Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
drd4_human 62 1.60x60 TM1 E => Ter stop gained 6.277e-05 1 15930 0 None None
drd4_human 79 2.49x49 TM2 A => SerfsTer21 frameshift 0.009316 199 21360 1 None None
drd4_human 84 2.54x54 TM2 A => LeufsTer20 frameshift 0.0001405 3 21350 0 None None
drd4_human 172 4.62x63 TM4 C => Ter stop gained 1.602e-05 1 62406 0 None None
drd4_human 369 6.58x58 TM6 Q => Ter stop gained 8.507e-06 1 117552 0 None None
drd4_human 404 8.47x47 H8 N => LysfsTer46 frameshift 2.523e-05 3 118896 0 None None GP (contact)
drd4_human 418 C-term C => TrpfsTer31 frameshift 8.479e-06 1 117944 0 None None
drd4_human 35 1.33x33 TM1 A => V missense 0.000664 2 3012 0 0.5 0.0
drd4_human 41 1.39x39 TM1 G => V missense 0.0001211 1 8260 0 0.06 0.0
drd4_human 47 1.45x45 TM1 A => T missense 0.0001733 2 11544 0 0.37 0.0
drd4_human 50 1.48x48 TM1 A => S missense 8.201e-05 1 12194 0 0.48 0.0
drd4_human 53 1.51x51 TM1 S => L missense 7.595e-05 1 13166 0 0.46 0.0
drd4_human 62 1.60x60 TM1 E => K missense 6.277e-05 1 15930 0 0.0 0.0
drd4_human 62 1.60x60 TM1 E => D missense 6.182e-05 1 16176 0 0.0 0.0
drd4_human 63 12.48x48 ICL1 R => P missense 6.06e-05 1 16502 0 0.0 0.0 PTM (Methylation)
drd4_human 63 12.48x48 ICL1 R => H missense 6.06e-05 1 16502 0 0.0 0.0 PTM (Methylation)
drd4_human 67 2.37x37 TM2 T => M missense 0.0006367 12 18848 1 0.0 0.0
drd4_human 68 2.38x38 TM2 P => A missense 5.177e-05 1 19316 0 0.44 0.0
drd4_human 72 2.42x42 TM2 F => L missense 4.789e-05 1 20880 0 0.36 0.0
drd4_human 73 2.43x43 TM2 I => N missense 4.74e-05 1 21098 0 0.0 0.0
drd4_human 74 2.44x44 TM2 V => M missense 9.417e-05 2 21238 0 0.01 0.0
drd4_human 77 2.47x47 TM2 A => V missense 4.811e-05 1 20784 0 0.0 0.0
drd4_human 78 2.48x48 TM2 A => T missense 0.001919 41 21360 0 0.06 0.0
drd4_human 79 2.49x49 TM2 A => S missense 9.65e-05 2 20726 0 0.11 0.0
drd4_human 81 2.51x51 TM2 L => V missense 4.757e-05 1 21022 0 0.0 0.0
drd4_human 81 2.51x51 TM2 L => H missense 4.759e-05 1 21014 0 0.0 0.0
drd4_human 81 2.51x51 TM2 L => P missense 4.759e-05 1 21014 0 0.03 0.0
drd4_human 82 2.52x52 TM2 L => F missense 4.787e-05 1 20892 0 0.01 0.0
drd4_human 84 2.54x54 TM2 A => T missense 0.000802 17 21196 0 0.0 0.0
drd4_human 86 2.56x551 TM2 L => P missense 9.538e-05 2 20968 0 0.0 0.0
drd4_human 89 2.59x58 TM2 P => T missense 4.914e-05 1 20352 0 0.01 0.0
drd4_human 89 2.59x58 TM2 P => L missense 4.968e-05 1 20128 0 0.0 0.0
drd4_human 91 2.61x60 TM2 F => I missense 5.046e-05 1 19818 0 0.03 0.0 LB (aromatic (edge-to-face))
drd4_human 93 2.63x62 TM2 Y => H missense 0.0001039 2 19254 0 0.0 0.0
drd4_human 95 2.65x64 TM2 E => K missense 0.0003716 7 18838 0 0.0 0.0
drd4_human 95 2.65x64 TM2 E => G missense 5.289e-05 1 18908 0 0.01 0.0
drd4_human 97 2.67x66 TM2 Q => E missense 1.829e-05 1 54672 0 0.27 0.0
drd4_human 98 2.68x67 TM2 G => D missense 1.713e-05 1 58386 0 0.17 0.0 LB (hydrophobic)
drd4_human 105 3.22x22 TM3 P => T missense 1.276e-05 1 78368 0 1.0 0.0
drd4_human 106 3.23x23 TM3 R => C missense 0.0004652 38 81688 1 0.17 0.0
drd4_human 106 3.23x23 TM3 R => H missense 2.423e-05 2 82552 0 0.54 0.0
drd4_human 108 3.25x25 TM3 C => Y missense 1.158e-05 1 86328 0 0.0 0.0
drd4_human 109 3.26x26 TM3 D => H missense 1.142e-05 1 87564 0 0.0 0.0 LB (hydrophobic)
drd4_human 110 3.27x27 TM3 A => T missense 1.117e-05 1 89512 0 0.25 0.0
drd4_human 110 3.27x27 TM3 A => P missense 1.117e-05 1 89512 0 0.09 0.0
drd4_human 112 3.29x29 TM3 M => L missense 2.174e-05 2 92012 0 0.1 0.0 LB (polar (hydrogen bond), polar (charge-assisted hydrogen bond))
drd4_human 112 3.29x29 TM3 M => K missense 1.083e-05 1 92322 0 0.0 0.0 LB (polar (hydrogen bond), polar (charge-assisted hydrogen bond))
drd4_human 112 3.29x29 TM3 M => I missense 4.326e-05 4 92454 0 0.01 0.0 LB (polar (hydrogen bond), polar (charge-assisted hydrogen bond))
drd4_human 113 3.30x30 TM3 A => P missense 1.079e-05 1 92684 0 0.0 0.0 LB (hydrophobic, Van der Waals)
drd4_human 114 3.31x31 TM3 M => T missense 8.552e-05 8 93540 0 0.0 0.0
drd4_human 115 3.32x32 TM3 D => H missense 0.0002024 19 93864 0 0.0 0.0 LB (polar (charge-assisted hydrogen bond))
drd4_human 116 3.33x33 TM3 V => I missense 2.132e-05 2 93828 0 0.0 0.0 LB (hydrophobic, Van der Waals, polar (hydrogen bond with backbone))
drd4_human 116 3.33x33 TM3 V => F missense 1.066e-05 1 93828 0 0.0 0.0 LB (hydrophobic, Van der Waals, polar (hydrogen bond with backbone))
drd4_human 117 3.34x34 TM3 M => T missense 1.065e-05 1 93920 0 0.0 0.0
drd4_human 118 3.35x35 TM3 L => P missense 0.0001277 12 93990 0 0.0 0.0
drd4_human 119 3.36x36 TM3 C => Y missense 1.067e-05 1 93740 0 0.0 0.0 LB (hydrophobic, Van der Waals, polar (hydrogen bond))
drd4_human 122 3.39x39 TM3 S => F missense 3.238e-05 3 92656 0 0.0 0.0
drd4_human 122 3.39x39 TM3 S => C missense 1.079e-05 1 92656 0 0.0 0.0
drd4_human 124 3.41x41 TM3 F => S missense 1.089e-05 1 91854 0 0.0 0.0
drd4_human 127 3.44x44 TM3 C => Y missense 6.85e-05 6 87588 0 0.0 0.0
drd4_human 128 3.45x45 TM3 A => T missense 1.146e-05 1 87236 0 0.0 0.0
drd4_human 129 3.46x46 TM3 I => S missense 5.844e-05 5 85554 0 0.0 0.0
drd4_human 130 3.47x47 TM3 S => G missense 1.199e-05 1 83432 0 0.0 0.0
drd4_human 131 3.48x48 TM3 V => A missense 1.245e-05 1 80346 0 0.02 0.0
drd4_human 140 34.50x50 ICL2 P => Q missense 9.823e-05 1 10180 0 0.0 0.0 GP (contact)
drd4_human 144 34.54x54 ICL2 N => K missense 9.645e-05 1 10368 0 0.0 0.0 GP (contact)
drd4_human 156 4.46x46 TM4 I => T missense 0.0004091 6 14668 0 0.0 0.0
drd4_human 157 4.47x47 TM4 G => D missense 0.0008102 13 16046 0 0.03 0.0
drd4_human 162 4.52x52 TM4 L => M missense 8.872e-05 2 22544 0 0.01 0.0
drd4_human 166 4.56x56 TM4 V => G missense 3.113e-05 1 32122 0 0.0 0.0
drd4_human 167 4.57x57 TM4 A => V missense 8.477e-05 3 35388 0 0.0 0.0
drd4_human 168 4.58x59 TM4 A => T missense 5.103e-05 2 39192 0 0.09 0.0
drd4_human 169 4.59x60 TM4 P => S missense 4.482e-05 2 44622 0 0.0 0.0
drd4_human 170 4.60x61 TM4 V => L missense 1.993e-05 1 50186 0 0.33 0.0
drd4_human 170 4.60x61 TM4 V => I missense 1.993e-05 1 50186 0 0.15 0.0
drd4_human 173 4.63x64 TM4 G => S missense 1.535e-05 1 65132 0 0.0 0.0
drd4_human 173 4.63x64 TM4 G => C missense 3.071e-05 2 65132 0 0.0 0.0
drd4_human 175 ECL2 N => S missense 2.69e-05 2 74336 0 0.0 0.0
drd4_human 177 ECL2 V => L missense 1.228e-05 1 81418 0 0.01 0.0
drd4_human 180 ECL2 R => C missense 1.08e-05 1 92616 0 0.0 0.0
drd4_human 181 ECL2 D => A missense 1.027e-05 1 97388 0 0.0 0.0
drd4_human 182 ECL2 P => S missense 1.006e-05 1 99430 0 0.01 0.0
drd4_human 187 45.52x52 ECL2 L => V missense 9.221e-06 1 108452 0 0.0 0.0 LB (hydrophobic, Van der Waals)
drd4_human 190 5.36x37 TM5 R => C missense 9.021e-06 1 110848 0 0.04 0.0
drd4_human 190 5.36x37 TM5 R => S missense 9.021e-06 1 110848 0 0.43 0.0
drd4_human 191 5.37x38 TM5 D => A missense 8.951e-06 1 111722 0 0.16 0.0
drd4_human 194 5.40x41 TM5 V => G missense 0.00462 522 112976 9 0.0 0.0
drd4_human 196 5.42x43 TM5 S => L missense 8.816e-06 1 113430 0 0.0 0.0 LB (polar (hydrogen bond), polar (hydrogen bond with backbone))
drd4_human 199 5.45x46 TM5 C => Y missense 6.146e-05 7 113892 0 0.0 0.0
drd4_human 200 5.46x461 TM5 S => F missense 2.632e-05 3 113998 0 0.0 0.0 LB (Van der Waals, polar (hydrogen bond))
drd4_human 201 5.47x47 TM5 F => S missense 9.645e-05 11 114046 0 0.0 0.0 SodiumPocket MicroSwitch
drd4_human 206 5.52x52 TM5 P => Q missense 8.767e-06 1 114060 0 0.01 0.0
drd4_human 211 5.57x57 TM5 L => F missense 1.759e-05 2 113704 0 0.0 0.0
drd4_human 212 5.58x58 TM5 Y => C missense 0.0003701 42 113478 1 0.0 0.0 SodiumPocket MicroSwitch
drd4_human 214 5.60x60 TM5 A => T missense 2.655e-05 3 112980 0 0.11 0.0
drd4_human 214 5.60x60 TM5 A => V missense 8.85e-06 1 113000 0 0.09 0.0
drd4_human 217 5.63x63 TM5 R => C missense 8.902e-06 1 112334 0 0.01 0.0
drd4_human 218 5.64x64 TM5 G => C missense 9.836e-05 11 111830 0 0.02 0.0 GP (contact)
drd4_human 218 5.64x64 TM5 G => S missense 8.942e-06 1 111830 0 0.13 0.0 GP (contact)
drd4_human 221 5.67x67 TM5 R => H missense 9.059e-06 1 110384 0 0.03 0.0 GP (contact)
drd4_human 222 5.68x68 TM5 W => S missense 9.08e-06 1 110130 0 0.01 0.0 GP (contact)
drd4_human 226 5.72x72 TM5 R => C missense 9.373e-06 1 106688 0 0.0 0.0 GP (contact)
drd4_human 226 5.72x72 TM5 R => G missense 3.749e-05 4 106688 0 0.02 0.0 GP (contact)
drd4_human 227 5.73x73 TM5 R => C missense 2.857e-05 3 105006 0 0.0 0.0
drd4_human 227 5.73x73 TM5 R => H missense 6.905e-05 7 101370 0 0.09 0.0
drd4_human 227 5.73x73 TM5 R => P missense 9.865e-06 1 101370 0 0.0 0.0
drd4_human 228 5.74x74 TM5 A => V missense 4.131e-05 4 96822 0 0.12 0.0 GP (contact)
drd4_human 232 ICL3 G => S missense 0.0002469 7 28354 0 1.0 0.0
drd4_human 232 ICL3 G => R missense 3.527e-05 1 28354 0 0.38 0.0
drd4_human 233 ICL3 R => H missense 4.517e-05 1 22140 0 0.1 0.0
drd4_human 233 ICL3 R => P missense 4.517e-05 1 22140 0 0.07 0.0
drd4_human 235 ICL3 P => L missense 1.436e-05 1 69652 0 0.83 0.0
drd4_human 236 ICL3 R => H missense 3.065e-05 2 65260 0 0.09 0.0
drd4_human 240 ICL3 G => S missense 0.001219 49 40208 0 0.42 0.0
drd4_human 240 ICL3 G => A missense 5.768e-05 2 34672 0 0.51 0.0
drd4_human 240 ICL3 G => D missense 2.884e-05 1 34672 0 0.28 0.0
drd4_human 241 ICL3 P => R missense 3.098e-05 1 32274 0 0.2 0.0
drd4_human 242 ICL3 G => A missense 3.688e-05 1 27114 0 0.79 0.0
drd4_human 255 ICL3 Q => P missense 0.004464 1 224 0 0.16 0.0
drd4_human 268 ICL3 G => C missense 0.05556 1 18 0 0.09 0.0
drd4_human 272 ICL3 G => V missense 0.0625 1 16 0 0.25 0.0
drd4_human 310 ICL3 C => R missense 0.001111 10 8998 0 0.66 0.588
drd4_human 313 ICL3 P => R missense 0.007434 73 9820 0 0.51 0.904
drd4_human 339 6.28x28 TM6 G => D missense 0.001891 22 11636 1 0.03 0.889 GP (contact)
drd4_human 358 6.47x47 TM6 C => W missense 9.605e-05 11 114526 0 0.0 0.994 LB (Van der Waals)
drd4_human 364 6.53x53 TM6 V => L missense 8.569e-06 1 116704 0 0.09 0.972
drd4_human 364 6.53x53 TM6 V => M missense 8.569e-06 1 116704 0 0.0 0.994
drd4_human 386 7.39x38 TM7 T => P missense 1.684e-05 2 118762 0 0.0 0.994 LB (polar (hydrogen bond with backbone), Van der Waals)
drd4_human 386 7.39x38 TM7 T => I missense 8.42e-06 1 118770 0 0.0 0.994 LB (polar (hydrogen bond with backbone), Van der Waals)
drd4_human 397 7.50x50 TM7 P => L missense 8.403e-06 1 119000 0 0.0 0.996 SodiumPocket MicroSwitch
drd4_human 403 7.56x56 TM7 F => L missense 8.41e-06 1 118904 0 0.0 0.961 GP (contact)
drd4_human 411 8.54x54 H8 F => L missense 8.437e-06 1 118524 0 0.0 0.961 LB (hydrophobic, Van der Waals)


Residue

Diagrams

ICL1 R A L Q ICL1ECL1 G A W L L ECL1ICL2 P L R Y N R Q G ICL2ECL2 L N D V R G R D P A V C R L E ECL2ICL3 L H G R A P R R P S G P G P P S P T P P A P R L P Q D P C G P D C A P P A P G L P R G P C G P D C A P A A P S L P Q D P C G P D C A P P A P G L P P D P C G S N C A P P D A V R A A A L P P Q T P P Q T R R R R R ICL3ECL3 P A C S V ECL3N-term M G N R S T A D A D G L L A G R G P A A G A S A G A S A G L N-termC-term A C C C-term A G Q G A A A L V G G V L L I G A V L A G N S L V C V S V A T E T P T N S F I V S L A A A D L L L A L L V L P L F V Y S E V Q G S P R L C D A L M A M D V M L C T A S I F N L C A I S V D R F V A V A V G S R R Q L L L I G A T W L L S A A V A A P V L C G D R D Y V V Y S S V C S F F L P C P L M L L L Y W A T F R G L Q R W E V A R R A K A K I T G R E R K A M R V L P V V V G A F L L C W T P F F V V H I T Q A L C P P R L V S A V T W L G Y V N S A L N P V I Y T V F N A E F R K F R N V A L R
SnakePlot Download: PNG | SVG S N G A L V A G I L L V G G V L A A A G 1 V S L A A A D L L L A L L V L P L F V Y S 2 A C L N F I S A T C L M V D M A M L A D 3 Q L L L I G A T W L L S A A V A A P V 4 Y L L L M L P C P L F F S C V S S Y V V Y 5 P V V V G A F L L C W T P F F V V H I T 6 V P N L A S N V Y G L W T V A S V L R 7
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