GPCRdb

Variation Browser

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Receptor	Position	GPCRdb	Segment	Variant	Mutation type	Allele Frequency	Allele Count	Allele Number	Homozygotes	SIFT score	PolyPhen score	Functional annotation


Receptor	Position	GPCRdb	Segment	Variant	Mutation Type	Allele Frequency	Allele Count	Allele Number	Homozygotes	SIFT score	PolyPhen score	Functional annotation
cnr2_human	341		C-term	E => GlyfsTer2	frameshift	8.241e-06	1	121346	0	None	None
cnr2_human	257	6.47x47	TM6	C => GlyfsTer20	frameshift	8.24e-06	1	121354	0	None	None
cnr2_human	255	6.45x45	TM6	L => SerfsTer66	frameshift	8.24e-06	1	121356	0	None	None
cnr2_human	236		ICL3	R => Ter	stop gained	0.0001822	22	120734	0	None	None
cnr2_human	194	5.43x43	TM5	W => Ter	stop gained	8.549e-06	1	116970	0	None	None	LB (aromatic (edge-to-face), hydrophobic)
cnr2_human	132	3.51x51	TM3	Y => Ter	stop gained	2.473e-05	3	121288	0	None	None
cnr2_human	131	3.50x50	TM3	R => Ter	stop gained	0.0002144	26	121294	0	None	None	SodiumPocket MicroSwitch GP (contact)
cnr2_human	63	12.49x49	ICL1	Q => Ter	stop gained	8.244e-06	1	121298	0	None	None
cnr2_human	5		N-term	W => Ter	stop gained	1.759e-05	2	113718	0	None	None
cnr2_human	357		C-term	L => F	missense	1.667e-05	2	119990	0	nan	0.0
cnr2_human	354		C-term	D => H	missense	2.489e-05	3	120532	0	nan	0.135
cnr2_human	352		C-term	S => C	missense	8.278e-06	1	120800	0	0.01	0.635	PTM (Phosphorylation)
cnr2_human	348		C-term	P => L	missense	8.252e-05	10	121184	0	0.41	0.0
cnr2_human	342		C-term	A => T	missense	8.241e-06	1	121346	0	0.11	0.004
cnr2_human	339		C-term	E => K	missense	8.238e-06	1	121382	0	0.09	0.04
cnr2_human	338		C-term	T => I	missense	4.118e-05	5	121406	0	0.27	0.031	PTM (Phosphorylation)
cnr2_human	335		C-term	S => F	missense	8.237e-06	1	121406	0	0.02	0.99	PTM (Phosphorylation)
cnr2_human	333		C-term	P => R	missense	8.237e-06	1	121404	0	0.11	0.257
cnr2_human	330		C-term	E => K	missense	4.942e-05	6	121404	0	0.1	0.001
cnr2_human	328		C-term	A => V	missense	2.471e-05	3	121406	0	0.19	0.013
cnr2_human	328		C-term	A => T	missense	1.647e-05	2	121406	0	0.4	0.001
cnr2_human	325		C-term	G => E	missense	8.237e-06	1	121404	0	0.4	0.019
cnr2_human	325		C-term	G => R	missense	8.237e-06	1	121406	0	0.16	0.015
cnr2_human	320		C-term	C => Y	missense	1.647e-05	2	121402	0	1.0	0.0
cnr2_human	320		C-term	C => R	missense	8.237e-06	1	121398	0	0.36	0.0
cnr2_human	316	8.60x60	H8	H => Y	missense	0.09724	11804	121392	700	1.0	0.05
cnr2_human	316	8.60x60	H8	H => N	missense	1.648e-05	2	121392	0	0.34	0.001
cnr2_human	315	8.59x59	H8	A => V	missense	2.471e-05	3	121402	0	0.2	0.004
cnr2_human	313	8.57x57	H8	C => Y	missense	8.237e-06	1	121402	0	1.0	0.032
cnr2_human	308	8.52x52	H8	S => F	missense	8.237e-06	1	121402	0	0.08	0.653
cnr2_human	307	8.51x51	H8	R => H	missense	1.647e-05	2	121404	0	0.05	0.063	GP (contact)
cnr2_human	307	8.51x51	H8	R => C	missense	1.647e-05	2	121404	0	0.02	0.037	GP (contact)
cnr2_human	307	8.51x51	H8	R => G	missense	8.237e-06	1	121404	0	0.01	0.524	GP (contact)
cnr2_human	306	8.50x50	H8	I => V	missense	8.237e-06	1	121402	0	0.06	0.012
cnr2_human	302	7.56x56	TM7	R => W	missense	8.237e-06	1	121402	0	0.02	1.0	GP (contact)
cnr2_human	297	7.51x51	TM7	V => I	missense	8.237e-06	1	121400	0	1.0	0.004
cnr2_human	290	7.44x43	TM7	I => V	missense	8.237e-06	1	121400	0	1.0	0.0	SodiumPocket MicroSwitch
cnr2_human	285	7.39x38	TM7	S => F	missense	8.237e-06	1	121398	0	0.0	0.983	LB (polar (hydrogen bond))
cnr2_human	280	7.34x33	TM7	A => V	missense	0.0006096	74	121382	0	1.0	0.004
cnr2_human	275	7.29x28	TM7	D => E	missense	8.24e-06	1	121366	0	0.22	0.015
cnr2_human	275	7.29x28	TM7	D => A	missense	1.648e-05	2	121366	0	0.07	0.257
cnr2_human	272		ECL3	T => M	missense	9.064e-05	11	121358	0	0.05	0.873
cnr2_human	271	6.61x61	TM6	T => A	missense	8.24e-06	1	121356	0	1.0	0.001
cnr2_human	270	6.60x60	TM6	A => D	missense	8.24e-06	1	121358	0	0.06	0.295
cnr2_human	266	6.56x56	TM6	A => S	missense	1.648e-05	2	121350	0	0.02	0.077
cnr2_human	265	6.55x55	TM6	M => R	missense	1.648e-05	2	121352	0	0.0	0.912	LB (hydrophobic)
cnr2_human	254	6.44x44	TM6	L => F	missense	0.0001648	20	121346	0	0.0	0.969	SodiumPocket MicroSwitch
cnr2_human	250	6.40x40	TM6	V => L	missense	8.246e-06	1	121274	0	0.2	0.09	GP (contact)
cnr2_human	248	6.38x38	TM6	G => V	missense	8.247e-06	1	121250	0	0.3	0.487
cnr2_human	248	6.38x38	TM6	G => R	missense	1.65e-05	2	121246	0	0.07	0.993
cnr2_human	244	6.34x34	TM6	A => D	missense	8.252e-06	1	121176	0	0.0	1.0	SodiumPocket MicroSwitch
cnr2_human	244	6.34x34	TM6	A => V	missense	0.000132	16	121176	0	0.0	1.0	SodiumPocket MicroSwitch
cnr2_human	242	6.32x32	TM6	R => S	missense	8.259e-06	1	121084	0	0.01	0.345	GP (contact)
cnr2_human	242	6.32x32	TM6	R => M	missense	8.26e-06	1	121062	0	0.21	0.078	GP (contact)
cnr2_human	236		ICL3	R => Q	missense	4.141e-05	5	120742	0	0.23	0.908
cnr2_human	236		ICL3	R => G	missense	8.283e-06	1	120734	0	0.02	0.945
cnr2_human	233		ICL3	G => E	missense	8.291e-06	1	120610	0	0.46	0.825
cnr2_human	229		ICL3	R => K	missense	8.304e-06	1	120426	0	0.35	0.01
cnr2_human	228		ICL3	D => N	missense	2.492e-05	3	120370	0	0.51	0.01
cnr2_human	218	5.67x67	TM5	Q => H	missense	8.434e-06	1	118570	0	0.25	0.946	GP (contact)
cnr2_human	218	5.67x67	TM5	Q => R	missense	8.428e-06	1	118654	0	0.4	0.065	GP (contact)
cnr2_human	216	5.65x65	TM5	A => V	missense	5.066e-05	6	118440	0	0.0	1.0	GP (contact)
cnr2_human	211	5.60x60	TM5	H => Q	missense	8.461e-06	1	118196	0	0.11	0.422
cnr2_human	211	5.60x60	TM5	H => L	missense	8.464e-06	1	118142	0	0.31	0.608
cnr2_human	210	5.59x59	TM5	G => R	missense	8.476e-06	1	117986	0	0.14	0.882
cnr2_human	204	5.53x53	TM5	G => R	missense	3.4e-05	4	117650	0	0.37	0.921
cnr2_human	203	5.52x52	TM5	S => C	missense	8.503e-06	1	117608	0	0.2	0.017
cnr2_human	199	5.48x48	TM5	A => G	missense	8.517e-06	1	117408	0	0.23	0.532
cnr2_human	199	5.48x48	TM5	A => T	missense	9.378e-05	11	117298	0	0.44	0.025
cnr2_human	190	5.39x39	TM5	Y => C	missense	8.573e-06	1	116644	0	0.0	0.999	LB (polar (hydrogen bond))
cnr2_human	186		ECL2	I => N	missense	8.608e-06	1	116166	0	0.0	0.939
cnr2_human	178		ECL2	P => T	missense	2.594e-05	3	115670	0	1.0	0.026
cnr2_human	174		ECL2	C => Y	missense	8.648e-06	1	115638	0	0.0	1.0
cnr2_human	164	4.56x56	TM4	V => I	missense	8.547e-06	1	116994	0	1.0	0.023
cnr2_human	159	4.51x51	TM4	V => F	missense	8.459e-06	1	118216	0	0.07	0.089
cnr2_human	158	4.50x50	TM4	W => C	missense	8.449e-06	1	118354	0	0.0	1.0
cnr2_human	155	4.47x47	TM4	G => S	missense	8.264e-06	1	121006	0	0.56	0.08
cnr2_human	154	4.46x46	TM4	L => V	missense	8.262e-06	1	121036	0	0.01	0.982
cnr2_human	148	4.40x40	TM4	G => R	missense	8.252e-06	1	121188	0	0.74	0.023
cnr2_human	147	4.39x39	TM4	R => H	missense	6.602e-05	8	121178	0	0.09	0.04
cnr2_human	144	34.56x56	ICL2	L => Q	missense	8.249e-06	1	121228	0	0.0	0.993	GP (contact)
cnr2_human	142	34.54x54	ICL2	K => R	missense	8.248e-06	1	121242	0	0.12	0.255	GP (contact)
cnr2_human	139	34.51x51	ICL2	P => T	missense	8.247e-06	1	121256	0	0.98	0.018	GP (contact)
cnr2_human	137	3.56x56	TM3	Y => C	missense	8.246e-06	1	121264	0	0.01	0.866	PTM (Phosphorylation) GP (contact)
cnr2_human	136	3.55x55	TM3	R => H	missense	5.773e-05	7	121258	0	1.0	0.002	GP (contact)
cnr2_human	136	3.55x55	TM3	R => C	missense	6.597e-05	8	121272	0	0.24	0.0	GP (contact)
cnr2_human	134	3.53x53	TM3	C => Y	missense	8.246e-06	1	121270	0	0.0	0.995	GP (contact)
cnr2_human	133	3.52x52	TM3	L => I	missense	0.003636	441	121284	3	0.9	0.721
cnr2_human	131	3.50x50	TM3	R => Q	missense	2.474e-05	3	121278	0	0.0	1.0	SodiumPocket MicroSwitch GP (contact)
cnr2_human	128	3.47x47	TM3	A => S	missense	8.245e-06	1	121292	0	0.0	1.0
cnr2_human	119	3.38x38	TM3	A => D	missense	8.242e-06	1	121336	0	0.0	0.991
cnr2_human	117	3.36x36	TM3	F => S	missense	8.241e-06	1	121342	0	0.0	1.0	LB (aromatic (face-to-edge))
cnr2_human	114	3.33x33	TM3	T => P	missense	8.241e-06	1	121346	0	0.01	0.996	PTM (Phosphorylation)
cnr2_human	113	3.32x32	TM3	V => M	missense	8.241e-06	1	121350	0	0.0	1.0	LB (hydrophobic)
cnr2_human	111	3.30x30	TM3	G => S	missense	1.648e-05	2	121348	0	0.02	0.975
cnr2_human	110	3.29x29	TM3	I => M	missense	1.648e-05	2	121350	0	0.01	0.794
cnr2_human	110	3.29x29	TM3	I => T	missense	0.0002555	31	121352	0	0.0	0.751
cnr2_human	101		ECL1	D => A	missense	8.24e-06	1	121352	0	0.0	0.92
cnr2_human	95	2.65x65	TM2	H => R	missense	8.24e-06	1	121354	0	0.0	1.0
cnr2_human	92	2.62x62	TM2	V => M	missense	8.24e-06	1	121354	0	0.0	0.968
cnr2_human	90	2.60x60	TM2	S => N	missense	8.24e-06	1	121356	0	0.2	0.036
cnr2_human	89	2.59x59	TM2	C => Y	missense	1.648e-05	2	121356	0	1.0	0.024
cnr2_human	89	2.59x59	TM2	C => R	missense	8.24e-06	1	121358	0	0.18	0.039
cnr2_human	84	2.54x54	TM2	S => C	missense	4.12e-05	5	121350	0	0.02	0.729
cnr2_human	74	2.44x44	TM2	G => C	missense	8.24e-06	1	121358	0	0.0	0.975
cnr2_human	70	2.40x40	TM2	Y => H	missense	4.944e-05	6	121354	0	0.01	0.995
cnr2_human	66		ICL1	R => Q	missense	0.003504	424	121004	9	0.17	0.319
cnr2_human	66		ICL1	R => W	missense	4.128e-05	5	121114	0	0.01	0.991
cnr2_human	65	12.51x51	ICL1	R => H	missense	1.651e-05	2	121124	0	0.01	0.265
cnr2_human	65	12.51x51	ICL1	R => C	missense	0.0001237	15	121238	0	0.01	0.993
cnr2_human	63	12.49x49	ICL1	Q => R	missense	0.6182	74778	120970	23628	1.0	0.0
cnr2_human	63	12.49x49	ICL1	Q => K	missense	8.244e-06	1	121298	0	0.86	0.0
cnr2_human	62	12.48x48	ICL1	H => R	missense	8.243e-06	1	121310	0	0.8	0.002
cnr2_human	61	1.60x60	TM1	S => F	missense	1.648e-05	2	121324	0	0.0	0.984
cnr2_human	52	1.51x51	TM1	V => M	missense	5.772e-05	7	121270	0	0.19	0.013
cnr2_human	47	1.46x46	TM1	S => R	missense	8.248e-06	1	121242	0	0.03	0.73
cnr2_human	40	1.39x39	TM1	C => Y	missense	3.303e-05	4	121094	0	0.0	0.999
cnr2_human	30	1.29x29	TM1	G => D	missense	9.938e-05	12	120750	0	0.68	0.002
cnr2_human	29	1.28x28	TM1	S => R	missense	8.284e-06	1	120716	0	0.01	0.478	PTM (Phosphorylation)
cnr2_human	22		N-term	M => I	missense	8.331e-06	1	120038	0	0.08	0.004
cnr2_human	22		N-term	M => V	missense	2.501e-05	3	119954	0	0.03	0.049
cnr2_human	22		N-term	M => L	missense	8.337e-06	1	119954	0	0.24	0.004
cnr2_human	20		N-term	N => S	missense	2.507e-05	3	119646	0	0.57	0.007
cnr2_human	18		N-term	D => V	missense	8.414e-06	1	118848	0	0.03	0.059
cnr2_human	16		N-term	G => V	missense	8.457e-06	1	118244	0	0.03	0.157
cnr2_human	15		N-term	D => Y	missense	4.245e-05	5	117788	0	0.04	0.428
cnr2_human	11		N-term	N => S	missense	1.718e-05	2	116444	0	0.05	0.091
cnr2_human	9		N-term	I => M	missense	8.64e-06	1	115736	0	0.18	0.029
cnr2_human	9		N-term	I => T	missense	1.73e-05	2	115616	0	0.67	0.0
cnr2_human	4		N-term	C => Y	missense	8.846e-06	1	113046	0	0.0	0.938

Residue

deleterious missense variants are shown in red
tolerated missense variants are shown in green
loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue

Diagrams

SnakePlot Download: PNG | SVG
HelixBox Download: PNG | SVG

Versions

Package	Name	Version
Django		2.2.1
Python		3.6.7
debug_toolbar	Debug Toolbar	1.11
polymorphic	Polymorphic	2.0.3
rest_framework	Django REST framework	3.9.3
rest_framework_swagger	Rest_Framework_Swagger	2.2.0

Time

Resource usage

Resource	Value
User CPU time	270.643 msec
System CPU time	4.030 msec
Total CPU time	274.673 msec
Elapsed time	284.680 msec
Context switches	9 voluntary, 3 involuntary

Browser timing

Timing attribute	Timeline	Milliseconds since navigation start (+length)

Settings from `protwis.settings`

Setting	Value
ABSOLUTE_URL_OVERRIDES	`{}`
ADMINS	`[]`
ALLOWED_HOSTS	`['*']`
APPEND_SLASH	`True`
AUTHENTICATION_BACKENDS	`['django.contrib.auth.backends.ModelBackend']`
AUTH_PASSWORD_VALIDATORS	`'********************'`
AUTH_USER_MODEL	`'auth.User'`
BASE_DIR	`'/home/protwis/gpcrdb_test'`
BUILD_CACHE_DIR	`'/home/protwis/gpcrdb_data/cache'`
CACHES	`{'alignments': {'BACKEND': 'django.core.cache.backends.filebased.FileBasedCache', 'LOCATION': '/home/protwis/caches/test_alignment', 'OPTIONS': {'MAX_ENTRIES': 1000}}, 'default': {'BACKEND': 'django.core.cache.backends.filebased.FileBasedCache', 'LOCATION': '/home/protwis/caches/test/', 'OPTIONS': {'MAX_ENTRIES': 10000000}}}`
CACHE_MIDDLEWARE_ALIAS	`'default'`
CACHE_MIDDLEWARE_KEY_PREFIX	`'********************'`
CACHE_MIDDLEWARE_SECONDS	`600`
CSRF_COOKIE_AGE	`31449600`
CSRF_COOKIE_DOMAIN	`None`
CSRF_COOKIE_HTTPONLY	`False`
CSRF_COOKIE_NAME	`'csrftoken'`
CSRF_COOKIE_PATH	`'/'`
CSRF_COOKIE_SAMESITE	`'Lax'`
CSRF_COOKIE_SECURE	`False`
CSRF_FAILURE_VIEW	`'django.views.csrf.csrf_failure'`
CSRF_HEADER_NAME	`'HTTP_X_CSRFTOKEN'`
CSRF_TRUSTED_ORIGINS	`[]`
CSRF_USE_SESSIONS	`False`
DATABASES	`{'default': {'ATOMIC_REQUESTS': False, 'AUTOCOMMIT': True, 'CONN_MAX_AGE': 0, 'ENGINE': 'django.db.backends.postgresql_psycopg2', 'HOST': 'localhost', 'NAME': 'protwis_202107', 'OPTIONS': {}, 'PASSWORD': '********************', 'PORT': '', 'TEST': {'CHARSET': None, 'COLLATION': None, 'MIRROR': None, 'NAME': None}, 'TIME_ZONE': None, 'USER': 'protwis'}}`
DATABASE_ROUTERS	`[]`
DATA_DIR	`'/home/protwis/gpcrdb_data'`
DATA_UPLOAD_MAX_MEMORY_SIZE	`2621440`
DATA_UPLOAD_MAX_NUMBER_FIELDS	`1000`
DATETIME_FORMAT	`'N j, Y, P'`
DATETIME_INPUT_FORMATS	`['%Y-%m-%d %H:%M:%S', '%Y-%m-%d %H:%M:%S.%f', '%Y-%m-%d %H:%M', '%Y-%m-%d', '%m/%d/%Y %H:%M:%S', '%m/%d/%Y %H:%M:%S.%f', '%m/%d/%Y %H:%M', '%m/%d/%Y', '%m/%d/%y %H:%M:%S', '%m/%d/%y %H:%M:%S.%f', '%m/%d/%y %H:%M', '%m/%d/%y']`
DATE_FORMAT	`'N j, Y'`
DATE_INPUT_FORMATS	`['%Y-%m-%d', '%m/%d/%Y', '%m/%d/%y', '%b %d %Y', '%b %d, %Y', '%d %b %Y', '%d %b, %Y', '%B %d %Y', '%B %d, %Y', '%d %B %Y', '%d %B, %Y']`
DEBUG	`True`
DEBUG_PROPAGATE_EXCEPTIONS	`False`
DEBUG_TOOLBAR_PATCH_SETTINGS	`False`
DECIMAL_SEPARATOR	`'.'`
DEFAULT_CHARSET	`'utf-8'`
DEFAULT_CONTENT_TYPE	`'text/html'`
DEFAULT_EXCEPTION_REPORTER_FILTER	`'django.views.debug.SafeExceptionReporterFilter'`
DEFAULT_FILE_STORAGE	`'django.core.files.storage.FileSystemStorage'`
DEFAULT_FROM_EMAIL	`'webmaster@localhost'`
DEFAULT_INDEX_TABLESPACE	`''`
DEFAULT_NUMBERING_SCHEME	`'gpcrdb'`
DEFAULT_PROTEIN_STATE	`'inactive'`
DEFAULT_SITE	`'gpcr'`
DEFAULT_TABLESPACE	`''`
DISALLOWED_USER_AGENTS	`[]`
DOCUMENTATION_URL	`'https://docs.gpcrdb.org/'`
EMAIL_BACKEND	`'django.core.mail.backends.smtp.EmailBackend'`
EMAIL_HOST	`'localhost'`
EMAIL_HOST_PASSWORD	`'********************'`
EMAIL_HOST_USER	`''`
EMAIL_PORT	`25`
EMAIL_SSL_CERTFILE	`None`
EMAIL_SSL_KEYFILE	`'********************'`
EMAIL_SUBJECT_PREFIX	`'[Django] '`
EMAIL_TIMEOUT	`None`
EMAIL_USE_LOCALTIME	`False`
EMAIL_USE_SSL	`False`
EMAIL_USE_TLS	`False`
FILE_CHARSET	`'utf-8'`
FILE_UPLOAD_DIRECTORY_PERMISSIONS	`None`
FILE_UPLOAD_HANDLERS	`['django.core.files.uploadhandler.MemoryFileUploadHandler', 'django.core.files.uploadhandler.TemporaryFileUploadHandler']`
FILE_UPLOAD_MAX_MEMORY_SIZE	`2621440`
FILE_UPLOAD_PERMISSIONS	`None`
FILE_UPLOAD_TEMP_DIR	`None`
FIRST_DAY_OF_WEEK	`0`
FIXTURE_DIRS	`[]`
FORCE_SCRIPT_NAME	`None`
FORMAT_MODULE_PATH	`None`
FORM_RENDERER	`'django.forms.renderers.DjangoTemplates'`
GOOGLE_ANALYTICS_API	`'********************'`
GOOGLE_ANALYTICS_KEY	`'********************'`
IGNORABLE_404_URLS	`[]`
INSTALLED_APPS	('django.contrib.admin', 'django.contrib.auth', 'django.contrib.contenttypes', 'django.contrib.sessions', 'django.contrib.messages', 'django.contrib.staticfiles', 'django.contrib.humanize', 'debug_toolbar', 'rest_framework', 'rest_framework_swagger', 'polymorphic', 'common', 'api', 'news', 'pages', 'home', 'protein', 'family', 'residue', 'alignment', 'similaritysearch', 'similaritymatrix', 'structure', 'ligand', 'interaction', 'mutation', 'phylogenetic_trees', 'sitesearch', 'build_gpcr', 'construct', 'tools', 'drugs', 'signprot', 'signprot2', 'mutational_landscape', 'contactnetwork', 'seqsign', 'angles', 'hotspots')
INTERNAL_IPS	`'10.0.2.2'`
LANGUAGES	[('af', 'Afrikaans'), ('ar', 'Arabic'), ('ast', 'Asturian'), ('az', 'Azerbaijani'), ('bg', 'Bulgarian'), ('be', 'Belarusian'), ('bn', 'Bengali'), ('br', 'Breton'), ('bs', 'Bosnian'), ('ca', 'Catalan'), ('cs', 'Czech'), ('cy', 'Welsh'), ('da', 'Danish'), ('de', 'German'), ('dsb', 'Lower Sorbian'), ('el', 'Greek'), ('en', 'English'), ('en-au', 'Australian English'), ('en-gb', 'British English'), ('eo', 'Esperanto'), ('es', 'Spanish'), ('es-ar', 'Argentinian Spanish'), ('es-co', 'Colombian Spanish'), ('es-mx', 'Mexican Spanish'), ('es-ni', 'Nicaraguan Spanish'), ('es-ve', 'Venezuelan Spanish'), ('et', 'Estonian'), ('eu', 'Basque'), ('fa', 'Persian'), ('fi', 'Finnish'), ('fr', 'French'), ('fy', 'Frisian'), ('ga', 'Irish'), ('gd', 'Scottish Gaelic'), ('gl', 'Galician'), ('he', 'Hebrew'), ('hi', 'Hindi'), ('hr', 'Croatian'), ('hsb', 'Upper Sorbian'), ('hu', 'Hungarian'), ('hy', 'Armenian'), ('ia', 'Interlingua'), ('id', 'Indonesian'), ('io', 'Ido'), ('is', 'Icelandic'), ('it', 'Italian'), ('ja', 'Japanese'), ('ka', 'Georgian'), ('kab', 'Kabyle'), ('kk', 'Kazakh'), ('km', 'Khmer'), ('kn', 'Kannada'), ('ko', 'Korean'), ('lb', 'Luxembourgish'), ('lt', 'Lithuanian'), ('lv', 'Latvian'), ('mk', 'Macedonian'), ('ml', 'Malayalam'), ('mn', 'Mongolian'), ('mr', 'Marathi'), ('my', 'Burmese'), ('nb', 'Norwegian Bokmål'), ('ne', 'Nepali'), ('nl', 'Dutch'), ('nn', 'Norwegian Nynorsk'), ('os', 'Ossetic'), ('pa', 'Punjabi'), ('pl', 'Polish'), ('pt', 'Portuguese'), ('pt-br', 'Brazilian Portuguese'), ('ro', 'Romanian'), ('ru', 'Russian'), ('sk', 'Slovak'), ('sl', 'Slovenian'), ('sq', 'Albanian'), ('sr', 'Serbian'), ('sr-latn', 'Serbian Latin'), ('sv', 'Swedish'), ('sw', 'Swahili'), ('ta', 'Tamil'), ('te', 'Telugu'), ('th', 'Thai'), ('tr', 'Turkish'), ('tt', 'Tatar'), ('udm', 'Udmurt'), ('uk', 'Ukrainian'), ('ur', 'Urdu'), ('vi', 'Vietnamese'), ('zh-hans', 'Simplified Chinese'), ('zh-hant', 'Traditional Chinese')]
LANGUAGES_BIDI	`['he', 'ar', 'fa', 'ur']`
LANGUAGE_CODE	`'en-us'`
LANGUAGE_COOKIE_AGE	`None`
LANGUAGE_COOKIE_DOMAIN	`None`
LANGUAGE_COOKIE_NAME	`'django_language'`
LANGUAGE_COOKIE_PATH	`'/'`
LOCALE_PATHS	`[]`
LOGGING	{'disable_existing_loggers': False, 'formatters': {'verbose': {'datefmt': '%d/%b/%Y %H:%M:%S', 'format': '[%(asctime)s] %(levelname)s ' '[%(name)s:%(lineno)s] %(message)s'}, 'verbose_low': {'datefmt': '%d/%b/%Y %H:%M:%S', 'format': '[%(asctime)s] %(levelname)s ' '[%(name)s:%(lineno)s]'}}, 'handlers': {'build': {'class': 'logging.FileHandler', 'filename': 'logs/build.log', 'formatter': 'verbose', 'level': 'DEBUG'}, 'django': {'class': 'logging.FileHandler', 'filename': 'logs/django.log', 'formatter': 'verbose', 'level': 'WARNING'}, 'protwis': {'class': 'logging.FileHandler', 'filename': 'logs/protwis.log', 'formatter': 'verbose', 'level': 'DEBUG'}}, 'loggers': {'build': {'handlers': ['build'], 'level': 'DEBUG'}, 'django': {'handlers': ['django'], 'level': 'WARNING', 'propagate': True}, 'protwis': {'handlers': ['protwis'], 'level': 'DEBUG'}}, 'version': 1}
LOGGING_CONFIG	`'logging.config.dictConfig'`
LOGIN_REDIRECT_URL	`'/accounts/profile/'`
LOGIN_URL	`'/accounts/login/'`
LOGOUT_REDIRECT_URL	`None`
MANAGERS	`[]`
MEDIA_ROOT	`'/protwis/media/protwis'`
MEDIA_URL	`'/media/'`
MESSAGE_STORAGE	`'django.contrib.messages.storage.fallback.FallbackStorage'`
MIDDLEWARE	`('common.middleware.stats.StatsMiddleware', 'debug_toolbar.middleware.DebugToolbarMiddleware', 'django.contrib.sessions.middleware.SessionMiddleware', 'django.middleware.common.CommonMiddleware', 'django.middleware.csrf.CsrfViewMiddleware', 'django.contrib.auth.middleware.AuthenticationMiddleware', 'django.contrib.messages.middleware.MessageMiddleware', 'django.middleware.clickjacking.XFrameOptionsMiddleware')`
MIGRATION_MODULES	`{}`
MONTH_DAY_FORMAT	`'F j'`
NUMBER_GROUPING	`0`
PASSWORD_HASHERS	`'********************'`
PASSWORD_RESET_TIMEOUT_DAYS	`'********************'`
PREPEND_WWW	`False`
REFERENCE_POSITIONS	`{'D1S1': 'D1S1x50', 'D1S2': 'D1S2x50', 'D1T1': 'D1T1x50', 'D1e1': 'D1e1x50', 'ECL1': '23x50', 'ECL2': '45x50', 'H8': '8x50', 'ICL1': '12x50', 'ICL2': '34x50', 'TM1': '1x50', 'TM2': '2x50', 'TM3': '3x50', 'TM4': '4x50', 'TM5': '5x50', 'TM6': '6x50', 'TM7': '7x50'}`
ROOT_URLCONF	`'protwis.urls'`
SECRET_KEY	`'********************'`
SECURE_BROWSER_XSS_FILTER	`False`
SECURE_CONTENT_TYPE_NOSNIFF	`False`
SECURE_HSTS_INCLUDE_SUBDOMAINS	`False`
SECURE_HSTS_PRELOAD	`False`
SECURE_HSTS_SECONDS	`0`
SECURE_PROXY_SSL_HEADER	`None`
SECURE_REDIRECT_EXEMPT	`[]`
SECURE_SSL_HOST	`None`
SECURE_SSL_REDIRECT	`False`
SERVER_EMAIL	`'root@localhost'`
SESSION_CACHE_ALIAS	`'default'`
SESSION_COOKIE_AGE	`86400`
SESSION_COOKIE_DOMAIN	`None`
SESSION_COOKIE_HTTPONLY	`True`
SESSION_COOKIE_NAME	`'sessionid'`
SESSION_COOKIE_PATH	`'/'`
SESSION_COOKIE_SAMESITE	`'Lax'`
SESSION_COOKIE_SECURE	`False`
SESSION_ENGINE	`'django.contrib.sessions.backends.db'`
SESSION_EXPIRE_AT_BROWSER_CLOSE	`False`
SESSION_FILE_PATH	`None`
SESSION_SAVE_EVERY_REQUEST	`False`
SESSION_SERIALIZER	`'django.contrib.sessions.serializers.PickleSerializer'`
SETTINGS_MODULE	`'protwis.settings'`
SHORT_DATETIME_FORMAT	`'m/d/Y P'`
SHORT_DATE_FORMAT	`'m/d/Y'`
SIGNING_BACKEND	`'django.core.signing.TimestampSigner'`
SILENCED_SYSTEM_CHECKS	`[]`
SITE_NAME	`'gpcr'`
SITE_TITLE	`'GPCRdb'`
STATICFILES_DIRS	`('/home/protwis/gpcrdb_test/static',)`
STATICFILES_FINDERS	`['django.contrib.staticfiles.finders.FileSystemFinder', 'django.contrib.staticfiles.finders.AppDirectoriesFinder']`
STATICFILES_STORAGE	`'django.contrib.staticfiles.storage.StaticFilesStorage'`
STATIC_ROOT	`'/home/protwis/static_test/'`
STATIC_URL	`'/static/'`
SWAGGER_SETTINGS	`{'USE_SESSION_AUTH': False}`
TEMPLATES	[{'APP_DIRS': True, 'BACKEND': 'django.template.backends.django.DjangoTemplates', 'DIRS': [], 'OPTIONS': {'context_processors': ['django.contrib.auth.context_processors.auth', 'django.template.context_processors.debug', 'django.template.context_processors.i18n', 'django.template.context_processors.media', 'django.template.context_processors.static', 'django.template.context_processors.tz', 'django.contrib.messages.context_processors.messages', 'protwis.context_processors.current_site', 'protwis.context_processors.canonical_tag', 'protwis.context_processors.documentation_url', 'protwis.context_processors.google_analytics', 'protwis.context_processors.site_title'], 'debug': True}}]
TEST_NON_SERIALIZED_APPS	`[]`
TEST_RUNNER	`'django.test.runner.DiscoverRunner'`
THOUSAND_SEPARATOR	`','`
TIME_FORMAT	`'P'`
TIME_INPUT_FORMATS	`['%H:%M:%S', '%H:%M:%S.%f', '%H:%M']`
TIME_ZONE	`'Europe/Copenhagen'`
USE_I18N	`True`
USE_L10N	`True`
USE_THOUSAND_SEPARATOR	`False`
USE_TZ	`True`
USE_X_FORWARDED_HOST	`False`
USE_X_FORWARDED_PORT	`False`
WSGI_APPLICATION	`None`
X_FRAME_OPTIONS	`'SAMEORIGIN'`
YEAR_MONTH_FORMAT	`'F Y'`

Headers

Request headers

Key	Value
Accept	text/html,application/xhtml+xml,application/xml;q=0.9,/;q=0.8
Accept-Encoding	br,gzip
Accept-Language	en-US,en;q=0.5
Connection	close
Host	test.gpcrdb.org
User-Agent	CCBot/2.0 (https://commoncrawl.org/faq/)
X-Forwarded-For	3.236.207.90
X-Forwarded-Proto	https
X-Real-Ip	3.236.207.90

Response headers

Key	Value
Content-Length	495846
Content-Type	text/html; charset=utf-8
Vary	Cookie
X-Frame-Options	SAMEORIGIN

WSGI environ

Since the WSGI environ inherits the environment of the server, only a significant subset is shown below.

Key	Value
PATH_INFO	/mutational_landscape/protein/CNR2_human/
QUERY_STRING
REMOTE_ADDR
REQUEST_METHOD	GET
SCRIPT_NAME
SERVER_NAME	test.gpcrdb.org
SERVER_PORT	443
SERVER_PROTOCOL	HTTP/1.0
SERVER_SOFTWARE	gunicorn/19.9.0

Request

View information

View function	Arguments	Keyword arguments	URL name
`mutational_landscape.views.render_variants`	`()`	`{'protein': 'CNR2_human'}`	`render`

No cookies

No session data

No GET data

No POST data

SQL queries from 1 connection

default 2.71 ms (1 query )

	Query	Timeline	Time (ms)	Action
	+	SELECT ••• "protein"."id", "protein"."parent_id", "protein"."family_id", "protein"."species_id", "protein"."source_id", "protein"."residue_numbering_scheme_id", "protein"."sequence_type_id", "protein"."entry_name", "protein"."accession", "protein"."name", "protein"."sequence" FROM "protein" WHERE "protein"."entry_name" = 'cnr2_human'	100.0%	2.71
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(89) proteins.append(Protein.objects.get(entry_name=protein.lower()))

Query

Timeline

Time (ms)

Action

SELECT ••• "protein"."id", "protein"."parent_id", "protein"."family_id", "protein"."species_id", "protein"."source_id", "protein"."residue_numbering_scheme_id", "protein"."sequence_type_id", "protein"."entry_name", "protein"."accession", "protein"."name", "protein"."sequence" FROM "protein" WHERE "protein"."entry_name" = 'cnr2_human'

100.0%

2.71

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(89)
  proteins.append(Protein.objects.get(entry_name=protein.lower()))

Static files (590 found, 40 used)

Static file path

/home/protwis/gpcrdb_test/static

Static file apps

django.contrib.admin
debug_toolbar
rest_framework
rest_framework_swagger
polymorphic

Static files

bootstrap/css/bootstrap.min.css: /home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap.min.css
bootstrap/css/bootstrap-submenu.min.css: /home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap-submenu.min.css
home/css/jquery-ui.min.css: /home/protwis/gpcrdb_test/static/home/css/jquery-ui.min.css
home/css/jquery-ui.theme.min.css: /home/protwis/gpcrdb_test/static/home/css/jquery-ui.theme.min.css
home/css/bootstrap-treeview.min.css: /home/protwis/gpcrdb_test/static/home/css/bootstrap-treeview.min.css
home/css/style.css: /home/protwis/gpcrdb_test/static/home/css/style.css
flowplayer/flowplayer.css: /home/protwis/gpcrdb_test/static/flowplayer/flowplayer.css
home/css/cookieconsent.min.css: /home/protwis/gpcrdb_test/static/home/css/cookieconsent.min.css
home/css/jquery.dataTables.min.css: /home/protwis/gpcrdb_test/static/home/css/jquery.dataTables.min.css
home/css/structure_browser.css: /home/protwis/gpcrdb_test/static/home/css/structure_browser.css
home/css/residue_table.css: /home/protwis/gpcrdb_test/static/home/css/residue_table.css
home/css/alignment.css: /home/protwis/gpcrdb_test/static/home/css/alignment.css
: /home/protwis/gpcrdb_test/static
home/css/mainmenu.css: /home/protwis/gpcrdb_test/static/home/css/mainmenu.css
home/css/modal.css: /home/protwis/gpcrdb_test/static/home/css/modal.css
home/css/jquery.powertip.css: /home/protwis/gpcrdb_test/static/home/css/jquery.powertip.css
home/js/jquery-3.1.1.min.js: /home/protwis/gpcrdb_test/static/home/js/jquery-3.1.1.min.js
home/js/citation_tool.js: /home/protwis/gpcrdb_test/static/home/js/citation_tool.js
home/js/joinus_tool.js: /home/protwis/gpcrdb_test/static/home/js/joinus_tool.js
home/js/jquery-3.1.1.min.js: /home/protwis/gpcrdb_test/static/home/js/jquery-3.1.1.min.js
home/js/jquery-ui.min.js: /home/protwis/gpcrdb_test/static/home/js/jquery-ui.min.js
bootstrap/js/bootstrap.min.js: /home/protwis/gpcrdb_test/static/bootstrap/js/bootstrap.min.js
bootstrap/js/bootstrap-submenu.js: /home/protwis/gpcrdb_test/static/bootstrap/js/bootstrap-submenu.js
home/js/navbar-autocomplete.js: /home/protwis/gpcrdb_test/static/home/js/navbar-autocomplete.js
home/js/svg-pan-zoom.min.js: /home/protwis/gpcrdb_test/static/home/js/svg-pan-zoom.min.js
home/js/bootstrap-treeview.min.js: /home/protwis/gpcrdb_test/static/home/js/bootstrap-treeview.min.js
home/js/papaparse.min.js: /home/protwis/gpcrdb_test/static/home/js/papaparse.min.js
flowplayer/flowplayer.min.js: /home/protwis/gpcrdb_test/static/flowplayer/flowplayer.min.js
flowplayer/flowplayer.overlay.min.js: /home/protwis/gpcrdb_test/static/flowplayer/flowplayer.overlay.min.js
flowplayer/flowplayer.overlay.bootstrap.js: /home/protwis/gpcrdb_test/static/flowplayer/flowplayer.overlay.bootstrap.js
home/js/gpcrdb.js: /home/protwis/gpcrdb_test/static/home/js/gpcrdb.js
home/js/cookieconsent.min.js: /home/protwis/gpcrdb_test/static/home/js/cookieconsent.min.js
home/js/jquery.dataTables.min.js: /home/protwis/gpcrdb_test/static/home/js/jquery.dataTables.min.js
home/js/dataTables.tableTools.min.js: /home/protwis/gpcrdb_test/static/home/js/dataTables.tableTools.min.js
home/js/jquery.dataTables.columnFilter.js: /home/protwis/gpcrdb_test/static/home/js/jquery.dataTables.columnFilter.js
home/js/selection.js: /home/protwis/gpcrdb_test/static/home/js/selection.js
home/js/saveSvgAsPng.js: /home/protwis/gpcrdb_test/static/home/js/saveSvgAsPng.js
home/js/alignment.js: /home/protwis/gpcrdb_test/static/home/js/alignment.js
home/js/diagrams.js: /home/protwis/gpcrdb_test/static/home/js/diagrams.js
home/js/residuetable.js: /home/protwis/gpcrdb_test/static/home/js/residuetable.js

django.contrib.staticfiles.finders.FileSystemFinder (415 files)

Path	Location
visualization_scripts/maestro_label_generic_numbers.py	/home/protwis/gpcrdb_test/static/visualization_scripts/maestro_label_generic_numbers.py
visualization_scripts/pymol_view_generic_numbers.pml	/home/protwis/gpcrdb_test/static/visualization_scripts/pymol_view_generic_numbers.pml
bootstrap/js/npm.js	/home/protwis/gpcrdb_test/static/bootstrap/js/npm.js
bootstrap/js/bootstrap.js	/home/protwis/gpcrdb_test/static/bootstrap/js/bootstrap.js
bootstrap/js/bootstrap-submenu.js	/home/protwis/gpcrdb_test/static/bootstrap/js/bootstrap-submenu.js
bootstrap/js/bootstrap.min.js	/home/protwis/gpcrdb_test/static/bootstrap/js/bootstrap.min.js
bootstrap/fonts/glyphicons-halflings-regular.eot	/home/protwis/gpcrdb_test/static/bootstrap/fonts/glyphicons-halflings-regular.eot
bootstrap/fonts/glyphicons-halflings-regular.woff	/home/protwis/gpcrdb_test/static/bootstrap/fonts/glyphicons-halflings-regular.woff
bootstrap/fonts/glyphicons-halflings-regular.ttf	/home/protwis/gpcrdb_test/static/bootstrap/fonts/glyphicons-halflings-regular.ttf
bootstrap/fonts/glyphicons-halflings-regular.svg	/home/protwis/gpcrdb_test/static/bootstrap/fonts/glyphicons-halflings-regular.svg
bootstrap/fonts/glyphicons-halflings-regular.woff2	/home/protwis/gpcrdb_test/static/bootstrap/fonts/glyphicons-halflings-regular.woff2
bootstrap/css/bootstrap.css.map	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap.css.map
bootstrap/css/bootstrap-submenu.css	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap-submenu.css
bootstrap/css/bootstrap.css	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap.css
bootstrap/css/bootstrap-theme.css.map	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap-theme.css.map
bootstrap/css/bootstrap-theme.min.css.map	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap-theme.min.css.map
bootstrap/css/bootstrap-submenu.min.css	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap-submenu.min.css
bootstrap/css/bootstrap.min.css.map	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap.min.css.map
bootstrap/css/bootstrap-submenu.css.map	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap-submenu.css.map
bootstrap/css/bootstrap.min.css	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap.min.css
bootstrap/css/bootstrap-theme.css	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap-theme.css
bootstrap/css/bootstrap-theme.min.css	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap-theme.min.css
blast/protwis_blastdb.psq	/home/protwis/gpcrdb_test/static/blast/protwis_blastdb.psq
blast/protwis_human_bundle_blastdb.pin	/home/protwis/gpcrdb_test/static/blast/protwis_human_bundle_blastdb.pin
blast/protwis_blastdb.pin	/home/protwis/gpcrdb_test/static/blast/protwis_blastdb.pin
blast/protwis_human_blastdb.phr	/home/protwis/gpcrdb_test/static/blast/protwis_human_blastdb.phr
blast/protwis_blastdb.psd	/home/protwis/gpcrdb_test/static/blast/protwis_blastdb.psd
blast/protwis_blastdb.phr	/home/protwis/gpcrdb_test/static/blast/protwis_blastdb.phr
blast/protwis_human_blastdb.psq	/home/protwis/gpcrdb_test/static/blast/protwis_human_blastdb.psq
blast/protwis_human_gpcr_blastdb.phr	/home/protwis/gpcrdb_test/static/blast/protwis_human_gpcr_blastdb.phr
blast/protwis_human_gpcr_blastdb.psq	/home/protwis/gpcrdb_test/static/blast/protwis_human_gpcr_blastdb.psq
blast/protwis_gpcr_blastdb.psd	/home/protwis/gpcrdb_test/static/blast/protwis_gpcr_blastdb.psd
blast/protwis_human_blastdb.pin	/home/protwis/gpcrdb_test/static/blast/protwis_human_blastdb.pin
blast/protwis_human_blastdb.psd	/home/protwis/gpcrdb_test/static/blast/protwis_human_blastdb.psd
blast/protwis_human_blastdb.pog	/home/protwis/gpcrdb_test/static/blast/protwis_human_blastdb.pog
blast/.gitignore	/home/protwis/gpcrdb_test/static/blast/.gitignore
blast/protwis_human_gpcr_blastdb.psd	/home/protwis/gpcrdb_test/static/blast/protwis_human_gpcr_blastdb.psd
blast/protwis_blastdb.pog	/home/protwis/gpcrdb_test/static/blast/protwis_blastdb.pog
blast/protwis_gpcr_blastdb.psq	/home/protwis/gpcrdb_test/static/blast/protwis_gpcr_blastdb.psq
blast/protwis_human_gpcr_blastdb.psi	/home/protwis/gpcrdb_test/static/blast/protwis_human_gpcr_blastdb.psi
blast/protwis_gpcr_blastdb.pin	/home/protwis/gpcrdb_test/static/blast/protwis_gpcr_blastdb.pin
blast/protwis_human_bundle_blastdb.pog	/home/protwis/gpcrdb_test/static/blast/protwis_human_bundle_blastdb.pog
blast/protwis_human_gpcr_blastdb.pog	/home/protwis/gpcrdb_test/static/blast/protwis_human_gpcr_blastdb.pog
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django.contrib.staticfiles.finders.AppDirectoriesFinder (175 files)

Templates (9 rendered)

Template paths

None

Templates

browser.html: /home/protwis/gpcrdb_test/mutational_landscape/templates/browser.html; Toggle context
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"#575c9d", ""], "357": ["F", 1.667e-05, ' '2, 119990, 0, "missense", "tolerated", "#70c070", ""], ' '"354": ["H", 2.489e-05, 3, 120532, 0, "missense", ' '"deleterious", "#e30e0e", ""], "352": ["C", 8.278e-06, ' '1, 120800, 0, "missense", "deleterious", "#e30e0e", ' '"PTM (Phosphorylation) "], "348": ["L", 8.252e-05, 10, ' '121184, 0, "missense", "tolerated", "#70c070", ""], ' '"342": ["T", 8.241e-06, 1, 121346, 0, "missense", ' '"tolerated", "#70c070", ""], "339": ["K", 8.238e-06, ' '1, 121382, 0, "missense", "tolerated", "#70c070", ""], ' '"338": ["I", 4.118e-05, 5, 121406, 0, "missense", ' '"tolerated", "#70c070", "PTM (Phosphorylation) "], ' '"335": ["F", 8.237e-06, 1, 121406, 0, "missense", ' '"deleterious", "#e30e0e", "PTM (Phosphorylation) "], ' '"333": ["R", 8.237e-06, 1, 121404, 0, "missense", ' '"deleterious", "#e30e0e", ""], "330": ["K", 4.942e-05, ' '6, 121404, 0, "missense", "tolerated", "#70c070", ""], ' '"328": ["T", 1.647e-05, 2, 121406, 0, "missense", ' '"tolerated", "#70c070", ""], "325": ["R", 8.237e-06, ' '1, 121406, 0, "missense", "tolerated", "#70c070", ""], ' '"320": ["R", 8.237e-06, 1, 121398, 0, "missense", ' '"tolerated", "#70c070", ""], "316": ["N", 1.648e-05, ' '2, 121392, 0, "missense", "tolerated", "#70c070", ""], ' '"315": ["V", 2.471e-05, 3, 121402, 0, "missense", ' '"tolerated", "#70c070", ""], "313": ["Y", 8.237e-06, ' '1, 121402, 0, "missense", "tolerated", "#70c070", ""], ' '"308": ["F", 8.237e-06, 1, 121402, 0, "missense", ' '"deleterious", "#e30e0e", ""], "307": ["G", 8.237e-06, ' '1, 121404, 0, "missense", "deleterious", "#e30e0e", ' '"GP (contact) "], "306": ["V", 8.237e-06, 1, 121402, ' '0, "missense", "tolerated", "#70c070", ""], "302": ' '["W", 8.237e-06, 1, 121402, 0, "missense", ' '"deleterious", "#e30e0e", "GP (contact) "], "297": ' '["I", 8.237e-06, 1, 121400, 0, "missense", ' '"tolerated", "#70c070", ""], "290": ["V", 8.237e-06, ' '1, 121400, 0, "missense", "tolerated", "#70c070", ' '"SodiumPocket MicroSwitch "], "285": ["F", 8.237e-06, ' '1, 121398, 0, "missense", "deleterious", "#e30e0e", ' '"LB (polar (hydrogen bond)) "], "280": ["V", ' '0.0006096, 74, 121382, 0, "missense", "tolerated", ' '"#70c070", ""], "275": ["A", 1.648e-05, 2, 121366, 0, ' '"missense", "deleterious", "#e30e0e", ""], "272": ' '["M", 9.064e-05, 11, 121358, 0, "missense", ' '"deleterious", "#e30e0e", ""], "271": ["A", 8.24e-06, ' '1, 121356, 0, "missense", "tolerated", "#70c070", ""], ' '"270": ["D", 8.24e-06, 1, 121358, 0, "missense", ' '"deleterious", "#e30e0e", ""], "266": ["S", 1.648e-05, ' '2, 121350, 0, "missense", "deleterious", "#e30e0e", ' '""], "265": ["R", 1.648e-05, 2, 121352, 0, "missense", ' '"deleterious", "#e30e0e", "LB (hydrophobic) "], "254": ' '["F", 0.0001648, 20, 121346, 0, "missense", ' '"deleterious", "#e30e0e", "SodiumPocket MicroSwitch ' '"], "250": ["L", 8.246e-06, 1, 121274, 0, "missense", ' '"tolerated", "#70c070", "GP (contact) "], "248": ["R", ' '1.65e-05, 2, 121246, 0, "missense", "deleterious", ' '"#e30e0e", ""], "244": ["V", 0.000132, 16, 121176, 0, ' '"missense", "deleterious", "#e30e0e", "SodiumPocket ' 'MicroSwitch "], "242": ["M", 8.26e-06, 1, 121062, 0, ' '"missense", "tolerated", "#70c070", "GP (contact) "], ' '"233": ["E", 8.291e-06, 1, 120610, 0, "missense", ' '"deleterious", "#e30e0e", ""], "229": ["K", 8.304e-06, ' '1, 120426, 0, "missense", "tolerated", "#70c070", ""], ' '"228": ["N", 2.492e-05, 3, 120370, 0, "missense", ' '"tolerated", "#70c070", ""], "218": ["R", 8.428e-06, ' '1, 118654, 0, "missense", "tolerated", "#70c070", "GP ' '(contact) "], "216": ["V", 5.066e-05, 6, 118440, 0, ' '"missense", "deleterious", "#e30e0e", "GP (contact) ' '"], "211": ["L", 8.464e-06, 1, 118142, 0, "missense", ' '"deleterious", "#e30e0e", ""], "210": ["R", 8.476e-06, ' '1, 117986, 0, "missense", "deleterious", "#e30e0e", ' '""], "204": ["R", 3.4e-05, 4, 117650, 0, "missense", ' '"deleterious", "#e30e0e", ""], "203": ["C", 8.503e-06, ' '1, 117608, 0, "missense", "tolerated", "#70c070", ""], ' '"199": ["T", 9.378e-05, 11, 117298, 0, "missense", ' '"tolerated", "#70c070", ""], "190": ["C", 8.573e-06, ' '1, 116644, 0, "missense", "deleterious", "#e30e0e", ' '"LB (polar (hydrogen bond)) "], "186": ["N", ' '8.608e-06, 1, 116166, 0, "missense", "deleterious", ' '"#e30e0e", ""], "178": ["T", 2.594e-05, 3, 115670, 0, ' '"missense", "tolerated", "#70c070", ""], "174": ["Y", ' '8.648e-06, 1, 115638, 0, "missense", "deleterious", ' '"#e30e0e", ""], "164": ["I", 8.547e-06, 1, 116994, 0, ' '"missense", "tolerated", "#70c070", ""], "159": ["F", ' '8.459e-06, 1, 118216, 0, "missense", "tolerated", ' '"#70c070", ""], "158": ["C", 8.449e-06, 1, 118354, 0, ' '"missense", "deleterious", "#e30e0e", ""], "155": ' '["S", 8.264e-06, 1, 121006, 0, "missense", ' '"tolerated", "#70c070", ""], "154": ["V", 8.262e-06, ' '1, 121036, 0, "missense", "deleterious", "#e30e0e", ' '""], "148": ["R", 8.252e-06, 1, 121188, 0, "missense", ' '"tolerated", "#70c070", ""], "147": ["H", 6.602e-05, ' '8, 121178, 0, "missense", "tolerated", "#70c070", ""], ' '"144": ["Q", 8.249e-06, 1, 121228, 0, "missense", ' '"deleterious", "#e30e0e", "GP (contact) "], "142": ' '["R", 8.248e-06, 1, 121242, 0, "missense", ' '"deleterious", "#e30e0e", "GP (contact) "], "139": ' '["T", 8.247e-06, 1, 121256, 0, "missense", ' '"tolerated", "#70c070", "GP (contact) "], "137": ["C", ' '8.246e-06, 1, 121264, 0, "missense", "deleterious", ' '"#e30e0e", "PTM (Phosphorylation) GP (contact) "], ' '"136": ["C", 6.597e-05, 8, 121272, 0, "missense", ' '"tolerated", "#70c070", "GP (contact) "], "134": ["Y", ' '8.246e-06, 1, 121270, 0, "missense", "deleterious", ' '"#e30e0e", "GP (contact) "], "133": ["I", 0.003636, ' '441, 121284, 3, "missense", "deleterious", "#e30e0e", ' '""], "128": ["S", 8.245e-06, 1, 121292, 0, "missense", ' '"deleterious", "#e30e0e", ""], "119": ["D", 8.242e-06, ' '1, 121336, 0, "missense", "deleterious", "#e30e0e", ' '""], "117": ["S", 8.241e-06, 1, 121342, 0, "missense", ' '"deleterious", "#e30e0e", "LB (aromatic ' '(face-to-edge)) "], "114": ["P", 8.241e-06, 1, 121346, ' '0, "missense", "deleterious", "#e30e0e", "PTM ' '(Phosphorylation) "], "113": ["M", 8.241e-06, 1, ' '121350, 0, "missense", "deleterious", "#e30e0e", "LB ' '(hydrophobic) "], "111": ["S", 1.648e-05, 2, 121348, ' '0, "missense", "deleterious", "#e30e0e", ""], "110": ' '["T", 0.0002555, 31, 121352, 0, "missense", ' '"deleterious", "#e30e0e", ""], "101": ["A", 8.24e-06, ' '1, 121352, 0, "missense", "deleterious", "#e30e0e", ' '""], "95": ["R", 8.24e-06, 1, 121354, 0, "missense", ' '"deleterious", "#e30e0e", ""], "92": ["M", 8.24e-06, ' '1, 121354, 0, "missense", "deleterious", "#e30e0e", ' '""], "90": ["N", 8.24e-06, 1, 121356, 0, "missense", ' '"tolerated", "#70c070", ""], "89": ["R", 8.24e-06, 1, ' '121358, 0, "missense", "tolerated", "#70c070", ""], ' '"84": ["C", 4.12e-05, 5, 121350, 0, "missense", ' '"deleterious", "#e30e0e", ""], "74": ["C", 8.24e-06, ' '1, 121358, 0, "missense", "deleterious", "#e30e0e", ' '""], "70": ["H", 4.944e-05, 6, 121354, 0, "missense", ' '"deleterious", "#e30e0e", ""], "66": ["W", 4.128e-05, ' '5, 121114, 0, "missense", "deleterious", "#e30e0e", ' '""], "65": ["C", 0.0001237, 15, 121238, 0, "missense", ' '"deleterious", "#e30e0e", ""], "62": ["R", 8.243e-06, ' '1, 121310, 0, "missense", "tolerated", "#70c070", ""], ' '"61": ["F", 1.648e-05, 2, 121324, 0, "missense", ' '"deleterious", "#e30e0e", ""], "52": ["M", 5.772e-05, ' '7, 121270, 0, "missense", "tolerated", "#70c070", ""], ' '"47": ["R", 8.248e-06, 1, 121242, 0, "missense", ' '"deleterious", "#e30e0e", ""], "40": ["Y", 3.303e-05, ' '4, 121094, 0, "missense", "deleterious", "#e30e0e", ' '""], "30": ["D", 9.938e-05, 12, 120750, 0, "missense", ' '"tolerated", "#70c070", ""], "29": ["R", 8.284e-06, 1, ' '120716, 0, "missense", "deleterious", "#e30e0e", "PTM ' '(Phosphorylation) "], "22": ["L", 8.337e-06, 1, ' '119954, 0, "missense", "tolerated", "#70c070", ""], ' '"20": ["S", 2.507e-05, 3, 119646, 0, "missense", ' '"tolerated", "#70c070", ""], "18": ["V", 8.414e-06, 1, ' '118848, 0, "missense", "deleterious", "#e30e0e", ""], ' '"16": ["V", 8.457e-06, 1, 118244, 0, "missense", ' '"deleterious", "#e30e0e", ""], "15": ["Y", 4.245e-05, ' '5, 117788, 0, "missense", "deleterious", "#e30e0e", ' '""], "11": ["S", 1.718e-05, 2, 116444, 0, "missense", ' '"deleterious", "#e30e0e", ""], "9": ["T", 1.73e-05, 2, ' '115616, 0, "missense", "tolerated", "#70c070", ""], ' '"4": ["Y", 8.846e-06, 1, 113046, 0, "missense", ' '"deleterious", "#e30e0e", ""]}', 'natural_mutations_pos_list': '{"29": {"val": 1, "AA": "R "}, "30": {"val": ' '1, "AA": "D "}, "40": {"val": 1, "AA": "Y "}, ' '"47": {"val": 1, "AA": "R "}, "52": {"val": 1, ' '"AA": "M "}, "61": {"val": 1, "AA": "F "}, ' '"62": {"val": 1, "AA": "R "}, "63": {"val": 3, ' '"AA": "Ter R K "}, "65": {"val": 2, "AA": "H C ' '"}, "70": {"val": 1, "AA": "H "}, "74": ' '{"val": 1, "AA": "C "}, "84": {"val": 1, "AA": ' '"C "}, "89": {"val": 2, "AA": "Y R "}, "90": ' '{"val": 1, "AA": "N "}, "92": {"val": 1, "AA": ' '"M "}, "95": {"val": 1, "AA": "R "}, "110": ' '{"val": 2, "AA": "M T "}, "111": {"val": 1, ' '"AA": "S "}, "113": {"val": 1, "AA": "M "}, ' '"114": {"val": 1, "AA": "P "}, "117": {"val": ' '1, "AA": "S "}, "119": {"val": 1, "AA": "D "}, ' '"128": {"val": 1, "AA": "S "}, "131": {"val": ' '2, "AA": "Ter Q "}, "132": {"val": 1, "AA": ' '"Ter "}, "133": {"val": 1, "AA": "I "}, "134": ' '{"val": 1, "AA": "Y "}, "136": {"val": 2, ' '"AA": "H C "}, "137": {"val": 1, "AA": "C "}, ' '"139": {"val": 1, "AA": "T "}, "142": {"val": ' '1, "AA": "R "}, "144": {"val": 1, "AA": "Q "}, ' '"147": {"val": 1, "AA": "H "}, "148": {"val": ' '1, "AA": "R "}, "154": {"val": 1, "AA": "V "}, ' '"155": {"val": 1, "AA": "S "}, "158": {"val": ' '1, "AA": "C "}, "159": {"val": 1, "AA": "F "}, ' '"164": {"val": 1, "AA": "I "}, "190": {"val": ' '1, "AA": "C "}, "194": {"val": 1, "AA": "Ter ' '"}, "199": {"val": 2, "AA": "G T "}, "203": ' '{"val": 1, "AA": "C "}, "204": {"val": 1, ' '"AA": "R "}, "210": {"val": 1, "AA": "R "}, ' '"211": {"val": 2, "AA": "Q L "}, "216": ' '{"val": 1, "AA": "V "}, "218": {"val": 2, ' '"AA": "H R "}, "242": {"val": 2, "AA": "S M ' '"}, "244": {"val": 2, "AA": "D V "}, "248": ' '{"val": 2, "AA": "V R "}, "250": {"val": 1, ' '"AA": "L "}, "254": {"val": 1, "AA": "F "}, ' '"255": {"val": 1, "AA": "SerfsTer66 "}, "257": ' '{"val": 1, "AA": "GlyfsTer20 "}, "265": ' '{"val": 1, "AA": "R "}, "266": {"val": 1, ' '"AA": "S "}, "270": {"val": 1, "AA": "D "}, ' '"271": {"val": 1, "AA": "A "}, "275": {"val": ' '2, "AA": "E A "}, "280": {"val": 1, "AA": "V ' '"}, "285": {"val": 1, "AA": "F "}, "290": ' '{"val": 1, "AA": "V "}, "297": {"val": 1, ' '"AA": "I "}, "302": {"val": 1, "AA": "W "}, ' '"306": {"val": 1, "AA": "V "}, "307": {"val": ' '3, "AA": "H C G "}, "308": {"val": 1, "AA": "F ' '"}, "313": {"val": 1, "AA": "Y "}, "315": ' '{"val": 1, "AA": "V "}, "316": {"val": 2, ' '"AA": "Y N "}, "color": ["#c79494", "#c54a4a", ' '"#c40100"]}', 'receptor': 'cnr2_human', 'type': 'protein'} {'hosts': {'arrestin': '', 'gpcr': '', 'gprotein': ''}}

Context processors

django.template.context_processors.csrf: Toggle context
{'csrf_token': <SimpleLazyObject: 'DW7SvhO307eev9jnXnboz2mgyd5PyhXmO8CdzWfXevEyqjLlKUNW7Vx1J6uYgTCB'>}
django.contrib.auth.context_processors.auth: Toggle context
{'user': <SimpleLazyObject: <django.contrib.auth.models.AnonymousUser object at 0x7f2e73a763c8>>, 'perms': <django.contrib.auth.context_processors.PermWrapper object at 0x7f2e73a77518>}
django.template.context_processors.debug: Toggle context
{'debug': True, 'sql_queries': <function debug.<locals>.<lambda> at 0x7f2e7355fe18>}
django.template.context_processors.i18n: Toggle context
{'LANGUAGES': [('af', 'Afrikaans'), ('ar', 'Arabic'), ('ast', 'Asturian'), ('az', 'Azerbaijani'), ('bg', 'Bulgarian'), ('be', 'Belarusian'), ('bn', 'Bengali'), ('br', 'Breton'), ('bs', 'Bosnian'), ('ca', 'Catalan'), ('cs', 'Czech'), ('cy', 'Welsh'), ('da', 'Danish'), ('de', 'German'), ('dsb', 'Lower Sorbian'), ('el', 'Greek'), ('en', 'English'), ('en-au', 'Australian English'), ('en-gb', 'British English'), ('eo', 'Esperanto'), ('es', 'Spanish'), ('es-ar', 'Argentinian Spanish'), ('es-co', 'Colombian Spanish'), ('es-mx', 'Mexican Spanish'), ('es-ni', 'Nicaraguan Spanish'), ('es-ve', 'Venezuelan Spanish'), ('et', 'Estonian'), ('eu', 'Basque'), ('fa', 'Persian'), ('fi', 'Finnish'), ('fr', 'French'), ('fy', 'Frisian'), ('ga', 'Irish'), ('gd', 'Scottish Gaelic'), ('gl', 'Galician'), ('he', 'Hebrew'), ('hi', 'Hindi'), ('hr', 'Croatian'), ('hsb', 'Upper Sorbian'), ('hu', 'Hungarian'), ('hy', 'Armenian'), ('ia', 'Interlingua'), ('id', 'Indonesian'), ('io', 'Ido'), ('is', 'Icelandic'), ('it', 'Italian'), ('ja', 'Japanese'), ('ka', 'Georgian'), ('kab', 'Kabyle'), ('kk', 'Kazakh'), ('km', 'Khmer'), ('kn', 'Kannada'), ('ko', 'Korean'), ('lb', 'Luxembourgish'), ('lt', 'Lithuanian'), ('lv', 'Latvian'), ('mk', 'Macedonian'), ('ml', 'Malayalam'), ('mn', 'Mongolian'), ('mr', 'Marathi'), ('my', 'Burmese'), ('nb', 'Norwegian Bokmål'), ('ne', 'Nepali'), ('nl', 'Dutch'), ('nn', 'Norwegian Nynorsk'), ('os', 'Ossetic'), ('pa', 'Punjabi'), ('pl', 'Polish'), ('pt', 'Portuguese'), ('pt-br', 'Brazilian Portuguese'), ('ro', 'Romanian'), ('ru', 'Russian'), ('sk', 'Slovak'), ('sl', 'Slovenian'), ('sq', 'Albanian'), ('sr', 'Serbian'), ('sr-latn', 'Serbian Latin'), ('sv', 'Swedish'), ('sw', 'Swahili'), ('ta', 'Tamil'), ('te', 'Telugu'), ('th', 'Thai'), ('tr', 'Turkish'), ('tt', 'Tatar'), ('udm', 'Udmurt'), ('uk', 'Ukrainian'), ('ur', 'Urdu'), ('vi', 'Vietnamese'), ('zh-hans', 'Simplified Chinese'), ('zh-hant', 'Traditional Chinese')], 'LANGUAGE_CODE': 'en-us', 'LANGUAGE_BIDI': False}
django.template.context_processors.media: Toggle context
{'MEDIA_URL': '/media/'}
django.template.context_processors.static: Toggle context
{'STATIC_URL': '/static/'}
django.template.context_processors.tz: Toggle context
{'TIME_ZONE': 'Europe/Copenhagen'}
django.contrib.messages.context_processors.messages: Toggle context
{'messages': <django.contrib.messages.storage.fallback.FallbackStorage object at 0x7f2e73a76eb8>, 'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30, 'ERROR': 40}}
protwis.context_processors.current_site: Toggle context
{'current_site': 'gpcr'}
protwis.context_processors.canonical_tag: Toggle context
{'canonical_tag': 'https://gpcrdb.org/mutational_landscape/protein/CNR2_human/'}
protwis.context_processors.documentation_url: Toggle context
{'documentation_url': 'https://docs.gpcrdb.org/'}
protwis.context_processors.google_analytics: Toggle context
{}
protwis.context_processors.site_title: Toggle context
{'site_title': 'GPCRdb'}

Cache calls from 2 backends

Summary

Total calls	Total time	Cache hits	Cache misses
3	23.00262451171875 ms	2	0

Commands

add	get	set	delete	clear	get_many	set_many	delete_many	has_key	incr	decr	incr_version	decr_version
0	2	0	0	0	0	0	0	1	0	0	0	0

Calls

Time (ms)		Type	Arguments	Keyword arguments	Backend
+	0.9174	has_key	('VARIATION_61d32ca4609e6a609537ec32cb867161',)	{}	<django.core.cache.backends.filebased.FileBasedCache object at 0x7f2e73a769b0>
	/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(122) if not cache_variation.has_key(cache_key) and len(proteins)>0:
+	21.9500	get	('VARIATION_61d32ca4609e6a609537ec32cb867161',)	{}	<django.core.cache.backends.filebased.FileBasedCache object at 0x7f2e73a769b0>
	/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(252) cache_data = cache_variation.get(cache_key)
+	0.1352	get	('citation_urls',)	{}	<django.core.cache.backends.filebased.FileBasedCache object at 0x7f2e73a769b0>
	/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(292) return render(request, 'browser.html', cache_data) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/shortcuts.py in render(36) content = loader.render_to_string(template_name, context, request, using=using) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/template/loader.py in render_to_string(62) return template.render(context, request) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/template/backends/django.py in render(61) return self.template.render(context) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/template/base.py in render(169) with context.bind_template(self): /usr/lib/python3.6/contextlib.py in __enter__(81) return next(self.gen) /home/protwis/gpcrdb_test/protwis/context_processors.py in canonical_tag(31) citation_dict = cache.get("citation_urls")

Signals

Signal	Providing	Receivers
class_prepared	class
connection_created	connection
got_request_exception	request
post_delete	instance, using
post_init	instance
post_migrate	app_config, plan, interactive, verbosity, apps, using	create_permissions, create_contenttypes
post_save	created, raw, instance, update_fields, using
pre_delete	instance, using
pre_init	instance, args, kwargs
pre_save	instance, using, update_fields, raw
request_finished		close_old_connections, close_caches, reset_urlconf
request_started	environ	reset_queries, close_old_connections

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