GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	56707820	2866	34	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Affinity Phenotypic Cellular interaction (FLIPR-TETRA assay (proton-mediated calcium mobilization in HEK293T cells)) EUB0000354a GPR68Affinity Phenotypic Cellular interaction (FLIPR-TETRA assay (proton-mediated calcium mobilization in HEK293T cells)) EUB0000354a GPR68	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	nan
	9155	2866	34	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Affinity Phenotypic Cellular interaction (FLIPR-TETRA assay (proton-mediated calcium mobilization in HEK293T cells)) EUB0000354a GPR68Affinity Phenotypic Cellular interaction (FLIPR-TETRA assay (proton-mediated calcium mobilization in HEK293T cells)) EUB0000354a GPR68	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	nan
	CHEMBL4548689	2866	34	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Affinity Phenotypic Cellular interaction (FLIPR-TETRA assay (proton-mediated calcium mobilization in HEK293T cells)) EUB0000354a GPR68Affinity Phenotypic Cellular interaction (FLIPR-TETRA assay (proton-mediated calcium mobilization in HEK293T cells)) EUB0000354a GPR68	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	nan
	10572	3099	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	31675498
	145996515	3099	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	31675498
	10571	789	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	31675498
	145996514	789	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	31675498
	10570	2924	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	31675498
	145996513	2924	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	31675498
	56707820	2866	34	None	-	1	Human	5.0	pKB	=	5.0	Functional	Allosteric ligand biochemical binding affinity in the presence of protons (H<sup>+</sup>. Affinity cannot be measured in the absence of endogenous ligand for this receptor.Allosteric ligand biochemical binding affinity in the presence of protons (H<sup>+</sup>. Affinity cannot be measured in the absence of endogenous ligand for this receptor.	Guide to Pharmacology	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	26550826
	9155	2866	34	None	-	1	Human	5.0	pKB	=	5.0	Functional	Allosteric ligand biochemical binding affinity in the presence of protons (H<sup>+</sup>. Affinity cannot be measured in the absence of endogenous ligand for this receptor.Allosteric ligand biochemical binding affinity in the presence of protons (H<sup>+</sup>. Affinity cannot be measured in the absence of endogenous ligand for this receptor.	Guide to Pharmacology	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	26550826
	CHEMBL4548689	2866	34	None	-	1	Human	5.0	pKB	=	5.0	Functional	Allosteric ligand biochemical binding affinity in the presence of protons (H<sup>+</sup>. Affinity cannot be measured in the absence of endogenous ligand for this receptor.Allosteric ligand biochemical binding affinity in the presence of protons (H<sup>+</sup>. Affinity cannot be measured in the absence of endogenous ligand for this receptor.	Guide to Pharmacology	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	26550826
	10440	2642	15	None	-4	3	Human	5.9	pKB	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	31298539
	139030523	2642	15	None	-4	3	Human	5.9	pKB	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	31298539
	CHEMBL4449712	2642	15	None	-4	3	Human	5.9	pKB	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	31298539

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI