Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL3353956 oxyr_human Human No 11.0 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1048 20 11 15 -1.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CS3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353930 oxyr_human Human No 11.0 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1006 20 11 14 -1.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3CC3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353946 oxyr_human Human No 11.0 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1056 20 11 14 -0.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CC(=C3)C)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353948 oxyr_human Human No 11.0 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1060 20 11 15 -0.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=C(C=C3)F)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353932 oxyr_human Human No 11.0 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1006 19 11 14 -1.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C3CCC3)CC(=O)N)CCC(=O)N
CHEMBL3354579 oxyr_human Human No 11.0 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
992 21 12 14 -2.3 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCCO)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353939 oxyr_human Human No 11.0 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1020 19 11 14 -1.0 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C3CCCC3)CC(=O)N)CCC(=O)N
CHEMBL3353956 oxyr_human Human No 11.0 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1048 20 11 15 -1.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CS3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353930 oxyr_human Human No 11.0 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1006 20 11 14 -1.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3CC3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353946 oxyr_human Human No 11.0 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1056 20 11 14 -0.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CC(=C3)C)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353948 oxyr_human Human No 11.0 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1060 20 11 15 -0.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=C(C=C3)F)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353932 oxyr_human Human No 11.0 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1006 19 11 14 -1.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C3CCC3)CC(=O)N)CCC(=O)N
CHEMBL3354579 oxyr_human Human No 11.0 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
992 21 12 14 -2.3 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCCO)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353939 oxyr_human Human No 11.0 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1020 19 11 14 -1.0 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C3CCCC3)CC(=O)N)CCC(=O)N
CHEMBL3353955 oxyr_human Human No 10.7 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1057 21 11 15 -1.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCC3=CC=NC=C3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354571 oxyr_human Human No 10.7 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1062 21 11 15 -0.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCC3=CC=CS3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354592 oxyr_human Human No 10.7 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1038 20 11 13 -0.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CC(=C3)C)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353955 oxyr_human Human No 10.7 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1057 21 11 15 -1.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCC3=CC=NC=C3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354571 oxyr_human Human No 10.7 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1062 21 11 15 -0.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCC3=CC=CS3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354592 oxyr_human Human No 10.7 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1038 20 11 13 -0.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CC(=C3)C)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353942 oxyr_human Human No 10.5 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1010 21 11 15 -2.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCOC)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353942 oxyr_human Human No 10.5 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1010 21 11 15 -2.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCOC)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL395429 oxyr_human Human Yes 10.4 EC50 = 0.0 Funct
Agonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assay
1007 17 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL435716 oxyr_human Human Yes 10.4 EC50 = 0.0 Funct
Agonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assay
992 17 11 14 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL439044 oxyr_human Human Yes 10.4 EC50 = 0.0 Funct
Agonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assay
992 17 11 14 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL395429 oxyr_human Human Yes 10.4 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1007 17 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL435716 oxyr_human Human Yes 10.4 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
992 17 11 14 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL439044 oxyr_human Human Yes 10.4 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
992 17 11 14 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354595 oxyr_human Human No 10.4 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1042 20 11 14 -0.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=C(C=C3)F)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354588 oxyr_human Human No 10.4 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1024 20 11 13 -0.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CC=C3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL395429 oxyr_human Human Yes 10.4 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1007 17 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL435716 oxyr_human Human Yes 10.4 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
992 17 11 14 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL439044 oxyr_human Human Yes 10.4 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
992 17 11 14 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354595 oxyr_human Human No 10.4 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1042 20 11 14 -0.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=C(C=C3)F)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354588 oxyr_human Human No 10.4 EC50 = 0.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1024 20 11 13 -0.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CC=C3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354589 oxyr_human Human No 10.3 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1024 20 11 13 -0.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CC=C3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353929 oxyr_human Human No 10.3 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
992 19 11 14 -1.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C3CC3)CC(=O)N)CCC(=O)N
CHEMBL3354589 oxyr_human Human No 10.3 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1024 20 11 13 -0.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CC=C3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353929 oxyr_human Human No 10.3 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
992 19 11 14 -1.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C3CC3)CC(=O)N)CCC(=O)N
CHEMBL3353931 oxyr_human Human No 10.2 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1008 21 11 14 -1.0 CCCCN(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C(=O)C1CSSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CCC(=O)N)C(C)CC)CC2=CC=C(C=C2)O
CHEMBL3353935 oxyr_human Human No 10.2 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1018 19 11 14 -1.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)N3CC(CC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)O)CC(=O)N)CCC(=O)N
CHEMBL3353949 oxyr_human Human No 10.2 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1072 21 11 15 -0.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=C(C=C3)OC)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353931 oxyr_human Human No 10.2 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1008 21 11 14 -1.0 CCCCN(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C(=O)C1CSSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CCC(=O)N)C(C)CC)CC2=CC=C(C=C2)O
CHEMBL3353935 oxyr_human Human No 10.2 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1018 19 11 14 -1.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)N3CC(CC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)O)CC(=O)N)CCC(=O)N
CHEMBL3353949 oxyr_human Human No 10.2 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1072 21 11 15 -0.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=C(C=C3)OC)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354587 oxyr_human Human No 10.2 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
988 22 10 12 0.2 CCCCCN(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C(=O)C1CCSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CCC(=O)N)C(C)CC)CC2=CC=CC=C2
CHEMBL3354572 oxyr_human Human No 10.2 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1036 20 11 15 -1.9 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3CCCO3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354587 oxyr_human Human No 10.2 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
988 22 10 12 0.2 CCCCCN(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C(=O)C1CCSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CCC(=O)N)C(C)CC)CC2=CC=CC=C2
CHEMBL3354572 oxyr_human Human No 10.2 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1036 20 11 15 -1.9 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3CCCO3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3342789 oxyr_human Human No 10.1 EC50 = 0.1 Funct
Antagonist activity at human OTR expressed in HEK293 cell membranes assessed as inhibition of OT-induced increase in Ca2+ flux preincubated for 5 mins followed by OT addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human OTR expressed in HEK293 cell membranes assessed as inhibition of OT-induced increase in Ca2+ flux preincubated for 5 mins followed by OT addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay
335 4 1 5 2.6 C1=CC=NC(=C1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)Cl
CHEMBL3354591 oxyr_human Human No 10.1 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1038 20 11 13 -0.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CC(=C3)C)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354594 oxyr_human Human Yes 10.1 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1042 20 11 14 -0.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=C(C=C3)F)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354591 oxyr_human Human No 10.1 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1038 20 11 13 -0.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CC(=C3)C)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354594 oxyr_human Human Yes 10.1 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1042 20 11 14 -0.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=C(C=C3)F)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354584 oxyr_human Human No 10.1 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
974 21 10 12 -0.4 CCCCN(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C(=O)C1CCSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CCC(=O)N)C(C)CC)CC2=CC=CC=C2
CHEMBL3354600 oxyr_human Human No 10.1 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1030 20 11 14 -0.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CS3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354584 oxyr_human Human No 10.1 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
974 21 10 12 -0.4 CCCCN(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C(=O)C1CCSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CCC(=O)N)C(C)CC)CC2=CC=CC=C2
CHEMBL3354600 oxyr_human Human No 10.1 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1030 20 11 14 -0.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CS3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL435716 oxyr_human Human Yes 10.0 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
992 17 11 14 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL439044 oxyr_human Human Yes 10.0 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
992 17 11 14 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3342790 oxyr_human Human No 10.0 EC50 = 0.1 Funct
Antagonist activity at human OTR expressed in HEK293 cell membranes assessed as inhibition of OT-induced increase in Ca2+ flux preincubated for 5 mins followed by OT addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human OTR expressed in HEK293 cell membranes assessed as inhibition of OT-induced increase in Ca2+ flux preincubated for 5 mins followed by OT addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay
368 4 1 8 2.9 C1=CC=NC(=C1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)C(F)(F)F
CHEMBL435716 oxyr_human Human Yes 10.0 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
992 17 11 14 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL439044 oxyr_human Human Yes 10.0 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
992 17 11 14 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353944 oxyr_human Human No 10.0 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1042 20 11 14 -0.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CC=C3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354585 oxyr_human Human No 10.0 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1004 22 11 13 -0.2 CCCCCN(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C(=O)C1CSCCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CCC(=O)N)C(C)CC)CC2=CC=C(C=C2)O
CHEMBL3354575 oxyr_human Human No 10.0 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
992 21 11 14 -2.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCOC)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354570 oxyr_human Human No 10.0 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1032 20 11 15 -1.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CO3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353944 oxyr_human Human No 10.0 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1042 20 11 14 -0.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CC=C3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354585 oxyr_human Human No 10.0 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1004 22 11 13 -0.2 CCCCCN(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C(=O)C1CSCCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CCC(=O)N)C(C)CC)CC2=CC=C(C=C2)O
CHEMBL3354575 oxyr_human Human No 10.0 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
992 21 11 14 -2.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCOC)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354570 oxyr_human Human No 10.0 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1032 20 11 15 -1.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CO3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354581 oxyr_human Human No 9.9 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
990 21 11 13 -0.7 CCCCN(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C(=O)C1CSCCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CCC(=O)N)C(C)CC)CC2=CC=C(C=C2)O
CHEMBL3353953 oxyr_human Human No 9.9 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1056 21 11 14 -0.3 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCC3=CC=CC=C3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353945 oxyr_human Human No 9.9 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1056 20 11 14 -0.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CC=C3C)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353954 oxyr_human Human No 9.9 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1057 21 11 15 -1.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCC3=CC=CC=N3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354581 oxyr_human Human No 9.9 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
990 21 11 13 -0.7 CCCCN(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C(=O)C1CSCCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CCC(=O)N)C(C)CC)CC2=CC=C(C=C2)O
CHEMBL3353953 oxyr_human Human No 9.9 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1056 21 11 14 -0.3 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCC3=CC=CC=C3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353945 oxyr_human Human No 9.9 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1056 20 11 14 -0.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CC=C3C)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353954 oxyr_human Human No 9.9 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1057 21 11 15 -1.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCC3=CC=CC=N3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353938 oxyr_human Human No 9.9 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1022 22 11 14 -0.5 CCCCCN(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C(=O)C1CSSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CCC(=O)N)C(C)CC)CC2=CC=C(C=C2)O
CHEMBL3354580 oxyr_human Human No 9.9 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
992 21 12 14 -2.3 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCCO)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353938 oxyr_human Human No 9.9 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1022 22 11 14 -0.5 CCCCCN(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C(=O)C1CSSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CCC(=O)N)C(C)CC)CC2=CC=C(C=C2)O
CHEMBL3354580 oxyr_human Human No 9.9 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
992 21 12 14 -2.3 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCCO)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354582 oxyr_human Human No 9.9 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
990 21 11 13 -0.7 CCCCN(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C(=O)C1CCSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CCC(=O)N)C(C)CC)CC2=CC=C(C=C2)O
CHEMBL3354601 oxyr_human Human No 9.9 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1030 20 11 14 -0.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CS3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354582 oxyr_human Human No 9.9 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
990 21 11 13 -0.7 CCCCN(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C(=O)C1CCSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CCC(=O)N)C(C)CC)CC2=CC=C(C=C2)O
CHEMBL3354601 oxyr_human Human No 9.9 EC50 = 0.1 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1030 20 11 14 -0.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CS3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353947 oxyr_human Human No 9.8 EC50 = 0.2 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1056 20 11 14 -0.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=C(C=C3)C)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353947 oxyr_human Human No 9.8 EC50 = 0.2 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1056 20 11 14 -0.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=C(C=C3)C)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354576 oxyr_human Human No 9.8 EC50 = 0.2 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
992 21 11 14 -2.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCOC)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354576 oxyr_human Human No 9.8 EC50 = 0.2 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
992 21 11 14 -2.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCOC)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353936 oxyr_human Human No 9.7 EC50 = 0.2 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1032 20 10 14 -1.2 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)N3CC(CC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)OC)CC(=O)N)CCC(=O)N
CHEMBL3353936 oxyr_human Human No 9.7 EC50 = 0.2 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1032 20 10 14 -1.2 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)N3CC(CC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)OC)CC(=O)N)CCC(=O)N
CHEMBL3354583 oxyr_human Human No 9.6 EC50 = 0.2 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
974 21 10 12 -0.4 CCCCN(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C(=O)C1CSCCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CCC(=O)N)C(C)CC)CC2=CC=CC=C2
CHEMBL3354583 oxyr_human Human No 9.6 EC50 = 0.2 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
974 21 10 12 -0.4 CCCCN(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C(=O)C1CSCCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CCC(=O)N)C(C)CC)CC2=CC=CC=C2
CHEMBL3354586 oxyr_human Human No 9.6 EC50 = 0.3 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1004 22 11 13 -0.2 CCCCCN(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C(=O)C1CCSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CCC(=O)N)C(C)CC)CC2=CC=C(C=C2)O
CHEMBL3354586 oxyr_human Human No 9.6 EC50 = 0.3 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1004 22 11 13 -0.2 CCCCCN(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C(=O)C1CCSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CCC(=O)N)C(C)CC)CC2=CC=C(C=C2)O
CHEMBL3813771 oxyr_human Human No 9.5 EC50 = 0.3 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1006 17 10 14 -1.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)N(C(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)C)CC(=O)N)CCC(=O)N
CHEMBL3813771 oxyr_human Human No 9.5 EC50 = 0.3 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1006 17 10 14 -1.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)N(C(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)C)CC(=O)N)CCC(=O)N
CHEMBL395429 oxyr_human Human Yes 9.5 EC50 = 0.3 Funct
Agonist activity at human mammary gland oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human mammary gland oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assay
1007 17 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354602 oxyr_human Human No 9.5 EC50 = 0.3 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1014 20 10 13 -0.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=CC=C2)C(=O)N(CC3=CC=CS3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354602 oxyr_human Human No 9.5 EC50 = 0.3 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1014 20 10 13 -0.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=CC=C2)C(=O)N(CC3=CC=CS3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353937 oxyr_human Human No 9.4 EC50 = 0.4 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
948 19 11 13 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353937 oxyr_human Human No 9.4 EC50 = 0.4 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
948 19 11 13 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353943 oxyr_human Human No 9.4 EC50 = 0.4 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1010 21 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCCO)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353943 oxyr_human Human No 9.4 EC50 = 0.4 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1010 21 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCCO)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354590 oxyr_human Human No 9.4 EC50 = 0.4 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1008 20 10 12 -0.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=CC=C2)C(=O)N(CC3=CC=CC=C3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354590 oxyr_human Human No 9.4 EC50 = 0.4 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1008 20 10 12 -0.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=CC=C2)C(=O)N(CC3=CC=CC=C3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353952 oxyr_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1043 20 11 15 -1.9 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=NC=C3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353952 oxyr_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1043 20 11 15 -1.9 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=NC=C3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3814633 oxyr_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1021 17 11 15 -2.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)N(C)CC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3814633 oxyr_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1021 17 11 15 -2.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)N(C)CC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3814744 oxyr_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1021 17 11 15 -2.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)N(C)C(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3814744 oxyr_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1021 17 11 15 -2.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)N(C)C(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354593 oxyr_human Human No 9.3 EC50 = 0.6 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1022 20 10 12 0.2 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=CC=C2)C(=O)N(CC3=CC=CC(=C3)C)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354593 oxyr_human Human No 9.3 EC50 = 0.6 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1022 20 10 12 0.2 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=CC=C2)C(=O)N(CC3=CC=CC(=C3)C)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3815099 oxyr_human Human No 9.2 EC50 = 0.6 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1020 17 9 14 -1.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)N(C)C(CC(C)C)C(=O)N(C)CC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3815099 oxyr_human Human No 9.2 EC50 = 0.6 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1020 17 9 14 -1.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)N(C)C(CC(C)C)C(=O)N(C)CC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL395429 oxyr_human Human Yes 9.2 EC50 = 0.7 Funct
Agonist activity at human OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayAgonist activity at human OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
1007 17 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3301668 oxyr_human Human Yes 9.2 EC50 = 0.7 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
988 18 10 13 -1.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OC)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3301668 oxyr_human Human Yes 9.2 EC50 = 0.7 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
988 18 10 13 -1.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OC)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354599 oxyr_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1022 21 10 12 0.3 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=CC=C2)C(=O)N(CCC3=CC=CC=C3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354599 oxyr_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1022 21 10 12 0.3 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=CC=C2)C(=O)N(CCC3=CC=CC=C3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353934 oxyr_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1034 19 10 14 -0.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OC)C(=O)N3CC(CC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)SC)CC(=O)N)CCC(=O)N
CHEMBL3353934 oxyr_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1034 19 10 14 -0.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OC)C(=O)N3CC(CC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)SC)CC(=O)N)CCC(=O)N
CHEMBL3354578 oxyr_human Human No 9.1 EC50 = 0.9 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
976 21 10 13 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=CC=C2)C(=O)N(CCOC)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354578 oxyr_human Human No 9.1 EC50 = 0.9 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
976 21 10 13 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=CC=C2)C(=O)N(CCOC)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3352839 oxyr_human Human No 9.1 EC50 = 0.9 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
976 21 11 13 -1.9 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=CC=C2)C(=O)N(CCCO)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3352839 oxyr_human Human No 9.1 EC50 = 0.9 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
976 21 11 13 -1.9 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CCSCCC(=O)NC(C(=O)N1)CC2=CC=CC=C2)C(=O)N(CCCO)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354577 oxyr_human Human No 9.0 EC50 = 1.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
976 21 10 13 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=CC=C2)C(=O)N(CCOC)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354577 oxyr_human Human No 9.0 EC50 = 1.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
976 21 10 13 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=CC=C2)C(=O)N(CCOC)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353933 oxyr_human Human No 9.0 EC50 = 1.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1018 19 10 14 -1.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OC)C(=O)N3CC(CC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)OC)CC(=O)N)CCC(=O)N
CHEMBL3353933 oxyr_human Human No 9.0 EC50 = 1.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1018 19 10 14 -1.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OC)C(=O)N3CC(CC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)OC)CC(=O)N)CCC(=O)N
CHEMBL3813894 oxyr_human Human No 9.0 EC50 = 1.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1021 17 11 15 -2.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)N(C(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)C)CC(=O)N)CCC(=O)N
CHEMBL3813894 oxyr_human Human No 9.0 EC50 = 1.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1021 17 11 15 -2.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)N(C(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)C)CC(=O)N)CCC(=O)N
CHEMBL3353951 oxyr_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1043 20 11 15 -1.9 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CN=CC=C3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353941 oxyr_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1034 19 11 14 -0.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C3CCCCC3)CC(=O)N)CCC(=O)N
CHEMBL3353950 oxyr_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1043 20 11 15 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CC=N3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353951 oxyr_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1043 20 11 15 -1.9 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CN=CC=C3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3353941 oxyr_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1034 19 11 14 -0.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)C3CCCCC3)CC(=O)N)CCC(=O)N
CHEMBL3353950 oxyr_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1043 20 11 15 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CC3=CC=CC=N3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3301668 oxyr_human Human Yes 8.0 EC50 = 10 Funct
Agonist activity at human OTR receptor expressed in HEK293FT cells incubated for 30 mins by beta-arrestin recruitment assayAgonist activity at human OTR receptor expressed in HEK293FT cells incubated for 30 mins by beta-arrestin recruitment assay
988 18 10 13 -1.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OC)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354574 oxyr_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1065 21 11 16 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCN3CCOCC3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3354574 oxyr_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1065 21 11 16 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCN3CCOCC3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3814120 oxyr_human Human No 8.0 EC50 = 10.8 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1035 17 10 15 -2.2 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)N(C(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)N(C)CC(=O)N)C)CC(=O)N)CCC(=O)N
CHEMBL3814120 oxyr_human Human No 8.0 EC50 = 10.8 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1035 17 10 15 -2.2 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)N(C(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)N(C)CC(=O)N)C)CC(=O)N)CCC(=O)N
CHEMBL395429 oxyr_human Human Yes 8.0 EC50 = 10.8 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assayAgonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay
1007 17 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL395429 oxyr_human Human Yes 8.0 EC50 = 10.8 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assayAgonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay
1007 17 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1819550 oxyr_human Human No 7.0 EC50 = 104.7 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
968 17 12 16 -5.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CO2)N)C(=O)N3CCCC3C(=O)NC(CCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1817752 oxyr_human Human No 7.0 EC50 = 104.7 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1020 19 12 15 -3.2 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CC(=O)N
CHEMBL1819550 oxyr_human Human No 7.0 EC50 = 105 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
968 17 12 16 -5.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CO2)N)C(=O)N3CCCC3C(=O)NC(CCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1819550 oxyr_human Human No 7.0 EC50 = 105 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
968 17 12 16 -5.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CO2)N)C(=O)N3CCCC3C(=O)NC(CCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1817761 oxyr_human Human No 7.0 EC50 = 109.7 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1040 20 12 16 -3.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CS2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1817761 oxyr_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1040 20 12 16 -3.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CS2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1817752 oxyr_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1020 19 12 15 -3.2 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CC(=O)N
CHEMBL1817761 oxyr_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1040 20 12 16 -3.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CS2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1817752 oxyr_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1020 19 12 15 -3.2 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CC(=O)N
CHEMBL1817709 oxyr_human Human Yes 6.0 EC50 = 1100 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1048 21 12 15 -2.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCCC(=O)N
CHEMBL1817709 oxyr_human Human Yes 6.0 EC50 = 1100 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1048 21 12 15 -2.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCCC(=O)N
CHEMBL276711 oxyr_human Human Yes 4.9 EC50 = 11468 Funct
PUBCHEM_BIOASSAY: Counterscreen for vasopressin 1 receptor (V1R) agonists: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for vasopressin 1 receptor (V1R) agonists: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
238 1 2 1 2.5 CC1=CC(=C(N1)C=C2C3=CC=CC=C3NC2=O)C
CHEMBL276711 oxyr_human Human Yes 4.9 EC50 = 11468 Funct
PUBCHEM_BIOASSAY: Counterscreen for vasopressin 1 receptor (V1R) agonists: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for vasopressin 1 receptor (V1R) agonists: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
238 1 2 1 2.5 CC1=CC(=C(N1)C=C2C3=CC=CC=C3NC2=O)C
CHEMBL1819547 oxyr_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
985 17 12 17 -5.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CSC=N2)N)C(=O)N3CCCC3C(=O)NC(CCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1819547 oxyr_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
985 17 12 17 -5.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CSC=N2)N)C(=O)N3CCCC3C(=O)NC(CCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1819547 oxyr_human Human No 5.9 EC50 = 1230.3 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
985 17 12 17 -5.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CSC=N2)N)C(=O)N3CCCC3C(=O)NC(CCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL363910 oxyr_human Human Yes 6.9 EC50 = 125 Funct
Activity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assayActivity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
403 2 0 2 3.9 CC1=NN(C=C1)C2=CC(=C(C=C2)C(=O)N3CC4=CC=CN4CC5=CC=CC=C53)Cl
CHEMBL363910 oxyr_human Human Yes 6.9 EC50 = 125 Funct
Activity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assayActivity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
403 2 0 2 3.9 CC1=NN(C=C1)C2=CC(=C(C=C2)C(=O)N3CC4=CC=CN4CC5=CC=CC=C53)Cl
CHEMBL3814126 oxyr_human Human No 7.8 EC50 = 14.7 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1021 17 11 15 -2.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1C)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3814126 oxyr_human Human No 7.8 EC50 = 14.7 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1021 17 11 15 -2.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1C)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL395429 oxyr_human Human Yes 7.8 EC50 = 15 Funct
Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assayActivity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay
1007 17 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL373742 oxyr_human Human Yes 7.8 EC50 = 15 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1084 19 14 16 -4.8 C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N
CHEMBL395429 oxyr_human Human Yes 7.8 EC50 = 15 Funct
Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assayActivity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay
1007 17 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL373742 oxyr_human Human Yes 7.8 EC50 = 15 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1084 19 14 16 -4.8 C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N
CHEMBL373742 oxyr_human Human Yes 7.8 EC50 = 15.1 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1084 19 14 16 -4.8 C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N
CHEMBL1817705 oxyr_human Human No 7.8 EC50 = 15.5 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1006 19 12 15 -3.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCCNC)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3813858 oxyr_human Human No 7.8 EC50 = 15.6 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1035 17 10 15 -2.2 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)N(C(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)N(C)C(CC(C)C)C(=O)NCC(=O)N)C)CC(=O)N)CCC(=O)N
CHEMBL3813858 oxyr_human Human No 7.8 EC50 = 15.6 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1035 17 10 15 -2.2 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)N(C(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)N(C)C(CC(C)C)C(=O)NCC(=O)N)C)CC(=O)N)CCC(=O)N
CHEMBL3763342 oxyr_human Human Yes 6.8 EC50 = 150 Funct
Agonist activity at human OTR receptor expressed in HEK293FT cells incubated for 30 mins by beta-arrestin recruitment assayAgonist activity at human OTR receptor expressed in HEK293FT cells incubated for 30 mins by beta-arrestin recruitment assay
582 5 4 7 2.2 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCN(CC5)CC6=CC(=CC(=C6)O)O
CHEMBL445393 oxyr_human Human No 5.8 EC50 = 1500 Funct
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
596 8 2 6 3.5 COC1CC(N(C1)C(=O)NCC2=C(C=C(C=C2)C(=O)N3CCCCC4=C3C=CS4)Cl)C(=O)NCCC5=CC=CC=N5
CHEMBL445393 oxyr_human Human No 5.8 EC50 = 1500 Funct
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
596 8 2 6 3.5 COC1CC(N(C1)C(=O)NCC2=C(C=C(C=C2)C(=O)N3CCCCC4=C3C=CS4)Cl)C(=O)NCCC5=CC=CC=N5
CHEMBL3342796 oxyr_human Human No 5.8 EC50 = 1570 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
437 4 1 12 3.1 C1=CC(=CC=C1C(F)(F)F)S(=O)(=O)NC2=CC=NN2C3=NC=C(C=N3)C(F)(F)F
CHEMBL3342798 oxyr_human Human No 5.8 EC50 = 1570 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
375 6 1 7 3.3 CCC1=CC=C(C=C1)S(=O)(=O)NC2=CC=NN2C3=NC(=NS3)C4CC4
CHEMBL3342796 oxyr_human Human No 5.8 EC50 = 1570 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
437 4 1 12 3.1 C1=CC(=CC=C1C(F)(F)F)S(=O)(=O)NC2=CC=NN2C3=NC=C(C=N3)C(F)(F)F
CHEMBL3342798 oxyr_human Human No 5.8 EC50 = 1570 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
375 6 1 7 3.3 CCC1=CC=C(C=C1)S(=O)(=O)NC2=CC=NN2C3=NC(=NS3)C4CC4
CHEMBL1817705 oxyr_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1006 19 12 15 -3.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCCNC)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1817705 oxyr_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1006 19 12 15 -3.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCCNC)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL473106 oxyr_human Human Yes 4.8 EC50 = 16681 Funct
PUBCHEM_BIOASSAY: Counterscreen for vasopressin 1 receptor (V1R) agonists: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for vasopressin 1 receptor (V1R) agonists: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
346 3 0 5 3.4 CCN1C(=C2C=C(N(C(=C2)C)CC3=CC=CO3)C)C(=O)SC1=S
CHEMBL473106 oxyr_human Human Yes 4.8 EC50 = 16681 Funct
PUBCHEM_BIOASSAY: Counterscreen for vasopressin 1 receptor (V1R) agonists: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for vasopressin 1 receptor (V1R) agonists: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
346 3 0 5 3.4 CCN1C(=C2C=C(N(C(=C2)C)CC3=CC=CO3)C)C(=O)SC1=S
CHEMBL3342794 oxyr_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
382 4 1 8 3.3 CC1=CC(=NC=C1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)C(F)(F)F
CHEMBL3342794 oxyr_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
382 4 1 8 3.3 CC1=CC(=NC=C1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)C(F)(F)F
CHEMBL1819557 oxyr_human Human No 6.8 EC50 = 173.8 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1006 18 12 15 -3.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)NC
CHEMBL1819557 oxyr_human Human No 6.8 EC50 = 173.8 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1006 18 12 15 -3.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)NC
CHEMBL3814232 oxyr_human Human No 6.8 EC50 = 174.9 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1035 18 11 15 -1.9 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)N(C(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)NC)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)C)CC(=O)N)CCC(=O)N
CHEMBL3814232 oxyr_human Human No 6.8 EC50 = 174.9 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1035 18 11 15 -1.9 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)N(C(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)NC)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)C)CC(=O)N)CCC(=O)N
CHEMBL1819556 oxyr_human Human No 6.8 EC50 = 180 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
928 15 12 15 -5.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC2(CCC2)C(=O)N1)N)C(=O)N3CCCC3C(=O)NC(CCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1819556 oxyr_human Human No 6.8 EC50 = 180 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
928 15 12 15 -5.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC2(CCC2)C(=O)N1)N)C(=O)N3CCCC3C(=O)NC(CCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1390471 oxyr_human Human Yes 4.7 EC50 = 18834 Funct
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]
405 9 2 4 4.1 COC1=C(C=C(C=C1)CCNCC(CN2C3=CC=CC=C3C4=CC=CC=C42)O)OC
CHEMBL1390471 oxyr_human Human Yes 4.7 EC50 = 18834 Funct
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]
405 9 2 4 4.1 COC1=C(C=C(C=C1)CCNCC(CN2C3=CC=CC=C3C4=CC=CC=C42)O)OC
CHEMBL3342789 oxyr_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human OTR expressed in HEK293 cell membranes induction of IP1 accumulation at 0.1 to 10 uM measured after 1 hr by fluorescence assayAgonist activity at human OTR expressed in HEK293 cell membranes induction of IP1 accumulation at 0.1 to 10 uM measured after 1 hr by fluorescence assay
335 4 1 5 2.6 C1=CC=NC(=C1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)Cl
CHEMBL3342789 oxyr_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
335 4 1 5 2.6 C1=CC=NC(=C1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)Cl
CHEMBL3342793 oxyr_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
353 4 1 6 2.7 C1=CC=NC(=C1)N2C(=CC=N2)NS(=O)(=O)C3=C(C=C(C=C3)Cl)F
CHEMBL3354573 oxyr_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1049 21 12 15 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCC3CCCN3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3342789 oxyr_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
335 4 1 5 2.6 C1=CC=NC(=C1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)Cl
CHEMBL3342793 oxyr_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
353 4 1 6 2.7 C1=CC=NC(=C1)N2C(=CC=N2)NS(=O)(=O)C3=C(C=C(C=C3)Cl)F
CHEMBL3354573 oxyr_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1049 21 12 15 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N(CCC3CCCN3)CC(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL395429 oxyr_mouse Mouse Yes 8.7 EC50 = 2 Funct
Agonist activity at mouse OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayAgonist activity at mouse OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
1007 17 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL395429 oxyr_human Human Yes 8.6 EC50 = 2.3 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1007 17 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL395429 oxyr_human Human Yes 8.6 EC50 = 2.3 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1007 17 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1817709 oxyr_human Human Yes 8.6 EC50 = 2.4 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1048 21 12 15 -2.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCCC(=O)N
CHEMBL3813707 oxyr_human Human No 8.6 EC50 = 2.4 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1020 17 9 14 -1.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)N(C(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)N(C)CC(=O)N)C)CC(=O)N)CCC(=O)N
CHEMBL3813707 oxyr_human Human No 8.6 EC50 = 2.4 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1020 17 9 14 -1.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)N(C(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)N(C)CC(=O)N)C)CC(=O)N)CCC(=O)N
CHEMBL3189462 oxyr_human Human Yes 4.7 EC50 = 21762 Funct
PUBCHEM_BIOASSAY: Counterscreen for vasopressin 1 receptor (V1R) agonists: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for vasopressin 1 receptor (V1R) agonists: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
379 6 2 6 2.2 CCN(CC)C1=CC2=C(C=C1)C=C(C(=NNC(=O)C3=CC=NC=C3)O2)C(=O)N
CHEMBL3189462 oxyr_human Human Yes 4.7 EC50 = 21762 Funct
PUBCHEM_BIOASSAY: Counterscreen for vasopressin 1 receptor (V1R) agonists: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for vasopressin 1 receptor (V1R) agonists: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
379 6 2 6 2.2 CCN(CC)C1=CC2=C(C=C1)C=C(C(=NNC(=O)C3=CC=NC=C3)O2)C(=O)N
CHEMBL373742 oxyr_human Human Yes 7.7 EC50 = 22 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1084 19 14 16 -4.8 C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N
CHEMBL373742 oxyr_human Human Yes 7.7 EC50 = 22 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1084 19 14 16 -4.8 C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N
CHEMBL443300 oxyr_human Human No 5.7 EC50 = 2200 Funct
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
642 6 1 6 4.2 COC1CC(N(C1)C(=O)NCC2=C(C=C(C=C2)C(=O)N3CCCCC4=C3C=CS4)Cl)C(=O)N5CCC(CC5)N6CCCCC6
CHEMBL443300 oxyr_human Human No 5.7 EC50 = 2200 Funct
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
642 6 1 6 4.2 COC1CC(N(C1)C(=O)NCC2=C(C=C(C=C2)C(=O)N3CCCCC4=C3C=CS4)Cl)C(=O)N5CCC(CC5)N6CCCCC6
CHEMBL3814165 oxyr_human Human No 7.6 EC50 = 23.9 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1021 17 11 15 -2.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)N(C(C(=O)N1)CC2=CC=C(C=C2)O)C)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3814165 oxyr_human Human No 7.6 EC50 = 23.9 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1021 17 11 15 -2.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)N(C(C(=O)N1)CC2=CC=C(C=C2)O)C)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL362382 oxyr_human Human No 5.6 EC50 = 2300 Funct
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
628 6 1 6 3.8 COC1CC(N(C1)C(=O)NCC2=C(C=C(C=C2)C(=O)N3CCCCC4=C3C=CS4)Cl)C(=O)N5CCC(CC5)N6CCCC6
CHEMBL362382 oxyr_human Human No 5.6 EC50 = 2300 Funct
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
628 6 1 6 3.8 COC1CC(N(C1)C(=O)NCC2=C(C=C(C=C2)C(=O)N3CCCCC4=C3C=CS4)Cl)C(=O)N5CCC(CC5)N6CCCC6
CHEMBL3763342 oxyr_human Human Yes 7.6 EC50 = 24 Funct
Agonist activity at human OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayAgonist activity at human OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
582 5 4 7 2.2 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCN(CC5)CC6=CC(=CC(=C6)O)O
CHEMBL3342791 oxyr_human Human No 5.6 EC50 = 2460 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
352 4 1 5 2.9 C1=CC(=CC=C1N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)Cl)F
CHEMBL3342791 oxyr_human Human No 5.6 EC50 = 2460 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
352 4 1 5 2.9 C1=CC(=CC=C1N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)Cl)F
CHEMBL3814617 oxyr_human Human No 7.6 EC50 = 26.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1021 17 11 15 -2.4 CCC(C)C1C(=O)NC(C(=O)N(C(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)C)CCC(=O)N
CHEMBL3814617 oxyr_human Human No 7.6 EC50 = 26.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1021 17 11 15 -2.4 CCC(C)C1C(=O)NC(C(=O)N(C(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)C)CCC(=O)N
CHEMBL1817756 oxyr_human Human No 6.6 EC50 = 257.0 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1024 20 12 16 -3.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CO2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL395429 oxyr_human Human Yes 7.6 EC50 = 26 Funct
Agonist activity at human OTR receptor expressed in HEK293FT cells incubated for 30 mins by beta-arrestin recruitment assayAgonist activity at human OTR receptor expressed in HEK293FT cells incubated for 30 mins by beta-arrestin recruitment assay
1007 17 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1817756 oxyr_human Human No 6.6 EC50 = 260 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1024 20 12 16 -3.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CO2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1817756 oxyr_human Human No 6.6 EC50 = 260 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1024 20 12 16 -3.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CO2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1559201 oxyr_human Human Yes 5.6 EC50 = 2671 Funct
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]
473 1 3 4 6.9 CC1(CCC2(C(C1)C3=CCC4C5(CCC(C(C5CCC4(C3(CC2O)C)C)(C)C)O)C)C(=O)O)C
CHEMBL1559201 oxyr_human Human Yes 5.6 EC50 = 2671 Funct
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]
473 1 3 4 6.9 CC1(CCC2(C(C1)C3=CCC4C5(CCC(C(C5CCC4(C3(CC2O)C)C)(C)C)O)C)C(=O)O)C
CHEMBL1495292 oxyr_human Human Yes 4.6 EC50 = 27366 Funct
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]
304 4 2 4 3.5 COC1=CC=C(C=C1)CNC2=NC=NC3=C2NC4=CC=CC=C43
CHEMBL1495292 oxyr_human Human Yes 4.6 EC50 = 27366 Funct
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]
304 4 2 4 3.5 COC1=CC=C(C=C1)CNC2=NC=NC3=C2NC4=CC=CC=C43
CHEMBL360648 oxyr_human Human Yes 7.6 EC50 = 28 Funct
Agonist activity at human OTR expressed in HEK cells assessed as increase in intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assayAgonist activity at human OTR expressed in HEK cells assessed as increase in intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay
601 4 2 6 2.5 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCCC5C(=S)N6CCCN(CC6)C
CHEMBL364994 oxyr_human Human No 5.6 EC50 = 2800 Funct
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
588 5 1 6 2.9 CN1CCCN(CC1)C(=O)C2CC(CN2C(=O)NCC3=C(C=C(C=C3)C(=O)N4CCCCC5=C4C=CS5)Cl)OC
CHEMBL364994 oxyr_human Human No 5.6 EC50 = 2800 Funct
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
588 5 1 6 2.9 CN1CCCN(CC1)C(=O)C2CC(CN2C(=O)NCC3=C(C=C(C=C3)C(=O)N4CCCCC5=C4C=CS5)Cl)OC
CHEMBL3813879 oxyr_human Human No 6.6 EC50 = 283.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1035 17 10 15 -2.2 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)N(C(CSSCC(C(=O)NC(C(=O)N1C)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)C)CC(=O)N)CCC(=O)N
CHEMBL3813879 oxyr_human Human No 6.6 EC50 = 283.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1035 17 10 15 -2.2 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)N(C(CSSCC(C(=O)NC(C(=O)N1C)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)C)CC(=O)N)CCC(=O)N
CHEMBL1819548 oxyr_human Human No 7.5 EC50 = 29 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
984 17 12 16 -4.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CS2)N)C(=O)N3CCCC3C(=O)NC(CCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3763342 oxyr_mouse Mouse Yes 7.5 EC50 = 29 Funct
Agonist activity at recombinant mouse OTR expressed in CHO-K1 cells assessed as induction of Ca2+ mobilization after overnight incubation by FLIPR assayAgonist activity at recombinant mouse OTR expressed in CHO-K1 cells assessed as induction of Ca2+ mobilization after overnight incubation by FLIPR assay
582 5 4 7 2.2 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCN(CC5)CC6=CC(=CC(=C6)O)O
CHEMBL1819548 oxyr_human Human No 7.5 EC50 = 29 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
984 17 12 16 -4.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CS2)N)C(=O)N3CCCC3C(=O)NC(CCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1819549 oxyr_human Human No 7.5 EC50 = 29.5 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
984 17 12 16 -4.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CSC=C2)N)C(=O)N3CCCC3C(=O)NC(CCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1819548 oxyr_human Human No 7.5 EC50 = 29.5 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
984 17 12 16 -4.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CS2)N)C(=O)N3CCCC3C(=O)NC(CCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3763342 oxyr_human Human Yes 8.5 EC50 = 3 Funct
Agonist activity at human OTR expressed in HEK cells assessed as increase in intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assayAgonist activity at human OTR expressed in HEK cells assessed as increase in intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay
582 5 4 7 2.2 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCN(CC5)CC6=CC(=CC(=C6)O)O
CHEMBL395429 oxyr_human Human Yes 8.5 EC50 = 3 Funct
Agonist activity at recombinant human oxytocin receptor expressed in CHO-DUKX-A2 cells assessed as change in intracellular calcium level by FLIPR assayAgonist activity at recombinant human oxytocin receptor expressed in CHO-DUKX-A2 cells assessed as change in intracellular calcium level by FLIPR assay
1007 17 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL395429 oxyr_human Human Yes 8.5 EC50 = 3 Funct
Agonist activity at recombinant human oxytocin receptor expressed in CHO-DUKX-A2 cells assessed as change in intracellular calcium level by FLIPR assayAgonist activity at recombinant human oxytocin receptor expressed in CHO-DUKX-A2 cells assessed as change in intracellular calcium level by FLIPR assay
1007 17 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1819541 oxyr_human Human No 8.5 EC50 = 3.3 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1008 18 13 16 -4.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CCCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1819541 oxyr_human Human No 8.5 EC50 = 3.3 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1008 18 13 16 -4.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CCCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1819541 oxyr_human Human No 8.5 EC50 = 3.3 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1008 18 13 16 -4.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CCCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1819549 oxyr_human Human No 7.5 EC50 = 30 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
984 17 12 16 -4.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CSC=C2)N)C(=O)N3CCCC3C(=O)NC(CCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1819549 oxyr_human Human No 7.5 EC50 = 30 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
984 17 12 16 -4.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CSC=C2)N)C(=O)N3CCCC3C(=O)NC(CCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1817707 oxyr_human Human No 7.5 EC50 = 31.6 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1020 20 12 15 -3.3 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCCNCC)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL2369425 oxyr_human Human No 7.5 EC50 = 32 Funct
Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assayActivity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay
990 17 12 15 -3.9 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)O)CC(=O)N)CCC(=O)N
CHEMBL1817706 oxyr_human Human No 7.5 EC50 = 32 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1034 21 12 15 -2.7 CCCNCCCC(C(=O)NCC(=O)N)NC(=O)C1CCCN1C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)C(C)CC)CC3=CC=CC=C3)N
CHEMBL1817707 oxyr_human Human No 7.5 EC50 = 32 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1020 20 12 15 -3.3 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCCNCC)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL2369425 oxyr_human Human No 7.5 EC50 = 32 Funct
Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assayActivity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay
990 17 12 15 -3.9 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)O)CC(=O)N)CCC(=O)N
CHEMBL1817706 oxyr_human Human No 7.5 EC50 = 32 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1034 21 12 15 -2.7 CCCNCCCC(C(=O)NCC(=O)N)NC(=O)C1CCCN1C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)C(C)CC)CC3=CC=CC=C3)N
CHEMBL1817707 oxyr_human Human No 7.5 EC50 = 32 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1020 20 12 15 -3.3 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCCNCC)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1817706 oxyr_human Human No 7.5 EC50 = 32.4 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1034 21 12 15 -2.7 CCCNCCCC(C(=O)NCC(=O)N)NC(=O)C1CCCN1C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)C(C)CC)CC3=CC=CC=C3)N
CHEMBL360648 oxyr_human Human Yes 7.5 EC50 = 33 Funct
Activity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assayActivity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
601 4 2 6 2.5 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCCC5C(=S)N6CCCN(CC6)C
CHEMBL1817704 oxyr_human Human No 7.5 EC50 = 33 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1034 20 12 15 -2.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL360648 oxyr_human Human Yes 7.5 EC50 = 33 Funct
Agonist activity at human OTR receptor expressed in CHO cells co-expressing NFAT-luciferase incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human OTR receptor expressed in CHO cells co-expressing NFAT-luciferase incubated for 5 hrs by luciferase reporter gene assay
601 4 2 6 2.5 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCCC5C(=S)N6CCCN(CC6)C
CHEMBL360648 oxyr_human Human Yes 7.5 EC50 = 33 Funct
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
601 4 2 6 2.5 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCCC5C(=S)N6CCCN(CC6)C
CHEMBL360648 oxyr_human Human Yes 7.5 EC50 = 33 Funct
Activity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assayActivity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
601 4 2 6 2.5 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCCC5C(=S)N6CCCN(CC6)C
CHEMBL1817704 oxyr_human Human No 7.5 EC50 = 33 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1034 20 12 15 -2.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL360648 oxyr_human Human Yes 7.5 EC50 = 33 Funct
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
601 4 2 6 2.5 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCCC5C(=S)N6CCCN(CC6)C
CHEMBL1817704 oxyr_human Human No 7.5 EC50 = 33.1 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1034 20 12 15 -2.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3813883 oxyr_human Human No 8.4 EC50 = 4.2 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1020 17 9 14 -1.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)N(C(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)N(C)C(CC(C)C)C(=O)NCC(=O)N)C)CC(=O)N)CCC(=O)N
CHEMBL3813883 oxyr_human Human No 8.4 EC50 = 4.2 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1020 17 9 14 -1.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)N(C(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)N(C)C(CC(C)C)C(=O)NCC(=O)N)C)CC(=O)N)CCC(=O)N
CHEMBL24781 oxyr_human Human Yes 8.3 EC50 = 4.6 Funct
Activity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assayActivity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
508 5 0 6 3.0 CC(=O)N1CCC(CC1)OC2=CC(=C(C=C2)C(=O)N3CCC(CC3)N4C5=CC=CC=C5COC4=O)OC
CHEMBL24781 oxyr_human Human Yes 8.3 EC50 = 4.6 Funct
Activity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assayActivity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
508 5 0 6 3.0 CC(=O)N1CCC(CC1)OC2=CC(=C(C=C2)C(=O)N3CCC(CC3)N4C5=CC=CC=C5COC4=O)OC
CHEMBL3814395 oxyr_human Human No 8.3 EC50 = 4.8 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1021 18 12 15 -2.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)NC)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3814395 oxyr_human Human No 8.3 EC50 = 4.8 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1021 18 12 15 -2.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)NC)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL373742 oxyr_human Human Yes 7.4 EC50 = 41 Funct
Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assayActivity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay
1084 19 14 16 -4.8 C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N
CHEMBL3301668 oxyr_human Human Yes 7.4 EC50 = 41 Funct
Agonist activity at human OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayAgonist activity at human OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
988 18 10 13 -1.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OC)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL373742 oxyr_human Human Yes 7.4 EC50 = 41 Funct
Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assayActivity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay
1084 19 14 16 -4.8 C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N
CHEMBL3763342 oxyr_human Human Yes 6.4 EC50 = 420 Funct
Agonist activity at human OTR expressed in HEK293 cells assessed as induction of IP1 accumulation after 1 hr by HTRF assayAgonist activity at human OTR expressed in HEK293 cells assessed as induction of IP1 accumulation after 1 hr by HTRF assay
582 5 4 7 2.2 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCN(CC5)CC6=CC(=CC(=C6)O)O
CHEMBL3763342 oxyr_human Human Yes 6.4 EC50 = 420 Funct
Agonist activity at human oxytocin receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed by addition of Ab-Cryptate and IP1-d2 by HTRF assayAgonist activity at human oxytocin receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed by addition of Ab-Cryptate and IP1-d2 by HTRF assay
582 5 4 7 2.2 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCN(CC5)CC6=CC(=CC(=C6)O)O
CHEMBL3763342 oxyr_human Human Yes 6.4 EC50 = 420 Funct
Agonist activity at human oxytocin receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed by addition of Ab-Cryptate and IP1-d2 by HTRF assayAgonist activity at human oxytocin receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed by addition of Ab-Cryptate and IP1-d2 by HTRF assay
582 5 4 7 2.2 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCN(CC5)CC6=CC(=CC(=C6)O)O
CHEMBL1817708 oxyr_human Human No 7.4 EC50 = 43.7 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1062 22 12 15 -1.9 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCCNCCC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL362483 oxyr_human Human No 6.4 EC50 = 430 Funct
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
604 5 1 6 3.5 CN1CCCN(CC1)C(=S)C2CC(CN2C(=O)NCC3=C(C=C(C=C3)C(=O)N4CCCCC5=C4C=CS5)Cl)OC
CHEMBL362483 oxyr_human Human No 6.4 EC50 = 430 Funct
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
604 5 1 6 3.5 CN1CCCN(CC1)C(=S)C2CC(CN2C(=O)NCC3=C(C=C(C=C3)C(=O)N4CCCCC5=C4C=CS5)Cl)OC
CHEMBL1817708 oxyr_human Human No 7.4 EC50 = 44 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1062 22 12 15 -1.9 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCCNCCC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1817708 oxyr_human Human No 7.4 EC50 = 44 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1062 22 12 15 -1.9 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCCNCCC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3342795 oxyr_human Human No 7.3 EC50 = 47 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
400 5 1 9 3.7 C1=CC=NC(=C1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)SC(F)(F)F
CHEMBL3342795 oxyr_human Human No 7.3 EC50 = 47 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
400 5 1 9 3.7 C1=CC=NC(=C1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)SC(F)(F)F
CHEMBL182627 oxyr_human Human No 6.3 EC50 = 470 Funct
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
612 8 2 6 4.1 COC1CC(N(C1)C(=O)NCC2=C(C=C(C=C2)C(=O)N3CCCCC4=C3C=CS4)Cl)C(=S)NCCC5=CC=CC=N5
CHEMBL182627 oxyr_human Human No 6.3 EC50 = 470 Funct
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
612 8 2 6 4.1 COC1CC(N(C1)C(=O)NCC2=C(C=C(C=C2)C(=O)N3CCCCC4=C3C=CS4)Cl)C(=S)NCCC5=CC=CC=N5
CHEMBL181487 oxyr_human Human No 6.3 EC50 = 480 Funct
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
644 6 1 6 4.4 COC1CC(N(C1)C(=O)NCC2=C(C=C(C=C2)C(=O)N3CCCCC4=C3C=CS4)Cl)C(=S)N5CCC(CC5)N6CCCC6
CHEMBL181487 oxyr_human Human No 6.3 EC50 = 480 Funct
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
644 6 1 6 4.4 COC1CC(N(C1)C(=O)NCC2=C(C=C(C=C2)C(=O)N3CCCCC4=C3C=CS4)Cl)C(=S)N5CCC(CC5)N6CCCC6
CHEMBL395429 oxyr_human Human Yes 8.3 EC50 = 5 Funct
Agonist activity at wild type OTR (unknown origin) expressed in HEK293 cells assessed as intracellular calcium flux after 3 mins by fluorescence assayAgonist activity at wild type OTR (unknown origin) expressed in HEK293 cells assessed as intracellular calcium flux after 3 mins by fluorescence assay
1007 17 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL395429 oxyr_human Human Yes 8.3 EC50 = 5 Funct
Agonist activity at wild type OTR (unknown origin) expressed in HEK293 cells assessed as intracellular calcium flux after 3 mins by fluorescence assayAgonist activity at wild type OTR (unknown origin) expressed in HEK293 cells assessed as intracellular calcium flux after 3 mins by fluorescence assay
1007 17 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3813722 oxyr_human Human No 8.3 EC50 = 5.5 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1035 17 10 15 -2.2 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)N(C)C(CC(C)C)C(=O)N(C)CC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3813722 oxyr_human Human No 8.3 EC50 = 5.5 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1035 17 10 15 -2.2 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)N(C)C(CC(C)C)C(=O)N(C)CC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3342792 oxyr_human Human No 6.3 EC50 = 520 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
388 4 1 9 3.4 CC1=CSC(=N1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)C(F)(F)F
CHEMBL3342792 oxyr_human Human No 6.3 EC50 = 520 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
388 4 1 9 3.4 CC1=CSC(=N1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)C(F)(F)F
CHEMBL3813729 oxyr_human Human No 8.2 EC50 = 7.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1035 17 10 15 -2.2 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)N(C(CSSCC(C(=O)N(C(C(=O)N1)CC2=CC=C(C=C2)O)C)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)C)CC(=O)N)CCC(=O)N
CHEMBL3813729 oxyr_human Human No 8.2 EC50 = 7.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1035 17 10 15 -2.2 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)N(C(CSSCC(C(=O)N(C(C(=O)N1)CC2=CC=C(C=C2)O)C)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)C)CC(=O)N)CCC(=O)N
CHEMBL3763342 oxyr_human Human Yes 7.2 EC50 = 61 Funct
Agonist activity at recombinant human oxytocin receptor expressed in CHO-DUKX-A2 cells assessed as change in intracellular calcium level by FLIPR assayAgonist activity at recombinant human oxytocin receptor expressed in CHO-DUKX-A2 cells assessed as change in intracellular calcium level by FLIPR assay
582 5 4 7 2.2 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCN(CC5)CC6=CC(=CC(=C6)O)O
CHEMBL3763342 oxyr_human Human Yes 7.2 EC50 = 61 Funct
Agonist activity at recombinant human oxytocin receptor expressed in CHO-DUKX-A2 cells assessed as change in intracellular calcium level by FLIPR assayAgonist activity at recombinant human oxytocin receptor expressed in CHO-DUKX-A2 cells assessed as change in intracellular calcium level by FLIPR assay
582 5 4 7 2.2 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCN(CC5)CC6=CC(=CC(=C6)O)O
CHEMBL3763342 oxyr_human Human Yes 7.2 EC50 = 61.3 Funct
Agonist activity at recombinant human OTR expressed in CHO-DUKX-A2 cells assessed as stimulation of intracellular calcium concentration by calcium 3 dye based FLIPR assayAgonist activity at recombinant human OTR expressed in CHO-DUKX-A2 cells assessed as stimulation of intracellular calcium concentration by calcium 3 dye based FLIPR assay
582 5 4 7 2.2 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCN(CC5)CC6=CC(=CC(=C6)O)O
CHEMBL3763342 oxyr_human Human Yes 7.2 EC50 = 61.3 Funct
Agonist activity at recombinant human OTR expressed in CHO-K1 cells assessed as induction of Ca2+ mobilization after overnight incubation by FLIPR assayAgonist activity at recombinant human OTR expressed in CHO-K1 cells assessed as induction of Ca2+ mobilization after overnight incubation by FLIPR assay
582 5 4 7 2.2 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCN(CC5)CC6=CC(=CC(=C6)O)O
CHEMBL3301668 oxyr_mouse Mouse Yes 7.2 EC50 = 62 Funct
Agonist activity at mouse OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayAgonist activity at mouse OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
988 18 10 13 -1.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSCCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OC)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL603708 oxyr_human Human No 7.2 EC50 = 63 Funct
Activity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assayActivity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
447 4 1 2 6.1 C1CCN(C2=CC=CC=C2C1)C(=O)C3=CC=C(C=C3)NC(=O)C4=CC=CC=C4C5=CC=CC=C5
CHEMBL603708 oxyr_human Human No 7.2 EC50 = 63 Funct
Activity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assayActivity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
447 4 1 2 6.1 C1CCN(C2=CC=CC=C2C1)C(=O)C3=CC=C(C=C3)NC(=O)C4=CC=CC=C4C5=CC=CC=C5
CHEMBL365862 oxyr_human Human No 6.2 EC50 = 640 Funct
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
554 4 1 5 3.7 CC1=C(C=CC(=C1)C(=O)N2CCCCC3=C2C=CS3)CNC(=O)N4CCCC4C(=S)N5CCCN(CC5)C
CHEMBL365862 oxyr_human Human No 6.2 EC50 = 640 Funct
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
554 4 1 5 3.7 CC1=C(C=CC(=C1)C(=O)N2CCCCC3=C2C=CS3)CNC(=O)N4CCCC4C(=S)N5CCCN(CC5)C
CHEMBL3813982 oxyr_human Human No 8.1 EC50 = 8.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1020 17 9 14 -1.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)N(C(CSSCCC(=O)N(C(C(=O)N1)CC2=CC=C(C=C2)O)C)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)C)CC(=O)N)CCC(=O)N
CHEMBL3813982 oxyr_human Human No 8.1 EC50 = 8.0 Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1020 17 9 14 -1.4 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)N(C(CSSCCC(=O)N(C(C(=O)N1)CC2=CC=C(C=C2)O)C)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)C)CC(=O)N)CCC(=O)N
CHEMBL1819440 oxyr_human Human Yes 7.2 EC50 = 70.8 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1042 18 13 16 -4.2 C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)NC(CCCN)C(=O)NCC(=O)N
CHEMBL1819440 oxyr_human Human Yes 7.2 EC50 = 71 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1042 18 13 16 -4.2 C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)NC(CCCN)C(=O)NCC(=O)N
CHEMBL1819440 oxyr_human Human Yes 7.2 EC50 = 71 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1042 18 13 16 -4.2 C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)NC(CCCN)C(=O)NCC(=O)N
CHEMBL1429 oxyr_human Human Yes 7.1 EC50 = 72 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1069 19 13 15 -4.0 C1CC(N(C1)C(=O)C2CSSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N
CHEMBL1429 oxyr_human Human Yes 7.1 EC50 = 72 Funct
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1069 19 13 15 -4.0 C1CC(N(C1)C(=O)C2CSSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N
CHEMBL3342797 oxyr_human Human No 6.1 EC50 = 753 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
432 5 1 10 2.5 C1=CC=NC(=C1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)S(=O)(=O)C(F)(F)F
CHEMBL3342797 oxyr_human Human No 6.1 EC50 = 753 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
432 5 1 10 2.5 C1=CC=NC(=C1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)S(=O)(=O)C(F)(F)F
CHEMBL1817759 oxyr_human Human No 6.1 EC50 = 776.3 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
954 16 12 16 -5.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CO2)N)C(=O)N3CCCC3C(=O)NC(CCN)C(=O)NCC(=O)N)CC(=O)N)CC(=O)N
CHEMBL3763342 oxyr_mouse Mouse Yes 7.1 EC50 = 78 Funct
Agonist activity at mouse OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayAgonist activity at mouse OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
582 5 4 7 2.2 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCN(CC5)CC6=CC(=CC(=C6)O)O
CHEMBL1817759 oxyr_human Human No 6.1 EC50 = 780 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
954 16 12 16 -5.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CO2)N)C(=O)N3CCCC3C(=O)NC(CCN)C(=O)NCC(=O)N)CC(=O)N)CC(=O)N
CHEMBL1817759 oxyr_human Human No 6.1 EC50 = 780 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
954 16 12 16 -5.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CO2)N)C(=O)N3CCCC3C(=O)NC(CCN)C(=O)NCC(=O)N)CC(=O)N)CC(=O)N
CHEMBL3342790 oxyr_human Human No 8.1 EC50 = 8 Funct
Agonist activity at human OTR expressed in HEK293 cell membranes induction of IP1 accumulation at 0.1 to 10 uM measured after 1 hr by fluorescence assayAgonist activity at human OTR expressed in HEK293 cell membranes induction of IP1 accumulation at 0.1 to 10 uM measured after 1 hr by fluorescence assay
368 4 1 8 2.9 C1=CC=NC(=C1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)C(F)(F)F
CHEMBL3342790 oxyr_human Human No 8.1 EC50 = 8 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
368 4 1 8 2.9 C1=CC=NC(=C1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)C(F)(F)F
CHEMBL395429 oxyr_human Human Yes 8.1 EC50 = 8 Funct
Agonist activity at SNAP-tagged oxytocin receptor (unknown origin) expressed in HEK293 cells assessed as intracellular calcium flux after 3 mins by fluorescence assayAgonist activity at SNAP-tagged oxytocin receptor (unknown origin) expressed in HEK293 cells assessed as intracellular calcium flux after 3 mins by fluorescence assay
1007 17 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL3342790 oxyr_human Human No 8.1 EC50 = 8 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
368 4 1 8 2.9 C1=CC=NC(=C1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)C(F)(F)F
CHEMBL373742 oxyr_human Human Yes 8.1 EC50 = 8.3 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assayAgonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay
1084 19 14 16 -4.8 C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N
CHEMBL373742 oxyr_human Human Yes 8.1 EC50 = 8.3 Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assayAgonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay
1084 19 14 16 -4.8 C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N
CHEMBL185152 oxyr_human Human No 6.1 EC50 = 810 Funct
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
574 4 1 5 4.0 CN1CCCN(CC1)C(=S)C2CCCN2C(=O)NCC3=C(C=C(C=C3)C(=O)N4CCCCC5=C4C=CS5)Cl
CHEMBL185152 oxyr_human Human No 6.1 EC50 = 810 Funct
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
574 4 1 5 4.0 CN1CCCN(CC1)C(=S)C2CCCN2C(=O)NCC3=C(C=C(C=C3)C(=O)N4CCCCC5=C4C=CS5)Cl
CHEMBL1817763 oxyr_human Human No 6.1 EC50 = 860 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1026 19 12 16 -3.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CS2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CC(=O)N
CHEMBL1817763 oxyr_human Human No 6.1 EC50 = 860 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1026 19 12 16 -3.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CS2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CC(=O)N
CHEMBL1817763 oxyr_human Human No 6.1 EC50 = 871.0 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1026 19 12 16 -3.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CS2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CC(=O)N
CHEMBL3763342 oxyr_human Human Yes 6.1 EC50 = 880 Funct
Agonist activity at C-terminal GFP-tagged OTR (unknown origin) expressed in HEK293 cells measured after 18 hrs by luciferase reporter gene assayAgonist activity at C-terminal GFP-tagged OTR (unknown origin) expressed in HEK293 cells measured after 18 hrs by luciferase reporter gene assay
582 5 4 7 2.2 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCN(CC5)CC6=CC(=CC(=C6)O)O
CHEMBL3763342 oxyr_human Human Yes 6.1 EC50 = 881 Funct
Agonist activity at human OTR stably expressed in HEK cells by calcium flux assayAgonist activity at human OTR stably expressed in HEK cells by calcium flux assay
582 5 4 7 2.2 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCN(CC5)CC6=CC(=CC(=C6)O)O
CHEMBL395429 oxyr_human Human Yes 8.1 EC50 = 9 Funct
Agonist activity at C-terminal GFP-tagged OTR (unknown origin) expressed in HEK293 cells measured after 18 hrs by luciferase reporter gene assayAgonist activity at C-terminal GFP-tagged OTR (unknown origin) expressed in HEK293 cells measured after 18 hrs by luciferase reporter gene assay
1007 17 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1819543 oxyr_human Human No 8.0 EC50 = 9.1 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
978 17 12 15 -4.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1819543 oxyr_human Human No 8.0 EC50 = 9.1 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
978 17 12 15 -4.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1819543 oxyr_human Human No 8.0 EC50 = 9.1 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
978 17 12 15 -4.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCN)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL1817758 oxyr_human Human No 6.0 EC50 = 970 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1010 19 12 16 -4.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CO2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CC(=O)N
CHEMBL1817758 oxyr_human Human No 6.0 EC50 = 970 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1010 19 12 16 -4.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CO2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CC(=O)N
CHEMBL1817758 oxyr_human Human No 6.0 EC50 = 977.2 Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1010 19 12 16 -4.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CO2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CC(=O)N
CHEMBL3142790 oxyr_human Human No 9.5 IC50 = 0.3 Funct
Ability to inhibit OT-induced inositol phosphate accumulation was determined in CHO cells expressing the human OT receptorAbility to inhibit OT-induced inositol phosphate accumulation was determined in CHO cells expressing the human OT receptor
1378 36 13 18 1.7 CCC(C)C(C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(CS)C(=O)N1CCCC1C(=O)NC(CCCN)C(=O)NC(CC2=CC(=C(C=C2)N=[N+]=[N-])I)C(=O)N)NC(=O)C(CC3=CC=C(C=C3)OC)NC(=O)CC4(CCCCC4)SCCC(=O)N
CHEMBL338711 oxyr_rat Rat No 9.2 IC50 = 0.7 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
688 11 2 8 2.9 CC1(C2CCC1(C(C2)NC(=O)C(CCS(=O)(=O)C)NC(=O)CC3=CN(C=N3)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL285608 oxyr_human Human No 9.0 IC50 = 1 Funct
Inhibitory concentration required for antagonist activity against oxytocin receptorInhibitory concentration required for antagonist activity against oxytocin receptor
574 12 3 7 2.0 CC(=O)CCCC(=O)NC1C(=O)N(C2=CC=CC=C2C(=N1)C3=CC=CC=C3)CC(=O)NC(CC4=CC=CS4)C(=O)N
CHEMBL131477 oxyr_rat Rat No 8.9 IC50 = 1.2 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
674 11 3 8 3.0 CC1(C2CCC1(C(C2)NC(=O)C(CCS(=O)(=O)C)NC(=O)CC3=CN=CN3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL2112895 oxyr_rat Rat No 8.9 IC50 = 1.3 Funct
Displacement of [3H]OT from binding to oxytocin receptor of rat uterusDisplacement of [3H]OT from binding to oxytocin receptor of rat uterus
638 11 3 9 2.7 CC1=CC=CC=C1N2CCN(CC2)S(=O)(=O)CC34CCC(C3(C)C)CC4NC(=O)C(CCS(=O)(=O)C)NC5CCNCC5
CHEMBL2112893 oxyr_rat Rat No 8.9 IC50 = 1.4 Funct
Displacement of [3H]OT from binding to oxytocin receptor of rat uterusDisplacement of [3H]OT from binding to oxytocin receptor of rat uterus
687 11 2 10 2.5 CC1=CC=CC=C1N2CCN(CC2)S(=O)(=O)CC34CCC(C3(C)C)CC4NC(=O)C(CCS(=O)(=O)C)NC5CCS(=O)(=O)CC5
CHEMBL338921 oxyr_rat Rat No 8.8 IC50 = 1.7 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
653 11 3 7 2.4 CC1(C2CCC1(C(C2)NC(=O)C(CCC(=O)N)NC(=O)CC3=CN(C=N3)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL2112247 oxyr_rat Rat No 8.0 IC50 = 10 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
770 6 4 7 2.9 CCC(C)C1C(=O)N2CCCCC2C(=O)N3CCCCC3C(=O)NC(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CN(C6=CC=CC=C65)C)CC7=CN=CN7
CHEMBL279281 oxyr_rat Rat No 8.0 IC50 = 10 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
558 7 2 7 3.1 CC(CNC1CC(=O)N(C1=O)C2CC3CCC2(C3(C)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)O
CHEMBL132391 oxyr_rat Rat No 7.0 IC50 = 100 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
596 8 2 6 4.8 CC1(C2CCC1(C(C2)(CCNC(=O)CC3CN4CCC3CC4)O)CS(=O)(=O)N5CCC6(CC5)C=CC7=CC=CC=C67)C
CHEMBL130768 oxyr_rat Rat No 7.0 IC50 = 100 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
472 4 1 4 3.9 CC1(C2CCC1(C(C2)N3CCNC3=O)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL128726 oxyr_rat Rat No 7.0 IC50 = 100 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
536 6 2 6 3.8 CC1(C2CCC1(C(C2)(CNC(=O)C3=CN=CC=C3)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL340362 oxyr_rat Rat No 7.0 IC50 = 100 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
578 6 2 7 3.3 CC1(C2CCC1(C(C2)NC(=O)C3CC(CN3)S(=O)(=O)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL237772 oxyr_human Human No 6.0 IC50 = 1000 Funct
Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsDisplacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cells
490 3 1 4 4.1 CC1=C(C=C(C=C1)F)C(=O)NC2=CC(=C(C=C2)C(=O)N3CC4C=CC(=O)N4CC5=CC=CC=C53)Cl
CHEMBL237987 oxyr_human Human No 6.0 IC50 = 1000 Funct
Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsDisplacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cells
427 5 3 5 4.8 CC1=C(C=C(C=C1)F)C(=O)NC2=CC(=C(C=C2)C(=O)NC3=CC=CC=C3C(=O)O)Cl
CHEMBL238206 oxyr_human Human No 6.0 IC50 = 1000 Funct
Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsDisplacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cells
506 7 3 5 4.9 CC1=C(C=C(C=C1)F)C(=O)NC2=CC(=C(C=C2)C(=O)NC3=CC=CC=C3CN4C=CC=C4C(=O)O)Cl
CHEMBL392363 oxyr_human Human No 6.0 IC50 = 1000 Funct
Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsDisplacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cells
490 3 1 4 3.9 CC1=C(C=C(C=C1)F)C(=O)NC2=CC(=C(C=C2)C(=O)N3C=C4CCC(=O)N4CC5=CC=CC=C53)Cl
CHEMBL237772 oxyr_human Human No 6.0 IC50 = 1000 Funct
Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsDisplacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cells
490 3 1 4 4.1 CC1=C(C=C(C=C1)F)C(=O)NC2=CC(=C(C=C2)C(=O)N3CC4C=CC(=O)N4CC5=CC=CC=C53)Cl
CHEMBL237987 oxyr_human Human No 6.0 IC50 = 1000 Funct
Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsDisplacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cells
427 5 3 5 4.8 CC1=C(C=C(C=C1)F)C(=O)NC2=CC(=C(C=C2)C(=O)NC3=CC=CC=C3C(=O)O)Cl
CHEMBL238206 oxyr_human Human No 6.0 IC50 = 1000 Funct
Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsDisplacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cells
506 7 3 5 4.9 CC1=C(C=C(C=C1)F)C(=O)NC2=CC(=C(C=C2)C(=O)NC3=CC=CC=C3CN4C=CC=C4C(=O)O)Cl
CHEMBL392363 oxyr_human Human No 6.0 IC50 = 1000 Funct
Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsDisplacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cells
490 3 1 4 3.9 CC1=C(C=C(C=C1)F)C(=O)NC2=CC(=C(C=C2)C(=O)N3C=C4CCC(=O)N4CC5=CC=CC=C53)Cl
CHEMBL126709 oxyr_rat Rat No 6.0 IC50 = 1000 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
418 3 1 4 4.6 CC1(C2CCC1(C(C2)O)CS(=O)(=O)N3CCC4(CCCC5=CC=CC=C54)CC3)C
CHEMBL131613 oxyr_rat Rat No 6.0 IC50 = 1000 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
521 6 1 4 5.7 CC1(C2CCC1(C(C2)NC(=O)CC3=CC=CC=C3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL340772 oxyr_rat Rat No 6.0 IC50 = 1000 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
507 5 1 4 5.7 CC1(C2CCC1(C(C2)NC(=O)C3=CC=CC=C3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL340383 oxyr_rat Rat No 5.0 IC50 = 10000 Funct
Compound was evaluated for half-maximal inhibition of binding of [3H]oxytocin to Oxytocin receptor in rat uterine tissueCompound was evaluated for half-maximal inhibition of binding of [3H]oxytocin to Oxytocin receptor in rat uterine tissue
351 3 0 3 4.3 C1CN(CCC12C=CC3=CC=CC=C23)S(=O)(=O)C=CC4=CC=CC=C4
CHEMBL340149 oxyr_rat Rat No 5.0 IC50 = 10000 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
318 1 1 1 4.2 CC1=CC=C(C=C1)NC(=O)N2CCC3(CC2)C=CC4=CC=CC=C34
CHEMBL127119 oxyr_rat Rat No 5.0 IC50 = 10000 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
363 1 1 1 4.7 C1CN(CCC12C=CC3=CC=CC=C23)C(=O)NC4C5CC6CC(C5)CC4C6
CHEMBL126796 oxyr_rat Rat No 5.0 IC50 = 10000 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
331 2 0 4 3.9 C1CN(CCC12C=CC3=CC=CC=C23)S(=O)(=O)C4=CC=CS4
CHEMBL125358 oxyr_rat Rat No 5.0 IC50 = 10000 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
325 2 0 3 3.8 C1CN(CCC12C=CC3=CC=CC=C23)S(=O)(=O)C4=CC=CC=C4
CHEMBL129413 oxyr_rat Rat No 5.0 IC50 = 10000 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
289 1 0 1 4.2 C1CN(CCC12C=CC3=CC=CC=C23)C(=O)C4=CC=CC=C4
CHEMBL337976 oxyr_rat Rat No 5.0 IC50 = 10000 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
304 1 1 1 3.9 C1CN(CCC12C=CC3=CC=CC=C23)C(=O)NC4=CC=CC=C4
CHEMBL338605 oxyr_rat Rat No 5.0 IC50 = 10000 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
339 2 0 3 4.2 CC1=CC=CC=C1S(=O)(=O)N2CCC3(CC2)C=CC4=CC=CC=C34
CHEMBL274955 oxyr_rat Rat No 5.0 IC50 = 10000 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
431 4 2 5 2.9 CC1(C2CCC1(C(C2)(CN)O)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL338362 oxyr_rat Rat No 5.0 IC50 = 10000 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
511 6 2 5 3.8 CC1(C2CCC1(C(C2)NC(=O)CC3=CN=CN3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL415418 oxyr_human Human Yes 7.0 IC50 = 103 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1054 17 11 14 -0.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CC4=CC=CC=C4CC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL415418 oxyr_human Human Yes 7.0 IC50 = 103 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1054 17 11 14 -0.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CC4=CC=CC=C4CC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL603708 oxyr_human Human No 7.0 IC50 = 109 Funct
Antagonist activity at OXR receptor (unknown origin)Antagonist activity at OXR receptor (unknown origin)
447 4 1 2 6.1 C1CCN(C2=CC=CC=C2C1)C(=O)C3=CC=C(C=C3)NC(=O)C4=CC=CC=C4C5=CC=CC=C5
CHEMBL435019 oxyr_rat Rat No 8.0 IC50 = 11 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
485 4 0 5 3.7 CC1(C2CCC1(C(C2)N3C(=O)CCC3=O)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL339497 oxyr_rat Rat No 8.0 IC50 = 11 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
617 9 2 7 3.6 CC1(C2CCC1(C(C2)NC(=O)C(CCS(=O)(=O)C)C3=CN=CN3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL128216 oxyr_rat Rat No 7.0 IC50 = 110 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
513 5 1 6 2.8 CC1(C2CCC1(C(C2)(CN3C(=O)CCC3=O)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL131168 oxyr_rat Rat No 7.0 IC50 = 110 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
502 6 2 5 4.5 CC(C)C(C(=O)NC1CC2CCC1(C2(C)C)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)N
CHEMBL131388 oxyr_rat Rat No 7.0 IC50 = 110 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
594 9 3 8 2.0 CC1(C2CCC1(C(C2)(CNC(=O)C(CCS(=O)(=O)C)N)O)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL336992 oxyr_rat Rat No 7.0 IC50 = 110 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
590 6 2 5 4.9 CC1(C2CCC1(C(C2)NC(=O)CC3=C(N=CN3)Br)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL334610 oxyr_rat Rat No 7.0 IC50 = 110 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
542 6 3 6 3.2 CC1(C2CCC1(C(C2)(CNC(=O)C3CCCNC3)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL422080 oxyr_rat Rat No 7.0 IC50 = 110 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
564 8 2 6 4.6 CC1(C2CCC1(C(C2)(CCNC(=O)CC3=CC=NC=C3)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL129268 oxyr_rat Rat No 6.0 IC50 = 1100 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
402 3 0 4 3.8 CC1(C2CCC1(C(=O)C2)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL126717 oxyr_rat Rat No 6.0 IC50 = 1100 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
416 3 0 4 4.3 CC1(C2CCC1(C(=O)C2)CS(=O)(=O)N3CCC4(CCCC5=CC=CC=C54)CC3)C
CHEMBL382301 oxyr_rat Rat Yes 7.9 IC50 = 12 Funct
Antagonism of OT-induced response at OT receptor in rat uterine stripsAntagonism of OT-induced response at OT receptor in rat uterine strips
994 18 11 15 -1.9 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)N3CCCC3C(=O)NC(CCCN)C(=O)NCC(=O)N)CC(=O)N)C(C)O
CHEMBL382301 oxyr_rat Rat Yes 7.9 IC50 = 12 Funct
Antagonism of OT-induced response at OT receptor in rat uterine stripsAntagonism of OT-induced response at OT receptor in rat uterine strips
994 18 11 15 -1.9 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)N3CCCC3C(=O)NC(CCCN)C(=O)NCC(=O)N)CC(=O)N)C(C)O
CHEMBL2112899 oxyr_rat Rat No 7.9 IC50 = 12 Funct
Displacement of [3H]OT from binding to oxytocin receptor of rat uterusDisplacement of [3H]OT from binding to oxytocin receptor of rat uterus
531 8 3 6 2.4 CC1(C2CCC1(C(C2)NC(=O)C(CCC(=O)N)N)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL2112902 oxyr_rat Rat No 7.9 IC50 = 12 Funct
Displacement of [3H]OT from binding to oxytocin receptor of rat uterusDisplacement of [3H]OT from binding to oxytocin receptor of rat uterus
566 8 2 7 2.9 CC1(C2CCC1(C(C2)NC(=O)C(CCS(=O)(=O)C)N)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL276990 oxyr_rat Rat No 7.9 IC50 = 12 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
500 4 1 6 2.9 CC1(C2CCC1(C(C2)N3C(=O)CC(C3=O)N)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL2112666 oxyr_rat Rat No 7.9 IC50 = 12 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
566 8 2 7 2.9 CC1(C2CCC1(C(C2)NC(=O)C(CCS(=O)(=O)C)N)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL341049 oxyr_rat Rat No 7.9 IC50 = 12 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
566 6 1 6 3.5 CC1(C2CCC1(C(C2)N3C(=O)CN(C3=O)CC4=CN=CN4)CS(=O)(=O)N5CCC6(CCC7=CC=CC=C76)CC5)C
CHEMBL130742 oxyr_rat Rat No 7.9 IC50 = 12 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
531 8 3 6 2.4 CC1(C2CCC1(C(C2)NC(=O)C(CCC(=O)N)N)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL128398 oxyr_rat Rat No 6.9 IC50 = 120 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
511 6 1 5 4.0 CC1(C2CCC1(C(C2)NC(=O)CN3C=CN=C3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL131269 oxyr_rat Rat No 6.9 IC50 = 120 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
522 6 1 5 4.6 CC1(C2CCC1(C(C2)NC(=O)CC3=CC=NC=C3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL338636 oxyr_rat Rat No 6.9 IC50 = 120 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
550 7 2 6 5.0 CC1(C2CCC1(C(C2)(CCNC(=O)C3=CC=CC=N3)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL339493 oxyr_rat Rat No 5.9 IC50 = 1200 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
665 4 2 6 3.2 CCC(C)C1C(=O)N2CCCCC2C(=O)N3CCCCC3C(=O)N(C(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CC=CC=C5)C)C
CHEMBL338757 oxyr_rat Rat No 5.9 IC50 = 1200 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
404 2 0 3 4.5 C1CN(CCC12C=CC3=CC=CC=C23)S(=O)(=O)C4=CC=C(C=C4)Br
CHEMBL340320 oxyr_rat Rat No 5.9 IC50 = 1200 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
445 4 1 4 4.1 CC(=O)NC1CC2CCC1(C2(C)C)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3
CHEMBL337519 oxyr_rat Rat No 5.9 IC50 = 1200 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
511 6 2 5 3.8 CC1(C2CCC1(C(C2)NC(=O)CC3=CN=CN3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL336362 oxyr_rat Rat No 4.9 IC50 = 12000 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
579 6 1 4 7.5 CC1(C2CCC1(C(C2)NC(=O)CC34CC5CC(C3)CC(C5)C4)CS(=O)(=O)N6CCC7(CCC8=CC=CC=C87)CC6)C
CHEMBL280202 oxyr_rat Rat No 6.9 IC50 = 124 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
556 7 0 6 4.6 CCN(CC)C1CC(=O)N(C1=O)C2CC3CCC2(C3(C)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4
CHEMBL201889 oxyr_rat Rat No 5.9 IC50 = 1259 Funct
Antagonism of OT-induced response at OT receptor in rat uterine stripsAntagonism of OT-induced response at OT receptor in rat uterine strips
449 2 1 7 4.6 CC1=NN(C=C1)C2=CC(=C(C=C2)C(=O)N3CC4=C(NC5=CC=CC=C53)N=CC=C4)C(F)(F)F
CHEMBL201889 oxyr_rat Rat No 5.9 IC50 = 1259 Funct
Antagonism of OT-induced response at OT receptor in rat uterine stripsAntagonism of OT-induced response at OT receptor in rat uterine strips
449 2 1 7 4.6 CC1=NN(C=C1)C2=CC(=C(C=C2)C(=O)N3CC4=C(NC5=CC=CC=C53)N=CC=C4)C(F)(F)F
CHEMBL338018 oxyr_rat Rat No 7.9 IC50 = 13 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
808 10 4 7 5.1 CCC(C)C1C(=O)N2CCCCC2C(=O)NC(C(=O)N(C(C(=O)N3CCCC3C(=O)NC(C(=O)N1)CC4=CC5=CC=CC=C5C=C4)CC6=CC=CC=C6)C)CCCCN
CHEMBL277022 oxyr_rat Rat No 7.9 IC50 = 13 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
572 8 1 8 3.3 CC1(C2CCC1(C(C2)N3C(=O)CC(C3=O)NCC(=O)OC)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL128258 oxyr_rat Rat No 7.9 IC50 = 13 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
593 7 2 8 2.8 CC1(C2CCC1(C(C2)N3C(=O)C(NC3=O)CCS(=O)(=O)N)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL405016 oxyr_rat Rat No 7.9 IC50 = 13 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
610 7 2 9 2.4 CC1(C2CCC1(C(C2)N3C(=O)CC(C3=O)CC(=O)NC4=NNN=N4)CS(=O)(=O)N5CCC6(CCC7=CC=CC=C76)CC5)C
CHEMBL397407 oxyr_human Human Yes 6.9 IC50 = 130 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1069 17 12 15 -1.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CC4=CC=CC=C4CC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL280678 oxyr_human Human No 6.9 IC50 = 130 Funct
Antagonistic activity against Oxytocin receptorAntagonistic activity against Oxytocin receptor
572 7 2 6 4.3 CC(CN1CCCC(C1)C(=O)NC2CC3CCC2(C3(C)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)O
CHEMBL406351 oxyr_human Human No 6.9 IC50 = 130 Funct
Binding affinity towards oxytocin receptorBinding affinity towards oxytocin receptor
1033 9 12 15 -2.4 CCC(C)C1C(=O)NC2CCC(=O)NCCCCC(NC(=O)C3CCCN3C(=O)C(CSSC(C(C(=O)NC(C(=O)N1)CC4=CC=C(C=C4)O)N)(C)C)NC(=O)C(NC2=O)CC(=O)N)C(=O)NCC(=O)N
CHEMBL397407 oxyr_human Human Yes 6.9 IC50 = 130 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1069 17 12 15 -1.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CC4=CC=CC=C4CC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL131239 oxyr_rat Rat No 6.9 IC50 = 130 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
528 6 2 5 4.3 CC1(C2CCC1(C(C2)NC(=O)CC3CCCNC3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL339151 oxyr_rat Rat No 6.9 IC50 = 130 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
473 5 2 5 3.2 CC(=O)NCC1(CC2CCC1(C2(C)C)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)O
CHEMBL127063 oxyr_rat Rat No 5.9 IC50 = 1300 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
414 3 0 4 4.3 CC1C2CCC(C1=O)(C2(C)C)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45
CHEMBL128124 oxyr_rat Rat No 5.9 IC50 = 1300 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
431 4 2 5 2.9 CC1(C2CCC1(C(C2)(CN)O)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL234363 oxyr_human Human Yes 5.9 IC50 = 1380 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1023 19 13 15 -1.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)NC(C(=O)NC(CC(C)C)C(=O)NCC(=O)N)C(C)(C)C)CC(=O)N)CCC(=O)N
CHEMBL234363 oxyr_human Human Yes 5.9 IC50 = 1380 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1023 19 13 15 -1.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)NC(C(=O)NC(CC(C)C)C(=O)NCC(=O)N)C(C)(C)C)CC(=O)N)CCC(=O)N
CHEMBL445816 oxyr_human Human Yes 7.9 IC50 = 14 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
625 14 3 8 4.1 CN(C)CCCNC(=O)CCC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NNC2=C3C=CC=CC3=NC2=O)C4=CC=C(C=C4)Cl
CHEMBL2113201 oxyr_human Human No 7.9 IC50 = 14 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
570 12 2 8 4.6 CN(C)CCCOC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NNC2=C3C=CC=CC3=NC2=O)C4=CC=C(C=C4)Cl
CHEMBL339132 oxyr_rat Rat No 7.9 IC50 = 14 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
500 4 0 5 3.9 CC1(C2CCC1(C(C2)N3C(=O)CN(C3=O)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL128712 oxyr_rat Rat No 7.9 IC50 = 14 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
500 4 1 5 4.1 CC1C(=O)N(C(=O)N1)C2CC3CCC2(C3(C)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4
CHEMBL445816 oxyr_human Human Yes 7.9 IC50 = 14 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
625 14 3 8 4.1 CN(C)CCCNC(=O)CCC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NNC2=C3C=CC=CC3=NC2=O)C4=CC=C(C=C4)Cl
CHEMBL2113201 oxyr_human Human No 7.9 IC50 = 14 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
570 12 2 8 4.6 CN(C)CCCOC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NNC2=C3C=CC=CC3=NC2=O)C4=CC=C(C=C4)Cl
CHEMBL421090 oxyr_rat Rat No 6.9 IC50 = 140 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
525 7 1 5 3.7 CC1(C2CCC1(C(C2)NC(=O)CCN3C=CN=C3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL128328 oxyr_rat Rat No 6.9 IC50 = 140 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
474 6 2 5 3.6 CC1(C2CCC1(C(C2)NC(=O)CCN)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL435613 oxyr_rat Rat No 6.9 IC50 = 140 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
513 6 1 7 3.6 CC1(C2CCC1(C(C2)NC(=O)CN3C=NN=N3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL419422 oxyr_rat Rat No 5.9 IC50 = 1400 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
474 5 2 6 4.5 CC(C(=O)O)C1(CC2CCC1(C2(C)C)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)O
CHEMBL2113189 oxyr_human Human No 7.8 IC50 = 15 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
598 11 2 9 4.4 CN(C)CCCOC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NN=C2C3=CC=CC=C3C(=O)NC2=O)C4=CC=C(C=C4)Cl
CHEMBL2370623 oxyr_rat Rat No 7.8 IC50 = 15 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
740 6 2 7 3.8 CCC(C)C1C(=O)N2C(CCC=N2)C(=O)N3CCCCC3C(=O)N(C(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CC=CC=C5)CC6=CC=CC=C6)C
CHEMBL1790937 oxyr_rat Rat No 7.8 IC50 = 15 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
756 6 5 7 2.9 CCC(C)C1C(=O)N2CCCCC2C(=O)N3CCCCC3C(=O)NC(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CNC6=CC=CC=C65)CC7=CN=CN7
CHEMBL338308 oxyr_rat Rat No 7.8 IC50 = 15 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
743 9 4 8 2.5 CCC(C)C1C(=O)N2C(CCC=N2)C(=O)NC(C(=O)N(C(C(=O)N3CCCC3C(=O)NC(C(=O)N1)CC4=CC=CC=C4)CC5=CC=CC=C5)C)CCCN
CHEMBL2112900 oxyr_rat Rat No 7.8 IC50 = 15 Funct
Displacement of [3H]OT from binding to oxytocin receptor of rat uterusDisplacement of [3H]OT from binding to oxytocin receptor of rat uterus
637 11 2 8 4.4 CC1=CC=CC=C1N2CCN(CC2)S(=O)(=O)CC34CCC(C3(C)C)CC4NC(=O)C(CCS(=O)(=O)C)NC5CCCCC5
CHEMBL278377 oxyr_rat Rat No 7.8 IC50 = 15 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
585 9 1 7 3.8 CC1(C2CCC1(C(C2)N3C(=O)CC(C3=O)NCCCN(C)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL2113189 oxyr_human Human No 7.8 IC50 = 15 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
598 11 2 9 4.4 CN(C)CCCOC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NN=C2C3=CC=CC=C3C(=O)NC2=O)C4=CC=C(C=C4)Cl
CHEMBL283317 oxyr_rat Rat No 6.8 IC50 = 150 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
556 7 0 6 4.6 CCN(CC)C1CC(=O)N(C1=O)C2CC3CCC2(C3(C)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4
CHEMBL435009 oxyr_rat Rat No 6.8 IC50 = 150 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
487 6 2 5 4.1 CC(=O)NCCC1(CC2CCC1(C2(C)C)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)O
CHEMBL339357 oxyr_rat Rat No 6.8 IC50 = 150 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
501 5 1 5 3.5 CC1(C2CCC1(C(C2)(CN3CCCC3=O)O)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL131564 oxyr_rat Rat No 6.8 IC50 = 150 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
539 6 2 5 4.8 CC1(C2CCC1(C(C2)NC(=O)C(C)(C)C3=CN=CN3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL128327 oxyr_rat Rat No 6.8 IC50 = 150 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
511 5 2 5 4.6 CC1=C(N=CN1)C(=O)NC2CC3CCC2(C3(C)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4
CHEMBL131235 oxyr_rat Rat No 6.8 IC50 = 150 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
523 6 2 5 4.3 CC1(C2CCC1(C(C2)NC(=O)C=CC3=CN=CN3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL339452 oxyr_rat Rat No 5.8 IC50 = 1500 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
715 6 2 6 4.3 CCC(C)C1C(=O)N(C(C(=O)N2CCCCC2C(=O)N(C(C(=O)N3CCCC3C(=O)NC(C(=O)N1)CC4=CC=CC=C4)CC5=CC=CC=C5)C)C)C
CHEMBL436397 oxyr_rat Rat No 5.8 IC50 = 1500 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
745 8 4 8 3.3 CCC(C)C1C(=O)N2CCCCC2C(=O)NC(C(=O)N(C(C(=O)N3CCCC3C(=O)NC(C(=O)N1)CC4=CC=CC=C4)CC5=CC=CC=C5)C)CC(=O)O
CHEMBL338576 oxyr_rat Rat No 7.8 IC50 = 16 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
646 10 2 7 3.6 CC1(C2CCC1(C(C2)NC(=O)N(CCC3=CN=CN3)CCS(=O)(=O)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL341289 oxyr_rat Rat No 7.8 IC50 = 16 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
566 6 2 6 3.8 CC1(C2CCC1(C(C2)N3C(=O)C(NC3=O)CC4=CN=CN4)CS(=O)(=O)N5CCC6(CCC7=CC=CC=C76)CC5)C
CHEMBL2369135 oxyr_human Human No 6.8 IC50 = 160 Funct
Binding affinity towards oxytocin receptorBinding affinity towards oxytocin receptor
1089 10 11 15 -1.0 CCC(C)C1C(=O)NC2CCC(=O)NCCCCC(NC(=O)C3CCCN3C(=O)C(CSSC(C(C(=O)NC(C(=O)N1)C(C)C4=C(C=C(C=C4C)OC)C)N)(C)C)NC(=O)C(NC2=O)CC(=O)N)C(=O)NCC(=O)N
CHEMBL338294 oxyr_rat Rat No 6.8 IC50 = 160 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
758 10 4 7 3.9 CCC(C)C1C(=O)N2CCCCC2C(=O)NC(C(=O)N(C(C(=O)N3CCCC3C(=O)NC(C(=O)N1)CC4=CC=CC=C4)CC5=CC=CC=C5)C)CCCCN
CHEMBL423156 oxyr_rat Rat No 6.8 IC50 = 160 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
518 7 2 6 3.8 CC1(C2CCC1(C(C2)NC(=O)NCC(=O)OC)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL126453 oxyr_rat Rat No 4.8 IC50 = 16000 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
370 2 0 5 3.7 C1CN(CCC12C=CC3=CC=CC=C23)S(=O)(=O)C4=CC=C(C=C4)[N+](=O)[O-]
CHEMBL283524 oxyr_rat Rat No 7.8 IC50 = 17 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
501 4 1 6 3.1 CC1(C2CCC1(C(C2)N3C(=O)CC(C3=O)O)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL130803 oxyr_rat Rat No 6.8 IC50 = 170 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
543 6 2 7 4.4 CC1(C2CCC1(C(C2)NC(=O)CC3=CSC(=N3)N)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL131581 oxyr_rat Rat No 6.8 IC50 = 170 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
539 7 2 5 4.8 CCC(C1=CN=CN1)C(=O)NC2CC3CCC2(C3(C)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4
CHEMBL128680 oxyr_rat Rat No 6.8 IC50 = 170 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
522 6 1 5 4.6 CC1(C2CCC1(C(C2)NC(=O)CC3=CN=CC=C3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL128194 oxyr_rat Rat No 6.8 IC50 = 170 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
516 7 2 6 2.9 CC(C(C(=O)C1CC2CCC1(C2(C)C)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)N)C(=O)N
CHEMBL338177 oxyr_rat Rat No 6.8 IC50 = 170 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
556 6 3 5 4.8 CC1(C2CCC1(C(C2)(CNC(=O)NC3CCCCC3)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL127686 oxyr_rat Rat Yes 7.8 IC50 = 18 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
739 6 2 8 2.8 CCC(C)C1C(=O)N2C(CCC=N2)C(=O)N3C(CCC=N3)C(=O)N(C(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CC=CC=C5)CC6=CC=CC=C6)C
CHEMBL1790938 oxyr_rat Rat No 7.8 IC50 = 18 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
770 6 4 7 3.1 CCC(C)C1C(=O)N2CCCCC2C(=O)N3CCCCC3C(=O)N(C(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CNC6=CC=CC=C65)CC7=CN=CN7)C
CHEMBL2112894 oxyr_rat Rat No 7.8 IC50 = 18 Funct
Displacement of [3H]OT from binding to oxytocin receptor of rat uterusDisplacement of [3H]OT from binding to oxytocin receptor of rat uterus
611 12 1 8 3.8 CCN(CC)C(CCS(=O)(=O)C)C(=O)NC1CC2CCC1(C2(C)C)CS(=O)(=O)N3CCN(CC3)C4=CC=CC=C4C
CHEMBL417458 oxyr_rat Rat No 7.8 IC50 = 18 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
571 8 1 7 3.4 CC1(C2CCC1(C(C2)N3C(=O)CC(C3=O)NCCN(C)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL338383 oxyr_rat Rat No 7.8 IC50 = 18 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
486 4 1 5 3.7 CC1(C2CCC1(C(C2)N3C(=O)CNC3=O)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL434993 oxyr_rat Rat No 6.8 IC50 = 180 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
536 7 1 5 4.9 CC1(C2CCC1(C(C2)NC(=O)CCC3=CN=CC=C3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL130887 oxyr_rat Rat No 6.8 IC50 = 180 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
536 6 2 6 4.1 CC1(C2CCC1(C(C2)(CNC(=O)C3=CC=CC=N3)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL339096 oxyr_rat Rat No 6.8 IC50 = 180 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
500 4 1 6 3.8 CC1(C2CCC1(C(C2)N3C(=O)C(=O)NC3=O)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL338635 oxyr_rat Rat No 6.8 IC50 = 180 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
485 4 0 4 4.8 CC1CCC(=O)N1C2CC3CCC2(C3(C)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4
CHEMBL337667 oxyr_rat Rat No 6.8 IC50 = 180 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
536 6 2 6 3.8 CC1(C2CCC1(C(C2)(CNC(=O)C3=CC=NC=C3)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL126962 oxyr_rat Rat No 5.8 IC50 = 1800 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
400 3 0 4 3.7 CC1(C2CCC1(C(=O)C2)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL420144 oxyr_rat Rat No 5.8 IC50 = 1800 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
400 3 0 4 3.7 CC1(C2CCC1(C(=O)C2)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL340388 oxyr_rat Rat No 7.7 IC50 = 19 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
594 8 0 6 3.9 CC1(C2CCC1(C(C2)N3C(=O)CN(C3=O)CCCN4C=CN=C4)CS(=O)(=O)N5CCC6(CCC7=CC=CC=C76)CC5)C
CHEMBL338020 oxyr_rat Rat No 6.7 IC50 = 190 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
756 6 5 7 2.9 CC(C)CC1C(=O)N2CCCCC2C(=O)N3CCCCC3C(=O)NC(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CNC6=CC=CC=C65)CC7=CN=CN7
CHEMBL340479 oxyr_rat Rat No 6.7 IC50 = 190 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
767 8 2 6 5.4 CCC(C)C1C(=O)N2CCCCC2C(=O)N3CCCCC3C(=O)N(C(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CC=CC=C5)CC6=CC=CC=C6)CC=C
CHEMBL276079 oxyr_rat Rat No 6.7 IC50 = 190 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
508 5 1 5 4.7 CC1(C2CCC1(C(C2)NC(=O)C3=CC=NC=C3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL130351 oxyr_rat Rat No 5.7 IC50 = 1900 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
420 3 1 5 4.1 CC1(C2CCC1(C(C2)O)CS(=O)(=O)N3CCC4(CC3)C=CC5=C4C=CC(=C5)F)C
CHEMBL341274 oxyr_rat Rat No 5.7 IC50 = 1900 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
420 3 1 5 4.1 CC1(C2CCC1(C(C2)O)CS(=O)(=O)N3CCC4(CC3)C=CC5=C4C=C(C=C5)F)C
CHEMBL2370761 oxyr_human Human No 4.7 IC50 = 19000 Funct
Binding affinity towards oxytocin receptorBinding affinity towards oxytocin receptor
1089 10 11 15 -1.0 CCC(C)C1C(=O)NC2CCC(=O)NCCCCC(NC(=O)C3CCCN3C(=O)C(CSSC(C(C(=O)NC(C(=O)N1)C(C)C4=C(C=C(C=C4C)OC)C)N)(C)C)NC(=O)C(NC2=O)CC(=O)N)C(=O)NCC(=O)N
CHEMBL2112249 oxyr_rat Rat No 8.7 IC50 = 2.2 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
767 6 4 7 4.0 CCC(C)C1C(=O)N2CCCCC2C(=O)N3CCCCC3C(=O)NC(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CC6=CC=CC=C6C=C5)CC7=CN=CN7
CHEMBL336082 oxyr_rat Rat No 8.7 IC50 = 2.2 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
639 11 4 7 2.4 CC1(C2CCC1(C(C2)NC(=O)C(CCC(=O)N)NC(=O)CC3=CN=CN3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL339929 oxyr_rat Rat No 8.6 IC50 = 2.3 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
653 11 3 7 2.4 CC1(C2CCC1(C(C2)NC(=O)C(CCC(=O)N)NC(=O)CC3=CN=CN3C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL2112897 oxyr_rat Rat No 8.6 IC50 = 2.4 Funct
Displacement of [3H]OT from binding to oxytocin receptor of rat uterusDisplacement of [3H]OT from binding to oxytocin receptor of rat uterus
639 11 2 9 3.0 CC1=CC=CC=C1N2CCN(CC2)S(=O)(=O)CC34CCC(C3(C)C)CC4NC(=O)C(CCS(=O)(=O)C)NC5CCOCC5
CHEMBL130891 oxyr_rat Rat No 8.6 IC50 = 2.6 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
592 7 1 7 3.4 CC1(C2CCC1(C(C2)N3C(=O)C(NC3=O)CCS(=O)(=O)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL395429 oxyr_human Human Yes 8.6 IC50 = 2.7 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1007 17 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL395429 oxyr_human Human Yes 8.6 IC50 = 2.7 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1007 17 12 15 -2.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL2112901 oxyr_rat Rat No 8.6 IC50 = 2.8 Funct
Displacement of [3H]OT from binding to oxytocin receptor of rat uterusDisplacement of [3H]OT from binding to oxytocin receptor of rat uterus
615 12 3 10 1.9 CC1=CC=CC=C1N2CCN(CC2)S(=O)(=O)CC34CCC(C3(C)C)CC4NC(=O)C(CCS(=O)(=O)C)N(CO)CO
CHEMBL2112651 oxyr_rat Rat No 7.7 IC50 = 20 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
780 6 3 6 4.9 CCC(C)C1C(=O)N2CCCCC2C(=O)N3CCCCC3C(=O)N(C(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CNC6=CC=CC=C65)CC7=CC=CC=C7)C
CHEMBL20171 oxyr_rat Rat No 7.7 IC50 = 20 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
558 7 1 7 3.2 CC1(C2CCC1(C(C2)N3C(=O)CC(C3=O)N(C)CCO)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL20319 oxyr_rat Rat No 7.7 IC50 = 20 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
588 8 0 7 4.5 CC1(C2CCC1(C(C2)N3C(=O)CC(C3=O)SCCN(C)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL20757 oxyr_rat Rat No 7.7 IC50 = 20 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
558 7 2 7 3.1 CC(CO)NC1CC(=O)N(C1=O)C2CC3CCC2(C3(C)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4
CHEMBL283994 oxyr_rat Rat No 7.7 IC50 = 20 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
501 4 1 6 3.1 CC1(C2CCC1(C(C2)N3C(=O)CC(C3=O)O)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL128383 oxyr_rat Rat No 7.7 IC50 = 20 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
542 4 1 6 3.4 CC1(C2CCC1(C(C2)N3C(=O)C4CC(CN4C3=O)O)CS(=O)(=O)N5CCC6(CCC7=CC=CC=C76)CC5)C
CHEMBL339118 oxyr_rat Rat No 6.7 IC50 = 200 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
741 6 2 6 4.8 CCC(C)C1C(=O)N2CCCCC2C(=O)N3CCCCC3C(=O)N(C(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CC=CC=C5)CC6=CC=CC=C6)C
CHEMBL281361 oxyr_rat Rat No 6.7 IC50 = 200 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
590 7 1 6 4.9 CC1(C2CCC1(C(C2)N3C(=O)CC(C3=O)NCC4=CC=CC=C4)CS(=O)(=O)N5CCC6(CCC7=CC=CC=C76)CC5)C
CHEMBL341507 oxyr_rat Rat No 6.7 IC50 = 200 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
553 7 3 8 1.9 CC1(C2CCC1(C(C2)NC(=O)C(CS(=O)(=O)N)N)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL340102 oxyr_rat Rat No 5.7 IC50 = 2000 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
418 3 1 4 4.6 CC1(C2CCC1(C(C2)O)CS(=O)(=O)N3CCC4(CCCC5=CC=CC=C54)CC3)C
CHEMBL129983 oxyr_rat Rat No 7.7 IC50 = 21 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
539 4 1 6 3.8 CC1(C2CCC1(C(C2)N3C(=O)C4CCC(=N)N4C3=O)CS(=O)(=O)N5CCC6(CCC7=CC=CC=C76)CC5)C
CHEMBL128388 oxyr_rat Rat No 6.7 IC50 = 210 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
500 5 1 5 4.0 CC1(C2CCC1(C(C2)N3CCC(C3=O)NC)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL326085 oxyr_rat Rat No 4.7 IC50 = 21000 Funct
Compound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissueCompound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissue
428 7 0 7 4.6 CC1=CC(=C2C(=C1)COC(=O)C3=C(O2)C=CC(=C3OC)C(CC(C)C)OC(=O)C)OC
CHEMBL339450 oxyr_rat Rat No 6.7 IC50 = 220 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
767 8 4 7 3.9 CCC(C)C1C(=O)N2CCCCC2C(=O)NC(C(=O)N(C(C(=O)N3CCCC3C(=O)NC(C(=O)N1)CC4=CC=CC=C4)CC5=CC=CC=C5)C)CC6=CN=CN6
CHEMBL276906 oxyr_rat Rat No 6.7 IC50 = 220 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
549 7 2 5 5.7 CC1(C2CCC1(C(C2)(CCNC(=O)C3=CC=CC=C3)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL340334 oxyr_rat Rat No 6.7 IC50 = 220 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
513 6 2 7 3.3 CC1(C2CCC1(C(C2)NC(=O)CC3=NNN=N3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL127118 oxyr_rat Rat No 5.7 IC50 = 2200 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
402 3 1 4 4.0 CC1(C2CCC1(C(C2)O)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL339093 oxyr_rat Rat No 5.7 IC50 = 2200 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
376 6 1 4 3.4 CC1(C2CCC1(C(=O)C2)CS(=O)(=O)NCCC3CCC4=CC=CC=C34)C
CHEMBL128497 oxyr_rat Rat No 5.7 IC50 = 2200 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
402 3 1 4 4.0 CC1(C2CCC1(C(C2)O)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL341021 oxyr_rat Rat No 4.7 IC50 = 22000 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
338 2 0 1 6.3 C1CCCC(CCC1)CC(=O)N2CCC3(CC2)C=CC4=CC=CC=C34
CHEMBL435409 oxyr_rat Rat No 7.6 IC50 = 23 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
612 10 3 7 3.7 CC1(C2CCC1(C(C2)NC(=O)N(CCC3=CN=CN3)CCC(=O)O)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL129498 oxyr_rat Rat No 5.6 IC50 = 2300 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
418 3 0 5 3.8 CC1(C2CCC1(C(=O)C2)CS(=O)(=O)N3CCC4(CC3)C=CC5=C4C=C(C=C5)F)C
CHEMBL338170 oxyr_rat Rat No 5.6 IC50 = 2300 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
418 3 0 5 3.8 CC1(C2CCC1(C(=O)C2)CS(=O)(=O)N3CCC4(CC3)C=CC5=C4C=CC(=C5)F)C
CHEMBL20205 oxyr_rat Rat No 6.6 IC50 = 240 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
483 4 0 5 4.0 CC1(C2CCC1(C(C2)N3C(=O)C=CC3=O)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL340016 oxyr_rat Rat No 6.6 IC50 = 240 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
531 9 1 6 4.2 CCOC(=O)CCC(=O)NC1CC2CCC1(C2(C)C)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3
CHEMBL341267 oxyr_rat Rat No 5.6 IC50 = 2400 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
400 3 0 4 3.7 CC1(C2CCC1(C(=O)C2)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL434193 oxyr_human Human Yes 7.6 IC50 = 25 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1184 18 9 14 1.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)N3CC4=CC=CC=C4CC3C(=O)NC(CC(C)C)C(=O)N5CC6=CC=CC=C6CC5C(=O)N)CC(=O)N)CCC(=O)N
CHEMBL126765 oxyr_rat Rat No 7.6 IC50 = 25 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
782 9 5 8 2.7 CCC(C)C1C(=O)N2C(CCC=N2)C(=O)NC(C(=O)N(C(C(=O)N3CCCC3C(=O)NC(C(=O)N1)CC4=CNC5=CC=CC=C54)CC6=CC=CC=C6)C)CCCN
CHEMBL434193 oxyr_human Human Yes 7.6 IC50 = 25 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1184 18 9 14 1.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)N3CC4=CC=CC=C4CC3C(=O)NC(CC(C)C)C(=O)N5CC6=CC=CC=C6CC5C(=O)N)CC(=O)N)CCC(=O)N
CHEMBL20002 oxyr_rat Rat No 7.6 IC50 = 25 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
543 6 0 7 3.7 CC(=O)OC1CC(=O)N(C1=O)C2CC3CCC2(C3(C)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4
CHEMBL435815 oxyr_rat Rat No 6.6 IC50 = 250 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
521 6 1 4 5.7 CC1(C2CCC1(C(C2)NC(=O)CC3=CC=CC=C3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL338336 oxyr_rat Rat No 5.6 IC50 = 2500 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
402 3 1 4 4.0 CC1(C2CCC1(C(C2)O)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL338221 oxyr_rat Rat No 4.6 IC50 = 25000 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
755 6 1 6 5.0 CCC(C)C1C(=O)N2CCCCC2C(=O)N3CCCCC3C(=O)N(C(C(=O)N4CCCC4C(=O)NC(C(=O)N1C)CC5=CC=CC=C5)CC6=CC=CC=C6)C
CHEMBL130770 oxyr_rat Rat No 6.6 IC50 = 260 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
508 5 1 5 4.7 CC1(C2CCC1(C(C2)NC(=O)C3=CN=CC=C3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL335886 oxyr_rat Rat No 7.6 IC50 = 27 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
627 7 2 7 3.9 CC1(C2CCC1(C(C2)(CNC(=O)C3C[N+]4(CCC3CC4)C(=O)OC)O)CS(=O)(=O)N5CCC6(CC5)C=CC7=CC=CC=C67)C
CHEMBL132064 oxyr_rat Rat No 6.6 IC50 = 270 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
515 5 1 6 4.0 CC1(C2CCC1(C(C2)N3C(CCC3=O)C(=O)O)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL129414 oxyr_rat Rat No 5.6 IC50 = 2700 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
715 6 2 6 4.3 CCC(C)C1C(=O)N2CCCCC2C(=O)N(C(C(=O)N(C(C(=O)N3CCCC3C(=O)NC(C(=O)N1)CC4=CC=CC=C4)CC5=CC=CC=C5)C)C)C
CHEMBL335944 oxyr_rat Rat No 7.5 IC50 = 29 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
540 5 1 5 4.6 CC1(C2CCC1(C(C2)NC(=O)C3CN4CCC3CC4)CS(=O)(=O)N5CCC6(CCC7=CC=CC=C76)CC5)C
CHEMBL433662 oxyr_rat Rat No 8.5 IC50 = 3.2 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
557 7 2 6 2.9 CC1(C2CCC1(C(C2)N3C(=O)C(NC3=O)CCC(=O)N)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL377414 oxyr_human Human No 8.4 IC50 = 3.7 Funct
Agonist activity at human OTR expressed in CHO cells assessed as inhibition of oxytocin-induced calcium mobilization by FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as inhibition of oxytocin-induced calcium mobilization by FLIPR assay
484 6 1 5 4.3 CC(C)CC1C(=O)NC(C(=O)N1C(C2=C(C=C(C=C2)F)F)C(=O)N(C)C)C3CC4=CC=CC=C4C3
CHEMBL377414 oxyr_human Human No 8.4 IC50 = 3.7 Funct
Agonist activity at human OTR expressed in CHO cells assessed as inhibition of oxytocin-induced calcium mobilization by FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as inhibition of oxytocin-induced calcium mobilization by FLIPR assay
484 6 1 5 4.3 CC(C)CC1C(=O)NC(C(=O)N1C(C2=C(C=C(C=C2)F)F)C(=O)N(C)C)C3CC4=CC=CC=C4C3
CHEMBL1254117 oxyr_human Human Yes 7.5 IC50 = 30 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
493 9 2 7 4.3 CCOC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NNC2=C3C=CC=CC3=NC2=O)C4=CC=C(C=C4)C
CHEMBL339155 oxyr_rat Rat No 7.5 IC50 = 30 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
542 7 2 5 4.7 CC1(C2CCC1(C(C2)NC(=O)CCC3CCCNC3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL132157 oxyr_rat Rat No 7.5 IC50 = 30 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
611 7 3 9 2.4 CC1(C2CCC1(C(C2)N3C(=O)C(NC3=O)CC(=O)NC4=NNN=N4)CS(=O)(=O)N5CCC6(CCC7=CC=CC=C76)CC5)C
CHEMBL337221 oxyr_rat Rat No 7.5 IC50 = 30 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
543 6 1 7 3.2 CC1(C2CCC1(C(C2)N3C(=O)CC(C3=O)CC(=O)O)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL338951 oxyr_rat Rat No 7.5 IC50 = 30 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
622 11 1 7 4.6 CCN(CC)C(CCS(=O)(=O)C)C(=O)NC1CC2CCC1(C2(C)C)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3
CHEMBL1254117 oxyr_human Human Yes 7.5 IC50 = 30 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
493 9 2 7 4.3 CCOC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NNC2=C3C=CC=CC3=NC2=O)C4=CC=C(C=C4)C
CHEMBL334332 oxyr_rat Rat No 6.5 IC50 = 300 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
555 8 3 8 3.3 CC1(C2CCC1(C(C2)(CCNC(=O)CC3=NNN=N3)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL125406 oxyr_rat Rat No 5.5 IC50 = 3000 Funct
Compound was evaluated for half-maximal inhibition of binding of [3H]oxytocin to Oxytocin receptor in rat uterine tissueCompound was evaluated for half-maximal inhibition of binding of [3H]oxytocin to Oxytocin receptor in rat uterine tissue
375 2 0 3 5.1 C1CN(CCC12C=CC3=CC=CC=C23)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL126371 oxyr_rat Rat No 5.5 IC50 = 3000 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
404 3 1 4 4.1 CC1(C2CCC(C2)(C1O)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL126565 oxyr_rat Rat No 5.5 IC50 = 3000 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
383 4 0 5 3.7 COC(=O)C1=CC=CC=C1S(=O)(=O)N2CCC3(CC2)C=CC4=CC=CC=C34
CHEMBL340589 oxyr_rat Rat No 5.5 IC50 = 3000 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
487 5 1 5 4.1 CC(C)C(=O)NC1C2CCC(C1=O)(C2(C)C)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3
CHEMBL2112656 oxyr_rat Rat No 4.5 IC50 = 30000 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
699 4 2 6 3.5 CC1C(=O)N2CCCCC2C(=O)N3CCCCC3C(=O)N(C(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CC=CC=C5)CC6=CC=CC=C6)C
CHEMBL335170 oxyr_rat Rat No 4.5 IC50 = 30000 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
403 3 1 4 3.8 CC1(C2CCC1(C(C2)N)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL31065 oxyr_rat Rat No 5.5 IC50 = 3040 Funct
Compound was tested for displacement of 3[H] oxytocin from rat OT receptor (in vitro)Compound was tested for displacement of 3[H] oxytocin from rat OT receptor (in vitro)
609 6 1 9 3.1 C1CN(CCC1N2C3=CC=CC=C3COC2=O)C(=O)C4=CC5=C(C=C4)OC(=C5)CNC(=O)CN6C=C(C=CC6=O)C(F)(F)F
CHEMBL129234 oxyr_rat Rat No 6.5 IC50 = 310 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
509 7 1 6 4.8 CCCS(=O)(=O)NC1CC2CCC1(C2(C)C)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3
CHEMBL2113179 oxyr_human Human No 7.5 IC50 = 32 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
527 10 3 7 4.2 C1=CC2=C(C(=O)N=C2C=C1)NNC(=O)CN(C3=CC=C(C=C3)Cl)S(=O)(=O)C4=CC=C(C=C4)CCCO
CHEMBL20126 oxyr_rat Rat No 7.5 IC50 = 32 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
528 6 1 6 3.8 CCNC1CC(=O)N(C1=O)C2CC3CCC2(C3(C)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4
CHEMBL128652 oxyr_rat Rat No 7.5 IC50 = 32 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
639 11 4 7 2.4 CC1(C2CCC1(C(C2)NC(=O)C(CC3=CN=CN3)NC(=O)CCC(=O)N)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL265073 oxyr_rat Rat No 7.5 IC50 = 32 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
611 10 0 7 3.8 CC1(C2CCC1(C(C2)N(CCC(=O)OC)C(=O)CC3=CN(C=N3)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL2113179 oxyr_human Human No 7.5 IC50 = 32 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
527 10 3 7 4.2 C1=CC2=C(C(=O)N=C2C=C1)NNC(=O)CN(C3=CC=C(C=C3)Cl)S(=O)(=O)C4=CC=C(C=C4)CCCO
CHEMBL337888 oxyr_rat Rat No 6.5 IC50 = 330 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
533 7 2 7 3.4 CC1(C2CCC1(C(C2)NC(=O)C(CC[N+](=O)[O-])N)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL129733 oxyr_rat Rat No 6.5 IC50 = 340 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
727 6 3 6 4.6 CCC(C)C1C(=O)N2CCCCC2C(=O)N3CCCCC3C(=O)NC(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CC=CC=C5)CC6=CC=CC=C6
CHEMBL126999 oxyr_rat Rat No 6.5 IC50 = 340 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
404 3 1 4 4.1 CC1(C2CCC1(C(C2)O)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL52813 oxyr_rat Rat No 5.5 IC50 = 3400 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
713 6 2 6 4.1 CCC(C)C1C(=O)N2CCCC2C(=O)N3CCCC3C(=O)N(C(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CC=CC=C5)CC6=CC=CC=C6)C
CHEMBL269624 oxyr_rat Rat No 5.5 IC50 = 3400 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
428 3 0 4 4.6 CC1(C2CCC(C1=O)(C2(C)C)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL340920 oxyr_rat Rat No 5.5 IC50 = 3400 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
459 4 1 5 3.0 CC(=O)NC1C2CCC(C1=O)(C2(C)C)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3
CHEMBL130905 oxyr_rat Rat No 7.5 IC50 = 35 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
515 5 2 6 3.3 CC1(C2CCC1(C(C2)N3C(=O)C(NC3=O)CN)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL335182 oxyr_rat Rat No 7.5 IC50 = 35 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
550 7 2 6 3.7 CC1(C2CCC1(C(C2)(CNC(=O)CC3=CC=NC=C3)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL130695 oxyr_rat Rat No 6.5 IC50 = 350 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
474 6 1 6 4.2 CC1(C2CCC1(C(C2)(CC(=O)OC)O)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL363910 oxyr_human Human Yes 6.5 IC50 = 353 Funct
Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsDisplacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cells
403 2 0 2 3.9 CC1=NN(C=C1)C2=CC(=C(C=C2)C(=O)N3CC4=CC=CN4CC5=CC=CC=C53)Cl
CHEMBL363910 oxyr_human Human Yes 6.5 IC50 = 353 Funct
Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsDisplacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cells
403 2 0 2 3.9 CC1=NN(C=C1)C2=CC(=C(C=C2)C(=O)N3CC4=CC=CN4CC5=CC=CC=C53)Cl
CHEMBL130476 oxyr_rat Rat No 7.4 IC50 = 36 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
577 6 1 6 4.6 CC1(C2CCC1(C(C2)N3C(=O)C(NC3=O)CC4=CN=CC=C4)CS(=O)(=O)N5CCC6(CCC7=CC=CC=C76)CC5)C
CHEMBL2370768 oxyr_human Human No 4.4 IC50 = 36000 Funct
Binding affinity towards oxytocin receptorBinding affinity towards oxytocin receptor
1089 10 11 15 -1.0 CCC(C)C1C(=O)NC2CCC(=O)NCCCCC(NC(=O)C3CCCN3C(=O)C(CSSC(C(C(=O)NC(C(=O)N1)C(C)C4=C(C=C(C=C4C)OC)C)N)(C)C)NC(=O)C(NC2=O)CC(=O)N)C(=O)NCC(=O)N
CHEMBL132210 oxyr_rat Rat No 7.4 IC50 = 37 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
555 5 2 5 4.5 CC1(C2CCC1(C(C2)NC(=O)NC3CN4CCC3CC4)CS(=O)(=O)N5CCC6(CCC7=CC=CC=C76)CC5)C
CHEMBL125748 oxyr_rat Rat No 5.4 IC50 = 3700 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
414 3 0 4 4.2 CC1CN(CCC12C=CC3=CC=CC=C23)S(=O)(=O)CC45CCC(C4(C)C)CC5=O
CHEMBL382301 oxyr_human Human Yes 6.4 IC50 = 372 Funct
Antagonist activity at human OTR expressed in HEK293 cell membranes assessed as inhibition of OT-induced IP1 accumulation measured after 1 hr by fluorescence assayAntagonist activity at human OTR expressed in HEK293 cell membranes assessed as inhibition of OT-induced IP1 accumulation measured after 1 hr by fluorescence assay
994 18 11 15 -1.9 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)N3CCCC3C(=O)NC(CCCN)C(=O)NCC(=O)N)CC(=O)N)C(C)O
CHEMBL340639 oxyr_rat Rat No 7.4 IC50 = 38 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
567 8 3 8 2.3 CC1(C2CCC1(C(C2)NC(=O)C(CCS(=O)(=O)N)N)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL265630 oxyr_human Human Yes 6.4 IC50 = 380 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1054 17 11 14 -0.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CC4=CC=CC=C4CC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL265630 oxyr_human Human Yes 6.4 IC50 = 380 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1054 17 11 14 -0.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CC4=CC=CC=C4CC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL337212 oxyr_rat Rat No 6.4 IC50 = 390 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
445 4 1 4 4.1 CC(=O)NC1CC2CCC1(C2(C)C)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3
CHEMBL338324 oxyr_rat Rat No 5.4 IC50 = 3900 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
402 3 1 4 4.0 CC1(C2CCC1(C(C2)O)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL339498 oxyr_rat Rat No 8.4 IC50 = 4.1 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
623 10 3 8 2.3 CC1(C2CCC1(C(C2)NC(=O)C(CCS(=O)(=O)C)NC(=O)CN)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL338984 oxyr_rat Rat No 8.4 IC50 = 4.2 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
525 5 0 6 3.6 CC1(C2CCC1(C(C2)N3C(=O)CN(C3=O)CC#N)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL2112896 oxyr_rat Rat No 8.3 IC50 = 4.9 Funct
Displacement of [3H]OT from binding to oxytocin receptor of rat uterusDisplacement of [3H]OT from binding to oxytocin receptor of rat uterus
583 10 1 8 3.1 CC1=CC=CC=C1N2CCN(CC2)S(=O)(=O)CC34CCC(C3(C)C)CC4NC(=O)C(CCS(=O)(=O)C)N(C)C
CHEMBL128749 oxyr_rat Rat No 8.3 IC50 = 4.9 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
594 9 1 7 3.9 CC1(C2CCC1(C(C2)NC(=O)C(CCS(=O)(=O)C)N(C)C)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL393020 oxyr_human Human Yes 7.4 IC50 = 40 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1034 19 10 14 -0.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)N3CCCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL393020 oxyr_human Human Yes 7.4 IC50 = 40 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1034 19 10 14 -0.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)N3CCCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL429971 oxyr_rat Rat No 7.4 IC50 = 40 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
543 7 2 7 2.4 CC1(C2CCC1(C(C2)N3C(=O)CC(C3=O)NCCN)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL2112663 oxyr_rat Rat No 7.4 IC50 = 40 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
582 8 3 8 1.7 CC1(C2CCC1(C(C2)(CNC(=O)C(CS(=O)(=O)C)N)O)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL341490 oxyr_rat Rat No 5.4 IC50 = 4000 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
339 2 0 3 4.2 CC1=CC=C(C=C1)S(=O)(=O)N2CCC3(CC2)C=CC4=CC=CC=C34
CHEMBL2112655 oxyr_rat Rat No 6.4 IC50 = 410 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
708 8 4 7 2.8 CCC(C)C1C(=O)N2CCCCC2C(=O)N3CCCCC3C(=O)NC(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CC=CC=C5)CCCCN
CHEMBL336742 oxyr_rat Rat No 6.4 IC50 = 410 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
503 7 2 6 3.5 CC1(C2CCC1(C(C2)NC(=O)CCC(=O)O)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL3763951 oxyr_human Human No 5.4 IC50 = 4129 Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as inhibition of agonist-induced IP1 accumulation preincubated for 30 mins followed by agonist addition measured after 1 hr by HTRF assayAntagonist activity at human OTR expressed in HEK293 cells assessed as inhibition of agonist-induced IP1 accumulation preincubated for 30 mins followed by agonist addition measured after 1 hr by HTRF assay
610 7 2 7 2.9 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCN(CC5)CC6=CC(=CC(=C6)OC)OC
CHEMBL3763951 oxyr_human Human No 5.4 IC50 = 4129 Funct
Antagonist activity at human oxytocin receptor expressed in HEK293 cells assessed as inhibition of oxytocin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assayAntagonist activity at human oxytocin receptor expressed in HEK293 cells assessed as inhibition of oxytocin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
610 7 2 7 2.9 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCN(CC5)CC6=CC(=CC(=C6)OC)OC
CHEMBL3763951 oxyr_human Human No 5.4 IC50 = 4129 Funct
Antagonist activity at human oxytocin receptor expressed in HEK293 cells assessed as inhibition of oxytocin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assayAntagonist activity at human oxytocin receptor expressed in HEK293 cells assessed as inhibition of oxytocin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
610 7 2 7 2.9 CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCN(CC5)CC6=CC(=CC(=C6)OC)OC
CHEMBL132389 oxyr_rat Rat No 7.4 IC50 = 42 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
544 8 3 6 4.0 CC(C)CC(C(=O)NCC1(CC2CCC1(C2(C)C)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)O)N
CHEMBL338503 oxyr_rat Rat No 7.4 IC50 = 42 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
557 7 1 7 3.6 CC1(C2CCC1(C(C2)N3C(=O)CC(C3=O)CCC(=O)O)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL127445 oxyr_rat Rat No 7.4 IC50 = 43 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
530 7 3 6 3.6 CC(C)C(C(=O)NCC1(CC2CCC1(C2(C)C)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)O)N
CHEMBL280356 oxyr_rat Rat No 7.4 IC50 = 44 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
558 7 2 8 0.7 CC1(C2CCC1(C(C2)N3C(=O)CC(C3=O)NCC(=O)O)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL340204 oxyr_rat Rat No 7.4 IC50 = 45 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
808 10 4 7 5.1 CCC(C)C1C(=O)N2CCCCC2C(=O)NC(C(=O)N(C(C(=O)N3CCCC3C(=O)NC(C(=O)N1)CC4=CC=CC5=CC=CC=C54)CC6=CC=CC=C6)C)CCCCN
CHEMBL128417 oxyr_rat Rat No 7.4 IC50 = 45 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
539 7 3 6 2.9 CC1(C2CCC1(C(C2)(CNC(=O)CC3=CN=CN3)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL2111851 oxyr_rat Rat No 7.4 IC50 = 45 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
566 8 2 7 2.9 CC1(C2CCC1(C(C2)NC(=O)C(CCS(=O)(=O)C)N)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL338499 oxyr_rat Rat No 7.4 IC50 = 45 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
543 8 2 5 5.8 CCC(C)(C)C(=O)NCCC1(CC2CCC1(C2(C)C)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)O
CHEMBL341311 oxyr_rat Rat No 7.4 IC50 = 45 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
540 7 3 6 3.3 CC1(C2CCC1(C(C2)NC(=O)C(CC3=CN=CN3)N)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL337842 oxyr_rat Rat No 6.4 IC50 = 450 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
417 3 1 5 4.0 CC1(C2CCC1(C(=NO)C2)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL339698 oxyr_rat Rat No 5.4 IC50 = 4500 Funct
Compound was evaluated for half-maximal inhibition of binding of [3H]oxytocin to Oxytocin receptor in rat uterine tissueCompound was evaluated for half-maximal inhibition of binding of [3H]oxytocin to Oxytocin receptor in rat uterine tissue
559 3 0 4 4.4 CC1(C2CCC1(C(=O)C2)CS(=O)(=O)N3CCC4(CC3)C(C(C5=CC=CC=C45)Br)Br)C
CHEMBL339124 oxyr_rat Rat No 7.3 IC50 = 46 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
513 7 2 6 3.3 CC1(C2CCC1(C(C2)NC(=O)C(CCC#N)N)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL340153 oxyr_rat Rat No 6.3 IC50 = 460 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
478 4 1 4 5.3 CC1(C2CCC1(C(C2)(C3=CC=CC=C3)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL340150 oxyr_rat Rat No 6.3 IC50 = 460 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
446 4 2 4 3.5 CC1(C2CCC1(C(C2)NC(=O)N)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL338318 oxyr_rat Rat No 6.3 IC50 = 470 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
402 3 1 4 4.0 CC1(C2CCC1(C(C2)O)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL334953 oxyr_rat Rat No 6.3 IC50 = 470 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
402 3 1 4 4.0 CC1(C2CCC1(C(C2)O)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL128163 oxyr_rat Rat No 7.3 IC50 = 48 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
544 6 1 7 3.5 CC1(C2CCC1(C(C2)N3C(=O)CN(C3=O)CC(=O)O)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL341338 oxyr_rat Rat No 7.3 IC50 = 48 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
525 6 1 5 3.8 CC1(C2CCC1(C(C2)NC(=O)CC3=CN=CN3C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL339464 oxyr_rat Rat No 6.3 IC50 = 480 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
607 7 2 5 6.6 CC1(C2CCC1(C(C2)(CNC(=O)CC34CC5CC(C3)CC(C5)C4)O)CS(=O)(=O)N6CCC7(CC6)C=CC8=CC=CC=C78)C
CHEMBL393021 oxyr_human Human Yes 6.3 IC50 = 485 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1008 20 11 14 -1.2 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)NC(C)(C)C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL393021 oxyr_human Human Yes 6.3 IC50 = 485 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1008 20 11 14 -1.2 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)NC(C)(C)C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL2113177 oxyr_human Human No 7.3 IC50 = 49 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
597 11 3 9 3.9 C1COCCN1CCNC2=CC=C(C=C2)S(=O)(=O)N(CC(=O)NNC3=C4C=CC=CC4=NC3=O)C5=CC=C(C=C5)Cl
CHEMBL449399 oxyr_rat Rat No 7.3 IC50 = 49 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
568 6 1 8 2.9 CC1(C2CCC1(C(C2)N3C(=O)CN(C3=O)CC4=NNN=N4)CS(=O)(=O)N5CCC6(CCC7=CC=CC=C76)CC5)C
CHEMBL130993 oxyr_rat Rat No 7.3 IC50 = 49 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
566 7 2 6 3.8 CC1(C2CCC1(C(C2)(CCNC(=O)C3=CCC(=O)N=C3)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL419973 oxyr_rat Rat No 7.3 IC50 = 49 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
568 8 2 6 4.3 CC1(C2CCC1(C(C2)NC(=O)C(CC3=CN=CN3)N(C)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL2113177 oxyr_human Human No 7.3 IC50 = 49 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
597 11 3 9 3.9 C1COCCN1CCNC2=CC=C(C=C2)S(=O)(=O)N(CC(=O)NNC3=C4C=CC=CC4=NC3=O)C5=CC=C(C=C5)Cl
CHEMBL284120 oxyr_human Human No 8.3 IC50 = 5 Funct
Inhibitory concentration required for antagonist activity against oxytocin receptorInhibitory concentration required for antagonist activity against oxytocin receptor
637 12 3 6 3.5 CC(=O)CCCC(=O)NC1C(=O)N(C2=CC=CC=C2C(=N1)C3=CC=CC=C3)CC(=O)NC(CC4=CC(=C(C=C4)Cl)Cl)C(=O)N
CHEMBL339768 oxyr_rat Rat No 8.2 IC50 = 5.9 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
609 7 2 7 3.2 CC1(C2CCC1(C(C2)N3C(=O)CN(C3=O)CC(=O)NC4=NC=CN4)CS(=O)(=O)N5CCC6(CCC7=CC=CC=C76)CC5)C
CHEMBL338548 oxyr_rat Rat No 7.3 IC50 = 50 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
544 6 2 7 3.2 CC1(C2CCC1(C(C2)N3C(=O)C(NC3=O)CC(=O)O)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL337853 oxyr_rat Rat No 7.3 IC50 = 50 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
541 6 4 8 2.9 CC1(C2CCC1(C(C2)(CNC(=O)C3=NC(=NN3)N)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL339433 oxyr_rat Rat No 7.3 IC50 = 50 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
514 5 2 6 2.8 CC1(C2CCC1(C(C2)(CN3C(=O)CNC3=O)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL340676 oxyr_rat Rat No 7.3 IC50 = 50 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
639 11 4 7 2.0 CC1(C2CCC1(C(C2)NC(=O)CC(CC(=O)N)NC(=O)CC3=CN=CN3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL115277 oxyr_rat Rat No 5.3 IC50 = 5000 Funct
Compound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissueCompound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissue
456 8 0 8 4.4 CC1=CC(=C2C(=C1)COC(=O)C3=C(O2)C=CC(=C3OC)C(CC(C)C)OC(=O)C)OC(=O)C
CHEMBL115277 oxyr_rat Rat No 5.3 IC50 = 5000 Funct
Compound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissueCompound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissue
456 8 0 8 4.4 CC1=CC(=C2C(=C1)COC(=O)C3=C(O2)C=CC(=C3OC)C(CC(C)C)OC(=O)C)OC(=O)C
CHEMBL341077 oxyr_rat Rat No 5.3 IC50 = 5000 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
303 2 0 1 4.1 C1CN(CCC12C=CC3=CC=CC=C23)C(=O)CC4=CC=CC=C4
CHEMBL415417 oxyr_human Human No 4.3 IC50 = 51700 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1023 18 13 15 -1.5 CC(C)CC(C(=O)NCC(=O)N)NC(=O)C(C(C)(C)C)NC(=O)C1CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CCC(=O)N)C(C)(C)C)CC2=CC=C(C=C2)O)N
CHEMBL415417 oxyr_human Human No 4.3 IC50 = 51700 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1023 18 13 15 -1.5 CC(C)CC(C(=O)NCC(=O)N)NC(=O)C(C(C)(C)C)NC(=O)C1CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CCC(=O)N)C(C)(C)C)CC2=CC=C(C=C2)O)N
CHEMBL49429 oxyr_human Human Yes 6.3 IC50 = 519 Funct
Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsDisplacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cells
474 3 1 3 4.8 CC1=C(C=C(C=C1)F)C(=O)NC2=CC(=C(C=C2)C(=O)N3CC4=CC=CN4CC5=CC=CC=C53)Cl
CHEMBL49429 oxyr_human Human Yes 6.3 IC50 = 519 Funct
Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsDisplacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cells
474 3 1 3 4.8 CC1=C(C=C(C=C1)F)C(=O)NC2=CC(=C(C=C2)C(=O)N3CC4=CC=CN4CC5=CC=CC=C53)Cl
CHEMBL20230 oxyr_rat Rat No 7.3 IC50 = 52 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
511 6 2 5 3.8 CC1(C2CCC1(C(C2)NC(=O)CC3=CN=CN3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL338522 oxyr_rat Rat Yes 7.3 IC50 = 52 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
511 6 2 5 3.8 CC1(C2CCC1(C(C2)NC(=O)CC3=CN=CN3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL131551 oxyr_rat Rat No 7.3 IC50 = 53 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
550 7 2 6 3.7 CC1(C2CCC1(C(C2)(CNC(=O)CC3=CN=CC=C3)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL336857 oxyr_rat Rat No 6.3 IC50 = 530 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
535 7 1 4 6.0 CC1(C2CCC1(C(C2)NC(=O)CCC3=CC=CC=C3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL340915 oxyr_rat Rat No 7.3 IC50 = 54 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
550 8 2 7 2.7 CC1(C2CCC1(C(C2)NC(=O)C(CCS(=O)C)N)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL127056 oxyr_rat Rat No 6.3 IC50 = 540 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
727 6 2 6 4.4 CCC(C)C1C(=O)N2CCCC2C(=O)N3CCCCC3C(=O)N(C(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CC=CC=C5)CC6=CC=CC=C6)C
CHEMBL434825 oxyr_rat Rat No 5.3 IC50 = 5400 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
402 6 0 5 4.1 CCOC(=O)C1(CCN(CC1C)S(=O)(=O)C2=CC=C(C=C2)C)C3=CC=CC=C3
CHEMBL363910 oxyr_rat Rat Yes 7.3 IC50 = 55 Funct
Antagonist activity at OXR receptor in rat uterusAntagonist activity at OXR receptor in rat uterus
403 2 0 2 3.9 CC1=NN(C=C1)C2=CC(=C(C=C2)C(=O)N3CC4=CC=CN4CC5=CC=CC=C53)Cl
CHEMBL233080 oxyr_human Human Yes 7.3 IC50 = 55 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1062 19 10 14 -0.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)NC(C)(C)C(=O)NC(CC(C)C)C(=O)N3CCCCC3C(=O)N)CC(=O)N)CCC(=O)N
CHEMBL233080 oxyr_human Human Yes 7.3 IC50 = 55 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1062 19 10 14 -0.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)NC(C)(C)C(=O)NC(CC(C)C)C(=O)N3CCCCC3C(=O)N)CC(=O)N)CCC(=O)N
CHEMBL131650 oxyr_rat Rat No 7.3 IC50 = 55 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
531 8 3 6 2.4 CC1(C2CCC1(C(C2)NC(=O)C(CCC(=O)N)N)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL339302 oxyr_rat Rat No 6.3 IC50 = 560 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
420 3 1 5 4.1 CC1(C2CCC1(C(C2)O)CS(=O)(=O)N3CCC4(CC3)C=CC5=C4C=C(C=C5)F)C
CHEMBL127016 oxyr_rat Rat No 6.3 IC50 = 560 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
420 3 1 5 4.1 CC1(C2CCC1(C(C2)O)CS(=O)(=O)N3CCC4(CC3)C=CC5=C4C=CC(=C5)F)C
CHEMBL338118 oxyr_rat Rat No 7.2 IC50 = 57 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
568 6 2 6 3.7 CC1(C2CCC1(C(C2)(CNC(=O)C3CN4CCC3CC4)O)CS(=O)(=O)N5CCC6(CC5)C=CC7=CC=CC=C67)C
CHEMBL338490 oxyr_rat Rat No 6.2 IC50 = 570 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
549 8 1 4 6.3 CC1(C2CCC1(C(C2)NC(=O)CCCC3=CC=CC=C3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL127117 oxyr_rat Rat No 5.2 IC50 = 5700 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
341 2 0 3 4.3 CC1=CC=C(C=C1)S(=O)(=O)N2CCC3(CCC4=CC=CC=C43)CC2
CHEMBL339366 oxyr_rat Rat No 6.2 IC50 = 580 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
516 7 2 5 4.9 CC(C)CC(C(=O)NC1CC2CCC1(C2(C)C)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)N
CHEMBL2113203 oxyr_human Human No 7.2 IC50 = 59 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
556 11 2 8 4.2 CN(C)CCOC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NNC2=C3C=CC=CC3=NC2=O)C4=CC=C(C=C4)Cl
CHEMBL382301 oxyr_human Human Yes 7.2 IC50 = 59 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
994 18 11 15 -1.9 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)N3CCCC3C(=O)NC(CCCN)C(=O)NCC(=O)N)CC(=O)N)C(C)O
CHEMBL2113203 oxyr_human Human No 7.2 IC50 = 59 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
556 11 2 8 4.2 CN(C)CCOC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NNC2=C3C=CC=CC3=NC2=O)C4=CC=C(C=C4)Cl
CHEMBL382301 oxyr_human Human Yes 7.2 IC50 = 59 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
994 18 11 15 -1.9 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)N3CCCC3C(=O)NC(CCCN)C(=O)NCC(=O)N)CC(=O)N)C(C)O
CHEMBL125847 oxyr_rat Rat No 6.2 IC50 = 590 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
416 3 1 4 4.5 CC1C2CCC(C1O)(C2(C)C)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45
CHEMBL2112248 oxyr_rat Rat No 8.2 IC50 = 6 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
755 6 5 8 1.9 CCC(C)C1C(=O)N2C(CCC=N2)C(=O)N3CCCCC3C(=O)NC(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CNC6=CC=CC=C65)CC7=CN=CN7
CHEMBL339756 oxyr_rat Rat No 8.2 IC50 = 6 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
631 9 0 7 3.4 CC1(C2CCC1(C(C2)N(CCS(=O)(=O)C)C(=O)CC3=CN(C=N3)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL128219 oxyr_rat Rat No 8.2 IC50 = 6.3 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
602 11 4 7 1.7 CC1(C2CCC1(C(C2)NC(=O)C(CCC(=O)N)NC(=O)CCN)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL339524 oxyr_rat Rat No 8.2 IC50 = 6.7 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
597 7 4 9 3.4 CC1(C2CCC1(C(C2)N3C(=O)C(NC3=O)CNC4=NNC(=N4)N)CS(=O)(=O)N5CCC6(CCC7=CC=CC=C76)CC5)C
CHEMBL129971 oxyr_rat Rat No 7.2 IC50 = 60 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
539 6 1 5 4.4 CC(C1=CN(C=N1)C)C(=O)NC2CC3CCC2(C3(C)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4
CHEMBL336195 oxyr_rat Rat No 7.2 IC50 = 60 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
486 4 1 5 3.5 CC1(C2CCC1(C(C2)N3CCC(C3=O)N)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL594828 oxyr_human Human Yes 6.2 IC50 = 600 Funct
Antagonist activity at human OTR receptor expressed in HEK293FT cells assessed as inhibition of LIT-001-induced calcium release by Aequorin based assayAntagonist activity at human OTR receptor expressed in HEK293FT cells assessed as inhibition of LIT-001-induced calcium release by Aequorin based assay
420 7 0 8 2.7 COCC1=NN=C(N1C2=CN=C(C=C2)OC)N3CC(C3)OC4=C(C=C(C=C4)F)Cl
CHEMBL129104 oxyr_rat Rat No 6.2 IC50 = 600 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
416 3 1 4 4.2 CC1(C2CCC1(C(C2)(C)O)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL126195 oxyr_rat Rat Yes 5.2 IC50 = 6000 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
355 3 0 4 3.8 COC1=CC=C(C=C1)S(=O)(=O)N2CCC3(CC2)C=CC4=CC=CC=C34
CHEMBL128228 oxyr_rat Rat No 7.2 IC50 = 61 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
543 6 2 6 2.9 CC1(C2CCC1(C(C2)NC(=O)CN3CCC(C3=O)N)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL132211 oxyr_rat Rat No 7.2 IC50 = 61 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
545 8 2 6 3.5 CC1(C2CCC1(C(C2)NC(=O)CNC(=O)CN(C)C)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL339783 oxyr_rat Rat No 6.2 IC50 = 620 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
513 5 1 5 5.8 CC1(C2CCC1(C(C2)NC(=O)C3=CC=CS3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL129581 oxyr_rat Rat No 5.2 IC50 = 6200 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
414 3 0 4 4.1 CC1=CC=CC2=C1C=CC23CCN(CC3)S(=O)(=O)CC45CCC(C4(C)C)CC5=O
CHEMBL126824 oxyr_rat Rat No 5.2 IC50 = 6200 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
414 3 0 4 4.1 CC1=CC=CC2=C1C3(CCN(CC3)S(=O)(=O)CC45CCC(C4(C)C)CC5=O)C=C2
CHEMBL594828 oxyr_human Human Yes 7.2 IC50 = 63 Funct
Antagonist activity at human OTR receptor expressed in HEK293FT cells assessed as inhibition of LIT-001-induced response incubated for 30 mins by beta-arrestin recruitment assayAntagonist activity at human OTR receptor expressed in HEK293FT cells assessed as inhibition of LIT-001-induced response incubated for 30 mins by beta-arrestin recruitment assay
420 7 0 8 2.7 COCC1=NN=C(N1C2=CN=C(C=C2)OC)N3CC(C3)OC4=C(C=C(C=C4)F)Cl
CHEMBL338235 oxyr_rat Rat No 6.2 IC50 = 630 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
430 4 1 4 4.7 CCC1(CC2CCC1(C2(C)C)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)O
CHEMBL279022 oxyr_rat Rat No 7.2 IC50 = 64 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
590 7 1 6 4.9 CC1(C2CCC1(C(C2)N3C(=O)CC(C3=O)NCC4=CC=CC=C4)CS(=O)(=O)N5CCC6(CCC7=CC=CC=C76)CC5)C
CHEMBL24781 oxyr_rat Rat Yes 6.2 IC50 = 640 Funct
Compound was tested for displacement of 3[H] oxytocin from rat OT receptor (in vitro)Compound was tested for displacement of 3[H] oxytocin from rat OT receptor (in vitro)
508 5 0 6 3.0 CC(=O)N1CCC(CC1)OC2=CC(=C(C=C2)C(=O)N3CCC(CC3)N4C5=CC=CC=C5COC4=O)OC
CHEMBL129246 oxyr_rat Rat No 5.2 IC50 = 6400 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
359 3 0 4 3.0 C1CCC(=O)C(C1)CS(=O)(=O)N2CCC3(CC2)C=CC4=CC=CC=C34
CHEMBL419793 oxyr_rat Rat No 7.2 IC50 = 65 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
797 10 5 7 4.0 CCC(C)C1C(=O)N2CCCCC2C(=O)NC(C(=O)N(C(C(=O)N3CCCC3C(=O)NC(C(=O)N1)CC4=CNC5=CC=CC=C54)CC6=CC=CC=C6)C)CCCCN
CHEMBL132496 oxyr_rat Rat No 7.2 IC50 = 65 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
525 6 1 5 3.8 CC1(C2CCC1(C(C2)NC(=O)CC3=CN(C=N3)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL341470 oxyr_rat Rat No 6.2 IC50 = 650 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
415 3 1 5 4.0 CC1(C2CCC1(C(=NO)C2)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL435398 oxyr_rat Rat No 6.2 IC50 = 650 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
513 5 1 4 6.2 CC1(C2CCC1(C(C2)NC(=O)C3CCCCC3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL340465 oxyr_rat Rat No 5.2 IC50 = 6500 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
431 3 0 5 2.0 CC1(C2CCC1(C(=O)C2)CS(=O)(=O)N3CCC4(CC3)C5=CC=CC=C5N(C4=O)C)C
CHEMBL129955 oxyr_rat Rat No 5.2 IC50 = 6500 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
403 3 1 4 3.8 CC1(C2CCC1(C(C2)N)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL129089 oxyr_rat Rat No 6.2 IC50 = 660 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
755 6 2 6 5.1 CCC(C)C1C(=O)N2CCCCC2C(=O)N3CCCCC3C(=O)N(C(C(=O)N4CCCCC4C(=O)NC(C(=O)N1)CC5=CC=CC=C5)CC6=CC=CC=C6)C
CHEMBL338981 oxyr_rat Rat No 6.2 IC50 = 670 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
727 6 2 6 4.4 CCC(C)C1C(=O)N2CCCCC2C(=O)N3CCCC3C(=O)N(C(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CC=CC=C5)CC6=CC=CC=C6)C
CHEMBL325752 oxyr_rat Rat Yes 4.2 IC50 = 67000 Funct
Compound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissueCompound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissue
372 4 2 6 3.7 CC1=CC(=C2C(=C1)COC(=O)C3=C(O2)C=CC(=C3OC)C(CC(C)C)O)O
CHEMBL325752 oxyr_rat Rat Yes 4.2 IC50 = 67000 Funct
Compound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissueCompound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissue
372 4 2 6 3.7 CC1=CC(=C2C(=C1)COC(=O)C3=C(O2)C=CC(=C3OC)C(CC(C)C)O)O
CHEMBL277400 oxyr_human Human No 7.2 IC50 = 68 Funct
Antagonistic activity against Oxytocin receptorAntagonistic activity against Oxytocin receptor
514 5 2 5 4.1 CC1(C2CCC1(C(C2)NC(=O)C3CCCNC3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL421248 oxyr_rat Rat No 7.2 IC50 = 68 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
540 7 3 5 4.0 CC1(C2CCC1(C(C2)NC(=O)NCCC3=CN=CN3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL395290 oxyr_human Human Yes 8.2 IC50 = 7 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1021 17 12 15 -2.2 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL2113208 oxyr_human Human No 8.2 IC50 = 7 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
587 14 2 9 3.9 COCCOCCOC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NNC2=C3C=CC=CC3=NC2=O)C4=CC=C(C=C4)Cl
CHEMBL2113185 oxyr_human Human No 8.2 IC50 = 7 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
598 11 2 9 3.9 C1COCCN1CCOC2=CC=C(C=C2)S(=O)(=O)N(CC(=O)NNC3=C4C=CC=CC4=NC3=O)C5=CC=C(C=C5)Cl
CHEMBL395290 oxyr_human Human Yes 8.2 IC50 = 7 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1021 17 12 15 -2.2 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL19658 oxyr_rat Rat No 8.2 IC50 = 7 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
500 4 1 6 2.9 CC1(C2CCC1(C(C2)N3C(=O)CC(C3=O)N)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL2113208 oxyr_human Human No 8.2 IC50 = 7 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
587 14 2 9 3.9 COCCOCCOC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NNC2=C3C=CC=CC3=NC2=O)C4=CC=C(C=C4)Cl
CHEMBL2113185 oxyr_human Human No 8.2 IC50 = 7 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
598 11 2 9 3.9 C1COCCN1CCOC2=CC=C(C=C2)S(=O)(=O)N(CC(=O)NNC3=C4C=CC=CC4=NC3=O)C5=CC=C(C=C5)Cl
CHEMBL436189 oxyr_rat Rat No 8.1 IC50 = 7.6 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
702 12 4 9 2.0 CC1(C2CCC1(C(C2)(CNC(=O)C(CCS(=O)(=O)C)NC(=O)CC3=CN=CN3)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL341108 oxyr_rat Rat No 5.2 IC50 = 7100 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
343 2 0 4 3.9 C1CN(CCC12C=CC3=CC=CC=C23)S(=O)(=O)C4=CC=C(C=C4)F
CHEMBL405289 oxyr_rat Rat No 7.1 IC50 = 72 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
756 7 5 7 3.0 CCCCC1C(=O)N2CCCCC2C(=O)N3CCCCC3C(=O)NC(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CNC6=CC=CC=C65)CC7=CN=CN7
CHEMBL435159 oxyr_human Human Yes 6.1 IC50 = 730 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1069 17 12 15 -1.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CC4=CC=CC=C4CC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL435159 oxyr_human Human Yes 6.1 IC50 = 730 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1069 17 12 15 -1.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CC4=CC=CC=C4CC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL284442 oxyr_rat Rat No 6.1 IC50 = 744 Funct
Compound was tested for displacement of 3[H] oxytocin from rat OT receptor (in vitro)Compound was tested for displacement of 3[H] oxytocin from rat OT receptor (in vitro)
610 6 1 10 2.4 C1CN(CCC1N2C3=CC=CC=C3COC2=O)C(=O)C4=CN=C5C(=C4)C=C(O5)CNC(=O)CN6C=C(C=CC6=O)C(F)(F)F
CHEMBL395430 oxyr_human Human Yes 7.1 IC50 = 75 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
995 18 13 15 -2.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)NC(C)(C)C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL395430 oxyr_human Human Yes 7.1 IC50 = 75 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
995 18 13 15 -2.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)NC(C)(C)C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL129513 oxyr_rat Rat No 6.1 IC50 = 760 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
364 2 0 2 3.9 CC1(C2CCC1(C(=O)C2)CC(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL340588 oxyr_rat Rat No 5.1 IC50 = 7600 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
434 3 0 4 4.3 CC1(C2CCC1(C(=O)C2)CS(=O)(=O)N3CCC4(CC3)C=CC5=C4C=C(C=C5)Cl)C
CHEMBL128978 oxyr_rat Rat No 5.1 IC50 = 7600 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
434 3 0 4 4.3 CC1(C2CCC1(C(=O)C2)CS(=O)(=O)N3CCC4(CC3)C=CC5=C4C=CC(=C5)Cl)C
CHEMBL127049 oxyr_rat Rat No 6.1 IC50 = 770 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
441 4 1 5 4.1 CC1(C2CCC1(C(C2)(CC#N)O)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL131499 oxyr_rat Rat No 6.1 IC50 = 770 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
441 4 1 5 4.1 CC1(C2CCC1(C(C2)(CC#N)O)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL339681 oxyr_rat Rat No 6.1 IC50 = 780 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
460 5 2 6 3.9 CC1(C2CCC1(C(C2)(CC(=O)O)O)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL337615 oxyr_rat Rat No 7.1 IC50 = 79 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
550 7 2 6 4.7 CC1(C2CCC1(C(C2)(CCNC(=O)C3=CC=NC=C3)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL2113211 oxyr_human Human No 8.1 IC50 = 8 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
543 11 2 8 4.0 COCCOC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NNC2=C3C=CC=CC3=NC2=O)C4=CC=C(C=C4)Cl
CHEMBL2369136 oxyr_human Human No 8.1 IC50 = 8 Funct
Binding affinity towards oxytocin receptorBinding affinity towards oxytocin receptor
1089 10 11 15 -1.0 CCC(C)C1C(=O)NC2CCC(=O)NCCCCC(NC(=O)C3CCCN3C(=O)C(CSSC(C(C(=O)NC(C(=O)N1)C(C)C4=C(C=C(C=C4C)OC)C)N)(C)C)NC(=O)C(NC2=O)CC(=O)N)C(=O)NCC(=O)N
CHEMBL2113211 oxyr_human Human No 8.1 IC50 = 8 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
543 11 2 8 4.0 COCCOC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NNC2=C3C=CC=CC3=NC2=O)C4=CC=C(C=C4)Cl
CHEMBL2112250 oxyr_rat Rat No 8.1 IC50 = 8.3 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
767 6 4 7 4.0 CCC(C)C1C(=O)N2CCCCC2C(=O)N3CCCCC3C(=O)NC(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CC=CC6=CC=CC=C65)CC7=CN=CN7
CHEMBL337889 oxyr_rat Rat No 8.1 IC50 = 8.3 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
638 10 4 7 3.6 CC(C)C(C(=O)NCC1(CC2CCC1(C2(C)C)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)O)NC(=O)CC6=CN=CN6
CHEMBL435021 oxyr_rat Rat No 8.1 IC50 = 8.4 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
781 6 4 7 3.4 CCC(C)C1C(=O)N2CCCCC2C(=O)N3CCNCC3C(=O)N(C(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CNC6=CC=CC=C65)CC7=CC=CC=C7)C
CHEMBL2112903 oxyr_rat Rat No 8.1 IC50 = 8.9 Funct
Displacement of [3H]OT from binding to oxytocin receptor of rat uterusDisplacement of [3H]OT from binding to oxytocin receptor of rat uterus
555 9 2 8 2.1 CC1=CC=CC=C1N2CCN(CC2)S(=O)(=O)CC34CCC(C3(C)C)CC4NC(=O)C(CCS(=O)(=O)C)N
CHEMBL1253853 oxyr_rat Rat Yes 8.1 IC50 = 8.9 Funct
Inhibition of rat uterus OT receptorInhibition of rat uterus OT receptor
555 9 2 8 2.1 CC1=CC=CC=C1N2CCN(CC2)S(=O)(=O)CC34CCC(C3(C)C)CC4NC(=O)C(CCS(=O)(=O)C)N
CHEMBL438849 oxyr_human Human Yes 7.1 IC50 = 80 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1110 19 10 14 0.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)N3CC4=CC=CC=C4CC3C(=O)NC(CC(C)C)C(=O)NC(C)(C)C(=O)N)CC(=O)N)CCC(=O)N
CHEMBL438849 oxyr_human Human Yes 7.1 IC50 = 80 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1110 19 10 14 0.6 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)N3CC4=CC=CC=C4CC3C(=O)NC(CC(C)C)C(=O)NC(C)(C)C(=O)N)CC(=O)N)CCC(=O)N
CHEMBL132165 oxyr_rat Rat No 7.1 IC50 = 80 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
518 8 3 6 3.2 CC1(C2CCC1(C(C2)NC(=O)C(CCCO)N)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL341339 oxyr_rat Rat No 6.1 IC50 = 800 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
460 5 2 6 3.9 CC1(C2CCC1(C(C2)(CC(=O)O)O)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL128423 oxyr_rat Rat No 7.1 IC50 = 81 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
550 7 2 6 3.7 CC1(C2CCC1(C(C2)(CNC(=O)CC3=CC=CC=N3)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL128879 oxyr_rat Rat No 6.1 IC50 = 830 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
511 6 2 5 3.8 CC1(C2CCC1(C(C2)NC(=O)CC3=CN=CN3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL2113200 oxyr_human Human No 6.1 IC50 = 840 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
571 12 2 9 3.2 CN(C)CCCOC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NNC2=C3C=NC=CC3=NC2=O)C4=CC=C(C=C4)Cl
CHEMBL2113200 oxyr_human Human No 6.1 IC50 = 840 Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
571 12 2 9 3.2 CN(C)CCCOC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NNC2=C3C=NC=CC3=NC2=O)C4=CC=C(C=C4)Cl
CHEMBL116226 oxyr_rat Rat No 5.1 IC50 = 8400 Funct
Compound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissueCompound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissue
414 6 1 7 4.3 CC1=CC(=C2C(=C1)COC(=O)C3=C(O2)C=CC(=C3OC)C(CC(C)C)OC(=O)C)O
CHEMBL394268 oxyr_human Human Yes 5.1 IC50 = 8500 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
976 16 10 13 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)N2CC3=CC=CC=C3CC2C(=O)N1)C(=O)NC(C)(C)C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL394268 oxyr_human Human Yes 5.1 IC50 = 8500 Funct
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
976 16 10 13 -1.8 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)N2CC3=CC=CC=C3CC2C(=O)N1)C(=O)NC(C)(C)C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL126708 oxyr_rat Rat No 5.1 IC50 = 8500 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
476 4 0 4 5.1 CC1(C2CCC1(C(=O)C2)CS(=O)(=O)N3CCC4(C=CC5=CC=CC=C54)C(C3)C6=CC=CC=C6)C
CHEMBL2111847 oxyr_rat Rat No 5.1 IC50 = 8700 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
364 2 0 2 3.9 CC1(C2CCC1(C(=O)C2)CC(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL2112654 oxyr_rat Rat No 7.1 IC50 = 88 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
717 6 4 7 2.8 CCC(C)C1C(=O)N2CCCCC2C(=O)N3CCCCC3C(=O)NC(C(=O)N4CCCC4C(=O)NC(C(=O)N1)CC5=CC=CC=C5)CC6=CN=CN6
CHEMBL338409 oxyr_rat Rat No 6.1 IC50 = 890 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
502 7 1 6 5.2 CCOC(=O)C(C)C1(CC2CCC1(C2(C)C)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)O
CHEMBL283126 oxyr_rat Rat No 8.1 IC50 = 9 Funct
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
544 7 2 7 2.7 CC1(C2CCC1(C(C2)N3C(=O)CC(C3=O)NCCO)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL2112898 oxyr_rat Rat No 8.0 IC50 = 9.2 Funct
Displacement of [3H]OT from binding to oxytocin receptor of rat uterusDisplacement of [3H]OT from binding to oxytocin receptor of rat uterus
569 10 2 8 2.6 CC1=CC=CC=C1N2CCN(CC2)S(=O)(=O)CC34CCC(C3(C)C)CC4NC(=O)C(CCS(=O)(=O)C)NC
CHEMBL2391300 oxyr_rat Rat No 8.0 IC50 = 9.2 Funct
Inhibition of rat uterus OT receptorInhibition of rat uterus OT receptor
569 10 2 8 2.6 CC1=CC=CC=C1N2CCN(CC2)S(=O)(=O)CC34CCC(C3(C)C)CC4NC(=O)C(CCS(=O)(=O)C)NC
CHEMBL422612 oxyr_rat Rat No 7.1 IC50 = 90 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
553 8 3 6 3.8 CC1(C2CCC1(C(C2)(CCNC(=O)CC3=CN=CN3)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL131538 oxyr_rat Rat No 7.1 IC50 = 90 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
502 7 2 6 2.4 CC1(C2CCC1(C(C2)C(=O)C(CC(=O)N)N)CS(=O)(=O)N3CCC4(CCC5=CC=CC=C54)CC3)C
CHEMBL130848 oxyr_rat Rat No 7.1 IC50 = 90 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
559 9 4 7 1.5 CC1(C2CCC1(C(C2)(CNC(=O)C(CCC(=O)N)N)O)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45)C
CHEMBL128489 oxyr_rat Rat No 7.0 IC50 = 92 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
542 6 1 5 5.4 CC(C)CC1C(=O)N(C(=O)N1)C2CC3CCC2(C3(C)C)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4
CHEMBL335876 oxyr_rat Rat No 7.0 IC50 = 92 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
515 5 3 5 3.1 CC1(C2CCC1(C(C2)NC(=O)C3CNC(=O)N3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL2112650 oxyr_rat Rat No 6.0 IC50 = 930 Funct
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
729 6 2 6 4.7 CCC(C)C1C(=O)N2CCCCC2C(=O)N3CCCCC3C(=O)N(C(C(=O)N(C(C(=O)NC(C(=O)N1)CC4=CC=CC=C4)C)C)CC5=CC=CC=C5)C
CHEMBL128422 oxyr_rat Rat No 7.0 IC50 = 94 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
525 7 2 5 4.1 CC1(C2CCC1(C(C2)NC(=O)CCC3=CN=CN3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL335634 oxyr_rat Rat No 7.0 IC50 = 95 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
522 6 1 5 4.6 CC1(C2CCC1(C(C2)NC(=O)CC3=CC=CC=N3)CS(=O)(=O)N4CCC5(CCC6=CC=CC=C65)CC4)C
CHEMBL340964 oxyr_rat Rat No 7.0 IC50 = 97 Funct
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
550 7 2 6 4.7 CC1(C2CCC1(C(C2)(CCNC(=O)C3=CN=CC=C3)O)CS(=O)(=O)N4CCC5(CC4)C=CC6=CC=CC=C56)C
CHEMBL340237 oxyr_rat Rat No 6.0 IC50 = 980 Funct
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
416 3 1 4 4.5 CC1C2CCC(C1O)(C2(C)C)CS(=O)(=O)N3CCC4(CC3)C=CC5=CC=CC=C45
CHEMBL3142545 oxyr_human Human No 9.6 Kd = 0.3 Funct
Dissociation constant value for human OT-receptorDissociation constant value for human OT-receptor
1376 36 13 18 1.7 CCC(C)C(C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(CS)C(=O)N1CCCC1C(=O)NC(CCCN)C(=O)NC(CC2=CC(=C(C=C2)N=[N+]=[N-])I)C(=O)N)NC(=O)C(CC3=CC=C(C=C3)OC)NC(=O)CC4(CCCCC4)SCCC(=O)N
CHEMBL3142790 oxyr_human Human No 9.6 Kd = 0.3 Funct
Dissociation constant value for human OT-receptorDissociation constant value for human OT-receptor
1378 36 13 18 1.7 CCC(C)C(C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(CS)C(=O)N1CCCC1C(=O)NC(CCCN)C(=O)NC(CC2=CC(=C(C=C2)N=[N+]=[N-])I)C(=O)N)NC(=O)C(CC3=CC=C(C=C3)OC)NC(=O)CC4(CCCCC4)SCCC(=O)N
CHEMBL2112896 oxyr_rat Rat No 9.0 Kd = 1 Funct
In vitro antagonism of OT-induced uterine contractions, against rat uterus by measuring pA2 valueIn vitro antagonism of OT-induced uterine contractions, against rat uterus by measuring pA2 value
583 10 1 8 3.1 CC1=CC=CC=C1N2CCN(CC2)S(=O)(=O)CC34CCC(C3(C)C)CC4NC(=O)C(CCS(=O)(=O)C)N(C)C
CHEMBL2112903 oxyr_rat Rat No 8.9 Kd = 1.3 Funct
In vitro antagonism of OT-induced uterine contractions, against rat uterus by measuring pA2 value which refers to the negative logarithm of the molar concentrationIn vitro antagonism of OT-induced uterine contractions, against rat uterus by measuring pA2 value which refers to the negative logarithm of the molar concentration
555 9 2 8 2.1 CC1=CC=CC=C1N2CCN(CC2)S(=O)(=O)CC34CCC(C3(C)C)CC4NC(=O)C(CCS(=O)(=O)C)N
CHEMBL3416750 oxyr_human Human No 8.9 Kd = 1.4 Funct
Binding affinity to SNAP-tagged oxytocin receptor (unknown origin) expressed in HEK293 cells by TR-FRET assayBinding affinity to SNAP-tagged oxytocin receptor (unknown origin) expressed in HEK293 cells by TR-FRET assay
1208 23 5 15 7.3 CCN1C2=C(C=C(C=C2)S(=O)(=O)O)C(C1=CC=CC=CC3=[N+](C4=C(C3(C)C)C=CC(=C4)S(=O)(=O)[O-])CC)(C)CCCC(=O)NCCNC(=O)CCC5=CC=C(C=C5)S(=O)(=O)N(CC(=O)NNC6=C7C=CC=CC7=NC6=O)C8=CC=C(C=C8)Cl
CHEMBL3416750 oxyr_human Human No 8.9 Kd = 1.4 Funct
Binding affinity to SNAP-tagged oxytocin receptor (unknown origin) expressed in HEK293 cells by TR-FRET assayBinding affinity to SNAP-tagged oxytocin receptor (unknown origin) expressed in HEK293 cells by TR-FRET assay
1208 23 5 15 7.3 CCN1C2=C(C=C(C=C2)S(=O)(=O)O)C(C1=CC=CC=CC3=[N+](C4=C(C3(C)C)C=CC(=C4)S(=O)(=O)[O-])CC)(C)CCCC(=O)NCCNC(=O)CCC5=CC=C(C=C5)S(=O)(=O)N(CC(=O)NNC6=C7C=CC=CC7=NC6=O)C8=CC=C(C=C8)Cl
CHEMBL3416749 oxyr_human Human No 8.8 Kd = 1.7 Funct
Binding affinity to SNAP-tagged oxytocin receptor (unknown origin) expressed in HEK293 cells by TR-FRET assayBinding affinity to SNAP-tagged oxytocin receptor (unknown origin) expressed in HEK293 cells by TR-FRET assay
1055 22 7 14 5.5 C1=CC2=C(C(=O)N=C2C=C1)NNC(=O)CN(C3=CC=C(C=C3)Cl)S(=O)(=O)C4=CC=C(C=C4)CCC(=O)NCCNC(=O)CCCCCNC(=O)C5=CC(=C(C=C5)C6=C7C=CC(=O)C=C7OC8=C6C=CC(=C8)O)C(=O)O
CHEMBL3416749 oxyr_human Human No 8.8 Kd = 1.7 Funct
Binding affinity to SNAP-tagged oxytocin receptor (unknown origin) expressed in HEK293 cells by TR-FRET assayBinding affinity to SNAP-tagged oxytocin receptor (unknown origin) expressed in HEK293 cells by TR-FRET assay
1055 22 7 14 5.5 C1=CC2=C(C(=O)N=C2C=C1)NNC(=O)CN(C3=CC=C(C=C3)Cl)S(=O)(=O)C4=CC=C(C=C4)CCC(=O)NCCNC(=O)CCCCCNC(=O)C5=CC(=C(C=C5)C6=C7C=CC(=O)C=C7OC8=C6C=CC(=C8)O)C(=O)O
CHEMBL1790200 oxyr_rat Rat No 8.7 Kd = 1.8 Funct
In vitro Oxytocin receptor antagonistic activity against rat uterine stripsIn vitro Oxytocin receptor antagonistic activity against rat uterine strips
1033 9 12 15 -2.4 CCC(C)C1C(=O)NC2CCC(=O)NCCCCC(NC(=O)C3CCCN3C(=O)C(CSSC(C(C(=O)NC(C(=O)N1)CC4=CC=C(C=C4)O)N)(C)C)NC(=O)C(NC2=O)CC(=O)N)C(=O)NCC(=O)N
CHEMBL265630 oxyr_rat Rat Yes 8.0 Kd = 10 Funct
Antagonist activity in rat uterus by uterotonic assayAntagonist activity in rat uterus by uterotonic assay
1054 17 11 14 -0.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CC4=CC=CC=C4CC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL265630 oxyr_rat Rat Yes 8.0 Kd = 10 Funct
Antagonist activity in rat uterus by uterotonic assayAntagonist activity in rat uterus by uterotonic assay
1054 17 11 14 -0.7 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CC4=CC=CC=C4CC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL266898 oxyr_rat Rat No 8.0 Kd = 10.5 Funct
Biological activity against Oxytocin receptor in ratBiological activity against Oxytocin receptor in rat
1157 31 15 15 -0.8 CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)N)C(=O)NC(C(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N)C(C)(C)S)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)CC4(CCCCC4)S
CHEMBL3350125 oxyr_rat Rat No 8.0 Kd = 10.7 Funct
In vitro activity was determined for the anti-oxytocic activity with 0.5 mM Mg2+.In vitro activity was determined for the anti-oxytocic activity with 0.5 mM Mg2+.
1092 17 11 13 0.1 CC(C)C1C(=O)NC(C(=O)NC(CSSC2(CCCCC2)CC(=O)NC(C(=O)NC(C(=O)N1)CC3=CC=CC=C3)CC4=CC=CC=C4)C(=O)N5CCCC5C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N)CC(=O)N
CHEMBL3349465 oxyr_rat Rat No 8.0 Kd = 11.0 Funct
In vitro antioxycic activity with out Mg2+.In vitro antioxycic activity with out Mg2+.
1154 18 12 16 0.9 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSC2(CCCCC2)CC(=O)N(C(C(=O)N1)CC3=CC=C(C=C3)O)C)C(=O)N4CCCC4C(=O)NC(CCCN)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)N)CC(=O)N)C(C)O
CHEMBL539918 oxyr_rat Rat No 7.0 Kd = 100 Funct
Antagonist activity at oxytocin receptor in Wistar rat uterus assessed as inhibition of oxytocin-induced uterotonic activity treated 1 min prior to oxytocin challenge in absence of Mg2+Antagonist activity at oxytocin receptor in Wistar rat uterus assessed as inhibition of oxytocin-induced uterotonic activity treated 1 min prior to oxytocin challenge in absence of Mg2+
1115 18 12 14 -0.9 CC(C)C1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4)N)C(=O)N5CCCC5C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N)CC(=O)N
CHEMBL435159 oxyr_rat Rat Yes 7.0 Kd = 100 Funct
Antagonist activity in rat uterus by uterotonic assayAntagonist activity in rat uterus by uterotonic assay
1069 17 12 15 -1.5 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CC4=CC=CC=C4CC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
CHEMBL261938 oxyr_rat Rat No 7.0 Kd = 100 Funct
Uterotonic activity against OT receptor in Wistar rat in absence of magnesiumUterotonic activity against OT receptor in Wistar rat in absence of magnesium
1160 20 14 16 -3.4 C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=C(C=C3)O)C(C4=CC=CC=C4)C5=CC=CC=C5)N)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N
CHEMBL539918 oxyr_rat Rat No 7.0 Kd = 100 Funct
Antagonist activity at oxytocin receptor in Wistar rat uterus assessed as inhibition of oxytocin-induced uterotonic activity treated 1 min prior to oxytocin challenge in absence of Mg2+Antagonist activity at oxytocin receptor in Wistar rat uterus assessed as inhibition of oxytocin-induced uterotonic activity treated 1 min prior to oxytocin challenge in absence of Mg2+
1115 18 12 14 -0.9 CC(C)C1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4)N)C(=O)N5CCCC5C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N)CC(=O)N
CHEMBL435159 oxyr_rat Rat Yes 7.0 Kd = 100 Funct
Antagonist activity in rat uterus by uterotonic assay