Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
11954197 6954 31 None 1 3 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 10.1016/j.bmcl.2016.09.029
4350 6954 31 None 1 3 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 10.1016/j.bmcl.2016.09.029
CHEMBL4788348 6954 31 None 1 3 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 10.1016/j.bmcl.2016.09.029
162663790 188677 0 None 10 3 Human 10.0 pEC50 = 10.0 Functional
Agonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 486 5 3 3 6.4 C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@]3(O)C(F)(F)F 10.1016/j.bmcl.2016.09.029
CHEMBL4779254 188677 0 None 10 3 Human 10.0 pEC50 = 10.0 Functional
Agonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 486 5 3 3 6.4 C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@]3(O)C(F)(F)F 10.1016/j.bmcl.2016.09.029
11954197 6954 31 None 1 3 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 10.1016/j.bmcl.2016.09.029
4350 6954 31 None 1 3 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 10.1016/j.bmcl.2016.09.029
CHEMBL4788348 6954 31 None 1 3 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 10.1016/j.bmcl.2016.09.029
11954197 6954 31 None -1 3 Mouse 9.2 pEC50 = 9.2 Functional
Agonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 10.1016/j.bmcl.2016.09.029
4350 6954 31 None -1 3 Mouse 9.2 pEC50 = 9.2 Functional
Agonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 10.1016/j.bmcl.2016.09.029
CHEMBL4788348 6954 31 None -1 3 Mouse 9.2 pEC50 = 9.2 Functional
Agonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 10.1016/j.bmcl.2016.09.029
440985 189385 17 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 418 6 3 3 5.3 CC(CO)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.bmcl.2016.09.029
CHEMBL4788277 189385 17 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 418 6 3 3 5.3 CC(CO)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.bmcl.2016.09.029
162663790 188677 0 None -15 3 Mouse 8.8 pEC50 = 8.8 Functional
Agonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 486 5 3 3 6.4 C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@]3(O)C(F)(F)F 10.1016/j.bmcl.2016.09.029
CHEMBL4779254 188677 0 None -15 3 Mouse 8.8 pEC50 = 8.8 Functional
Agonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 486 5 3 3 6.4 C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@]3(O)C(F)(F)F 10.1016/j.bmcl.2016.09.029
162656664 187636 0 None -3 3 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 486 5 3 3 6.4 C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@@]3(O)C(F)(F)F 10.1016/j.bmcl.2016.09.029
CHEMBL4757291 187636 0 None -3 3 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 486 5 3 3 6.4 C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@@]3(O)C(F)(F)F 10.1016/j.bmcl.2016.09.029
4355 6965 13 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 10.1016/j.bmcl.2016.09.029
473142 6965 13 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 10.1016/j.bmcl.2016.09.029
CHEMBL3311219 6965 13 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 10.1016/j.bmcl.2016.09.029
162656664 187636 0 None 3 3 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 486 5 3 3 6.4 C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@@]3(O)C(F)(F)F 10.1016/j.bmcl.2016.09.029
CHEMBL4757291 187636 0 None 3 3 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 486 5 3 3 6.4 C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@@]3(O)C(F)(F)F 10.1016/j.bmcl.2016.09.029
67426622 188489 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 418 6 3 3 5.3 CC(CO)CCC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@@H]3O 10.1016/j.bmcl.2016.09.029
CHEMBL4776911 188489 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 418 6 3 3 5.3 CC(CO)CCC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@@H]3O 10.1016/j.bmcl.2016.09.029
73330414 127711 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 432 3 0 2 4.1 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)c2ccc(Cl)cc2)CC1 nan
CHEMBL3560809 127711 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 432 3 0 2 4.1 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)c2ccc(Cl)cc2)CC1 nan
13052 9596 56 None 4 2 Human 9.3 pIC50 = 9.3 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br nan
36295259 9596 56 None 4 2 Human 9.3 pIC50 = 9.3 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br nan
CHEMBL3262896 9596 56 None 4 2 Human 9.3 pIC50 = 9.3 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br nan
73330413 127713 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 398 3 0 2 3.4 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)c2ccccc2)CC1 nan
CHEMBL3560864 127713 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 398 3 0 2 3.4 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)c2ccccc2)CC1 nan
39566276 127715 0 None - 1 Human 9.0 pIC50 = 9.0 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 412 3 0 2 3.8 Cc1ccc(C(=O)N2CCN(C(=O)/C=C/c3ccc(Br)cc3)CC2)cc1 nan
CHEMBL3560888 127715 0 None - 1 Human 9.0 pIC50 = 9.0 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 412 3 0 2 3.8 Cc1ccc(C(=O)N2CCN(C(=O)/C=C/c3ccc(Br)cc3)CC2)cc1 nan
73169083 127688 26 None - 1 Human 9.0 pIC50 = 9.0 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 418 4 0 2 4.5 O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2ccc(Cl)cc2)CC1 nan
CHEMBL3560331 127688 26 None - 1 Human 9.0 pIC50 = 9.0 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 418 4 0 2 4.5 O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2ccc(Cl)cc2)CC1 nan
71295857 127683 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 426 4 0 3 3.3 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)C2=Cc3ccccc3CC2)CC1 nan
CHEMBL3560117 127683 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 426 4 0 3 3.3 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)C2=Cc3ccccc3CC2)CC1 nan
73330415 127730 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 422 3 0 2 4.6 O=C(/C=C/c1ccc(Cl)c(Cl)c1)N1CCN(C(=O)c2ccc(Cl)cc2)CC1 nan
CHEMBL3561364 127730 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 422 3 0 2 4.6 O=C(/C=C/c1ccc(Cl)c(Cl)c1)N1CCN(C(=O)c2ccc(Cl)cc2)CC1 nan
73330396 127744 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 416 4 0 2 4.3 Cc1cc(CN2CCN(C(=O)/C=C/c3ccc(Br)cc3)CC2)ccc1F nan
CHEMBL3561756 127744 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 416 4 0 2 4.3 Cc1cc(CN2CCN(C(=O)/C=C/c3ccc(Br)cc3)CC2)ccc1F nan
71295907 127732 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 512 4 0 3 3.8 O=C(/C=C/c1ccc(Br)cc1)N1CCN(S(=O)(=O)c2ccc(Br)cc2)CC1 nan
CHEMBL3561399 127732 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 512 4 0 3 3.8 O=C(/C=C/c1ccc(Br)cc1)N1CCN(S(=O)(=O)c2ccc(Br)cc2)CC1 nan
73330421 127681 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 452 4 0 2 5.1 O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 nan
CHEMBL3560041 127681 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 452 4 0 2 5.1 O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 nan
73330424 127695 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 423 3 0 3 3.3 N#Cc1ccc(C(=O)N2CCN(C(=O)/C=C/c3ccc(Br)cc3)CC2)cc1 nan
CHEMBL3560453 127695 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 423 3 0 3 3.3 N#Cc1ccc(C(=O)N2CCN(C(=O)/C=C/c3ccc(Br)cc3)CC2)cc1 nan
73330403 127727 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 398 4 0 2 4.1 Cc1ccc(CN2CCN(C(=O)/C=C/c3ccc(Br)cc3)CC2)cc1 nan
CHEMBL3561255 127727 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 398 4 0 2 4.1 Cc1ccc(CN2CCN(C(=O)/C=C/c3ccc(Br)cc3)CC2)cc1 nan
46399493 127706 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 466 3 0 2 4.5 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)c2ccc(C(F)(F)F)cc2)CC1 nan
CHEMBL3560732 127706 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 466 3 0 2 4.5 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)c2ccc(C(F)(F)F)cc2)CC1 nan
13052 9596 56 None 4 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
36295259 9596 56 None 4 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
CHEMBL3262896 9596 56 None 4 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
86580332 117821 1 None -3 2 Mouse 7.0 pIC50 = 7 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 416 5 0 3 2.7 O=C(COc1ccc(Br)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL3262877 117821 1 None -3 2 Mouse 7.0 pIC50 = 7 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 416 5 0 3 2.7 O=C(COc1ccc(Br)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
13052 9596 56 None 4 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
36295259 9596 56 None 4 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
CHEMBL3262896 9596 56 None 4 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
26204807 127710 2 None - 1 Human 7.9 pIC50 = 7.9 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 408 4 0 3 3.0 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2cccc(Cl)c2)CC1 nan
CHEMBL3560763 127710 2 None - 1 Human 7.9 pIC50 = 7.9 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 408 4 0 3 3.0 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2cccc(Cl)c2)CC1 nan
8381950 127675 1 None - 1 Human 7.0 pIC50 = 7.0 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 402 6 0 3 2.9 O=C(CCc1ccc(F)cc1)N1CCN(S(=O)(=O)/C=C/c2ccccc2)CC1 nan
CHEMBL3559877 127675 1 None - 1 Human 7.0 pIC50 = 7.0 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 402 6 0 3 2.9 O=C(CCc1ccc(F)cc1)N1CCN(S(=O)(=O)/C=C/c2ccccc2)CC1 nan
2671117 127697 3 None - 1 Human 7.9 pIC50 = 7.9 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 404 5 0 4 2.4 COc1ccc(S(=O)(=O)N2CCN(C(=O)/C=C/c3ccc(F)cc3)CC2)cc1 nan
CHEMBL3560467 127697 3 None - 1 Human 7.9 pIC50 = 7.9 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 404 5 0 4 2.4 COc1ccc(S(=O)(=O)N2CCN(C(=O)/C=C/c3ccc(F)cc3)CC2)cc1 nan
71295891 127691 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 430 4 0 3 3.7 CC(C)(C)c1ccc(S(=O)(=O)N2CCN(C(=O)/C=C/c3ccc(F)cc3)CC2)cc1 nan
CHEMBL3560404 127691 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 430 4 0 3 3.7 CC(C)(C)c1ccc(S(=O)(=O)N2CCN(C(=O)/C=C/c3ccc(F)cc3)CC2)cc1 nan
2634553 127672 4 None - 1 Human 7.9 pIC50 = 7.9 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 374 4 0 3 2.4 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2ccccc2)CC1 nan
CHEMBL3559792 127672 4 None - 1 Human 7.9 pIC50 = 7.9 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 374 4 0 3 2.4 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2ccccc2)CC1 nan
86579984 117837 0 None 1 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 398 4 0 3 3.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(Cl)c(C)c3)CC2)cc1 10.1021/jm4019355
CHEMBL3262892 117837 0 None 1 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 398 4 0 3 3.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(Cl)c(C)c3)CC2)cc1 10.1021/jm4019355
26867780 127694 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 419 5 0 5 2.3 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2ccc([N+](=O)[O-])cc2)CC1 nan
CHEMBL3560431 127694 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 419 5 0 5 2.3 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2ccc([N+](=O)[O-])cc2)CC1 nan
1072081 117820 18 None 6 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 388 5 0 3 3.1 O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL3262876 117820 18 None 6 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 388 5 0 3 3.1 O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
86579984 117837 0 None 1 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 398 4 0 3 3.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(Cl)c(C)c3)CC2)cc1 10.1021/jm4019355
CHEMBL3262892 117837 0 None 1 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 398 4 0 3 3.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(Cl)c(C)c3)CC2)cc1 10.1021/jm4019355
13052 9596 56 None -4 2 Mouse 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
36295259 9596 56 None -4 2 Mouse 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
CHEMBL3262896 9596 56 None -4 2 Mouse 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
73330394 127674 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 408 4 0 2 5.0 O=C(/C=C/c1ccc(Cl)c(Cl)c1)N1CCN(Cc2ccc(Cl)cc2)CC1 nan
CHEMBL3559855 127674 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 408 4 0 2 5.0 O=C(/C=C/c1ccc(Cl)c(Cl)c1)N1CCN(Cc2ccc(Cl)cc2)CC1 nan
26867530 127733 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 478 6 0 4 3.4 CCOc1ccc(/C=C/C(=O)N2CCN(S(=O)(=O)c3ccc(Br)cc3)CC2)cc1 nan
CHEMBL3561444 127733 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 478 6 0 4 3.4 CCOc1ccc(/C=C/C(=O)N2CCN(S(=O)(=O)c3ccc(Br)cc3)CC2)cc1 nan
13052 9596 56 None -4 2 Mouse 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
36295259 9596 56 None -4 2 Mouse 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
CHEMBL3262896 9596 56 None -4 2 Mouse 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
898463 127705 9 None - 1 Human 7.8 pIC50 = 7.8 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 322 3 0 2 2.6 CCN1CCN(C(=O)/C=C/c2ccc(Br)cc2)CC1 nan
CHEMBL3560691 127705 9 None - 1 Human 7.8 pIC50 = 7.8 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 322 3 0 2 2.6 CCN1CCN(C(=O)/C=C/c2ccc(Br)cc2)CC1 nan
90655991 117839 0 None 1 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 396 3 0 3 3.3 O=C(/C=C/c1ccc(Cl)cc1)N1CCN(C(=O)c2ccc3c(c2)CCO3)CC1 10.1021/jm4019355
CHEMBL3262894 117839 0 None 1 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 396 3 0 3 3.3 O=C(/C=C/c1ccc(Cl)cc1)N1CCN(C(=O)c2ccc3c(c2)CCO3)CC1 10.1021/jm4019355
90655991 117839 0 None 1 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 396 3 0 3 3.3 O=C(/C=C/c1ccc(Cl)cc1)N1CCN(C(=O)c2ccc3c(c2)CCO3)CC1 10.1021/jm4019355
CHEMBL3262894 117839 0 None 1 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 396 3 0 3 3.3 O=C(/C=C/c1ccc(Cl)cc1)N1CCN(C(=O)c2ccc3c(c2)CCO3)CC1 10.1021/jm4019355
86579939 117827 0 None 2 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 366 4 0 2 3.1 Cc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1F 10.1021/jm4019355
CHEMBL3262883 117827 0 None 2 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 366 4 0 2 3.1 Cc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1F 10.1021/jm4019355
86579982 117835 0 None 1 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 408 5 0 5 2.5 COC(=O)c1ccc(C(=O)N2CCN(C(=O)/C=C/c3ccc(OC)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262890 117835 0 None 1 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 408 5 0 5 2.5 COC(=O)c1ccc(C(=O)N2CCN(C(=O)/C=C/c3ccc(OC)cc3)CC2)cc1 10.1021/jm4019355
86579939 117827 0 None 2 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 366 4 0 2 3.1 Cc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1F 10.1021/jm4019355
CHEMBL3262883 117827 0 None 2 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 366 4 0 2 3.1 Cc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1F 10.1021/jm4019355
86579982 117835 0 None 1 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 408 5 0 5 2.5 COC(=O)c1ccc(C(=O)N2CCN(C(=O)/C=C/c3ccc(OC)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262890 117835 0 None 1 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 408 5 0 5 2.5 COC(=O)c1ccc(C(=O)N2CCN(C(=O)/C=C/c3ccc(OC)cc3)CC2)cc1 10.1021/jm4019355
26559312 127708 2 None - 1 Human 7.8 pIC50 = 7.8 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 452 4 0 3 3.1 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2cccc(Br)c2)CC1 nan
CHEMBL3560750 127708 2 None - 1 Human 7.8 pIC50 = 7.8 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 452 4 0 3 3.1 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2cccc(Br)c2)CC1 nan
90655990 117836 0 None 1 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 392 4 0 4 2.6 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc4c(c3)CCO4)CC2)cc1 10.1021/jm4019355
CHEMBL3262891 117836 0 None 1 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 392 4 0 4 2.6 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc4c(c3)CCO4)CC2)cc1 10.1021/jm4019355
86579982 117835 0 None -1 2 Mouse 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 408 5 0 5 2.5 COC(=O)c1ccc(C(=O)N2CCN(C(=O)/C=C/c3ccc(OC)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262890 117835 0 None -1 2 Mouse 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 408 5 0 5 2.5 COC(=O)c1ccc(C(=O)N2CCN(C(=O)/C=C/c3ccc(OC)cc3)CC2)cc1 10.1021/jm4019355
90655990 117836 0 None 1 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 392 4 0 4 2.6 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc4c(c3)CCO4)CC2)cc1 10.1021/jm4019355
CHEMBL3262891 117836 0 None 1 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 392 4 0 4 2.6 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc4c(c3)CCO4)CC2)cc1 10.1021/jm4019355
86579982 117835 0 None -1 2 Mouse 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 408 5 0 5 2.5 COC(=O)c1ccc(C(=O)N2CCN(C(=O)/C=C/c3ccc(OC)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262890 117835 0 None -1 2 Mouse 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 408 5 0 5 2.5 COC(=O)c1ccc(C(=O)N2CCN(C(=O)/C=C/c3ccc(OC)cc3)CC2)cc1 10.1021/jm4019355
2664154 127719 4 None - 1 Human 7.7 pIC50 = 7.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 392 4 0 3 2.5 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2ccc(F)cc2)CC1 nan
CHEMBL3560941 127719 4 None - 1 Human 7.7 pIC50 = 7.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 392 4 0 3 2.5 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2ccc(F)cc2)CC1 nan
73330411 127739 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 408 4 0 3 3.0 O=C(/C=C/c1ccc(Cl)cc1F)N1CCN(S(=O)(=O)c2ccccc2)CC1 nan
CHEMBL3561595 127739 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 408 4 0 3 3.0 O=C(/C=C/c1ccc(Cl)cc1F)N1CCN(S(=O)(=O)c2ccccc2)CC1 nan
73330425 127678 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 448 4 0 3 3.3 Cc1ccccc1/C=C/C(=O)N1CCN(S(=O)(=O)c2ccc(Br)cc2)CC1 nan
CHEMBL3559978 127678 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 448 4 0 3 3.3 Cc1ccccc1/C=C/C(=O)N1CCN(S(=O)(=O)c2ccc(Br)cc2)CC1 nan
86579902 117824 1 None 4 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 348 4 0 2 2.9 Cc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262880 117824 1 None 4 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 348 4 0 2 2.9 Cc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1 10.1021/jm4019355
86579981 117833 0 None 1 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 393 5 0 4 2.8 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(N(C)C)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262889 117833 0 None 1 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 393 5 0 4 2.8 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(N(C)C)cc3)CC2)cc1 10.1021/jm4019355
86579902 117824 1 None 4 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 348 4 0 2 2.9 Cc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262880 117824 1 None 4 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 348 4 0 2 2.9 Cc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1 10.1021/jm4019355
86579981 117833 0 None 1 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 393 5 0 4 2.8 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(N(C)C)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262889 117833 0 None 1 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 393 5 0 4 2.8 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(N(C)C)cc3)CC2)cc1 10.1021/jm4019355
7750538 127673 3 None - 1 Human 7.7 pIC50 = 7.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 392 4 0 3 2.5 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2ccccc2F)CC1 nan
CHEMBL3559845 127673 3 None - 1 Human 7.7 pIC50 = 7.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 392 4 0 3 2.5 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2ccccc2F)CC1 nan
2678641 127738 3 None - 1 Human 7.7 pIC50 = 7.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 392 4 0 3 2.5 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2cccc(F)c2)CC1 nan
CHEMBL3561498 127738 3 None - 1 Human 7.7 pIC50 = 7.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 392 4 0 3 2.5 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2cccc(F)c2)CC1 nan
86579981 117833 0 None -1 2 Mouse 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 393 5 0 4 2.8 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(N(C)C)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262889 117833 0 None -1 2 Mouse 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 393 5 0 4 2.8 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(N(C)C)cc3)CC2)cc1 10.1021/jm4019355
1072081 117820 18 None 6 2 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 388 5 0 3 3.1 O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL3262876 117820 18 None 6 2 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 388 5 0 3 3.1 O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
73330409 127696 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 350 5 0 2 3.4 CCCCN1CCN(C(=O)/C=C/c2ccc(Br)cc2)CC1 nan
CHEMBL3560464 127696 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 350 5 0 2 3.4 CCCCN1CCN(C(=O)/C=C/c2ccc(Br)cc2)CC1 nan
73330398 127701 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 420 4 0 2 4.1 O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2cc(F)cc(F)c2)CC1 nan
CHEMBL3560573 127701 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 420 4 0 2 4.1 O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2cc(F)cc(F)c2)CC1 nan
73330410 127745 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 350 4 0 2 3.4 CCC(C)N1CCN(C(=O)/C=C/c2ccc(Br)cc2)CC1 nan
CHEMBL3561798 127745 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 350 4 0 2 3.4 CCC(C)N1CCN(C(=O)/C=C/c2ccc(Br)cc2)CC1 nan
73330406 127718 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 402 4 0 2 3.9 O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2cccc(F)c2)CC1 nan
CHEMBL3560897 127718 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 402 4 0 2 3.9 O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2cccc(F)c2)CC1 nan
1220338 66060 8 None - 1 Human 8.6 pIC50 = 8.6 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 384 4 0 2 3.8 O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2ccccc2)CC1 nan
CHEMBL1704801 66060 8 None - 1 Human 8.6 pIC50 = 8.6 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 384 4 0 2 3.8 O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2ccccc2)CC1 nan
86579981 117833 0 None -1 2 Mouse 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 393 5 0 4 2.8 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(N(C)C)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262889 117833 0 None -1 2 Mouse 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 393 5 0 4 2.8 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(N(C)C)cc3)CC2)cc1 10.1021/jm4019355
86579900 117823 0 None 1 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 412 4 0 2 3.4 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL3262879 117823 0 None 1 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 412 4 0 2 3.4 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
86579984 117837 0 None -1 2 Mouse 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 398 4 0 3 3.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(Cl)c(C)c3)CC2)cc1 10.1021/jm4019355
CHEMBL3262892 117837 0 None -1 2 Mouse 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 398 4 0 3 3.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(Cl)c(C)c3)CC2)cc1 10.1021/jm4019355
1072081 117820 18 None -6 2 Mouse 6.7 pIC50 = 6.7 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 388 5 0 3 3.1 O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL3262876 117820 18 None -6 2 Mouse 6.7 pIC50 = 6.7 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 388 5 0 3 3.1 O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
86579937 117825 1 None -7 2 Mouse 6.7 pIC50 = 6.7 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 5 0 3 2.6 COc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262881 117825 1 None -7 2 Mouse 6.7 pIC50 = 6.7 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 5 0 3 2.6 COc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1 10.1021/jm4019355
86579937 117825 1 None -7 2 Mouse 6.7 pIC50 = 6.7 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 5 0 3 2.6 COc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262881 117825 1 None -7 2 Mouse 6.7 pIC50 = 6.7 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 5 0 3 2.6 COc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1 10.1021/jm4019355
86579900 117823 0 None 1 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 412 4 0 2 3.4 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL3262879 117823 0 None 1 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 412 4 0 2 3.4 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
86579984 117837 0 None -1 2 Mouse 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 398 4 0 3 3.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(Cl)c(C)c3)CC2)cc1 10.1021/jm4019355
CHEMBL3262892 117837 0 None -1 2 Mouse 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 398 4 0 3 3.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(Cl)c(C)c3)CC2)cc1 10.1021/jm4019355
2673966 127702 4 None - 1 Human 7.7 pIC50 = 7.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 424 4 0 3 3.5 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1 nan
CHEMBL3560607 127702 4 None - 1 Human 7.7 pIC50 = 7.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 424 4 0 3 3.5 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1 nan
5721584 128078 8 None - 1 Human 7.7 pIC50 = 7.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 324 4 0 2 3.2 O=C(/C=C/c1ccccc1)N1CCN(Cc2ccc(F)cc2)CC1 nan
CHEMBL3561640 128078 8 None - 1 Human 7.7 pIC50 = 7.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 324 4 0 2 3.2 O=C(/C=C/c1ccccc1)N1CCN(Cc2ccc(F)cc2)CC1 nan
CHEMBL3580443 128078 8 None - 1 Human 7.7 pIC50 = 7.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 324 4 0 2 3.2 O=C(/C=C/c1ccccc1)N1CCN(Cc2ccc(F)cc2)CC1 nan
26204394 127740 1 None - 1 Human 7.7 pIC50 = 7.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 442 4 0 3 3.7 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2cc(Cl)ccc2Cl)CC1 nan
CHEMBL3561698 127740 1 None - 1 Human 7.7 pIC50 = 7.7 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 442 4 0 3 3.7 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2cc(Cl)ccc2Cl)CC1 nan
90655991 117839 0 None -1 2 Mouse 7.6 pIC50 = 7.6 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 396 3 0 3 3.3 O=C(/C=C/c1ccc(Cl)cc1)N1CCN(C(=O)c2ccc3c(c2)CCO3)CC1 10.1021/jm4019355
CHEMBL3262894 117839 0 None -1 2 Mouse 7.6 pIC50 = 7.6 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 396 3 0 3 3.3 O=C(/C=C/c1ccc(Cl)cc1)N1CCN(C(=O)c2ccc3c(c2)CCO3)CC1 10.1021/jm4019355
90655991 117839 0 None -1 2 Mouse 7.6 pIC50 = 7.6 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 396 3 0 3 3.3 O=C(/C=C/c1ccc(Cl)cc1)N1CCN(C(=O)c2ccc3c(c2)CCO3)CC1 10.1021/jm4019355
CHEMBL3262894 117839 0 None -1 2 Mouse 7.6 pIC50 = 7.6 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 396 3 0 3 3.3 O=C(/C=C/c1ccc(Cl)cc1)N1CCN(C(=O)c2ccc3c(c2)CCO3)CC1 10.1021/jm4019355
86579938 117826 1 None 1 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 402 4 0 2 3.9 O=C(/C=C/c1ccc(Cl)c(Cl)c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL3262882 117826 1 None 1 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 402 4 0 2 3.9 O=C(/C=C/c1ccc(Cl)c(Cl)c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
86579938 117826 1 None 1 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 402 4 0 2 3.9 O=C(/C=C/c1ccc(Cl)c(Cl)c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL3262882 117826 1 None 1 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 402 4 0 2 3.9 O=C(/C=C/c1ccc(Cl)c(Cl)c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
71295875 127747 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 416 6 0 3 3.3 CCCc1ccc(S(=O)(=O)N2CCN(C(=O)/C=C/c3ccc(F)cc3)CC2)cc1 nan
CHEMBL3561833 127747 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 416 6 0 3 3.3 CCCc1ccc(S(=O)(=O)N2CCN(C(=O)/C=C/c3ccc(F)cc3)CC2)cc1 nan
2677523 127714 1 None - 1 Human 7.6 pIC50 = 7.6 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 416 5 0 3 3.5 CC(C)c1ccc(S(=O)(=O)N2CCN(C(=O)/C=C/c3ccc(F)cc3)CC2)cc1 nan
CHEMBL3560877 127714 1 None - 1 Human 7.6 pIC50 = 7.6 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 416 5 0 3 3.5 CC(C)c1ccc(S(=O)(=O)N2CCN(C(=O)/C=C/c3ccc(F)cc3)CC2)cc1 nan
26867513 127722 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 452 4 0 3 3.1 O=C(/C=C/c1ccccc1F)N1CCN(S(=O)(=O)c2ccc(Br)cc2)CC1 nan
CHEMBL3561130 127722 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 452 4 0 3 3.1 O=C(/C=C/c1ccccc1F)N1CCN(S(=O)(=O)c2ccc(Br)cc2)CC1 nan
86580332 117821 1 None 3 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 416 5 0 3 2.7 O=C(COc1ccc(Br)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL3262877 117821 1 None 3 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 416 5 0 3 2.7 O=C(COc1ccc(Br)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
86580332 117821 1 None 3 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 416 5 0 3 2.7 O=C(COc1ccc(Br)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL3262877 117821 1 None 3 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 416 5 0 3 2.7 O=C(COc1ccc(Br)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
9299233 127682 4 None - 1 Human 7.5 pIC50 = 7.5 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 388 5 0 3 2.5 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)Cc2ccccc2)CC1 nan
CHEMBL3560082 127682 4 None - 1 Human 7.5 pIC50 = 7.5 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 388 5 0 3 2.5 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)Cc2ccccc2)CC1 nan
73330412 127684 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 442 4 2 4 1.1 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)c2cccc(B(O)O)c2)CC1 nan
CHEMBL3560195 127684 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 442 4 2 4 1.1 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)c2cccc(B(O)O)c2)CC1 nan
73330416 127687 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 402 4 0 2 3.9 O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2ccccc2F)CC1 nan
CHEMBL3560274 127687 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 402 4 0 2 3.9 O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2ccccc2F)CC1 nan
86579937 117825 1 None 7 2 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 5 0 3 2.6 COc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262881 117825 1 None 7 2 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 5 0 3 2.6 COc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1 10.1021/jm4019355
86579900 117823 0 None -1 2 Mouse 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 412 4 0 2 3.4 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL3262879 117823 0 None -1 2 Mouse 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 412 4 0 2 3.4 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
90655990 117836 0 None -1 2 Mouse 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 392 4 0 4 2.6 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc4c(c3)CCO4)CC2)cc1 10.1021/jm4019355
CHEMBL3262891 117836 0 None -1 2 Mouse 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 392 4 0 4 2.6 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc4c(c3)CCO4)CC2)cc1 10.1021/jm4019355
86579937 117825 1 None 7 2 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 5 0 3 2.6 COc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262881 117825 1 None 7 2 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 5 0 3 2.6 COc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1 10.1021/jm4019355
86579900 117823 0 None -1 2 Mouse 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 412 4 0 2 3.4 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL3262879 117823 0 None -1 2 Mouse 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 412 4 0 2 3.4 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
90655990 117836 0 None -1 2 Mouse 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 392 4 0 4 2.6 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc4c(c3)CCO4)CC2)cc1 10.1021/jm4019355
CHEMBL3262891 117836 0 None -1 2 Mouse 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 392 4 0 4 2.6 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc4c(c3)CCO4)CC2)cc1 10.1021/jm4019355
86579940 117828 0 None 2 2 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 4 0 3 3.0 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3cccc(C)c3)CC2)cc1 10.1021/jm4019355
CHEMBL3262884 117828 0 None 2 2 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 4 0 3 3.0 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3cccc(C)c3)CC2)cc1 10.1021/jm4019355
86579897 117822 1 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 366 5 0 3 2.6 Cc1ccc(OCC(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1C 10.1021/jm4019355
CHEMBL3262878 117822 1 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 366 5 0 3 2.6 Cc1ccc(OCC(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1C 10.1021/jm4019355
86579897 117822 1 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 366 5 0 3 2.6 Cc1ccc(OCC(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1C 10.1021/jm4019355
CHEMBL3262878 117822 1 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 366 5 0 3 2.6 Cc1ccc(OCC(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1C 10.1021/jm4019355
71295884 127712 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 402 6 0 3 2.6 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)CCc2ccccc2)CC1 nan
CHEMBL3560820 127712 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 402 6 0 3 2.6 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)CCc2ccccc2)CC1 nan
26867573 127748 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 452 4 0 3 3.1 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2ccc(Br)cc2)CC1 nan
CHEMBL3561859 127748 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 452 4 0 3 3.1 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2ccc(Br)cc2)CC1 nan
2674674 58010 7 None - 1 Human 8.5 pIC50 = 8.5 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 400 5 0 3 3.0 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)/C=C/c2ccccc2)CC1 nan
CHEMBL1580410 58010 7 None - 1 Human 8.5 pIC50 = 8.5 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 400 5 0 3 3.0 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)/C=C/c2ccccc2)CC1 nan
73330404 127693 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 444 6 0 4 3.8 COc1cc(CN2CCN(C(=O)/C=C/c3ccc(Br)cc3)CC2)cc(OC)c1 nan
CHEMBL3560415 127693 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 444 6 0 4 3.8 COc1cc(CN2CCN(C(=O)/C=C/c3ccc(Br)cc3)CC2)cc(OC)c1 nan
1072066 27076 15 None 3 2 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 372 5 0 3 2.6 O=C(COc1ccc(Cl)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL1305842 27076 15 None 3 2 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 372 5 0 3 2.6 O=C(COc1ccc(Cl)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
86579940 117828 0 None 2 2 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 4 0 3 3.0 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3cccc(C)c3)CC2)cc1 10.1021/jm4019355
CHEMBL3262884 117828 0 None 2 2 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 4 0 3 3.0 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3cccc(C)c3)CC2)cc1 10.1021/jm4019355
73330408 127750 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 502 4 0 3 4.0 O=C(/C=C/c1ccccc1C(F)(F)F)N1CCN(S(=O)(=O)c2ccc(Br)cc2)CC1 nan
CHEMBL3561867 127750 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 502 4 0 3 4.0 O=C(/C=C/c1ccccc1C(F)(F)F)N1CCN(S(=O)(=O)c2ccc(Br)cc2)CC1 nan
36294314 117832 1 None 1 2 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 380 5 0 4 2.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(OC)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262888 117832 1 None 1 2 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 380 5 0 4 2.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(OC)cc3)CC2)cc1 10.1021/jm4019355
36294314 117832 1 None 1 2 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 380 5 0 4 2.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(OC)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262888 117832 1 None 1 2 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 380 5 0 4 2.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(OC)cc3)CC2)cc1 10.1021/jm4019355
1072066 27076 15 None 3 2 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 372 5 0 3 2.6 O=C(COc1ccc(Cl)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL1305842 27076 15 None 3 2 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 372 5 0 3 2.6 O=C(COc1ccc(Cl)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
39572558 117831 1 None 1 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 4 0 3 3.0 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262887 117831 1 None 1 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 4 0 3 3.0 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C)cc3)CC2)cc1 10.1021/jm4019355
36511613 127690 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 390 3 0 2 3.3 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)C2CCCC2)CC1 nan
CHEMBL3560365 127690 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 390 3 0 2 3.3 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)C2CCCC2)CC1 nan
39572558 117831 1 None 1 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 4 0 3 3.0 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262887 117831 1 None 1 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 4 0 3 3.0 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C)cc3)CC2)cc1 10.1021/jm4019355
1072081 117820 18 None -6 2 Mouse 6.4 pIC50 = 6.4 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 388 5 0 3 3.1 O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL3262876 117820 18 None -6 2 Mouse 6.4 pIC50 = 6.4 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 388 5 0 3 3.1 O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
86579985 117838 0 None 1 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 378 4 0 3 3.3 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C)c(C)c3)CC2)cc1 10.1021/jm4019355
CHEMBL3262893 117838 0 None 1 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 378 4 0 3 3.3 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C)c(C)c3)CC2)cc1 10.1021/jm4019355
86579938 117826 1 None -1 2 Mouse 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 402 4 0 2 3.9 O=C(/C=C/c1ccc(Cl)c(Cl)c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL3262882 117826 1 None -1 2 Mouse 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 402 4 0 2 3.9 O=C(/C=C/c1ccc(Cl)c(Cl)c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
86579897 117822 1 None -1 2 Mouse 5.4 pIC50 = 5.4 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 366 5 0 3 2.6 Cc1ccc(OCC(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1C 10.1021/jm4019355
CHEMBL3262878 117822 1 None -1 2 Mouse 5.4 pIC50 = 5.4 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 366 5 0 3 2.6 Cc1ccc(OCC(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1C 10.1021/jm4019355
86579897 117822 1 None -1 2 Mouse 5.4 pIC50 = 5.4 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 366 5 0 3 2.6 Cc1ccc(OCC(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1C 10.1021/jm4019355
CHEMBL3262878 117822 1 None -1 2 Mouse 5.4 pIC50 = 5.4 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 366 5 0 3 2.6 Cc1ccc(OCC(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1C 10.1021/jm4019355
86579985 117838 0 None 1 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 378 4 0 3 3.3 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C)c(C)c3)CC2)cc1 10.1021/jm4019355
CHEMBL3262893 117838 0 None 1 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 378 4 0 3 3.3 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C)c(C)c3)CC2)cc1 10.1021/jm4019355
86579938 117826 1 None -1 2 Mouse 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 402 4 0 2 3.9 O=C(/C=C/c1ccc(Cl)c(Cl)c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL3262882 117826 1 None -1 2 Mouse 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 402 4 0 2 3.9 O=C(/C=C/c1ccc(Cl)c(Cl)c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
86579939 117827 0 None -2 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 366 4 0 2 3.1 Cc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1F 10.1021/jm4019355
CHEMBL3262883 117827 0 None -2 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 366 4 0 2 3.1 Cc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1F 10.1021/jm4019355
86579939 117827 0 None -2 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 366 4 0 2 3.1 Cc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1F 10.1021/jm4019355
CHEMBL3262883 117827 0 None -2 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 366 4 0 2 3.1 Cc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1F 10.1021/jm4019355
73330420 127685 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 480 4 0 3 4.8 CC(C)(C)c1ccc(S(=O)(=O)N2CCN(C(=O)/C=C/c3ccc(Cl)c(Cl)c3)CC2)cc1 nan
CHEMBL3560209 127685 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 480 4 0 3 4.8 CC(C)(C)c1ccc(S(=O)(=O)N2CCN(C(=O)/C=C/c3ccc(Cl)c(Cl)c3)CC2)cc1 nan
19325390 127751 2 None - 1 Human 6.3 pIC50 = 6.3 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 392 3 0 2 4.1 O=C(c1ccc(Br)cc1)N1CCN(Cc2ccc(Cl)cc2)CC1 nan
CHEMBL3561875 127751 2 None - 1 Human 6.3 pIC50 = 6.3 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 392 3 0 2 4.1 O=C(c1ccc(Br)cc1)N1CCN(Cc2ccc(Cl)cc2)CC1 nan
7942116 127700 3 None - 1 Human 7.3 pIC50 = 7.3 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 399 4 0 4 2.2 N#Cc1ccccc1S(=O)(=O)N1CCN(C(=O)/C=C/c2ccc(F)cc2)CC1 nan
CHEMBL3560541 127700 3 None - 1 Human 7.3 pIC50 = 7.3 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 399 4 0 4 2.2 N#Cc1ccccc1S(=O)(=O)N1CCN(C(=O)/C=C/c2ccc(F)cc2)CC1 nan
71295864 127677 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 424 4 0 3 3.5 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2cccc3ccccc23)CC1 nan
CHEMBL3559902 127677 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 424 4 0 3 3.5 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2cccc3ccccc23)CC1 nan
90655992 117840 0 None 1 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 440 3 0 3 3.4 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)c2ccc3c(c2)CCO3)CC1 10.1021/jm4019355
CHEMBL3262895 117840 0 None 1 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 440 3 0 3 3.4 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)c2ccc3c(c2)CCO3)CC1 10.1021/jm4019355
90655992 117840 0 None 1 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 440 3 0 3 3.4 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)c2ccc3c(c2)CCO3)CC1 10.1021/jm4019355
CHEMBL3262895 117840 0 None 1 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 440 3 0 3 3.4 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)c2ccc3c(c2)CCO3)CC1 10.1021/jm4019355
73330426 127737 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 486 4 0 2 5.5 O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2ccc(Cl)cc2C(F)(F)F)CC1 nan
CHEMBL3561495 127737 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 486 4 0 2 5.5 O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2ccc(Cl)cc2C(F)(F)F)CC1 nan
2634560 127731 3 None - 1 Human 8.3 pIC50 = 8.3 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 408 4 0 3 3.0 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2ccc(Cl)cc2)CC1 nan
CHEMBL3561390 127731 3 None - 1 Human 8.3 pIC50 = 8.3 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 408 4 0 3 3.0 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2ccc(Cl)cc2)CC1 nan
73330407 127725 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 378 5 0 2 3.3 CCCCC(=O)N1CCN(C(=O)/C=C/c2ccc(Br)cc2)CC1 nan
CHEMBL3561208 127725 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 378 5 0 2 3.3 CCCCC(=O)N1CCN(C(=O)/C=C/c2ccc(Br)cc2)CC1 nan
73330418 127742 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 426 5 0 2 4.9 CC(C)c1ccc(CN2CCN(C(=O)/C=C/c3ccc(Br)cc3)CC2)cc1 nan
CHEMBL3561719 127742 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 426 5 0 2 4.9 CC(C)c1ccc(CN2CCN(C(=O)/C=C/c3ccc(Br)cc3)CC2)cc1 nan
86579985 117838 0 None -1 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 378 4 0 3 3.3 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C)c(C)c3)CC2)cc1 10.1021/jm4019355
CHEMBL3262893 117838 0 None -1 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 378 4 0 3 3.3 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C)c(C)c3)CC2)cc1 10.1021/jm4019355
71295910 127726 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 404 5 0 4 2.4 COc1cccc(S(=O)(=O)N2CCN(C(=O)/C=C/c3ccc(F)cc3)CC2)c1 nan
CHEMBL3561230 127726 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 404 5 0 4 2.4 COc1cccc(S(=O)(=O)N2CCN(C(=O)/C=C/c3ccc(F)cc3)CC2)c1 nan
86579985 117838 0 None -1 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 378 4 0 3 3.3 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C)c(C)c3)CC2)cc1 10.1021/jm4019355
CHEMBL3262893 117838 0 None -1 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 378 4 0 3 3.3 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C)c(C)c3)CC2)cc1 10.1021/jm4019355
39572558 117831 1 None -1 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 4 0 3 3.0 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262887 117831 1 None -1 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 4 0 3 3.0 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C)cc3)CC2)cc1 10.1021/jm4019355
36294314 117832 1 None -1 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 380 5 0 4 2.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(OC)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262888 117832 1 None -1 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 380 5 0 4 2.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(OC)cc3)CC2)cc1 10.1021/jm4019355
36294314 117832 1 None -1 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 380 5 0 4 2.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(OC)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262888 117832 1 None -1 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 380 5 0 4 2.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(OC)cc3)CC2)cc1 10.1021/jm4019355
90655992 117840 0 None -1 2 Mouse 8.2 pIC50 = 8.2 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 440 3 0 3 3.4 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)c2ccc3c(c2)CCO3)CC1 10.1021/jm4019355
CHEMBL3262895 117840 0 None -1 2 Mouse 8.2 pIC50 = 8.2 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 440 3 0 3 3.4 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)c2ccc3c(c2)CCO3)CC1 10.1021/jm4019355
90655992 117840 0 None -1 2 Mouse 8.2 pIC50 = 8.2 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 440 3 0 3 3.4 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)c2ccc3c(c2)CCO3)CC1 10.1021/jm4019355
CHEMBL3262895 117840 0 None -1 2 Mouse 8.2 pIC50 = 8.2 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 440 3 0 3 3.4 O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)c2ccc3c(c2)CCO3)CC1 10.1021/jm4019355
73169083 127688 26 None - 1 Human 8.2 pIC50 = 8.2 Functional
PubChem BioAssay. Dose-response characterization of small molecule antagonists of the EBI2 receptor via a chemotaxis assay. (Class of assay: confirmatory) PubChem BioAssay. Dose-response characterization of small molecule antagonists of the EBI2 receptor via a chemotaxis assay. (Class of assay: confirmatory)
ChEMBL 418 4 0 2 4.5 O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2ccc(Cl)cc2)CC1 nan
CHEMBL3560331 127688 26 None - 1 Human 8.2 pIC50 = 8.2 Functional
PubChem BioAssay. Dose-response characterization of small molecule antagonists of the EBI2 receptor via a chemotaxis assay. (Class of assay: confirmatory) PubChem BioAssay. Dose-response characterization of small molecule antagonists of the EBI2 receptor via a chemotaxis assay. (Class of assay: confirmatory)
ChEMBL 418 4 0 2 4.5 O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2ccc(Cl)cc2)CC1 nan
73330417 127679 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 412 4 0 2 4.4 Cc1cc(C)cc(CN2CCN(C(=O)/C=C/c3ccc(Br)cc3)CC2)c1 nan
CHEMBL3559986 127679 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 412 4 0 2 4.4 Cc1cc(C)cc(CN2CCN(C(=O)/C=C/c3ccc(Br)cc3)CC2)c1 nan
2674674 58010 7 None - 1 Human 8.2 pIC50 = 8.2 Functional
PubChem BioAssay. Dose-response confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay. (Class of assay: confirmatory) PubChem BioAssay. Dose-response confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay. (Class of assay: confirmatory)
ChEMBL 400 5 0 3 3.0 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)/C=C/c2ccccc2)CC1 nan
CHEMBL1580410 58010 7 None - 1 Human 8.2 pIC50 = 8.2 Functional
PubChem BioAssay. Dose-response confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay. (Class of assay: confirmatory) PubChem BioAssay. Dose-response confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay. (Class of assay: confirmatory)
ChEMBL 400 5 0 3 3.0 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)/C=C/c2ccccc2)CC1 nan
6258671 55445 6 None - 1 Human 6.2 pIC50 = 6.2 Functional
PubChem BioAssay. Dose-response confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay. (Class of assay: confirmatory) PubChem BioAssay. Dose-response confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay. (Class of assay: confirmatory)
ChEMBL 374 4 0 3 2.4 O=C(/C=C/c1ccccc1)N1CCN(S(=O)(=O)c2ccc(F)cc2)CC1 nan
CHEMBL1557734 55445 6 None - 1 Human 6.2 pIC50 = 6.2 Functional
PubChem BioAssay. Dose-response confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay. (Class of assay: confirmatory) PubChem BioAssay. Dose-response confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay. (Class of assay: confirmatory)
ChEMBL 374 4 0 3 2.4 O=C(/C=C/c1ccccc1)N1CCN(S(=O)(=O)c2ccc(F)cc2)CC1 nan
39572558 117831 1 None -1 2 Mouse 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 4 0 3 3.0 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262887 117831 1 None -1 2 Mouse 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 4 0 3 3.0 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C)cc3)CC2)cc1 10.1021/jm4019355
73330400 127676 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 530 4 0 3 3.9 O=C(/C=C/c1ccc(Br)cc1F)N1CCN(S(=O)(=O)c2ccc(Br)cc2)CC1 nan
CHEMBL3559896 127676 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 530 4 0 3 3.9 O=C(/C=C/c1ccc(Br)cc1F)N1CCN(S(=O)(=O)c2ccc(Br)cc2)CC1 nan
86579942 117830 0 None 1 2 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(Br)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262886 117830 0 None 1 2 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(Br)cc3)CC2)cc1 10.1021/jm4019355
13052 9596 56 None 4 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.1 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysisAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.1 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysis
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
36295259 9596 56 None 4 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.1 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysisAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.1 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysis
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
CHEMBL3262896 9596 56 None 4 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.1 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysisAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.1 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysis
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
13052 9596 56 None 4 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.1 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysisAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.1 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysis
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
36295259 9596 56 None 4 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.1 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysisAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.1 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysis
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
CHEMBL3262896 9596 56 None 4 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.1 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysisAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.1 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysis
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
2634530 127680 6 None - 1 Human 8.1 pIC50 = 8.1 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 388 4 0 3 2.7 Cc1ccc(S(=O)(=O)N2CCN(C(=O)/C=C/c3ccc(F)cc3)CC2)cc1 nan
CHEMBL3559987 127680 6 None - 1 Human 8.1 pIC50 = 8.1 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 388 4 0 3 2.7 Cc1ccc(S(=O)(=O)N2CCN(C(=O)/C=C/c3ccc(F)cc3)CC2)cc1 nan
86579940 117828 0 None -2 2 Mouse 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 4 0 3 3.0 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3cccc(C)c3)CC2)cc1 10.1021/jm4019355
CHEMBL3262884 117828 0 None -2 2 Mouse 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 4 0 3 3.0 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3cccc(C)c3)CC2)cc1 10.1021/jm4019355
86579942 117830 0 None 1 2 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(Br)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262886 117830 0 None 1 2 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(Br)cc3)CC2)cc1 10.1021/jm4019355
73330395 127717 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 530 4 0 3 3.9 O=C(/C=C/c1cc(Br)ccc1F)N1CCN(S(=O)(=O)c2ccc(Br)cc2)CC1 nan
CHEMBL3560891 127717 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 530 4 0 3 3.9 O=C(/C=C/c1cc(Br)ccc1F)N1CCN(S(=O)(=O)c2ccc(Br)cc2)CC1 nan
86579942 117830 0 None -1 2 Mouse 7.1 pIC50 = 7.1 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(Br)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262886 117830 0 None -1 2 Mouse 7.1 pIC50 = 7.1 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(Br)cc3)CC2)cc1 10.1021/jm4019355
32268755 127699 4 None - 1 Human 8.1 pIC50 = 8.1 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 452 4 0 3 3.1 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2ccccc2Br)CC1 nan
CHEMBL3560529 127699 4 None - 1 Human 8.1 pIC50 = 8.1 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 452 4 0 3 3.1 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2ccccc2Br)CC1 nan
73330419 127735 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 436 4 0 2 4.6 O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2ccc(Cl)cc2F)CC1 nan
CHEMBL3561484 127735 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 436 4 0 2 4.6 O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2ccc(Cl)cc2F)CC1 nan
73330399 127743 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 470 4 0 2 5.0 O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2ccc(F)cc2C(F)(F)F)CC1 nan
CHEMBL3561739 127743 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 470 4 0 2 5.0 O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2ccc(F)cc2C(F)(F)F)CC1 nan
13052 9596 56 None 4 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.33 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysisAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.33 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysis
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
36295259 9596 56 None 4 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.33 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysisAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.33 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysis
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
CHEMBL3262896 9596 56 None 4 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.33 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysisAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.33 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysis
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
13052 9596 56 None 4 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.33 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysisAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.33 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysis
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
36295259 9596 56 None 4 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.33 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysisAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.33 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysis
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
CHEMBL3262896 9596 56 None 4 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.33 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysisAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.33 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysis
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
13052 9596 56 None 4 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced calcium release measured for 3 mins by FLIPR assayAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
36295259 9596 56 None 4 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced calcium release measured for 3 mins by FLIPR assayAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
CHEMBL3262896 9596 56 None 4 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced calcium release measured for 3 mins by FLIPR assayAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
86579941 117829 1 None 1 2 Mouse 7.1 pIC50 = 7.1 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 418 4 0 3 3.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C(F)(F)F)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262885 117829 1 None 1 2 Mouse 7.1 pIC50 = 7.1 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 418 4 0 3 3.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C(F)(F)F)cc3)CC2)cc1 10.1021/jm4019355
8924480 127698 1 None - 1 Human 7.1 pIC50 = 7.1 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 380 4 0 4 2.4 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2cccs2)CC1 nan
CHEMBL3560506 127698 1 None - 1 Human 7.1 pIC50 = 7.1 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 380 4 0 4 2.4 O=C(/C=C/c1ccc(F)cc1)N1CCN(S(=O)(=O)c2cccs2)CC1 nan
86579941 117829 1 None 1 2 Mouse 7.1 pIC50 = 7.1 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 418 4 0 3 3.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C(F)(F)F)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262885 117829 1 None 1 2 Mouse 7.1 pIC50 = 7.1 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 418 4 0 3 3.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C(F)(F)F)cc3)CC2)cc1 10.1021/jm4019355
1072081 117820 18 None 6 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced calcium release measured for 3 mins by FLIPR assayAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced calcium release measured for 3 mins by FLIPR assay
ChEMBL 388 5 0 3 3.1 O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL3262876 117820 18 None 6 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced calcium release measured for 3 mins by FLIPR assayAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced calcium release measured for 3 mins by FLIPR assay
ChEMBL 388 5 0 3 3.1 O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
86579940 117828 0 None -2 2 Mouse 7.1 pIC50 = 7.1 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 4 0 3 3.0 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3cccc(C)c3)CC2)cc1 10.1021/jm4019355
CHEMBL3262884 117828 0 None -2 2 Mouse 7.1 pIC50 = 7.1 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 364 4 0 3 3.0 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3cccc(C)c3)CC2)cc1 10.1021/jm4019355
13052 9596 56 None 4 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced calcium release measured for 3 mins by FLIPR assayAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
36295259 9596 56 None 4 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced calcium release measured for 3 mins by FLIPR assayAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
CHEMBL3262896 9596 56 None 4 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced calcium release measured for 3 mins by FLIPR assayAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
73330397 127671 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 440 4 0 2 5.1 CC(C)(C)c1ccc(CN2CCN(C(=O)/C=C/c3ccc(Br)cc3)CC2)cc1 nan
CHEMBL3559757 127671 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 440 4 0 2 5.1 CC(C)(C)c1ccc(CN2CCN(C(=O)/C=C/c3ccc(Br)cc3)CC2)cc1 nan
26867544 127721 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 464 5 0 4 3.0 COc1ccc(/C=C/C(=O)N2CCN(S(=O)(=O)c3ccc(Br)cc3)CC2)cc1 nan
CHEMBL3561084 127721 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 464 5 0 4 3.0 COc1ccc(/C=C/C(=O)N2CCN(S(=O)(=O)c3ccc(Br)cc3)CC2)cc1 nan
1072081 117820 18 None 6 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced calcium release measured for 3 mins by FLIPR assayAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced calcium release measured for 3 mins by FLIPR assay
ChEMBL 388 5 0 3 3.1 O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL3262876 117820 18 None 6 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced calcium release measured for 3 mins by FLIPR assayAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced calcium release measured for 3 mins by FLIPR assay
ChEMBL 388 5 0 3 3.1 O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
86579902 117824 1 None -4 2 Mouse 7.0 pIC50 = 7.0 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 348 4 0 2 2.9 Cc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262880 117824 1 None -4 2 Mouse 7.0 pIC50 = 7.0 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 348 4 0 2 2.9 Cc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1 10.1021/jm4019355
86579902 117824 1 None -4 2 Mouse 7.0 pIC50 = 7.0 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 348 4 0 2 2.9 Cc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262880 117824 1 None -4 2 Mouse 7.0 pIC50 = 7.0 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 348 4 0 2 2.9 Cc1ccc(/C=C/C(=O)N2CCN(C(=O)Cc3ccccc3)CC2)cc1 10.1021/jm4019355
86579942 117830 0 None -1 2 Mouse 7.0 pIC50 = 7.0 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(Br)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262886 117830 0 None -1 2 Mouse 7.0 pIC50 = 7.0 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 428 4 0 3 3.5 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(Br)cc3)CC2)cc1 10.1021/jm4019355
86579941 117829 1 None -1 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 418 4 0 3 3.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C(F)(F)F)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262885 117829 1 None -1 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 418 4 0 3 3.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C(F)(F)F)cc3)CC2)cc1 10.1021/jm4019355
1072066 27076 15 None -3 2 Mouse 6.0 pIC50 = 6.0 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 372 5 0 3 2.6 O=C(COc1ccc(Cl)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL1305842 27076 15 None -3 2 Mouse 6.0 pIC50 = 6.0 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 372 5 0 3 2.6 O=C(COc1ccc(Cl)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
1072066 27076 15 None -3 2 Mouse 6.0 pIC50 = 6.0 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 372 5 0 3 2.6 O=C(COc1ccc(Cl)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL1305842 27076 15 None -3 2 Mouse 6.0 pIC50 = 6.0 Functional
Antagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant mouse EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 372 5 0 3 2.6 O=C(COc1ccc(Cl)cc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
86579941 117829 1 None -1 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 418 4 0 3 3.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C(F)(F)F)cc3)CC2)cc1 10.1021/jm4019355
CHEMBL3262885 117829 1 None -1 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assayAntagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL 418 4 0 3 3.7 COc1ccc(/C=C/C(=O)N2CCN(C(=O)c3ccc(C(F)(F)F)cc3)CC2)cc1 10.1021/jm4019355
26756555 128076 2 None - 1 Human 7.0 pIC50 = 7.0 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 340 4 0 2 3.7 O=C(/C=C/c1ccccc1)N1CCN(Cc2ccc(Cl)cc2)CC1 nan
CHEMBL3561800 128076 2 None - 1 Human 7.0 pIC50 = 7.0 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 340 4 0 2 3.7 O=C(/C=C/c1ccccc1)N1CCN(Cc2ccc(Cl)cc2)CC1 nan
CHEMBL3580408 128076 2 None - 1 Human 7.0 pIC50 = 7.0 Functional
PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory)
ChEMBL 340 4 0 2 3.7 O=C(/C=C/c1ccccc1)N1CCN(Cc2ccc(Cl)cc2)CC1 nan
13051 9597 0 None 1 2 Human 5.7 pEC50 = 5.7 Functional
Measuring intracellular calcium release as detected using a FLIPR-type assay.Measuring intracellular calcium release as detected using a FLIPR-type assay.
Guide to Pharmacology 440 6 0 3 5.4 C1=CC(=CN=C1)CN(CC2=C(C=C(C=C2)Cl)Cl)S(=O)(=O)C3=CC=C(C=C3)Cl 24678947
13051 9597 0 None -1 2 Mouse 5.7 pEC50 = 5.7 Functional
Measuring intracellular calcium release as detected using a FLIPR-type assay.Measuring intracellular calcium release as detected using a FLIPR-type assay.
Guide to Pharmacology 440 6 0 3 5.4 C1=CC(=CN=C1)CN(CC2=C(C=C(C=C2)Cl)Cl)S(=O)(=O)C3=CC=C(C=C3)Cl 24678947
2726776 9597 0 None 1 2 Human 5.7 pEC50 = 5.7 Functional
Measuring intracellular calcium release as detected using a FLIPR-type assay.Measuring intracellular calcium release as detected using a FLIPR-type assay.
Guide to Pharmacology 440 6 0 3 5.4 C1=CC(=CN=C1)CN(CC2=C(C=C(C=C2)Cl)Cl)S(=O)(=O)C3=CC=C(C=C3)Cl 24678947
2726776 9597 0 None -1 2 Mouse 5.7 pEC50 = 5.7 Functional
Measuring intracellular calcium release as detected using a FLIPR-type assay.Measuring intracellular calcium release as detected using a FLIPR-type assay.
Guide to Pharmacology 440 6 0 3 5.4 C1=CC(=CN=C1)CN(CC2=C(C=C(C=C2)Cl)Cl)S(=O)(=O)C3=CC=C(C=C3)Cl 24678947
123976 6840 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 402 6 2 2 6.4 OC[C@@H](CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC=C2[C@]1(C)CC[C@@H](C2)O)C)C 21796211
2752 6840 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 402 6 2 2 6.4 OC[C@@H](CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC=C2[C@]1(C)CC[C@@H](C2)O)C)C 21796211
CHEMBL353882 6840 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 402 6 2 2 6.4 OC[C@@H](CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC=C2[C@]1(C)CC[C@@H](C2)O)C)C 21796211
4352 6967 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 402 5 2 2 6.4 CC(CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2[C@@H](O)C=C2[C@]1(C)CC[C@@H](C2)O)C)C 21796211
473141 6967 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 402 5 2 2 6.4 CC(CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2[C@@H](O)C=C2[C@]1(C)CC[C@@H](C2)O)C)C 21796211
CHEMBL497834 6967 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 402 5 2 2 6.4 CC(CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2[C@@H](O)C=C2[C@]1(C)CC[C@@H](C2)O)C)C 21796211
DB04706 6967 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 402 5 2 2 6.4 CC(CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2[C@@H](O)C=C2[C@]1(C)CC[C@@H](C2)O)C)C 21796211
2885 6839 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 402 5 2 2 6.5 O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)C1)C 21796211
65094 6839 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 402 5 2 2 6.5 O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)C1)C 21796211
CHEMBL169046 6839 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 402 5 2 2 6.5 O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)C1)C 21796211
DB04705 6839 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 402 5 2 2 6.5 O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)C1)C 21796211
107722 6958 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 402 5 2 2 6.4 CC(CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2[C@H](O)C=C2[C@]1(C)CC[C@@H](C2)O)C)C 21796211
4351 6958 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 402 5 2 2 6.4 CC(CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2[C@H](O)C=C2[C@]1(C)CC[C@@H](C2)O)C)C 21796211
CHEMBL497207 6958 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 402 5 2 2 6.4 CC(CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2[C@H](O)C=C2[C@]1(C)CC[C@@H](C2)O)C)C 21796211
4354 6966 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 418 6 3 3 5.3 OC[C@@H](CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2[C@@H](O)C=C2[C@]1(C)CC[C@@H](C2)O)C)C 21796211
52931518 6966 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 418 6 3 3 5.3 OC[C@@H](CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2[C@@H](O)C=C2[C@]1(C)CC[C@@H](C2)O)C)C 21796211
4355 6965 13 None - 1 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 21796211
473142 6965 13 None - 1 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 21796211
CHEMBL3311219 6965 13 None - 1 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 21796211
15907756 6955 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 418 6 3 3 5.3 OC[C@@H](CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2[C@H](O)C=C2[C@]1(C)CC[C@@H](C2)O)C)C 21796211
4353 6955 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 418 6 3 3 5.3 OC[C@@H](CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2[C@H](O)C=C2[C@]1(C)CC[C@@H](C2)O)C)C 21796211
11954197 6954 31 None 1 3 Human 9.0 pEC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 21796211
11954197 6954 31 None 1 3 Human 9.0 pEC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 21796212
4350 6954 31 None 1 3 Human 9.0 pEC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 21796211
4350 6954 31 None 1 3 Human 9.0 pEC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 21796212
CHEMBL4788348 6954 31 None 1 3 Human 9.0 pEC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 21796211
CHEMBL4788348 6954 31 None 1 3 Human 9.0 pEC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 21796212
13050 7857 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonism of β-arrestin recruitmentAntagonism of β-arrestin recruitment
Guide to Pharmacology 432 4 0 7 1.8 FC1(OC2=C(O1)C=CC(=C2)/C=C/C(N3CCN(C(C4=CN=C(OC)N=C4)=O)CC3)=O)F 38047891
169494480 7857 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonism of β-arrestin recruitmentAntagonism of β-arrestin recruitment
Guide to Pharmacology 432 4 0 7 1.8 FC1(OC2=C(O1)C=CC(=C2)/C=C/C(N3CCN(C(C4=CN=C(OC)N=C4)=O)CC3)=O)F 38047891
13052 9596 56 None -4 2 Mouse 7.8 pIC50 = 7.8 Functional
Antagonism of NIBR51-induced GPR183 activationAntagonism of NIBR51-induced GPR183 activation
Guide to Pharmacology 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 24678947
36295259 9596 56 None -4 2 Mouse 7.8 pIC50 = 7.8 Functional
Antagonism of NIBR51-induced GPR183 activationAntagonism of NIBR51-induced GPR183 activation
Guide to Pharmacology 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 24678947
CHEMBL3262896 9596 56 None -4 2 Mouse 7.8 pIC50 = 7.8 Functional
Antagonism of NIBR51-induced GPR183 activationAntagonism of NIBR51-induced GPR183 activation
Guide to Pharmacology 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 24678947
13052 9596 56 None 4 2 Human 8.0 pIC50 = 8.0 Functional
Antagonism of NIBR51-induced GPR183 activationAntagonism of NIBR51-induced GPR183 activation
Guide to Pharmacology 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 24678947
36295259 9596 56 None 4 2 Human 8.0 pIC50 = 8.0 Functional
Antagonism of NIBR51-induced GPR183 activationAntagonism of NIBR51-induced GPR183 activation
Guide to Pharmacology 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 24678947
CHEMBL3262896 9596 56 None 4 2 Human 8.0 pIC50 = 8.0 Functional
Antagonism of NIBR51-induced GPR183 activationAntagonism of NIBR51-induced GPR183 activation
Guide to Pharmacology 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 24678947
126843232 8666 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Determined in a CREB-based reporter assay in HEK293 cells transiently transfected with wild type hGPR183; measuring inhibition of GPR183 constitutive activity.Determined in a CREB-based reporter assay in HEK293 cells transiently transfected with wild type hGPR183; measuring inhibition of GPR183 constitutive activity.
Guide to Pharmacology 478 4 0 3 5.7 C1CN(CCC12CN(C(=O)O2)CC3=CC(=C(C=C3)Cl)Cl)C(=O)/C=C/C4=CC=C(C=C4)Cl 21673108
13053 8666 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Determined in a CREB-based reporter assay in HEK293 cells transiently transfected with wild type hGPR183; measuring inhibition of GPR183 constitutive activity.Determined in a CREB-based reporter assay in HEK293 cells transiently transfected with wild type hGPR183; measuring inhibition of GPR183 constitutive activity.
Guide to Pharmacology 478 4 0 3 5.7 C1CN(CCC12CN(C(=O)O2)CC3=CC(=C(C=C3)Cl)Cl)C(=O)/C=C/C4=CC=C(C=C4)Cl 21673108
11954197 6954 31 None 1 3 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 21796211
11954197 6954 31 None 1 3 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 21796212
4350 6954 31 None 1 3 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 21796211
4350 6954 31 None 1 3 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 21796212
CHEMBL4788348 6954 31 None 1 3 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 21796211
CHEMBL4788348 6954 31 None 1 3 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 21796212


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
162663790 188677 0 None - 0 Rat 9.0 pEC50 = 9.0 Binding
Agonist activity at Go2-q-coupled rat EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled rat EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 486 5 3 3 6.4 C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@]3(O)C(F)(F)F 10.1016/j.bmcl.2016.09.029
CHEMBL4779254 188677 0 None - 0 Rat 9.0 pEC50 = 9.0 Binding
Agonist activity at Go2-q-coupled rat EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled rat EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 486 5 3 3 6.4 C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@]3(O)C(F)(F)F 10.1016/j.bmcl.2016.09.029
11954197 6954 31 None - 0 Rat 8.9 pEC50 = 8.9 Binding
Agonist activity at Go2-q-coupled rat EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled rat EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 10.1016/j.bmcl.2016.09.029
4350 6954 31 None - 0 Rat 8.9 pEC50 = 8.9 Binding
Agonist activity at Go2-q-coupled rat EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled rat EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 10.1016/j.bmcl.2016.09.029
CHEMBL4788348 6954 31 None - 0 Rat 8.9 pEC50 = 8.9 Binding
Agonist activity at Go2-q-coupled rat EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled rat EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 418 5 3 3 5.5 O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C 10.1016/j.bmcl.2016.09.029
162656664 187636 0 None - 0 Rat 7.8 pEC50 = 7.8 Binding
Agonist activity at Go2-q-coupled rat EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled rat EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 486 5 3 3 6.4 C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@@]3(O)C(F)(F)F 10.1016/j.bmcl.2016.09.029
CHEMBL4757291 187636 0 None - 0 Rat 7.8 pEC50 = 7.8 Binding
Agonist activity at Go2-q-coupled rat EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled rat EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis
ChEMBL 486 5 3 3 6.4 C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@@]3(O)C(F)(F)F 10.1016/j.bmcl.2016.09.029
13052 9596 56 None - 0 Human 9.7 pIC50 = 9.7 Binding
Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysisAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
36295259 9596 56 None - 0 Human 9.7 pIC50 = 9.7 Binding
Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysisAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
CHEMBL3262896 9596 56 None - 0 Human 9.7 pIC50 = 9.7 Binding
Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysisAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
13052 9596 56 None - 0 Human 9.5 pIC50 = 9.5 Binding
Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysisAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
36295259 9596 56 None - 0 Human 9.5 pIC50 = 9.5 Binding
Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysisAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
CHEMBL3262896 9596 56 None - 0 Human 9.5 pIC50 = 9.5 Binding
Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysisAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis
ChEMBL 428 4 0 3 3.5 COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br 10.1021/jm4019355
1072081 117820 18 None - 0 Human 8.3 pIC50 = 8.3 Binding
Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysisAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis
ChEMBL 388 5 0 3 3.1 O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL3262876 117820 18 None - 0 Human 8.3 pIC50 = 8.3 Binding
Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysisAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis
ChEMBL 388 5 0 3 3.1 O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
1072081 117820 18 None - 0 Human 8.3 pIC50 = 8.3 Binding
Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysisAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis
ChEMBL 388 5 0 3 3.1 O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL3262876 117820 18 None - 0 Human 8.3 pIC50 = 8.3 Binding
Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysisAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis
ChEMBL 388 5 0 3 3.1 O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
1072081 117820 18 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]-7-alpha,25-OHC from recombinant human EBI2 receptor expressed in CHO cells after 10 mins by scintillation counting analysisDisplacement of [3H]-7-alpha,25-OHC from recombinant human EBI2 receptor expressed in CHO cells after 10 mins by scintillation counting analysis
ChEMBL 388 5 0 3 3.1 O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL3262876 117820 18 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]-7-alpha,25-OHC from recombinant human EBI2 receptor expressed in CHO cells after 10 mins by scintillation counting analysisDisplacement of [3H]-7-alpha,25-OHC from recombinant human EBI2 receptor expressed in CHO cells after 10 mins by scintillation counting analysis
ChEMBL 388 5 0 3 3.1 O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
1072081 117820 18 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]-7-alpha,25-OHC from recombinant human EBI2 receptor expressed in CHO cells after 10 mins by scintillation counting analysisDisplacement of [3H]-7-alpha,25-OHC from recombinant human EBI2 receptor expressed in CHO cells after 10 mins by scintillation counting analysis
ChEMBL 388 5 0 3 3.1 O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
CHEMBL3262876 117820 18 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]-7-alpha,25-OHC from recombinant human EBI2 receptor expressed in CHO cells after 10 mins by scintillation counting analysisDisplacement of [3H]-7-alpha,25-OHC from recombinant human EBI2 receptor expressed in CHO cells after 10 mins by scintillation counting analysis
ChEMBL 388 5 0 3 3.1 O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm4019355
126843232 8666 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Measuring inhibition of [<sup>35</sup>S]GTP&gamma;S binding to hGPR183 in cell membrane preparationsMeasuring inhibition of [<sup>35</sup>S]GTP&gamma;S binding to hGPR183 in cell membrane preparations
Guide to Pharmacology 478 4 0 3 5.7 C1CN(CCC12CN(C(=O)O2)CC3=CC(=C(C=C3)Cl)Cl)C(=O)/C=C/C4=CC=C(C=C4)Cl 21673108
13053 8666 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Measuring inhibition of [<sup>35</sup>S]GTP&gamma;S binding to hGPR183 in cell membrane preparationsMeasuring inhibition of [<sup>35</sup>S]GTP&gamma;S binding to hGPR183 in cell membrane preparations
Guide to Pharmacology 478 4 0 3 5.7 C1CN(CCC12CN(C(=O)O2)CC3=CC(=C(C=C3)Cl)Cl)C(=O)/C=C/C4=CC=C(C=C4)Cl 21673108