Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Unit Assay Type Assay Description Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles
CHEMBL475027 ffar1_human Human No 10.0 EC50 = 0.1 Funct
Agonist activity at GPR40 expressed in CHO cells by FLIPR assayAgonist activity at GPR40 expressed in CHO cells by FLIPR assay
371 3 1 7 4.1 C1=CC(=C(C=C1C(F)(F)F)Cl)OC2=CC3=C(C=C2)C4C(C4O3)C(=O)O
CHEMBL475027 ffar1_human Human No 10.0 EC50 = 0.1 Funct
Agonist activity at GPR40 expressed in CHO cells by FLIPR assayAgonist activity at GPR40 expressed in CHO cells by FLIPR assay
371 3 1 7 4.1 C1=CC(=C(C=C1C(F)(F)F)Cl)OC2=CC3=C(C=C2)C4C(C4O3)C(=O)O
CHEMBL3265149 ffar1_human Human No 9.2 EC50 = 0.6 Funct
Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin
523 12 1 8 5.7 CC(C)(C)C(C1=C(C=CC(=C1)COC2=NC=CC(=C2)C(CC(=O)O)C3CC3)C4=CC(=NC=C4F)OC)OC
CHEMBL3265149 ffar1_human Human No 9.2 EC50 = 0.6 Funct
Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin
523 12 1 8 5.7 CC(C)(C)C(C1=C(C=CC(=C1)COC2=NC=CC(=C2)C(CC(=O)O)C3CC3)C4=CC(=NC=C4F)OC)OC
CHEMBL3287571 ffar1_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay
463 8 1 6 4.9 CC1=C(C=CC(=C1)Cl)C2=CC(=CC=C2)COC3=CC=C(C=C3)C(CC(=O)O)C4=NN=NN4C
CHEMBL3287571 ffar1_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay
463 8 1 6 4.9 CC1=C(C=CC(=C1)Cl)C2=CC(=CC=C2)COC3=CC=C(C=C3)C(CC(=O)O)C4=NN=NN4C
CHEMBL3265144 ffar1_human Human No 8.8 EC50 = 1.7 Funct
Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin
519 10 1 7 6.9 CC1(CCCC1C2=C(C=CC(=C2)COC3=NC=CC(=C3)C(CC(=O)O)C4CC4)C5=CC(=NC=C5F)OC)C
CHEMBL3265144 ffar1_human Human No 8.8 EC50 = 1.7 Funct
Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin
519 10 1 7 6.9 CC1(CCCC1C2=C(C=CC(=C2)COC3=NC=CC(=C3)C(CC(=O)O)C4CC4)C5=CC(=NC=C5F)OC)C
CHEMBL514337 ffar1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at GPR40Agonist activity at GPR40
403 6 1 4 5.5 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2CCC3=C2C=CC(=C3)C4=CC=CS4
CHEMBL604126 ffar1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
417 4 1 8 4.7 CC1=C(C=CC(=C1)OC2=C(C=C(C=N2)C(F)(F)F)Cl)CC3C(=O)NC(=O)S3
CHEMBL611821 ffar1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
432 6 2 8 5.1 CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)CNC3=CC=C(C=C3)C4CC4C(=O)O
CHEMBL3288358 ffar1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay
375 7 1 4 5.1 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=NC=C(C=C3)C(C)CC(=O)O
CHEMBL2022256 ffar1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA
495 9 1 5 6.5 CC1=C(C(=CC=C1)C)C2=C(C=CC(=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)OCC5=CC=CC=C5
CHEMBL514337 ffar1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at GPR40Agonist activity at GPR40
403 6 1 4 5.5 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2CCC3=C2C=CC(=C3)C4=CC=CS4
CHEMBL604126 ffar1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
417 4 1 8 4.7 CC1=C(C=CC(=C1)OC2=C(C=C(C=N2)C(F)(F)F)Cl)CC3C(=O)NC(=O)S3
CHEMBL611821 ffar1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
432 6 2 8 5.1 CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)CNC3=CC=C(C=C3)C4CC4C(=O)O
CHEMBL3288358 ffar1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay
375 7 1 4 5.1 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=NC=C(C=C3)C(C)CC(=O)O
CHEMBL2022256 ffar1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA
495 9 1 5 6.5 CC1=C(C(=CC=C1)C)C2=C(C=CC(=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)OCC5=CC=CC=C5
CHEMBL380884 ffar1_human Human No 8.0 EC50 = 11.0 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
474 7 2 7 5.7 CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)CNC3=CC=C(C=C3)C4CC4C(=O)NC(C)C
CHEMBL1829173 ffar1_human Human Yes 7.0 EC50 = 100 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
438 7 1 6 6.2 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC(=C2)C3=CC=C(C=C3)C(F)(F)F
CHEMBL207881 ffar1_human Human Yes 7.0 EC50 = 100 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
347 8 2 4 4.7 C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL3604043 ffar1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
360 11 1 6 2.9 CCOC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC(=CC=C2)OCOC
CHEMBL1777872 ffar1_mouse Mouse No 7.0 EC50 = 100 Funct
Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
432 6 1 5 5.6 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2CCCC3=C2SC(=N3)C4=CC=C(C=C4)C
CHEMBL203520 ffar1_human Human No 7.0 EC50 = 100 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
361 8 2 4 5.3 CC(CC1=CC=C(C=C1)NCC2=CC(=CC=C2)OC3=CC=CC=C3)C(=O)O
CHEMBL205263 ffar1_human Human No 7.0 EC50 = 100 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
462 8 2 7 5.7 CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)CNC3=CC=C(C=C3)CCC(=O)NC(C)C
CHEMBL1829173 ffar1_human Human Yes 7.0 EC50 = 100 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
438 7 1 6 6.2 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC(=C2)C3=CC=C(C=C3)C(F)(F)F
CHEMBL207881 ffar1_human Human Yes 7.0 EC50 = 100 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
347 8 2 4 4.7 C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL3604043 ffar1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
360 11 1 6 2.9 CCOC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC(=CC=C2)OCOC
CHEMBL1777872 ffar1_mouse Mouse No 7.0 EC50 = 100 Funct
Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
432 6 1 5 5.6 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2CCCC3=C2SC(=N3)C4=CC=C(C=C4)C
CHEMBL203520 ffar1_human Human No 7.0 EC50 = 100 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
361 8 2 4 5.3 CC(CC1=CC=C(C=C1)NCC2=CC(=CC=C2)OC3=CC=CC=C3)C(=O)O
CHEMBL205263 ffar1_human Human No 7.0 EC50 = 100 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
462 8 2 7 5.7 CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)CNC3=CC=C(C=C3)CCC(=O)NC(C)C
CHEMBL233835 ffar1_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor
290 6 2 3 3.8 C1=CC(=CC=C1CCC(=O)O)NCC2=CC=C(C=C2)Cl
CHEMBL233835 ffar1_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor
290 6 2 3 3.8 C1=CC(=CC=C1CCC(=O)O)NCC2=CC=C(C=C2)Cl
CHEMBL2315546 ffar1_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis
326 6 1 2 5.3 C1=CC=C(C=C1)C2=CC=CC=C2C#CC3=CC=C(C=C3)CCC(=O)O
CHEMBL2315557 ffar1_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis
264 6 1 2 4.4 C1=CC=C(C=C1)C#CC2=CC=C(C=C2)CCCC(=O)O
CHEMBL1688455 ffar1_human Human Yes 5.0 EC50 = 10000 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
332 7 1 3 4.8 C1=CC=C(C=C1)C2=CC=CC=C2COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3287569 ffar1_human Human No 5.0 EC50 = 10000 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum
461 8 1 4 5.3 CC1=C(C=CC(=C1)Cl)C2=CC(=CC=C2)COC3=CC=C(C=C3)C(CC(=O)O)C4=NC=CN4C
CHEMBL1688455 ffar1_human Human Yes 5.0 EC50 = 10000 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
332 7 1 3 4.8 C1=CC=C(C=C1)C2=CC=CC=C2COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3287569 ffar1_human Human No 5.0 EC50 = 10000 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum
461 8 1 4 5.3 CC1=C(C=CC(=C1)Cl)C2=CC(=CC=C2)COC3=CC=C(C=C3)C(CC(=O)O)C4=NC=CN4C
CHEMBL602867 ffar1_human Human No 7.0 EC50 = 101 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
368 4 1 4 4.8 C1=CC(=CC=C1CC2C(=O)NC(=O)S2)OC3=C(C=C(C=C3)Cl)Cl
CHEMBL602867 ffar1_human Human No 7.0 EC50 = 101 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
368 4 1 4 4.8 C1=CC(=CC=C1CC2C(=O)NC(=O)S2)OC3=C(C=C(C=C3)Cl)Cl
CHEMBL3798992 ffar1_human Human No 7.0 EC50 = 102 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
454 9 1 7 5.4 CC1=C(C(=NO1)C)C2=CC(=CC(=C2)OC3CCCC3)COC4=CC(=C(C=C4)CCC(=O)O)F
CHEMBL3798992 ffar1_human Human No 7.0 EC50 = 102 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
454 9 1 7 5.4 CC1=C(C(=NO1)C)C2=CC(=CC(=C2)OC3CCCC3)COC4=CC(=C(C=C4)CCC(=O)O)F
CHEMBL3628763 ffar1_human Human No 7.0 EC50 = 103.6 Funct
Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay
454 11 1 7 5.2 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC(=C(C=C3)OCC(=O)O)F)C)OCCOC
CHEMBL3628763 ffar1_human Human No 7.0 EC50 = 103.6 Funct
Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay
454 11 1 7 5.2 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC(=C(C=C3)OCC(=O)O)F)C)OCCOC
CHEMBL1829173 ffar1_human Human Yes 7.0 EC50 = 104 Funct
Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay
438 7 1 6 6.2 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC(=C2)C3=CC=C(C=C3)C(F)(F)F
CHEMBL1777855 ffar1_mouse Mouse No 7.0 EC50 = 104 Funct
Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
432 7 1 10 5.7 CC#CC(CC(=O)O)C1=C(C=C(C=C1)OC2=C(C=C(C=C2)C(F)(F)F)OC(F)F)F
CHEMBL1829173 ffar1_human Human Yes 7.0 EC50 = 104 Funct
Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay
438 7 1 6 6.2 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC(=C2)C3=CC=C(C=C3)C(F)(F)F
CHEMBL1777855 ffar1_mouse Mouse No 7.0 EC50 = 104 Funct
Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
432 7 1 10 5.7 CC#CC(CC(=O)O)C1=C(C=C(C=C1)OC2=C(C=C(C=C2)C(F)(F)F)OC(F)F)F
CHEMBL3265139 ffar1_human Human No 7.0 EC50 = 105 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
509 11 1 6 7.7 CC(C)(C)C(C1=C(C=CC(=C1)COC2=CC=CC(=C2)C(CC(=O)O)C3CC3)C4=C(C=CC(=C4)OC)F)F
CHEMBL3265139 ffar1_human Human No 7.0 EC50 = 105 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
509 11 1 6 7.7 CC(C)(C)C(C1=C(C=CC(=C1)COC2=CC=CC(=C2)C(CC(=O)O)C3CC3)C4=C(C=CC(=C4)OC)F)F
CHEMBL2385464 ffar1_human Human No 7.0 EC50 = 105 Funct
Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay
548 7 1 7 7.9 CC1(CCCC1C2=C(C=CC(=C2)COC3=C(C4=C(CCCC45CC5C(=O)O)C=C3)F)C6=CC(=NC=C6F)OC)C
CHEMBL2381292 ffar1_human Human No 7.0 EC50 = 105.1 Funct
Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay
409 3 1 6 3.3 C1C(C2=CC3=C(C=C2O1)OC(CO3)C4=CC(=CC(=C4)Br)F)CC(=O)O
CHEMBL3628757 ffar1_human Human No 7.0 EC50 = 105.8 Funct
Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay
438 10 1 6 6.3 CCCOC1=CC(=C(C(=C1)C)C2=CC(=CC=C2)COC3=CC(=C(C=C3)OCC(=O)O)F)C
CHEMBL3628757 ffar1_human Human No 7.0 EC50 = 105.8 Funct
Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay
438 10 1 6 6.3 CCCOC1=CC(=C(C(=C1)C)C2=CC(=CC=C2)COC3=CC(=C(C=C3)OCC(=O)O)F)C
CHEMBL3806208 ffar1_human Human No 6.0 EC50 = 1060 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay
383 8 2 7 2.8 C1=CC=C(C=C1)NC(=O)C2=NN=C(S2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3806208 ffar1_human Human No 6.0 EC50 = 1060 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay
383 8 2 7 2.8 C1=CC=C(C=C1)NC(=O)C2=NN=C(S2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3805377 ffar1_human Human No 5.0 EC50 = 10620 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay
418 8 2 7 3.4 C1=CC(=CC(=C1)Cl)NC(=O)C2=NN=C(S2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3805377 ffar1_human Human No 5.0 EC50 = 10620 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay
418 8 2 7 3.4 C1=CC(=CC(=C1)Cl)NC(=O)C2=NN=C(S2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL485738 ffar1_human Human No 7.0 EC50 = 107.2 Funct
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay
264 5 1 2 4.1 CC1=CC=C(C=C1)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL485738 ffar1_human Human No 7.0 EC50 = 107.2 Funct
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay
264 5 1 2 4.1 CC1=CC=C(C=C1)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL3600997 ffar1_human Human Yes 6.0 EC50 = 1070 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
341 7 1 6 3.4 C1=CC(=CC(=C1)F)C2=CN=C(O2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3600997 ffar1_human Human Yes 6.0 EC50 = 1070 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
341 7 1 6 3.4 C1=CC(=CC(=C1)F)C2=CN=C(O2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL1829163 ffar1_human Human No 6.0 EC50 = 1071.5 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
341 6 1 3 4.7 CC1=CC=CC=C1C2=NC=CC(=C2)C#CC3=CC=C(C=C3)CCC(=O)O
CHEMBL1773259 ffar1_human Human No 6.0 EC50 = 1071.5 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
331 7 2 3 4.8 C1=CC=C(C=C1)C2=CC=CC=C2CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL1829163 ffar1_human Human No 6.0 EC50 = 1071.5 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
341 6 1 3 4.7 CC1=CC=CC=C1C2=NC=CC(=C2)C#CC3=CC=C(C=C3)CCC(=O)O
CHEMBL1773259 ffar1_human Human No 6.0 EC50 = 1071.5 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
331 7 2 3 4.8 C1=CC=C(C=C1)C2=CC=CC=C2CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL3265144 ffar1_human Human No 7.0 EC50 = 108 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
519 10 1 7 6.9 CC1(CCCC1C2=C(C=CC(=C2)COC3=NC=CC(=C3)C(CC(=O)O)C4CC4)C5=CC(=NC=C5F)OC)C
CHEMBL1777866 ffar1_human Human No 7.0 EC50 = 108 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
384 5 1 7 4.6 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=C(C=C(C=N2)C(F)(F)F)Cl
CHEMBL3265144 ffar1_human Human No 7.0 EC50 = 108 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
519 10 1 7 6.9 CC1(CCCC1C2=C(C=CC(=C2)COC3=NC=CC(=C3)C(CC(=O)O)C4CC4)C5=CC(=NC=C5F)OC)C
CHEMBL1777866 ffar1_human Human No 7.0 EC50 = 108 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
384 5 1 7 4.6 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=C(C=C(C=N2)C(F)(F)F)Cl
CHEMBL3616657 ffar1_human Human No 7.0 EC50 = 108.2 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method
333 7 2 6 2.8 CC1=CC(=CC=C1)OCC(=O)NC2=CC(=C(C=C2)OCC(=O)O)F
CHEMBL3616657 ffar1_human Human No 7.0 EC50 = 108.2 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method
333 7 2 6 2.8 CC1=CC(=CC=C1)OCC(=O)NC2=CC(=C(C=C2)OCC(=O)O)F
CHEMBL598040 ffar1_human Human No 6.0 EC50 = 1082 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
311 5 1 3 4.3 C1=CC=C(C=C1)CCC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL598040 ffar1_human Human No 6.0 EC50 = 1082 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
311 5 1 3 4.3 C1=CC=C(C=C1)CCC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL603065 ffar1_human Human No 6.0 EC50 = 1087 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
314 4 1 5 3.2 CC1=C(N=CC=C1)OC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL603065 ffar1_human Human No 6.0 EC50 = 1087 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
314 4 1 5 3.2 CC1=C(N=CC=C1)OC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL3629046 ffar1_human Human No 7.0 EC50 = 109.5 Funct
Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay
454 11 2 7 5.1 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC(=C(C=C3)OCC(=O)O)F)C)OCCCO
CHEMBL3629046 ffar1_human Human No 7.0 EC50 = 109.5 Funct
Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay
454 11 2 7 5.1 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC(=C(C=C3)OCC(=O)O)F)C)OCCCO
CHEMBL2058530 ffar1_human Human No 7.0 EC50 = 109.7 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
367 7 1 3 5.4 C1=CC=C(C=C1)C2=C(C=CC(=C2)Cl)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL2058530 ffar1_human Human No 7.0 EC50 = 109.7 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
367 7 1 3 5.4 C1=CC=C(C=C1)C2=C(C=CC(=C2)Cl)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL446575 ffar1_human Human No 6.0 EC50 = 1096.5 Funct
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay
265 5 2 3 3.0 C1=CC(=CC(=C1)N)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL446575 ffar1_human Human No 6.0 EC50 = 1096.5 Funct
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay
265 5 2 3 3.0 C1=CC(=CC(=C1)N)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL1829147 ffar1_human Human No 5.0 EC50 = 10964.8 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
296 5 1 5 2.5 C1=CC(=C(N=C1)C#CC2=CC=C(C=C2)CCC(=O)O)[N+](=O)[O-]
CHEMBL1829147 ffar1_human Human No 5.0 EC50 = 10964.8 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
296 5 1 5 2.5 C1=CC(=C(N=C1)C#CC2=CC=C(C=C2)CCC(=O)O)[N+](=O)[O-]
CHEMBL3287570 ffar1_human Human No 8.0 EC50 = 11 Funct
Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay
462 8 1 5 5.3 CC1=C(C=CC(=C1)Cl)C2=CC(=CC=C2)COC3=CC=C(C=C3)C(CC(=O)O)C4=NC=NN4C
CHEMBL3427712 ffar1_rat Rat Yes 8.0 EC50 = 11 Funct
Agonist activity at rat GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at rat GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
394 7 1 7 4.2 CCOC(CC(=O)O)C1=CC=C(C=C1)OC2CCC3=C2C=CC=C3C(F)(F)F
CHEMBL3287570 ffar1_human Human No 8.0 EC50 = 11 Funct
Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay
462 8 1 5 5.3 CC1=C(C=CC(=C1)Cl)C2=CC(=CC=C2)COC3=CC=C(C=C3)C(CC(=O)O)C4=NC=NN4C
CHEMBL3427712 ffar1_rat Rat Yes 8.0 EC50 = 11 Funct
Agonist activity at rat GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at rat GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
394 7 1 7 4.2 CCOC(CC(=O)O)C1=CC=C(C=C1)OC2CCC3=C2C=CC=C3C(F)(F)F
CHEMBL3798044 ffar1_human Human No 8.0 EC50 = 11.1 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
387 7 1 7 4.2 CC1=C(C(=NO1)C)C2=CC(=C(C=C2)F)COC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL3798044 ffar1_human Human No 8.0 EC50 = 11.1 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
387 7 1 7 4.2 CC1=C(C(=NO1)C)C2=CC(=C(C=C2)F)COC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL1773261 ffar1_human Human No 8.0 EC50 = 11.2 Funct
Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay
345 7 2 3 5.1 CC1=CC=CC=C1C2=CC(=CC=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL1773261 ffar1_human Human No 8.0 EC50 = 11.2 Funct
Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay
345 7 2 3 5.1 CC1=CC=CC=C1C2=CC(=CC=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL2381289 ffar1_human Human No 8.0 EC50 = 11.3 Funct
Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay
380 3 1 8 3.3 C1C(C2=CC3=C(C=C2O1)OC(CO3)C4=CC(=CC=C4)C(F)(F)F)CC(=O)O
CHEMBL1939650 ffar1_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay
324 7 1 4 3.7 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC(=CC=C2)OC
CHEMBL1939650 ffar1_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay
324 7 1 4 3.7 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC(=CC=C2)OC
CHEMBL3628762 ffar1_human Human No 7.0 EC50 = 110.3 Funct
Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay
396 7 2 6 5.1 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC(=C(C=C3)OCC(=O)O)F)C)O
CHEMBL3628762 ffar1_human Human No 7.0 EC50 = 110.3 Funct
Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay
396 7 2 6 5.1 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC(=C(C=C3)OCC(=O)O)F)C)O
CHEMBL1688456 ffar1_human Human No 6.0 EC50 = 1100 Funct
Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA
348 8 1 4 4.7 C1=CC=C(C=C1)OC2=CC=CC=C2COC3=CC=C(C=C3)CCC(=O)O
CHEMBL2152071 ffar1_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
515 10 1 5 7.8 CC1(CCC=C1C2=C(C=CC(=C2)COC3=CC=CC(=C3)C(CC(=O)O)C4CC4)C5=C(C=CC(=C5)OC)F)C
CHEMBL1939637 ffar1_human Human Yes 6.0 EC50 = 1100 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay
286 7 1 4 3.4 COC1=CC=C(C=C1)COC2=CC=C(C=C2)CCC(=O)O
CHEMBL3288352 ffar1_rat Rat No 6.0 EC50 = 1100 Funct
Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay
375 7 1 4 5.2 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=NC(=C(C=C3)CCC(=O)O)C
CHEMBL1688456 ffar1_human Human No 6.0 EC50 = 1100 Funct
Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA
348 8 1 4 4.7 C1=CC=C(C=C1)OC2=CC=CC=C2COC3=CC=C(C=C3)CCC(=O)O
CHEMBL2152071 ffar1_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
515 10 1 5 7.8 CC1(CCC=C1C2=C(C=CC(=C2)COC3=CC=CC(=C3)C(CC(=O)O)C4CC4)C5=C(C=CC(=C5)OC)F)C
CHEMBL1939637 ffar1_human Human Yes 6.0 EC50 = 1100 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay
286 7 1 4 3.4 COC1=CC=C(C=C1)COC2=CC=C(C=C2)CCC(=O)O
CHEMBL3288352 ffar1_rat Rat No 6.0 EC50 = 1100 Funct
Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay
375 7 1 4 5.2 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=NC(=C(C=C3)CCC(=O)O)C
CHEMBL8739 ffar1_human Human Yes 5.0 EC50 = 11090 Funct
Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay
278 13 1 2 5.9 CCC=CCC=CCC=CCCCCCCCC(=O)O
CHEMBL2381283 ffar1_human Human No 7.0 EC50 = 111.1 Funct
Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay
391 3 1 5 3.2 C1C(C2=CC3=C(C=C2O1)OC(CO3)C4=CC(=CC=C4)Br)CC(=O)O
CHEMBL3601006 ffar1_human Human Yes 6.0 EC50 = 1110 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
392 7 1 9 3.9 C1=CC(=CC(=C1)C(F)(F)F)C2=NOC(=N2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3601006 ffar1_human Human Yes 6.0 EC50 = 1110 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
392 7 1 9 3.9 C1=CC(=CC(=C1)C(F)(F)F)C2=NOC(=N2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3754173 ffar1_human Human No 7.0 EC50 = 112 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin
496 9 1 8 5.5 CN1C=CN=C1C(CC(=O)O)C2=CC=C(C=C2)OCC3=CC=CC(=C3)C4=CC=CC=C4OC(F)(F)F
CHEMBL3754173 ffar1_human Human No 7.0 EC50 = 112 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin
496 9 1 8 5.5 CN1C=CN=C1C(CC(=O)O)C2=CC=C(C=C2)OCC3=CC=CC(=C3)C4=CC=CC=C4OC(F)(F)F
CHEMBL1829157 ffar1_human Human No 6.0 EC50 = 1122.0 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
265 5 1 3 3.0 CC1=NC=CC(=C1)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL205090 ffar1_human Human No 6.0 EC50 = 1122.0 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
361 9 2 4 5.0 C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCCC(=O)O
CHEMBL1829157 ffar1_human Human No 6.0 EC50 = 1122.0 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
265 5 1 3 3.0 CC1=NC=CC(=C1)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL205090 ffar1_human Human No 6.0 EC50 = 1122.0 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
361 9 2 4 5.0 C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCCC(=O)O
CHEMBL599067 ffar1_human Human Yes 5.0 EC50 = 11270 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
299 4 1 4 3.6 C1=CC=C(C=C1)OC2=CC=CC=C2CC3C(=O)NC(=O)S3
CHEMBL599067 ffar1_human Human Yes 5.0 EC50 = 11270 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
299 4 1 4 3.6 C1=CC=C(C=C1)OC2=CC=CC=C2CC3C(=O)NC(=O)S3
CHEMBL1777855 ffar1_human Human No 7.0 EC50 = 113 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
432 7 1 10 5.7 CC#CC(CC(=O)O)C1=C(C=C(C=C1)OC2=C(C=C(C=C2)C(F)(F)F)OC(F)F)F
CHEMBL1777855 ffar1_human Human No 7.0 EC50 = 113 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
432 7 1 10 5.7 CC#CC(CC(=O)O)C1=C(C=C(C=C1)OC2=C(C=C(C=C2)C(F)(F)F)OC(F)F)F
CHEMBL3601007 ffar1_human Human Yes 6.0 EC50 = 1130 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
324 7 1 6 3.1 C1=CC=C(C=C1)C2=NOC(=N2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3601007 ffar1_human Human Yes 6.0 EC50 = 1130 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
324 7 1 6 3.1 C1=CC=C(C=C1)C2=NOC(=N2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3265141 ffar1_human Human No 6.9 EC50 = 114 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
535 13 1 6 7.5 CCOC(C1=C(C=CC(=C1)COC2=CC=CC(=C2)C(CC(=O)O)C3CC3)C4=C(C=CC(=C4)OC)F)C(C)(C)C
CHEMBL1777873 ffar1_human Human No 6.9 EC50 = 114 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
272 5 1 3 3.5 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2CCCC2
CHEMBL3798642 ffar1_human Human No 6.9 EC50 = 114 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
437 7 1 9 5.0 CC1=C(C(=NO1)C)C2=CC(=CC(=C2)C(F)(F)F)COC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL3265141 ffar1_human Human No 6.9 EC50 = 114 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
535 13 1 6 7.5 CCOC(C1=C(C=CC(=C1)COC2=CC=CC(=C2)C(CC(=O)O)C3CC3)C4=C(C=CC(=C4)OC)F)C(C)(C)C
CHEMBL1777873 ffar1_human Human No 6.9 EC50 = 114 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
272 5 1 3 3.5 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2CCCC2
CHEMBL3798642 ffar1_human Human No 6.9 EC50 = 114 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
437 7 1 9 5.0 CC1=C(C(=NO1)C)C2=CC(=CC(=C2)C(F)(F)F)COC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL382341 ffar1_human Human No 6.9 EC50 = 114.8 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
401 8 1 3 5.1 C1CCN(C1)C(=O)CCC2=CC=C(C=C2)NCC3=CC(=CC=C3)OC4=CC=CC=C4
CHEMBL382341 ffar1_human Human No 6.9 EC50 = 114.8 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
401 8 1 3 5.1 C1CCN(C1)C(=O)CCC2=CC=C(C=C2)NCC3=CC(=CC=C3)OC4=CC=CC=C4
CHEMBL2058524 ffar1_human Human No 5.9 EC50 = 1148.2 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
400 7 1 6 5.7 C1=CC=C(C(=C1)COC2=CC=C(C=C2)CCC(=O)O)C3=CC=C(C=C3)C(F)(F)F
CHEMBL234834 ffar1_human Human Yes 5.9 EC50 = 1148.2 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
255 6 2 3 2.9 C1=CC=C(C=C1)CNC2=CC=C(C=C2)CCC(=O)O
CHEMBL2058524 ffar1_human Human No 5.9 EC50 = 1148.2 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
400 7 1 6 5.7 C1=CC=C(C(=C1)COC2=CC=C(C=C2)CCC(=O)O)C3=CC=C(C=C3)C(F)(F)F
CHEMBL234834 ffar1_human Human Yes 5.9 EC50 = 1148.2 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
255 6 2 3 2.9 C1=CC=C(C=C1)CNC2=CC=C(C=C2)CCC(=O)O
CHEMBL121 ffar1_human Human Yes 4.9 EC50 = 11481.5 Funct
Agonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylationAgonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylation
357 7 1 6 3.1 CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3
CHEMBL108766 ffar1_human Human Yes 4.9 EC50 = 11481.5 Funct
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in Flp-In T-Rex 293 cells assessed as induction of Ca2+ mobilization after 45 mins by Fura2-AM dye-based fluorescence assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in Flp-In T-Rex 293 cells assessed as induction of Ca2+ mobilization after 45 mins by Fura2-AM dye-based fluorescence assay
200 10 1 2 4.2 CCCCCCCCCCCC(=O)O
CHEMBL121 ffar1_human Human Yes 4.9 EC50 = 11481.5 Funct
Agonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylationAgonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylation
357 7 1 6 3.1 CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3
CHEMBL3616660 ffar1_human Human No 6.9 EC50 = 115.6 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method
361 8 2 6 3.6 CC(C)C1=CC(=CC=C1)OCC(=O)NC2=CC(=C(C=C2)OCC(=O)O)F
CHEMBL3616660 ffar1_human Human No 6.9 EC50 = 115.6 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method
361 8 2 6 3.6 CC(C)C1=CC(=CC=C1)OCC(=O)NC2=CC(=C(C=C2)OCC(=O)O)F
CHEMBL3759212 ffar1_human Human No 5.9 EC50 = 1150 Funct
Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay
418 6 1 4 5.9 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4
CHEMBL3759212 ffar1_human Human No 5.9 EC50 = 1150 Funct
Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay
418 6 1 4 5.9 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4
CHEMBL367149 ffar1_human Human Yes 4.9 EC50 = 11700 Funct
Agonist activity at GPR40 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR40 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay
329 14 1 2 6.2 CCC=CCC=CCC=CCC=CCC=CCC=CCCC(=O)O
CHEMBL367149 ffar1_human Human Yes 4.9 EC50 = 11700 Funct
Agonist activity at GPR40 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR40 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay
329 14 1 2 6.2 CCC=CCC=CCC=CCC=CCC=CCC=CCCC(=O)O
CHEMBL3781145 ffar1_human Human No 6.9 EC50 = 118.5 Funct
Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay
395 6 1 6 4.2 CC1=CC=CC(=C1)C2=NC(=C(S2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C
CHEMBL3781145 ffar1_human Human No 6.9 EC50 = 118.5 Funct
Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay
395 6 1 6 4.2 CC1=CC=CC(=C1)C2=NC(=C(S2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C
CHEMBL598674 ffar1_human Human No 5.9 EC50 = 1189 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
334 4 1 4 4.2 C1=CC=C(C(=C1)OC2=CC=C(C=C2)CC3C(=O)NC(=O)S3)Cl
CHEMBL598674 ffar1_human Human No 5.9 EC50 = 1189 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
334 4 1 4 4.2 C1=CC=C(C(=C1)OC2=CC=C(C=C2)CC3C(=O)NC(=O)S3)Cl
CHEMBL3805903 ffar1_human Human No 5.9 EC50 = 1190 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay
401 8 2 8 2.9 C1=CC(=CC(=C1)F)NC(=O)C2=NN=C(S2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3805903 ffar1_human Human No 5.9 EC50 = 1190 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay
401 8 2 8 2.9 C1=CC(=CC(=C1)F)NC(=O)C2=NN=C(S2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3604061 ffar1_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
354 8 1 4 4.2 CCC1=CC=CC2=C1CCC2OC3=CC=C(C=C3)C(CC(=O)O)OCC
CHEMBL3604047 ffar1_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
335 8 1 4 3.6 CCOC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=C(C=C2)Cl
CHEMBL3604037 ffar1_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
387 8 1 5 4.3 CCOC(CC(=O)O)C1=C(C=C(C=C1)OCC2=CC(=C(C=C2)Cl)Cl)F
CHEMBL3604062 ffar1_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
368 8 1 4 4.5 CCOC(CC(=O)O)C1=CC=C(C=C1)OC2CCC3=C2C=CC=C3C(C)C
CHEMBL3800362 ffar1_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
383 7 1 6 4.5 CC1=CC(=CC(=C1)C2=C(ON=C2C)C)COC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL3287571 ffar1_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay
463 8 1 6 4.9 CC1=C(C=CC(=C1)Cl)C2=CC(=CC=C2)COC3=CC=C(C=C3)C(CC(=O)O)C4=NN=NN4C
CHEMBL2048614 ffar1_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
390 8 1 4 5.5 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O)C)OC
CHEMBL3604061 ffar1_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
354 8 1 4 4.2 CCC1=CC=CC2=C1CCC2OC3=CC=C(C=C3)C(CC(=O)O)OCC
CHEMBL3604047 ffar1_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
335 8 1 4 3.6 CCOC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=C(C=C2)Cl
CHEMBL3604037 ffar1_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
387 8 1 5 4.3 CCOC(CC(=O)O)C1=C(C=C(C=C1)OCC2=CC(=C(C=C2)Cl)Cl)F
CHEMBL3604062 ffar1_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
368 8 1 4 4.5 CCOC(CC(=O)O)C1=CC=C(C=C1)OC2CCC3=C2C=CC=C3C(C)C
CHEMBL3800362 ffar1_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
383 7 1 6 4.5 CC1=CC(=CC(=C1)C2=C(ON=C2C)C)COC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL3287571 ffar1_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay
463 8 1 6 4.9 CC1=C(C=CC(=C1)Cl)C2=CC(=CC=C2)COC3=CC=C(C=C3)C(CC(=O)O)C4=NN=NN4C
CHEMBL2048614 ffar1_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
390 8 1 4 5.5 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O)C)OC
CHEMBL207753 ffar1_human Human No 7.9 EC50 = 12.3 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
359 7 2 4 4.6 C1C(C1C(=O)O)C2=CC=C(C=C2)NCC3=CC(=CC=C3)OC4=CC=CC=C4
CHEMBL207753 ffar1_human Human No 7.9 EC50 = 12.3 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
359 7 2 4 4.6 C1C(C1C(=O)O)C2=CC=C(C=C2)NCC3=CC(=CC=C3)OC4=CC=CC=C4
CHEMBL203126 ffar1_human Human No 7.9 EC50 = 12.6 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
401 8 2 3 5.2 CC(C)NC(=O)C1CC1C2=CC=C(C=C2)NCC3=CC(=CC=C3)OC4=CC=CC=C4
CHEMBL203126 ffar1_human Human No 7.9 EC50 = 12.6 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
401 8 2 3 5.2 CC(C)NC(=O)C1CC1C2=CC=C(C=C2)NCC3=CC(=CC=C3)OC4=CC=CC=C4
CHEMBL1773261 ffar1_human Human No 7.9 EC50 = 12.9 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
345 7 2 3 5.1 CC1=CC=CC=C1C2=CC(=CC=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL381958 ffar1_human Human No 7.9 EC50 = 12.9 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
419 7 2 7 4.5 CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)CNC3=CC=C(C=C3)CCC(=O)N
CHEMBL1773261 ffar1_human Human No 7.9 EC50 = 12.9 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
345 7 2 3 5.1 CC1=CC=CC=C1C2=CC(=CC=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL381958 ffar1_human Human No 7.9 EC50 = 12.9 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
419 7 2 7 4.5 CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)CNC3=CC=C(C=C3)CCC(=O)N
CHEMBL1688463 ffar1_human Human No 6.9 EC50 = 120 Funct
Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA
346 7 1 3 5.1 CC1=CC=C(C=C1)C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL1688483 ffar1_human Human No 6.9 EC50 = 120 Funct
Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA
350 7 1 4 4.9 C1=CC=C(C(=C1)C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O)F
CHEMBL3264817 ffar1_human Human No 6.9 EC50 = 120 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
516 10 1 6 7.1 CC1(CCC=C1C2=C(C=CC(=C2)COC3=CC=CC(=C3)C(CC(=O)O)C4CC4)C5=CC(=NC=C5F)OC)C
CHEMBL596667 ffar1_human Human No 6.9 EC50 = 120 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
352 4 1 5 4.0 CC1=CC(=CC(=C1C#N)C)OC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL1939641 ffar1_human Human No 6.9 EC50 = 120 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay
340 8 1 4 4.6 CC(=CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=C(C=C2)OC)C
CHEMBL3604060 ffar1_human Human No 6.9 EC50 = 120 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
341 7 1 6 3.5 CCOC(CC(=O)O)C1=CC=C(C=C1)OC2=NOC3=C2C=CC=C3C
CHEMBL3288356 ffar1_human Human No 6.9 EC50 = 120 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay
391 8 1 5 4.7 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=NC=C(C=C3)CC(C(=O)O)OC
CHEMBL3752026 ffar1_human Human No 6.9 EC50 = 120 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis
484 8 1 8 6.2 C1=CC(=CC(=C1)COC2=CC=C(C=C2)C(CC(=O)O)C3=NC=CS3)C4=CC=C(C=C4)C(F)(F)F
CHEMBL1688463 ffar1_human Human No 6.9 EC50 = 120 Funct
Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA
346 7 1 3 5.1 CC1=CC=C(C=C1)C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL1688483 ffar1_human Human No 6.9 EC50 = 120 Funct
Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA
350 7 1 4 4.9 C1=CC=C(C(=C1)C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O)F
CHEMBL3264817 ffar1_human Human No 6.9 EC50 = 120 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
516 10 1 6 7.1 CC1(CCC=C1C2=C(C=CC(=C2)COC3=CC=CC(=C3)C(CC(=O)O)C4CC4)C5=CC(=NC=C5F)OC)C
CHEMBL596667 ffar1_human Human No 6.9 EC50 = 120 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
352 4 1 5 4.0 CC1=CC(=CC(=C1C#N)C)OC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL1939641 ffar1_human Human No 6.9 EC50 = 120 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay
340 8 1 4 4.6 CC(=CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=C(C=C2)OC)C
CHEMBL3604060 ffar1_human Human No 6.9 EC50 = 120 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
341 7 1 6 3.5 CCOC(CC(=O)O)C1=CC=C(C=C1)OC2=NOC3=C2C=CC=C3C
CHEMBL3288356 ffar1_human Human No 6.9 EC50 = 120 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay
391 8 1 5 4.7 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=NC=C(C=C3)CC(C(=O)O)OC
CHEMBL3752026 ffar1_human Human No 6.9 EC50 = 120 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis
484 8 1 8 6.2 C1=CC(=CC(=C1)COC2=CC=C(C=C2)C(CC(=O)O)C3=NC=CS3)C4=CC=C(C=C4)C(F)(F)F
CHEMBL1829165 ffar1_human Human No 6.9 EC50 = 120.2 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
283 5 1 4 3.4 CC1=C(C=CN=C1F)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL1688482 ffar1_human Human No 6.9 EC50 = 120.2 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
362 8 1 4 4.7 COC1=CC=CC=C1C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL1829165 ffar1_human Human No 6.9 EC50 = 120.2 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
283 5 1 4 3.4 CC1=C(C=CN=C1F)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL1688482 ffar1_human Human No 6.9 EC50 = 120.2 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
362 8 1 4 4.7 COC1=CC=CC=C1C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL2381298 ffar1_human Human No 6.9 EC50 = 120.7 Funct
Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay
571 9 1 9 4.6 CC1=CC(=C(C(=C1C2=CC(=CC=C2)C3COC4=C(O3)C=C5C(=C4)C(CO5)CC(=O)O)C)F)OCCCS(=O)(=O)C
CHEMBL3601008 ffar1_human Human Yes 5.9 EC50 = 1200 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
359 7 1 6 3.7 C1=CC=C(C(=C1)C2=NOC(=N2)COC3=CC=C(C=C3)CCC(=O)O)Cl
CHEMBL2151292 ffar1_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
380 8 1 5 4.8 COC1=CC(=C(C=C1)F)C2=CC=C(C=C2)COC3=CC=CC(=C3)CCC(=O)O
CHEMBL2151302 ffar1_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
513 10 1 5 8.0 CC(C)(C)C1=C(C=CC(=C1)COC2=CC=CC(=C2)C(CC(=O)O)C3=CC=CC=C3)C4=C(C=CC(=C4)OC)F
CHEMBL207881 ffar1_human Human Yes 5.9 EC50 = 1200 Funct
Agonist activity at human GPR40 H86F mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 H86F mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calcium
347 8 2 4 4.7 C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL1939651 ffar1_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay
370 7 1 3 5.4 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=C(C=C2)C3=CC=CC=C3
CHEMBL1939642 ffar1_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay
326 7 1 4 4.7 CC(=C(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=C(C=C2)OC)C
CHEMBL3601008 ffar1_human Human Yes 5.9 EC50 = 1200 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
359 7 1 6 3.7 C1=CC=C(C(=C1)C2=NOC(=N2)COC3=CC=C(C=C3)CCC(=O)O)Cl
CHEMBL2151292 ffar1_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
380 8 1 5 4.8 COC1=CC(=C(C=C1)F)C2=CC=C(C=C2)COC3=CC=CC(=C3)CCC(=O)O
CHEMBL2151302 ffar1_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
513 10 1 5 8.0 CC(C)(C)C1=C(C=CC(=C1)COC2=CC=CC(=C2)C(CC(=O)O)C3=CC=CC=C3)C4=C(C=CC(=C4)OC)F
CHEMBL207881 ffar1_human Human Yes 5.9 EC50 = 1200 Funct
Agonist activity at human GPR40 H86F mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 H86F mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calcium
347 8 2 4 4.7 C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL1939651 ffar1_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay
370 7 1 3 5.4 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=C(C=C2)C3=CC=CC=C3
CHEMBL1939642 ffar1_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay
326 7 1 4 4.7 CC(=C(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=C(C=C2)OC)C
CHEMBL599280 ffar1_human Human No 6.9 EC50 = 121 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
327 4 1 4 4.3 CC1=CC(=C(C=C1)OC2=CC=C(C=C2)CC3C(=O)NC(=O)S3)C
CHEMBL599280 ffar1_human Human No 6.9 EC50 = 121 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
327 4 1 4 4.3 CC1=CC(=C(C=C1)OC2=CC=C(C=C2)CC3C(=O)NC(=O)S3)C
CHEMBL3353261 ffar1_human Human No 6.9 EC50 = 121.1 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assay
499 12 1 7 5.0 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC=C(C=C3)OCC(=O)O)C)OCCCS(=O)(=O)C
CHEMBL3353261 ffar1_human Human No 6.9 EC50 = 121.1 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assay
499 12 1 7 5.0 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC=C(C=C3)OCC(=O)O)C)OCCCS(=O)(=O)C
CHEMBL3616662 ffar1_human Human No 6.9 EC50 = 121.7 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method
375 8 2 6 4.1 CC(C)(C)C1=CC(=CC=C1)OCC(=O)NC2=CC(=C(C=C2)OCC(=O)O)F
CHEMBL3616662 ffar1_human Human No 6.9 EC50 = 121.7 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method
375 8 2 6 4.1 CC(C)(C)C1=CC(=CC=C1)OCC(=O)NC2=CC(=C(C=C2)OCC(=O)O)F
CHEMBL2381301 ffar1_human Human No 6.9 EC50 = 122.6 Funct
Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay
539 9 1 8 4.2 CC1=C(C=CC(=C1)OCCCS(=O)(=O)C)C2=CC(=CC=C2)C3COC4=C(O3)C=C5C(=C4)C(CO5)CC(=O)O
CHEMBL254859 ffar1_human Human Yes 4.9 EC50 = 12200 Funct
Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay
385 7 1 5 4.8 C1=CC=C2C(=C1)C=CC=C2C=C3C(=O)N(C(=S)S3)CCCCCC(=O)O
CHEMBL254859 ffar1_human Human Yes 4.9 EC50 = 12200 Funct
Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay
385 7 1 5 4.8 C1=CC=C2C(=C1)C=CC=C2C=C3C(=O)N(C(=S)S3)CCCCCC(=O)O
CHEMBL2315541 ffar1_human Human No 6.9 EC50 = 123.0 Funct
Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis
278 5 1 2 4.4 CC1=CC(=C(C=C1)C)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL3781779 ffar1_human Human No 6.9 EC50 = 123.4 Funct
Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay
411 7 1 7 3.8 CC1=C(SC(=N1)C2=CC=C(C=C2)OC)COC3=CC4=C(C=C3)C(CO4)CC(=O)O
CHEMBL3781779 ffar1_human Human No 6.9 EC50 = 123.4 Funct
Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay
411 7 1 7 3.8 CC1=C(SC(=N1)C2=CC=C(C=C2)OC)COC3=CC4=C(C=C3)C(CO4)CC(=O)O
CHEMBL233223 ffar1_human Human No 4.9 EC50 = 12302.7 Funct
Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor
317 6 2 3 4.5 C1=CC=C(C=C1)C2=CC=C(C=C2)CNC3=CC=C(C=C3)CC(=O)O
CHEMBL233223 ffar1_human Human No 4.9 EC50 = 12302.7 Funct
Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor
317 6 2 3 4.5 C1=CC=C(C=C1)C2=CC=C(C=C2)CNC3=CC=C(C=C3)CC(=O)O
CHEMBL597436 ffar1_human Human No 6.9 EC50 = 124 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
313 4 1 4 4.0 CC1=CC=CC=C1OC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL1777876 ffar1_human Human No 6.9 EC50 = 124 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
455 6 1 10 5.4 CC#CC(C1C(=O)NC(=O)O1)C2=CC=C(C=C2)OC3=C(C=C(C=C3)C(F)(F)F)OC(F)F
CHEMBL1777873 ffar1_mouse Mouse No 6.9 EC50 = 124 Funct
Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
272 5 1 3 3.5 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2CCCC2
CHEMBL597436 ffar1_human Human No 6.9 EC50 = 124 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
313 4 1 4 4.0 CC1=CC=CC=C1OC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL1777876 ffar1_human Human No 6.9 EC50 = 124 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
455 6 1 10 5.4 CC#CC(C1C(=O)NC(=O)O1)C2=CC=C(C=C2)OC3=C(C=C(C=C3)C(F)(F)F)OC(F)F
CHEMBL1777873 ffar1_mouse Mouse No 6.9 EC50 = 124 Funct
Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
272 5 1 3 3.5 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2CCCC2
CHEMBL1777865 ffar1_mouse Mouse No 5.9 EC50 = 1248 Funct
Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
398 5 1 6 5.9 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=CC=C(C3=CC=CC=C32)C(F)(F)F
CHEMBL1777865 ffar1_mouse Mouse No 5.9 EC50 = 1248 Funct
Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
398 5 1 6 5.9 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=CC=C(C3=CC=CC=C32)C(F)(F)F
CHEMBL2381304 ffar1_human Human No 6.9 EC50 = 125 Funct
Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay
577 9 1 9 4.5 CS(=O)(=O)CCCOC1=CC(=C(C=C1)C2=C(C=CC(=C2)C3COC4=C(O3)C=C5C(=C4)C(CO5)CC(=O)O)F)Cl
CHEMBL1773260 ffar1_human Human No 6.9 EC50 = 125.9 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
345 7 2 3 5.1 CC1=CC=C(C=C1)C2=CC(=CC=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL380719 ffar1_human Human No 6.9 EC50 = 125.9 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
361 8 2 4 5.0 CC(CC(=O)O)C1=CC=C(C=C1)NCC2=CC(=CC=C2)OC3=CC=CC=C3
CHEMBL1773260 ffar1_human Human No 6.9 EC50 = 125.9 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
345 7 2 3 5.1 CC1=CC=C(C=C1)C2=CC(=CC=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL380719 ffar1_human Human No 6.9 EC50 = 125.9 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
361 8 2 4 5.0 CC(CC(=O)O)C1=CC=C(C=C1)NCC2=CC(=CC=C2)OC3=CC=CC=C3
CHEMBL393661 ffar1_human Human No 5.9 EC50 = 1258.9 Funct
Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor
285 7 2 4 3.4 COC1=CC=C(C=C1)CNC2=CC=C(C=C2)CCC(=O)O
CHEMBL473459 ffar1_human Human Yes 5.9 EC50 = 1258.9 Funct
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay
252 5 1 3 3.5 C1=CC=C(C=C1)C#CC2=CC=C(C=C2)OCC(=O)O
CHEMBL393661 ffar1_human Human No 5.9 EC50 = 1258.9 Funct
Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor
285 7 2 4 3.4 COC1=CC=C(C=C1)CNC2=CC=C(C=C2)CCC(=O)O
CHEMBL473459 ffar1_human Human Yes 5.9 EC50 = 1258.9 Funct
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay
252 5 1 3 3.5 C1=CC=C(C=C1)C#CC2=CC=C(C=C2)OCC(=O)O
CHEMBL1773250 ffar1_human Human No 4.9 EC50 = 12589.3 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
382 6 1 3 3.8 C1=CC=C(C=C1)COC2=C(C=C(C=C2)CCC(=O)O)I
CHEMBL1773250 ffar1_human Human No 4.9 EC50 = 12589.3 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
382 6 1 3 3.8 C1=CC=C(C=C1)COC2=C(C=C(C=C2)CCC(=O)O)I
CHEMBL3601049 ffar1_human Human Yes 5.9 EC50 = 1260 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
403 7 1 6 3.8 C1=CC(=CC(=C1)Br)C2=NOC(=N2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3601049 ffar1_human Human Yes 5.9 EC50 = 1260 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
403 7 1 6 3.8 C1=CC(=CC(=C1)Br)C2=NOC(=N2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL1777860 ffar1_mouse Mouse No 6.9 EC50 = 127 Funct
Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
362 5 1 6 5.0 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=C(C=C(C=C2)C(F)(F)F)C
CHEMBL1777860 ffar1_mouse Mouse No 6.9 EC50 = 127 Funct
Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
362 5 1 6 5.0 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=C(C=C(C=C2)C(F)(F)F)C
CHEMBL3265147 ffar1_human Human No 6.9 EC50 = 128 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
518 8 1 6 7.7 CC1(CCCC1C2=C(C=CC(=C2)COC3=CC4=C(CCC4(C)CC(=O)O)C=C3)C5=CC(=NC=C5F)OC)C
CHEMBL3265147 ffar1_human Human No 6.9 EC50 = 128 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
518 8 1 6 7.7 CC1(CCCC1C2=C(C=CC(=C2)COC3=CC4=C(CCC4(C)CC(=O)O)C=C3)C5=CC(=NC=C5F)OC)C
CHEMBL3805879 ffar1_human Human No 5.9 EC50 = 1280 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay
371 6 2 7 3.1 C1=CC(=CC(=C1)NC(=O)C2=NN=C(S2)CCC(=O)O)C3=CC=C(C=C3)F
CHEMBL3805879 ffar1_human Human No 5.9 EC50 = 1280 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay
371 6 2 7 3.1 C1=CC(=CC(=C1)NC(=O)C2=NN=C(S2)CCC(=O)O)C3=CC=C(C=C3)F
CHEMBL1829173 ffar1_human Human Yes 7.9 EC50 = 13 Funct
Agonist activity at FFA1 (unknown origin)Agonist activity at FFA1 (unknown origin)
438 7 1 6 6.2 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC(=C2)C3=CC=C(C=C3)C(F)(F)F
CHEMBL1829173 ffar1_human Human Yes 7.9 EC50 = 13 Funct
Agonist activity at GPR40 (unknown origin) by calcium flux assayAgonist activity at GPR40 (unknown origin) by calcium flux assay
438 7 1 6 6.2 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC(=C2)C3=CC=C(C=C3)C(F)(F)F
CHEMBL2152070 ffar1_human Human Yes 7.9 EC50 = 13 Funct
Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin
515 10 1 5 7.8 CC1(CCC=C1C2=C(C=CC(=C2)COC3=CC=CC(=C3)C(CC(=O)O)C4CC4)C5=C(C=CC(=C5)OC)F)C
CHEMBL2047157 ffar1_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
567 9 2 8 4.1 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)OCC5(CCS(=O)(=O)CC5)O
CHEMBL3603843 ffar1_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
394 7 1 7 4.2 CCOC(CC(=O)O)C1=CC=C(C=C1)OC2CCC3=C2C=CC(=C3)C(F)(F)F
CHEMBL3604057 ffar1_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
386 8 1 8 3.9 CCOC(CC(=O)O)C1=CC=C(C=C1)OCC2=C(C=C(C=C2)C(F)(F)F)F
CHEMBL3604063 ffar1_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
366 8 1 4 4.3 CCOC(CC(=O)O)C1=CC=C(C=C1)OC2CCC3=C(C=CC=C23)C4CC4
CHEMBL3604052 ffar1_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
368 8 1 5 4.3 CCOC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=C(C3=CC=CC=C23)F
CHEMBL207881 ffar1_human Human Yes 7.9 EC50 = 13 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay
347 8 2 4 4.7 C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL2048617 ffar1_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
449 12 1 5 5.7 CCOCCOC1=CC(=C(C(=C1)C)C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O)C
CHEMBL1829173 ffar1_mouse Mouse Yes 7.9 EC50 = 13 Funct
Agonist activity at mouse GPR40Agonist activity at mouse GPR40
438 7 1 6 6.2 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC(=C2)C3=CC=C(C=C3)C(F)(F)F
CHEMBL1829173 ffar1_human Human Yes 7.9 EC50 = 13 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis
438 7 1 6 6.2 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC(=C2)C3=CC=C(C=C3)C(F)(F)F
CHEMBL2152070 ffar1_human Human Yes 7.9 EC50 = 13 Funct
Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin
515 10 1 5 7.8 CC1(CCC=C1C2=C(C=CC(=C2)COC3=CC=CC(=C3)C(CC(=O)O)C4CC4)C5=C(C=CC(=C5)OC)F)C
CHEMBL2047157 ffar1_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
567 9 2 8 4.1 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)OCC5(CCS(=O)(=O)CC5)O
CHEMBL3603843 ffar1_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
394 7 1 7 4.2 CCOC(CC(=O)O)C1=CC=C(C=C1)OC2CCC3=C2C=CC(=C3)C(F)(F)F
CHEMBL3604057 ffar1_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
386 8 1 8 3.9 CCOC(CC(=O)O)C1=CC=C(C=C1)OCC2=C(C=C(C=C2)C(F)(F)F)F
CHEMBL3604063 ffar1_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
366 8 1 4 4.3 CCOC(CC(=O)O)C1=CC=C(C=C1)OC2CCC3=C(C=CC=C23)C4CC4
CHEMBL3604052 ffar1_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
368 8 1 5 4.3 CCOC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=C(C3=CC=CC=C23)F
CHEMBL207881 ffar1_human Human Yes 7.9 EC50 = 13 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay
347 8 2 4 4.7 C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL2048617 ffar1_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
449 12 1 5 5.7 CCOCCOC1=CC(=C(C(=C1)C)C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O)C
CHEMBL1829173 ffar1_mouse Mouse Yes 7.9 EC50 = 13 Funct
Agonist activity at mouse GPR40Agonist activity at mouse GPR40
438 7 1 6 6.2 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC(=C2)C3=CC=C(C=C3)C(F)(F)F
CHEMBL1829173 ffar1_human Human Yes 7.9 EC50 = 13 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis
438 7 1 6 6.2 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC(=C2)C3=CC=C(C=C3)C(F)(F)F
CHEMBL207753 ffar1_human Human No 7.9 EC50 = 13.5 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
359 7 2 4 4.6 C1C(C1C(=O)O)C2=CC=C(C=C2)NCC3=CC(=CC=C3)OC4=CC=CC=C4
CHEMBL2381282 ffar1_human Human No 7.9 EC50 = 13.5 Funct
Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay
391 3 1 5 3.2 C1C(C2=CC3=C(C=C2O1)OC(CO3)C4=CC(=CC=C4)Br)CC(=O)O
CHEMBL1777878 ffar1_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
455 6 1 10 5.4 CC#CC(C1C(=O)NC(=O)O1)C2=CC=C(C=C2)OC3=C(C=C(C=C3)C(F)(F)F)OC(F)F
CHEMBL3288350 ffar1_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay
362 7 1 5 4.1 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=NC=C(C=N3)CCC(=O)O
CHEMBL3288351 ffar1_rat Rat No 6.9 EC50 = 130 Funct
Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay
375 7 1 4 5.1 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=NC=C(C(=C3)C)CCC(=O)O
CHEMBL3288359 ffar1_rat Rat No 6.9 EC50 = 130 Funct
Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay
405 9 1 5 4.6 CCOC(CC(=O)O)C1=CN=C(C=C1)OCC2=CC=CC(=C2)C3=C(C=CC=C3C)C
CHEMBL3754486 ffar1_human Human No 6.9 EC50 = 130 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis
480 8 1 7 5.2 CN1C=CN=C1C(CC(=O)O)C2=CC=C(C=C2)OCC3=CC=CC(=C3)C4=CC=C(C=C4)C(F)(F)F
CHEMBL2152070 ffar1_human Human Yes 6.9 EC50 = 130 Funct
Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay
515 10 1 5 7.8 CC1(CCC=C1C2=C(C=CC(=C2)COC3=CC=CC(=C3)C(CC(=O)O)C4CC4)C5=C(C=CC(=C5)OC)F)C
CHEMBL1777878 ffar1_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
455 6 1 10 5.4 CC#CC(C1C(=O)NC(=O)O1)C2=CC=C(C=C2)OC3=C(C=C(C=C3)C(F)(F)F)OC(F)F
CHEMBL3288350 ffar1_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay
362 7 1 5 4.1 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=NC=C(C=N3)CCC(=O)O
CHEMBL3288351 ffar1_rat Rat No 6.9 EC50 = 130 Funct
Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay
375 7 1 4 5.1 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=NC=C(C(=C3)C)CCC(=O)O
CHEMBL3288359 ffar1_rat Rat No 6.9 EC50 = 130 Funct
Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay
405 9 1 5 4.6 CCOC(CC(=O)O)C1=CN=C(C=C1)OCC2=CC=CC(=C2)C3=C(C=CC=C3C)C
CHEMBL3754486 ffar1_human Human No 6.9 EC50 = 130 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis
480 8 1 7 5.2 CN1C=CN=C1C(CC(=O)O)C2=CC=C(C=C2)OCC3=CC=CC(=C3)C4=CC=C(C=C4)C(F)(F)F
CHEMBL2151300 ffar1_human Human No 5.9 EC50 = 1310 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
505 10 1 5 8.5 CC(C)(C)C1=C(C=CC(=C1)COC2=CC=CC(=C2)C(CC(=O)O)C3CCCC3)C4=C(C=CC(=C4)OC)F
CHEMBL3330549 ffar1_human Human No 5.9 EC50 = 1310 Funct
Modulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assayModulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assay
529 8 1 9 7.4 CCC1C(N(N=C1C(F)(F)F)C2=CC=C(C=C2)CC3=C(C=C(C=C3)C4=C(C=CC(=C4)OC)F)C)CC(=O)O
CHEMBL2151300 ffar1_human Human No 5.9 EC50 = 1310 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
505 10 1 5 8.5 CC(C)(C)C1=C(C=CC(=C1)COC2=CC=CC(=C2)C(CC(=O)O)C3CCCC3)C4=C(C=CC(=C4)OC)F
CHEMBL3601058 ffar1_human Human Yes 4.9 EC50 = 13100 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
359 7 1 6 3.7 C1=CC=C(C=C1)C2=NOC(=N2)COC3=C(C=C(C=C3)CCC(=O)O)Cl
CHEMBL3601058 ffar1_human Human Yes 4.9 EC50 = 13100 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
359 7 1 6 3.7 C1=CC=C(C=C1)C2=NOC(=N2)COC3=C(C=C(C=C3)CCC(=O)O)Cl
CHEMBL1829143 ffar1_human Human No 4.9 EC50 = 13182.6 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
251 5 1 3 2.7 C1=CC=NC(=C1)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL1829143 ffar1_human Human No 4.9 EC50 = 13182.6 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
251 5 1 3 2.7 C1=CC=NC(=C1)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL2381316 ffar1_human Human No 6.9 EC50 = 132 Funct
Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay
416 4 1 5 4.8 CC1=CC(=CC(=C1)C2=CC(=CC=C2)C3COC4=C(O3)C=C5C(=C4)C(CO5)CC(=O)O)C
CHEMBL3616719 ffar1_human Human No 6.9 EC50 = 132.9 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method
361 7 2 6 3.6 CC1=C(C=C(C=C1)OC(C)C(=O)NC2=CC(=C(C=C2)OCC(=O)O)F)C
CHEMBL3616719 ffar1_human Human No 6.9 EC50 = 132.9 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method
361 7 2 6 3.6 CC1=C(C=C(C=C1)OC(C)C(=O)NC2=CC(=C(C=C2)OCC(=O)O)F)C
CHEMBL1829166 ffar1_human Human No 6.9 EC50 = 134.9 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
300 5 1 3 4.0 CC1=C(C=CN=C1Cl)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL1688457 ffar1_human Human No 6.9 EC50 = 134.9 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
332 7 1 3 4.8 C1=CC=C(C=C1)C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL1829166 ffar1_human Human No 6.9 EC50 = 134.9 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
300 5 1 3 4.0 CC1=C(C=CN=C1Cl)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL1688457 ffar1_human Human No 6.9 EC50 = 134.9 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
332 7 1 3 4.8 C1=CC=C(C=C1)C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL609615 ffar1_human Human No 6.9 EC50 = 135 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
349 4 1 4 4.8 C1=CC=C2C(=C1)C=CC=C2OC3=CC=C(C=C3)CC4C(=O)NC(=O)S4
CHEMBL609615 ffar1_human Human No 6.9 EC50 = 135 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
349 4 1 4 4.8 C1=CC=C2C(=C1)C=CC=C2OC3=CC=C(C=C3)CC4C(=O)NC(=O)S4
CHEMBL3616652 ffar1_human Human No 6.9 EC50 = 135.3 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method
333 7 2 6 2.9 CC(C(=O)NC1=CC(=C(C=C1)OCC(=O)O)F)OC2=CC=CC=C2
CHEMBL3616652 ffar1_human Human No 6.9 EC50 = 135.3 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method
333 7 2 6 2.9 CC(C(=O)NC1=CC(=C(C=C1)OCC(=O)O)F)OC2=CC=CC=C2
CHEMBL3616656 ffar1_human Human No 6.9 EC50 = 135.9 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method
351 7 2 7 3.0 CC(C(=O)NC1=CC(=C(C=C1)OCC(=O)O)F)OC2=CC=CC=C2F
CHEMBL3616656 ffar1_human Human No 6.9 EC50 = 135.9 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method
351 7 2 7 3.0 CC(C(=O)NC1=CC(=C(C=C1)OCC(=O)O)F)OC2=CC=CC=C2F
CHEMBL1777856 ffar1_human Human Yes 5.9 EC50 = 1358 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
311 5 1 3 4.5 C1=CC(=CC=C1CCC(=O)O)OC2=C(C=C(C=C2)Cl)Cl
CHEMBL1777856 ffar1_human Human Yes 5.9 EC50 = 1358 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
311 5 1 3 4.5 C1=CC(=CC=C1CCC(=O)O)OC2=C(C=C(C=C2)Cl)Cl
CHEMBL1777878 ffar1_mouse Mouse No 6.9 EC50 = 136 Funct
Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
455 6 1 10 5.4 CC#CC(C1C(=O)NC(=O)O1)C2=CC=C(C=C2)OC3=C(C=C(C=C3)C(F)(F)F)OC(F)F
CHEMBL1777878 ffar1_mouse Mouse No 6.9 EC50 = 136 Funct
Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
455 6 1 10 5.4 CC#CC(C1C(=O)NC(=O)O1)C2=CC=C(C=C2)OC3=C(C=C(C=C3)C(F)(F)F)OC(F)F
CHEMBL3780713 ffar1_human Human No 6.9 EC50 = 137.5 Funct
Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay
416 6 1 6 4.4 CC1=C(SC(=N1)C2=CC(=CC=C2)Cl)COC3=CC4=C(C=C3)C(CO4)CC(=O)O
CHEMBL3780713 ffar1_human Human No 6.9 EC50 = 137.5 Funct
Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay
416 6 1 6 4.4 CC1=C(SC(=N1)C2=CC(=CC=C2)Cl)COC3=CC4=C(C=C3)C(CO4)CC(=O)O
CHEMBL2315543 ffar1_human Human No 6.9 EC50 = 138.0 Funct
Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis
299 5 1 2 4.7 CC1=C(C=CC(=C1)Cl)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL2315538 ffar1_human Human No 6.9 EC50 = 138.0 Funct
Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis
276 4 1 2 4.0 CC1=CC=CC=C1C#CC2=CC=C(C=C2)C3CC3C(=O)O
CHEMBL2385471 ffar1_human Human No 5.9 EC50 = 1380 Funct
Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay
487 8 1 5 6.9 CC1(CCC=C1C2=C(C=CC(=C2)COC3=CC=CC(=C3)C4CC4C(=O)O)C5=C(C=CC(=C5)OC)F)C
CHEMBL598732 ffar1_human Human No 4.9 EC50 = 13850 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
433 5 1 9 4.3 COC1=C(C=CC(=C1)OC2=C(C=C(C=N2)C(F)(F)F)Cl)CC3C(=O)NC(=O)S3
CHEMBL598732 ffar1_human Human No 4.9 EC50 = 13850 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
433 5 1 9 4.3 COC1=C(C=CC(=C1)OC2=C(C=C(C=N2)C(F)(F)F)Cl)CC3C(=O)NC(=O)S3
CHEMBL2047158 ffar1_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
525 11 1 7 4.8 CCS(=O)(=O)CCOC1=CC(=C(C(=C1)C)C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C
CHEMBL3288359 ffar1_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay
405 9 1 5 4.6 CCOC(CC(=O)O)C1=CN=C(C=C1)OCC2=CC=CC(=C2)C3=C(C=CC=C3C)C
CHEMBL2048616 ffar1_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
467 10 1 4 7.0 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O)C)OCC4=CC=CC=C4
CHEMBL2047158 ffar1_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
525 11 1 7 4.8 CCS(=O)(=O)CCOC1=CC(=C(C(=C1)C)C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C
CHEMBL3288359 ffar1_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay
405 9 1 5 4.6 CCOC(CC(=O)O)C1=CN=C(C=C1)OCC2=CC=CC(=C2)C3=C(C=CC=C3C)C
CHEMBL2048616 ffar1_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
467 10 1 4 7.0 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O)C)OCC4=CC=CC=C4
CHEMBL2164242 ffar1_human Human Yes 7.9 EC50 = 14.1 Funct
Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay
500 12 2 7 5.0 CC1=C(C=CC(=C1)OCCCS(=O)(=O)C)C2=CC(=CC=C2)CNC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL380884 ffar1_human Human No 7.9 EC50 = 14.1 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
474 7 2 7 5.7 CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)CNC3=CC=C(C=C3)C4CC4C(=O)NC(C)C
CHEMBL2164242 ffar1_human Human Yes 7.9 EC50 = 14.1 Funct
Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay
500 12 2 7 5.0 CC1=C(C=CC(=C1)OCCCS(=O)(=O)C)C2=CC(=CC=C2)CNC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL380884 ffar1_human Human No 7.9 EC50 = 14.1 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
474 7 2 7 5.7 CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)CNC3=CC=C(C=C3)C4CC4C(=O)NC(C)C
CHEMBL1773261 ffar1_human Human No 7.8 EC50 = 14.8 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay in presence of 0.05 % bovine serum albuminAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay in presence of 0.05 % bovine serum albumin
345 7 2 3 5.1 CC1=CC=CC=C1C2=CC(=CC=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL203297 ffar1_human Human No 7.8 EC50 = 14.8 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
374 7 3 4 3.9 C1C(C1C(=O)NO)C2=CC=C(C=C2)NCC3=CC(=CC=C3)OC4=CC=CC=C4
CHEMBL1773261 ffar1_human Human No 7.8 EC50 = 14.8 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay in presence of 0.05 % bovine serum albuminAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay in presence of 0.05 % bovine serum albumin
345 7 2 3 5.1 CC1=CC=CC=C1C2=CC(=CC=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL2163925 ffar1_human Human No 7.8 EC50 = 14.8 Funct
Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.05% BSAAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.05% BSA
496 12 2 6 5.2 CC1=CC(=CC(=C1C2=CC(=CC=C2)CNC3=CC=C(C=C3)CCC(=O)O)C)OCCCS(=O)(=O)C
CHEMBL203297 ffar1_human Human No 7.8 EC50 = 14.8 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
374 7 3 4 3.9 C1C(C1C(=O)NO)C2=CC=C(C=C2)NCC3=CC(=CC=C3)OC4=CC=CC=C4
CHEMBL2022580 ffar1_human Human No 6.9 EC50 = 140 Funct
Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA
475 10 1 5 6.1 CCOCCOC1=CC(=C(C(=C1)C)C2=CC(=CC=C2)COC3=CC4=C(CC(CC4)C(=O)O)C=C3)C
CHEMBL2022580 ffar1_human Human No 6.9 EC50 = 140 Funct
Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA
475 10 1 5 6.1 CCOCCOC1=CC(=C(C(=C1)C)C2=CC(=CC=C2)COC3=CC4=C(CC(CC4)C(=O)O)C=C3)C
CHEMBL3616663 ffar1_human Human No 6.9 EC50 = 140.3 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method
389 8 2 6 4.5 CC(C(=O)NC1=CC(=C(C=C1)OCC(=O)O)F)OC2=CC=CC(=C2)C(C)(C)C
CHEMBL3616663 ffar1_human Human No 6.9 EC50 = 140.3 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method
389 8 2 6 4.5 CC(C(=O)NC1=CC(=C(C=C1)OCC(=O)O)F)OC2=CC=CC(=C2)C(C)(C)C
CHEMBL3288350 ffar1_rat Rat No 5.9 EC50 = 1400 Funct
Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay
362 7 1 5 4.1 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=NC=C(C=N3)CCC(=O)O
CHEMBL3288350 ffar1_rat Rat No 5.9 EC50 = 1400 Funct
Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay
362 7 1 5 4.1 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=NC=C(C=N3)CCC(=O)O
CHEMBL1777865 ffar1_human Human No 5.9 EC50 = 1401 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
398 5 1 6 5.9 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=CC=C(C3=CC=CC=C32)C(F)(F)F
CHEMBL1777865 ffar1_human Human No 5.9 EC50 = 1401 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
398 5 1 6 5.9 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=CC=C(C3=CC=CC=C32)C(F)(F)F
CHEMBL598731 ffar1_human Human No 5.9 EC50 = 1407 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
398 5 1 5 4.8 COC1=C(C=CC(=C1)OC2=C(C=C(C=C2)Cl)Cl)CC3C(=O)NC(=O)S3
CHEMBL598731 ffar1_human Human No 5.9 EC50 = 1407 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
398 5 1 5 4.8 COC1=C(C=CC(=C1)OC2=C(C=C(C=C2)Cl)Cl)CC3C(=O)NC(=O)S3
CHEMBL2386360 ffar1_human Human No 6.9 EC50 = 141.3 Funct
Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay
286 5 1 4 3.9 C1=CC=C(C=C1)C#CC2=CC(=C(C(=C2)F)CCC(=O)O)F
CHEMBL3265143 ffar1_human Human No 5.9 EC50 = 1410 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
521 12 1 6 7.2 CC(C)(C)C(C1=C(C=CC(=C1)COC2=CC=CC(=C2)C(CC(=O)O)C3CC3)C4=C(C=CC(=C4)OC)F)OC
CHEMBL3265143 ffar1_human Human No 5.9 EC50 = 1410 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
521 12 1 6 7.2 CC(C)(C)C(C1=C(C=CC(=C1)COC2=CC=CC(=C2)C(CC(=O)O)C3CC3)C4=C(C=CC(=C4)OC)F)OC
CHEMBL2385466 ffar1_human Human No 5.9 EC50 = 1420 Funct
Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay
499 7 1 5 6.8 CC1(CCC=C1C2=C(C=CC(=C2)COC3=CC4=C(CC5C4C5C(=O)O)C=C3)C6=C(C=CC(=C6)OC)F)C
CHEMBL3800255 ffar1_human Human No 6.8 EC50 = 143 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
441 10 1 7 5.4 CC1=C(C(=NO1)C)C2=CC(=CC(=C2)OCC(C)C)COC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL3800255 ffar1_human Human No 6.9 EC50 = 143 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
441 10 1 7 5.4 CC1=C(C(=NO1)C)C2=CC(=CC(=C2)OCC(C)C)COC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL601420 ffar1_human Human No 6.8 EC50 = 144 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
350 4 1 5 4.1 C1=CC=C2C=NC(=CC2=C1)OC3=CC=C(C=C3)CC4C(=O)NC(=O)S4
CHEMBL601420 ffar1_human Human No 6.8 EC50 = 144 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
350 4 1 5 4.1 C1=CC=C2C=NC(=CC2=C1)OC3=CC=C(C=C3)CC4C(=O)NC(=O)S4
CHEMBL205960 ffar1_human Human No 6.8 EC50 = 144.5 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
345 7 2 4 4.9 C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)C=CC(=O)O
CHEMBL2315537 ffar1_human Human No 6.8 EC50 = 144.5 Funct
Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis
262 4 1 2 3.7 C1C(C1C(=O)O)C2=CC=C(C=C2)C#CC3=CC=CC=C3
CHEMBL2386358 ffar1_human Human No 6.8 EC50 = 144.5 Funct
Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay
268 5 1 3 3.8 C1=CC=C(C=C1)C#CC2=C(C=C(C=C2)CCC(=O)O)F
CHEMBL205960 ffar1_human Human No 6.8 EC50 = 144.5 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
345 7 2 4 4.9 C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)C=CC(=O)O
CHEMBL3785789 ffar1_human Human No 5.8 EC50 = 1445.4 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay
272 9 1 2 5.6 CCCCCCCC#CC1=CC=C(C=C1)CCC(=O)O
CHEMBL3785789 ffar1_human Human No 5.8 EC50 = 1445.4 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay
272 9 1 2 5.6 CCCCCCCC#CC1=CC=C(C=C1)CCC(=O)O
CHEMBL2386366 ffar1_human Human No 5.8 EC50 = 1445.4 Funct
Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay
360 7 1 5 3.0 CS(=O)(=O)CC1=CC=CC=C1C#CC2=CC(=C(C=C2)CCC(=O)O)F
CHEMBL2381300 ffar1_human Human No 6.8 EC50 = 145.2 Funct
Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay
559 9 1 8 4.4 CS(=O)(=O)CCCOC1=CC(=C(C=C1)C2=CC(=CC=C2)C3COC4=C(O3)C=C5C(=C4)C(CO5)CC(=O)O)Cl
CHEMBL252528 ffar1_human Human Yes 4.8 EC50 = 14500 Funct
Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay
283 7 2 4 3.5 C=CCOC1=CC=C(C=C1)CNC2=CC=CC(=C2)C(=O)O
CHEMBL252528 ffar1_human Human Yes 4.8 EC50 = 14500 Funct
Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay
283 7 2 4 3.5 C=CCOC1=CC=C(C=C1)CNC2=CC=CC(=C2)C(=O)O
CHEMBL3265140 ffar1_human Human No 6.8 EC50 = 147 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
521 12 1 6 7.2 CC(C)(C)C(C1=C(C=CC(=C1)COC2=CC=CC(=C2)C(CC(=O)O)C3CC3)C4=C(C=CC(=C4)OC)F)OC
CHEMBL3604056 ffar1_human Human No 6.8 EC50 = 147 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
369 8 1 4 4.2 CCOC(CC(=O)O)C1=CC(=CC=C1)OCC2=CC(=C(C=C2)Cl)Cl
CHEMBL3265140 ffar1_human Human No 6.8 EC50 = 147 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
521 12 1 6 7.2 CC(C)(C)C(C1=C(C=CC(=C1)COC2=CC=CC(=C2)C(CC(=O)O)C3CC3)C4=C(C=CC(=C4)OC)F)OC
CHEMBL3604056 ffar1_human Human No 6.8 EC50 = 147 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
369 8 1 4 4.2 CCOC(CC(=O)O)C1=CC(=CC=C1)OCC2=CC(=C(C=C2)Cl)Cl
CHEMBL3616479 ffar1_human Human No 6.8 EC50 = 147.6 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method
349 8 2 7 2.4 COC1=CC(=CC=C1)OCC(=O)NC2=CC(=C(C=C2)OCC(=O)O)F
CHEMBL3616479 ffar1_human Human No 6.8 EC50 = 147.6 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method
349 8 2 7 2.4 COC1=CC(=CC=C1)OCC(=O)NC2=CC(=C(C=C2)OCC(=O)O)F
CHEMBL2386353 ffar1_mouse Mouse Yes 6.8 EC50 = 147.9 Funct
Agonist activity at mouse FFA1 receptor transfected in human T-REX-293 cells measured for 74 secs by calcium mobilization assayAgonist activity at mouse FFA1 receptor transfected in human T-REX-293 cells measured for 74 secs by calcium mobilization assay
307 6 1 4 3.5 C1=CC=C(C(=C1)CC#N)C#CC2=CC(=C(C=C2)CCC(=O)O)F
CHEMBL3616658 ffar1_human Human No 6.8 EC50 = 148.2 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method
333 7 2 6 2.8 CC1=CC=C(C=C1)OCC(=O)NC2=CC(=C(C=C2)OCC(=O)O)F
CHEMBL3616658 ffar1_human Human No 6.8 EC50 = 148.2 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method
333 7 2 6 2.8 CC1=CC=C(C=C1)OCC(=O)NC2=CC(=C(C=C2)OCC(=O)O)F
CHEMBL1777867 ffar1_mouse Mouse No 5.8 EC50 = 1484 Funct
Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
361 5 1 5 3.1 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=NC=C(C=N2)Br
CHEMBL1777867 ffar1_mouse Mouse No 5.8 EC50 = 1484 Funct
Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
361 5 1 5 3.1 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=NC=C(C=N2)Br
CHEMBL1777869 ffar1_mouse Mouse No 6.8 EC50 = 149 Funct
Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
331 5 1 4 4.3 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=NC=CC3=CC=CC=C32
CHEMBL1777869 ffar1_mouse Mouse No 6.8 EC50 = 149 Funct
Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
331 5 1 4 4.3 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=NC=CC3=CC=CC=C32
CHEMBL2048615 ffar1_human Human No 7.8 EC50 = 15 Funct
Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
431 10 1 4 6.2 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O)C)OCC4CC4
CHEMBL2048624 ffar1_human Human No 7.8 EC50 = 15 Funct
Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
557 10 2 8 4.6 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC(=C(C=C3)CCC(=O)O)F)C)OCC4(CCS(=O)(=O)CC4)O
CHEMBL2048615 ffar1_human Human No 7.8 EC50 = 15 Funct
Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
431 10 1 4 6.2 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O)C)OCC4CC4
CHEMBL2048624 ffar1_human Human No 7.8 EC50 = 15 Funct
Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
557 10 2 8 4.6 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC(=C(C=C3)CCC(=O)O)F)C)OCC4(CCS(=O)(=O)CC4)O
CHEMBL3799274 ffar1_human Human No 7.8 EC50 = 15.9 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
404 7 1 6 4.7 CC1=C(C(=NO1)C)C2=C(C=CC(=C2)COC3=CC(=C(C=C3)CCC(=O)O)F)Cl
CHEMBL3799274 ffar1_human Human No 7.8 EC50 = 15.9 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
404 7 1 6 4.7 CC1=C(C(=NO1)C)C2=C(C=CC(=C2)COC3=CC(=C(C=C3)CCC(=O)O)F)Cl
CHEMBL3265145 ffar1_human Human No 6.8 EC50 = 150 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
507 10 1 7 6.9 CCC(CC(=O)O)C1=CC(=NC=C1)OCC2=CC(=C(C=C2)C3=CC(=NC=C3F)OC)C4CCCC4(C)C
CHEMBL3265145 ffar1_human Human No 6.8 EC50 = 150 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
507 10 1 7 6.9 CCC(CC(=O)O)C1=CC(=NC=C1)OCC2=CC(=C(C=C2)C3=CC(=NC=C3F)OC)C4CCCC4(C)C
CHEMBL2385473 ffar1_human Human No 6.8 EC50 = 150 Funct
Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay
527 7 1 5 8.0 CC1(CCC=C1C2=C(C=CC(=C2)COC3=CC4=C(CCCC45CC5C(=O)O)C=C3)C6=C(C=CC(=C6)OC)F)C
CHEMBL3604035 ffar1_human Human No 5.8 EC50 = 1500 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
383 8 1 4 4.6 CCOC(CC(=O)O)C1=CC(=C(C=C1)OCC2=CC(=C(C=C2)Cl)Cl)C
CHEMBL3604035 ffar1_human Human No 5.8 EC50 = 1500 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
383 8 1 4 4.6 CCOC(CC(=O)O)C1=CC(=C(C=C1)OCC2=CC(=C(C=C2)Cl)Cl)C
CHEMBL2315547 ffar1_human Human No 6.8 EC50 = 151.4 Funct
Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis
285 5 1 2 4.3 C1=CC=C(C(=C1)C#CC2=CC=C(C=C2)CCC(=O)O)Cl
CHEMBL252330 ffar1_human Human Yes 4.8 EC50 = 15100 Funct
Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay
405 8 1 8 4.5 COC1=CC=C(C=C1)CSC2=NN=C(S2)SCC3=CC=C(C=C3)C(=O)O
CHEMBL252330 ffar1_human Human Yes 4.8 EC50 = 15100 Funct
Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay
405 8 1 8 4.5 COC1=CC=C(C=C1)CSC2=NN=C(S2)SCC3=CC=C(C=C3)C(=O)O
CHEMBL3805668 ffar1_human Human No 5.8 EC50 = 1520 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay
397 8 2 7 3.2 CC1=CC=CC=C1NC(=O)C2=NN=C(S2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3805668 ffar1_human Human No 5.8 EC50 = 1520 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay
397 8 2 7 3.2 CC1=CC=CC=C1NC(=O)C2=NN=C(S2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3353738 ffar1_human Human No 6.8 EC50 = 153.3 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assay
513 12 1 7 5.4 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC(=C(C=C3)OCC(=O)O)C)C)OCCCS(=O)(=O)C
CHEMBL3353738 ffar1_human Human No 6.8 EC50 = 153.3 Funct
Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assay
513 12 1 7 5.4 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC(=C(C=C3)OCC(=O)O)C)C)OCCCS(=O)(=O)C
CHEMBL1688454 ffar1_human Human No 6.8 EC50 = 154.9 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
348 8 1 4 4.7 C1=CC=C(C=C1)OC2=CC=C(C=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL1829173 ffar1_human Human Yes 6.8 EC50 = 154.9 Funct
Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay
438 7 1 6 6.2 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC(=C2)C3=CC=C(C=C3)C(F)(F)F
CHEMBL487570 ffar1_human Human No 6.8 EC50 = 154.9 Funct
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay
274 6 1 2 3.9 C#CC1=CC(=CC=C1)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL1688454 ffar1_human Human No 6.8 EC50 = 154.9 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
348 8 1 4 4.7 C1=CC=C(C=C1)OC2=CC=C(C=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL1829173 ffar1_human Human Yes 6.8 EC50 = 154.9 Funct
Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay
438 7 1 6 6.2 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC(=C2)C3=CC=C(C=C3)C(F)(F)F
CHEMBL487570 ffar1_human Human No 6.8 EC50 = 154.9 Funct
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay
274 6 1 2 3.9 C#CC1=CC(=CC=C1)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL1777867 ffar1_human Human No 5.8 EC50 = 1568 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
361 5 1 5 3.1 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=NC=C(C=N2)Br
CHEMBL1777867 ffar1_human Human No 5.8 EC50 = 1568 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
361 5 1 5 3.1 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=NC=C(C=N2)Br
CHEMBL1777868 ffar1_human Human No 5.8 EC50 = 1578 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
307 5 1 6 2.0 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=NC=CN=C2C#N
CHEMBL1777868 ffar1_human Human No 5.8 EC50 = 1578 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
307 5 1 6 2.0 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=NC=CN=C2C#N
CHEMBL397776 ffar1_human Human No 5.8 EC50 = 1584.9 Funct
Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor
345 8 2 3 5.1 C1=CC=C(C=C1)C2=CC=C(C=C2)CNC3=CC=C(C=C3)CCCC(=O)O
CHEMBL397776 ffar1_human Human No 5.8 EC50 = 1584.9 Funct
Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor
345 8 2 3 5.1 C1=CC=C(C=C1)C2=CC=C(C=C2)CNC3=CC=C(C=C3)CCCC(=O)O
CHEMBL2047149 ffar1_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
477 11 1 6 5.2 CCOCCOC1=CC(=C(C(=C1)C)C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C
CHEMBL2047168 ffar1_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
543 11 1 8 4.8 CC1=CC(=C(C(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)F)OCCCS(=O)(=O)C
CHEMBL2047169 ffar1_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
559 11 1 7 5.4 CC1=CC(=C(C(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)Cl)OCCCS(=O)(=O)C
CHEMBL3286409 ffar1_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay
502 8 1 9 4.7 CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)COC3=CC=C(C=C3)C(CC(=O)O)C4=NC=CN4C
CHEMBL3288348 ffar1_rat Rat No 7.8 EC50 = 16 Funct
Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay
362 7 1 5 3.7 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=NC=C(N=C3)CCC(=O)O
CHEMBL2047149 ffar1_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
477 11 1 6 5.2 CCOCCOC1=CC(=C(C(=C1)C)C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C
CHEMBL2047168 ffar1_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
543 11 1 8 4.8 CC1=CC(=C(C(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)F)OCCCS(=O)(=O)C
CHEMBL2047169 ffar1_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
559 11 1 7 5.4 CC1=CC(=C(C(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)Cl)OCCCS(=O)(=O)C
CHEMBL3286409 ffar1_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay
502 8 1 9 4.7 CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)COC3=CC=C(C=C3)C(CC(=O)O)C4=NC=CN4C
CHEMBL2381287 ffar1_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay
381 3 1 5 3.7 C1C(C2=CC3=C(C=C2O1)OC(CO3)C4=CC(=C(C=C4)Cl)Cl)CC(=O)O
CHEMBL3288348 ffar1_rat Rat No 7.8 EC50 = 16 Funct
Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay
362 7 1 5 3.7 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=NC=C(N=C3)CCC(=O)O
CHEMBL1688465 ffar1_human Human No 7.8 EC50 = 16.6 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
346 7 1 3 5.1 CC1=CC=CC=C1C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL1688465 ffar1_human Human No 7.8 EC50 = 16.6 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
346 7 1 3 5.1 CC1=CC=CC=C1C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL2386363 ffar1_human Human No 7.8 EC50 = 17.0 Funct
Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay
307 5 1 4 3.9 CC1=C(C=C(C=C1)C#N)C#CC2=CC(=C(C=C2)CCC(=O)O)F
CHEMBL3600994 ffar1_human Human No 6.8 EC50 = 160 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
358 7 1 5 3.9 C1=CC(=CC(=C1)Cl)C2=NC(=CO2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL2152070 ffar1_human Human Yes 6.8 EC50 = 160 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay
515 10 1 5 7.8 CC1(CCC=C1C2=C(C=CC(=C2)COC3=CC=CC(=C3)C(CC(=O)O)C4CC4)C5=C(C=CC(=C5)OC)F)C
CHEMBL2152070 ffar1_human Human Yes 6.8 EC50 = 160 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
515 10 1 5 7.8 CC1(CCC=C1C2=C(C=CC(=C2)COC3=CC=CC(=C3)C(CC(=O)O)C4CC4)C5=C(C=CC(=C5)OC)F)C
CHEMBL3600994 ffar1_human Human No 6.8 EC50 = 160 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
358 7 1 5 3.9 C1=CC(=CC(=C1)Cl)C2=NC(=CO2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL2152070 ffar1_human Human Yes 6.8 EC50 = 160 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
515 10 1 5 7.8 CC1(CCC=C1C2=C(C=CC(=C2)COC3=CC=CC(=C3)C(CC(=O)O)C4CC4)C5=C(C=CC(=C5)OC)F)C
CHEMBL2152070 ffar1_human Human Yes 6.8 EC50 = 160 Funct
Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay
515 10 1 5 7.8 CC1(CCC=C1C2=C(C=CC(=C2)COC3=CC=CC(=C3)C(CC(=O)O)C4CC4)C5=C(C=CC(=C5)OC)F)C
CHEMBL3600998 ffar1_human Human Yes 5.8 EC50 = 1600 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
323 7 1 5 3.3 C1=CC=C(C=C1)C2=CN=C(O2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3604032 ffar1_human Human No 5.8 EC50 = 1600 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
327 7 2 4 2.7 CCOC(CC(=O)O)C1=CC=C(C=C1)NC(=O)C2=CC=CC=C2C
CHEMBL3600998 ffar1_human Human Yes 5.8 EC50 = 1600 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
323 7 1 5 3.3 C1=CC=C(C=C1)C2=CN=C(O2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3604032 ffar1_human Human No 5.8 EC50 = 1600 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
327 7 2 4 2.7 CCOC(CC(=O)O)C1=CC=C(C=C1)NC(=O)C2=CC=CC=C2C
CHEMBL2152070 ffar1_human Human Yes 6.8 EC50 = 161 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
515 10 1 5 7.8 CC1(CCC=C1C2=C(C=CC(=C2)COC3=CC=CC(=C3)C(CC(=O)O)C4CC4)C5=C(C=CC(=C5)OC)F)C
CHEMBL2152070 ffar1_human Human Yes 6.8 EC50 = 161 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
515 10 1 5 7.8 CC1(CCC=C1C2=C(C=CC(=C2)COC3=CC=CC(=C3)C(CC(=O)O)C4CC4)C5=C(C=CC(=C5)OC)F)C
CHEMBL404008 ffar1_human Human Yes 4.8 EC50 = 16100 Funct
Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay
345 5 2 4 3.5 C1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)C(=O)NC3=CC=C(C=C3)C(=O)O
CHEMBL404008 ffar1_human Human Yes 4.8 EC50 = 16100 Funct
Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay
345 5 2 4 3.5 C1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)C(=O)NC3=CC=C(C=C3)C(=O)O
CHEMBL3265149 ffar1_human Human No 6.8 EC50 = 162 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
523 12 1 8 5.7 CC(C)(C)C(C1=C(C=CC(=C1)COC2=NC=CC(=C2)C(CC(=O)O)C3CC3)C4=CC(=NC=C4F)OC)OC
CHEMBL3265149 ffar1_human Human No 6.8 EC50 = 162 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
523 12 1 8 5.7 CC(C)(C)C(C1=C(C=CC(=C1)COC2=NC=CC(=C2)C(CC(=O)O)C3CC3)C4=CC(=NC=C4F)OC)OC
CHEMBL2315550 ffar1_human Human No 4.8 EC50 = 16218.1 Funct
Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis
266 5 2 3 3.3 C1=CC=C(C(=C1)C#CC2=CC=C(C=C2)CCC(=O)O)O
CHEMBL606213 ffar1_human Human No 5.8 EC50 = 1635 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
368 4 1 8 3.8 C1=CC(=NC(=C1)OC2=CC=C(C=C2)CC3C(=O)NC(=O)S3)C(F)(F)F
CHEMBL606213 ffar1_human Human No 5.8 EC50 = 1635 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
368 4 1 8 3.8 C1=CC(=NC(=C1)OC2=CC=C(C=C2)CC3C(=O)NC(=O)S3)C(F)(F)F
CHEMBL3805303 ffar1_human Human No 5.8 EC50 = 1640 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay
343 6 2 7 2.1 C1=CC(=CC(=C1)NC(=O)C2=NN=C(S2)CCC(=O)O)C3=CC=CO3
CHEMBL3805303 ffar1_human Human No 5.8 EC50 = 1640 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay
343 6 2 7 2.1 C1=CC(=CC(=C1)NC(=O)C2=NN=C(S2)CCC(=O)O)C3=CC=CO3
CHEMBL1773252 ffar1_human Human Yes 6.8 EC50 = 166.0 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
335 6 1 3 4.1 C1=CC(=CC=C1CCC(=O)O)OCC2=CC=C(C=C2)Br
CHEMBL1773252 ffar1_human Human Yes 6.8 EC50 = 166.0 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
335 6 1 3 4.1 C1=CC(=CC=C1CCC(=O)O)OCC2=CC=C(C=C2)Br
CHEMBL234268 ffar1_human Human No 4.8 EC50 = 16595.9 Funct
Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor
347 7 2 4 5.0 CC(C1=CC=C(C=C1)NCC2=CC(=CC=C2)OC3=CC=CC=C3)C(=O)O
CHEMBL234268 ffar1_human Human No 4.8 EC50 = 16595.9 Funct
Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor
347 7 2 4 5.0 CC(C1=CC=C(C=C1)NCC2=CC(=CC=C2)OC3=CC=CC=C3)C(=O)O
CHEMBL3758719 ffar1_human Human No 5.8 EC50 = 1660 Funct
Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay
502 9 1 5 6.8 C1=CC=C(C=C1)C(CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3)OC4=C(C=C(C=C4)Cl)Cl
CHEMBL3758719 ffar1_human Human No 5.8 EC50 = 1660 Funct
Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay
502 9 1 5 6.8 C1=CC=C(C=C1)C(CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3)OC4=C(C=C(C=C4)Cl)Cl
CHEMBL3759448 ffar1_human Human No 4.8 EC50 = 16600 Funct
Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay
395 6 1 5 3.8 CC(C)N1C2=CC=CC=C2N=C1COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4
CHEMBL3759448 ffar1_human Human No 4.8 EC50 = 16600 Funct
Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay
395 6 1 5 3.8 CC(C)N1C2=CC=CC=C2N=C1COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4
CHEMBL252526 ffar1_human Human Yes 4.8 EC50 = 16700 Funct
Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay
312 7 0 7 3.5 COC(=O)CSC1=NN=C(S1)SCC2=CC=CC=C2
CHEMBL252526 ffar1_human Human Yes 4.8 EC50 = 16700 Funct
Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay
312 7 0 7 3.5 COC(=O)CSC1=NN=C(S1)SCC2=CC=CC=C2
CHEMBL402053 ffar1_human Human Yes 4.8 EC50 = 16800 Funct
Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay
297 5 1 6 1.9 C1=COC(=C1)C=C2C(=O)N(C(=S)S2)CCCC(=O)O
CHEMBL402053 ffar1_human Human Yes 4.8 EC50 = 16800 Funct
Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay
297 5 1 6 1.9 C1=COC(=C1)C=C2C(=O)N(C(=S)S2)CCCC(=O)O
CHEMBL1829173 ffar1_human Human Yes 6.8 EC50 = 169.8 Funct
Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay
438 7 1 6 6.2 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC(=C2)C3=CC=C(C=C3)C(F)(F)F
CHEMBL1829173 ffar1_human Human Yes 6.8 EC50 = 169.8 Funct
Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay
438 7 1 6 6.2 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC(=C2)C3=CC=C(C=C3)C(F)(F)F
CHEMBL3805558 ffar1_human Human No 5.8 EC50 = 1690 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay
388 6 2 6 3.6 C1=CC(=CC(=C1)NC(=O)C2=NN=C(S2)CCC(=O)O)C3=CC(=CC=C3)Cl
CHEMBL3805558 ffar1_human Human No 5.8 EC50 = 1690 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay
388 6 2 6 3.6 C1=CC(=CC(=C1)NC(=O)C2=NN=C(S2)CCC(=O)O)C3=CC(=CC=C3)Cl
CHEMBL2047164 ffar1_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
553 13 1 7 5.6 CCC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)CC)OCCCS(=O)(=O)C
CHEMBL2047170 ffar1_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
594 11 1 7 6.0 CC1=C(C(=C(C(=C1Cl)OCCCS(=O)(=O)C)Cl)C)C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O
CHEMBL2047163 ffar1_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
535 9 1 6 6.4 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)OCC5=CC=CC6=NC=CN65
CHEMBL2047160 ffar1_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
530 11 1 6 4.9 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)OCCCN5CCCC5=O
CHEMBL2047164 ffar1_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
553 13 1 7 5.6 CCC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)CC)OCCCS(=O)(=O)C
CHEMBL2047170 ffar1_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
594 11 1 7 6.0 CC1=C(C(=C(C(=C1Cl)OCCCS(=O)(=O)C)Cl)C)C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O
CHEMBL2047163 ffar1_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
535 9 1 6 6.4 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)OCC5=CC=CC6=NC=CN65
CHEMBL2047160 ffar1_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
530 11 1 6 4.9 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)OCCCN5CCCC5=O
CHEMBL2163924 ffar1_human Human No 7.8 EC50 = 17.4 Funct
Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.05% BSAAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.05% BSA
482 12 2 6 4.9 CC1=C(C=CC(=C1)OCCCS(=O)(=O)C)C2=CC(=CC=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL2164241 ffar1_human Human No 7.8 EC50 = 17.8 Funct
Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilizationAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization
377 7 2 4 5.6 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)CNC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL1688470 ffar1_human Human No 6.8 EC50 = 170 Funct
Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA
378 7 1 4 6.0 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=CC=C(C=C3)CC(C(=O)O)F
CHEMBL1688471 ffar1_human Human No 6.8 EC50 = 170 Funct
Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA
374 7 1 3 6.1 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=CC=C(C=C3)CC(C)C(=O)O
CHEMBL1688470 ffar1_human Human No 6.8 EC50 = 170 Funct
Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA
378 7 1 4 6.0 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=CC=C(C=C3)CC(C(=O)O)F
CHEMBL1688471 ffar1_human Human No 6.8 EC50 = 170 Funct
Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA
374 7 1 3 6.1 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=CC=C(C=C3)CC(C)C(=O)O
CHEMBL1688491 ffar1_human Human No 5.8 EC50 = 1700 Funct
Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA
298 9 1 3 4.3 C1=CC=C(C=C1)CCCCOC2=CC=C(C=C2)CCC(=O)O
CHEMBL3604029 ffar1_human Human No 5.8 EC50 = 1700 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
338 8 1 5 3.3 CCOC(CC1=NNN=N1)C2=CC=C(C=C2)OCC3=CC=CC=C3C
CHEMBL1688491 ffar1_human Human No 5.8 EC50 = 1700 Funct
Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA
298 9 1 3 4.3 C1=CC=C(C=C1)CCCCOC2=CC=C(C=C2)CCC(=O)O
CHEMBL2022246 ffar1_human Human No 5.8 EC50 = 1700 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAAgonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA
386 6 1 4 5.6 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(=CO4)CC(=O)O
CHEMBL3604029 ffar1_human Human No 5.8 EC50 = 1700 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
338 8 1 5 3.3 CCOC(CC1=NNN=N1)C2=CC=C(C=C2)OCC3=CC=CC=C3C
CHEMBL1777864 ffar1_human Human No 6.8 EC50 = 172 Funct
Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serumAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serum
355 5 1 4 4.8 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=CC=C(C3=CC=CC=C32)C#N
CHEMBL1777864 ffar1_human Human No 6.8 EC50 = 172 Funct
Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serumAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serum
355 5 1 4 4.8 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=CC=C(C3=CC=CC=C32)C#N
CHEMBL394666 ffar1_human Human No 6.8 EC50 = 173.8 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
334 6 2 3 3.8 C1=CC(=CC(=C1)Br)CNC2=CC=C(C=C2)CCC(=O)O
CHEMBL206779 ffar1_human Human No 6.8 EC50 = 173.8 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
374 8 1 3 4.6 CN(C)C(=O)CCC1=CC=C(C=C1)NCC2=CC(=CC=C2)OC3=CC=CC=C3
CHEMBL394666 ffar1_human Human No 6.8 EC50 = 173.8 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
334 6 2 3 3.8 C1=CC(=CC(=C1)Br)CNC2=CC=C(C=C2)CCC(=O)O
CHEMBL206779 ffar1_human Human No 6.8 EC50 = 173.8 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
374 8 1 3 4.6 CN(C)C(=O)CCC1=CC=C(C=C1)NCC2=CC(=CC=C2)OC3=CC=CC=C3
CHEMBL1829164 ffar1_human Human No 6.8 EC50 = 177.8 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
283 5 1 4 3.4 CC1=CN=C(C=C1C#CC2=CC=C(C=C2)CCC(=O)O)F
CHEMBL604126 ffar1_human Human No 6.8 EC50 = 177.8 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
417 4 1 8 4.7 CC1=C(C=CC(=C1)OC2=C(C=C(C=N2)C(F)(F)F)Cl)CC3C(=O)NC(=O)S3
CHEMBL1829164 ffar1_human Human No 6.8 EC50 = 177.8 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
283 5 1 4 3.4 CC1=CN=C(C=C1C#CC2=CC=C(C=C2)CCC(=O)O)F
CHEMBL604126 ffar1_human Human No 6.8 EC50 = 177.8 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
417 4 1 8 4.7 CC1=C(C=CC(=C1)OC2=C(C=C(C=N2)C(F)(F)F)Cl)CC3C(=O)NC(=O)S3
CHEMBL3806055 ffar1_human Human No 5.8 EC50 = 1770 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay
397 8 2 7 3.2 CC1=CC(=CC=C1)NC(=O)C2=NN=C(S2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3806055 ffar1_human Human No 5.8 EC50 = 1770 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay
397 8 2 7 3.2 CC1=CC(=CC=C1)NC(=O)C2=NN=C(S2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL207881 ffar1_human Human Yes 4.8 EC50 = 17800 Funct
Agonist activity at human GPR40 N244A mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 N244A mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calcium
347 8 2 4 4.7 C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL207881 ffar1_human Human Yes 4.8 EC50 = 17800 Funct
Agonist activity at human GPR40 N244A mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 N244A mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calcium
347 8 2 4 4.7 C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL3804883 ffar1_human Human No 4.8 EC50 = 17940 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay
383 8 2 7 2.8 C1=CC=C(C=C1)COC2=CC=C(C=C2)NC(=O)C3=NN=C(S3)CCC(=O)O
CHEMBL3804883 ffar1_human Human No 4.8 EC50 = 17940 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay
383 8 2 7 2.8 C1=CC=C(C=C1)COC2=CC=C(C=C2)NC(=O)C3=NN=C(S3)CCC(=O)O
CHEMBL2047166 ffar1_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
553 11 1 7 5.5 CC1=C(C(=C(C(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)C)OCCCS(=O)(=O)C)C
CHEMBL2047152 ffar1_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
489 9 1 6 5.3 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)OCC5(COC5)C
CHEMBL2047162 ffar1_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
530 9 1 7 6.4 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)OCC5=C(N=C(S5)C)C
CHEMBL600799 ffar1_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
416 4 1 7 5.5 CC1=C(C=CC(=C1)OC2=C(C=C(C=C2)C(F)(F)F)Cl)CC3C(=O)NC(=O)S3
CHEMBL3288357 ffar1_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay
379 7 1 5 4.7 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=NC=C(C=C3)C(CC(=O)O)F
CHEMBL1688486 ffar1_rat Rat No 7.8 EC50 = 18 Funct
Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay
360 7 1 3 5.5 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL2047166 ffar1_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
553 11 1 7 5.5 CC1=C(C(=C(C(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)C)OCCCS(=O)(=O)C)C
CHEMBL2047152 ffar1_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
489 9 1 6 5.3 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)OCC5(COC5)C
CHEMBL2047162 ffar1_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
530 9 1 7 6.4 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)OCC5=C(N=C(S5)C)C
CHEMBL600799 ffar1_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
416 4 1 7 5.5 CC1=C(C=CC(=C1)OC2=C(C=C(C=C2)C(F)(F)F)Cl)CC3C(=O)NC(=O)S3
CHEMBL3288357 ffar1_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay
379 7 1 5 4.7 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=NC=C(C=C3)C(CC(=O)O)F
CHEMBL1688486 ffar1_rat Rat No 7.8 EC50 = 18 Funct
Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay
360 7 1 3 5.5 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL2386364 ffar1_human Human No 7.7 EC50 = 18.2 Funct
Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay
336 6 1 6 4.5 C1=CC(=C(C=C1C#CC2=C(C=CC(=C2)F)C(F)F)F)CCC(=O)O
CHEMBL2386355 ffar1_human Human No 7.7 EC50 = 18.2 Funct
Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay
321 7 1 4 3.8 C1=CC=C(C(=C1)CCC#N)C#CC2=CC(=C(C=C2)CCC(=O)O)F
CHEMBL2386353 ffar1_human Human Yes 7.7 EC50 = 18.6 Funct
Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay
307 6 1 4 3.5 C1=CC=C(C(=C1)CC#N)C#CC2=CC(=C(C=C2)CCC(=O)O)F
CHEMBL1773261 ffar1_human Human No 7.7 EC50 = 18.6 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
345 7 2 3 5.1 CC1=CC=CC=C1C2=CC(=CC=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL1773261 ffar1_human Human No 7.7 EC50 = 18.6 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
345 7 2 3 5.1 CC1=CC=CC=C1C2=CC(=CC=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL2386353 ffar1_human Human Yes 7.7 EC50 = 18.6 Funct
Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay
307 6 1 4 3.5 C1=CC=C(C(=C1)CC#N)C#CC2=CC(=C(C=C2)CCC(=O)O)F
CHEMBL1773261 ffar1_human Human No 7.7 EC50 = 18.6 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
345 7 2 3 5.1 CC1=CC=CC=C1C2=CC(=CC=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL1773261 ffar1_human Human No 7.7 EC50 = 18.6 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
345 7 2 3 5.1 CC1=CC=CC=C1C2=CC(=CC=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL1773261 ffar1_human Human No 7.7 EC50 = 18.6 Funct
Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilizationAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization
345 7 2 3 5.1 CC1=CC=CC=C1C2=CC(=CC=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL1939648 ffar1_human Human No 6.8 EC50 = 180 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay
308 6 1 3 4.1 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=C(C=C2)C
CHEMBL2022254 ffar1_human Human No 6.8 EC50 = 180 Funct
Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA
416 6 1 5 5.3 C1C(C2=C(O1)C=C(C=C2)OCC3=CC=CC(=C3)C4=CC5=C(C=C4)SC=C5)CC(=O)O
CHEMBL2385470 ffar1_human Human No 6.8 EC50 = 180 Funct
Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay
513 7 1 5 7.4 CC1(CCC=C1C2=C(C=CC(=C2)COC3=CC4=C(CCC45CC5C(=O)O)C=C3)C6=C(C=CC(=C6)OC)F)C
CHEMBL1939648 ffar1_human Human No 6.8 EC50 = 180 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay
308 6 1 3 4.1 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=C(C=C2)C
CHEMBL2022254 ffar1_human Human No 6.8 EC50 = 180 Funct
Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA
416 6 1 5 5.3 C1C(C2=C(O1)C=C(C=C2)OCC3=CC=CC(=C3)C4=CC5=C(C=C4)SC=C5)CC(=O)O
CHEMBL251963 ffar1_human Human Yes 5.8 EC50 = 1800 Funct
Activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayActivity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay
348 6 1 7 4.4 C1=CC=C2C(=C1)C=CC=C2CSC3=NN=C(S3)SCC(=O)O
CHEMBL1688469 ffar1_human Human No 5.8 EC50 = 1800 Funct
Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA
377 7 1 3 6.0 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)CSC3=CC=C(C=C3)CCC(=O)O
CHEMBL251963 ffar1_human Human Yes 5.8 EC50 = 1800 Funct
Activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayActivity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay
348 6 1 7 4.4 C1=CC=C2C(=C1)C=CC=C2CSC3=NN=C(S3)SCC(=O)O
CHEMBL1688469 ffar1_human Human No 5.8 EC50 = 1800 Funct
Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA
377 7 1 3 6.0 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)CSC3=CC=C(C=C3)CCC(=O)O
CHEMBL234057 ffar1_human Human No 6.7 EC50 = 182.0 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
347 8 2 4 4.7 C1=CC=C(C=C1)OC2=CC=C(C=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL2164242 ffar1_rat Rat Yes 6.7 EC50 = 182.0 Funct
Agonist activity at GPR40 in rat INS-1E cells assessed as receptor activation by dynamic mass redistribution assayAgonist activity at GPR40 in rat INS-1E cells assessed as receptor activation by dynamic mass redistribution assay
500 12 2 7 5.0 CC1=C(C=CC(=C1)OCCCS(=O)(=O)C)C2=CC(=CC=C2)CNC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL234057 ffar1_human Human No 6.7 EC50 = 182.0 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
347 8 2 4 4.7 C1=CC=C(C=C1)OC2=CC=C(C=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL3787151 ffar1_human Human No 5.7 EC50 = 1819.7 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay
278 6 1 2 4.3 C1=CC=C(C=C1)CCC#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL3787151 ffar1_human Human No 5.7 EC50 = 1819.7 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay
278 6 1 2 4.3 C1=CC=C(C=C1)CCC#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL1829162 ffar1_human Human No 6.7 EC50 = 186.2 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
327 6 1 3 4.3 C1=CC=C(C=C1)C2=NC=CC(=C2)C#CC3=CC=C(C=C3)CCC(=O)O
CHEMBL1773256 ffar1_human Human No 6.7 EC50 = 186.2 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
323 6 2 6 4.0 C1=CC(=CC(=C1)C(F)(F)F)CNC2=CC=C(C=C2)CCC(=O)O
CHEMBL2315248 ffar1_human Human No 6.7 EC50 = 186.2 Funct
Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis
292 6 1 3 3.4 CC(=O)C1=CC=CC=C1C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL1829162 ffar1_human Human No 6.7 EC50 = 186.2 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
327 6 1 3 4.3 C1=CC=C(C=C1)C2=NC=CC(=C2)C#CC3=CC=C(C=C3)CCC(=O)O
CHEMBL1773256 ffar1_human Human No 6.7 EC50 = 186.2 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
323 6 2 6 4.0 C1=CC(=CC(=C1)C(F)(F)F)CNC2=CC=C(C=C2)CCC(=O)O
CHEMBL3817889 ffar1_human Human No 6.7 EC50 = 187 Funct
Agonist activity at eYFP-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at eYFP-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay
631 15 2 12 5.8 CC1=C(C=CC(=C1)OCCOCCNC2=CC=C(C3=NON=C23)[N+](=O)[O-])C4=CC(=CC=C4)COC5=CC(=C(C=C5)CCC(=O)O)F
CHEMBL3817889 ffar1_human Human No 6.7 EC50 = 187 Funct
Agonist activity at eYFP-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at eYFP-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay
631 15 2 12 5.8 CC1=C(C=CC(=C1)OCCOCCNC2=CC=C(C3=NON=C23)[N+](=O)[O-])C4=CC(=CC=C4)COC5=CC(=C(C=C5)CCC(=O)O)F
CHEMBL601850 ffar1_human Human No 5.7 EC50 = 1872 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
335 4 1 5 3.5 C1=CC(=CC=C1CC2C(=O)NC(=O)S2)OC3=NC=C(C=C3)Cl
CHEMBL601850 ffar1_human Human No 5.7 EC50 = 1872 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
335 4 1 5 3.5 C1=CC(=CC=C1CC2C(=O)NC(=O)S2)OC3=NC=C(C=C3)Cl
CHEMBL3601061 ffar1_human Human Yes 4.7 EC50 = 18800 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
345 6 1 6 3.4 C1=CC(=CC(=C1)Cl)C2=NOC(=N2)COC3=CC=C(C=C3)CC(=O)O
CHEMBL3601061 ffar1_human Human Yes 4.7 EC50 = 18800 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
345 6 1 6 3.4 C1=CC(=CC(=C1)Cl)C2=NOC(=N2)COC3=CC=C(C=C3)CC(=O)O
CHEMBL3758197 ffar1_human Human No 5.7 EC50 = 1890 Funct
Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay
410 7 1 5 4.3 CC(C)CN1C2=CC=CC=C2N=C1COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4
CHEMBL3758197 ffar1_human Human No 5.7 EC50 = 1890 Funct
Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay
410 7 1 5 4.3 CC(C)CN1C2=CC=CC=C2N=C1COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4
CHEMBL1773261 ffar1_mouse Mouse No 7.7 EC50 = 19 Funct
Activation of FFA1 in mouse islets assessed as glucose-dependent insulin secretionActivation of FFA1 in mouse islets assessed as glucose-dependent insulin secretion
345 7 2 3 5.1 CC1=CC=CC=C1C2=CC(=CC=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL1688487 ffar1_human Human No 7.7 EC50 = 19 Funct
Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA
360 7 1 3 5.5 CC1=CC=CC(=C1C)C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL474195 ffar1_human Human No 7.7 EC50 = 19 Funct
Agonist activity at GPR40Agonist activity at GPR40
549 13 1 6 7.2 C1=CC=C(C=C1)C2=CSC(=N2)C(CCC3=CC=CC=N3)CC4=CC=C(C=C4)COC5=CC=C(C=C5)CCC(=O)O
CHEMBL3265146 ffar1_human Human No 7.7 EC50 = 19 Funct
Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin
493 9 1 7 6.3 CC(CC(=O)O)C1=CC(=NC=C1)OCC2=CC(=C(C=C2)C3=CC(=NC=C3F)OC)C4CCCC4(C)C
CHEMBL2047167 ffar1_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
555 8 1 8 5.0 CC1=CC(=C(C(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)F)OC5CCS(=O)(=O)CC5
CHEMBL3427713 ffar1_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay
394 7 1 7 4.2 CCOC(CC(=O)O)C1=CC=C(C=C1)OC2CCC3=C2C=CC=C3C(F)(F)F
CHEMBL3604041 ffar1_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
335 8 1 4 3.6 CCOC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC(=CC=C2)Cl
CHEMBL1773261 ffar1_mouse Mouse No 7.7 EC50 = 19 Funct
Activation of FFA1 in mouse islets assessed as glucose-dependent insulin secretionActivation of FFA1 in mouse islets assessed as glucose-dependent insulin secretion
345 7 2 3 5.1 CC1=CC=CC=C1C2=CC(=CC=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL1688487 ffar1_human Human No 7.7 EC50 = 19 Funct
Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA
360 7 1 3 5.5 CC1=CC=CC(=C1C)C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL474195 ffar1_human Human No 7.7 EC50 = 19 Funct
Agonist activity at GPR40Agonist activity at GPR40
549 13 1 6 7.2 C1=CC=C(C=C1)C2=CSC(=N2)C(CCC3=CC=CC=N3)CC4=CC=C(C=C4)COC5=CC=C(C=C5)CCC(=O)O
CHEMBL3265146 ffar1_human Human No 7.7 EC50 = 19 Funct
Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin
493 9 1 7 6.3 CC(CC(=O)O)C1=CC(=NC=C1)OCC2=CC(=C(C=C2)C3=CC(=NC=C3F)OC)C4CCCC4(C)C
CHEMBL2047167 ffar1_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
555 8 1 8 5.0 CC1=CC(=C(C(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)F)OC5CCS(=O)(=O)CC5
CHEMBL3427713 ffar1_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay
394 7 1 7 4.2 CCOC(CC(=O)O)C1=CC=C(C=C1)OC2CCC3=C2C=CC=C3C(F)(F)F
CHEMBL3604041 ffar1_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
335 8 1 4 3.6 CCOC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC(=CC=C2)Cl
CHEMBL2381308 ffar1_human Human No 7.7 EC50 = 19.1 Funct
Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay
402 4 1 5 4.5 CC1=CC=CC=C1C2=CC(=CC=C2)C3COC4=C(O3)C=C5C(=C4)C(CO5)CC(=O)O
CHEMBL2315528 ffar1_human Human No 7.7 EC50 = 20.0 Funct
Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay
289 6 1 3 3.4 C1=CC=C(C(=C1)CC#N)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL3604064 ffar1_human Human No 6.7 EC50 = 190 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
356 8 1 5 3.3 CCOC(CC(=O)O)C1=CC=C(C=C1)OC2CCC3=C2C=CC=C3OC
CHEMBL3288360 ffar1_rat Rat No 6.7 EC50 = 190 Funct
Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay
389 6 1 5 3.8 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=NC=C4C(OCC4=C3)CC(=O)O
CHEMBL3330548 ffar1_human Human No 6.7 EC50 = 190 Funct
Modulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assayModulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assay
484 7 1 9 6.0 CC1=C(C=CC(=C1)C2=CC(=CC=C2)OC)OC3=CC=C(C=C3)N4C(CC(=N4)C(F)(F)F)CC(=O)O
CHEMBL3752557 ffar1_human Human No 6.7 EC50 = 190 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis
477 8 1 7 6.0 C1=CC(=CC(=C1)COC2=CC=C(C=C2)C(CC(=O)O)C3=CC=NC=C3)C4=CC=C(C=C4)C(F)(F)F
CHEMBL3753088 ffar1_human Human No 6.7 EC50 = 190 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis
483 8 1 7 6.8 C1=CC(=CC(=C1)COC2=CC=C(C=C2)C(CC(=O)O)C3=CC=CS3)C4=CC=C(C=C4)C(F)(F)F
CHEMBL3604064 ffar1_human Human No 6.7 EC50 = 190 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
356 8 1 5 3.3 CCOC(CC(=O)O)C1=CC=C(C=C1)OC2CCC3=C2C=CC=C3OC
CHEMBL3288360 ffar1_rat Rat No 6.7 EC50 = 190 Funct
Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay
389 6 1 5 3.8 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=NC=C4C(OCC4=C3)CC(=O)O
CHEMBL3330548 ffar1_human Human No 6.7 EC50 = 190 Funct
Modulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assayModulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assay
484 7 1 9 6.0 CC1=C(C=CC(=C1)C2=CC(=CC=C2)OC)OC3=CC=C(C=C3)N4C(CC(=N4)C(F)(F)F)CC(=O)O
CHEMBL3752557 ffar1_human Human No 6.7 EC50 = 190 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis
477 8 1 7 6.0 C1=CC(=CC(=C1)COC2=CC=C(C=C2)C(CC(=O)O)C3=CC=NC=C3)C4=CC=C(C=C4)C(F)(F)F
CHEMBL3753088 ffar1_human Human No 6.7 EC50 = 190 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis
483 8 1 7 6.8 C1=CC(=CC(=C1)COC2=CC=C(C=C2)C(CC(=O)O)C3=CC=CS3)C4=CC=C(C=C4)C(F)(F)F
CHEMBL2381288 ffar1_human Human No 6.7 EC50 = 190.5 Funct
Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay
381 3 1 5 3.7 C1C(C2=CC3=C(C=C2O1)OC(CO3)C4=CC(=C(C=C4)Cl)Cl)CC(=O)O
CHEMBL2315529 ffar1_human Human No 6.7 EC50 = 190.6 Funct
Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis
289 6 1 3 3.4 C1=CC(=CC(=C1)CC#N)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL2151291 ffar1_human Human No 5.7 EC50 = 1900 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
380 8 1 5 4.8 COC1=CC(=C(C=C1)F)C2=CC=C(C=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL2151298 ffar1_human Human No 5.7 EC50 = 1900 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serum
477 10 1 5 7.4 CC(C)(C)C1=C(C=CC(=C1)COC2=CC=CC(=C2)C(CC(=O)O)C3CC3)C4=C(C=CC(=C4)OC)F
CHEMBL2151291 ffar1_human Human No 5.7 EC50 = 1900 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
380 8 1 5 4.8 COC1=CC(=C(C=C1)F)C2=CC=C(C=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL2151298 ffar1_human Human No 5.7 EC50 = 1900 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serum
477 10 1 5 7.4 CC(C)(C)C1=C(C=CC(=C1)COC2=CC=CC(=C2)C(CC(=O)O)C3CC3)C4=C(C=CC(=C4)OC)F
CHEMBL255071 ffar1_human Human Yes 4.7 EC50 = 19000 Funct
Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay
313 5 1 6 2.5 C1=CSC(=C1)C=C2C(=O)N(C(=S)S2)CCCC(=O)O
CHEMBL463785 ffar1_human Human Yes 4.7 EC50 = 19000 Funct
Agonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay
376 10 1 5 4.6 C1=CC=C(C=C1)N(CCOC2=CC=C(C=C2)CCCC(=O)O)C3=CC=CC=N3
CHEMBL255071 ffar1_human Human Yes 4.7 EC50 = 19000 Funct
Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay
313 5 1 6 2.5 C1=CSC(=C1)C=C2C(=O)N(C(=S)S2)CCCC(=O)O
CHEMBL463785 ffar1_human Human Yes 4.7 EC50 = 19000 Funct
Agonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay
376 10 1 5 4.6 C1=CC=C(C=C1)N(CCOC2=CC=C(C=C2)CCCC(=O)O)C3=CC=CC=N3
CHEMBL1688455 ffar1_human Human Yes 5.7 EC50 = 1905.5 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
332 7 1 3 4.8 C1=CC=C(C=C1)C2=CC=CC=C2COC3=CC=C(C=C3)CCC(=O)O
CHEMBL1688455 ffar1_human Human Yes 5.7 EC50 = 1905.5 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
332 7 1 3 4.8 C1=CC=C(C=C1)C2=CC=CC=C2COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3797836 ffar1_human Human No 5.7 EC50 = 1930 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
370 7 1 7 3.1 CC1=C(C(=NO1)C)C2=CC(=NC=C2)COC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL3797836 ffar1_human Human No 5.7 EC50 = 1930 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
370 7 1 7 3.1 CC1=C(C(=NO1)C)C2=CC(=NC=C2)COC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL234057 ffar1_human Human No 6.7 EC50 = 195.0 Funct
Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor
347 8 2 4 4.7 C1=CC=C(C=C1)OC2=CC=C(C=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL234057 ffar1_human Human No 6.7 EC50 = 195.0 Funct
Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor
347 8 2 4 4.7 C1=CC=C(C=C1)OC2=CC=C(C=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL2386367 ffar1_human Human No 5.7 EC50 = 1949.8 Funct
Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay
360 7 1 5 3.0 CS(=O)(=O)CC1=CC=CC(=C1)C#CC2=CC(=C(C=C2)CCC(=O)O)F
CHEMBL2164242 ffar1_human Human Yes 5.7 EC50 = 1949.8 Funct
Agonist activity at human GPR40 expressed in HEK293 cells assessed as receptor activation in presence of 30 uM FFA1 antagonist TUG-761 by dynamic mass redistribution assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as receptor activation in presence of 30 uM FFA1 antagonist TUG-761 by dynamic mass redistribution assay
500 12 2 7 5.0 CC1=C(C=CC(=C1)OCCCS(=O)(=O)C)C2=CC(=CC=C2)CNC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL3759866 ffar1_human Human No 4.7 EC50 = 19580 Funct
Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay
464 10 1 6 5.6 COC1=CC(=CC=C1)OC(CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3)C4=CC=CC=C4
CHEMBL3759866 ffar1_human Human No 4.7 EC50 = 19580 Funct
Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay
464 10 1 6 5.6 COC1=CC(=CC=C1)OC(CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3)C4=CC=CC=C4
CHEMBL1773256 ffar1_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
323 6 2 6 4.0 C1=CC(=CC(=C1)C(F)(F)F)CNC2=CC=C(C=C2)CCC(=O)O
CHEMBL488384 ffar1_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
250 5 1 2 3.9 C1=CC=C(C=C1)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL3786524 ffar1_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay
254 5 1 2 3.8 C1CCC(=CC1)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL488384 ffar1_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay
250 5 1 2 3.9 C1=CC=C(C=C1)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL488384 ffar1_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
250 5 1 2 3.9 C1=CC=C(C=C1)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL1773256 ffar1_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
323 6 2 6 4.0 C1=CC(=CC(=C1)C(F)(F)F)CNC2=CC=C(C=C2)CCC(=O)O
CHEMBL2315535 ffar1_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis
264 5 1 2 4.2 CC(CC(=O)O)C1=CC=C(C=C1)C#CC2=CC=CC=C2
CHEMBL488384 ffar1_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry
250 5 1 2 3.9 C1=CC=C(C=C1)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL3786524 ffar1_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay
254 5 1 2 3.8 C1CCC(=CC1)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL488384 ffar1_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay
250 5 1 2 3.9 C1=CC=C(C=C1)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL488384 ffar1_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay
250 5 1 2 3.9 C1=CC=C(C=C1)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL488384 ffar1_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
250 5 1 2 3.9 C1=CC=C(C=C1)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL234468 ffar1_human Human No 5.7 EC50 = 1995.3 Funct
Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor
323 6 2 6 4.0 C1=CC(=CC=C1CCC(=O)O)NCC2=CC=C(C=C2)C(F)(F)F
CHEMBL394900 ffar1_human Human No 5.7 EC50 = 1995.3 Funct
Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor
296 6 2 4 3.8 C1=CC(=CC=C1CCC(=O)O)NCC2=CC=C(S2)Cl
CHEMBL234468 ffar1_human Human No 5.7 EC50 = 1995.3 Funct
Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor
323 6 2 6 4.0 C1=CC(=CC=C1CCC(=O)O)NCC2=CC=C(C=C2)C(F)(F)F
CHEMBL394900 ffar1_human Human No 5.7 EC50 = 1995.3 Funct
Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor
296 6 2 4 3.8 C1=CC(=CC=C1CCC(=O)O)NCC2=CC=C(S2)Cl
CHEMBL1829173 ffar1_human Human Yes 8.7 EC50 = 2.2 Funct
Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay
438 7 1 6 6.2 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC(=C2)C3=CC=C(C=C3)C(F)(F)F
CHEMBL382381 ffar1_human Human No 8.6 EC50 = 2.5 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
432 6 2 8 5.1 CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)CNC3=CC=C(C=C3)C4CC4C(=O)O
CHEMBL1688484 ffar1_human Human No 7.7 EC50 = 20 Funct
Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA
367 7 1 3 5.4 C1=CC=C(C(=C1)C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O)Cl
CHEMBL3785637 ffar1_human Human No 7.7 EC50 = 20 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay
246 5 1 3 3.8 CC=C(C)C#CC1=CC(=C(C=C1)CCC(=O)O)F
CHEMBL3288362 ffar1_human Human Yes 7.7 EC50 = 20 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay
314 8 1 4 3.3 CCOC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC=C2C
CHEMBL3288362 ffar1_human Human Yes 7.7 EC50 = 20 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
314 8 1 4 3.3 CCOC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC=C2C
CHEMBL3604067 ffar1_human Human No 7.7 EC50 = 20 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
395 7 1 8 3.5 CCOC(CC(=O)O)C1=CN=C(C=C1)OC2CCC3=C2C=CC=C3C(F)(F)F
CHEMBL3288362 ffar1_human Human Yes 7.7 EC50 = 20 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay
314 8 1 4 3.3 CCOC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC=C2C
CHEMBL2048613 ffar1_human Human No 7.7 EC50 = 20 Funct
Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
390 8 1 4 5.5 CC1=C(C(=CC=C1)C)C2=C(C=CC(=C2)COC3=CC=C(C=C3)CCC(=O)O)OC
CHEMBL3330549 ffar1_human Human No 7.7 EC50 = 20 Funct
Modulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assayModulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assay
529 8 1 9 7.4 CCC1C(N(N=C1C(F)(F)F)C2=CC=C(C=C2)CC3=C(C=C(C=C3)C4=C(C=CC(=C4)OC)F)C)CC(=O)O
CHEMBL1688484 ffar1_human Human No 7.7 EC50 = 20 Funct
Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA
367 7 1 3 5.4 C1=CC=C(C(=C1)C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O)Cl
CHEMBL2315528 ffar1_human Human No 7.7 EC50 = 20 Funct
Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis
289 6 1 3 3.4 C1=CC=C(C(=C1)CC#N)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL3288362 ffar1_human Human Yes 7.7 EC50 = 20 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay
314 8 1 4 3.3 CCOC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC=C2C
CHEMBL3288362 ffar1_human Human Yes 7.7 EC50 = 20 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
314 8 1 4 3.3 CCOC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC=C2C
CHEMBL3604067 ffar1_human Human No 7.7 EC50 = 20 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
395 7 1 8 3.5 CCOC(CC(=O)O)C1=CN=C(C=C1)OC2CCC3=C2C=CC=C3C(F)(F)F
CHEMBL3288362 ffar1_human Human Yes 7.7 EC50 = 20 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay
314 8 1 4 3.3 CCOC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC=C2C
CHEMBL2048613 ffar1_human Human No 7.7 EC50 = 20 Funct
Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
390 8 1 4 5.5 CC1=C(C(=CC=C1)C)C2=C(C=CC(=C2)COC3=CC=C(C=C3)CCC(=O)O)OC
CHEMBL3330549 ffar1_human Human No 7.7 EC50 = 20 Funct
Modulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assayModulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assay
529 8 1 9 7.4 CCC1C(N(N=C1C(F)(F)F)C2=CC=C(C=C2)CC3=C(C=C(C=C3)C4=C(C=CC(=C4)OC)F)C)CC(=O)O
CHEMBL3785637 ffar1_human Human No 7.7 EC50 = 20.4 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay
246 5 1 3 3.8 CC=C(C)C#CC1=CC(=C(C=C1)CCC(=O)O)F
CHEMBL3785637 ffar1_human Human No 7.7 EC50 = 20.4 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay
246 5 1 3 3.8 CC=C(C)C#CC1=CC(=C(C=C1)CCC(=O)O)F
CHEMBL597638 ffar1_human Human No 6.7 EC50 = 203 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
313 4 1 4 4.0 CC1=CC(=CC=C1)OC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL597638 ffar1_human Human No 6.7 EC50 = 203 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
313 4 1 4 4.0 CC1=CC(=CC=C1)OC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL1688454 ffar1_human Human No 6.7 EC50 = 204.2 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
348 8 1 4 4.7 C1=CC=C(C=C1)OC2=CC=C(C=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL382884 ffar1_human Human No 6.7 EC50 = 204.2 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
501 7 3 8 4.6 CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)CNC3=CC=C(C=C3)C4CC4C(=O)NC5CCNC5
CHEMBL1688454 ffar1_human Human No 6.7 EC50 = 204.2 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
348 8 1 4 4.7 C1=CC=C(C=C1)OC2=CC=C(C=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL382884 ffar1_human Human No 6.7 EC50 = 204.2 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
501 7 3 8 4.6 CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)CNC3=CC=C(C=C3)C4CC4C(=O)NC5CCNC5
CHEMBL2058525 ffar1_human Human No 5.7 EC50 = 2041.7 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
362 8 1 4 4.7 COC1=CC=C(C=C1)C2=CC=CC=C2COC3=CC=C(C=C3)CCC(=O)O
CHEMBL206880 ffar1_human Human No 5.7 EC50 = 2041.7 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
349 8 2 5 4.5 C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)OCC(=O)O
CHEMBL2058525 ffar1_human Human No 5.7 EC50 = 2041.7 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
362 8 1 4 4.7 COC1=CC=C(C=C1)C2=CC=CC=C2COC3=CC=C(C=C3)CCC(=O)O
CHEMBL2315250 ffar1_human Human No 5.7 EC50 = 2041.7 Funct
Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis
294 7 2 3 3.3 C1=CC=C(C(=C1)CCO)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL206880 ffar1_human Human No 5.7 EC50 = 2041.7 Funct
Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells
349 8 2 5 4.5 C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)OCC(=O)O
CHEMBL2381303 ffar1_human Human No 6.7 EC50 = 205.1 Funct
Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay
577 9 1 9 4.5 CS(=O)(=O)CCCOC1=CC(=C(C=C1)C2=CC(=CC(=C2)F)C3COC4=C(O3)C=C5C(=C4)C(CO5)CC(=O)O)Cl
CHEMBL596666 ffar1_human Human No 6.7 EC50 = 207 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
368 4 1 4 4.8 C1=CC(=CC=C1CC2C(=O)NC(=O)S2)OC3=CC(=CC(=C3)Cl)Cl
CHEMBL596666 ffar1_human Human No 6.7 EC50 = 207 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
368 4 1 4 4.8 C1=CC(=CC=C1CC2C(=O)NC(=O)S2)OC3=CC(=CC(=C3)Cl)Cl
CHEMBL3786526 ffar1_human Human No 6.7 EC50 = 208.9 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay
232 4 1 3 3.2 CC=CC#CC1=CC(=C(C=C1)CCC(=O)O)F
CHEMBL3786526 ffar1_human Human No 6.7 EC50 = 208.9 Funct
Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay
232 4 1 3 3.2 CC=CC#CC1=CC(=C(C=C1)CCC(=O)O)F
CHEMBL599271 ffar1_human Human No 5.7 EC50 = 2094 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
309 4 1 3 4.3 C1=CC=C(C=C1)C=CC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL599271 ffar1_human Human No 5.7 EC50 = 2094 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
309 4 1 3 4.3 C1=CC=C(C=C1)C=CC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL3604066 ffar1_human Human No 7.7 EC50 = 21 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
396 7 1 8 3.6 CCOC(CC(=O)O)C1=CC=C(C=C1)OC2COC3=C2C=CC=C3C(F)(F)F
CHEMBL2022252 ffar1_human Human No 7.7 EC50 = 21 Funct
Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA
424 6 1 4 5.9 CC1=C(C2=CC=CC=C2C=C1)C3=CC(=CC=C3)COC4=CC5=C(C=C4)C(CO5)CC(=O)O
CHEMBL3604066 ffar1_human Human No 7.7 EC50 = 21 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
396 7 1 8 3.6 CCOC(CC(=O)O)C1=CC=C(C=C1)OC2COC3=C2C=CC=C3C(F)(F)F
CHEMBL2022252 ffar1_human Human No 7.7 EC50 = 21 Funct
Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA
424 6 1 4 5.9 CC1=C(C2=CC=CC=C2C=C1)C3=CC(=CC=C3)COC4=CC5=C(C=C4)C(CO5)CC(=O)O
CHEMBL2163923 ffar1_human Human Yes 7.7 EC50 = 21.9 Funct
Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilizationAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization
525 11 1 7 4.7 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)OCCCS(=O)(=O)C
CHEMBL3601000 ffar1_human Human Yes 6.7 EC50 = 210 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
352 8 1 6 3.9 CCC1=CC=C(C=C1)C2=NOC(=N2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3604034 ffar1_human Human No 6.7 EC50 = 210 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
387 8 1 5 4.3 CCOC(CC(=O)O)C1=CC(=C(C=C1)OCC2=CC(=C(C=C2)Cl)Cl)F
CHEMBL3288345 ffar1_rat Rat No 6.7 EC50 = 210 Funct
Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay
361 7 1 4 4.5 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=CN=C(C=C3)CCC(=O)O
CHEMBL3601000 ffar1_human Human Yes 6.7 EC50 = 210 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
352 8 1 6 3.9 CCC1=CC=C(C=C1)C2=NOC(=N2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3604034 ffar1_human Human No 6.7 EC50 = 210 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
387 8 1 5 4.3 CCOC(CC(=O)O)C1=CC(=C(C=C1)OCC2=CC(=C(C=C2)Cl)Cl)F
CHEMBL3288345 ffar1_rat Rat No 6.7 EC50 = 210 Funct
Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay
361 7 1 4 4.5 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=CN=C(C=C3)CCC(=O)O
CHEMBL2151301 ffar1_human Human No 5.7 EC50 = 2100 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
519 10 1 5 9.0 CC(C)(C)C1=C(C=CC(=C1)COC2=CC=CC(=C2)C(CC(=O)O)C3CCCCC3)C4=C(C=CC(=C4)OC)F
CHEMBL2152068 ffar1_human Human No 5.7 EC50 = 2100 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
505 9 1 8 7.4 CC(C)(C)C1=C(C=CC(=C1)COC2=CC=CC(=C2)C(CC(=O)O)C(F)(F)F)C3=C(C=CC(=C3)OC)F
CHEMBL3604050 ffar1_human Human No 5.7 EC50 = 2100 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
315 8 1 5 2.3 CCOC(CC(=O)O)C1=CC=C(C=C1)OCC2=C(N=CC=C2)C
CHEMBL3288355 ffar1_rat Rat No 5.7 EC50 = 2100 Funct
Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay
375 7 1 4 5.3 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=NC=C(C=C3)CC(C)C(=O)O
CHEMBL2151301 ffar1_human Human No 5.7 EC50 = 2100 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
519 10 1 5 9.0 CC(C)(C)C1=C(C=CC(=C1)COC2=CC=CC(=C2)C(CC(=O)O)C3CCCCC3)C4=C(C=CC(=C4)OC)F
CHEMBL2152068 ffar1_human Human No 5.7 EC50 = 2100 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
505 9 1 8 7.4 CC(C)(C)C1=C(C=CC(=C1)COC2=CC=CC(=C2)C(CC(=O)O)C(F)(F)F)C3=C(C=CC(=C3)OC)F
CHEMBL3604050 ffar1_human Human No 5.7 EC50 = 2100 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
315 8 1 5 2.3 CCOC(CC(=O)O)C1=CC=C(C=C1)OCC2=C(N=CC=C2)C
CHEMBL3288355 ffar1_rat Rat No 5.7 EC50 = 2100 Funct
Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay
375 7 1 4 5.3 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=NC=C(C=C3)CC(C)C(=O)O
CHEMBL515995 ffar1_human Human No 4.7 EC50 = 21000 Funct
Agonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay
382 10 1 6 4.7 C1=CC=C(C=C1)N(CCOC2=CC=C(C=C2)CCCC(=O)O)C3=NC=CS3
CHEMBL3754659 ffar1_human Human No 4.7 EC50 = 21000 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum
445 8 1 5 4.8 CC1=C(C=CC(=C1)F)C2=CC(=CC=C2)COC3=CC=C(C=C3)C(CC(=O)O)C4=NC=CN4C
CHEMBL515995 ffar1_human Human No 4.7 EC50 = 21000 Funct
Agonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay
382 10 1 6 4.7 C1=CC=C(C=C1)N(CCOC2=CC=C(C=C2)CCCC(=O)O)C3=NC=CS3
CHEMBL3754659 ffar1_human Human No 4.7 EC50 = 21000 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum
445 8 1 5 4.8 CC1=C(C=CC(=C1)F)C2=CC(=CC=C2)COC3=CC=C(C=C3)C(CC(=O)O)C4=NC=CN4C
CHEMBL3758885 ffar1_human Human No 4.7 EC50 = 21010 Funct
Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay
393 7 1 5 3.8 C=CCN1C2=CC=CC=C2N=C1COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4
CHEMBL3758885 ffar1_human Human No 4.7 EC50 = 21010 Funct
Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay
393 7 1 5 3.8 C=CCN1C2=CC=CC=C2N=C1COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4
CHEMBL2385461 ffar1_human Human No 6.7 EC50 = 212 Funct
Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay
515 7 1 5 8.0 CC1(CCCC1C2=C(C=CC(=C2)COC3=CC4=C(CCC45CC5C(=O)O)C=C3)C6=C(C=CC(=C6)OC)F)C
CHEMBL3601050 ffar1_human Human Yes 5.7 EC50 = 2120 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
356 7 1 7 3.5 CC1=C(C=CC(=C1)C2=NOC(=N2)COC3=CC=C(C=C3)CCC(=O)O)F
CHEMBL3601050 ffar1_human Human Yes 5.7 EC50 = 2120 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
356 7 1 7 3.5 CC1=C(C=CC(=C1)C2=NOC(=N2)COC3=CC=C(C=C3)CCC(=O)O)F
CHEMBL2385472 ffar1_human Human No 5.7 EC50 = 2130 Funct
Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay
501 8 1 5 7.4 CC1(CCC=C1C2=C(C=CC(=C2)COC3=CC=CC(=C3)C4(CC4C(=O)O)C)C5=C(C=CC(=C5)OC)F)C
CHEMBL2386356 ffar1_human Human No 5.7 EC50 = 2138.0 Funct
Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay
251 5 1 3 2.7 C1=CC=C(C=C1)C#CC2=CN=C(C=C2)CCC(=O)O
CHEMBL1773247 ffar1_human Human No 4.7 EC50 = 21379.6 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
255 6 2 3 2.9 C1=CC=C(C=C1)NCC2=CC=C(C=C2)CCC(=O)O
CHEMBL1773247 ffar1_human Human No 4.7 EC50 = 21379.6 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
255 6 2 3 2.9 C1=CC=C(C=C1)NCC2=CC=C(C=C2)CCC(=O)O
CHEMBL3797889 ffar1_human Human No 6.7 EC50 = 214 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
393 8 1 6 4.5 CC1=C(C(=NO1)C)C#CC2=CC(=CC=C2)COC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL3797889 ffar1_human Human No 6.7 EC50 = 214 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
393 8 1 6 4.5 CC1=C(C(=NO1)C)C#CC2=CC(=CC=C2)COC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL606207 ffar1_human Human No 6.7 EC50 = 218 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
382 4 1 8 4.1 CC1=NC(=CC(=C1)C(F)(F)F)OC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL606207 ffar1_human Human No 6.7 EC50 = 218 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
382 4 1 8 4.1 CC1=NC(=CC(=C1)C(F)(F)F)OC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL234269 ffar1_human Human No 6.7 EC50 = 218.8 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
331 7 2 3 4.8 C1=CC=C(C=C1)C2=CC=C(C=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL234269 ffar1_human Human No 6.7 EC50 = 218.8 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
331 7 2 3 4.8 C1=CC=C(C=C1)C2=CC=C(C=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL2315552 ffar1_human Human No 6.7 EC50 = 218.8 Funct
Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis
280 6 1 3 3.7 COC1=CC=CC=C1C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL2381286 ffar1_human Human No 6.7 EC50 = 219.8 Funct
Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay
347 3 1 5 3.1 C1C(C2=CC3=C(C=C2O1)OC(CO3)C4=CC(=CC=C4)Cl)CC(=O)O
CHEMBL3265148 ffar1_human Human No 7.7 EC50 = 22 Funct
Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin
517 7 1 7 6.6 CC1(CCCC1C2=C(C=CC(=C2)COC3=NC=C4CCC5(C4=C3)CC5C(=O)O)C6=CC(=NC=C6F)OC)C
CHEMBL2047155 ffar1_human Human No 7.7 EC50 = 22 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
537 8 1 7 4.9 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)OC5CCS(=O)(=O)CC5
CHEMBL1688486 ffar1_human Human No 7.7 EC50 = 22 Funct
Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
360 7 1 3 5.5 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL3265148 ffar1_human Human No 7.7 EC50 = 22 Funct
Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin
517 7 1 7 6.6 CC1(CCCC1C2=C(C=CC(=C2)COC3=NC=C4CCC5(C4=C3)CC5C(=O)O)C6=CC(=NC=C6F)OC)C
CHEMBL2047155 ffar1_human Human No 7.7 EC50 = 22 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
537 8 1 7 4.9 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)OC5CCS(=O)(=O)CC5
CHEMBL2022247 ffar1_human Human No 7.7 EC50 = 22 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAAgonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA
388 6 1 4 5.0 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O
CHEMBL1688486 ffar1_human Human No 7.7 EC50 = 22 Funct
Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
360 7 1 3 5.5 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL2386362 ffar1_human Human No 7.7 EC50 = 22.4 Funct
Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay
282 5 1 3 4.2 CC1=CC=CC(=C1)C#CC2=CC(=C(C=C2)CCC(=O)O)F
CHEMBL3798575 ffar1_human Human No 7.6 EC50 = 22.9 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
399 8 1 7 4.1 CC1=C(C(=NO1)C)C2=C(C=CC(=C2)COC3=CC(=C(C=C3)CCC(=O)O)F)OC
CHEMBL3798575 ffar1_human Human No 7.6 EC50 = 22.9 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
399 8 1 7 4.1 CC1=C(C(=NO1)C)C2=C(C=CC(=C2)COC3=CC(=C(C=C3)CCC(=O)O)F)OC
CHEMBL2386353 ffar1_human Human Yes 7.6 EC50 = 22.9 Funct
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assay
307 6 1 4 3.5 C1=CC=C(C(=C1)CC#N)C#CC2=CC(=C(C=C2)CCC(=O)O)F
CHEMBL2151297 ffar1_human Human No 5.7 EC50 = 2200 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
479 10 1 5 7.6 CC(C)C(CC(=O)O)C1=CC(=CC=C1)OCC2=CC(=C(C=C2)C3=C(C=CC(=C3)OC)F)C(C)(C)C
CHEMBL229225 ffar1_mouse Mouse No 5.7 EC50 = 2200 Funct
Agonist activity at GPR40 in mouse MIN6 cells assessed as stimulation of 25 mM glucose-mediated insulin secretionAgonist activity at GPR40 in mouse MIN6 cells assessed as stimulation of 25 mM glucose-mediated insulin secretion
326 9 1 3 5.1 CCC(CC)COC1=CC=C(C=C1)C(CC(=O)O)C2=CC=CC=C2
CHEMBL207881 ffar1_human Human Yes 5.7 EC50 = 2200 Funct
Agonist activity at human GPR40 H86A mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 H86A mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calcium
347 8 2 4 4.7 C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL2151297 ffar1_human Human No 5.7 EC50 = 2200 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
479 10 1 5 7.6 CC(C)C(CC(=O)O)C1=CC(=CC=C1)OCC2=CC(=C(C=C2)C3=C(C=CC(=C3)OC)F)C(C)(C)C
CHEMBL229225 ffar1_mouse Mouse No 5.7 EC50 = 2200 Funct
Agonist activity at GPR40 in mouse MIN6 cells assessed as stimulation of 25 mM glucose-mediated insulin secretionAgonist activity at GPR40 in mouse MIN6 cells assessed as stimulation of 25 mM glucose-mediated insulin secretion
326 9 1 3 5.1 CCC(CC)COC1=CC=C(C=C1)C(CC(=O)O)C2=CC=CC=C2
CHEMBL207881 ffar1_human Human Yes 5.7 EC50 = 2200 Funct
Agonist activity at human GPR40 H86A mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 H86A mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calcium
347 8 2 4 4.7 C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL3754682 ffar1_human Human No 4.7 EC50 = 22000 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum
461 8 1 4 5.3 CC1=C(C=CC=C1Cl)C2=CC(=CC=C2)COC3=CC=C(C=C3)C(CC(=O)O)C4=NC=CN4C
CHEMBL3754682 ffar1_human Human No 4.7 EC50 = 22000 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum
461 8 1 4 5.3 CC1=C(C=CC=C1Cl)C2=CC(=CC=C2)COC3=CC=C(C=C3)C(CC(=O)O)C4=NC=CN4C
CHEMBL597435 ffar1_human Human Yes 5.7 EC50 = 2219 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
283 3 1 3 3.7 C1=CC=C(C=C1)C2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL597435 ffar1_human Human Yes 5.7 EC50 = 2219 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
283 3 1 3 3.7 C1=CC=C(C=C1)C2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL207881 ffar1_human Human Yes 6.7 EC50 = 223.9 Funct
Agonist activity at human GPR40 expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 expressed in HEK-EM 293 cells assessed as increase in intracellular calcium
347 8 2 4 4.7 C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL2315554 ffar1_human Human No 6.7 EC50 = 223.9 Funct
Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis
334 6 1 6 4.9 C1=CC=C(C(=C1)C#CC2=CC=C(C=C2)CCC(=O)O)OC(F)(F)F
CHEMBL207881 ffar1_human Human Yes 6.7 EC50 = 223.9 Funct
Agonist activity at human GPR40 expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 expressed in HEK-EM 293 cells assessed as increase in intracellular calcium
347 8 2 4 4.7 C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCC(=O)O
CHEMBL1777876 ffar1_human Human No 6.7 EC50 = 224 Funct
Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serumAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serum
455 6 1 10 5.4 CC#CC(C1C(=O)NC(=O)O1)C2=CC=C(C=C2)OC3=C(C=C(C=C3)C(F)(F)F)OC(F)F
CHEMBL1777876 ffar1_human Human No 6.7 EC50 = 224 Funct
Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serumAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serum
455 6 1 10 5.4 CC#CC(C1C(=O)NC(=O)O1)C2=CC=C(C=C2)OC3=C(C=C(C=C3)C(F)(F)F)OC(F)F
CHEMBL402054 ffar1_human Human Yes 4.7 EC50 = 22600 Funct
Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay
325 5 1 6 2.9 C1=CC(=CC=C1C=C2C(=O)N(C(=S)S2)CCCC(=O)O)F
CHEMBL402054 ffar1_human Human Yes 4.7 EC50 = 22600 Funct
Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay
325 5 1 6 2.9 C1=CC(=CC=C1C=C2C(=O)N(C(=S)S2)CCCC(=O)O)F
CHEMBL3265142 ffar1_human Human No 6.6 EC50 = 227 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
533 10 1 6 7.1 CC1(CCCOC1C2=C(C=CC(=C2)COC3=CC=CC(=C3)C(CC(=O)O)C4CC4)C5=C(C=CC(=C5)OC)F)C
CHEMBL3265142 ffar1_human Human No 6.6 EC50 = 227 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
533 10 1 6 7.1 CC1(CCCOC1C2=C(C=CC(=C2)COC3=CC=CC(=C3)C(CC(=O)O)C4CC4)C5=C(C=CC(=C5)OC)F)C
CHEMBL591214 ffar1_human Human No 5.6 EC50 = 2287 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
368 4 1 8 3.7 C1=CC(=C(N=C1)OC2=CC=C(C=C2)CC3C(=O)NC(=O)S3)C(F)(F)F
CHEMBL591214 ffar1_human Human No 5.6 EC50 = 2287 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
368 4 1 8 3.7 C1=CC(=C(N=C1)OC2=CC=C(C=C2)CC3C(=O)NC(=O)S3)C(F)(F)F
CHEMBL2315534 ffar1_human Human No 5.6 EC50 = 2290.9 Funct
Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis
262 4 1 2 4.3 CC1=CC=CC=C1C#CC2=CC=C(C=C2)C=CC(=O)O
CHEMBL1829173 ffar1_human Human Yes 7.6 EC50 = 23 Funct
Agonist activity at FFA1 receptor (unknown origin)Agonist activity at FFA1 receptor (unknown origin)
438 7 1 6 6.2 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC(=C2)C3=CC=C(C=C3)C(F)(F)F
CHEMBL3604044 ffar1_human Human No 7.6 EC50 = 23 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
392 10 1 5 4.5 CCOC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC(=CC=C2)OC3=CC=CC=C3
CHEMBL2048619 ffar1_human Human No 7.6 EC50 = 23 Funct
Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
479 9 1 6 6.0 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC(=C(C=C3)CCC(=O)O)F)C)OC4CCOCC4
CHEMBL2048626 ffar1_human Human No 7.6 EC50 = 23 Funct
Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
526 9 2 7 5.5 CC1=CC(=CC(=C1C2=CC(=CC=C2)CNC3=CC(=C(C=C3)CCC(=O)O)F)C)OC4CCS(=O)(=O)CC4
CHEMBL1829173 ffar1_rat Rat Yes 7.6 EC50 = 23 Funct
Agonist activity at rat GPR40Agonist activity at rat GPR40
438 7 1 6 6.2 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC(=C2)C3=CC=C(C=C3)C(F)(F)F
CHEMBL2022244 ffar1_human Human No 7.6 EC50 = 23 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAAgonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA
401 6 1 3 6.4 CC1=C(C(=CC=C1)C)C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CCC4)CC(=O)O
CHEMBL3604044 ffar1_human Human No 7.6 EC50 = 23 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay
392 10 1 5 4.5 CCOC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC(=CC=C2)OC3=CC=CC=C3
CHEMBL2048619 ffar1_human Human No 7.6 EC50 = 23 Funct
Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
479 9 1 6 6.0 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC(=C(C=C3)CCC(=O)O)F)C)OC4CCOCC4
CHEMBL2048626 ffar1_human Human No 7.6 EC50 = 23 Funct
Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
526 9 2 7 5.5 CC1=CC(=CC(=C1C2=CC(=CC=C2)CNC3=CC(=C(C=C3)CCC(=O)O)F)C)OC4CCS(=O)(=O)CC4
CHEMBL1829173 ffar1_rat Rat Yes 7.6 EC50 = 23 Funct
Agonist activity at rat GPR40Agonist activity at rat GPR40
438 7 1 6 6.2 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC(=C2)C3=CC=C(C=C3)C(F)(F)F
CHEMBL2164240 ffar1_human Human No 7.6 EC50 = 23.4 Funct
Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilizationAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization
377 8 2 4 5.7 CCC1=CC=CC=C1C2=CC(=CC=C2)CNC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL3288361 ffar1_human Human No 6.6 EC50 = 230 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay
301 8 1 5 2.2 CCOC(CC(=O)O)C1=CN=C(C=C1)OCC2=CC=CC=C2
CHEMBL3288361 ffar1_human Human No 6.6 EC50 = 230 Funct
Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay
301 8 1 5 2.2 CCOC(CC(=O)O)C1=CN=C(C=C1)OCC2=CC=CC=C2
CHEMBL2151287 ffar1_human Human No 5.6 EC50 = 2300 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
400 8 1 4 5.3 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=C(C=C2)C3=CC(=CC=C3)OC
CHEMBL2151290 ffar1_human Human No 5.6 EC50 = 2300 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
418 8 1 5 5.4 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=C(C=C2)C3=C(C=CC(=C3)OC)F
CHEMBL2151287 ffar1_human Human No 5.6 EC50 = 2300 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
400 8 1 4 5.3 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=C(C=C2)C3=CC(=CC=C3)OC
CHEMBL2151290 ffar1_human Human No 5.6 EC50 = 2300 Funct
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
418 8 1 5 5.4 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=C(C=C2)C3=C(C=CC(=C3)OC)F
CHEMBL3752168 ffar1_human Human No 4.6 EC50 = 23000 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin
491 9 1 6 3.6 CN1C=CN=C1C(CC(=O)O)C2=CC=C(C=C2)OCC3=CC=CC(=C3)C4=CC=CC=C4S(=O)(=O)C
CHEMBL3753362 ffar1_human Human No 4.6 EC50 = 23000 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum
475 8 1 4 5.7 CC1=C(C=CC(=C1)Cl)C2=C(C(=CC=C2)COC3=CC=C(C=C3)C(CC(=O)O)C4=NC=CN4C)C
CHEMBL3752168 ffar1_human Human No 4.6 EC50 = 23000 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin
491 9 1 6 3.6 CN1C=CN=C1C(CC(=O)O)C2=CC=C(C=C2)OCC3=CC=CC(=C3)C4=CC=CC=C4S(=O)(=O)C
CHEMBL3753362 ffar1_human Human No 4.6 EC50 = 23000 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum
475 8 1 4 5.7 CC1=C(C=CC(=C1)Cl)C2=C(C(=CC=C2)COC3=CC=C(C=C3)C(CC(=O)O)C4=NC=CN4C)C
CHEMBL3759133 ffar1_human Human No 4.6 EC50 = 23120 Funct
Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay
392 5 1 4 4.2 C1=CC(=CC=C1CC2C(=O)NC(=O)S2)OCC3=CC=C(C=C3)Br
CHEMBL3759133 ffar1_human Human No 4.6 EC50 = 23120 Funct
Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay
392 5 1 4 4.2 C1=CC(=CC=C1CC2C(=O)NC(=O)S2)OCC3=CC=C(C=C3)Br
CHEMBL3265150 ffar1_human Human No 6.6 EC50 = 235 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
522 10 1 7 6.4 CC1(CCC2=C1C=C(C=C2)OCC3=CC(=C(C=C3)C4=CC(=NC=C4F)OC)C(C(C)(C)C)OC)CC(=O)O
CHEMBL3265150 ffar1_human Human No 6.6 EC50 = 235 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin
522 10 1 7 6.4 CC1(CCC2=C1C=C(C=C2)OCC3=CC(=C(C=C3)C4=CC(=NC=C4F)OC)C(C(C)(C)C)OC)CC(=O)O
CHEMBL604317 ffar1_human Human No 4.6 EC50 = 23587 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
453 4 1 8 5.6 C1=CC=C2C(=C1)C(=CC=C2OC3=C(C=C(C=N3)C(F)(F)F)Cl)CC4C(=O)NC(=O)S4
CHEMBL604317 ffar1_human Human No 4.6 EC50 = 23587 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
453 4 1 8 5.6 C1=CC=C2C(=C1)C(=CC=C2OC3=C(C=C(C=N3)C(F)(F)F)Cl)CC4C(=O)NC(=O)S4
CHEMBL603063 ffar1_human Human No 6.6 EC50 = 237 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
368 4 1 8 3.7 C1=CC(=CC=C1CC2C(=O)NC(=O)S2)OC3=NC=CC(=C3)C(F)(F)F
CHEMBL603063 ffar1_human Human No 6.6 EC50 = 237 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
368 4 1 8 3.7 C1=CC(=CC=C1CC2C(=O)NC(=O)S2)OC3=NC=CC(=C3)C(F)(F)F
CHEMBL609034 ffar1_human Human No 6.6 EC50 = 238 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
327 4 1 4 4.3 CC1=CC(=C(C=C1)C)OC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL609034 ffar1_human Human No 6.6 EC50 = 238 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
327 4 1 4 4.3 CC1=CC(=C(C=C1)C)OC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL394666 ffar1_human Human No 6.6 EC50 = 239.9 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
334 6 2 3 3.8 C1=CC(=CC(=C1)Br)CNC2=CC=C(C=C2)CCC(=O)O
CHEMBL2315528 ffar1_human Human No 6.6 EC50 = 239.9 Funct
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assay in presence of bovine serum albuminAgonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assay in presence of bovine serum albumin
289 6 1 3 3.4 C1=CC=C(C(=C1)CC#N)C#CC2=CC=C(C=C2)CCC(=O)O
CHEMBL394666 ffar1_human Human No 6.6 EC50 = 239.9 Funct
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
334 6 2 3 3.8 C1=CC(=CC(=C1)Br)CNC2=CC=C(C=C2)CCC(=O)O
CHEMBL3601051 ffar1_human Human Yes 5.6 EC50 = 2390 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
338 7 1 6 3.5 CC(C1=NC(=NO1)C2=CC=CC=C2)OC3=CC=C(C=C3)CCC(=O)O
CHEMBL3601051 ffar1_human Human Yes 5.6 EC50 = 2390 Funct
Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin
338 7 1 6 3.5 CC(C1=NC(=NO1)C2=CC=CC=C2)OC3=CC=C(C=C3)CCC(=O)O
CHEMBL2047151 ffar1_human Human No 7.6 EC50 = 24 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
489 9 1 6 5.3 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)OCC5(COC5)C
CHEMBL2022255 ffar1_human Human No 7.6 EC50 = 24 Funct
Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA
418 7 1 5 5.0 CC1=C(C(=CC=C1)C)C2=C(C=CC(=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)OC
CHEMBL2047151 ffar1_human Human No 7.6 EC50 = 24 Funct
Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
489 9 1 6 5.3 CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)OCC5(COC5)C
CHEMBL2022255 ffar1_human Human No 7.6 EC50 = 24 Funct
Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA
418 7 1 5 5.0 CC1=C(C(=CC=C1)C)C2=C(C=CC(=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)OC
CHEMBL3798341 ffar1_human Human No 7.6 EC50 = 24.3 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
399 8 1 7 4.1 CC1=C(C(=NO1)C)C2=CC(=C(C=C2)OC)COC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL3798341 ffar1_human Human No 7.6 EC50 = 24.3 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
399 8 1 7 4.1 CC1=C(C(=NO1)C)C2=CC(=C(C=C2)OC)COC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL3799946 ffar1_human Human No 7.6 EC50 = 24.8 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
369 7 1 6 4.1 CC1=C(C(=NO1)C)C2=CC(=CC=C2)COC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL3799946 ffar1_human Human No 7.6 EC50 = 24.8 Funct
Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay
369 7 1 6 4.1 CC1=C(C(=NO1)C)C2=CC(=CC=C2)COC3=CC(=C(C=C3)CCC(=O)O)F
CHEMBL1688464 ffar1_human Human No 6.6 EC50 = 240 Funct
Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA
346 7 1 3 5.1 CC1=CC=CC(=C1)C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL601504 ffar1_human Human No 6.6 EC50 = 240 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
334 4 1 4 4.2 C1=CC(=CC=C1CC2C(=O)NC(=O)S2)OC3=CC=C(C=C3)Cl
CHEMBL1939652 ffar1_human Human No 6.6 EC50 = 240 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay
370 7 1 3 5.4 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC=C2C3=CC=CC=C3
CHEMBL3753362 ffar1_human Human No 6.6 EC50 = 240 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin
475 8 1 4 5.7 CC1=C(C=CC(=C1)Cl)C2=C(C(=CC=C2)COC3=CC=C(C=C3)C(CC(=O)O)C4=NC=CN4C)C
CHEMBL1688464 ffar1_human Human No 6.6 EC50 = 240 Funct
Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA
346 7 1 3 5.1 CC1=CC=CC(=C1)C2=CC(=CC=C2)COC3=CC=C(C=C3)CCC(=O)O
CHEMBL601504 ffar1_human Human No 6.6 EC50 = 240 Funct
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA
334 4 1 4 4.2 C1=CC(=CC=C1CC2C(=O)NC(=O)S2)OC3=CC=C(C=C3)Cl
CHEMBL1939652 ffar1_human Human No 6.6 EC50 = 240 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay
370 7 1 3 5.4 CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC=C2C3=CC=CC=C3
CHEMBL3753362 ffar1_human Human No 6.6 EC50 = 240 Funct
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin
475 8 1 4 5.7 CC1=C(C=CC(=C1)Cl)C2=C(C(=CC=C2)COC3=CC=C(C=C3)C(CC(=O)O)C4=NC=CN4C)C
CHEMBL1777875 ffar1_human Human No 4.6 EC50 = 24490 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
395 5 1 6 5.5 CC#CC1(CC1C(=O)O)C2=CC=C(C=C2)OC3=C(C=C(C=C3)C(F)(F)F)Cl
CHEMBL1777875 ffar1_human Human No 4.6 EC50 = 24490 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
395 5 1 6 5.5 CC#CC1(CC1C(=O)O)C2=CC=C(C=C2)OC3=C(C=C(C=C3)C(F)(F)F)Cl
CHEMBL1773251 ffar1_human Human No 5.6 EC50 = 2454.7 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
266 4 1 3 3.7 C1=CC=C(C=C1)C2=CC3=C(O2)C=CC(=C3)CCC(=O)O
CHEMBL1773251 ffar1_human Human No 5.6 EC50 = 2454.7 Funct
Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay
266 4 1 3 3.7 C1=CC=C(C=C1)C2=CC3=C(O2)C=CC(=C3)CCC(=O)O
CHEMBL255073 ffar1_human Human Yes 4.6 EC50 = 24600 Funct
Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay
271 4 2 5 2.9 C1OC2=C(O1)C=C(C=C2)CNC3=CC=C(C=C3)C(=O)O
CHEMBL255073 ffar1_human Human Yes 4.6 EC50 = 24600 Funct
Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay
271 4 2 5 2.9 C1OC2=C(O1)C=C(C=C2)CNC3=CC=C(C=C3)C(=O)O
CHEMBL1777864 ffar1_human Human No 6.6 EC50 = 247 Funct
Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albuminAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albumin
355 5 1 4 4.8 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=CC=C(C3=CC=CC=C32)C#N
CHEMBL1777864 ffar1_human Human No 6.6 EC50 = 247 Funct
Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albuminAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albumin
355 5 1 4 4.8 CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=CC=C(C3=CC=CC=C32)C#N
CHEMBL1777859 ffar1_human Human No 5.6 EC50 = 2484 Funct
Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay
325 5 1 3 4.8 CC(CC(=O)O)C1=CC=C(C=C1)OC2=C(C=C(C=C2)Cl)Cl