GPCRdb

Variation Browser

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Receptor	Position	GPCRdb	Segment	Variant	Mutation type	Allele Frequency	Allele Count	Allele Number	Homozygotes	SIFT score	PolyPhen score	Functional annotation


Receptor	Position	GPCRdb	Segment	Variant	Mutation Type	Allele Frequency	Allele Count	Allele Number	Homozygotes	SIFT score	PolyPhen score	Functional annotation
pe2r4_human	305		ECL3	E => Ter	stop gained	8.252e-06	1	121190	0	None	None
pe2r4_human	8		N-term	S => L	missense	8.621e-06	1	115996	0	0.14	0.002
pe2r4_human	10		N-term	A => V	missense	1.705e-05	2	117318	0	0.19	0.013
pe2r4_human	11		N-term	S => F	missense	8.485e-05	10	117850	0	0.02	0.035
pe2r4_human	13		N-term	S => G	missense	8.439e-06	1	118500	0	0.44	0.001
pe2r4_human	14		N-term	P => A	missense	8.425e-06	1	118690	0	0.18	0.001
pe2r4_human	15		N-term	D => H	missense	8.404e-06	1	118996	0	0.12	0.002
pe2r4_human	26	1.41x41	TM1	V => L	missense	8.317e-06	1	120238	0	0.22	0.004
pe2r4_human	29	1.44x44	TM1	I => V	missense	8.302e-06	1	120446	0	0.2	0.04
pe2r4_human	29	1.44x44	TM1	I => L	missense	8.302e-06	1	120446	0	0.07	0.008
pe2r4_human	32	1.47x47	TM1	V => A	missense	8.295e-06	1	120558	0	0.09	0.573
pe2r4_human	39	1.54x54	TM1	I => M	missense	8.272e-06	1	120886	0	0.0	0.987
pe2r4_human	74	2.59x58	TM2	P => S	missense	8.254e-06	1	121148	0	0.0	0.88
pe2r4_human	79	2.64x63	TM2	T => R	missense	8.258e-06	1	121094	0	0.0	0.038
pe2r4_human	81	2.66x65	TM2	M => L	missense	8.259e-06	1	121078	0	0.6	0.001
pe2r4_human	96	3.29x29	TM3	T => S	missense	8.253e-06	1	121166	0	1.0	0.01
pe2r4_human	101	3.34x34	TM3	F => L	missense	8.253e-06	1	121172	0	0.0	0.74
pe2r4_human	109	3.42x42	TM3	I => F	missense	1.651e-05	2	121168	0	0.03	0.809
pe2r4_human	112	3.45x45	TM3	A => T	missense	8.254e-06	1	121160	0	0.07	0.753
pe2r4_human	126	34.52x52	ICL2	F => L	missense	1.652e-05	2	121070	0	0.09	0.062	GP (contact)
pe2r4_human	129	34.55x55	ICL2	H => Q	missense	3.303e-05	4	121090	0	0.59	0.009	GP (contact)
pe2r4_human	135	4.41x41	TM4	L => W	missense	1.653e-05	2	120994	0	0.01	0.222
pe2r4_human	143	4.49x49	TM4	V => A	missense	1.655e-05	2	120840	0	0.03	0.217
pe2r4_human	144	4.50x50	TM4	Y => C	missense	1.655e-05	2	120810	0	0.0	0.766
pe2r4_human	147	4.53x53	TM4	N => S	missense	2.484e-05	3	120758	0	0.02	0.137
pe2r4_human	149	4.55x55	TM4	L => I	missense	8.285e-06	1	120696	0	0.06	0.021
pe2r4_human	156	4.62x62	TM4	M => L	missense	8.3e-06	1	120484	0	0.27	0.028
pe2r4_human	156	4.62x62	TM4	M => V	missense	8.3e-06	1	120484	0	0.14	0.173
pe2r4_human	180	5.35x35	TM5	A => T	missense	8.39e-06	1	119190	0	1.0	0.004
pe2r4_human	180	5.35x35	TM5	A => E	missense	8.393e-06	1	119150	0	0.17	0.125
pe2r4_human	186	5.41x41	TM5	Y => C	missense	8.433e-06	1	118582	0	0.0	0.984
pe2r4_human	187	5.42x42	TM5	M => T	missense	1.689e-05	2	118446	0	0.13	0.115
pe2r4_human	193	5.48x48	TM5	S => C	missense	2.567e-05	3	116878	0	0.04	0.976
pe2r4_human	194	5.49x49	TM5	F => L	missense	8.584e-06	1	116496	0	1.0	0.01
pe2r4_human	196	5.51x51	TM5	I => V	missense	8.642e-06	1	115720	0	0.27	0.326
pe2r4_human	199	5.54x54	TM5	T => S	missense	8.782e-06	1	113874	0	0.0	0.857
pe2r4_human	205	5.60x60	TM5	L => R	missense	9.311e-06	1	107404	0	0.01	0.309
pe2r4_human	208	5.63x63	TM5	G => A	missense	9.759e-06	1	102468	0	0.64	0.009
pe2r4_human	212	5.67x67	TM5	R => H	missense	5.357e-05	5	93340	0	0.02	0.435	GP (contact)
pe2r4_human	215	5.70x70	TM5	R => C	missense	1.117e-05	1	89548	0	0.0	0.973
pe2r4_human	216	5.71x71	TM5	Q => R	missense	1.154e-05	1	86662	0	1.0	0.007	GP (contact)
pe2r4_human	224		ICL3	G => A	missense	1.557e-05	1	64216	0	0.08	0.241
pe2r4_human	225		ICL3	T => N	missense	3.114e-05	2	64222	0	0.05	0.014
pe2r4_human	229		ICL3	H => Q	missense	1.96e-05	1	51022	0	0.23	0.023
pe2r4_human	230		ICL3	A => E	missense	1.926e-05	1	51920	0	0.53	0.206
pe2r4_human	230		ICL3	A => V	missense	1.926e-05	1	51920	0	0.36	0.021
pe2r4_human	238		ICL3	S => T	missense	1.687e-05	1	59284	0	0.42	0.001
pe2r4_human	243		ICL3	A => T	missense	4.46e-05	3	67258	0	0.53	0.001
pe2r4_human	247		ICL3	A => G	missense	2.521e-05	2	79330	0	nan	0.004
pe2r4_human	249		ICL3	P => Q	missense	6.992e-05	6	85818	0	0.25	0.013
pe2r4_human	249		ICL3	P => R	missense	1.165e-05	1	85818	0	0.1	0.039
pe2r4_human	253		ICL3	D => G	missense	1.031e-05	1	96982	0	0.09	0.446
pe2r4_human	258		ICL3	R => G	missense	9.574e-06	1	104446	0	0.01	0.899
pe2r4_human	258		ICL3	R => P	missense	9.496e-06	1	105312	0	0.04	0.249
pe2r4_human	265	6.28x28	TM6	G => V	missense	1.84e-05	2	108692	0	0.0	0.616	GP (contact)
pe2r4_human	272	6.35x35	TM6	I => F	missense	1.836e-05	2	108944	0	0.08	0.111
pe2r4_human	289	6.52x52	TM6	V => M	missense	1.88e-05	2	106408	0	0.0	0.2
pe2r4_human	294	6.57x57	TM6	V => I	missense	0.01695	2017	118990	17	0.4	0.002
pe2r4_human	300		ECL3	P => S	missense	4.973e-05	6	120658	0	0.19	0.026
pe2r4_human	301		ECL3	S => R	missense	8.278e-06	1	120798	0	0.36	0.005
pe2r4_human	304		ECL3	R => Q	missense	9.08e-05	11	121142	0	0.57	0.009
pe2r4_human	313	7.37x36	TM7	Q => K	missense	0.001187	144	121360	0	1.0	0.036
pe2r4_human	335	8.49x49	H8	T => A	missense	8.239e-06	1	121372	0	0.32	0.003	PTM (Phosphorylation) GP (contact)
pe2r4_human	335	8.49x49	H8	T => R	missense	1.648e-05	2	121374	0	0.0	0.197	PTM (Phosphorylation) GP (contact)
pe2r4_human	341	8.55x55	H8	I => V	missense	8.239e-06	1	121370	0	0.37	0.003
pe2r4_human	345	8.59x59	H8	K => N	missense	8.24e-06	1	121354	0	0.01	0.762
pe2r4_human	346	8.60x60	H8	C => S	missense	8.241e-06	1	121346	0	0.14	0.392
pe2r4_human	348		C-term	F => S	missense	1.648e-05	2	121328	0	0.0	0.933
pe2r4_human	350		C-term	R => H	missense	3.312e-05	4	120756	0	0.0	0.696
pe2r4_human	351		C-term	I => T	missense	8.282e-06	1	120742	0	0.14	0.313
pe2r4_human	355		C-term	R => C	missense	0.0001986	24	120830	0	0.01	0.556
pe2r4_human	355		C-term	R => H	missense	6.619e-05	8	120868	0	0.14	0.005
pe2r4_human	356		C-term	R => G	missense	8.271e-06	1	120904	0	0.18	0.002
pe2r4_human	357		C-term	E => D	missense	3.307e-05	4	120958	0	0.8	0.001
pe2r4_human	358		C-term	R => C	missense	0.0002397	29	120960	0	0.07	0.368
pe2r4_human	358		C-term	R => H	missense	1.653e-05	2	120966	0	0.33	0.001
pe2r4_human	360		C-term	G => R	missense	1.652e-05	2	121064	0	0.09	0.003
pe2r4_human	362		C-term	H => R	missense	8.255e-06	1	121144	0	0.33	0.002
pe2r4_human	382		C-term	S => C	missense	4.948e-05	6	121258	0	0.0	0.728	PTM (Phosphorylation)
pe2r4_human	383		C-term	R => W	missense	8.248e-06	1	121246	0	0.04	0.01
pe2r4_human	383		C-term	R => Q	missense	4.949e-05	6	121242	0	0.11	0.347
pe2r4_human	386		C-term	K => R	missense	8.247e-06	1	121262	0	1.0	0.001
pe2r4_human	386		C-term	K => N	missense	8.246e-06	1	121268	0	0.01	0.138
pe2r4_human	391		C-term	T => I	missense	8.245e-06	1	121280	0	0.03	0.614
pe2r4_human	395		C-term	L => F	missense	8.245e-06	1	121284	0	0.5	0.015
pe2r4_human	401		C-term	L => Q	missense	8.246e-06	1	121278	0	0.05	0.079
pe2r4_human	403		C-term	D => N	missense	1.649e-05	2	121284	0	0.11	0.047
pe2r4_human	407		C-term	N => S	missense	8.245e-06	1	121290	0	0.8	0.0
pe2r4_human	409		C-term	L => P	missense	8.245e-06	1	121290	0	0.09	0.248
pe2r4_human	413		C-term	N => D	missense	8.245e-06	1	121292	0	0.41	0.021
pe2r4_human	417		C-term	G => R	missense	8.245e-06	1	121288	0	nan	0.927
pe2r4_human	418		C-term	V => M	missense	8.245e-06	1	121280	0	nan	0.332
pe2r4_human	420		C-term	G => D	missense	0.0001319	16	121286	0	nan	0.003
pe2r4_human	423		C-term	L => Q	missense	8.246e-06	1	121276	0	nan	0.01
pe2r4_human	425		C-term	Q => R	missense	8.247e-06	1	121260	0	nan	0.031
pe2r4_human	426		C-term	E => D	missense	8.248e-06	1	121244	0	nan	0.008
pe2r4_human	427		C-term	D => H	missense	2.474e-05	3	121240	0	nan	0.503
pe2r4_human	428		C-term	T => P	missense	6.599e-05	8	121234	0	nan	0.265
pe2r4_human	430		C-term	S => L	missense	5.775e-05	7	121208	0	nan	0.002	PTM (Phosphorylation)
pe2r4_human	434		C-term	L => W	missense	8.254e-06	1	121158	0	nan	0.002
pe2r4_human	434		C-term	L => S	missense	8.254e-06	1	121158	0	nan	0.135
pe2r4_human	435		C-term	R => Q	missense	0.0001238	15	121116	0	nan	0.033
pe2r4_human	441		C-term	D => V	missense	8.26e-06	1	121060	0	nan	0.007
pe2r4_human	444		C-term	Q => E	missense	8.263e-06	1	121018	0	nan	0.012
pe2r4_human	446		C-term	Q => R	missense	7.439e-05	9	120990	0	nan	0.021
pe2r4_human	447		C-term	D => Y	missense	4.132e-05	5	121002	0	nan	0.804
pe2r4_human	455		C-term	D => G	missense	8.273e-06	1	120876	0	nan	0.114
pe2r4_human	459		C-term	G => E	missense	8.516e-06	1	117430	0	nan	0.007
pe2r4_human	461		C-term	G => S	missense	6.782e-05	8	117968	0	1.0	0.001
pe2r4_human	467		C-term	P => L	missense	8.39e-06	1	119190	0	nan	0.034
pe2r4_human	472		C-term	L => V	missense	8.41e-06	1	118904	0	nan	0.718
pe2r4_human	473		C-term	Q => K	missense	8.418e-06	1	118798	0	nan	0.03
pe2r4_human	475		C-term	T => A	missense	8.449e-06	1	118362	0	nan	0.02
pe2r4_human	476		C-term	F => V	missense	8.472e-06	1	118040	0	nan	0.78
pe2r4_human	483		C-term	L => S	missense	2.616e-05	3	114682	0	nan	0.005
pe2r4_human	488		C-term	I => M	missense	2.675e-05	3	112156	0	nan	0.996

Residue

deleterious missense variants are shown in red
tolerated missense variants are shown in green
loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue

Diagrams

SnakePlot Download: PNG | SVG
HelixBox Download: PNG | SVG

Versions

Package	Name	Version
Django		2.2.1
Python		3.6.7
debug_toolbar	Debug Toolbar	1.11
polymorphic	Polymorphic	2.0.3
rest_framework	Django REST framework	3.9.3
rest_framework_swagger	Rest_Framework_Swagger	2.2.0

Time

Resource usage

Resource	Value
User CPU time	268.563 msec
System CPU time	4.178 msec
Total CPU time	272.741 msec
Elapsed time	284.649 msec
Context switches	10 voluntary, 1 involuntary

Browser timing

Timing attribute	Timeline	Milliseconds since navigation start (+length)

Settings from `protwis.settings`

Setting	Value
ABSOLUTE_URL_OVERRIDES	`{}`
ADMINS	`[]`
ALLOWED_HOSTS	`['*']`
APPEND_SLASH	`True`
AUTHENTICATION_BACKENDS	`['django.contrib.auth.backends.ModelBackend']`
AUTH_PASSWORD_VALIDATORS	`'********************'`
AUTH_USER_MODEL	`'auth.User'`
BASE_DIR	`'/home/protwis/gpcrdb_test'`
BUILD_CACHE_DIR	`'/home/protwis/gpcrdb_data/cache'`
CACHES	`{'alignments': {'BACKEND': 'django.core.cache.backends.filebased.FileBasedCache', 'LOCATION': '/home/protwis/caches/test_alignment', 'OPTIONS': {'MAX_ENTRIES': 1000}}, 'default': {'BACKEND': 'django.core.cache.backends.filebased.FileBasedCache', 'LOCATION': '/home/protwis/caches/test/', 'OPTIONS': {'MAX_ENTRIES': 10000000}}}`
CACHE_MIDDLEWARE_ALIAS	`'default'`
CACHE_MIDDLEWARE_KEY_PREFIX	`'********************'`
CACHE_MIDDLEWARE_SECONDS	`600`
CSRF_COOKIE_AGE	`31449600`
CSRF_COOKIE_DOMAIN	`None`
CSRF_COOKIE_HTTPONLY	`False`
CSRF_COOKIE_NAME	`'csrftoken'`
CSRF_COOKIE_PATH	`'/'`
CSRF_COOKIE_SAMESITE	`'Lax'`
CSRF_COOKIE_SECURE	`False`
CSRF_FAILURE_VIEW	`'django.views.csrf.csrf_failure'`
CSRF_HEADER_NAME	`'HTTP_X_CSRFTOKEN'`
CSRF_TRUSTED_ORIGINS	`[]`
CSRF_USE_SESSIONS	`False`
DATABASES	`{'default': {'ATOMIC_REQUESTS': False, 'AUTOCOMMIT': True, 'CONN_MAX_AGE': 0, 'ENGINE': 'django.db.backends.postgresql_psycopg2', 'HOST': 'localhost', 'NAME': 'protwis_202107', 'OPTIONS': {}, 'PASSWORD': '********************', 'PORT': '', 'TEST': {'CHARSET': None, 'COLLATION': None, 'MIRROR': None, 'NAME': None}, 'TIME_ZONE': None, 'USER': 'protwis'}}`
DATABASE_ROUTERS	`[]`
DATA_DIR	`'/home/protwis/gpcrdb_data'`
DATA_UPLOAD_MAX_MEMORY_SIZE	`2621440`
DATA_UPLOAD_MAX_NUMBER_FIELDS	`1000`
DATETIME_FORMAT	`'N j, Y, P'`
DATETIME_INPUT_FORMATS	`['%Y-%m-%d %H:%M:%S', '%Y-%m-%d %H:%M:%S.%f', '%Y-%m-%d %H:%M', '%Y-%m-%d', '%m/%d/%Y %H:%M:%S', '%m/%d/%Y %H:%M:%S.%f', '%m/%d/%Y %H:%M', '%m/%d/%Y', '%m/%d/%y %H:%M:%S', '%m/%d/%y %H:%M:%S.%f', '%m/%d/%y %H:%M', '%m/%d/%y']`
DATE_FORMAT	`'N j, Y'`
DATE_INPUT_FORMATS	`['%Y-%m-%d', '%m/%d/%Y', '%m/%d/%y', '%b %d %Y', '%b %d, %Y', '%d %b %Y', '%d %b, %Y', '%B %d %Y', '%B %d, %Y', '%d %B %Y', '%d %B, %Y']`
DEBUG	`True`
DEBUG_PROPAGATE_EXCEPTIONS	`False`
DEBUG_TOOLBAR_PATCH_SETTINGS	`False`
DECIMAL_SEPARATOR	`'.'`
DEFAULT_CHARSET	`'utf-8'`
DEFAULT_CONTENT_TYPE	`'text/html'`
DEFAULT_EXCEPTION_REPORTER_FILTER	`'django.views.debug.SafeExceptionReporterFilter'`
DEFAULT_FILE_STORAGE	`'django.core.files.storage.FileSystemStorage'`
DEFAULT_FROM_EMAIL	`'webmaster@localhost'`
DEFAULT_INDEX_TABLESPACE	`''`
DEFAULT_NUMBERING_SCHEME	`'gpcrdb'`
DEFAULT_PROTEIN_STATE	`'inactive'`
DEFAULT_SITE	`'gpcr'`
DEFAULT_TABLESPACE	`''`
DISALLOWED_USER_AGENTS	`[]`
DOCUMENTATION_URL	`'https://docs.gpcrdb.org/'`
EMAIL_BACKEND	`'django.core.mail.backends.smtp.EmailBackend'`
EMAIL_HOST	`'localhost'`
EMAIL_HOST_PASSWORD	`'********************'`
EMAIL_HOST_USER	`''`
EMAIL_PORT	`25`
EMAIL_SSL_CERTFILE	`None`
EMAIL_SSL_KEYFILE	`'********************'`
EMAIL_SUBJECT_PREFIX	`'[Django] '`
EMAIL_TIMEOUT	`None`
EMAIL_USE_LOCALTIME	`False`
EMAIL_USE_SSL	`False`
EMAIL_USE_TLS	`False`
FILE_CHARSET	`'utf-8'`
FILE_UPLOAD_DIRECTORY_PERMISSIONS	`None`
FILE_UPLOAD_HANDLERS	`['django.core.files.uploadhandler.MemoryFileUploadHandler', 'django.core.files.uploadhandler.TemporaryFileUploadHandler']`
FILE_UPLOAD_MAX_MEMORY_SIZE	`2621440`
FILE_UPLOAD_PERMISSIONS	`None`
FILE_UPLOAD_TEMP_DIR	`None`
FIRST_DAY_OF_WEEK	`0`
FIXTURE_DIRS	`[]`
FORCE_SCRIPT_NAME	`None`
FORMAT_MODULE_PATH	`None`
FORM_RENDERER	`'django.forms.renderers.DjangoTemplates'`
GOOGLE_ANALYTICS_API	`'********************'`
GOOGLE_ANALYTICS_KEY	`'********************'`
IGNORABLE_404_URLS	`[]`
INSTALLED_APPS	('django.contrib.admin', 'django.contrib.auth', 'django.contrib.contenttypes', 'django.contrib.sessions', 'django.contrib.messages', 'django.contrib.staticfiles', 'django.contrib.humanize', 'debug_toolbar', 'rest_framework', 'rest_framework_swagger', 'polymorphic', 'common', 'api', 'news', 'pages', 'home', 'protein', 'family', 'residue', 'alignment', 'similaritysearch', 'similaritymatrix', 'structure', 'ligand', 'interaction', 'mutation', 'phylogenetic_trees', 'sitesearch', 'build_gpcr', 'construct', 'tools', 'drugs', 'signprot', 'signprot2', 'mutational_landscape', 'contactnetwork', 'seqsign', 'angles', 'hotspots')
INTERNAL_IPS	`'10.0.2.2'`
LANGUAGES	[('af', 'Afrikaans'), ('ar', 'Arabic'), ('ast', 'Asturian'), ('az', 'Azerbaijani'), ('bg', 'Bulgarian'), ('be', 'Belarusian'), ('bn', 'Bengali'), ('br', 'Breton'), ('bs', 'Bosnian'), ('ca', 'Catalan'), ('cs', 'Czech'), ('cy', 'Welsh'), ('da', 'Danish'), ('de', 'German'), ('dsb', 'Lower Sorbian'), ('el', 'Greek'), ('en', 'English'), ('en-au', 'Australian English'), ('en-gb', 'British English'), ('eo', 'Esperanto'), ('es', 'Spanish'), ('es-ar', 'Argentinian Spanish'), ('es-co', 'Colombian Spanish'), ('es-mx', 'Mexican Spanish'), ('es-ni', 'Nicaraguan Spanish'), ('es-ve', 'Venezuelan Spanish'), ('et', 'Estonian'), ('eu', 'Basque'), ('fa', 'Persian'), ('fi', 'Finnish'), ('fr', 'French'), ('fy', 'Frisian'), ('ga', 'Irish'), ('gd', 'Scottish Gaelic'), ('gl', 'Galician'), ('he', 'Hebrew'), ('hi', 'Hindi'), ('hr', 'Croatian'), ('hsb', 'Upper Sorbian'), ('hu', 'Hungarian'), ('hy', 'Armenian'), ('ia', 'Interlingua'), ('id', 'Indonesian'), ('io', 'Ido'), ('is', 'Icelandic'), ('it', 'Italian'), ('ja', 'Japanese'), ('ka', 'Georgian'), ('kab', 'Kabyle'), ('kk', 'Kazakh'), ('km', 'Khmer'), ('kn', 'Kannada'), ('ko', 'Korean'), ('lb', 'Luxembourgish'), ('lt', 'Lithuanian'), ('lv', 'Latvian'), ('mk', 'Macedonian'), ('ml', 'Malayalam'), ('mn', 'Mongolian'), ('mr', 'Marathi'), ('my', 'Burmese'), ('nb', 'Norwegian Bokmål'), ('ne', 'Nepali'), ('nl', 'Dutch'), ('nn', 'Norwegian Nynorsk'), ('os', 'Ossetic'), ('pa', 'Punjabi'), ('pl', 'Polish'), ('pt', 'Portuguese'), ('pt-br', 'Brazilian Portuguese'), ('ro', 'Romanian'), ('ru', 'Russian'), ('sk', 'Slovak'), ('sl', 'Slovenian'), ('sq', 'Albanian'), ('sr', 'Serbian'), ('sr-latn', 'Serbian Latin'), ('sv', 'Swedish'), ('sw', 'Swahili'), ('ta', 'Tamil'), ('te', 'Telugu'), ('th', 'Thai'), ('tr', 'Turkish'), ('tt', 'Tatar'), ('udm', 'Udmurt'), ('uk', 'Ukrainian'), ('ur', 'Urdu'), ('vi', 'Vietnamese'), ('zh-hans', 'Simplified Chinese'), ('zh-hant', 'Traditional Chinese')]
LANGUAGES_BIDI	`['he', 'ar', 'fa', 'ur']`
LANGUAGE_CODE	`'en-us'`
LANGUAGE_COOKIE_AGE	`None`
LANGUAGE_COOKIE_DOMAIN	`None`
LANGUAGE_COOKIE_NAME	`'django_language'`
LANGUAGE_COOKIE_PATH	`'/'`
LOCALE_PATHS	`[]`
LOGGING	{'disable_existing_loggers': False, 'formatters': {'verbose': {'datefmt': '%d/%b/%Y %H:%M:%S', 'format': '[%(asctime)s] %(levelname)s ' '[%(name)s:%(lineno)s] %(message)s'}, 'verbose_low': {'datefmt': '%d/%b/%Y %H:%M:%S', 'format': '[%(asctime)s] %(levelname)s ' '[%(name)s:%(lineno)s]'}}, 'handlers': {'build': {'class': 'logging.FileHandler', 'filename': 'logs/build.log', 'formatter': 'verbose', 'level': 'DEBUG'}, 'django': {'class': 'logging.FileHandler', 'filename': 'logs/django.log', 'formatter': 'verbose', 'level': 'WARNING'}, 'protwis': {'class': 'logging.FileHandler', 'filename': 'logs/protwis.log', 'formatter': 'verbose', 'level': 'DEBUG'}}, 'loggers': {'build': {'handlers': ['build'], 'level': 'DEBUG'}, 'django': {'handlers': ['django'], 'level': 'WARNING', 'propagate': True}, 'protwis': {'handlers': ['protwis'], 'level': 'DEBUG'}}, 'version': 1}
LOGGING_CONFIG	`'logging.config.dictConfig'`
LOGIN_REDIRECT_URL	`'/accounts/profile/'`
LOGIN_URL	`'/accounts/login/'`
LOGOUT_REDIRECT_URL	`None`
MANAGERS	`[]`
MEDIA_ROOT	`'/protwis/media/protwis'`
MEDIA_URL	`'/media/'`
MESSAGE_STORAGE	`'django.contrib.messages.storage.fallback.FallbackStorage'`
MIDDLEWARE	`('common.middleware.stats.StatsMiddleware', 'debug_toolbar.middleware.DebugToolbarMiddleware', 'django.contrib.sessions.middleware.SessionMiddleware', 'django.middleware.common.CommonMiddleware', 'django.middleware.csrf.CsrfViewMiddleware', 'django.contrib.auth.middleware.AuthenticationMiddleware', 'django.contrib.messages.middleware.MessageMiddleware', 'django.middleware.clickjacking.XFrameOptionsMiddleware')`
MIGRATION_MODULES	`{}`
MONTH_DAY_FORMAT	`'F j'`
NUMBER_GROUPING	`0`
PASSWORD_HASHERS	`'********************'`
PASSWORD_RESET_TIMEOUT_DAYS	`'********************'`
PREPEND_WWW	`False`
REFERENCE_POSITIONS	`{'D1S1': 'D1S1x50', 'D1S2': 'D1S2x50', 'D1T1': 'D1T1x50', 'D1e1': 'D1e1x50', 'ECL1': '23x50', 'ECL2': '45x50', 'H8': '8x50', 'ICL1': '12x50', 'ICL2': '34x50', 'TM1': '1x50', 'TM2': '2x50', 'TM3': '3x50', 'TM4': '4x50', 'TM5': '5x50', 'TM6': '6x50', 'TM7': '7x50'}`
ROOT_URLCONF	`'protwis.urls'`
SECRET_KEY	`'********************'`
SECURE_BROWSER_XSS_FILTER	`False`
SECURE_CONTENT_TYPE_NOSNIFF	`False`
SECURE_HSTS_INCLUDE_SUBDOMAINS	`False`
SECURE_HSTS_PRELOAD	`False`
SECURE_HSTS_SECONDS	`0`
SECURE_PROXY_SSL_HEADER	`None`
SECURE_REDIRECT_EXEMPT	`[]`
SECURE_SSL_HOST	`None`
SECURE_SSL_REDIRECT	`False`
SERVER_EMAIL	`'root@localhost'`
SESSION_CACHE_ALIAS	`'default'`
SESSION_COOKIE_AGE	`86400`
SESSION_COOKIE_DOMAIN	`None`
SESSION_COOKIE_HTTPONLY	`True`
SESSION_COOKIE_NAME	`'sessionid'`
SESSION_COOKIE_PATH	`'/'`
SESSION_COOKIE_SAMESITE	`'Lax'`
SESSION_COOKIE_SECURE	`False`
SESSION_ENGINE	`'django.contrib.sessions.backends.db'`
SESSION_EXPIRE_AT_BROWSER_CLOSE	`False`
SESSION_FILE_PATH	`None`
SESSION_SAVE_EVERY_REQUEST	`False`
SESSION_SERIALIZER	`'django.contrib.sessions.serializers.PickleSerializer'`
SETTINGS_MODULE	`'protwis.settings'`
SHORT_DATETIME_FORMAT	`'m/d/Y P'`
SHORT_DATE_FORMAT	`'m/d/Y'`
SIGNING_BACKEND	`'django.core.signing.TimestampSigner'`
SILENCED_SYSTEM_CHECKS	`[]`
SITE_NAME	`'gpcr'`
SITE_TITLE	`'GPCRdb'`
STATICFILES_DIRS	`('/home/protwis/gpcrdb_test/static',)`
STATICFILES_FINDERS	`['django.contrib.staticfiles.finders.FileSystemFinder', 'django.contrib.staticfiles.finders.AppDirectoriesFinder']`
STATICFILES_STORAGE	`'django.contrib.staticfiles.storage.StaticFilesStorage'`
STATIC_ROOT	`'/home/protwis/static_test/'`
STATIC_URL	`'/static/'`
SWAGGER_SETTINGS	`{'USE_SESSION_AUTH': False}`
TEMPLATES	[{'APP_DIRS': True, 'BACKEND': 'django.template.backends.django.DjangoTemplates', 'DIRS': [], 'OPTIONS': {'context_processors': ['django.contrib.auth.context_processors.auth', 'django.template.context_processors.debug', 'django.template.context_processors.i18n', 'django.template.context_processors.media', 'django.template.context_processors.static', 'django.template.context_processors.tz', 'django.contrib.messages.context_processors.messages', 'protwis.context_processors.current_site', 'protwis.context_processors.canonical_tag', 'protwis.context_processors.documentation_url', 'protwis.context_processors.google_analytics', 'protwis.context_processors.site_title'], 'debug': True}}]
TEST_NON_SERIALIZED_APPS	`[]`
TEST_RUNNER	`'django.test.runner.DiscoverRunner'`
THOUSAND_SEPARATOR	`','`
TIME_FORMAT	`'P'`
TIME_INPUT_FORMATS	`['%H:%M:%S', '%H:%M:%S.%f', '%H:%M']`
TIME_ZONE	`'Europe/Copenhagen'`
USE_I18N	`True`
USE_L10N	`True`
USE_THOUSAND_SEPARATOR	`False`
USE_TZ	`True`
USE_X_FORWARDED_HOST	`False`
USE_X_FORWARDED_PORT	`False`
WSGI_APPLICATION	`None`
X_FRAME_OPTIONS	`'SAMEORIGIN'`
YEAR_MONTH_FORMAT	`'F Y'`

Headers

Request headers

Key	Value
Accept	text/html,application/xhtml+xml,application/xml;q=0.9,/;q=0.8
Accept-Encoding	br,gzip
Accept-Language	en-US,en;q=0.5
Connection	close
Host	test.gpcrdb.org
User-Agent	CCBot/2.0 (https://commoncrawl.org/faq/)
X-Forwarded-For	3.236.207.90
X-Forwarded-Proto	https
X-Real-Ip	3.236.207.90

Response headers

Key	Value
Content-Length	550773
Content-Type	text/html; charset=utf-8
Vary	Cookie
X-Frame-Options	SAMEORIGIN

WSGI environ

Since the WSGI environ inherits the environment of the server, only a significant subset is shown below.

Key	Value
PATH_INFO	/mutational_landscape/protein/PE2R4_human/
QUERY_STRING
REMOTE_ADDR
REQUEST_METHOD	GET
SCRIPT_NAME
SERVER_NAME	test.gpcrdb.org
SERVER_PORT	443
SERVER_PROTOCOL	HTTP/1.0
SERVER_SOFTWARE	gunicorn/19.9.0

Request

View information

View function	Arguments	Keyword arguments	URL name
`mutational_landscape.views.render_variants`	`()`	`{'protein': 'PE2R4_human'}`	`render`

No cookies

No session data

No GET data

No POST data

SQL queries from 1 connection

default 4.43 ms (1 query )

	Query	Timeline	Time (ms)	Action
	+	SELECT ••• "protein"."id", "protein"."parent_id", "protein"."family_id", "protein"."species_id", "protein"."source_id", "protein"."residue_numbering_scheme_id", "protein"."sequence_type_id", "protein"."entry_name", "protein"."accession", "protein"."name", "protein"."sequence" FROM "protein" WHERE "protein"."entry_name" = 'pe2r4_human'	100.0%	4.43
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(89) proteins.append(Protein.objects.get(entry_name=protein.lower()))

Query

Timeline

Time (ms)

Action

SELECT ••• "protein"."id", "protein"."parent_id", "protein"."family_id", "protein"."species_id", "protein"."source_id", "protein"."residue_numbering_scheme_id", "protein"."sequence_type_id", "protein"."entry_name", "protein"."accession", "protein"."name", "protein"."sequence" FROM "protein" WHERE "protein"."entry_name" = 'pe2r4_human'

100.0%

4.43

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(89)
  proteins.append(Protein.objects.get(entry_name=protein.lower()))

Static files (590 found, 40 used)

Static file path

/home/protwis/gpcrdb_test/static

Static file apps

django.contrib.admin
debug_toolbar
rest_framework
rest_framework_swagger
polymorphic

Static files

bootstrap/css/bootstrap.min.css: /home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap.min.css
bootstrap/css/bootstrap-submenu.min.css: /home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap-submenu.min.css
home/css/jquery-ui.min.css: /home/protwis/gpcrdb_test/static/home/css/jquery-ui.min.css
home/css/jquery-ui.theme.min.css: /home/protwis/gpcrdb_test/static/home/css/jquery-ui.theme.min.css
home/css/bootstrap-treeview.min.css: /home/protwis/gpcrdb_test/static/home/css/bootstrap-treeview.min.css
home/css/style.css: /home/protwis/gpcrdb_test/static/home/css/style.css
flowplayer/flowplayer.css: /home/protwis/gpcrdb_test/static/flowplayer/flowplayer.css
home/css/cookieconsent.min.css: /home/protwis/gpcrdb_test/static/home/css/cookieconsent.min.css
home/css/jquery.dataTables.min.css: /home/protwis/gpcrdb_test/static/home/css/jquery.dataTables.min.css
home/css/structure_browser.css: /home/protwis/gpcrdb_test/static/home/css/structure_browser.css
home/css/residue_table.css: /home/protwis/gpcrdb_test/static/home/css/residue_table.css
home/css/alignment.css: /home/protwis/gpcrdb_test/static/home/css/alignment.css
: /home/protwis/gpcrdb_test/static
home/css/mainmenu.css: /home/protwis/gpcrdb_test/static/home/css/mainmenu.css
home/css/modal.css: /home/protwis/gpcrdb_test/static/home/css/modal.css
home/css/jquery.powertip.css: /home/protwis/gpcrdb_test/static/home/css/jquery.powertip.css
home/js/jquery-3.1.1.min.js: /home/protwis/gpcrdb_test/static/home/js/jquery-3.1.1.min.js
home/js/citation_tool.js: /home/protwis/gpcrdb_test/static/home/js/citation_tool.js
home/js/joinus_tool.js: /home/protwis/gpcrdb_test/static/home/js/joinus_tool.js
home/js/jquery-3.1.1.min.js: /home/protwis/gpcrdb_test/static/home/js/jquery-3.1.1.min.js
home/js/jquery-ui.min.js: /home/protwis/gpcrdb_test/static/home/js/jquery-ui.min.js
bootstrap/js/bootstrap.min.js: /home/protwis/gpcrdb_test/static/bootstrap/js/bootstrap.min.js
bootstrap/js/bootstrap-submenu.js: /home/protwis/gpcrdb_test/static/bootstrap/js/bootstrap-submenu.js
home/js/navbar-autocomplete.js: /home/protwis/gpcrdb_test/static/home/js/navbar-autocomplete.js
home/js/svg-pan-zoom.min.js: /home/protwis/gpcrdb_test/static/home/js/svg-pan-zoom.min.js
home/js/bootstrap-treeview.min.js: /home/protwis/gpcrdb_test/static/home/js/bootstrap-treeview.min.js
home/js/papaparse.min.js: /home/protwis/gpcrdb_test/static/home/js/papaparse.min.js
flowplayer/flowplayer.min.js: /home/protwis/gpcrdb_test/static/flowplayer/flowplayer.min.js
flowplayer/flowplayer.overlay.min.js: /home/protwis/gpcrdb_test/static/flowplayer/flowplayer.overlay.min.js
flowplayer/flowplayer.overlay.bootstrap.js: /home/protwis/gpcrdb_test/static/flowplayer/flowplayer.overlay.bootstrap.js
home/js/gpcrdb.js: /home/protwis/gpcrdb_test/static/home/js/gpcrdb.js
home/js/cookieconsent.min.js: /home/protwis/gpcrdb_test/static/home/js/cookieconsent.min.js
home/js/jquery.dataTables.min.js: /home/protwis/gpcrdb_test/static/home/js/jquery.dataTables.min.js
home/js/dataTables.tableTools.min.js: /home/protwis/gpcrdb_test/static/home/js/dataTables.tableTools.min.js
home/js/jquery.dataTables.columnFilter.js: /home/protwis/gpcrdb_test/static/home/js/jquery.dataTables.columnFilter.js
home/js/selection.js: /home/protwis/gpcrdb_test/static/home/js/selection.js
home/js/saveSvgAsPng.js: /home/protwis/gpcrdb_test/static/home/js/saveSvgAsPng.js
home/js/alignment.js: /home/protwis/gpcrdb_test/static/home/js/alignment.js
home/js/diagrams.js: /home/protwis/gpcrdb_test/static/home/js/diagrams.js
home/js/residuetable.js: /home/protwis/gpcrdb_test/static/home/js/residuetable.js

django.contrib.staticfiles.finders.FileSystemFinder (415 files)

Path	Location
visualization_scripts/maestro_label_generic_numbers.py	/home/protwis/gpcrdb_test/static/visualization_scripts/maestro_label_generic_numbers.py
visualization_scripts/pymol_view_generic_numbers.pml	/home/protwis/gpcrdb_test/static/visualization_scripts/pymol_view_generic_numbers.pml
bootstrap/js/npm.js	/home/protwis/gpcrdb_test/static/bootstrap/js/npm.js
bootstrap/js/bootstrap.js	/home/protwis/gpcrdb_test/static/bootstrap/js/bootstrap.js
bootstrap/js/bootstrap-submenu.js	/home/protwis/gpcrdb_test/static/bootstrap/js/bootstrap-submenu.js
bootstrap/js/bootstrap.min.js	/home/protwis/gpcrdb_test/static/bootstrap/js/bootstrap.min.js
bootstrap/fonts/glyphicons-halflings-regular.eot	/home/protwis/gpcrdb_test/static/bootstrap/fonts/glyphicons-halflings-regular.eot
bootstrap/fonts/glyphicons-halflings-regular.woff	/home/protwis/gpcrdb_test/static/bootstrap/fonts/glyphicons-halflings-regular.woff
bootstrap/fonts/glyphicons-halflings-regular.ttf	/home/protwis/gpcrdb_test/static/bootstrap/fonts/glyphicons-halflings-regular.ttf
bootstrap/fonts/glyphicons-halflings-regular.svg	/home/protwis/gpcrdb_test/static/bootstrap/fonts/glyphicons-halflings-regular.svg
bootstrap/fonts/glyphicons-halflings-regular.woff2	/home/protwis/gpcrdb_test/static/bootstrap/fonts/glyphicons-halflings-regular.woff2
bootstrap/css/bootstrap.css.map	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap.css.map
bootstrap/css/bootstrap-submenu.css	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap-submenu.css
bootstrap/css/bootstrap.css	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap.css
bootstrap/css/bootstrap-theme.css.map	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap-theme.css.map
bootstrap/css/bootstrap-theme.min.css.map	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap-theme.min.css.map
bootstrap/css/bootstrap-submenu.min.css	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap-submenu.min.css
bootstrap/css/bootstrap.min.css.map	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap.min.css.map
bootstrap/css/bootstrap-submenu.css.map	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap-submenu.css.map
bootstrap/css/bootstrap.min.css	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap.min.css
bootstrap/css/bootstrap-theme.css	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap-theme.css
bootstrap/css/bootstrap-theme.min.css	/home/protwis/gpcrdb_test/static/bootstrap/css/bootstrap-theme.min.css
blast/protwis_blastdb.psq	/home/protwis/gpcrdb_test/static/blast/protwis_blastdb.psq
blast/protwis_human_bundle_blastdb.pin	/home/protwis/gpcrdb_test/static/blast/protwis_human_bundle_blastdb.pin
blast/protwis_blastdb.pin	/home/protwis/gpcrdb_test/static/blast/protwis_blastdb.pin
blast/protwis_human_blastdb.phr	/home/protwis/gpcrdb_test/static/blast/protwis_human_blastdb.phr
blast/protwis_blastdb.psd	/home/protwis/gpcrdb_test/static/blast/protwis_blastdb.psd
blast/protwis_blastdb.phr	/home/protwis/gpcrdb_test/static/blast/protwis_blastdb.phr
blast/protwis_human_blastdb.psq	/home/protwis/gpcrdb_test/static/blast/protwis_human_blastdb.psq
blast/protwis_human_gpcr_blastdb.phr	/home/protwis/gpcrdb_test/static/blast/protwis_human_gpcr_blastdb.phr
blast/protwis_human_gpcr_blastdb.psq	/home/protwis/gpcrdb_test/static/blast/protwis_human_gpcr_blastdb.psq
blast/protwis_gpcr_blastdb.psd	/home/protwis/gpcrdb_test/static/blast/protwis_gpcr_blastdb.psd
blast/protwis_human_blastdb.pin	/home/protwis/gpcrdb_test/static/blast/protwis_human_blastdb.pin
blast/protwis_human_blastdb.psd	/home/protwis/gpcrdb_test/static/blast/protwis_human_blastdb.psd
blast/protwis_human_blastdb.pog	/home/protwis/gpcrdb_test/static/blast/protwis_human_blastdb.pog
blast/.gitignore	/home/protwis/gpcrdb_test/static/blast/.gitignore
blast/protwis_human_gpcr_blastdb.psd	/home/protwis/gpcrdb_test/static/blast/protwis_human_gpcr_blastdb.psd
blast/protwis_blastdb.pog	/home/protwis/gpcrdb_test/static/blast/protwis_blastdb.pog
blast/protwis_gpcr_blastdb.psq	/home/protwis/gpcrdb_test/static/blast/protwis_gpcr_blastdb.psq
blast/protwis_human_gpcr_blastdb.psi	/home/protwis/gpcrdb_test/static/blast/protwis_human_gpcr_blastdb.psi
blast/protwis_gpcr_blastdb.pin	/home/protwis/gpcrdb_test/static/blast/protwis_gpcr_blastdb.pin
blast/protwis_human_bundle_blastdb.pog	/home/protwis/gpcrdb_test/static/blast/protwis_human_bundle_blastdb.pog
blast/protwis_human_gpcr_blastdb.pog	/home/protwis/gpcrdb_test/static/blast/protwis_human_gpcr_blastdb.pog
blast/protwis_blastdb.psi	/home/protwis/gpcrdb_test/static/blast/protwis_blastdb.psi
blast/protwis_human_bundle_blastdb.psd	/home/protwis/gpcrdb_test/static/blast/protwis_human_bundle_blastdb.psd
blast/protwis_human_bundle_blastdb.psq	/home/protwis/gpcrdb_test/static/blast/protwis_human_bundle_blastdb.psq
blast/protwis_gpcr_blastdb.pog	/home/protwis/gpcrdb_test/static/blast/protwis_gpcr_blastdb.pog
blast/protwis_human_blastdb.psi	/home/protwis/gpcrdb_test/static/blast/protwis_human_blastdb.psi
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django.contrib.staticfiles.finders.AppDirectoriesFinder (175 files)

Templates (9 rendered)

Template paths

None

Templates

browser.html: /home/protwis/gpcrdb_test/mutational_landscape/templates/browser.html; Toggle context
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"deleterious", "#e30e0e", ""], "74": ["S", ' '8.254e-06, 1, 121148, 0, "missense", "deleterious", ' '"#e30e0e", ""], "79": ["R", 8.258e-06, 1, 121094, 0, ' '"missense", "deleterious", "#e30e0e", ""], "81": ["L", ' '8.259e-06, 1, 121078, 0, "missense", "tolerated", ' '"#70c070", ""], "96": ["S", 8.253e-06, 1, 121166, 0, ' '"missense", "tolerated", "#70c070", ""], "101": ["L", ' '8.253e-06, 1, 121172, 0, "missense", "deleterious", ' '"#e30e0e", ""], "109": ["F", 1.651e-05, 2, 121168, 0, ' '"missense", "deleterious", "#e30e0e", ""], "112": ' '["T", 8.254e-06, 1, 121160, 0, "missense", ' '"deleterious", "#e30e0e", ""], "126": ["L", 1.652e-05, ' '2, 121070, 0, "missense", "tolerated", "#70c070", "GP ' '(contact) "], "129": ["Q", 3.303e-05, 4, 121090, 0, ' '"missense", "tolerated", "#70c070", "GP (contact) "], ' '"135": ["W", 1.653e-05, 2, 120994, 0, "missense", ' '"deleterious", "#e30e0e", ""], "143": ["A", 1.655e-05, ' '2, 120840, 0, "missense", "deleterious", "#e30e0e", ' '""], "144": ["C", 1.655e-05, 2, 120810, 0, "missense", ' '"deleterious", "#e30e0e", ""], "147": ["S", 2.484e-05, ' '3, 120758, 0, "missense", "deleterious", "#e30e0e", ' '""], "149": ["I", 8.285e-06, 1, 120696, 0, "missense", ' '"tolerated", "#70c070", ""], "156": ["V", 8.3e-06, 1, ' '120484, 0, "missense", "deleterious", "#e30e0e", ""], ' '"180": ["E", 8.393e-06, 1, 119150, 0, "missense", ' '"deleterious", "#e30e0e", ""], "186": ["C", 8.433e-06, ' '1, 118582, 0, "missense", "deleterious", "#e30e0e", ' '""], "187": ["T", 1.689e-05, 2, 118446, 0, "missense", ' '"deleterious", "#e30e0e", ""], "193": ["C", 2.567e-05, ' '3, 116878, 0, "missense", "deleterious", "#e30e0e", ' '""], "194": ["L", 8.584e-06, 1, 116496, 0, "missense", ' '"tolerated", "#70c070", ""], "196": ["V", 8.642e-06, ' '1, 115720, 0, "missense", "deleterious", "#e30e0e", ' '""], "199": ["S", 8.782e-06, 1, 113874, 0, "missense", ' '"deleterious", "#e30e0e", ""], "205": ["R", 9.311e-06, ' '1, 107404, 0, "missense", "deleterious", "#e30e0e", ' '""], "208": ["A", 9.759e-06, 1, 102468, 0, "missense", ' '"tolerated", "#70c070", ""], "212": ["H", 5.357e-05, ' '5, 93340, 0, "missense", "deleterious", "#e30e0e", "GP ' '(contact) "], "215": ["C", 1.117e-05, 1, 89548, 0, ' '"missense", "deleterious", "#e30e0e", ""], "216": ' '["R", 1.154e-05, 1, 86662, 0, "missense", "tolerated", ' '"#70c070", "GP (contact) "], "224": ["A", 1.557e-05, ' '1, 64216, 0, "missense", "deleterious", "#e30e0e", ' '""], "225": ["N", 3.114e-05, 2, 64222, 0, "missense", ' '"deleterious", "#e30e0e", ""], "229": ["Q", 1.96e-05, ' '1, 51022, 0, "missense", "tolerated", "#70c070", ""], ' '"230": ["V", 1.926e-05, 1, 51920, 0, "missense", ' '"tolerated", "#70c070", ""], "238": ["T", 1.687e-05, ' '1, 59284, 0, "missense", "tolerated", "#70c070", ""], ' '"243": ["T", 4.46e-05, 3, 67258, 0, "missense", ' '"tolerated", "#70c070", ""], "247": ["G", 2.521e-05, ' '2, 79330, 0, "missense", "tolerated", "#70c070", ""], ' '"249": ["R", 1.165e-05, 1, 85818, 0, "missense", ' '"tolerated", "#70c070", ""], "253": ["G", 1.031e-05, ' '1, 96982, 0, "missense", "deleterious", "#e30e0e", ' '""], "258": ["P", 9.496e-06, 1, 105312, 0, "missense", ' '"deleterious", "#e30e0e", ""], "265": ["V", 1.84e-05, ' '2, 108692, 0, "missense", "deleterious", "#e30e0e", ' '"GP (contact) "], "272": ["F", 1.836e-05, 2, 108944, ' '0, "missense", "deleterious", "#e30e0e", ""], "289": ' '["M", 1.88e-05, 2, 106408, 0, "missense", ' '"deleterious", "#e30e0e", ""], "294": ["I", 0.01695, ' '2017, 118990, 17, "missense", "tolerated", "#70c070", ' '""], "300": ["S", 4.973e-05, 6, 120658, 0, "missense", ' '"tolerated", "#70c070", ""], "301": ["R", 8.278e-06, ' '1, 120798, 0, "missense", "tolerated", "#70c070", ""], ' '"304": ["Q", 9.08e-05, 11, 121142, 0, "missense", ' '"tolerated", "#70c070", ""], "313": ["K", 0.001187, ' '144, 121360, 0, "missense", "tolerated", "#70c070", ' '""], "335": ["R", 1.648e-05, 2, 121374, 0, "missense", ' '"deleterious", "#e30e0e", "PTM (Phosphorylation) GP ' '(contact) "], "341": ["V", 8.239e-06, 1, 121370, 0, ' '"missense", "tolerated", "#70c070", ""], "345": ["N", ' '8.24e-06, 1, 121354, 0, "missense", "deleterious", ' '"#e30e0e", ""], "346": ["S", 8.241e-06, 1, 121346, 0, ' '"missense", "deleterious", "#e30e0e", ""], "348": ' '["S", 1.648e-05, 2, 121328, 0, "missense", ' '"deleterious", "#e30e0e", ""], "350": ["H", 3.312e-05, ' '4, 120756, 0, "missense", "deleterious", "#e30e0e", ' '""], "351": ["T", 8.282e-06, 1, 120742, 0, "missense", ' '"deleterious", "#e30e0e", ""], "355": ["H", 6.619e-05, ' '8, 120868, 0, "missense", "tolerated", "#70c070", ""], ' '"356": ["G", 8.271e-06, 1, 120904, 0, "missense", ' '"tolerated", "#70c070", ""], "357": ["D", 3.307e-05, ' '4, 120958, 0, "missense", "tolerated", "#70c070", ""], ' '"358": ["H", 1.653e-05, 2, 120966, 0, "missense", ' '"tolerated", "#70c070", ""], "360": ["R", 1.652e-05, ' '2, 121064, 0, "missense", "tolerated", "#70c070", ""], ' '"362": ["R", 8.255e-06, 1, 121144, 0, "missense", ' '"tolerated", "#70c070", ""], "382": ["C", 4.948e-05, ' '6, 121258, 0, "missense", "deleterious", "#e30e0e", ' '"PTM (Phosphorylation) "], "383": ["Q", 4.949e-05, 6, ' '121242, 0, "missense", "deleterious", "#e30e0e", ""], ' '"386": ["N", 8.246e-06, 1, 121268, 0, "missense", ' '"deleterious", "#e30e0e", ""], "391": ["I", 8.245e-06, ' '1, 121280, 0, "missense", "deleterious", "#e30e0e", ' '""], "395": ["F", 8.245e-06, 1, 121284, 0, "missense", ' '"tolerated", "#70c070", ""], "401": ["Q", 8.246e-06, ' '1, 121278, 0, "missense", "deleterious", "#e30e0e", ' '""], "403": ["N", 1.649e-05, 2, 121284, 0, "missense", ' '"tolerated", "#70c070", ""], "407": ["S", 8.245e-06, ' '1, 121290, 0, "missense", "tolerated", "#70c070", ""], ' '"409": ["P", 8.245e-06, 1, 121290, 0, "missense", ' '"deleterious", "#e30e0e", ""], "413": ["D", 8.245e-06, ' '1, 121292, 0, "missense", "tolerated", "#70c070", ""], ' '"417": ["R", 8.245e-06, 1, 121288, 0, "missense", ' '"deleterious", "#e30e0e", ""], "418": ["M", 8.245e-06, ' '1, 121280, 0, "missense", "deleterious", "#e30e0e", ' '""], "420": ["D", 0.0001319, 16, 121286, 0, ' '"missense", "tolerated", "#70c070", ""], "423": ["Q", ' '8.246e-06, 1, 121276, 0, "missense", "tolerated", ' '"#70c070", ""], "425": ["R", 8.247e-06, 1, 121260, 0, ' '"missense", "tolerated", "#70c070", ""], "426": ["D", ' '8.248e-06, 1, 121244, 0, "missense", "tolerated", ' '"#70c070", ""], "427": ["H", 2.474e-05, 3, 121240, 0, ' '"missense", "deleterious", "#e30e0e", ""], "428": ' '["P", 6.599e-05, 8, 121234, 0, "missense", ' '"deleterious", "#e30e0e", ""], "430": ["L", 5.775e-05, ' '7, 121208, 0, "missense", "tolerated", "#70c070", "PTM ' '(Phosphorylation) "], "434": ["S", 8.254e-06, 1, ' '121158, 0, "missense", "deleterious", "#e30e0e", ""], ' '"435": ["Q", 0.0001238, 15, 121116, 0, "missense", ' '"tolerated", "#70c070", ""], "441": ["V", 8.26e-06, 1, ' '121060, 0, "missense", "tolerated", "#70c070", ""], ' '"444": ["E", 8.263e-06, 1, 121018, 0, "missense", ' '"tolerated", "#70c070", ""], "446": ["R", 7.439e-05, ' '9, 120990, 0, "missense", "tolerated", "#70c070", ""], ' '"447": ["Y", 4.132e-05, 5, 121002, 0, "missense", ' '"deleterious", "#e30e0e", ""], "455": ["G", 8.273e-06, ' '1, 120876, 0, "missense", "deleterious", "#e30e0e", ' '""], "459": ["E", 8.516e-06, 1, 117430, 0, "missense", ' '"tolerated", "#70c070", ""], "461": ["S", 6.782e-05, ' '8, 117968, 0, "missense", "tolerated", "#70c070", ""], ' '"467": ["L", 8.39e-06, 1, 119190, 0, "missense", ' '"tolerated", "#70c070", ""], "472": ["V", 8.41e-06, 1, ' '118904, 0, "missense", "deleterious", "#e30e0e", ""], ' '"473": ["K", 8.418e-06, 1, 118798, 0, "missense", ' '"tolerated", "#70c070", ""], "475": ["A", 8.449e-06, ' '1, 118362, 0, "missense", "tolerated", "#70c070", ""], ' '"476": ["V", 8.472e-06, 1, 118040, 0, "missense", ' '"deleterious", "#e30e0e", ""], "483": ["S", 2.616e-05, ' '3, 114682, 0, "missense", "tolerated", "#70c070", ""], ' '"488": ["M", 2.675e-05, 3, 112156, 0, "missense", ' '"deleterious", "#e30e0e", ""]}', 'natural_mutations_pos_list': '{"26": {"val": 1, "AA": "L "}, "29": {"val": ' '2, "AA": "V L "}, "32": {"val": 1, "AA": "A ' '"}, "39": {"val": 1, "AA": "M "}, "74": ' '{"val": 1, "AA": "S "}, "79": {"val": 1, "AA": ' '"R "}, "81": {"val": 1, "AA": "L "}, "96": ' '{"val": 1, "AA": "S "}, "101": {"val": 1, ' '"AA": "L "}, "109": {"val": 1, "AA": "F "}, ' '"112": {"val": 1, "AA": "T "}, "126": {"val": ' '1, "AA": "L "}, "129": {"val": 1, "AA": "Q "}, ' '"135": {"val": 1, "AA": "W "}, "143": {"val": ' '1, "AA": "A "}, "144": {"val": 1, "AA": "C "}, ' '"147": {"val": 1, "AA": "S "}, "149": {"val": ' '1, "AA": "I "}, "156": {"val": 2, "AA": "L V ' '"}, "180": {"val": 2, "AA": "T E "}, "186": ' '{"val": 1, "AA": "C "}, "187": {"val": 1, ' '"AA": "T "}, "193": {"val": 1, "AA": "C "}, ' '"194": {"val": 1, "AA": "L "}, "196": {"val": ' '1, "AA": "V "}, "199": {"val": 1, "AA": "S "}, ' '"205": {"val": 1, "AA": "R "}, "208": {"val": ' '1, "AA": "A "}, "212": {"val": 1, "AA": "H "}, ' '"215": {"val": 1, "AA": "C "}, "216": {"val": ' '1, "AA": "R "}, "265": {"val": 1, "AA": "V "}, ' '"272": {"val": 1, "AA": "F "}, "289": {"val": ' '1, "AA": "M "}, "294": {"val": 1, "AA": "I "}, ' '"313": {"val": 1, "AA": "K "}, "335": {"val": ' '2, "AA": "A R "}, "341": {"val": 1, "AA": "V ' '"}, "345": {"val": 1, "AA": "N "}, "346": ' '{"val": 1, "AA": "S "}, "color": ["#c79494", ' '"#c40100"]}', 'receptor': 'pe2r4_human', 'type': 'protein'} {'hosts': {'arrestin': '', 'gpcr': '', 'gprotein': ''}}

Context processors

django.template.context_processors.csrf: Toggle context
{'csrf_token': <SimpleLazyObject: 'qbiKf5dVWFf70mWbDhWG0lCsnnHHeQDC8BQG2t4pghjOpuXp4sC3mWMLh8ZbV5CD'>}
django.contrib.auth.context_processors.auth: Toggle context
{'user': <SimpleLazyObject: <django.contrib.auth.models.AnonymousUser object at 0x7f2e73f4eac8>>, 'perms': <django.contrib.auth.context_processors.PermWrapper object at 0x7f2e714a8748>}
django.template.context_processors.debug: Toggle context
{'debug': True, 'sql_queries': <function debug.<locals>.<lambda> at 0x7f2e71da7950>}
django.template.context_processors.i18n: Toggle context
{'LANGUAGES': [('af', 'Afrikaans'), ('ar', 'Arabic'), ('ast', 'Asturian'), ('az', 'Azerbaijani'), ('bg', 'Bulgarian'), ('be', 'Belarusian'), ('bn', 'Bengali'), ('br', 'Breton'), ('bs', 'Bosnian'), ('ca', 'Catalan'), ('cs', 'Czech'), ('cy', 'Welsh'), ('da', 'Danish'), ('de', 'German'), ('dsb', 'Lower Sorbian'), ('el', 'Greek'), ('en', 'English'), ('en-au', 'Australian English'), ('en-gb', 'British English'), ('eo', 'Esperanto'), ('es', 'Spanish'), ('es-ar', 'Argentinian Spanish'), ('es-co', 'Colombian Spanish'), ('es-mx', 'Mexican Spanish'), ('es-ni', 'Nicaraguan Spanish'), ('es-ve', 'Venezuelan Spanish'), ('et', 'Estonian'), ('eu', 'Basque'), ('fa', 'Persian'), ('fi', 'Finnish'), ('fr', 'French'), ('fy', 'Frisian'), ('ga', 'Irish'), ('gd', 'Scottish Gaelic'), ('gl', 'Galician'), ('he', 'Hebrew'), ('hi', 'Hindi'), ('hr', 'Croatian'), ('hsb', 'Upper Sorbian'), ('hu', 'Hungarian'), ('hy', 'Armenian'), ('ia', 'Interlingua'), ('id', 'Indonesian'), ('io', 'Ido'), ('is', 'Icelandic'), ('it', 'Italian'), ('ja', 'Japanese'), ('ka', 'Georgian'), ('kab', 'Kabyle'), ('kk', 'Kazakh'), ('km', 'Khmer'), ('kn', 'Kannada'), ('ko', 'Korean'), ('lb', 'Luxembourgish'), ('lt', 'Lithuanian'), ('lv', 'Latvian'), ('mk', 'Macedonian'), ('ml', 'Malayalam'), ('mn', 'Mongolian'), ('mr', 'Marathi'), ('my', 'Burmese'), ('nb', 'Norwegian Bokmål'), ('ne', 'Nepali'), ('nl', 'Dutch'), ('nn', 'Norwegian Nynorsk'), ('os', 'Ossetic'), ('pa', 'Punjabi'), ('pl', 'Polish'), ('pt', 'Portuguese'), ('pt-br', 'Brazilian Portuguese'), ('ro', 'Romanian'), ('ru', 'Russian'), ('sk', 'Slovak'), ('sl', 'Slovenian'), ('sq', 'Albanian'), ('sr', 'Serbian'), ('sr-latn', 'Serbian Latin'), ('sv', 'Swedish'), ('sw', 'Swahili'), ('ta', 'Tamil'), ('te', 'Telugu'), ('th', 'Thai'), ('tr', 'Turkish'), ('tt', 'Tatar'), ('udm', 'Udmurt'), ('uk', 'Ukrainian'), ('ur', 'Urdu'), ('vi', 'Vietnamese'), ('zh-hans', 'Simplified Chinese'), ('zh-hant', 'Traditional Chinese')], 'LANGUAGE_CODE': 'en-us', 'LANGUAGE_BIDI': False}
django.template.context_processors.media: Toggle context
{'MEDIA_URL': '/media/'}
django.template.context_processors.static: Toggle context
{'STATIC_URL': '/static/'}
django.template.context_processors.tz: Toggle context
{'TIME_ZONE': 'Europe/Copenhagen'}
django.contrib.messages.context_processors.messages: Toggle context
{'messages': <django.contrib.messages.storage.fallback.FallbackStorage object at 0x7f2e5f278c88>, 'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30, 'ERROR': 40}}
protwis.context_processors.current_site: Toggle context
{'current_site': 'gpcr'}
protwis.context_processors.canonical_tag: Toggle context
{'canonical_tag': 'https://gpcrdb.org/mutational_landscape/protein/PE2R4_human/'}
protwis.context_processors.documentation_url: Toggle context
{'documentation_url': 'https://docs.gpcrdb.org/'}
protwis.context_processors.google_analytics: Toggle context
{}
protwis.context_processors.site_title: Toggle context
{'site_title': 'GPCRdb'}

Cache calls from 2 backends

Summary

Total calls	Total time	Cache hits	Cache misses
3	145.53451538085938 ms	2	0

Commands

add	get	set	delete	clear	get_many	set_many	delete_many	has_key	incr	decr	incr_version	decr_version
0	2	0	0	0	0	0	0	1	0	0	0	0

Calls

Time (ms)		Type	Arguments	Keyword arguments	Backend
+	1.7779	has_key	('VARIATION_eb6672df136ee694126e23664f2f8813',)	{}	<django.core.cache.backends.filebased.FileBasedCache object at 0x7f2e5f278898>
	/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(122) if not cache_variation.has_key(cache_key) and len(proteins)>0:
+	143.4772	get	('VARIATION_eb6672df136ee694126e23664f2f8813',)	{}	<django.core.cache.backends.filebased.FileBasedCache object at 0x7f2e5f278898>
	/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(252) cache_data = cache_variation.get(cache_key)
+	0.2794	get	('citation_urls',)	{}	<django.core.cache.backends.filebased.FileBasedCache object at 0x7f2e5f278898>
	/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(292) return render(request, 'browser.html', cache_data) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/shortcuts.py in render(36) content = loader.render_to_string(template_name, context, request, using=using) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/template/loader.py in render_to_string(62) return template.render(context, request) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/template/backends/django.py in render(61) return self.template.render(context) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/template/base.py in render(169) with context.bind_template(self): /usr/lib/python3.6/contextlib.py in __enter__(81) return next(self.gen) /home/protwis/gpcrdb_test/protwis/context_processors.py in canonical_tag(31) citation_dict = cache.get("citation_urls")

Signals

Signal	Providing	Receivers
class_prepared	class
connection_created	connection
got_request_exception	request
post_delete	instance, using
post_init	instance
post_migrate	app_config, plan, interactive, verbosity, apps, using	create_permissions, create_contenttypes
post_save	created, raw, instance, update_fields, using
pre_delete	instance, using
pre_init	instance, args, kwargs
pre_save	instance, using, update_fields, raw
request_finished		close_old_connections, close_caches, reset_urlconf
request_started	environ	reset_queries, close_old_connections

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