Ligand source activities (1 row/activity)





Ligands Receptor Assay information Chemical information
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name
GPCRdb ID #Vendors Reference
ligand
Fold selectivity
(Potency)
# tested GPCRs
(Potency)
Species p-value
(-log)
Type Activity
Relation
Activity
Value
Assay Type Assay Description Source Mol
weight
Rot
Bonds
H don H acc LogP Smiles DOI
11212 165 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 237 8 2 2 3.4 CCCCCCCCCc1cc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
127045422 165 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 237 8 2 2 3.4 CCCCCCCCCc1cc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
CHEMBL3828298 165 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 237 8 2 2 3.4 CCCCCCCCCc1cc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
11212 165 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assayAgonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assay
ChEMBL 237 8 2 2 3.4 CCCCCCCCCc1cc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
127045422 165 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assayAgonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assay
ChEMBL 237 8 2 2 3.4 CCCCCCCCCc1cc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
CHEMBL3828298 165 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assayAgonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assay
ChEMBL 237 8 2 2 3.4 CCCCCCCCCc1cc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
11211 4090 26 None -2 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
1912564 4090 26 None -2 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827756 4090 26 None -2 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
11211 4090 26 None -2 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
1912564 4090 26 None -2 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827756 4090 26 None -2 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
54678947 22838 2 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 209 6 2 3 3.0 CCCCCCCc1cc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL13302 22838 2 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 209 6 2 3 3.0 CCCCCCCc1cc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
127044155 140619 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 223 7 2 3 3.4 CCCCCCCCc1cc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827638 140619 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 223 7 2 3 3.4 CCCCCCCCc1cc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
23646340 83905 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human GPR84 expressed in HEK293 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 60 mins by HTRF assayAgonist activity at human GPR84 expressed in HEK293 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 60 mins by HTRF assay
ChEMBL 252 7 2 4 3.1 CCCCCCCCC1=C(O)C(=O)C=C(O)C1=O 10.1021/acs.jmedchem.0c01378
CHEMBL221598 83905 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human GPR84 expressed in HEK293 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 60 mins by HTRF assayAgonist activity at human GPR84 expressed in HEK293 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 60 mins by HTRF assay
ChEMBL 252 7 2 4 3.1 CCCCCCCCC1=C(O)C(=O)C=C(O)C1=O 10.1021/acs.jmedchem.0c01378
11208 1395 108 None 2 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
3071 1395 108 None 2 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
CHEMBL446452 1395 108 None 2 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
DB11875 1395 108 None 2 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
137656606 159061 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 304 3 2 2 4.0 COC(=O)c1ccc2[nH]cc(Cc3c[nH]c4ccccc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4103279 159061 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 304 3 2 2 4.0 COC(=O)c1ccc2[nH]cc(Cc3c[nH]c4ccccc34)c2c1 10.1021/acs.jmedchem.6b01593
3893 2255 92 None -3 4 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
4642 2255 92 None -3 4 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
5534 2255 92 None -3 4 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
CHEMBL108766 2255 92 None -3 4 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
DB03017 2255 92 None -3 4 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
10354234 164 41 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as increase in myo-[3H]inositol phosphate accumulation measured after 2 hrs by topcount scintillation counting methodAgonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as increase in myo-[3H]inositol phosphate accumulation measured after 2 hrs by topcount scintillation counting method
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
5846 164 41 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as increase in myo-[3H]inositol phosphate accumulation measured after 2 hrs by topcount scintillation counting methodAgonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as increase in myo-[3H]inositol phosphate accumulation measured after 2 hrs by topcount scintillation counting method
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827832 164 41 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as increase in myo-[3H]inositol phosphate accumulation measured after 2 hrs by topcount scintillation counting methodAgonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as increase in myo-[3H]inositol phosphate accumulation measured after 2 hrs by topcount scintillation counting method
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
3893 2255 92 None -3 4 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
4642 2255 92 None -3 4 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
5534 2255 92 None -3 4 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
CHEMBL108766 2255 92 None -3 4 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
DB03017 2255 92 None -3 4 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
127044004 140643 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 290 7 2 5 3.4 Oc1cc(O)nc(SCCCCCc2ccccc2)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827935 140643 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 290 7 2 5 3.4 Oc1cc(O)nc(SCCCCCc2ccccc2)n1 10.1021/acsmedchemlett.6b00025
137658184 159204 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 350 2 2 0 5.8 Fc1cc2c(Cc3c[nH]c4cc(Cl)c(F)cc34)c[nH]c2cc1Cl 10.1021/acs.jmedchem.6b01593
CHEMBL4104992 159204 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 350 2 2 0 5.8 Fc1cc2c(Cc3c[nH]c4cc(Cl)c(F)cc34)c[nH]c2cc1Cl 10.1021/acs.jmedchem.6b01593
127044149 140610 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 224 7 2 4 2.8 CCCCCCCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827580 140610 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 224 7 2 4 2.8 CCCCCCCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
11208 1395 108 None 2 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by top-count liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by top-count liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
3071 1395 108 None 2 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by top-count liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by top-count liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
CHEMBL446452 1395 108 None 2 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by top-count liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by top-count liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
DB11875 1395 108 None 2 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by top-count liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by top-count liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
11208 1395 108 None 2 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
3071 1395 108 None 2 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
CHEMBL446452 1395 108 None 2 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
DB11875 1395 108 None 2 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
153309768 192228 0 None -5 2 Human 6.0 pEC50 = 6.0 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5179395 192228 0 None -5 2 Human 6.0 pEC50 = 6.0 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221639 192228 0 None -5 2 Human 6.0 pEC50 = 6.0 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
137635702 155506 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 282 2 2 0 4.5 Fc1cccc2c(Cc3c[nH]c4c(F)cccc34)c[nH]c12 10.1021/acs.jmedchem.6b01593
CHEMBL4062512 155506 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 282 2 2 0 4.5 Fc1cccc2c(Cc3c[nH]c4c(F)cccc34)c[nH]c12 10.1021/acs.jmedchem.6b01593
127045478 140689 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 368 16 2 5 6.5 CCCCCCCCCCCCCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3828578 140689 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 368 16 2 5 6.5 CCCCCCCCCCCCCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
137632827 155852 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 314 2 2 0 5.5 Clc1cccc2[nH]cc(Cc3c[nH]c4cccc(Cl)c34)c12 10.1021/acs.jmedchem.6b01593
CHEMBL4066454 155852 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 314 2 2 0 5.5 Clc1cccc2[nH]cc(Cc3c[nH]c4cccc(Cl)c34)c12 10.1021/acs.jmedchem.6b01593
11005 2654 100 None -1 3 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
2806 2654 100 None -1 3 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL111077 2654 100 None -1 3 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB08231 2654 100 None -1 3 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
137643701 157733 0 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.01 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.01 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4088884 157733 0 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.01 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.01 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
137643701 157733 0 None -2 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.0c01378
CHEMBL4088884 157733 0 None -2 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.0c01378
127043534 140624 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 312 12 2 5 4.9 CCCCCCCCCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827684 140624 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 312 12 2 5 4.9 CCCCCCCCCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
11210 3163 1 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assay
ChEMBL 265 4 3 3 1.4 Clc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.0c01378
146025748 3163 1 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assay
ChEMBL 265 4 3 3 1.4 Clc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.0c01378
CHEMBL4538049 3163 1 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assay
ChEMBL 265 4 3 3 1.4 Clc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.0c01378
127044143 140695 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 210 6 2 4 2.4 CCCCCCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3828708 140695 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 210 6 2 4 2.4 CCCCCCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
11211 4090 26 None 2 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
1912564 4090 26 None 2 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
CHEMBL3827756 4090 26 None 2 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
10354234 164 41 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
5846 164 41 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827832 164 41 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
11208 1395 108 None 2 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
3071 1395 108 None 2 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
CHEMBL446452 1395 108 None 2 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
DB11875 1395 108 None 2 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
5849 66 39 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCCCC(C(=O)O)O 10.1039/C7MD00130D
97783 66 39 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCCCC(C(=O)O)O 10.1039/C7MD00130D
CHEMBL4278254 66 39 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCCCC(C(=O)O)O 10.1039/C7MD00130D
5850 100 54 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human Gialpha-coupled GPR84 expressed in baculovirus infected sf9 insect cells assessed as induction of [35S]GTPgammaS incubated for 1 hr by liquid scintillation counting methodAgonist activity at human Gialpha-coupled GPR84 expressed in baculovirus infected sf9 insect cells assessed as induction of [35S]GTPgammaS incubated for 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.0c01378
94216 100 54 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human Gialpha-coupled GPR84 expressed in baculovirus infected sf9 insect cells assessed as induction of [35S]GTPgammaS incubated for 1 hr by liquid scintillation counting methodAgonist activity at human Gialpha-coupled GPR84 expressed in baculovirus infected sf9 insect cells assessed as induction of [35S]GTPgammaS incubated for 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.0c01378
CHEMBL4288936 100 54 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human Gialpha-coupled GPR84 expressed in baculovirus infected sf9 insect cells assessed as induction of [35S]GTPgammaS incubated for 1 hr by liquid scintillation counting methodAgonist activity at human Gialpha-coupled GPR84 expressed in baculovirus infected sf9 insect cells assessed as induction of [35S]GTPgammaS incubated for 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.0c01378
5850 100 54 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
94216 100 54 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
CHEMBL4288936 100 54 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
11211 4090 26 None -2 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
1912564 4090 26 None -2 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827756 4090 26 None -2 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
11211 4090 26 None -2 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
1912564 4090 26 None -2 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
CHEMBL3827756 4090 26 None -2 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
11211 4090 26 None -2 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assayAgonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
1912564 4090 26 None -2 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assayAgonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
CHEMBL3827756 4090 26 None -2 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assayAgonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
11005 2654 100 None -1 3 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
2806 2654 100 None -1 3 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
CHEMBL111077 2654 100 None -1 3 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
DB08231 2654 100 None -1 3 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
16064 170477 62 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCCC(O)CC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL4456892 170477 62 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCCC(O)CC(=O)O 10.1021/acs.jmedchem.9b01339
11211 4090 26 None -2 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
1912564 4090 26 None -2 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
CHEMBL3827756 4090 26 None -2 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
10354234 164 41 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
5846 164 41 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827832 164 41 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
5533 3880 100 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
8180 3880 100 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL108030 3880 100 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5288266 16265 37 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCC[C@@H](O)CC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL1232858 16265 37 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCC[C@@H](O)CC(=O)O 10.1021/acs.jmedchem.9b01339
137643701 157733 0 None 2 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.0c01378
CHEMBL4088884 157733 0 None 2 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.0c01378
153309768 192228 0 None -5 2 Human 5.8 pEC50 = 5.8 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5179395 192228 0 None -5 2 Human 5.8 pEC50 = 5.8 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221639 192228 0 None -5 2 Human 5.8 pEC50 = 5.8 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
137649817 156869 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 318 2 2 0 4.8 Fc1cc2[nH]cc(Cc3c[nH]c4cc(F)c(F)cc34)c2cc1F 10.1021/acs.jmedchem.6b01593
CHEMBL4078546 156869 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 318 2 2 0 4.8 Fc1cc2[nH]cc(Cc3c[nH]c4cc(F)c(F)cc34)c2cc1F 10.1021/acs.jmedchem.6b01593
102583156 158371 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 276 3 2 1 4.2 COc1ccc2[nH]cc(Cc3c[nH]c4ccccc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4095532 158371 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 276 3 2 1 4.2 COc1ccc2[nH]cc(Cc3c[nH]c4ccccc34)c2c1 10.1021/acs.jmedchem.6b01593
10354234 164 41 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.0c01378
5846 164 41 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.0c01378
CHEMBL3827832 164 41 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.0c01378
133081959 3164 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assay
ChEMBL 309 4 3 3 1.5 Brc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
9871 3164 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assay
ChEMBL 309 4 3 3 1.5 Brc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4444010 3164 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assay
ChEMBL 309 4 3 3 1.5 Brc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
11209 1522 87 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
3218 1522 87 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL221137 1522 87 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
135373094 1330 89 None 2 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
2969 1330 89 None 2 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5532 1330 89 None 2 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL107498 1330 89 None 2 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB03600 1330 89 None 2 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
79034 193536 93 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 11 2 2 3.0 O=C(O)CCCCCCCCCCCO 10.1039/C7MD00130D
CHEMBL55068 193536 93 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 11 2 2 3.0 O=C(O)CCCCCCCCCCCO 10.1039/C7MD00130D
127044148 140615 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 196 4 2 4 1.9 CC(C)CCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827606 140615 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 196 4 2 4 1.9 CC(C)CCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
11211 4090 26 None -2 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
1912564 4090 26 None -2 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827756 4090 26 None -2 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
127045479 140692 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 210 4 2 5 1.4 C#CCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3828642 140692 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 210 4 2 5 1.4 C#CCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
10171 1783 16 None - 1 Human 4.7 pEC50 = 4.7 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
71616860 1783 16 None - 1 Human 4.7 pEC50 = 4.7 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
CHEMBL3716365 1783 16 None - 1 Human 4.7 pEC50 = 4.7 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
DB15346 1783 16 None - 1 Human 4.7 pEC50 = 4.7 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
127043533 140632 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 242 7 2 5 3.0 CCCCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827763 140632 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 242 7 2 5 3.0 CCCCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
660705 38547 19 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 214 5 2 5 2.2 CCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL1466478 38547 19 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 214 5 2 5 2.2 CCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
135373094 1330 89 None 2 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
2969 1330 89 None 2 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5532 1330 89 None 2 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL107498 1330 89 None 2 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB03600 1330 89 None 2 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
11208 1395 108 None 2 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
3071 1395 108 None 2 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
CHEMBL446452 1395 108 None 2 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
DB11875 1395 108 None 2 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
127045477 140622 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 340 14 2 5 5.7 CCCCCCCCCCCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827657 140622 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 340 14 2 5 5.7 CCCCCCCCCCCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
11211 4090 26 None 2 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
1912564 4090 26 None 2 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
CHEMBL3827756 4090 26 None 2 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
13413723 140635 7 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 256 8 2 5 3.3 CCCCCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827862 140635 7 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 256 8 2 5 3.3 CCCCCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
137649231 156593 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 264 2 2 0 4.4 Fc1ccc2[nH]cc(Cc3c[nH]c4ccccc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4075099 156593 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 264 2 2 0 4.4 Fc1ccc2[nH]cc(Cc3c[nH]c4ccccc34)c2c1 10.1021/acs.jmedchem.6b01593
137643701 157733 0 None -2 2 Human 5.6 pEC50 = 5.6 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4088884 157733 0 None -2 2 Human 5.6 pEC50 = 5.6 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
127044463 140570 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 262 4 2 5 2.7 CCc1ccc(CSc2nc(O)cc(O)n2)cc1 10.1021/acsmedchemlett.6b00025
CHEMBL3827038 140570 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 262 4 2 5 2.7 CCc1ccc(CSc2nc(O)cc(O)n2)cc1 10.1021/acsmedchemlett.6b00025
11211 4090 26 None -2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
1912564 4090 26 None -2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
CHEMBL3827756 4090 26 None -2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
153309768 192228 0 None -5 2 Human 4.6 pEC50 = 4.6 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5179395 192228 0 None -5 2 Human 4.6 pEC50 = 4.6 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221639 192228 0 None -5 2 Human 4.6 pEC50 = 4.6 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
137643701 157733 0 None 2 2 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.0c01378
CHEMBL4088884 157733 0 None 2 2 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.0c01378
11208 1395 108 None 2 2 Human 5.5 pEC50 = 5.5 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
3071 1395 108 None 2 2 Human 5.5 pEC50 = 5.5 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
CHEMBL446452 1395 108 None 2 2 Human 5.5 pEC50 = 5.5 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
DB11875 1395 108 None 2 2 Human 5.5 pEC50 = 5.5 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
10171 1783 16 None - 1 Human 5.5 pEC50 = 5.5 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
71616860 1783 16 None - 1 Human 5.5 pEC50 = 5.5 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
CHEMBL3716365 1783 16 None - 1 Human 5.5 pEC50 = 5.5 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
DB15346 1783 16 None - 1 Human 5.5 pEC50 = 5.5 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
137643701 157733 0 None 2 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.0c01378
CHEMBL4088884 157733 0 None 2 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.0c01378
127044150 140648 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 238 7 2 4 3.4 CCCCCCCC(C)c1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3828004 140648 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 238 7 2 4 3.4 CCCCCCCC(C)c1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
11211 4090 26 None 2 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
1912564 4090 26 None 2 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
CHEMBL3827756 4090 26 None 2 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
135373094 1330 89 None 2 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at recombinant human N-terminally HA-tagged GPR84 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human N-terminally HA-tagged GPR84 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
2969 1330 89 None 2 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at recombinant human N-terminally HA-tagged GPR84 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human N-terminally HA-tagged GPR84 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5532 1330 89 None 2 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at recombinant human N-terminally HA-tagged GPR84 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human N-terminally HA-tagged GPR84 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL107498 1330 89 None 2 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at recombinant human N-terminally HA-tagged GPR84 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human N-terminally HA-tagged GPR84 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB03600 1330 89 None 2 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at recombinant human N-terminally HA-tagged GPR84 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human N-terminally HA-tagged GPR84 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
26612 99 70 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 188 8 2 2 2.2 CCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
5848 99 70 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 188 8 2 2 2.2 CCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
CHEMBL4448230 99 70 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 188 8 2 2 2.2 CCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
137658671 158901 0 None 7 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 282 2 2 0 4.5 Fc1cccc2[nH]cc(Cc3c[nH]c4cccc(F)c34)c12 10.1021/acs.jmedchem.6b01593
CHEMBL4101219 158901 0 None 7 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 282 2 2 0 4.5 Fc1cccc2[nH]cc(Cc3c[nH]c4cccc(F)c34)c12 10.1021/acs.jmedchem.6b01593
11213 1413 2 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assay
ChEMBL 299 4 0 2 3.7 [O-][n+]1cccc(c1)CCOc1ccc(c2c1cccc2)Cl 10.1021/acs.jmedchem.0c01378
154578239 1413 2 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assay
ChEMBL 299 4 0 2 3.7 [O-][n+]1cccc(c1)CCOc1ccc(c2c1cccc2)Cl 10.1021/acs.jmedchem.0c01378
CHEMBL4743442 1413 2 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assay
ChEMBL 299 4 0 2 3.7 [O-][n+]1cccc(c1)CCOc1ccc(c2c1cccc2)Cl 10.1021/acs.jmedchem.0c01378
10354234 164 41 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
5846 164 41 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827832 164 41 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
10201214 93144 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 402 2 2 0 5.8 Brc1ccc2[nH]cc(Cc3c[nH]c4ccc(Br)cc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL246504 93144 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 402 2 2 0 5.8 Brc1ccc2[nH]cc(Cc3c[nH]c4ccc(Br)cc34)c2c1 10.1021/acs.jmedchem.6b01593
137643701 157733 0 None -2 2 Human 5.5 pEC50 = 5.5 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4088884 157733 0 None -2 2 Human 5.5 pEC50 = 5.5 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
9944370 93080 4 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 306 4 2 2 4.3 COc1ccc2[nH]cc(Cc3c[nH]c4ccc(OC)cc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL246298 93080 4 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 306 4 2 2 4.3 COc1ccc2[nH]cc(Cc3c[nH]c4ccc(OC)cc34)c2c1 10.1021/acs.jmedchem.6b01593
70233802 140656 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 182 4 2 4 1.6 CCCCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3828115 140656 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 182 4 2 4 1.6 CCCCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
153309768 192228 0 None -5 2 Human 5.4 pEC50 = 5.4 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5179395 192228 0 None -5 2 Human 5.4 pEC50 = 5.4 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221639 192228 0 None -5 2 Human 5.4 pEC50 = 5.4 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
137654126 158467 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 318 2 2 0 4.8 Fc1ccc2[nH]cc(Cc3c[nH]c4ccc(F)c(F)c34)c2c1F 10.1021/acs.jmedchem.6b01593
CHEMBL4096571 158467 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 318 2 2 0 4.8 Fc1ccc2[nH]cc(Cc3c[nH]c4ccc(F)c(F)c34)c2c1F 10.1021/acs.jmedchem.6b01593
5282900 17961 10 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCC(O)CCC(=O)O 10.1039/C7MD00130D
CHEMBL1269402 17961 10 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCC(O)CCC(=O)O 10.1039/C7MD00130D
CHEMBL4283659 17961 10 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCC(O)CCC(=O)O 10.1039/C7MD00130D
127043463 140588 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 248 4 2 5 2.2 Oc1cc(O)nc(SCCc2ccccc2)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827283 140588 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 248 4 2 5 2.2 Oc1cc(O)nc(SCCc2ccccc2)n1 10.1021/acsmedchemlett.6b00025
1563 72570 49 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCCCC(O)C(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL2004471 72570 49 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCCCC(O)C(=O)O 10.1021/acs.jmedchem.9b01339
10717 3161 2 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assay
ChEMBL 211 6 3 3 1.1 CCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
44349321 3161 2 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assay
ChEMBL 211 6 3 3 1.1 CCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL124977 3161 2 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assay
ChEMBL 211 6 3 3 1.1 CCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
137643701 157733 0 None -2 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4088884 157733 0 None -2 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
11209 1522 87 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
3218 1522 87 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL221137 1522 87 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
11208 1395 108 None -2 2 Mouse 5.4 pEC50 = 5.4 Functional
Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.0c01378
3071 1395 108 None -2 2 Mouse 5.4 pEC50 = 5.4 Functional
Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.0c01378
CHEMBL446452 1395 108 None -2 2 Mouse 5.4 pEC50 = 5.4 Functional
Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.0c01378
DB11875 1395 108 None -2 2 Mouse 5.4 pEC50 = 5.4 Functional
Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.0c01378
127045482 140639 0 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 212 3 2 5 1.8 Oc1cc(O)nc(SCC2CCC2)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827914 140639 0 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 212 3 2 5 1.8 Oc1cc(O)nc(SCC2CCC2)n1 10.1021/acsmedchemlett.6b00025
127045103 140592 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 276 6 2 5 3.0 Oc1cc(O)nc(SCCCCc2ccccc2)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827310 140592 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 276 6 2 5 3.0 Oc1cc(O)nc(SCCCCc2ccccc2)n1 10.1021/acsmedchemlett.6b00025
10354234 164 41 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assayAgonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acsmedchemlett.6b00025
5846 164 41 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assayAgonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acsmedchemlett.6b00025
CHEMBL3827832 164 41 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assayAgonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acsmedchemlett.6b00025
135373094 1330 89 None 2 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human N-terminal-FLAG-tagged human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated fro 20 mins followed by forskolin addition measured after 20 minsAgonist activity at human N-terminal-FLAG-tagged human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated fro 20 mins followed by forskolin addition measured after 20 mins
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
2969 1330 89 None 2 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human N-terminal-FLAG-tagged human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated fro 20 mins followed by forskolin addition measured after 20 minsAgonist activity at human N-terminal-FLAG-tagged human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated fro 20 mins followed by forskolin addition measured after 20 mins
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
5532 1330 89 None 2 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human N-terminal-FLAG-tagged human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated fro 20 mins followed by forskolin addition measured after 20 minsAgonist activity at human N-terminal-FLAG-tagged human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated fro 20 mins followed by forskolin addition measured after 20 mins
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
CHEMBL107498 1330 89 None 2 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human N-terminal-FLAG-tagged human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated fro 20 mins followed by forskolin addition measured after 20 minsAgonist activity at human N-terminal-FLAG-tagged human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated fro 20 mins followed by forskolin addition measured after 20 mins
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
DB03600 1330 89 None 2 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human N-terminal-FLAG-tagged human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated fro 20 mins followed by forskolin addition measured after 20 minsAgonist activity at human N-terminal-FLAG-tagged human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated fro 20 mins followed by forskolin addition measured after 20 mins
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
23042624 140644 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 196 5 2 4 2.0 CCCCCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827946 140644 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 196 5 2 4 2.0 CCCCCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
135373094 1330 89 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
2969 1330 89 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5532 1330 89 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL107498 1330 89 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB03600 1330 89 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
135373094 1330 89 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 minsAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 mins
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
2969 1330 89 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 minsAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 mins
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5532 1330 89 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 minsAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 mins
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL107498 1330 89 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 minsAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 mins
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB03600 1330 89 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 minsAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 mins
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
127044607 140605 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 238 8 2 4 3.2 CCCCCCCCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827526 140605 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 238 8 2 4 3.2 CCCCCCCCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
135373094 1330 89 None 2 2 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
2969 1330 89 None 2 2 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5532 1330 89 None 2 2 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL107498 1330 89 None 2 2 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB03600 1330 89 None 2 2 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
135373094 1330 89 None 2 2 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing Galpha16/Gqs5/Gqo5/Gqi9 assessed as increase in calcium mobilization measured for 20 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing Galpha16/Gqs5/Gqo5/Gqi9 assessed as increase in calcium mobilization measured for 20 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
2969 1330 89 None 2 2 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing Galpha16/Gqs5/Gqo5/Gqi9 assessed as increase in calcium mobilization measured for 20 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing Galpha16/Gqs5/Gqo5/Gqi9 assessed as increase in calcium mobilization measured for 20 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5532 1330 89 None 2 2 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing Galpha16/Gqs5/Gqo5/Gqi9 assessed as increase in calcium mobilization measured for 20 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing Galpha16/Gqs5/Gqo5/Gqi9 assessed as increase in calcium mobilization measured for 20 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL107498 1330 89 None 2 2 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing Galpha16/Gqs5/Gqo5/Gqi9 assessed as increase in calcium mobilization measured for 20 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing Galpha16/Gqs5/Gqo5/Gqi9 assessed as increase in calcium mobilization measured for 20 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB03600 1330 89 None 2 2 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing Galpha16/Gqs5/Gqo5/Gqi9 assessed as increase in calcium mobilization measured for 20 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing Galpha16/Gqs5/Gqo5/Gqi9 assessed as increase in calcium mobilization measured for 20 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
10171 1783 16 None - 1 Human 4.3 pEC50 = 4.3 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
71616860 1783 16 None - 1 Human 4.3 pEC50 = 4.3 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
CHEMBL3716365 1783 16 None - 1 Human 4.3 pEC50 = 4.3 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
DB15346 1783 16 None - 1 Human 4.3 pEC50 = 4.3 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
9901435 158453 4 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 314 2 2 0 5.5 Clc1ccc2[nH]cc(Cc3c[nH]c4ccc(Cl)cc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4096406 158453 4 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 314 2 2 0 5.5 Clc1ccc2[nH]cc(Cc3c[nH]c4ccc(Cl)cc34)c2c1 10.1021/acs.jmedchem.6b01593
11208 1395 108 None 2 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
3071 1395 108 None 2 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
CHEMBL446452 1395 108 None 2 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
DB11875 1395 108 None 2 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
10354234 164 41 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human GPR84 by [35S]GTPgammaS binding assayAgonist activity at human GPR84 by [35S]GTPgammaS binding assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.6b01593
5846 164 41 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human GPR84 by [35S]GTPgammaS binding assayAgonist activity at human GPR84 by [35S]GTPgammaS binding assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.6b01593
CHEMBL3827832 164 41 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human GPR84 by [35S]GTPgammaS binding assayAgonist activity at human GPR84 by [35S]GTPgammaS binding assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.6b01593
10354234 164 41 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human GPR84 fused with bovine Galphai1 protein expressed in baculovirus infected sf9 cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human GPR84 fused with bovine Galphai1 protein expressed in baculovirus infected sf9 cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acsmedchemlett.6b00025
5846 164 41 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human GPR84 fused with bovine Galphai1 protein expressed in baculovirus infected sf9 cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human GPR84 fused with bovine Galphai1 protein expressed in baculovirus infected sf9 cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acsmedchemlett.6b00025
CHEMBL3827832 164 41 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human GPR84 fused with bovine Galphai1 protein expressed in baculovirus infected sf9 cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human GPR84 fused with bovine Galphai1 protein expressed in baculovirus infected sf9 cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acsmedchemlett.6b00025
10354234 164 41 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 1 hr by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 1 hr by liquid scintillation counting method
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
5846 164 41 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 1 hr by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 1 hr by liquid scintillation counting method
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827832 164 41 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 1 hr by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 1 hr by liquid scintillation counting method
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
11208 1395 108 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
3071 1395 108 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
CHEMBL446452 1395 108 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
DB11875 1395 108 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
8158 6835 86 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assayAgonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assay
ChEMBL 158 7 1 1 2.8 CCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
CHEMBL108436 6835 86 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assayAgonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assay
ChEMBL 158 7 1 1 2.8 CCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
5850 100 54 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1039/C7MD00130D
94216 100 54 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1039/C7MD00130D
CHEMBL4288936 100 54 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1039/C7MD00130D
137643701 157733 0 None -2 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.0c01378
CHEMBL4088884 157733 0 None -2 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.0c01378
12380289 157647 3 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 260 2 2 1 3.9 O=C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 10.1021/acs.jmedchem.6b01593
CHEMBL4087824 157647 3 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 260 2 2 1 3.9 O=C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 10.1021/acs.jmedchem.6b01593
127045635 140678 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 262 5 2 5 2.6 Oc1cc(O)nc(SCCCc2ccccc2)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3828415 140678 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 262 5 2 5 2.6 Oc1cc(O)nc(SCCCc2ccccc2)n1 10.1021/acsmedchemlett.6b00025
11208 1395 108 None 2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
3071 1395 108 None 2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
CHEMBL446452 1395 108 None 2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
DB11875 1395 108 None 2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
127044299 140668 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 239 8 3 5 2.7 CCCCCCCCNc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3828303 140668 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 239 8 3 5 2.7 CCCCCCCCNc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
10171 1783 16 None - 1 Human 6.2 pEC50 = 6.2 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
71616860 1783 16 None - 1 Human 6.2 pEC50 = 6.2 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
CHEMBL3716365 1783 16 None - 1 Human 6.2 pEC50 = 6.2 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
DB15346 1783 16 None - 1 Human 6.2 pEC50 = 6.2 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
72711216 157223 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 282 2 2 0 4.5 Fc1ccc2c(Cc3c[nH]c4cc(F)ccc34)c[nH]c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4082668 157223 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 282 2 2 0 4.5 Fc1ccc2c(Cc3c[nH]c4cc(F)ccc34)c[nH]c2c1 10.1021/acs.jmedchem.6b01593
11208 1395 108 None 2 2 Human 5.2 pEC50 = 5.2 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
3071 1395 108 None 2 2 Human 5.2 pEC50 = 5.2 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
CHEMBL446452 1395 108 None 2 2 Human 5.2 pEC50 = 5.2 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
DB11875 1395 108 None 2 2 Human 5.2 pEC50 = 5.2 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
11209 1522 87 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
3218 1522 87 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL221137 1522 87 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
11209 1522 87 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
3218 1522 87 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL221137 1522 87 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
127043349 140663 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 228 5 2 5 2.4 CC(C)CCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3828230 140663 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 228 5 2 5 2.4 CC(C)CCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
137643701 157733 0 None -2 2 Human 5.2 pEC50 = 5.2 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.03 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.03 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4088884 157733 0 None -2 2 Human 5.2 pEC50 = 5.2 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.03 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.03 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
10354234 164 41 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acsmedchemlett.6b00025
5846 164 41 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acsmedchemlett.6b00025
CHEMBL3827832 164 41 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acsmedchemlett.6b00025
127045480 140661 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 224 3 2 5 1.8 CCC#CCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3828212 140661 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 224 3 2 5 1.8 CCC#CCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
10171 1783 16 None - 1 Human 6.2 pEC50 = 6.2 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
71616860 1783 16 None - 1 Human 6.2 pEC50 = 6.2 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
CHEMBL3716365 1783 16 None - 1 Human 6.2 pEC50 = 6.2 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
DB15346 1783 16 None - 1 Human 6.2 pEC50 = 6.2 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
11208 1395 108 None 2 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 minsAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 mins
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
3071 1395 108 None 2 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 minsAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 mins
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
CHEMBL446452 1395 108 None 2 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 minsAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 mins
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
DB11875 1395 108 None 2 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 minsAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 mins
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
8158 6835 86 None - 1 Human 4.2 pEC50 = 4.2 Functional
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 158 7 1 1 2.8 CCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
CHEMBL108436 6835 86 None - 1 Human 4.2 pEC50 = 4.2 Functional
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 158 7 1 1 2.8 CCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
135373094 1330 89 None 2 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
2969 1330 89 None 2 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
5532 1330 89 None 2 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
CHEMBL107498 1330 89 None 2 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
DB03600 1330 89 None 2 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
5533 3880 100 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assayAgonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assay
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
8180 3880 100 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assayAgonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assay
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
CHEMBL108030 3880 100 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assayAgonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assay
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
11209 1522 87 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.6b01593
3218 1522 87 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.6b01593
CHEMBL221137 1522 87 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.6b01593
9882204 158941 10 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 282 2 2 0 4.5 Fc1ccc2[nH]cc(Cc3c[nH]c4ccc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4101728 158941 10 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 282 2 2 0 4.5 Fc1ccc2[nH]cc(Cc3c[nH]c4ccc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
127044300 140642 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 224 7 2 4 2.8 CCCCCCCCc1cc(O)nc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827933 140642 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 224 7 2 4 2.8 CCCCCCCCc1cc(O)nc(O)n1 10.1021/acsmedchemlett.6b00025
11208 1395 108 None 2 2 Human 5.1 pEC50 = 5.1 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
3071 1395 108 None 2 2 Human 5.1 pEC50 = 5.1 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
CHEMBL446452 1395 108 None 2 2 Human 5.1 pEC50 = 5.1 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
DB11875 1395 108 None 2 2 Human 5.1 pEC50 = 5.1 Functional
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
153309768 192228 0 None -5 2 Human 4.1 pEC50 = 4.1 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5179395 192228 0 None -5 2 Human 4.1 pEC50 = 4.1 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221639 192228 0 None -5 2 Human 4.1 pEC50 = 4.1 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
5533 3880 100 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
8180 3880 100 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
CHEMBL108030 3880 100 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
3893 2255 92 None -3 4 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 20 mins followed by forskolin-induction and measured after 20 minsAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 20 mins followed by forskolin-induction and measured after 20 mins
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
4642 2255 92 None -3 4 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 20 mins followed by forskolin-induction and measured after 20 minsAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 20 mins followed by forskolin-induction and measured after 20 mins
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
5534 2255 92 None -3 4 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 20 mins followed by forskolin-induction and measured after 20 minsAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 20 mins followed by forskolin-induction and measured after 20 mins
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
CHEMBL108766 2255 92 None -3 4 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 20 mins followed by forskolin-induction and measured after 20 minsAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 20 mins followed by forskolin-induction and measured after 20 mins
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
DB03017 2255 92 None -3 4 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 20 mins followed by forskolin-induction and measured after 20 minsAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 20 mins followed by forskolin-induction and measured after 20 mins
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
127044151 140654 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 244 4 2 4 2.2 CCc1ccc(CCc2nc(O)cc(O)n2)cc1 10.1021/acsmedchemlett.6b00025
CHEMBL3828073 140654 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 244 4 2 4 2.2 CCc1ccc(CCc2nc(O)cc(O)n2)cc1 10.1021/acsmedchemlett.6b00025
3893 2255 92 None -3 4 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assayAgonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
4642 2255 92 None -3 4 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assayAgonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
5534 2255 92 None -3 4 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assayAgonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
CHEMBL108766 2255 92 None -3 4 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assayAgonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
DB03017 2255 92 None -3 4 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assayAgonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
127044950 140567 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 196 3 2 5 1.0 C#CCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3826992 140567 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 196 3 2 5 1.0 C#CCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
3893 2255 92 None -3 4 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
4642 2255 92 None -3 4 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5534 2255 92 None -3 4 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL108766 2255 92 None -3 4 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB03017 2255 92 None -3 4 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
11209 1522 87 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 60 mins by HTRF assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
3218 1522 87 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 60 mins by HTRF assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL221137 1522 87 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 60 mins by HTRF assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
10171 1783 16 None - 1 Human 4.0 pEC50 = 4.0 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
71616860 1783 16 None - 1 Human 4.0 pEC50 = 4.0 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
CHEMBL3716365 1783 16 None - 1 Human 4.0 pEC50 = 4.0 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
DB15346 1783 16 None - 1 Human 4.0 pEC50 = 4.0 Functional
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
127045481 140651 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 226 5 2 5 2.3 CC/C=C\CCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3828033 140651 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 226 5 2 5 2.3 CC/C=C\CCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
12530 5714 84 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 214 11 1 1 4.4 CCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL107874 5714 84 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 214 11 1 1 4.4 CCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
102219032 156819 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 274 2 2 0 4.9 Cc1cccc2[nH]cc(Cc3c[nH]c4cccc(C)c34)c12 10.1021/acs.jmedchem.6b01593
CHEMBL4077871 156819 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 274 2 2 0 4.9 Cc1cccc2[nH]cc(Cc3c[nH]c4cccc(C)c34)c12 10.1021/acs.jmedchem.6b01593
90242131 133137 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 460 6 0 10 2.6 O=c1nc(OC[C@H]2COc3ncccc3O2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
CHEMBL3714891 133137 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 460 6 0 10 2.6 O=c1nc(OC[C@H]2COc3ncccc3O2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
75203411 133144 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 392 4 0 7 2.7 COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
CHEMBL3714917 133144 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 392 4 0 7 2.7 COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
90239661 133145 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 474 6 0 10 3.0 Cc1cc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)on1 nan
CHEMBL3714918 133145 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 474 6 0 10 3.0 Cc1cc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)on1 nan
76684759 133157 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 462 6 0 8 3.2 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCC3COc4ccccc4O3)ccc1-2 nan
CHEMBL3714958 133157 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 462 6 0 8 3.2 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCC3COc4ccccc4O3)ccc1-2 nan
90253121 133180 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 473 5 1 8 2.8 CC(C)CC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3715016 133180 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 473 5 1 8 2.8 CC(C)CC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
76684682 133199 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 477 7 0 9 2.6 CC1(COCc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)COC1 nan
CHEMBL3715069 133199 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 477 7 0 9 2.6 CC1(COCc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)COC1 nan
76684887 133241 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 449 7 0 8 3.5 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccccc3[N+](=O)[O-])ccc1-2 nan
CHEMBL3715210 133241 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 449 7 0 8 3.5 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccccc3[N+](=O)[O-])ccc1-2 nan
90242140 133244 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 418 6 0 6 3.9 Cc1ccccc1COc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
CHEMBL3715227 133244 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 418 6 0 6 3.9 Cc1ccccc1COc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
90240329 133258 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 468 8 0 7 4.1 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCCOc3cccc(Cl)c3)ccc1-2 nan
CHEMBL3715290 133258 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 468 8 0 7 4.1 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCCOc3cccc(Cl)c3)ccc1-2 nan
90240601 133260 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 470 6 0 9 2.4 N#CCCOCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3715307 133260 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 470 6 0 9 2.4 N#CCCOCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
76684890 133287 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 526 6 0 9 3.9 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCC3COc4ccccc4O3)ccc1-2 nan
CHEMBL3715436 133287 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 526 6 0 9 3.9 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCC3COc4ccccc4O3)ccc1-2 nan
90239433 133309 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 464 9 0 8 3.5 COc1cccc(OCCOc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)c1 nan
CHEMBL3715513 133309 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 464 9 0 8 3.5 COc1cccc(OCCOc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)c1 nan
90242113 133347 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 465 4 0 9 3.0 N#Cc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
CHEMBL3715639 133347 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 465 4 0 9 3.0 N#Cc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
90242191 133349 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 517 6 0 11 3.3 CC(C)(C)c1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)no1 nan
CHEMBL3715645 133349 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 517 6 0 11 3.3 CC(C)(C)c1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)no1 nan
76685019 133350 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 418 5 0 9 2.0 N#CCOc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3715646 133350 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 418 5 0 9 2.0 N#CCOc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90241754 133361 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 492 5 1 8 3.5 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 nan
CHEMBL3715684 133361 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 492 5 1 8 3.5 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 nan
90242197 133366 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 445 3 1 8 2.2 CC(C)(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3715691 133366 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 445 3 1 8 2.2 CC(C)(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90242312 133398 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 473 5 1 8 3.0 CCC(O)(C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O)CC nan
CHEMBL3715779 133398 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 473 5 1 8 3.0 CCC(O)(C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O)CC nan
76684894 133436 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 525 8 1 8 3.4 O=C(COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)NCc1ccccc1 nan
CHEMBL3715925 133436 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 525 8 1 8 3.4 O=C(COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)NCc1ccccc1 nan
90241367 133439 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 484 6 0 9 3.5 CCOc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
CHEMBL3715943 133439 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 484 6 0 9 3.5 CCOc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
127024685 133451 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 545 9 1 12 2.1 CCCn1nnnc1NC(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
CHEMBL3715985 133451 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 545 9 1 12 2.1 CCCn1nnnc1NC(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
76685016 133452 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 530 8 0 10 4.0 CCOC(=O)c1ccc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ccccc4O3)nc2=O)o1 nan
CHEMBL3715990 133452 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 530 8 0 10 4.0 CCOC(=O)c1ccc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ccccc4O3)nc2=O)o1 nan
90241697 133489 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 464 9 0 8 3.5 COc1ccccc1OCCOc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
CHEMBL3716125 133489 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 464 9 0 8 3.5 COc1ccccc1OCCOc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
76684889 133507 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 492 6 0 9 3.4 CC(C)(C)OC(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
CHEMBL3716166 133507 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 492 6 0 9 3.4 CC(C)(C)OC(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
90242169 133511 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 443 4 0 9 2.5 Cn1cc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
CHEMBL3716178 133511 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 443 4 0 9 2.5 Cn1cc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
76684664 133515 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 342 4 0 6 2.4 COc1ccc2c(c1)CCn1c-2cc(OCC2CCCCO2)nc1=O nan
CHEMBL3716185 133515 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 342 4 0 6 2.4 COc1ccc2c(c1)CCn1c-2cc(OCC2CCCCO2)nc1=O nan
76685018 133520 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 472 7 0 9 3.7 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3noc(-c4ccccc4)n3)ccc1-2 nan
CHEMBL3716202 133520 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 472 7 0 9 3.7 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3noc(-c4ccccc4)n3)ccc1-2 nan
90239903 133529 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 429 4 0 8 3.3 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3ccoc3)ccc1-2 nan
CHEMBL3716242 133529 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 429 4 0 8 3.3 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3ccoc3)ccc1-2 nan
76685012 133531 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 434 7 0 7 3.6 COc1ccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
CHEMBL3716251 133531 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 434 7 0 7 3.6 COc1ccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
90240535 133555 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 462 7 0 8 3.4 COC(=O)c1cccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)c1 nan
CHEMBL3716311 133555 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 462 7 0 8 3.4 COC(=O)c1cccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)c1 nan
76684492 133572 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 463 6 0 8 2.2 CN(C)C(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
CHEMBL3716369 133572 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 463 6 0 8 2.2 CN(C)C(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
90242224 133580 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 511 7 1 8 3.7 O=C(COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)Nc1ccccc1 nan
CHEMBL3716399 133580 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 511 7 1 8 3.7 O=C(COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)Nc1ccccc1 nan
127024189 133590 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 559 10 1 12 2.5 CCCCn1nnnc1NC(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
CHEMBL3716438 133590 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 559 10 1 12 2.5 CCCCn1nnnc1NC(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
90242703 133592 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 499 6 0 9 3.8 COc1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)c1OC nan
CHEMBL3716443 133592 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 499 6 0 9 3.8 COc1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)c1OC nan
76684665 133601 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 429 6 0 7 3.5 N#Cc1ccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
CHEMBL3716482 133601 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 429 6 0 7 3.5 N#Cc1ccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
90241463 133642 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 499 6 0 9 3.8 COc1ccc(OC)c(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)c1 nan
CHEMBL3716622 133642 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 499 6 0 9 3.8 COc1ccc(OC)c(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)c1 nan
90253113 133673 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 429 6 0 7 3.5 N#Cc1ccccc1COc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
CHEMBL3716734 133673 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 429 6 0 7 3.5 N#Cc1ccccc1COc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
76684577 133680 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 462 6 0 8 3.2 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCC3CCCO3)ccc1-2 nan
CHEMBL3716761 133680 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 462 6 0 8 3.2 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCC3CCCO3)ccc1-2 nan
90253082 133695 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 459 4 2 8 1.1 NC(=O)NCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3716815 133695 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 459 4 2 8 1.1 NC(=O)NCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90242227 133699 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 445 4 1 8 2.2 CCC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3716828 133699 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 445 4 1 8 2.2 CCC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
76684578 133731 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 470 6 0 9 3.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3ccccn3)ccc1-2 nan
CHEMBL3716925 133731 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 470 6 0 9 3.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3ccccn3)ccc1-2 nan
90241694 133732 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 503 7 0 11 3.2 CC(C)c1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)no1 nan
CHEMBL3716930 133732 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 503 7 0 11 3.2 CC(C)c1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)no1 nan
90240538 133761 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 484 6 0 9 3.5 CCOc1ncccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3717010 133761 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 484 6 0 9 3.5 CCOc1ncccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90242083 133779 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 501 7 0 11 2.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3noc(C4CC4)n3)ccc1-2 nan
CHEMBL3717081 133779 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 501 7 0 11 2.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3noc(C4CC4)n3)ccc1-2 nan
90240045 133806 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 440 4 0 8 3.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3ccncc3)ccc1-2 nan
CHEMBL3717169 133806 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 440 4 0 8 3.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3ccncc3)ccc1-2 nan
90242133 133826 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 459 6 1 10 2.7 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(NCc3ncco3)ccc1-2 nan
CHEMBL3717255 133826 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 459 6 1 10 2.7 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(NCc3ncco3)ccc1-2 nan
90241718 133830 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 470 5 0 9 3.2 COc1ncccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3717267 133830 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 470 5 0 9 3.2 COc1ncccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90242208 133841 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 438 6 0 6 4.3 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccc(Cl)cc3)ccc1-2 nan
CHEMBL3717318 133841 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 438 6 0 6 4.3 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccc(Cl)cc3)ccc1-2 nan
90253075 133843 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 506 8 0 10 1.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(COCCN3CCOCC3)ccc1-2 nan
CHEMBL3717323 133843 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 506 8 0 10 1.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(COCCN3CCOCC3)ccc1-2 nan
76684765 133845 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 491 7 0 8 2.9 CC(C)N(C)C(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
CHEMBL3717326 133845 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 491 7 0 8 2.9 CC(C)N(C)C(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
90242015 133857 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 449 7 0 8 3.5 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccc([N+](=O)[O-])cc3)ccc1-2 nan
CHEMBL3717358 133857 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 449 7 0 8 3.5 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccc([N+](=O)[O-])cc3)ccc1-2 nan
90242171 133890 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 500 7 0 11 2.6 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCc3nnnn3C3CC3)ccc1-2 nan
CHEMBL3717472 133890 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 500 7 0 11 2.6 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCc3nnnn3C3CC3)ccc1-2 nan
76685013 133928 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 454 6 0 6 4.8 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccc4ccccc4c3)ccc1-2 nan
CHEMBL3717594 133928 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 454 6 0 6 4.8 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccc4ccccc4c3)ccc1-2 nan
76684489 133948 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 468 8 0 7 4.1 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCCOc3ccc(Cl)cc3)ccc1-2 nan
CHEMBL3717664 133948 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 468 8 0 7 4.1 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCCOc3ccc(Cl)cc3)ccc1-2 nan
76684573 133958 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 463 6 1 8 2.3 CC(C)(Oc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)C(N)=O nan
CHEMBL3717695 133958 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 463 6 1 8 2.3 CC(C)(Oc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)C(N)=O nan
76684667 133965 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 471 7 0 8 4.3 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3cccc(-c4ccoc4)n3)ccc1-2 nan
CHEMBL3717729 133965 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 471 7 0 8 4.3 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3cccc(-c4ccoc4)n3)ccc1-2 nan
90242431 133980 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 363 3 0 7 2.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1ccccc1-2 nan
CHEMBL3717782 133980 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 363 3 0 7 2.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1ccccc1-2 nan
76685010 133982 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 418 6 0 6 3.9 Cc1ccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
CHEMBL3717786 133982 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 418 6 0 6 3.9 Cc1ccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
90242313 133990 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 477 6 0 9 3.0 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCC3CCCCO3)ccc1-2 nan
CHEMBL3717805 133990 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 477 6 0 9 3.0 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCC3CCCCO3)ccc1-2 nan
90240227 134026 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 445 4 0 8 2.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C3=CCOCC3)ccc1-2 nan
CHEMBL3717958 134026 0 None - 1 Human 11.0 pIC50 = 11 Functional
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 445 4 0 8 2.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C3=CCOCC3)ccc1-2 nan