10	2	8	4.9	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL415136	161351	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	559	10	2	8	4.9	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	16204239	135761	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	CHEMBL373393	135761	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	11508639	76182	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	CHEMBL206091	76182	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	216208	9635	27	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL113313	9635	27	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1016/s0960-894x(99)00584-3
	11846630	138406	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	426	7	3	7	3.7	Nc1nc(N)c(-c2ccc(NC(=O)c3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL378438	138406	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	426	7	3	7	3.7	Nc1nc(N)c(-c2ccc(NC(=O)c3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	156012445	176761	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637284	176761	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145953016	162037	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4168863	162037	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	145949755	162384	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174302	162384	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	16204241	84007	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	11	3	5	4.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1CCc1ccccc1	10.1021/jm070024h
	CHEMBL221996	84007	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	11	3	5	4.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1CCc1ccccc1	10.1021/jm070024h
	11221946	140315	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	CHEMBL381942	140315	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	11221946	140315	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm060461g
	CHEMBL381942	140315	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm060461g
	46882104	5878	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.9	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079873	5878	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.9	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	145956415	161514	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160541	161514	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145950261	162179	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171137	162179	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	11654867	75848	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	429	7	3	5	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205833	75848	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	429	7	3	5	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1	10.1021/jm0510934
	10415364	126246	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL365294	126246	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	178024	1940	30	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
	5867	1940	30	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
	CHEMBL13817	1940	30	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
	16114404	154358	18	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL400814	154358	18	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1016/j.bmcl.2014.11.031
	90666014	108809	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	466	5	0	7	4.6	Cc1ccccc1-c1nc2cn(-c3cccc(C#N)c3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL3218887	108809	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	466	5	0	7	4.6	Cc1ccccc1-c1nc2cn(-c3cccc(C#N)c3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	44436885	145896	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	634	12	6	8	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)c(OC)c1	10.1021/jm0704550
	CHEMBL392191	145896	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	634	12	6	8	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)c(OC)c1	10.1021/jm0704550
	44436829	151946	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	11	4	6	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL397109	151946	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	11	4	6	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	16114404	154358	18	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
	CHEMBL400814	154358	18	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
	122182047	121488	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593636	121488	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	70684155	75532	0	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	486	5	0	6	4.1	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-c3ncccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	CHEMBL2048824	75532	0	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	486	5	0	6	4.1	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-c3ncccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	CHEMBL2163483	207580	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163483	207580	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44409872	74716	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	7	2	8	3.1	CCc1nc(N)nc(N2CCOCC2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203581	74716	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	7	2	8	3.1	CCc1nc(N)nc(N2CCOCC2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44445596	154106	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	558	10	2	7	5.5	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL399448	154106	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	558	10	2	7	5.5	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	16113692	136712	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	11	4	5	5.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	CHEMBL375162	136712	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	11	4	5	5.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	118709504	112980	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	572	5	2	9	4.3	Cc1ccnn1-c1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	CHEMBL3319404	112980	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	572	5	2	9	4.3	Cc1ccnn1-c1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	10907396	98693	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	515	10	7	5	1.2	NC1(C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)NC=O)CCNCC1	10.1021/jm020985q
	CHEMBL281147	98693	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	515	10	7	5	1.2	NC1(C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)NC=O)CCNCC1	10.1021/jm020985q
	11677781	124538	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	502	9	1	5	5.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL364430	124538	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	502	9	1	5	5.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1	10.1016/j.bmcl.2004.06.060
	44445606	154475	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	625	12	3	7	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL401467	154475	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	625	12	3	7	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	44379034	12815	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	490	9	2	5	5.1	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1189120	12815	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	490	9	2	5	5.1	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL538068	12815	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	490	9	2	5	5.1	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	44378986	12984	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	470	10	2	5	3.2	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1190325	12984	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	470	10	2	5	3.2	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL540603	12984	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	470	10	2	5	3.2	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	11697618	62270	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	427	6	1	4	5.5	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178289	62270	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	427	6	1	4	5.5	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	145956415	161514	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160541	161514	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44436886	161406	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	595	12	5	8	3.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL415674	161406	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	595	12	5	8	3.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	145949755	162384	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174302	162384	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	23648242	78746	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.7	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1021/jm0704550
	CHEMBL2113320	78746	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.7	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1021/jm0704550
	11606121	64245	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	523	6	2	6	5.9	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.11.075
	CHEMBL181584	64245	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	523	6	2	6	5.9	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.11.075
	122180023	121070	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	530	7	2	8	3.8	C[C@H]1CN(c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)C[C@@H](C)O1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586029	121070	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	530	7	2	8	3.8	C[C@H]1CN(c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)C[C@@H](C)O1	10.1016/j.bmcl.2015.04.040
	44379301	12949	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	7	3.7	COC(=O)C(CCCCN)NC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Cl)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1190091	12949	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	7	3.7	COC(=O)C(CCCCN)NC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Cl)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL540093	12949	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	7	3.7	COC(=O)C(CCCCN)NC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Cl)cc2c1=O	10.1016/s0960-894x(99)00584-3
	44338300	167280	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	525	10	1	6	4.0	CN(C)CCCN1C(=O)[C@H](Cc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
	CHEMBL430882	167280	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	525	10	1	6	4.0	CN(C)CCCN1C(=O)[C@H](Cc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
	44338239	167335	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	511	9	1	6	4.2	CN(C)CCCN1C(=O)[C@H](c2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
	CHEMBL431245	167335	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	511	9	1	6	4.2	CN(C)CCCN1C(=O)[C@H](c2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
	44409762	75533	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	441	9	4	8	2.7	CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204884	75533	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	441	9	4	8	2.7	CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122180018	121065	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	527	9	2	9	4.3	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586024	121065	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	527	9	2	9	4.3	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	122182189	121494	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593814	121494	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	10032659	11946	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL1183505	11946	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL301259	11946	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	60195019	81192	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	849	21	10	8	2.2	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163464	81192	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	849	21	10	8	2.2	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	156009875	176549	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633695	176549	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11430583	79807	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	439	8	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL213704	79807	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	439	8	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	11517629	167775	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	431	6	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL434330	167775	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	431	6	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1	10.1016/j.bmcl.2004.11.075
	44409975	75438	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	411	7	3	7	3.3	CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204835	75438	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	411	7	3	7	3.3	CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	53391301	91842	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426678	91842	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	90666019	108814	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	464	7	0	8	3.8	COCCN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(C4CCCCC4)nc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218892	108814	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	464	7	0	8	3.8	COCCN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(C4CCCCC4)nc3c2=O)C1	10.1039/C2MD20340E
	11669486	64283	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	445	7	1	4	6.6	CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	CHEMBL181736	64283	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	445	7	1	4	6.6	CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	59446141	81208	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163481	81208	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	59446141	81208	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163481	81208	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44436917	90218	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	4	5	5.3	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL239007	90218	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	4	5	5.3	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	60165265	115698	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	453	5	1	2	6.0	CC(NC(=O)N(Cc1ccccc1Cl)C1CCN(C)CC1)c1cccc(Cl)c1Cl	10.1021/jm5003183
	CHEMBL3358453	115698	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	453	5	1	2	6.0	CC(NC(=O)N(Cc1ccccc1Cl)C1CCN(C)CC1)c1cccc(Cl)c1Cl	10.1021/jm5003183
	16113002	147781	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	577	12	4	7	4.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)c(OC)c1	10.1021/jm0704550
	CHEMBL393693	147781	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	577	12	4	7	4.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)c(OC)c1	10.1021/jm0704550
	44409678	140686	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	490	9	3	9	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL382853	140686	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	490	9	3	9	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122178604	120826	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581037	120826	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	10929048	68465	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	488	9	6	4	2.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL19220	68465	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	488	9	6	4	2.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	60195018	81191	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	9	7	3.2	CCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NN(CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163463	81191	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	9	7	3.2	CCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NN(CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44394913	126652	1	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	537	10	1	5	7.5	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccccc2OC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL365721	126652	1	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	537	10	1	5	7.5	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccccc2OC)cc1	10.1016/j.bmcl.2004.06.060
	11649248	66337	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	515	9	1	5	7.2	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185399	66337	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	515	9	1	5	7.2	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	44394833	126304	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	542	9	1	5	6.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL365460	126304	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	542	9	1	5	6.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1	10.1016/j.bmcl.2004.06.060
	11827047	98763	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	488	11	6	4	2.1	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O	10.1021/jm020985q
	CHEMBL281578	98763	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	488	11	6	4	2.1	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O	10.1021/jm020985q
	42624359	192798	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1755	61	25	24	-8.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	44582536	192798	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1755	61	25	24	-8.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	91935103	192798	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1755	61	25	24	-8.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	CHEMBL525751	192798	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1755	61	25	24	-8.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	156009875	176549	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633695	176549	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156021942	177649	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649860	177649	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	122180021	121068	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	528	7	2	7	4.9	O=C(NCC1COc2ccccc2O1)c1cc(-c2ccnc(Cl)c2)cnc1NCc1ccc2c(c1)OCC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586027	121068	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	528	7	2	7	4.9	O=C(NCC1COc2ccccc2O1)c1cc(-c2ccnc(Cl)c2)cnc1NCc1ccc2c(c1)OCC2	10.1016/j.bmcl.2015.04.040
	11134880	98972	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	500	10	6	4	2.1	O=CN[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
	CHEMBL282891	98972	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	500	10	6	4	2.1	O=CN[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
	11846629	138290	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	419	7	3	7	3.1	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCO3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL378118	138290	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	419	7	3	7	3.1	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCO3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	11114279	97797	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	544	12	6	4	3.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1021/jm020985q
	CHEMBL274460	97797	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	544	12	6	4	3.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1021/jm020985q
	145952396	162453	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	CHEMBL4175534	162453	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	122178607	120830	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581040	120830	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	156013219	176915	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639379	176915	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145957574	161751	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164328	161751	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	11846463	138712	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	422	5	2	8	2.7	CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL378909	138712	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	422	5	2	8	2.7	CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	9890863	131470	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)C(O)(c2ccccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL369533	131470	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)C(O)(c2ccccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	44409864	75148	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	502	9	3	8	4.0	CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204266	75148	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	502	9	3	8	4.0	CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122180027	121074	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	566	8	2	7	5.2	CC(C)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586033	121074	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	566	8	2	7	5.2	CC(C)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	11430392	76371	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	431	6	3	7	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1	10.1021/jm0510934
	CHEMBL206588	76371	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	431	6	3	7	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1	10.1021/jm0510934
	57785737	112943	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	549	7	2	8	3.7	CN1CCCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319216	112943	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	549	7	2	8	3.7	CN1CCCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	44390871	64511	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2c(Cl)cccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL182035	64511	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2c(Cl)cccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	70682037	75528	14	None	43	2	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048820	75528	14	None	43	2	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	156021297	177515	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647797	177515	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	90666040	108835	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	542	9	0	9	4.6	CCCOc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218913	108835	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	542	9	0	9	4.6	CCCOc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	90666026	108821	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	516	9	0	9	4.1	CCO[C@H](C)CN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218899	108821	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	516	9	0	9	4.1	CCO[C@H](C)CN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	16204021	84283	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	10	3	5	4.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(F)cc1	10.1021/jm070024h
	CHEMBL222710	84283	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	10	3	5	4.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(F)cc1	10.1021/jm070024h
	122180014	121061	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	539	9	2	8	5.8	CCCn1cc(-c2cnc(NCc3ccc4sccc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586020	121061	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	539	9	2	8	5.8	CCCn1cc(-c2cnc(NCc3ccc4sccc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	90666016	108811	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	481	5	0	9	2.9	Cc1ncccc1-c1nc2cn(-c3ccc(C#N)cc3)nc2c(=O)n1CC1CCCN(C2COC2)C1	10.1039/C2MD20340E
	CHEMBL3218889	108811	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	481	5	0	9	2.9	Cc1ncccc1-c1nc2cn(-c3ccc(C#N)cc3)nc2c(=O)n1CC1CCCN(C2COC2)C1	10.1039/C2MD20340E
	44389186	64284	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	379	7	1	5	4.8	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL181739	64284	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	379	7	1	5	4.8	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44338266	109844	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	523	11	1	6	4.3	CN(C)CCCN1C(=O)[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O	10.1016/j.bmcl.2003.11.012
	CHEMBL323974	109844	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	523	11	1	6	4.3	CN(C)CCCN1C(=O)[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O	10.1016/j.bmcl.2003.11.012
	70692602	75523	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	423	8	0	5	3.5	CCCOc1ccc(CN2CC3(CCN(C(=O)Cc4ccc(OC)cc4)CC3)C2)cn1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048815	75523	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	423	8	0	5	3.5	CCCOc1ccc(CN2CC3(CCN(C(=O)Cc4ccc(OC)cc4)CC3)C2)cn1	10.1016/j.bmcl.2012.05.024
	11455251	160767	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	523	8	3	7	5.0	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL412362	160767	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	523	8	3	7	5.0	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	156021942	177649	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649860	177649	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	16204037	136709	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccccc1Cn1c(Cc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL375150	136709	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccccc1Cn1c(Cc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	11582836	62584	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	431	7	1	4	6.4	CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178463	62584	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	431	7	1	4	6.4	CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44389131	63132	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	485	6	1	4	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C(F)(F)F)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL179812	63132	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	485	6	1	4	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C(F)(F)F)c1	10.1016/j.bmcl.2004.11.075
	122180025	121072	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	542	7	2	8	3.6	CC(=O)N1CC=C(c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)CC1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586031	121072	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	542	7	2	8	3.6	CC(=O)N1CC=C(c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)CC1	10.1016/j.bmcl.2015.04.040
	122178612	120835	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581045	120835	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	16203237	96503	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	496	10	3	6	4.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1	10.1021/jm070024h
	CHEMBL266199	96503	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	496	10	3	6	4.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1	10.1021/jm070024h
	44582531	188136	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL	3368	117	49	47	-15.3	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm8014519
	91935100	188136	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL	3368	117	49	47	-15.3	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm8014519
	CHEMBL504776	188136	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL	3368	117	49	47	-15.3	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm8014519
	59446148	174477	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	840	21	10	9	1.3	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CC1CCCCC1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL4567800	174477	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	840	21	10	9	1.3	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CC1CCCCC1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	46882152	5778	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	12	4	4	4.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(CCCN)c2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079302	5778	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	12	4	4	4.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(CCCN)c2)cc1	10.1016/j.bmcl.2009.08.076
	11655355	74072	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL202642	74072	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	145952396	162453	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	CHEMBL4175534	162453	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	46882764	5555	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	375	9	3	3	4.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1077716	5555	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	375	9	3	3	4.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1	10.1016/j.bmcl.2009.08.076
	16114290	136684	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	534	11	3	5	5.3	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL374992	136684	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	534	11	3	5	5.3	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	90666015	108810	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	483	7	0	9	3.2	COCCN1CCCC(Cn2c(-c3cccnc3C)nc3cn(-c4ccc(C#N)cc4)nc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218888	108810	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	483	7	0	9	3.2	COCCN1CCCC(Cn2c(-c3cccnc3C)nc3cn(-c4ccc(C#N)cc4)nc3c2=O)C1	10.1039/C2MD20340E
	44436831	151464	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	580	12	4	7	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL396681	151464	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	580	12	4	7	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	25262608	112964	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	492	6	2	7	3.8	O=C(NC(=O)c1ccccc1Cl)Nc1nc2ccc(S(=O)(=O)CCN3CCCC3)cc2s1	10.1021/jm500610n
	CHEMBL3319279	112964	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	492	6	2	7	3.8	O=C(NC(=O)c1ccccc1Cl)Nc1nc2ccc(S(=O)(=O)CCN3CCCC3)cc2s1	10.1021/jm500610n
	10918326	98515	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N(C)C	10.1021/jm020985q
	CHEMBL279822	98515	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N(C)C	10.1021/jm020985q
	16203918	84363	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	570	9	3	5	5.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccc(Br)cc1	10.1021/jm070024h
	CHEMBL223239	84363	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	570	9	3	5	5.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccc(Br)cc1	10.1021/jm070024h
	70696687	75520	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	446	7	0	6	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4cccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048812	75520	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	446	7	0	6	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4cccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	46882105	6274	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)CN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1082044	6274	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)CN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44446189	154835	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL403426	154835	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	44446157	94215	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	594	13	3	8	4.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](CC(=O)OCc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252501	94215	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	594	13	3	8	4.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](CC(=O)OCc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	44446148	154879	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL403683	154879	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	44410008	140720	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	9	2	7	4.2	CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383058	140720	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	9	2	7	4.2	CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	59446143	81188	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	802	17	11	8	0.6	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	nan
	CHEMBL2163448	81188	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	802	17	11	8	0.6	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	nan
	59446143	81188	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	802	17	11	8	0.6	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
	CHEMBL2163448	81188	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	802	17	11	8	0.6	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
	44338221	7966	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	581	11	1	7	4.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=S)N1CCCN1CCOCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL109094	7966	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	581	11	1	7	4.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=S)N1CCCN1CCOCC1	10.1016/j.bmcl.2003.11.012
	60195113	81195	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	787	17	9	7	2.5	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/jm300557t
	CHEMBL2163467	81195	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	787	17	9	7	2.5	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/jm300557t
	46882804	5746	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	446	11	4	4	4.5	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079045	5746	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	446	11	4	4	4.5	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	10864048	97936	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.6	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL275373	97936	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.6	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	156016110	177124	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	628	7	1	9	5.1	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccc(S(=O)(=O)C5CCN(C)CC5)cc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	CHEMBL4642043	177124	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	628	7	1	9	5.1	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccc(S(=O)(=O)C5CCN(C)CC5)cc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	156017268	177076	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641472	177076	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	59446118	174128	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)N(Cc1cccc2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL4559602	174128	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)N(Cc1cccc2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	60195285	81200	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)N(Cc1cccc2ccccc12)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163473	81200	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)N(Cc1cccc2ccccc12)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44436868	145550	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	9	4	5	4.6	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1c1ccccc1)C1CCNCC1	10.1021/jm0704550
	CHEMBL391922	145550	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	9	4	5	4.6	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1c1ccccc1)C1CCNCC1	10.1021/jm0704550
	44394947	168657	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL440939	168657	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)cc1	10.1016/j.bmcl.2004.06.060
	122180022	121069	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	504	7	2	9	2.8	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2CCOCC2)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586028	121069	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	504	7	2	9	2.8	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2CCOCC2)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	11751384	140974	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	453	9	3	6	4.6	Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL384524	140974	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	453	9	3	6	4.6	Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	122180026	121073	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586032	121073	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	122182043	121484	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL3593632	121484	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	16204226	84375	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	486	12	3	5	5.1	CCCCCCn1c(Cc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL223323	84375	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	486	12	3	5	5.1	CCCCCCn1c(Cc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	118709472	112963	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	409	3	2	6	3.3	CS(=O)(=O)c1ccc2sc(NC(=O)NC(=O)c3ccccc3Cl)nc2c1	10.1021/jm500610n
	CHEMBL3319277	112963	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	409	3	2	6	3.3	CS(=O)(=O)c1ccc2sc(NC(=O)NC(=O)c3ccccc3Cl)nc2c1	10.1021/jm500610n
	46882196	5664	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	9	4	4	3.7	CCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078402	5664	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	9	4	4	3.7	CCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44379303	12730	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	468	11	2	5	4.1	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1188529	12730	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	468	11	2	5	4.1	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL536706	12730	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	468	11	2	5	4.1	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL2310893	207751	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
	44445614	168743	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	554	11	2	5	6.0	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL441567	168743	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	554	11	2	5	6.0	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	44445598	93940	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	565	9	3	5	6.5	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL250807	93940	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	565	9	3	5	6.5	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	145949381	162165	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170865	162165	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	44436832	151466	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	548	11	4	5	4.9	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL396682	151466	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	548	11	4	5	4.9	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44445626	96619	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	573	11	2	8	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL267197	96619	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	573	11	2	8	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	90666025	108820	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	516	9	0	9	4.1	CCO[C@@H](C)CN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218898	108820	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	516	9	0	9	4.1	CCO[C@@H](C)CN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	156012122	176807	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637980	176807	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156012122	176807	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637980	176807	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156021297	177515	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647797	177515	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	90666024	108819	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218897	108819	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	57422776	112945	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	559	7	2	8	3.3	C#Cc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	CHEMBL3319218	112945	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	559	7	2	8	3.3	C#Cc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	162657463	180458	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting methodDisplacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting method	ChEMBL	783	20	7	7	4.0	NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)C(N)=O	10.1016/j.ejmech.2016.07.078
	CHEMBL4759415	180458	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting methodDisplacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting method	ChEMBL	783	20	7	7	4.0	NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)C(N)=O	10.1016/j.ejmech.2016.07.078
	44409990	76164	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	481	12	3	7	5.2	CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205995	76164	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	481	12	3	7	5.2	CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122180024	121071	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	530	7	2	9	3.4	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2C[C@@H]3CC[C@H](C2)O3)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586030	121071	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	530	7	2	9	3.4	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2C[C@@H]3CC[C@H](C2)O3)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	44409758	75621	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	411	6	3	7	3.4	CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205374	75621	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	411	6	3	7	3.4	CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122182190	121495	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	CHEMBL3593815	121495	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	44409684	140354	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	474	8	4	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL382033	140354	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	474	8	4	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16113003	94309	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	617	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)c(OC)c1	10.1021/jm701292s
	CHEMBL253126	94309	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	617	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)c(OC)c1	10.1021/jm701292s
	16113003	94309	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	617	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)c(OC)c1	10.1021/jm0704550
	CHEMBL253126	94309	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	617	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)c(OC)c1	10.1021/jm0704550
	122182047	121488	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593636	121488	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	90666030	108825	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	486	7	0	8	4.3	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218903	108825	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	486	7	0	8	4.3	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	11605333	76372	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	475	6	3	7	3.6	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1	10.1021/jm0510934
	CHEMBL206589	76372	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	475	6	3	7	3.6	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1	10.1021/jm0510934
	122182046	121487	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593635	121487	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
	11281346	75665	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	411	8	3	6	4.6	Nc1nc(N)c(-c2ccc(NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205568	75665	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	411	8	3	6	4.6	Nc1nc(N)c(-c2ccc(NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	145949381	162165	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170865	162165	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	16204145	136029	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	492	9	3	5	4.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccccc1	10.1021/jm070024h
	CHEMBL373772	136029	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	492	9	3	5	4.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccccc1	10.1021/jm070024h
	90666036	108831	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	479	8	0	8	3.7	COc1cccc(-n2cc3nc(CC(C)C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218909	108831	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	479	8	0	8	3.7	COc1cccc(-n2cc3nc(CC(C)C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	44338235	109174	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	546	7	3	6	4.1	O=C1[C@H](Cc2c[nH]c3ccccc23)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1C1CCNCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL322499	109174	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	546	7	3	6	4.1	O=C1[C@H](Cc2c[nH]c3ccccc23)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1C1CCNCC1	10.1016/j.bmcl.2003.11.012
	156016392	177072	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641386	177072	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156017268	177076	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641472	177076	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145958317	161763	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164531	161763	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145949880	162241	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172217	162241	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	145950963	162256	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172411	162256	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	156016392	177072	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641386	177072	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44445608	154476	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	554	11	2	5	6.0	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL401468	154476	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	554	11	2	5	6.0	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	59446116	81186	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	777	17	9	8	0.8	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)N(Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
	CHEMBL2163439	81186	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	777	17	9	8	0.8	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)N(Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
	23631387	92834	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	409	4	0	4	5.1	Cc1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL244936	92834	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	409	4	0	4	5.1	Cc1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1039/C2MD20340E
	90666038	108833	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1ccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)cc1	10.1039/C2MD20340E
	CHEMBL3218911	108833	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1ccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)cc1	10.1039/C2MD20340E
	44421230	84367	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	546	8	3	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1-c1ccc(Cl)c(Cl)c1	10.1021/jm070024h
	CHEMBL223269	84367	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	546	8	3	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1-c1ccc(Cl)c(Cl)c1	10.1021/jm070024h
	156018460	177303	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	468	5	1	7	4.6	CCOc1cc(Cl)c(-c2ncc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	CHEMBL4644587	177303	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	468	5	1	7	4.6	CCOc1cc(Cl)c(-c2ncc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	145950963	162256	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172411	162256	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	11618705	166385	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	423	6	1	4	5.3	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL428698	166385	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	423	6	1	4	5.3	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1	10.1016/j.bmcl.2004.06.060
	44436842	146405	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCCN2)cc1	10.1021/jm0704550
	CHEMBL392592	146405	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCCN2)cc1	10.1021/jm0704550
	CHEMBL509976	213804	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	CHEMBL450217	212213	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in COS-7 cells incubated for 3 hrsDisplacement of [35S]MK677 from human ghrelin receptor expressed in COS-7 cells incubated for 3 hrs	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm300414b
	CHEMBL450217	212213	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12)C(N)=O	10.1074/jbc.m609796200
	10984270	98055	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	530	11	6	4	3.3	CC(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL276137	98055	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	530	11	6	4	3.3	CC(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	44436884	91121	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	565	11	5	7	3.1	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL240522	91121	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	565	11	5	7	3.1	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL444131	212181	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		NC(=O)CNC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12	10.1074/jbc.m609796200
	60195020	81193	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	835	21	10	8	1.8	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163465	81193	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	835	21	10	8	1.8	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	59446112	172405	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	840	21	10	9	1.3	C[C@H](NC(=O)N(CC1CCCCC1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL4517723	172405	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	840	21	10	9	1.3	C[C@H](NC(=O)N(CC1CCCCC1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL422461	211538	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O	10.1021/jm0001727
	16114010	135760	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	613	10	4	5	6.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(Cl)c(Cl)c1	10.1021/jm070024h
	CHEMBL373392	135760	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	613	10	4	5	6.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(Cl)c(Cl)c1	10.1021/jm070024h
	16203349	165737	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	4.9	COc1ccc(CCn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL427076	165737	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	4.9	COc1ccc(CCn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	11531313	62175	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	394	7	1	6	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178137	62175	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	394	7	1	6	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44389283	62616	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	403	5	1	4	5.7	CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178494	62616	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	403	5	1	4	5.7	CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	122180019	121066	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586025	121066	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL447282	212200	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL		None	None	None		CCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O	10.1021/jm8014519
	145958317	161763	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164531	161763	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	16114008	84422	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL223532	84422	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	16112910	135854	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	CHEMBL373507	135854	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	16112910	135854	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL373507	135854	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	44436882	145483	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	10	4	6	4.2	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1	10.1021/jm0704550
	CHEMBL391859	145483	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	10	4	6	4.2	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1	10.1021/jm0704550
	145949880	162241	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172217	162241	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	122180024	121071	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	530	7	2	9	3.4	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2C[C@@H]3CC[C@H](C2)O3)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586030	121071	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	530	7	2	9	3.4	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2C[C@@H]3CC[C@H](C2)O3)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	46882154	5784	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	390	7	4	4	2.9	CCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079323	5784	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	390	7	4	4	2.9	CCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	59446145	81187	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	793	19	11	8	0.8	C[C@H](N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163444	81187	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	793	19	11	8	0.8	C[C@H](N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	59446145	81187	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	793	19	11	8	0.8	C[C@H](N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163444	81187	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	793	19	11	8	0.8	C[C@H](N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	11699004	65871	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	501	9	1	5	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL184429	65871	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	501	9	1	5	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1	10.1016/j.bmcl.2004.06.060
	11537800	75216	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	361	6	3	6	3.7	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL204564	75216	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	361	6	3	6	3.7	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1	10.1021/jm0510934
	16203236	165709	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	512	10	3	6	4.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1cccs1	10.1021/jm070024h
	CHEMBL426905	165709	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	512	10	3	6	4.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1cccs1	10.1021/jm070024h
	10207327	66736	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	CHEMBL18725	66736	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	44445603	154441	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccncc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL401259	154441	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccncc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL502208	212379	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1074/jbc.m609796200
	16113583	161202	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	469	8	4	5	3.7	Cn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL413856	161202	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	469	8	4	5	3.7	Cn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	90665849	108788	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	508	7	0	7	5.5	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3nc(-c4ccc(Cl)cc4)sc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218649	108788	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	508	7	0	7	5.5	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3nc(-c4ccc(Cl)cc4)sc3c2=O)C1	10.1039/C2MD20340E
	70696688	75526	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	487	9	0	6	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cn1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048818	75526	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	487	9	0	6	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cn1	10.1016/j.bmcl.2012.05.024
	44436816	91373	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	12	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL241242	91373	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	12	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	10984270	98055	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	530	11	6	4	3.3	CC(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL276137	98055	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	530	11	6	4	3.3	CC(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	44301387	11159	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179088	11159	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL59572	11159	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	11692087	62663	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL178610	62663	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	122178610	120833	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581043	120833	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	16113695	136503	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm701292s
	CHEMBL374643	136503	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm701292s
	16113695	136503	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL374643	136503	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	16113695	136503	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL374643	136503	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	16113695	136503	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm0704550
	CHEMBL374643	136503	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm0704550
	44436888	152522	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	565	11	3	6	5.0	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCOCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL397593	152522	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	565	11	3	6	5.0	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCOCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	11692087	62663	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178610	62663	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.11.075
	44409809	74715	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	10	3	7	4.4	CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203578	74715	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	10	3	7	4.4	CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409989	165273	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	11	3	7	4.8	CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL424860	165273	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	11	3	7	4.8	CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL105462	206726	34	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	90666018	108813	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	488	8	0	9	3.3	COCCN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218891	108813	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	488	8	0	9	3.3	COCCN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	11612155	140478	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL382375	140478	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	118722878	115697	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	494	5	2	4	4.8	CN1CCN([C@@H](C(=O)NNc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2Cl)CC1	10.1021/jm5003183
	CHEMBL3358451	115697	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	494	5	2	4	4.8	CN1CCN([C@@H](C(=O)NNc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2Cl)CC1	10.1021/jm5003183
	16114097	78747	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1	10.1021/jm0704550
	CHEMBL2113321	78747	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1	10.1021/jm0704550
	122182189	121494	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593814	121494	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	25260901	112981	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	577	5	2	9	3.6	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319405	112981	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	577	5	2	9	3.6	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	122180021	121068	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	528	7	2	7	4.9	O=C(NCC1COc2ccccc2O1)c1cc(-c2ccnc(Cl)c2)cnc1NCc1ccc2c(c1)OCC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586027	121068	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	528	7	2	7	4.9	O=C(NCC1COc2ccccc2O1)c1cc(-c2ccnc(Cl)c2)cnc1NCc1ccc2c(c1)OCC2	10.1016/j.bmcl.2015.04.040
	11179347	77000	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	490	9	2	8	4.0	CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL208477	77000	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	490	9	2	8	4.0	CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	44445593	154249	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL400174	154249	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	16203569	141201	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	CHEMBL385803	141201	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	90666034	108829	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.7	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCOC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218907	108829	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.7	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCOC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL449590	212212	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1074/jbc.m609796200
	121879	2204	19	None	-	1	Rat	7.2	pIC50	=	7.2	Binding	Inhibition against rat growth hormone secretagogue (GHS) receptorInhibition against rat growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	5868	2204	19	None	-	1	Rat	7.2	pIC50	=	7.2	Binding	Inhibition against rat growth hormone secretagogue (GHS) receptorInhibition against rat growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	CHEMBL308716	2204	19	None	-	1	Rat	7.2	pIC50	=	7.2	Binding	Inhibition against rat growth hormone secretagogue (GHS) receptorInhibition against rat growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	11568561	168987	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	447	7	1	5	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL443560	168987	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	447	7	1	5	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1	10.1016/j.bmcl.2004.11.075
	44338246	98398	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	563	11	1	6	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL278909	98398	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	563	11	1	6	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL105462	206726	34	None	-	1	Human	5.2	pIC50	=	5.2	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/s0960-894x(99)00584-3
	44409767	156700	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	437	8	3	7	3.9	CCc1nc(N)nc(NC2CC2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL407647	156700	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	437	8	3	7	3.9	CCc1nc(N)nc(NC2CC2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44445612	96593	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	565	10	3	5	5.9	O=C(Cc1ccccn1)N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm701292s
	CHEMBL266964	96593	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	565	10	3	5	5.9	O=C(Cc1ccccn1)N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm701292s
	44410003	75828	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	468	10	4	8	3.5	CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205794	75828	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	468	10	4	8	3.5	CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16203569	141201	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL385803	141201	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL18872	207314	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(C)(C)N)C(N)=O	10.1021/jm300557t
	46882106	5785	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	11	4	4	3.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(CCN)c2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079340	5785	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	11	4	4	3.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(CCN)c2)cc1	10.1016/j.bmcl.2009.08.076
	44436876	146486	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	580	11	4	7	4.6	COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL392663	146486	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	580	11	4	7	4.6	COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	121879	2204	19	None	-	1	Pig	7.2	pIC50	=	7.2	Binding	Inhibition against pig growth hormone secretagogue (GHS) receptorInhibition against pig growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	5868	2204	19	None	-	1	Pig	7.2	pIC50	=	7.2	Binding	Inhibition against pig growth hormone secretagogue (GHS) receptorInhibition against pig growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	CHEMBL308716	2204	19	None	-	1	Pig	7.2	pIC50	=	7.2	Binding	Inhibition against pig growth hormone secretagogue (GHS) receptorInhibition against pig growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	156010733	176506	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633062	176506	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145962494	161525	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160705	161525	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145950201	162392	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174476	162392	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	44409832	76057	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	398	6	4	8	1.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205955	76057	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	398	6	4	8	1.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16204237	84473	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	574	10	3	5	6.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(Cl)c(Cl)c1	10.1021/jm070024h
	CHEMBL223638	84473	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	574	10	3	5	6.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(Cl)c(Cl)c1	10.1021/jm070024h
	16204343	136667	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	635	12	4	5	7.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CC(c1ccccc1)c1ccccc1	10.1021/jm070024h
	CHEMBL374918	136667	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	635	12	4	5	7.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CC(c1ccccc1)c1ccccc1	10.1021/jm070024h
	122178613	120836	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581046	120836	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	57422749	112940	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	492	4	2	7	3.8	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319213	112940	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	492	4	2	7	3.8	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	44410007	76074	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	438	8	4	8	2.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205963	76074	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	438	8	4	8	2.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	118718706	114880	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL3350011	114880	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	89768546	148485	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of ghrelin receptor (unknown origin) by radioligand binding assayInhibition of ghrelin receptor (unknown origin) by radioligand binding assay	ChEMBL	438	4	2	5	5.5	Cc1nnc2sc(C(=O)NCc3ccc(S(F)(F)(F)(F)F)cc3)c(N)c2c1C	10.1016/j.bmcl.2016.11.086
	CHEMBL3942511	148485	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of ghrelin receptor (unknown origin) by radioligand binding assayInhibition of ghrelin receptor (unknown origin) by radioligand binding assay	ChEMBL	438	4	2	5	5.5	Cc1nnc2sc(C(=O)NCc3ccc(S(F)(F)(F)(F)F)cc3)c(N)c2c1C	10.1016/j.bmcl.2016.11.086
	16114011	137610	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	10	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1	10.1021/jm070024h
	CHEMBL376736	137610	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	10	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1	10.1021/jm070024h
	11349789	78363	1	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	389	7	3	6	3.4	Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL211265	78363	1	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	389	7	3	6	3.4	Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	16112909	143749	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	561	10	4	6	5.0	COc1ccc(Cn2c(Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL390503	143749	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	561	10	4	6	5.0	COc1ccc(Cn2c(Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	44378837	12911	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	484	11	2	5	3.6	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1189851	12911	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	484	11	2	5	3.6	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL539575	12911	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	484	11	2	5	3.6	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	44445597	94080	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	540	10	2	5	6.1	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL251640	94080	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	540	10	2	5	6.1	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	11176805	76981	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	391	7	3	6	4.5	CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm0510934
	CHEMBL208374	76981	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	391	7	3	6	4.5	CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm0510934
	156010733	176506	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633062	176506	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	46882153	5783	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	528	13	4	4	5.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NCC(F)(F)F)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079322	5783	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	528	13	4	4	5.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NCC(F)(F)F)cc2)cc1	10.1016/j.bmcl.2009.08.076
	145950201	162392	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174476	162392	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	46882239	5707	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1cccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)c1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078700	5707	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1cccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)c1	10.1016/j.bmcl.2009.08.076
	1221269	121520	12	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359530	121520	12	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44446177	94210	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252448	94210	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	16114289	98212	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL277376	98212	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1	10.1021/jm0704550
	11538533	74651	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm060461g
	CHEMBL203280	74651	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm060461g
	10415364	126246	0	None	-	0	Mouse	8.2	pIC50	=	8.2	Binding	Inhibitory concentration against mouse Growth hormone secretagogue receptorInhibitory concentration against mouse Growth hormone secretagogue receptor	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL365294	126246	0	None	-	0	Mouse	8.2	pIC50	=	8.2	Binding	Inhibitory concentration against mouse Growth hormone secretagogue receptorInhibitory concentration against mouse Growth hormone secretagogue receptor	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL263544	208830	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(N)=O	10.1021/jm0001727
	122180023	121070	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	530	7	2	8	3.8	C[C@H]1CN(c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)C[C@@H](C)O1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586029	121070	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	530	7	2	8	3.8	C[C@H]1CN(c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)C[C@@H](C)O1	10.1016/j.bmcl.2015.04.040
	118709507	112984	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	547	4	2	8	3.8	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc5c(cc4Cl)CCN5C)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319408	112984	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	547	4	2	8	3.8	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc5c(cc4Cl)CCN5C)sc3c2)CC1	10.1021/jm500610n
	90666011	108806	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	471	6	0	7	4.7	COc1ccc(-n2cc3nc(-c4ccccc4C)n(CC4CCCN(C(C)C)C4)c(=O)c3n2)cc1	10.1039/C2MD20340E
	CHEMBL3218884	108806	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	471	6	0	7	4.7	COc1ccc(-n2cc3nc(-c4ccccc4C)n(CC4CCCN(C(C)C)C4)c(=O)c3n2)cc1	10.1039/C2MD20340E
	11538533	74651	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL203280	74651	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	44409998	138007	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	413	7	3	8	2.5	COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL377515	138007	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	413	7	3	8	2.5	COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	90666021	108816	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218894	108816	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	11453509	75825	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	441	9	3	7	4.6	COc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205784	75825	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	441	9	3	7	4.6	COc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	44445610	161174	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	595	11	3	6	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL413608	161174	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	595	11	3	6	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	23648249	78752	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	557	9	4	5	5.4	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1	10.1021/jm0704550
	CHEMBL2113326	78752	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	557	9	4	5	5.4	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1	10.1021/jm0704550
	11178309	79491	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	445	8	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL212415	79491	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	445	8	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL3578018	210022	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	CHEMBL3578018	210022	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	44445613	93753	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	512	9	2	5	5.4	O=C(Cc1ccccn1)N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1-c1ccccc1	10.1021/jm701292s
	CHEMBL249662	93753	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	512	9	2	5	5.4	O=C(Cc1ccccn1)N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1-c1ccccc1	10.1021/jm701292s
	16204229	83900	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	CHEMBL221569	83900	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	44409867	76388	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	473	8	3	7	5.0	CCc1nc(N)nc(Nc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206672	76388	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	473	8	3	7	5.0	CCc1nc(N)nc(Nc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145962494	161525	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160705	161525	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44389215	62749	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178838	62749	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	11211892	79806	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	405	8	3	6	4.0	CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL213703	79806	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	405	8	3	6	4.0	CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	122180015	121062	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	523	9	2	8	5.3	CCCn1cc(-c2cnc(NCc3ccc4occc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586021	121062	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	523	9	2	8	5.3	CCCn1cc(-c2cnc(NCc3ccc4occc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	59446138	81209	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1cccc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163482	81209	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1cccc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	59446138	81209	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1cccc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163482	81209	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1cccc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	59446127	172467	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)N(CCc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL4518972	172467	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)N(CCc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	60195286	81201	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)N(CCc1ccccc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163474	81201	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)N(CCc1ccccc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	10207327	66736	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	CHEMBL18725	66736	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	16112911	84305	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	619	13	4	7	5.6	COc1ccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	CHEMBL222835	84305	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	619	13	4	7	5.6	COc1ccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	5311280	81197	1	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	1035	25	11	10	2.4	Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@@H]1Cc2cccc3c2N1C(=O)[C@@H](N)CC3)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163470	81197	1	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	1035	25	11	10	2.4	Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@@H]1Cc2cccc3c2N1C(=O)[C@@H](N)CC3)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44389243	64252	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	557	7	1	6	6.2	O=C(Nc1ccccc1C(=O)N1CCCCC1)c1c(-c2c(Cl)cccc2Cl)noc1CCC1OCCCO1	10.1016/j.bmcl.2004.11.075
	CHEMBL181619	64252	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	557	7	1	6	6.2	O=C(Nc1ccccc1C(=O)N1CCCCC1)c1c(-c2c(Cl)cccc2Cl)noc1CCC1OCCCO1	10.1016/j.bmcl.2004.11.075
	23648232	90812	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	506	11	3	5	4.5	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
	CHEMBL240179	90812	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	506	11	3	5	4.5	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
	44445616	161321	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	595	11	3	6	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL414930	161321	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	595	11	3	6	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	118709471	112961	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	361	3	2	5	3.9	COc1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319275	112961	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	361	3	2	5	3.9	COc1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	44390889	64092	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(OC)c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL181313	64092	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(OC)c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	46882270	5740	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078960	5740	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	156016696	177056	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641201	177056	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL3578016	210020	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	CHEMBL2163348	207579	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163348	207579	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	16113800	137287	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL375972	137287	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL3578016	210020	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	156013130	176928	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639514	176928	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156016696	177056	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641201	177056	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145950877	162445	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175360	162445	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44358041	160784	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	1724	59	24	24	-8.1	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm0001727
	91931457	160784	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	1724	59	24	24	-8.1	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm0001727
	CHEMBL412565	160784	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	1724	59	24	24	-8.1	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm0001727
	57422810	177087	2	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	602	7	2	10	4.4	CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1016/j.bmcl.2020.126953
	CHEMBL4641579	177087	2	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	602	7	2	10	4.4	CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1016/j.bmcl.2020.126953
	16113246	94239	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252643	94239	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	11846624	77563	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	490	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL209443	77563	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	490	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	46882272	5733	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	480	8	4	4	5.5	CC(C)c1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078900	5733	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	480	8	4	4	5.5	CC(C)c1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	9987037	11927	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1183385	11927	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL294324	11927	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	56942537	124680	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	551	12	2	6	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OCC(C)C)cc1	nan
	CHEMBL3645262	124680	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	551	12	2	6	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OCC(C)C)cc1	nan
	57422761	112941	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	510	10	3	8	3.3	COCCNCCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319214	112941	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	510	10	3	8	3.3	COCCNCCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	57422760	112938	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	480	7	2	7	3.6	CN(C)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319211	112938	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	480	7	2	7	3.6	CN(C)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	57422791	112953	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	601	8	2	10	3.5	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cccc(-n5cccn5)c4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319226	112953	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	601	8	2	10	3.5	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cccc(-n5cccn5)c4Cl)sc3c2)CC1	10.1021/jm500610n
	44445619	154139	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	541	10	2	5	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL399650	154139	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	541	10	2	5	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	16113469	136977	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	11	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	CHEMBL375408	136977	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	11	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	CHEMBL501253	212362	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CCCCCCCBr)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm8014519
	122182045	121486	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	554	9	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCO5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL3593634	121486	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	554	9	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCO5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	44446175	94546	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	13	3	7	4.7	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL254741	94546	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	13	3	7	4.7	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	10994861	66935	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	514	9	6	4	2.5	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
	CHEMBL18815	66935	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	514	9	6	4	2.5	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
	10984260	167790	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	529	9	7	5	1.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1(N)CCNCC1	10.1021/jm020985q
	CHEMBL434391	167790	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	529	9	7	5	1.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1(N)CCNCC1	10.1021/jm020985q
	59446135	81203	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	859	21	12	9	0.7	NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	nan
	CHEMBL2163476	81203	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	859	21	12	9	0.7	NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	nan
	59446135	81203	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	859	21	12	9	0.7	NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
	CHEMBL2163476	81203	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	859	21	12	9	0.7	NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
	59446154	81190	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	858	19	10	8	2.0	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(N)=O	nan
	CHEMBL2163453	81190	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	858	19	10	8	2.0	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(N)=O	nan
	59446154	81190	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	858	19	10	8	2.0	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(N)=O	10.1021/jm300557t
	CHEMBL2163453	81190	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	858	19	10	8	2.0	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(N)=O	10.1021/jm300557t
	44446178	154584	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL402023	154584	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	753168	122723	33	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	349	6	1	4	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL361366	122723	33	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	349	6	1	4	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44338253	9197	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	539	11	1	6	4.4	CN(C)CCCN1C(=O)[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
	CHEMBL110900	9197	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	539	11	1	6	4.4	CN(C)CCCN1C(=O)[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
	44301512	11917	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1183340	11917	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL291333	11917	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	16113799	168148	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL436849	168148	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	11166495	75199	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	437	8	2	7	4.5	N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL204474	75199	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	437	8	2	7	4.5	N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	25262772	112966	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	521	6	2	8	2.9	CN1CCN(CCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319281	112966	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	521	6	2	8	2.9	CN1CCN(CCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	44390869	121828	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(Cl)cc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL359922	121828	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(Cl)cc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	156013130	176928	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639514	176928	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	122180014	121061	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	539	9	2	8	5.8	CCCn1cc(-c2cnc(NCc3ccc4sccc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586020	121061	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	539	9	2	8	5.8	CCCn1cc(-c2cnc(NCc3ccc4sccc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	122178601	120823	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581034	120823	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	16202767	84572	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	506	9	3	5	4.8	Cc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL223810	84572	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	506	9	3	5	4.8	Cc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	46882156	5633	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	7	4	4	3.3	CC(C)NC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078115	5633	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	7	4	4	3.3	CC(C)NC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	16113474	136110	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	455	8	4	5	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nncn1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	CHEMBL373993	136110	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	455	8	4	5	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nncn1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	59446105	172252	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)N(Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL4514053	172252	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)N(Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	11556936	81199	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)N(Cc1ccc(O)cc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163472	81199	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)N(Cc1ccc(O)cc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	60195114	81196	0	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	640	13	8	6	1.8	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm300557t
	CHEMBL2163468	81196	0	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	640	13	8	6	1.8	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm300557t
	70690449	75518	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	486	9	0	5	4.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048810	75518	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	486	9	0	5	4.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	70692603	75524	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	463	7	0	5	5.0	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4nc5ccccc5s4)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048816	75524	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	463	7	0	5	5.0	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4nc5ccccc5s4)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	44389192	168081	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	471	4	1	4	6.2	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1	10.1016/j.bmcl.2004.11.075
	CHEMBL436275	168081	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	471	4	1	4	6.2	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1	10.1016/j.bmcl.2004.11.075
	44394982	65807	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	523	9	1	6	5.7	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL184093	65807	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	523	9	1	6	5.7	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL526723	213921	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL		None	None	None		CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm8014519
	CHEMBL335799	209818	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/jm0001727
	CHEMBL61663	214062	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/s0960-894x(01)00324-9
	44445628	161350	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	541	10	2	6	5.5	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL415135	161350	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	541	10	2	6	5.5	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	145950877	162445	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175360	162445	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	11663710	123948	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363995	123948	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	16113371	78743	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL2113318	78743	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	16113371	78743	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1021/jm0704550
	CHEMBL2113318	78743	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1021/jm0704550
	11713497	122721	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	531	9	1	6	6.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL361349	122721	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	531	9	1	6	6.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1	10.1016/j.bmcl.2004.11.075
	122182045	121486	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	554	9	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCO5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL3593634	121486	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	554	9	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCO5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	11646276	75581	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	CHEMBL205136	75581	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	122182046	121487	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593635	121487	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
	44436828	91568	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	11	4	6	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL241664	91568	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	11	4	6	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL410108	211052	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm0001727
	11538533	74651	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203280	74651	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL500468	212344	0	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm020985q
	11538534	74664	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL203373	74664	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	122182047	121488	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593636	121488	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	70686293	75530	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	472	5	0	7	3.8	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-c5ncccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048822	75530	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	472	5	0	7	3.8	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-c5ncccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	122180016	121063	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	540	9	2	9	5.1	CCCn1cc(-c2cnc(NCc3ccc4ncsc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586022	121063	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	540	9	2	9	5.1	CCCn1cc(-c2cnc(NCc3ccc4ncsc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	44389216	123336	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	442	6	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL362595	123336	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	442	6	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1	10.1016/j.bmcl.2004.11.075
	44389248	121654	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	433	7	2	5	5.0	CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359714	121654	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	433	7	2	5	5.0	CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	145958774	161716	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163811	161716	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	44445609	96592	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	579	10	3	5	6.4	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL266961	96592	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	579	10	3	5	6.4	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	16114532	84272	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccccc1Cn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL222610	84272	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccccc1Cn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	23648250	78753	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	585	10	4	5	6.0	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL2113327	78753	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	585	10	4	5	6.0	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	44409764	76796	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	488	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207792	76796	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	488	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44378979	12735	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	5	4.6	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1188586	12735	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	5	4.6	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL536779	12735	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	5	4.6	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	11197	1049	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	572	7	2	9	3.9	CCOc1cc(Cl)c(cc1N1CCOCC1)C(=O)NC(=O)Nc1nc2c(s1)cc(cc2)CN1CCN(CC1)C	10.1016/j.bmcl.2020.126953
	154699458	1049	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	572	7	2	9	3.9	CCOc1cc(Cl)c(cc1N1CCOCC1)C(=O)NC(=O)Nc1nc2c(s1)cc(cc2)CN1CCN(CC1)C	10.1016/j.bmcl.2020.126953
	CHEMBL4632411	1049	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	572	7	2	9	3.9	CCOc1cc(Cl)c(cc1N1CCOCC1)C(=O)NC(=O)Nc1nc2c(s1)cc(cc2)CN1CCN(CC1)C	10.1016/j.bmcl.2020.126953
	CHEMBL498956	212317	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL		None	None	None		CCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm8014519
	46882198	5683	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.9	CCCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078497	5683	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.9	CCCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL3578017	210021	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	CHEMBL3578017	210021	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	145953855	161965	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167669	161965	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	90666035	108830	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	437	6	0	8	2.8	COc1cccc(-n2cc3nc(C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218908	108830	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	437	6	0	8	2.8	COc1cccc(-n2cc3nc(C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	328912	62247	1	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	505	5	1	4	7.0	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C	10.1016/j.bmcl.2004.11.075
	CHEMBL178266	62247	1	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	505	5	1	4	7.0	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C	10.1016/j.bmcl.2004.11.075
	178024	1940	30	None	-	1	Human	9.9	pKd	=	9.9	Binding	Compound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activityCompound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activity	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm970342o
	5867	1940	30	None	-	1	Human	9.9	pKd	=	9.9	Binding	Compound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activityCompound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activity	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm970342o
	CHEMBL13817	1940	30	None	-	1	Human	9.9	pKd	=	9.9	Binding	Compound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activityCompound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activity	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm970342o
	57398340	70932	0	None	-	1	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	449	5	0	8	4.6	Cc1nc2ccc(Oc3ccc4ncsc4c3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956993	70932	0	None	-	1	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	449	5	0	8	4.6	Cc1nc2ccc(Oc3ccc4ncsc4c3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57400002	70933	0	None	-	1	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	488	5	0	6	4.9	Cc1nc2ccc(Oc3ccc(Br)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956994	70933	0	None	-	1	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	488	5	0	6	4.9	Cc1nc2ccc(Oc3ccc(Br)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57394881	70949	0	None	-	1	Human	10.3	pKi	=	10.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	489	5	0	7	4.3	Cc1nc2ncc(Oc3ccc(Br)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957010	70949	0	None	-	1	Human	10.3	pKi	=	10.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	489	5	0	7	4.3	Cc1nc2ncc(Oc3ccc(Br)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57393073	70940	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	449	5	0	8	4.6	Cc1nc2cnc(Oc3ccc4ncsc4c3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957001	70940	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	449	5	0	8	4.6	Cc1nc2cnc(Oc3ccc4ncsc4c3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	56926461	68694	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923609	68694	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926462	68695	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923610	68695	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	56926680	68708	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923623	68708	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	56926682	68710	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923625	68710	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	11664206	68711	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923626	68711	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	56926893	68721	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	nan
	CHEMBL1923637	68721	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	nan
	11526745	68726	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923642	68726	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134137202	142294	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	5	3	6	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3893048	142294	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	5	3	6	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134137257	142605	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	540	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3895776	142605	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	540	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134133352	142973	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3898794	142973	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O	nan
	11527086	143518	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3903118	143518	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	11512561	143836	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3905791	143836	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134133037	144034	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3907497	144034	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134132670	144081	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3907891	144081	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134132152	144399	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3910300	144399	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O	nan
	134142839	144853	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3913855	144853	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134142553	144914	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3914259	144914	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134143635	145041	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3915269	145041	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O	nan
	134143096	145400	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	584	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(Br)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3918009	145400	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	584	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(Br)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134142204	145404	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3918046	145404	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	11584702	145658	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	540	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3920049	145658	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	540	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134139279	145914	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	4	4	5	4.1	CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3922056	145914	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	4	4	5	4.1	CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134138445	146844	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NC/C=C/c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3929593	146844	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NC/C=C/c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134138218	147477	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3934367	147477	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134148686	147639	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3935670	147639	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134149719	148155	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	2	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C(C)(C)C)C(=O)N1C	nan
	CHEMBL3939872	148155	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	2	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C(C)(C)C)C(=O)N1C	nan
	134145791	148254	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3940705	148254	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134143746	150067	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	2	4	5	3.9	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1cccc(Cl)c1	nan
	CHEMBL3955179	150067	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	2	4	5	3.9	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1cccc(Cl)c1	nan
	134145221	150099	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CCC(C)C1NC[C@H](C)Oc2ccccc2CCCNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3955437	150099	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CCC(C)C1NC[C@H](C)Oc2ccccc2CCCNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134155656	150662	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3959816	150662	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134155282	150810	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3961108	150810	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134153496	151753	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.4	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3969367	151753	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.4	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134153654	152234	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	632	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(I)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3973513	152234	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	632	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(I)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134157569	153502	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	560	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2cc(F)c(F)c(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3984338	153502	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	560	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2cc(F)c(F)c(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	57345600	70929	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	488	5	0	6	4.9	Cc1nc2ncc(Oc3ccc(Br)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956990	70929	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	488	5	0	6	4.9	Cc1nc2ncc(Oc3ccc(Br)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57345599	70930	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	444	5	0	6	4.8	Cc1nc2ccc(Oc3ccc(Cl)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956991	70930	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	444	5	0	6	4.8	Cc1nc2ccc(Oc3ccc(Cl)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57398341	70938	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	444	5	0	6	4.8	Cc1nc2cnc(Oc3ccc(Cl)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956999	70938	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	444	5	0	6	4.8	Cc1nc2cnc(Oc3ccc(Cl)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	178024	1940	30	None	-	1	Human	9.6	pKi	=	9.6	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm960054c
	5867	1940	30	None	-	1	Human	9.6	pKi	=	9.6	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm960054c
	CHEMBL13817	1940	30	None	-	1	Human	9.6	pKi	=	9.6	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm960054c
	57398342	70946	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	450	5	0	9	4.0	Cc1nc2ncc(Oc3ccc4ncsc4c3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957007	70946	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	450	5	0	9	4.0	Cc1nc2ncc(Oc3ccc4ncsc4c3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57401803	70948	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	469	6	0	7	5.1	Cc1nc2ncc(Oc3ccc(-c4ccccc4)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957009	70948	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	469	6	0	7	5.1	Cc1nc2ncc(Oc3ccc(-c4ccccc4)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57401799	70939	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	436	5	0	8	3.7	Cc1nc2cnc(Oc3ccc4c(c3)OCO4)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957000	70939	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	436	5	0	8	3.7	Cc1nc2cnc(Oc3ccc4c(c3)OCO4)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57399248	68702	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923617	68702	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	44340008	112889	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	583	9	2	6	3.2	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)c(F)c1)C(=O)N1CCC2=NN(C(C)(C)C)C(=O)C2(Cc2ccccc2)C1	10.1016/s0960-894x(02)00734-5
	CHEMBL331801	112889	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	583	9	2	6	3.2	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)c(F)c1)C(=O)N1CCC2=NN(C(C)(C)C)C(=O)C2(Cc2ccccc2)C1	10.1016/s0960-894x(02)00734-5
	57399248	68702	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923617	68702	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	24970113	68714	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	580	3	3	5	3.8	C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923629	68714	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	580	3	3	5	3.8	C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	57391293	70936	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	468	6	0	6	5.7	Cc1nc2ccc(Oc3ccc(-c4ccccc4)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956997	70936	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	468	6	0	6	5.7	Cc1nc2ccc(Oc3ccc(-c4ccccc4)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	162659411	180643	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	575	13	3	7	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CC#N)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4761419	180643	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	575	13	3	7	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CC#N)cc1	10.1021/acs.jmedchem.9b02122
	44340268	110032	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	609	10	2	6	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)c(F)c1)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)C2(Cc2ccccc2)C1	10.1016/s0960-894x(02)00734-5
	CHEMBL325062	110032	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	609	10	2	6	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)c(F)c1)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)C2(Cc2ccccc2)C1	10.1016/s0960-894x(02)00734-5
	57401800	70942	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	446	5	0	8	3.9	Cc1nc2cnc(Oc3ccc4c(c3)ncn4C)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957003	70942	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	446	5	0	8	3.9	Cc1nc2cnc(Oc3ccc4c(c3)ncn4C)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	162657606	180535	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	693	15	3	8	5.7	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4760409	180535	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	693	15	3	8	5.7	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	57401801	70944	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	445	5	0	7	4.2	Cc1nc2ncc(Oc3ccc(Cl)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957005	70944	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	445	5	0	7	4.2	Cc1nc2ncc(Oc3ccc(Cl)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	162672839	182440	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	681	14	3	7	5.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4793824	182440	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	681	14	3	7	5.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL500468	212344	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm300414b
	56942242	124675	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645257	124675	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	56925343	68724	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923640	68724	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	57398339	70931	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	436	5	0	8	3.7	Cc1nc2ccc(Oc3ccc4c(c3)OCO4)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956992	70931	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	436	5	0	8	3.7	Cc1nc2ccc(Oc3ccc4c(c3)OCO4)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	162645413	179146	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	677	14	3	7	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4744051	179146	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	677	14	3	7	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	155540883	172388	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172388	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	16133832	211583	15	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/acs.jmedchem.8b01644
	CHEMBL425281	211583	15	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/acs.jmedchem.8b01644
	162653781	179900	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	732	15	4	8	6.2	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753046	179900	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	732	15	4	8	6.2	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	57401802	70945	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	437	5	0	9	3.1	Cc1nc2ncc(Oc3ccc4c(c3)OCO4)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957006	70945	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	437	5	0	9	3.1	Cc1nc2ncc(Oc3ccc4c(c3)OCO4)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57401797	70925	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	468	6	0	6	5.7	Cc1nc2ncc(Oc3ccc(-c4ccccc4)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956987	70925	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	468	6	0	6	5.7	Cc1nc2ncc(Oc3ccc(-c4ccccc4)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57398343	70947	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	462	5	0	8	4.1	Cc1nc2ncc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957008	70947	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	462	5	0	8	4.1	Cc1nc2ncc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	56926175	68671	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923504	68671	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	56926360	68693	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	3	5	2.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923608	68693	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	3	5	2.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926582	68701	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923616	68701	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926681	68709	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2cccc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923624	68709	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2cccc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	56926891	68719	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923635	68719	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926892	68720	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923636	68720	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926894	68722	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1923638	68722	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	56925345	68727	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923643	68727	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134130631	141841	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	5	4	6	3.4	COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1	nan
	CHEMBL3889512	141841	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	5	4	6	3.4	COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1	nan
	134131442	141864	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3889678	141864	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134131183	141936	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3890296	141936	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134136433	141975	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	5	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(OC)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3890602	141975	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	5	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(OC)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134137008	142011	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	4	5	3.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3890889	142011	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	4	5	3.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134137012	142070	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	3	3	6	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccsc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3891381	142070	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	3	3	6	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccsc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134137398	142344	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	4	4	4	4.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3893476	142344	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	4	4	4	4.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134136665	142367	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	5	6	3.9	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc(O)cc1	nan
	CHEMBL3893697	142367	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	5	6	3.9	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc(O)cc1	nan
	134133488	142704	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	600	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3896536	142704	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	600	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134134248	142819	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	5	3	5	4.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](C(c2ccccc2)c2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3897510	142819	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	5	3	5	4.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](C(c2ccccc2)c2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134134556	142820	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	3	4	5	2.7	CC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3897527	142820	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	3	4	5	2.7	CC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134133518	142921	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	4	5	3.4	CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	CHEMBL3898348	142921	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	4	5	3.4	CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	134134286	143162	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	5	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3900284	143162	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	5	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134135296	143479	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	3	4	5	3.0	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3902856	143479	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	3	4	5	3.0	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134132958	144128	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	3	3	5	2.4	C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C	nan
	CHEMBL3908264	144128	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	3	3	5	2.4	C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C	nan
	134132137	144280	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	4	3.5	CCC(C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccc(F)cc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3909431	144280	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	4	3.5	CCC(C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccc(F)cc2)NC(=O)C(C)N(C)C1=O	nan
	134132893	144330	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	4	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3909834	144330	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	4	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	24969783	144331	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccc(F)cc2O1	nan
	CHEMBL3909838	144331	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccc(F)cc2O1	nan
	130334810	144627	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@@H](C2=O)N(C)C1=O	nan
	CHEMBL3912211	144627	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@@H](C2=O)N(C)C1=O	nan
	134132394	144651	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccn2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3912375	144651	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccn2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134142218	144754	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	4	5	3.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3913052	144754	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	4	5	3.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134142433	144793	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	3	4	6	1.8	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3913335	144793	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	3	4	6	1.8	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O	nan
	59778970	144842	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	4	3	6	1.8	COC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3913763	144842	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	4	3	6	1.8	COC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134143366	145227	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	4	4.6	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3916659	145227	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	4	4.6	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	117812386	145325	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3917385	145325	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134139489	145529	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2cc(F)cc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3919021	145529	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2cc(F)cc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134140270	145840	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	5	3.1	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3921499	145840	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	5	3.1	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134140007	145871	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)c(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3921750	145871	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)c(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134139286	146021	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3922810	146021	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134139113	146120	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC)N(C)C1=O	nan
	CHEMBL3923633	146120	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC)N(C)C1=O	nan
	134141159	146196	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3924192	146196	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134140968	146257	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	3	3	5	2.4	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCNC(C2CC2)C(=O)N1C	nan
	CHEMBL3924635	146257	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	3	3	5	2.4	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCNC(C2CC2)C(=O)N1C	nan
	134141782	146461	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	4	4.6	CCC(C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3926434	146461	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	4	4.6	CCC(C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134141886	146585	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3927481	146585	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134138234	146880	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	3	3	5	2.4	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccc3c(c2)OC(CC3)CN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3929852	146880	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	3	3	5	2.4	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccc3c(c2)OC(CC3)CN[C@@H](C2CC2)C(=O)N1C	nan
	117812380	147219	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3932408	147219	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134138595	147222	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	544	2	4	5	3.3	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1	nan
	CHEMBL3932434	147222	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	544	2	4	5	3.3	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1	nan
	134138824	147482	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	525	3	3	6	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3934402	147482	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	525	3	3	6	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134148504	147822	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.4	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3937200	147822	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.4	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134149092	147921	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	4	5	2.5	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	CHEMBL3937924	147921	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	4	5	2.5	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	134149306	147942	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	3	3	5	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3938104	147942	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	3	3	5	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134149407	147988	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	571	4	4	6	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(C#N)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3938452	147988	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	571	4	4	6	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(C#N)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134148639	148011	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	5	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCNC2)NC1=O	nan
	CHEMBL3938683	148011	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	5	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCNC2)NC1=O	nan
	134146570	148248	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3940653	148248	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134145552	148487	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(CC)C1=O	nan
	CHEMBL3942528	148487	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(CC)C1=O	nan
	134145564	148558	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3943086	148558	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	72574018	148572	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CCC(C)C1NCC(C)Oc2ccccc2CCCNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3943159	148572	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CCC(C)C1NCC(C)Oc2ccccc2CCCNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134146319	148594	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CC(C)CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3943294	148594	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CC(C)CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134147809	148917	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3946007	148917	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134147441	148957	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	2	4	5	3.0	C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	CHEMBL3946348	148957	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	2	4	5	3.0	C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	134146888	149231	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	624	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Br)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3948268	149231	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	624	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Br)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134147381	149253	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3948472	149253	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134147802	149559	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3950904	149559	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134145064	149617	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	4	5	3.4	CC1(C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3951476	149617	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	4	5	3.4	CC1(C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134144205	149741	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(C(F)(F)F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3952596	149741	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(C(F)(F)F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134144429	149753	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3952699	149753	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134144211	149798	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2C#CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3953033	149798	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2C#CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134144606	149802	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3953053	149802	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)C2(CCCC2)NC1=O	nan
	134155024	150480	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.6	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3958451	150480	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.6	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134155239	150482	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	3	4	5	3.4	O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1	nan
	CHEMBL3958460	150482	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	3	4	5	3.4	O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1	nan
	134155132	150560	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	502	4	3	5	2.9	CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3959108	150560	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	502	4	3	5	2.9	CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	134155178	150847	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	525	3	3	6	1.6	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCNC(C2CC2)C(=O)N1C	nan
	CHEMBL3961456	150847	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	525	3	3	6	1.6	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCNC(C2CC2)C(=O)N1C	nan
	134150646	151114	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	558	5	3	6	2.6	CSCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3963865	151114	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	558	5	3	6	2.6	CSCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134150029	151583	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.3	CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3967783	151583	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.3	CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134150729	151624	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	3	3	5	2.1	CC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3968175	151624	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	3	3	5	2.1	CC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154254	151767	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	4	3.5	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3969506	151767	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	4	3.5	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154486	151910	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	3	5	3.3	C[C@@H]1C(=O)N[C@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)N1C	nan
	CHEMBL3970827	151910	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	3	5	3.3	C[C@@H]1C(=O)N[C@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)N1C	nan
	134154392	152000	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	5	3.1	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3971540	152000	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	5	3.1	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134153247	152188	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	6	2.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3973085	152188	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	6	2.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	134153772	152366	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	528	4	3	6	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccs2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3974701	152366	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	528	4	3	6	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccs2)NC(=O)[C@@H](C)N(C)C1=O	nan
	52911621	152527	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	531	3	3	6	1.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3975975	152527	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	531	3	3	6	1.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134151758	152570	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	558	3	3	5	2.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(Cl)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3976294	152570	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	558	3	3	5	2.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(Cl)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134152984	152634	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	6	2.9	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3976853	152634	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	6	2.9	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	134151899	152785	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3978207	152785	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	134152339	152925	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	545	3	4	5	2.6	C[C@@H]1C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3979468	152925	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	545	3	4	5	2.6	C[C@@H]1C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134152133	152989	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	3	4	6	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(O)c(C(C)(C)C)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3979911	152989	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	3	4	6	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(O)c(C(C)(C)C)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134157813	153138	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	4	3	6	1.7	COC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3981238	153138	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	4	3	6	1.7	COC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134156963	153324	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3982825	153324	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CCCC2)NC1=O	nan
	57528321	153423	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	2	2	5	2.6	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN2CCCC[C@H]2C(=O)N1C	nan
	CHEMBL3983626	153423	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	2	2	5	2.6	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN2CCCC[C@H]2C(=O)N1C	nan
	134156579	153520	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)c(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3984464	153520	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)c(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134156405	153728	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	620	4	4	6	4.3	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccsc1	nan
	CHEMBL3986375	153728	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	620	4	4	6	4.3	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccsc1	nan
	134156453	153766	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccncc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3986628	153766	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccncc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56942098	124673	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645255	124673	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	162646324	179156	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	688	17	3	9	4.8	CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4744139	179156	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	688	17	3	9	4.8	CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	162665018	181553	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	550	12	3	6	4.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(C)=O)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4782214	181553	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	550	12	3	6	4.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(C)=O)cc1	10.1021/acs.jmedchem.9b02122
	58438451	91853	0	None	2089	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	442	4	0	6	3.1	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426689	91853	0	None	2089	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	442	4	0	6	3.1	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	90644553	111243	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	540	5	1	7	4.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ccc(C(N)=O)nc6)ccc53)C4)nc2s1	10.1021/ml400473x
	CHEMBL3287214	111243	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	540	5	1	7	4.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ccc(C(N)=O)nc6)ccc53)C4)nc2s1	10.1021/ml400473x
	56926177	68673	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923506	68673	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	56926268	68675	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	4	3	5	2.5	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](Cc2ccccc2)C1=O	nan
	CHEMBL1923510	68675	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	4	3	5	2.5	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](Cc2ccccc2)C1=O	nan
	56926269	68676	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	460	5	3	5	2.0	CCCC[C@H]1NC(=O)CN(C)C(=O)[C@H](CCC)NCCOc2ccccc2CCCNC1=O	nan
	CHEMBL1923511	68676	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	460	5	3	5	2.0	CCCC[C@H]1NC(=O)CN(C)C(=O)[C@H](CCC)NCCOc2ccccc2CCCNC1=O	nan
	56926356	68677	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923512	68677	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	nan
	56926465	68698	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	CHEMBL1923613	68698	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	56926782	68715	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923631	68715	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926784	68717	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923633	68717	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926785	68718	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923634	68718	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	71452183	83116	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	nan
	CHEMBL2203623	83116	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	nan
	134131439	141863	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	527	4	4	6	1.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCN)C(=O)N1C	nan
	CHEMBL3889672	141863	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	527	4	4	6	1.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCN)C(=O)N1C	nan
	134137460	142103	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	CHEMBL3891657	142103	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	134136637	142188	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	541	5	4	6	1.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCN)C(=O)N1C	nan
	CHEMBL3892319	142188	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	541	5	4	6	1.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCN)C(=O)N1C	nan
	134136946	142222	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	566	5	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccc(C(=O)O)cc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3892517	142222	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	566	5	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccc(C(=O)O)cc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134136405	142387	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	616	4	4	5	4.6	CC[C@H](C)[C@@H]1NCCOc2ccc(Cl)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3893850	142387	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	616	4	4	5	4.6	CC[C@H](C)[C@@H]1NCCOc2ccc(Cl)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134133771	142809	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	4	3	5	2.3	CCC[C@H]1NC(=O)[C@@H](C)N(C)C(=O)[C@H]([C@@H](C)CC)NCCOc2ccccc2CCCNC1=O	nan
	CHEMBL3897387	142809	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	4	3	5	2.3	CCC[C@H]1NC(=O)[C@@H](C)N(C)C(=O)[C@H]([C@@H](C)CC)NCCOc2ccccc2CCCNC1=O	nan
	134133353	142987	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	5	3	5	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)N(C)C1=O	nan
	CHEMBL3898864	142987	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	5	3	5	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)N(C)C1=O	nan
	134134505	143136	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	4	4.3	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3900035	143136	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	4	4.3	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134134605	143145	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	3	3	5	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3900122	143145	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	3	3	5	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	134134099	143199	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	639	4	4	6	4.1	N#Cc1ccccc1C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3900636	143199	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	639	4	4	6	4.1	N#Cc1ccccc1C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134135897	143462	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	530	4	4	4	4.0	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3902804	143462	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	530	4	4	4	4.0	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134134825	143547	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	476	3	3	5	1.4	C[C@@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NCCCCCOCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3903351	143547	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	476	3	3	5	1.4	C[C@@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NCCCCCOCCN[C@@H](C2CC2)C(=O)N1C	nan
	72989837	143583	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	5	4	6	1.7	CCC(C)C1NCCOc2ccccc2CCCNC(=O)C(Cc2ccccc2)NC(=O)C(CO)N(C)C1=O	nan
	CHEMBL3903647	143583	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	5	4	6	1.7	CCC(C)C1NCCOc2ccccc2CCCNC(=O)C(Cc2ccccc2)NC(=O)C(CO)N(C)C1=O	nan
	134135712	143606	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	533	4	4	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O	nan
	CHEMBL3903845	143606	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	533	4	4	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O	nan
	134136025	143800	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	6	4	6	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](COCc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	CHEMBL3905495	143800	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	6	4	6	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](COCc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	134134870	143859	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	3	4	5	2.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3905987	143859	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	3	4	5	2.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134135261	143952	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC)N(C)C1=O	nan
	CHEMBL3906788	143952	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC)N(C)C1=O	nan
	134134893	143978	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	3	5	3.3	C[C@H]1C(=O)N[C@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)N1C	nan
	CHEMBL3907031	143978	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	3	5	3.3	C[C@H]1C(=O)N[C@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)N1C	nan
	134132666	144032	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2cccnc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3907480	144032	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2cccnc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134132519	144116	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	4	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccsc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3908156	144116	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	4	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccsc2)NC(=O)C2(CCCC2)NC1=O	nan
	134132427	144168	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	622	5	4	5	5.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3908583	144168	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	622	5	4	5	5.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134131971	144395	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2C(C)CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3910288	144395	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2C(C)CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134132265	144438	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	3	4	6	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O	nan
	CHEMBL3910661	144438	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	3	4	6	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O	nan
	134131903	144605	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	529	4	3	7	2.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cscn2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3912034	144605	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	529	4	3	7	2.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cscn2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134132099	144677	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	4	4	6	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccs2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3912534	144677	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	4	4	6	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccs2)NC(=O)C2(CCCC2)NC1=O	nan
	134142223	144810	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	480	4	4	5	1.7	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CNC1=O	nan
	CHEMBL3913486	144810	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	480	4	4	5	1.7	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CNC1=O	nan
	134142139	144869	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	610	5	4	6	3.6	COc1ccc(C[C@@H]2NCCOc3ccccc3/C=C\CNC(=O)[C@H](Cc3ccccc3)NC(=O)C3(CCCC3)NC2=O)cc1	nan
	CHEMBL3913981	144869	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	610	5	4	6	3.6	COc1ccc(C[C@@H]2NCCOc3ccccc3/C=C\CNC(=O)[C@H](Cc3ccccc3)NC(=O)C3(CCCC3)NC2=O)cc1	nan
	76460236	144927	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	4	3.0	CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3914338	144927	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	4	3.0	CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134143044	144940	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	488	4	3	5	2.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3914467	144940	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	488	4	3	5	2.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@@H](C)N(C)C1=O	nan
	134143657	145203	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	528	4	3	6	1.4	COC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3916501	145203	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	528	4	3	6	1.4	COC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134143398	145401	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	3	3	5	2.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCC(C)(C)c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3918022	145401	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	3	3	5	2.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCC(C)(C)c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134139992	145806	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccccc1Cl	nan
	CHEMBL3921227	145806	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccccc1Cl	nan
	134140213	146087	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	513	3	4	6	0.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CN)C(=O)N1C	nan
	CHEMBL3923324	146087	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	513	3	4	6	0.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CN)C(=O)N1C	nan
	134140762	146132	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	505	4	2	5	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@@H](C1=O)C2=O	nan
	CHEMBL3923718	146132	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	505	4	2	5	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@@H](C1=O)C2=O	nan
	134141057	146162	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	3	4	5	2.7	CCC1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3923918	146162	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	3	4	5	2.7	CCC1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134140844	146692	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccc(Cl)c1	nan
	CHEMBL3928367	146692	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccc(Cl)c1	nan
	68186750	146854	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.8	CC1CCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)NCCOc2ccccc21	nan
	CHEMBL3929656	146854	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.8	CC1CCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)NCCOc2ccccc21	nan
	134138656	147021	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3930811	147021	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134138764	147103	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	566	5	3	7	2.1	COc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1OC	nan
	CHEMBL3931402	147103	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	566	5	3	7	2.1	COc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1OC	nan
	134138160	147132	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	4	4	6	1.4	CCC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3931716	147132	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	4	4	6	1.4	CCC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134137758	147441	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	500	7	4	5	3.2	CCCC[C@@H]1NC(=O)[C@H](CCCC)NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C\CNC1=O	nan
	CHEMBL3934093	147441	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	500	7	4	5	3.2	CCCC[C@@H]1NC(=O)[C@H](CCCC)NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C\CNC1=O	nan
	134137945	147453	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	3	4	5	3.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(Cc3ccccc3C2)NC1=O	nan
	CHEMBL3934184	147453	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	3	4	5	3.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(Cc3ccccc3C2)NC1=O	nan
	134149048	147544	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	5	6	1.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@H]1CO	nan
	CHEMBL3934901	147544	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	5	6	1.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@H]1CO	nan
	134149058	147602	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	586	4	4	6	3.6	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccs1	nan
	CHEMBL3935422	147602	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	586	4	4	6	3.6	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccs1	nan
	134149451	147633	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3935626	147633	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134148804	147786	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	3	4	6	2.9	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCSCC2)NC1=O	nan
	CHEMBL3936957	147786	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	3	4	6	2.9	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCSCC2)NC1=O	nan
	58012657	147833	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	544	4	3	5	3.9	CCC[C@@H]1NCc2ccccc2Sc2ccccc2CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3937314	147833	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	544	4	3	5	3.9	CCC[C@@H]1NCc2ccccc2Sc2ccccc2CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	134149772	147947	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	592	4	4	4	5.0	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3938132	147947	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	592	4	4	4	5.0	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134149793	148073	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	5	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O	nan
	CHEMBL3939196	148073	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	5	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O	nan
	134148754	148167	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	646	8	3	6	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C(COCc2ccccc2)N(C)C1=O	nan
	CHEMBL3939993	148167	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	646	8	3	6	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C(COCc2ccccc2)N(C)C1=O	nan
	134145258	148270	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	4	4.8	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3940860	148270	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	4	4.8	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134145652	148491	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	6	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](COCc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3942543	148491	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	6	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](COCc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134145920	148494	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	2	4	5	2.3	C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3942554	148494	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	2	4	5	2.3	C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134146710	148498	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	587	4	4	7	3.0	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cscn1	nan
	CHEMBL3942610	148498	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	587	4	4	7	3.0	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cscn1	nan
	134145820	148502	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3942642	148502	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134146617	148583	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	4	5	3.0	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3943228	148583	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	4	5	3.0	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134145420	148781	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	6	3	5	3.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)CC)N(C)C1=O	nan
	CHEMBL3944936	148781	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	6	3	5	3.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)CC)N(C)C1=O	nan
	134147617	148903	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	CHEMBL3945918	148903	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	134147244	148914	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	4	6	2.0	CC[C@H](C)[C@@H]1NCCOCCOCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3945984	148914	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	4	6	2.0	CC[C@H](C)[C@@H]1NCCOCCOCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134148131	149166	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	568	4	4	6	2.6	COC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3947758	149166	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	568	4	4	6	2.6	COC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134147387	149285	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	4	4	3.9	CC[C@H](C)[C@@H]1NCCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3948746	149285	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	4	4	3.9	CC[C@H](C)[C@@H]1NCCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134147861	149325	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	526	2	4	5	2.9	CC1(C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C(C)(C)NC1=O	nan
	CHEMBL3949023	149325	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	526	2	4	5	2.9	CC1(C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C(C)(C)NC1=O	nan
	134147972	149406	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	488	4	3	5	2.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3949704	149406	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	488	4	3	5	2.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](C)N(C)C1=O	nan
	134147412	149434	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.4	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2cccc(C(F)(F)F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3949926	149434	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.4	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2cccc(C(F)(F)F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134148083	149579	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	3	4	5	3.4	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCCC2)NC1=O	nan
	CHEMBL3951110	149579	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	3	4	5	3.4	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCCC2)NC1=O	nan
	134144491	149608	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	4	4	3.5	CC[C@H](C)[C@@H]1NCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3951362	149608	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	4	4	3.5	CC[C@H](C)[C@@H]1NCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134143693	149624	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	4	5	3.1	CC[C@H](C)[C@@H]1NCCOCCCCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3951593	149624	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	4	5	3.1	CC[C@H](C)[C@@H]1NCCOCCCCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134145200	149919	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	6	4	6	2.8	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(COCc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	CHEMBL3954124	149919	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	6	4	6	2.8	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(COCc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	134144043	149956	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	570	4	5	6	2.3	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1c[nH]cn1	nan
	CHEMBL3954394	149956	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	570	4	5	6	2.3	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1c[nH]cn1	nan
	134144941	149994	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2cc(F)cc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3954620	149994	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2cc(F)cc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134144060	150124	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3955632	150124	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134155541	150505	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CCC(C)C1NCCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3958657	150505	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CCC(C)C1NCCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134155247	150518	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	4	5	4.7	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc2ccccc2c1	nan
	CHEMBL3958739	150518	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	4	5	4.7	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc2ccccc2c1	nan
	117812381	150819	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	592	3	3	5	3.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(C(F)(F)F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3961160	150819	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	592	3	3	5	3.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(C(F)(F)F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134155292	150870	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	458	4	3	5	1.3	CC[C@H](C)[C@@H]1NCCOC/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3961641	150870	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	458	4	3	5	1.3	CC[C@H](C)[C@@H]1NCCOC/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154704	150878	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	2	4	5	3.1	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)C2(CCCC2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3961696	150878	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	2	4	5	3.1	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)C2(CCCC2)NC(=O)C2(CCCC2)NC1=O	nan
	134152627	151016	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3963078	151016	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134150950	151073	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	5	4	5	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC1=O	nan
	CHEMBL3963523	151073	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	5	4	5	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC1=O	nan
	57528212	151291	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	2	2	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN2CCC[C@H]2C(=O)N1C	nan
	CHEMBL3965338	151291	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	2	2	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN2CCC[C@H]2C(=O)N1C	nan
	134150767	151294	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	2	4	5	3.0	C[C@@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	CHEMBL3965351	151294	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	2	4	5	3.0	C[C@@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	134150369	151324	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2cc(F)ccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)N(C)C1=O	nan
	CHEMBL3965516	151324	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2cc(F)ccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)N(C)C1=O	nan
	134150388	151393	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(NS(C)(=O)=O)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3966251	151393	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(NS(C)(=O)=O)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134150696	151547	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	3.2	CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3967506	151547	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	3.2	CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134153608	151838	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	3.2	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3970180	151838	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	3.2	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154369	151862	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3970414	151862	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134153972	151870	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	526	3	3	6	1.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCOc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3970491	151870	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	526	3	3	6	1.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCOc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134154079	151871	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	4	4	5	3.2	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3970499	151871	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	4	4	5	3.2	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O	nan
	134153529	151916	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	5	4	5	3.4	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3970856	151916	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	5	4	5	3.4	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134154612	151979	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@H](C2=O)N(C)C1=O	nan
	CHEMBL3971356	151979	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@H](C2=O)N(C)C1=O	nan
	134153232	152047	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.5	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@H]1Cc1ccccc1	nan
	CHEMBL3971845	152047	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.5	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@H]1Cc1ccccc1	nan
	134154534	152212	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	3	3	5	1.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC/C=C\COCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3973254	152212	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	3	3	5	1.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC/C=C\COCCN[C@@H](C2CC2)C(=O)N1C	nan
	134154022	152293	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3973940	152293	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134151581	152674	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	610	4	4	5	4.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2C(C)(C)CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3977241	152674	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	610	4	4	5	4.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2C(C)(C)CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	57528347	152678	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	nan
	CHEMBL3977265	152678	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	nan
	134152388	152684	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	5	4	5	4.0	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1CCc1ccccc1	nan
	CHEMBL3977294	152684	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	5	4	5	4.0	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1CCc1ccccc1	nan
	134151706	152820	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.4	CC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3978455	152820	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.4	CC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134151524	152846	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	644	5	4	6	4.2	COc1ccccc1C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3978661	152846	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	644	5	4	6	4.2	COc1ccccc1C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134152209	152868	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	3	4	6	1.0	CC(O)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3978864	152868	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	3	4	6	1.0	CC(O)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134152547	152949	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	5	2.9	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3979606	152949	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	5	2.9	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	11421086	153032	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	2	5	2.8	CCC[C@H]1C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN1C	nan
	CHEMBL3980276	153032	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	2	5	2.8	CCC[C@H]1C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN1C	nan
	134157913	153097	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	3	4	5	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	CHEMBL3980873	153097	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	3	4	5	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	134156625	153117	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	5	1.7	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3981072	153117	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	5	1.7	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134157438	153214	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	505	4	5	5	1.9	CC[C@H](C)[C@@H]1NCCCNCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3981843	153214	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	505	4	5	5	1.9	CC[C@H](C)[C@@H]1NCCCNCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134157625	153227	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccc(F)c(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3981960	153227	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccc(F)c(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	59834193	153618	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.5	CC1CNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)NCCOc2ccccc2C1	nan
	CHEMBL3985477	153618	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.5	CC1CNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)NCCOc2ccccc2C1	nan
	134156443	153812	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	5	3	5	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)N(C)C1=O	nan
	CHEMBL3986906	153812	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	5	3	5	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)N(C)C1=O	nan
	56926176	68672	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923505	68672	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	56926266	68674	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	6	4	6	1.4	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCCN)C1=O	nan
	CHEMBL1923508	68674	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	6	4	6	1.4	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCCN)C1=O	nan
	134133634	143102	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	549	4	4	6	2.7	CC(C)C[C@@H]1NCCOc2cccnc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3899825	143102	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	549	4	4	6	2.7	CC(C)C[C@@H]1NCCOc2cccnc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	57722117	143152	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	466	2	3	5	1.3	C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3900193	143152	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	466	2	3	5	1.3	C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	57722068	143401	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	478	3	3	6	0.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCOCCOCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3902231	143401	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	478	3	3	6	0.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCOCCOCCN[C@@H](C2CC2)C(=O)N1C	nan
	134135595	143432	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	4	4	5	5.1	CC(C)C[C@@H]1NCc2ccccc2Sc2ccccc2CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3902597	143432	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	4	4	5	5.1	CC(C)C[C@@H]1NCc2ccccc2Sc2ccccc2CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134139160	145676	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	560	4	3	5	3.7	CC(C)C[C@H]1C(=O)NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN1C	nan
	CHEMBL3920156	145676	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	560	4	3	5	3.7	CC(C)C[C@H]1C(=O)NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN1C	nan
	134140250	145713	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	562	5	4	5	3.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](CCc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3920479	145713	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	562	5	4	5	3.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](CCc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	57951693	145744	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	nan
	CHEMBL3920711	145744	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	nan
	134140177	145837	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC(C)C[C@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3921493	145837	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC(C)C[C@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134139639	146106	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	6	4	7	2.5	CCOC(=O)CC[C@@H]1NC(=O)C2(CCCC2)NC(=O)[C@H](CC(C)C)NCCOc2ccccc2/C=C\CNC1=O	nan
	CHEMBL3923467	146106	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	6	4	7	2.5	CCOC(=O)CC[C@@H]1NC(=O)C2(CCCC2)NC(=O)[C@H](CC(C)C)NCCOc2ccccc2/C=C\CNC1=O	nan
	134140216	146111	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	587	4	5	5	3.8	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3923508	146111	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	587	4	5	5	3.8	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2(CCCC2)NC1=O	nan
	134141155	146195	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	6	3.3	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3924187	146195	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	6	3.3	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCOC2)NC1=O	nan
	134137626	146950	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	5	6	3.0	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3930400	146950	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	5	6	3.0	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134148332	147749	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2ncccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3936664	147749	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2ncccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	57528213	147952	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	5	2.9	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	nan
	CHEMBL3938163	147952	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	5	2.9	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	nan
	134149424	148104	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](C(C)c2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3939431	148104	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](C(C)c2ccccc2)NC(=O)CN(C)C1=O	nan
	57951672	149062	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	CHEMBL3946954	149062	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	134147008	149404	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	4	5	2.8	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	CHEMBL3949653	149404	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	4	5	2.8	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	134155726	150486	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	478	3	3	6	0.2	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NCCOCCOCCNC(C2CC2)C(=O)N1C	nan
	CHEMBL3958492	150486	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	478	3	3	6	0.2	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NCCOCCOCCNC(C2CC2)C(=O)N1C	nan
	134155844	150556	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	570	6	4	5	3.3	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC1=O	nan
	CHEMBL3959055	150556	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	570	6	4	5	3.3	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC1=O	nan
	57528307	150595	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	nan
	CHEMBL3959346	150595	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	nan
	134156186	150818	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	490	4	4	4	3.1	CC[C@H](C)[C@@H]1NCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3961157	150818	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	490	4	4	4	3.1	CC[C@H](C)[C@@H]1NCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134150525	151032	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	551	8	5	6	2.2	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O	nan
	CHEMBL3963236	151032	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	551	8	5	6	2.2	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O	nan
	134149894	151302	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc(Cl)cc1	nan
	CHEMBL3965402	151302	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc(Cl)cc1	nan
	134150119	151515	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	6	4	6	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](COC(C)(C)C)NC1=O	nan
	CHEMBL3967266	151515	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	6	4	6	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](COC(C)(C)C)NC1=O	nan
	134150914	151548	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	6	3	5	3.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]([C@H](C)CC)N(C)C1=O	nan
	CHEMBL3967522	151548	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	6	3	5	3.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]([C@H](C)CC)N(C)C1=O	nan
	57722047	152334	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	436	4	3	4	1.8	CCC[C@@H]1NCc2cccc(c2)CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3974323	152334	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	436	4	3	4	1.8	CCC[C@@H]1NCc2cccc(c2)CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	57951687	152339	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	nan
	CHEMBL3974356	152339	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	nan
	57528291	152383	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	5	2.9	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	nan
	CHEMBL3974776	152383	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	5	2.9	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	nan
	134152485	152642	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	604	5	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(C(=O)O)cc2)NC(=O)C2(CCCC2)N(C)C1=O	nan
	CHEMBL3976941	152642	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	604	5	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(C(=O)O)cc2)NC(=O)C2(CCCC2)N(C)C1=O	nan
	134151873	152666	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	4	5	4.7	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccc2ccccc12	nan
	CHEMBL3977166	152666	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	4	5	4.7	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccc2ccccc12	nan
	76556607	153021	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CCC(C)C1NCCOc2ccccc2CCCNC(=O)C(Cc2ccccc2)N2CCC(C2=O)N(C)C1=O	nan
	CHEMBL3980176	153021	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CCC(C)C1NCCOc2ccccc2CCCNC(=O)C(Cc2ccccc2)N2CCC(C2=O)N(C)C1=O	nan
	134157812	153136	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	4	5	2.1	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	CHEMBL3981235	153136	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	4	5	2.1	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	134156737	153165	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	547	4	4	6	2.8	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccncc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3981446	153165	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	547	4	4	6	2.8	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccncc2)NC(=O)C2(CCCC2)NC1=O	nan
	134156806	153560	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	6	4	5	3.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)NC1=O	nan
	CHEMBL3984892	153560	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	6	4	5	3.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)NC1=O	nan
	134157124	153672	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	492	2	4	5	1.9	O=C1CNCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)N1	nan
	CHEMBL3985913	153672	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	492	2	4	5	1.9	O=C1CNCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)N1	nan
	11706547	68704	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	540	3	3	5	2.8	CC(C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923619	68704	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	540	3	3	5	2.8	CC(C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	134138625	147498	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	3	3	5	1.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3934561	147498	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	3	3	5	1.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	44434011	147331	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	465	12	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL393321	147331	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	465	12	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1	10.1016/j.bmcl.2007.07.099
	70692601	75522	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	481	7	0	7	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048814	75522	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	481	7	0	7	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	127046957	139177	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798155	139177	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	127046472	139164	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798056	139164	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	56926266	68674	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	523	6	4	6	1.4	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCCN)C1=O	10.1021/jm2007062
	CHEMBL1923508	68674	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	523	6	4	6	1.4	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCCN)C1=O	10.1021/jm2007062
	73352329	91833	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426669	91833	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	70692602	75523	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	423	8	0	5	3.5	CCCOc1ccc(CN2CC3(CCN(C(=O)Cc4ccc(OC)cc4)CC3)C2)cn1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048815	75523	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	423	8	0	5	3.5	CCCOc1ccc(CN2CC3(CCN(C(=O)Cc4ccc(OC)cc4)CC3)C2)cn1	10.1016/j.bmcl.2012.05.024
	162665974	181653	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	612	13	3	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4783347	181653	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	612	13	3	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	44396381	67191	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	558	13	2	3	6.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NCc1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm040103i
	CHEMBL189625	67191	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	558	13	2	3	6.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NCc1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm040103i
	44396377	66609	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	532	13	2	4	5.8	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(Cc1ccc(C)o1)C(=O)NC1CCCCC1	10.1021/jm040103i
	CHEMBL186647	66609	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	532	13	2	4	5.8	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(Cc1ccc(C)o1)C(=O)NC1CCCCC1	10.1021/jm040103i
	44396269	67019	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	426	10	2	3	4.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C)C(=O)NC(C)(C)C	10.1021/jm040103i
	CHEMBL188586	67019	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	426	10	2	3	4.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C)C(=O)NC(C)(C)C	10.1021/jm040103i
	56926895	68723	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	3.0	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OC(C)(C)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923639	68723	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	3.0	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OC(C)(C)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	56942244	124677	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645259	124677	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	162648546	179298	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	13	3	6	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC=O)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4745666	179298	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	13	3	6	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC=O)cc1	10.1021/acs.jmedchem.9b02122
	58438460	111246	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL3287217	111246	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml400473x
	56926356	68677	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923512	68677	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	56926176	68672	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923505	68672	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	71453390	81431	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	526	6	2	4	4.4	C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164500	81431	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	526	6	2	4	4.4	C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	162663952	181570	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	636	13	2	7	6.6	COc1ccc(/C=C(\C#N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4782383	181570	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	636	13	2	7	6.6	COc1ccc(/C=C(\C#N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	118725963	116692	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	541	7	1	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	CHEMBL3394203	116692	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	541	7	1	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	44434112	168294	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL438154	168294	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	3174463	66435	3	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	532	12	2	3	6.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
	CHEMBL185876	66435	3	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	532	12	2	3	6.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
	56926464	68697	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	nan
	CHEMBL1923612	68697	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	nan
	118725960	116688	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	507	5	0	6	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C#N)c1	10.1021/ml500414n
	CHEMBL3394199	116688	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	507	5	0	6	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C#N)c1	10.1021/ml500414n
	162657547	180401	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	694	15	2	9	6.2	COc1ccc(/C=C(\C#N)C(=O)OCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4758721	180401	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	694	15	2	9	6.2	COc1ccc(/C=C(\C#N)C(=O)OCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	162658148	180566	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	565	13	4	7	3.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CN)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4760746	180566	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	565	13	4	7	3.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CN)cc1	10.1021/acs.jmedchem.9b02122
	162662164	180828	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	636	12	3	6	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4763700	180828	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	636	12	3	6	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	127047362	139189	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798204	139189	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	3154000	123751	5	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	530	12	3	4	5.8	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(O)cc1	10.1021/jm040103i
	CHEMBL363467	123751	5	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	530	12	3	4	5.8	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(O)cc1	10.1021/jm040103i
	162651277	179616	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	598	14	3	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNCc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4749525	179616	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	598	14	3	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNCc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	3180629	67016	5	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	518	11	2	3	5.8	CCN(CC)CCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
	CHEMBL188582	67016	5	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	518	11	2	3	5.8	CCN(CC)CCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
	44434016	89762	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	415	12	3	7	1.5	CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL238228	89762	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	415	12	3	7	1.5	CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	72190452	91846	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426682	91846	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	118725964	116693	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	7	1	6	4.1	COc1ccc(CCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	CHEMBL3394204	116693	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	7	1	6	4.1	COc1ccc(CCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	70692600	75521	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	447	7	0	7	2.8	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048813	75521	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	447	7	0	7	2.8	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	70682036	75525	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	446	7	1	4	4.3	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4n[nH]c5ccccc45)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048817	75525	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	446	7	1	4	4.3	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4n[nH]c5ccccc45)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	70686293	75530	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	472	5	0	7	3.8	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-c5ncccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048822	75530	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	472	5	0	7	3.8	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-c5ncccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	58438460	111246	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml500414n
	CHEMBL3287217	111246	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml500414n
	162660604	180637	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	700	15	3	9	5.0	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4761319	180637	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	700	15	3	9	5.0	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	162671996	182249	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	707	16	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4791255	182249	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	707	16	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	25032438	115696	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human ghrelin receptor by receptor binding assayBinding affinity to human ghrelin receptor by receptor binding assay	ChEMBL	485	14	2	6	3.8	CCN(CC)CCCS(=O)(=O)N[C@H](CCc1ccccc1)c1nc(-c2ccc(OC)cc2)n[nH]1	10.1021/jm5003183
	CHEMBL3358450	115696	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human ghrelin receptor by receptor binding assayBinding affinity to human ghrelin receptor by receptor binding assay	ChEMBL	485	14	2	6	3.8	CCN(CC)CCCS(=O)(=O)N[C@H](CCc1ccccc1)c1nc(-c2ccc(OC)cc2)n[nH]1	10.1021/jm5003183
	11692516	68706	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	554	3	3	5	3.1	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923621	68706	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	554	3	3	5	3.1	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	67407161	91852	0	None	1819	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	467	5	0	5	4.3	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426688	91852	0	None	1819	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	467	5	0	5	4.3	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	67410074	111245	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL3287216	111245	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)nc1	10.1021/ml400473x
	56926782	68715	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923631	68715	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	70696687	75520	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	446	7	0	6	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4cccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048812	75520	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	446	7	0	6	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4cccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	127046806	139403	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799604	139403	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127048038	139442	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799862	139442	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	44434076	89347	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	513	10	2	9	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21	10.1016/j.bmcl.2007.07.099
	CHEMBL237717	89347	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	513	10	2	9	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21	10.1016/j.bmcl.2007.07.099
	56926463	68696	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923611	68696	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	11526696	71258	13	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923502	71258	13	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1963249	71258	13	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	72191051	91830	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	456	5	0	6	3.4	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426666	91830	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	456	5	0	6	3.4	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	58438460	111246	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL3287217	111246	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml400473x
	56926783	68716	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	470	4	3	4	2.8	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923632	68716	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	470	4	3	4	2.8	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	162658631	180501	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	561	12	3	7	3.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C#N)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4759983	180501	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	561	12	3	7	3.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C#N)cc1	10.1021/acs.jmedchem.9b02122
	118725958	116687	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	507	4	0	7	3.9	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4nn(C)c5ncccc45)CC3)C2)ncn1	10.1021/ml500414n
	CHEMBL3394197	116687	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	507	4	0	7	3.9	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4nn(C)c5ncccc45)CC3)C2)ncn1	10.1021/ml500414n
	162659337	180734	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	665	15	3	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C#N)Cc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4762631	180734	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	665	15	3	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C#N)Cc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	73355325	91835	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426671	91835	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	70696688	75526	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	487	9	0	6	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cn1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048818	75526	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	487	9	0	6	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cn1	10.1016/j.bmcl.2012.05.024
	127048060	139331	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	789	20	6	10	5.4	COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799222	139331	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	789	20	6	10	5.4	COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	56942388	139413	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799687	139413	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	162677361	182927	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	685	16	4	8	4.7	COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4799766	182927	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	685	16	4	8	4.7	COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	58438475	91841	0	None	1548	2	Human	7.8	pKi	=	7.8	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml400473x
	CHEMBL2426677	91841	0	None	1548	2	Human	7.8	pKi	=	7.8	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml400473x
	44434109	145748	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	529	13	2	9	1.8	CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL392076	145748	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	529	13	2	9	1.8	CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	134139080	147150	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	CHEMBL3931856	147150	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	44434010	88345	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL236311	88345	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	127047655	139084	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797531	139084	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	44340007	9224	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	541	9	2	6	2.0	CN1N=C2CCN(C(=O)[C@@H](COCc3ccc(F)c(F)c3)NC(=O)C(C)(C)N)CC2(Cc2ccccc2)C1=O	10.1016/s0960-894x(02)00734-5
	CHEMBL111026	9224	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	541	9	2	6	2.0	CN1N=C2CCN(C(=O)[C@@H](COCc3ccc(F)c(F)c3)NC(=O)C(C)(C)N)CC2(Cc2ccccc2)C1=O	10.1016/s0960-894x(02)00734-5
	56925344	68725	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923641	68725	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	44434083	89600	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL238155	89600	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1	10.1016/j.bmcl.2007.07.099
	44434050	144917	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL391428	144917	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1	10.1016/j.bmcl.2007.07.099
	44396306	66941	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	452	11	2	3	4.7	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C)C(=O)NC1CCCCC1	10.1021/jm040103i
	CHEMBL188173	66941	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	452	11	2	3	4.7	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C)C(=O)NC1CCCCC1	10.1021/jm040103i
	145948725	166936	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	885	20	7	9	6.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL4299615	166936	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	885	20	7	9	6.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	57345597	70926	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2ccc(Oc3ccc(F)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956988	70926	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2ccc(Oc3ccc(F)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	56942243	124676	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645258	124676	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	162648837	179258	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	706	15	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4745116	179258	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	706	15	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	127048059	139036	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	675	16	6	8	4.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797225	139036	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	675	16	6	8	4.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	11526745	68726	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923642	68726	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	57400003	70935	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	461	5	0	7	4.7	Cc1nc2ccc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956996	70935	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	461	5	0	7	4.7	Cc1nc2ccc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	155529391	170874	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1427	41	20	17	-3.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4463042	170874	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1427	41	20	17	-3.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	70690449	75518	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	486	9	0	5	4.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048810	75518	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	486	9	0	5	4.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	118725965	116694	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	6	1	6	4.0	CNC(=O)c1cc(OC)ccc1CC(=O)N1CCC2(CC1)CN([C@@H]1CCc3cc(-c4cc(C)ncn4)ccc31)C2	10.1021/ml500414n
	CHEMBL3394205	116694	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	6	1	6	4.0	CNC(=O)c1cc(OC)ccc1CC(=O)N1CCC2(CC1)CN([C@@H]1CCc3cc(-c4cc(C)ncn4)ccc31)C2	10.1021/ml500414n
	44434080	89481	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL237933	89481	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	162647450	179291	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	12	2	6	4.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4745548	179291	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	12	2	6	4.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C)cc1	10.1021/acs.jmedchem.9b02122
	71456910	81489	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	480	5	2	4	3.6	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164823	81489	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	480	5	2	4	3.6	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	3154005	66440	4	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	550	13	1	4	5.7	CCN(CC)CCCN(C(=O)CCN1CCCc2ccccc21)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
	CHEMBL185887	66440	4	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	550	13	1	4	5.7	CCN(CC)CCCN(C(=O)CCN1CCCc2ccccc21)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
	70696689	75529	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	460	5	0	7	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5cccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048821	75529	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	460	5	0	7	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5cccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	56926681	68709	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2cccc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923624	68709	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2cccc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	127047409	139101	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	888	24	8	10	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797639	139101	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	888	24	8	10	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	56926785	68718	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923634	68718	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	70688404	75514	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1021/ml400473x
	CHEMBL2048807	75514	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1021/ml400473x
	44434009	166893	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	431	13	3	8	1.1	CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL429799	166893	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	431	13	3	8	1.1	CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	53248756	60853	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Inhibition of [125I]Ghrelin binding to human Ghrelin receptor expressed in CHO-K1 cells after 60 mins by liquid scintillation spectrometryInhibition of [125I]Ghrelin binding to human Ghrelin receptor expressed in CHO-K1 cells after 60 mins by liquid scintillation spectrometry	ChEMBL	457	5	0	5	5.6	Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C)C1	10.1016/j.bmc.2011.02.021
	CHEMBL1765654	60853	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Inhibition of [125I]Ghrelin binding to human Ghrelin receptor expressed in CHO-K1 cells after 60 mins by liquid scintillation spectrometryInhibition of [125I]Ghrelin binding to human Ghrelin receptor expressed in CHO-K1 cells after 60 mins by liquid scintillation spectrometry	ChEMBL	457	5	0	5	5.6	Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C)C1	10.1016/j.bmc.2011.02.021
	CHEMBL2170701	207616	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	10253999	123276	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	466	12	2	3	5.1	CCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
	CHEMBL362303	123276	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	466	12	2	3	5.1	CCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
	127048061	139206	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	903	24	7	11	5.9	COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798337	139206	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	903	24	7	11	5.9	COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	162662593	181388	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	591	12	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN2CCC(N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4780100	181388	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	591	12	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN2CCC(N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	44579909	186320	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL489819	186320	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	44434073	89170	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL237507	89170	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	70694649	75531	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	475	5	0	7	3.2	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-n3nccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	CHEMBL2048823	75531	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	475	5	0	7	3.2	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-n3nccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	162659161	180809	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	642	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4763471	180809	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	642	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	162652815	179795	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	564	14	2	6	5.3	CCN(CC)CC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4751674	179795	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	564	14	2	6	5.3	CCN(CC)CC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL2170779	207621	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44434008	146001	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	404	11	2	9	0.7	COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL392268	146001	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	404	11	2	9	0.7	COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	44434110	88084	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	515	13	3	9	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL235135	88084	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	515	13	3	9	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44577060	187469	0	None	-69	7	Human	6.6	pKi	=	6.6	Binding	Inhibition of ghrelin receptorInhibition of ghrelin receptor	ChEMBL	530	10	1	4	4.8	CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	CHEMBL497746	187469	0	None	-69	7	Human	6.6	pKi	=	6.6	Binding	Inhibition of ghrelin receptorInhibition of ghrelin receptor	ChEMBL	530	10	1	4	4.8	CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	CHEMBL2170780	207622	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	71453404	81491	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164826	81491	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	70692603	75524	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	463	7	0	5	5.0	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4nc5ccccc5s4)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048816	75524	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	463	7	0	5	5.0	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4nc5ccccc5s4)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	56926360	68693	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	522	4	3	5	2.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923608	68693	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	522	4	3	5	2.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	72190451	91844	0	None	524	2	Human	7.6	pKi	=	7.6	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL2426680	91844	0	None	524	2	Human	7.6	pKi	=	7.6	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1021/ml400473x
	44579907	186465	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL491044	186465	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	73350846	91834	0	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426670	91834	0	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	44576247	212451	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.1c02191
	CHEMBL506986	212451	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.1c02191
	44576247	212451	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1016/j.bmcl.2016.04.003
	CHEMBL506986	212451	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1016/j.bmcl.2016.04.003
	44579880	186253	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL489401	186253	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	118725962	116691	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	526	6	1	7	3.1	COc1cc(C(N)=O)c(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)cn1	10.1021/ml500414n
	CHEMBL3394202	116691	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	526	6	1	7	3.1	COc1cc(C(N)=O)c(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)cn1	10.1021/ml500414n
	44396384	67071	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	574	14	2	5	6.1	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(OC)c(OC)c1	10.1021/jm040103i
	CHEMBL188839	67071	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	574	14	2	5	6.1	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(OC)c(OC)c1	10.1021/jm040103i
	44434074	154135	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL399625	154135	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	70684155	75532	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	486	5	0	6	4.1	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-c3ncccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	CHEMBL2048824	75532	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	486	5	0	6	4.1	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-c3ncccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	72191050	91831	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	453	4	0	5	4.0	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426667	91831	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	453	4	0	5	4.0	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	72190449	91840	0	None	4	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426676	91840	0	None	4	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	118725966	116695	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	6	1	6	4.6	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(NC(C)=O)c1	10.1021/ml500414n
	CHEMBL3394206	116695	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	6	1	6	4.6	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(NC(C)=O)c1	10.1021/ml500414n
	162675268	182776	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	645	13	3	8	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2(C#N)CCOCC2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4797685	182776	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	645	13	3	8	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2(C#N)CCOCC2)cc1	10.1021/acs.jmedchem.9b02122
	3153999	126310	3	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	494	14	2	3	5.9	CCCCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
	CHEMBL365489	126310	3	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	494	14	2	3	5.9	CCCCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
	71451551	81439	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	460	5	2	4	3.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164508	81439	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	460	5	2	4	3.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1	10.1016/j.bmc.2012.07.018
	72190451	91844	0	None	524	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426680	91844	0	None	524	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	72190451	91844	0	None	524	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL2426680	91844	0	None	524	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1021/ml400473x
	9950632	88278	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL236038	88278	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2007.07.099
	127046472	139164	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	CHEMBL3798056	139164	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	127045859	139169	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL	831	20	7	9	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CO)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	CHEMBL3798095	139169	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL	831	20	7	9	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CO)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	127045859	139169	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	831	20	7	9	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CO)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798095	139169	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	831	20	7	9	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CO)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	127047523	139533	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	859	20	7	9	6.0	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3800422	139533	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	859	20	7	9	6.0	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1	10.1016/j.bmcl.2016.04.003
	71456897	81438	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	513	5	2	3	5.7	CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164507	81438	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	513	5	2	3	5.7	CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	162653916	179963	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	707	15	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753794	179963	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	707	15	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	162643920	181198	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	679	14	4	8	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4777792	181198	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	679	14	4	8	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	155537651	171750	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1597	47	22	19	-3.8	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4475293	171750	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1597	47	22	19	-3.8	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	57391292	70934	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	473	6	0	8	4.6	COc1ccc2cccc(Oc3ccc4nc(C)n(C[C@H]5CCCN(C(C)C)C5)c(=O)c4n3)c2n1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956995	70934	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	473	6	0	8	4.6	COc1ccc2cccc(Oc3ccc4nc(C)n(C[C@H]5CCCN(C(C)C)C5)c(=O)c4n3)c2n1	10.1016/j.bmcl.2012.01.078
	57345598	70943	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	411	5	0	7	3.5	Cc1nc2ncc(Oc3ccc(F)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957004	70943	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	411	5	0	7	3.5	Cc1nc2ncc(Oc3ccc(F)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	53373577	91850	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	458	5	0	7	2.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426686	91850	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	458	5	0	7	2.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	57391294	70937	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2cnc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956998	70937	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2cnc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	155526063	170469	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1174	34	16	14	-2.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4456830	170469	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1174	34	16	14	-2.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	162663004	181467	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	603	13	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C)(C)C#N)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4781141	181467	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	603	13	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C)(C)C#N)cc1	10.1021/acs.jmedchem.9b02122
	155557019	174015	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174015	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	71453489	207623	13	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.8b01644
	CHEMBL2170781	207623	13	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.8b01644
	67405379	91847	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426683	91847	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	25211977	186319	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	372	7	1	3	3.9	C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL489818	186319	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	372	7	1	3	3.9	C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	25098836	190862	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL519322	190862	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	127047525	139237	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	858	20	7	9	5.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798559	139237	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	858	20	7	9	5.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	162653309	179891	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	718	14	5	8	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4752936	179891	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	718	14	5	8	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44579756	186241	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL489370	186241	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	162666964	181928	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	13	3	6	4.6	CCNCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4787023	181928	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	13	3	6	4.6	CCNCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL2170693	207608	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44434121	89478	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL237927	89478	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N	10.1016/j.bmcl.2007.07.099
	56926584	68705	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	554	4	3	5	3.2	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923620	68705	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	554	4	3	5	3.2	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	44434120	89477	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	523	15	3	9	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL237926	89477	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	523	15	3	9	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1	10.1016/j.bmcl.2007.07.099
	44434007	88147	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	390	10	2	9	0.3	COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL235446	88147	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	390	10	2	9	0.3	COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	11541143	68703	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	540	4	3	5	3.0	CCC[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923618	68703	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	540	4	3	5	3.0	CCC[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	24969520	68707	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	3	3	5	2.5	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923622	68707	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	3	3	5	2.5	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL2170694	207609	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	56926580	68699	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	536	5	4	5	3.1	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC)NC1=O	10.1021/jm2007062
	CHEMBL1923614	68699	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	536	5	4	5	3.1	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC)NC1=O	10.1021/jm2007062
	162653802	179949	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	656	15	4	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753592	179949	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	656	15	4	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	73346226	91832	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	487	8	0	7	3.4	COCC(c1ccc(-c2ncccn2)cc1)N1CC2(CCN(C(=O)Cc3ccc(OC)cn3)CC2)C1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426668	91832	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	487	8	0	7	3.4	COCC(c1ccc(-c2ncccn2)cc1)N1CC2(CCN(C(=O)Cc3ccc(OC)cn3)CC2)C1	10.1016/j.bmcl.2013.07.044
	162674738	182805	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	638	14	3	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4797988	182805	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	638	14	3	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	56926177	68673	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923506	68673	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	56926581	68700	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	5	4	5	3.4	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC1=O	10.1021/jm2007062
	CHEMBL1923615	68700	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	5	4	5	3.4	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC1=O	10.1021/jm2007062
	71458747	81426	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2012.07.018
	CHEMBL2164494	81426	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2012.07.018
	23631116	4049	19	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	10.1016/j.bmcl.2012.01.078
	3538	4049	19	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	10.1016/j.bmcl.2012.01.078
	CHEMBL243001	4049	19	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	10.1016/j.bmcl.2012.01.078
	127046956	139427	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799776	139427	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	118725961	116689	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	523	6	0	7	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C#N)c1	10.1021/ml500414n
	CHEMBL3394200	116689	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	523	6	0	7	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C#N)c1	10.1021/ml500414n
	162663407	181448	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	562	13	3	6	4.3	C=CC(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4780843	181448	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	562	13	3	6	4.3	C=CC(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	56926462	68695	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923610	68695	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	70695747	72844	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]Ghrelin from human GHSR1a receptorDisplacement of [125I]Ghrelin from human GHSR1a receptor	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011816	72844	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]Ghrelin from human GHSR1a receptorDisplacement of [125I]Ghrelin from human GHSR1a receptor	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	67406334	111242	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	498	4	0	7	4.3	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ncccn6)ccc53)C4)nc2s1	10.1021/ml400473x
	CHEMBL3287213	111242	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	498	4	0	7	4.3	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ncccn6)ccc53)C4)nc2s1	10.1021/ml400473x
	57390496	68713	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	CHEMBL1923628	68713	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	71453489	207623	13	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	207623	13	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	56926269	68676	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	460	5	3	5	2.0	CCCC[C@H]1NC(=O)CN(C)C(=O)[C@H](CCC)NCCOc2ccccc2CCCNC1=O	10.1021/jm2007062
	CHEMBL1923511	68676	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	460	5	3	5	2.0	CCCC[C@H]1NC(=O)CN(C)C(=O)[C@H](CCC)NCCOc2ccccc2CCCNC1=O	10.1021/jm2007062
	56926784	68717	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923633	68717	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	70688404	75514	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1021/ml400473x
	CHEMBL2048807	75514	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1021/ml400473x
	70688404	75514	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048807	75514	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2012.05.024
	44434123	145017	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL391510	145017	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N	10.1016/j.bmcl.2007.07.099
	56926582	68701	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923616	68701	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	16114404	154358	18	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL400814	154358	18	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/acs.jmedchem.9b02122
	25190383	81497	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164831	81497	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	11683187	198250	35	None	-457	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity to ghrelin receptorBinding affinity to ghrelin receptor	ChEMBL	419	7	0	8	2.9	COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1	10.1016/j.bmcl.2009.11.097
	CHEMBL594828	198250	35	None	-457	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity to ghrelin receptorBinding affinity to ghrelin receptor	ChEMBL	419	7	0	8	2.9	COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1	10.1016/j.bmcl.2009.11.097
	70684154	75516	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	414	6	0	4	3.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048809	75516	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	414	6	0	4	3.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	44434055	88875	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL236858	88875	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	56942385	124678	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645260	124678	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	56942535	139231	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798525	139231	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	24180592	96565	0	None	-134	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	CHEMBL266647	96565	0	None	-134	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	44434113	88221	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL235793	88221	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	44434051	88985	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237058	88985	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	118725954	116685	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	467	4	0	5	4.3	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml500414n
	CHEMBL3394193	116685	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	467	4	0	5	4.3	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml500414n
	24969603	68712	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	3	3	5	2.4	Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1	10.1021/jm2007062
	CHEMBL1923627	68712	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	3	3	5	2.4	Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1	10.1021/jm2007062
	57394882	70950	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	447	5	0	9	3.3	Cc1nc2ncc(Oc3ccc4c(c3)ncn4C)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957011	70950	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	447	5	0	9	3.3	Cc1nc2ncc(Oc3ccc4c(c3)ncn4C)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	9876514	9052	2	None	-	1	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	610	10	2	7	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)[C@]2(Cc2ccccn2)C1	10.1016/s0960-894x(02)00734-5
	CHEMBL109980	9052	2	None	-	1	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	610	10	2	7	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)[C@]2(Cc2ccccn2)C1	10.1016/s0960-894x(02)00734-5
	70682037	75528	14	None	43	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2013.07.044
	CHEMBL2048820	75528	14	None	43	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2013.07.044
	145948708	166935	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	886	20	7	10	5.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL4299606	166935	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	886	20	7	10	5.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	67410074	111245	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL3287216	111245	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)nc1	10.1021/ml400473x
	56926465	68698	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	10.1021/jm2007062
	CHEMBL1923613	68698	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	10.1021/jm2007062
	44434119	89476	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	400	10	3	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1	10.1016/j.bmcl.2007.07.099
	CHEMBL237925	89476	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	400	10	3	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1	10.1016/j.bmcl.2007.07.099
	70694648	75519	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	462	7	0	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4nnc(C)o4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048811	75519	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	462	7	0	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4nnc(C)o4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	155561671	175091	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	817	22	11	9	-0.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4581511	175091	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	817	22	11	9	-0.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	56926894	68722	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923638	68722	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	162672372	182504	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	656	14	3	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4794448	182504	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	656	14	3	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	56925345	68727	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923643	68727	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	56926464	68697	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923612	68697	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	10.1021/jm2007062
	56942387	139132	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797857	139132	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL105462	206726	34	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm960054c
	56926680	68708	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923623	68708	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	162649014	179361	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	702	14	4	7	6.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4746362	179361	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	702	14	4	7	6.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1	10.1021/acs.jmedchem.9b02122
	162666112	181732	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	638	13	3	8	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccc(C#N)nc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4784240	181732	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	638	13	3	8	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccc(C#N)nc2)cc1	10.1021/acs.jmedchem.9b02122
	162676229	182722	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	715	15	3	10	3.9	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4797064	182722	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	715	15	3	10	3.9	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	58438475	91841	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426677	91841	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	58438475	91841	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml400473x
	CHEMBL2426677	91841	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml400473x
	56926461	68694	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923609	68694	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	118725956	116686	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	493	5	0	5	4.9	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4ccc(C5CC5)cn4)CC3)C2)ncn1	10.1021/ml500414n
	CHEMBL3394195	116686	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	493	5	0	5	4.9	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4ccc(C5CC5)cn4)CC3)C2)ncn1	10.1021/ml500414n
	155551597	173377	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	974	27	13	11	-1.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4541252	173377	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	974	27	13	11	-1.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	57394797	70941	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	461	5	0	7	4.7	Cc1nc2cnc(Oc3ccc(F)c4cccnc34)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957002	70941	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	461	5	0	7	4.7	Cc1nc2cnc(Oc3ccc(F)c4cccnc34)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	162649450	179474	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	725	14	3	10	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4747770	179474	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	725	14	3	10	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	58438464	3016	28	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	9060	3016	28	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	CHEMBL3287218	3016	28	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	DB14870	3016	28	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	58438464	3016	28	None	1	3	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	9060	3016	28	None	1	3	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	CHEMBL3287218	3016	28	None	1	3	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	DB14870	3016	28	None	1	3	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	67406334	111242	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	498	4	0	7	4.3	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ncccn6)ccc53)C4)nc2s1	10.1021/ml400473x
	CHEMBL3287213	111242	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	498	4	0	7	4.3	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ncccn6)ccc53)C4)nc2s1	10.1021/ml400473x
	57401798	70927	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2ncc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956989	70927	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2ncc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	58438475	91841	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml500414n
	CHEMBL2426677	91841	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml500414n
	11541319	68728	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	556	3	3	5	2.7	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2O1	10.1021/jm2007062
	CHEMBL1923644	68728	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	556	3	3	5	2.7	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2O1	10.1021/jm2007062
	162659375	180769	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	566	14	4	7	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNCC(=O)O)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4763077	180769	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	566	14	4	7	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNCC(=O)O)cc1	10.1021/acs.jmedchem.9b02122
	127046807	139410	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799671	139410	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127047654	139447	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799883	139447	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	121879	2204	19	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm960054c
	5868	2204	19	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm960054c
	CHEMBL308716	2204	19	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm960054c
	162665952	181797	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	688	14	4	10	3.5	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4785149	181797	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	688	14	4	10	3.5	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	134139753	145503	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	5	3	5	2.5	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3918783	145503	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	5	3	5	2.5	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	162663868	181406	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	672	14	3	9	3.8	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4780408	181406	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	672	14	3	9	3.8	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	56926268	68675	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	4	3	5	2.5	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](Cc2ccccc2)C1=O	10.1021/jm2007062
	CHEMBL1923510	68675	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	4	3	5	2.5	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](Cc2ccccc2)C1=O	10.1021/jm2007062
	56926175	68671	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923504	68671	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	23635235	165948	0	None	-239	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of ghrelin receptorInhibition of ghrelin receptor	ChEMBL	526	10	1	4	4.9	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmc.2008.03.072
	CHEMBL427860	165948	0	None	-239	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of ghrelin receptorInhibition of ghrelin receptor	ChEMBL	526	10	1	4	4.9	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmc.2008.03.072
	70686292	75527	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	461	5	0	8	3.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048819	75527	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	461	5	0	8	3.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	90644554	111244	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ccncn5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL3287215	111244	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ccncn5)ccc42)C3)nc1	10.1021/ml400473x
	70682037	75528	14	None	43	2	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048820	75528	14	None	43	2	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	11664206	68711	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923626	68711	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	216208	9635	27	None	-	1	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1016/s0960-894x(02)00734-5
	CHEMBL113313	9635	27	None	-	1	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1016/s0960-894x(02)00734-5
	56926682	68710	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923625	68710	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	67408128	91848	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	5	0	6	3.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426684	91848	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	5	0	6	3.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	24180646	147650	0	None	-1023	7	Human	6.1	pKi	=	6.1	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
	CHEMBL393576	147650	0	None	-1023	7	Human	6.1	pKi	=	6.1	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
	57390496	68713	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	CHEMBL1923628	68713	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	CHEMBL501261	212364	19	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.8b01644
	56926892	68720	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923636	68720	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	44434012	88645	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	479	13	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL236513	88645	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	479	13	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	127046473	139250	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	661	17	6	8	4.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798645	139250	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	661	17	6	8	4.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	56942099	124674	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645256	124674	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	66601728	81429	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	514	5	2	4	4.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164499	81429	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	514	5	2	4	4.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	162657465	180459	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	652	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4759418	180459	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	652	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1	10.1021/acs.jmedchem.9b02122
	56926891	68719	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923635	68719	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	44434015	88063	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL235011	88063	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	67407808	91851	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL2426687	91851	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1021/ml400473x
	56926173	68670	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923501	68670	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	3153998	67181	3	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	480	13	2	3	5.5	CCCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
	CHEMBL189561	67181	3	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	480	13	2	3	5.5	CCCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
	56926893	68721	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	10.1021/jm2007062
	CHEMBL1923637	68721	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	10.1021/jm2007062
	66788278	124672	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645254	124672	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127045858	139332	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799225	139332	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	162677268	182991	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	663	14	3	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4800459	182991	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	663	14	3	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	58438487	91849	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	497	6	0	6	4.3	CCc1cnc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4ccc(OC)cn4)CC3)C2)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426685	91849	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	497	6	0	6	4.3	CCc1cnc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4ccc(OC)cn4)CC3)C2)nc1	10.1016/j.bmcl.2013.07.044
	67407808	91851	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426687	91851	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	67407808	91851	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL2426687	91851	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1021/ml400473x
	67406727	116690	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	525	6	1	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	CHEMBL3394201	116690	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	525	6	1	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	162656896	180278	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	669	14	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4757313	180278	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	669	14	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1	10.1021/acs.jmedchem.9b02122
	44579823	183499	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL482420	183499	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	44396320	66483	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	515	12	2	4	5.4	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccncc1	10.1021/jm040103i
	CHEMBL186045	66483	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	515	12	2	4	5.4	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccncc1	10.1021/jm040103i
	162674996	182807	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	522	12	3	6	4.2	CNCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4798018	182807	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	522	12	3	6	4.2	CNCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	44434111	145750	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL392077	145750	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	9745	2420	20	None	-	0	Human	8.1	pIC50	=	8.1	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Drug Central	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	None
	9804938	2420	20	None	-	0	Human	8.1	pIC50	=	8.1	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Drug Central	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	None
	CHEMBL278623	2420	20	None	-	0	Human	8.1	pIC50	=	8.1	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Drug Central	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	None
	DB13074	2420	20	None	-	0	Human	8.1	pIC50	=	8.1	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Drug Central	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	None
	9745	2420	20	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Guide to Pharmacology	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	12240910
	9804938	2420	20	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Guide to Pharmacology	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	12240910
	CHEMBL278623	2420	20	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Guide to Pharmacology	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	12240910
	DB13074	2420	20	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Guide to Pharmacology	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	12240910
	1102	1294	0	None	-	1	Human	7.4	pKd	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12907757
	1093	1764	0	None	-12	2	Human	7.7	pKd	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	1093	1764	0	None	-12	2	Human	7.7	pKd	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	4345065	1764	0	None	-12	2	Human	7.7	pKd	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	4345065	1764	0	None	-12	2	Human	7.7	pKd	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	1100	1578	41	None	-	1	Human	7.9	pKd	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11061542
	6918297	1578	41	None	-	1	Human	7.9	pKd	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11061542
	CHEMBL108335	1578	41	None	-	1	Human	7.9	pKd	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11061542
	1099	1757	0	None	-	1	Human	9.0	pKd	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12907757
	1099	1757	0	None	-	1	Human	9.0	pKd	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	1092	3109	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
	134715446	3109	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
	2232	3109	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
	6918245	3109	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
	CHEMBL106593	3109	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
	58438464	3016	28	None	-2	3	Mouse	8.1	pKi	=	8.1	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	9060	3016	28	None	-2	3	Mouse	8.1	pKi	=	8.1	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	CHEMBL3287218	3016	28	None	-2	3	Mouse	8.1	pKi	=	8.1	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	DB14870	3016	28	None	-2	3	Mouse	8.1	pKi	=	8.1	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	58438464	3016	28	None	-1	3	Rat	8.5	pKi	=	8.5	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	9060	3016	28	None	-1	3	Rat	8.5	pKi	=	8.5	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	CHEMBL3287218	3016	28	None	-1	3	Rat	8.5	pKi	=	8.5	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	DB14870	3016	28	None	-1	3	Rat	8.5	pKi	=	8.5	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	58438464	3016	28	None	1	3	Human	8.9	pKi	=	8.9	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cells.Measured <i>in vitro</i> in recombinant receptor over-expressing cells.	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	9060	3016	28	None	1	3	Human	8.9	pKi	=	8.9	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cells.Measured <i>in vitro</i> in recombinant receptor over-expressing cells.	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	CHEMBL3287218	3016	28	None	1	3	Human	8.9	pKi	=	8.9	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cells.Measured <i>in vitro</i> in recombinant receptor over-expressing cells.	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	DB14870	3016	28	None	1	3	Human	8.9	pKi	=	8.9	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cells.Measured <i>in vitro</i> in recombinant receptor over-expressing cells.	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	12413	3021	0	None	-3	2	Rat	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	4	1	8	4.3	CC1=CN2C=C(CC(=O)N3CCC4(CN(C4)[C@@H]5CCC6=CC(=CC=C56)C7=CC(C)=NC(O)=N7)CC3)N=C2S1	36631279
	164946906	3021	0	None	-3	2	Rat	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	4	1	8	4.3	CC1=CN2C=C(CC(=O)N3CCC4(CN(C4)[C@@H]5CCC6=CC(=CC=C56)C7=CC(C)=NC(O)=N7)CC3)N=C2S1	36631279
	12413	3021	0	None	3	2	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	4	1	8	4.3	CC1=CN2C=C(CC(=O)N3CCC4(CN(C4)[C@@H]5CCC6=CC(=CC=C56)C7=CC(C)=NC(O)=N7)CC3)N=C2S1	36631279
	164946906	3021	0	None	3	2	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	4	1	8	4.3	CC1=CN2C=C(CC(=O)N3CCC4(CN(C4)[C@@H]5CCC6=CC(=CC=C56)C7=CC(C)=NC(O)=N7)CC3)N=C2S1	36631279
	23631116	4049	19	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	17656463
	3538	4049	19	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	17656463
	CHEMBL243001	4049	19	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	17656463
	1098	1364	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11314756
	1098	1364	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	14763915
	1101	650	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15339248
	10740	1907	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	4	1	3	4.4	COc1ccc(c(c1Cl)Cl)[C@@H](NC(=O)N([C@@H]1CCN(CC1(C)C)C)C)C	25327342
	146170991	1907	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	4	1	3	4.4	COc1ccc(c(c1Cl)Cl)[C@@H](NC(=O)N([C@@H]1CCN(CC1(C)C)C)C)C	25327342
	1092	3109	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	134715446	3109	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	2232	3109	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	6918245	3109	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	CHEMBL106593	3109	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	178024	1940	30	None	-	1	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	5867	1940	30	None	-	1	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	CHEMBL13817	1940	30	None	-	1	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	1099	1757	0	None	-	1	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11314756
	1093	1764	0	None	12	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	4345065	1764	0	None	12	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793

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Ligand source activities (1 row/activity)