Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
tshr_human 8 N-term Q => HisfsTer55 frameshift 8.248e-06 1 121244 0 None None
tshr_human 31 N-term C => Ter stop gained 8.24e-06 1 121352 0 None None
tshr_human 42 N-term K => Ter stop gained 8.241e-06 1 121342 0 None None
tshr_human 57 N-term L => GlufsTer4 frameshift 8.252e-06 1 121178 0 None None
tshr_human 127 N-term L => SerfsTer2 frameshift 8.248e-06 1 121244 0 None None
tshr_human 153 N-term F => TyrfsTer10 frameshift 8.275e-06 1 120840 0 None None
tshr_human 178 N-term E => GlnfsTer2 frameshift 2.473e-05 3 121310 0 None None
tshr_human 223 N-term G => Ter stop gained 8.241e-06 1 121338 0 None None
tshr_human 244 N-term K => Ter stop gained 8.238e-06 1 121382 0 None None
tshr_human 294 N-term G => AsnfsTer3 frameshift 1.663e-05 2 120284 0 None None
tshr_human 374 N-term Q => ArgfsTer38 frameshift 8.237e-06 1 121410 0 None None
tshr_human 488 ECL1 W => Ter stop gained 8.239e-06 1 121380 0 None None
tshr_human 546 4.50x50 TM4 W => Ter stop gained 9.885e-05 12 121398 0 None None
tshr_human 601 5.58x58 TM5 Y => Ter stop gained 8.237e-06 1 121406 0 None None SodiumPocket MicroSwitch
tshr_human 609 5.66x66 TM5 R => Ter stop gained 8.237e-06 1 121410 0 None None GP (contact)
tshr_human 613 ICL3 Y => Ter stop gained 8.237e-06 1 121408 0 None None
tshr_human 643 6.54x54 TM6 Y => Ter frameshift 8.237e-06 1 121410 0 None None LB (polar (hydrogen bond), hydrophobic, Van der Waals)
tshr_human 655 ECL3 T => CysfsTer2 frameshift 2.471e-05 3 121412 0 None None
tshr_human 709 C-term Q => ArgfsTer20 frameshift 1.648e-05 2 121342 0 None None
tshr_human 2 N-term R => S missense 8.252e-06 1 121182 0 nan 0.981
tshr_human 10 N-term V => E missense 8.247e-06 1 121260 0 0.01 0.36
tshr_human 16 N-term P => T missense 1.649e-05 2 121296 0 0.03 0.272
tshr_human 18 N-term D => Y missense 8.243e-06 1 121316 0 0.01 0.229
tshr_human 22 N-term M => T missense 1.648e-05 2 121346 0 0.34 0.022
tshr_human 27 N-term P => L missense 8.24e-06 1 121356 0 0.07 0.059
tshr_human 29 N-term C => W missense 8.24e-06 1 121352 0 0.0 1.0
tshr_human 32 N-term H => Y missense 1.648e-05 2 121350 0 0.54 0.009
tshr_human 34 N-term E => K missense 0.0001895 23 121352 0 0.3 0.7
tshr_human 36 N-term D => H missense 0.006015 730 121356 5 0.14 0.117
tshr_human 40 N-term T => I missense 8.241e-06 1 121350 0 0.0 0.999
tshr_human 41 N-term C => S missense 4.12e-05 5 121346 0 0.0 1.0
tshr_human 42 N-term K => E missense 1.648e-05 2 121342 0 0.29 0.972
tshr_human 48 N-term P => S missense 8.244e-06 1 121298 0 0.0 0.999
tshr_human 49 N-term S => G missense 0.0001896 23 121288 0 0.29 0.39
tshr_human 51 N-term P => A missense 8.246e-06 1 121270 0 0.02 0.999
tshr_human 51 N-term P => L missense 1.65e-05 2 121248 0 0.01 1.0
tshr_human 52 N-term P => T missense 0.06959 8437 121244 519 0.18 0.311
tshr_human 52 N-term P => A missense 8.248e-06 1 121244 0 0.74 0.023
tshr_human 56 N-term T => I missense 8.253e-06 1 121168 0 0.08 0.844
tshr_human 57 N-term L => P missense 1.651e-05 2 121146 0 0.0 1.0
tshr_human 68 N-term P => S missense 0.0006469 78 120576 0 0.02 0.988
tshr_human 69 N-term S => T missense 8.293e-06 1 120578 0 0.09 0.857
tshr_human 77 N-term N => K missense 8.333e-06 1 120008 0 0.0 0.999 PTM (N-linked Glycosylation)
tshr_human 83 N-term V => I missense 5.774e-05 7 121226 0 1.0 0.002
tshr_human 90 N-term Q => P missense 8.244e-06 1 121298 0 0.0 0.966
tshr_human 90 N-term Q => H missense 8.244e-06 1 121302 0 0.02 0.983
tshr_human 92 N-term L => V missense 8.244e-06 1 121306 0 0.02 0.819
tshr_human 93 N-term E => G missense 8.243e-06 1 121310 0 0.0 0.933
tshr_human 101 N-term S => N missense 8.246e-06 1 121276 0 0.25 0.029
tshr_human 103 N-term V => L missense 6.598e-05 8 121254 0 0.32 0.006
tshr_human 105 N-term H => D missense 8.249e-06 1 121220 0 0.01 0.999
tshr_human 109 N-term R => W missense 8.248e-06 1 121246 0 0.0 1.0
tshr_human 109 N-term R => Q missense 1.649e-05 2 121252 0 0.36 1.0
tshr_human 117 N-term I => L missense 8.245e-06 1 121288 0 0.02 0.685
tshr_human 120 N-term D => N missense 8.245e-06 1 121290 0 0.12 0.04
tshr_human 121 N-term A => V missense 8.245e-06 1 121290 0 0.0 1.0
tshr_human 124 N-term E => D missense 4.948e-05 6 121252 0 0.11 0.001
tshr_human 132 N-term G => R missense 3.339e-05 4 119796 0 0.0 0.904
tshr_human 137 N-term G => V missense 1.662e-05 2 120366 0 0.0 1.0
tshr_human 143 N-term D => E missense 8.284e-06 1 120714 0 0.04 0.354
tshr_human 145 N-term T => I missense 4.14e-05 5 120772 0 0.0 0.946
tshr_human 155 N-term I => L missense 0.0007282 88 120840 0 0.24 0.064
tshr_human 155 N-term I => V missense 8.275e-06 1 120840 0 0.01 0.119
tshr_human 160 N-term D => E missense 8.244e-06 1 121306 0 0.13 0.114
tshr_human 162 N-term P => A missense 0.0001731 21 121310 0 0.25 0.441
tshr_human 162 N-term P => L missense 8.243e-06 1 121314 0 0.57 0.411
tshr_human 164 N-term M => L missense 8.243e-06 1 121318 0 0.16 0.056
tshr_human 165 N-term T => M missense 1.649e-05 2 121318 0 0.0 0.905
tshr_human 181 N-term T => S missense 8.245e-06 1 121292 0 0.04 0.32
tshr_human 200 N-term T => A missense 8.282e-06 1 120740 0 0.0 0.871
tshr_human 204 N-term A => V missense 1.659e-05 2 120554 0 0.02 0.95
tshr_human 214 N-term T => R missense 8.243e-06 1 121308 0 0.27 0.019
tshr_human 215 N-term V => A missense 2.473e-05 3 121318 0 0.56 0.002
tshr_human 216 N-term I => T missense 7.419e-05 9 121316 0 0.0 0.983
tshr_human 219 N-term D => N missense 8.242e-06 1 121330 0 0.13 0.07
tshr_human 220 N-term A => V missense 2.473e-05 3 121332 0 0.03 0.165
tshr_human 220 N-term A => E missense 8.242e-06 1 121332 0 0.0 0.848
tshr_human 225 N-term Y => H missense 8.241e-06 1 121338 0 0.4 0.004
tshr_human 228 N-term P => T missense 8.241e-06 1 121340 0 0.0 1.0
tshr_human 232 N-term D => H missense 8.238e-06 1 121382 0 0.0 0.998
tshr_human 233 N-term V => M missense 3.295e-05 4 121386 0 0.03 0.175
tshr_human 238 N-term V => D missense 8.238e-06 1 121388 0 0.0 0.739
tshr_human 240 N-term A => T missense 8.238e-06 1 121390 0 0.18 0.001
tshr_human 245 N-term G => S missense 0.00014 17 121388 0 0.0 0.862
tshr_human 245 N-term G => V missense 8.238e-06 1 121392 0 0.0 0.993
tshr_human 247 N-term E => Q missense 8.238e-06 1 121384 0 0.03 0.011
tshr_human 247 N-term E => K missense 8.238e-06 1 121384 0 0.07 0.032
tshr_human 247 N-term E => G missense 4.943e-05 6 121390 0 0.05 0.004
tshr_human 251 N-term E => Q missense 8.238e-06 1 121392 0 0.16 0.584
tshr_human 254 N-term A => V missense 8.239e-06 1 121380 0 0.03 0.026
tshr_human 266 N-term S => P missense 8.239e-06 1 121374 0 0.06 0.003
tshr_human 274 N-term R => W missense 1.648e-05 2 121364 0 0.0 0.949
tshr_human 274 N-term R => G missense 8.24e-06 1 121364 0 0.08 0.023
tshr_human 274 N-term R => L missense 8.24e-06 1 121360 0 0.05 0.235
tshr_human 275 N-term A => T missense 8.24e-06 1 121360 0 0.03 0.996
tshr_human 277 N-term L => I missense 8.241e-06 1 121338 0 0.0 0.96
tshr_human 279 N-term Y => D missense 8.242e-06 1 121336 0 0.0 0.994
tshr_human 282 N-term H => Q missense 8.246e-06 1 121272 0 0.0 0.983
tshr_human 290 N-term K => M missense 8.287e-06 1 120676 0 0.0 0.994
tshr_human 290 N-term K => N missense 1.657e-05 2 120676 0 0.02 0.984
tshr_human 291 N-term K => I missense 8.292e-06 1 120598 0 0.0 0.951
tshr_human 294 N-term G => E missense 1.67e-05 2 119782 0 0.14 0.987
tshr_human 298 N-term S => P missense 8.311e-06 1 120318 0 0.26 0.844 PTM (Phosphorylation)
tshr_human 301 N-term C => R missense 8.303e-06 1 120444 0 0.0 0.997
tshr_human 301 N-term C => Y missense 8.302e-06 1 120452 0 0.0 0.999
tshr_human 303 N-term E => V missense 1.659e-05 2 120536 0 0.3 0.096
tshr_human 303 N-term E => D missense 1.659e-05 2 120538 0 0.62 0.005
tshr_human 304 N-term S => N missense 8.295e-06 1 120558 0 0.02 0.772
tshr_human 305 N-term S => R missense 0.0002156 26 120606 0 0.4 0.008
tshr_human 307 N-term Q => K missense 8.286e-06 1 120680 0 0.36 0.005
tshr_human 310 N-term R => C missense 1.655e-05 2 120846 0 0.06 0.761
tshr_human 310 N-term R => H missense 0.0007032 85 120868 0 0.35 0.005
tshr_human 320 N-term S => N missense 8.248e-06 1 121244 0 0.48 0.003
tshr_human 323 N-term H => Y missense 8.243e-06 1 121314 0 1.0 0.0
tshr_human 326 N-term Y => D missense 8.24e-06 1 121364 0 0.14 0.017
tshr_human 328 N-term E => V missense 1.648e-05 2 121386 0 0.01 0.02
tshr_human 333 N-term S => G missense 1.647e-05 2 121398 0 0.17 0.0
tshr_human 334 N-term I => T missense 3.295e-05 4 121406 0 0.44 0.001
tshr_human 335 N-term V => I missense 8.237e-06 1 121410 0 0.24 0.062
tshr_human 338 N-term K => Q missense 8.237e-06 1 121410 0 0.61 0.015
tshr_human 340 N-term K => N missense 1.647e-05 2 121410 0 0.95 0.0
tshr_human 344 N-term Q => R missense 8.236e-06 1 121412 0 0.86 0.001
tshr_human 345 N-term D => N missense 8.236e-06 1 121412 0 0.21 0.025
tshr_human 346 N-term T => P missense 8.237e-06 1 121410 0 0.39 0.162
tshr_human 347 N-term H => R missense 1.647e-05 2 121412 0 0.32 0.005
tshr_human 350 N-term A => T missense 1.647e-05 2 121412 0 0.68 0.003
tshr_human 353 N-term Y => H missense 8.236e-06 1 121412 0 0.35 0.03
tshr_human 354 N-term V => I missense 1.647e-05 2 121412 0 0.3 0.019
tshr_human 360 N-term E => Q missense 8.237e-06 1 121410 0 0.11 0.513
tshr_human 364 N-term I => F missense 3.295e-05 4 121410 0 0.27 0.185
tshr_human 368 N-term Q => P missense 8.236e-06 1 121412 0 0.08 0.478
tshr_human 372 N-term N => T missense 7.413e-05 9 121410 0 0.14 0.249
tshr_human 372 N-term N => K missense 8.237e-06 1 121410 0 0.13 0.894
tshr_human 373 N-term P => R missense 3.295e-05 4 121410 0 0.01 0.867
tshr_human 375 N-term E => G missense 8.236e-06 1 121412 0 0.11 0.029
tshr_human 379 N-term Q => K missense 3.295e-05 4 121412 1 0.35 0.138
tshr_human 388 N-term T => I missense 8.236e-06 1 121412 0 0.42 0.007
tshr_human 389 N-term I => V missense 1.647e-05 2 121410 0 1.0 0.001
tshr_human 390 N-term C => F missense 1.647e-05 2 121410 0 0.0 1.0
tshr_human 390 N-term C => W missense 1.647e-05 2 121412 0 0.0 1.0
tshr_human 392 N-term D => N missense 4.118e-05 5 121410 0 0.15 0.138
tshr_human 393 N-term S => G missense 8.236e-06 1 121412 0 0.41 0.002
tshr_human 398 N-term C => G missense 5.765e-05 7 121412 0 0.0 1.0
tshr_human 399 N-term T => N missense 8.237e-06 1 121410 0 0.01 0.676
tshr_human 400 N-term P => R missense 8.236e-06 1 121412 0 0.0 1.0
tshr_human 403 N-term D => N missense 3.295e-05 4 121412 0 0.01 1.0
tshr_human 407 N-term P => L missense 2.471e-05 3 121412 0 0.0 1.0
tshr_human 407 N-term P => Q missense 8.236e-06 1 121412 0 0.0 1.0
tshr_human 408 N-term C => R missense 1.647e-05 2 121412 0 0.0 1.0
tshr_human 410 N-term D => N missense 8.236e-06 1 121412 0 0.0 0.996
tshr_human 415 1.33x33 TM1 K => R missense 8.236e-06 1 121412 0 0.25 0.005
tshr_human 419 1.37x37 TM1 I => T missense 8.236e-06 1 121412 0 0.0 0.46
tshr_human 421 1.39x39 TM1 V => M missense 8.237e-06 1 121410 0 0.04 1.0
tshr_human 422 1.40x40 TM1 W => R missense 1.647e-05 2 121412 0 0.0 1.0
tshr_human 424 1.42x42 TM1 V => F missense 1.647e-05 2 121412 0 0.0 1.0
tshr_human 424 1.42x42 TM1 V => I missense 8.236e-06 1 121412 0 0.98 0.999
tshr_human 424 1.42x42 TM1 V => A missense 8.236e-06 1 121412 0 0.0 0.999
tshr_human 432 1.50x50 TM1 N => S missense 2.471e-05 3 121412 0 0.0 0.999
tshr_human 440 1.58x58 TM1 L => I missense 8.237e-06 1 121400 0 0.31 0.54
tshr_human 444 ICL1 Y => H missense 5.765e-05 7 121412 0 0.0 1.0
tshr_human 447 ICL1 N => S missense 8.236e-06 1 121412 0 0.26 0.0
tshr_human 448 2.38x38 TM2 V => I missense 5.765e-05 7 121412 1 0.0 0.999
tshr_human 450 2.40x40 TM2 R => H missense 0.0002883 35 121412 0 0.0 1.0
tshr_human 452 2.42x42 TM2 L => P missense 8.236e-06 1 121412 0 0.0 1.0
tshr_human 454 2.44x44 TM2 C => S missense 8.236e-06 1 121412 0 0.0 0.999
tshr_human 457 2.47x47 TM2 A => V missense 8.236e-06 1 121412 0 0.0 0.999
tshr_human 459 2.49x49 TM2 A => V missense 1.647e-05 2 121412 0 0.0 0.999
tshr_human 470 2.60x60 TM2 I => T missense 8.237e-06 1 121404 0 0.0 1.0
tshr_human 475 2.65x65 TM2 L => F missense 1.647e-05 2 121400 0 0.25 0.238
tshr_human 487 ECL1 D => N missense 4.119e-05 5 121384 0 0.02 0.329
tshr_human 495 3.26x26 TM3 N => Y missense 8.24e-06 1 121358 0 0.01 0.891
tshr_human 495 3.26x26 TM3 N => S missense 4.944e-05 6 121350 1 0.56 0.03
tshr_human 496 3.27x27 TM3 T => K missense 8.241e-06 1 121340 0 0.04 0.389
tshr_human 500 3.31x31 TM3 F => V missense 8.242e-06 1 121334 0 0.02 0.797
tshr_human 504 3.35x35 TM3 A => S missense 8.244e-06 1 121302 0 0.06 0.684
tshr_human 506 3.37x37 TM3 E => K missense 8.244e-06 1 121294 0 0.0 0.999 LB (polar (charge-assisted hydrogen bond))
tshr_human 508 3.39x39 TM3 S => L missense 8.245e-06 1 121282 0 0.0 0.999
tshr_human 511 3.42x42 TM3 T => M missense 3.298e-05 4 121294 0 0.0 1.0
tshr_human 514 3.45x45 TM3 V => I missense 2.473e-05 3 121296 0 0.03 0.043
tshr_human 516 3.47x47 TM3 T => N missense 1.649e-05 2 121300 0 0.0 1.0
tshr_human 516 3.47x47 TM3 T => I missense 8.244e-06 1 121300 0 0.0 1.0
tshr_human 518 3.49x49 TM3 E => V missense 8.245e-06 1 121290 0 0.0 1.0 SodiumPocket MicroSwitch
tshr_human 519 3.50x50 TM3 R => C missense 4.123e-05 5 121272 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
tshr_human 519 3.50x50 TM3 R => H missense 1.649e-05 2 121274 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
tshr_human 520 3.51x51 TM3 W => S missense 8.245e-06 1 121280 0 0.0 1.0
tshr_human 520 3.51x51 TM3 W => C missense 8.244e-06 1 121294 0 0.0 1.0
tshr_human 522 3.53x53 TM3 A => T missense 2.473e-05 3 121302 0 1.0 0.983 GP (contact)
tshr_human 524 3.55x55 TM3 T => I missense 8.244e-06 1 121304 0 0.0 0.444 GP (contact)
tshr_human 525 3.56x56 TM3 F => S missense 0.0001319 16 121316 0 0.11 0.984 GP (contact)
tshr_human 526 34.50x50 ICL2 A => T missense 4.122e-05 5 121302 0 0.0 0.999 GP (contact)
tshr_human 527 34.51x51 ICL2 M => V missense 8.243e-06 1 121316 0 0.07 0.73 GP (contact)
tshr_human 528 34.52x52 ICL2 R => C missense 8.244e-06 1 121306 0 0.0 0.91 GP (contact)
tshr_human 528 34.52x52 ICL2 R => H missense 7.419e-05 9 121318 0 0.05 0.063 GP (contact)
tshr_human 531 34.55x55 ICL2 R => W missense 3.297e-05 4 121340 0 0.0 0.999 GP (contact)
tshr_human 531 34.55x55 ICL2 R => G missense 8.241e-06 1 121340 0 0.01 0.987 GP (contact)
tshr_human 531 34.55x55 ICL2 R => Q missense 8.243e-06 1 121322 0 0.2 0.969 GP (contact)
tshr_human 534 4.38x38 TM4 R => C missense 0.0005191 63 121360 0 0.03 0.099
tshr_human 534 4.38x38 TM4 R => S missense 8.24e-06 1 121360 0 0.0 0.785
tshr_human 534 4.38x38 TM4 R => H missense 0.0001071 13 121360 0 0.09 0.043
tshr_human 538 4.42x42 TM4 A => S missense 2.472e-05 3 121376 0 0.0 1.0
tshr_human 541 4.45x45 TM4 I => V missense 5.767e-05 7 121390 0 0.46 0.005
tshr_human 541 4.45x45 TM4 I => N missense 8.238e-06 1 121388 0 0.0 0.776
tshr_human 545 4.49x49 TM4 G => C missense 8.238e-06 1 121394 0 0.0 1.0
tshr_human 549 4.53x53 TM4 C => R missense 8.237e-06 1 121404 0 0.0 0.94
tshr_human 553 4.57x57 TM4 A => T missense 3.295e-05 4 121402 0 0.0 0.99
tshr_human 553 4.57x57 TM4 A => S missense 8.237e-06 1 121402 0 0.01 0.987
tshr_human 558 4.62x62 TM4 V => L missense 8.237e-06 1 121400 0 0.27 0.019
tshr_human 561 ECL2 S => N missense 8.237e-06 1 121402 0 0.02 0.97
tshr_human 566 ECL2 V => I missense 8.237e-06 1 121400 0 0.0 0.999
tshr_human 568 ECL2 I => N missense 4.942e-05 6 121398 0 0.0 1.0
tshr_human 574 ECL2 T => S missense 0.0005189 63 121402 1 0.01 0.951
tshr_human 575 ECL2 E => K missense 8.237e-06 1 121402 0 0.04 0.045
tshr_human 579 5.36x36 TM5 A => T missense 8.237e-06 1 121402 0 0.01 0.575
tshr_human 582 5.39x39 TM5 Y => F missense 1.647e-05 2 121404 0 0.0 0.999
tshr_human 586 5.43x43 TM5 V => A missense 8.237e-06 1 121406 0 0.0 0.96 LB (polar (hydrogen bond), Van der Waals)
tshr_human 588 5.45x45 TM5 T => M missense 1.647e-05 2 121406 0 0.19 0.0
tshr_human 591 5.48x48 TM5 I => V missense 8.237e-06 1 121406 0 1.0 0.044
tshr_human 595 5.52x52 TM5 V => I missense 0.0001894 23 121406 0 0.76 0.003
tshr_human 596 5.53x53 TM5 I => T missense 4.942e-05 6 121406 0 0.02 0.419
tshr_human 597 5.54x54 TM5 V => I missense 1.647e-05 2 121406 0 1.0 0.017
tshr_human 600 5.57x57 TM5 C => S missense 8.237e-06 1 121406 0 0.0 0.999
tshr_human 602 5.59x59 TM5 V => M missense 8.237e-06 1 121406 0 0.0 0.197
tshr_human 606 5.63x63 TM5 I => T missense 8.237e-06 1 121406 0 0.13 0.008
tshr_human 609 5.66x66 TM5 R => Q missense 7.413e-05 9 121408 0 0.29 0.951 GP (contact)
tshr_human 611 ICL3 P => L missense 8.237e-06 1 121408 0 0.0 1.0
tshr_human 613 ICL3 Y => C missense 2.471e-05 3 121408 0 0.02 0.994
tshr_human 617 6.28x28 TM6 D => E missense 8.236e-06 1 121412 0 0.04 0.007 GP (contact)
tshr_human 626 6.37x37 TM6 M => T missense 8.236e-06 1 121412 0 0.0 0.999 GP (contact)
tshr_human 635 6.46x46 TM6 I => L missense 8.236e-06 1 121412 0 1.0 0.001
tshr_human 635 6.46x46 TM6 I => M missense 2.471e-05 3 121410 0 0.21 0.007
tshr_human 637 6.48x48 TM6 M => T missense 8.236e-06 1 121412 0 0.01 0.979 SodiumPocket MicroSwitch
tshr_human 646 6.57x57 TM6 S => P missense 8.236e-06 1 121412 0 0.0 0.992
tshr_human 649 6.60x60 TM6 L => M missense 2.471e-05 3 121412 0 0.51 0.047
tshr_human 652 ECL3 P => S missense 8.236e-06 1 121412 0 0.0 1.0
tshr_human 654 ECL3 I => F missense 2.471e-05 3 121412 0 0.0 1.0
tshr_human 657 7.32x31 TM7 S => G missense 8.236e-06 1 121412 0 0.0 0.492
tshr_human 667 7.42x41 TM7 Y => H missense 8.236e-06 1 121412 0 0.01 1.0 LB (polar (hydrogen bond))
tshr_human 669 7.44x43 TM7 L => F missense 8.236e-06 1 121412 0 0.0 1.0 SodiumPocket MicroSwitch
tshr_human 676 7.51x51 TM7 F => L missense 8.236e-06 1 121412 0 0.0 0.999
tshr_human 678 7.53x53 TM7 Y => C missense 8.236e-06 1 121412 0 0.0 1.0 SodiumPocket MicroSwitch
tshr_human 679 7.54x54 TM7 A => V missense 8.236e-06 1 121412 0 0.01 0.997
tshr_human 680 7.55x55 TM7 I => V missense 8.236e-06 1 121412 0 0.06 0.071 GP (contact)
tshr_human 684 8.49x49 H8 A => D missense 8.237e-06 1 121410 0 0.02 0.206 GP (contact)
tshr_human 688 8.53x53 H8 D => E missense 8.237e-06 1 121410 0 0.0 1.0
tshr_human 689 8.54x54 H8 V => G missense 4.118e-05 5 121410 0 0.0 0.986
tshr_human 691 8.56x56 H8 I => L missense 8.237e-06 1 121410 0 0.3 0.169
tshr_human 694 8.59x59 H8 S => N missense 8.237e-06 1 121402 0 0.02 0.207
tshr_human 696 8.61x61 H8 F => I missense 8.237e-06 1 121404 0 0.06 0.037
tshr_human 696 8.61x61 H8 F => L missense 8.237e-06 1 121404 0 0.14 0.012
tshr_human 700 C-term K => E missense 0.0001071 13 121394 1 1.0 0.008
tshr_human 701 C-term R => C missense 9.062e-05 11 121386 0 0.08 0.828
tshr_human 701 C-term R => H missense 1.648e-05 2 121392 1 0.77 0.008
tshr_human 702 C-term Q => R missense 3.295e-05 4 121392 0 0.42 0.011
tshr_human 707 C-term R => W missense 1.648e-05 2 121342 0 0.0 0.98
tshr_human 707 C-term R => G missense 8.241e-06 1 121342 0 0.0 0.806
tshr_human 707 C-term R => Q missense 0.0001072 13 121320 0 0.03 0.082
tshr_human 716 C-term S => I missense 8.248e-06 1 121246 0 0.0 0.57
tshr_human 716 C-term S => N missense 8.248e-06 1 121246 0 0.09 0.046
tshr_human 721 C-term V => F missense 0.001081 131 121210 0 0.24 0.091
tshr_human 721 C-term V => I missense 8.25e-06 1 121210 0 0.32 0.001
tshr_human 724 C-term V => F missense 8.251e-06 1 121202 0 0.07 0.188
tshr_human 725 C-term T => I missense 2.476e-05 3 121178 0 0.17 0.005
tshr_human 728 C-term M => V missense 8.244e-06 1 121296 0 0.46 0.001
tshr_human 729 C-term R => W missense 8.244e-06 1 121298 0 0.02 0.649
tshr_human 731 C-term G => C missense 1.649e-05 2 121316 0 nan 0.556
tshr_human 731 C-term G => V missense 8.243e-06 1 121310 0 nan 0.005
tshr_human 735 C-term M => V missense 8.243e-06 1 121316 0 nan 0.001
tshr_human 742 C-term I => V missense 8.24e-06 1 121352 0 nan 0.012
tshr_human 742 C-term I => T missense 1.648e-05 2 121346 0 nan 0.088
tshr_human 744 C-term N => K missense 0.005002 607 121346 15 nan 0.004
tshr_human 745 C-term S => C missense 4.944e-05 6 121352 0 nan 0.698 PTM (Phosphorylation)
tshr_human 748 C-term T => I missense 8.24e-06 1 121358 0 nan 0.099 PTM (Phosphorylation)
tshr_human 751 C-term K => R missense 7.416e-05 9 121366 0 nan 0.004
tshr_human 752 C-term Q => K missense 8.24e-06 1 121362 0 nan 0.045
tshr_human 753 C-term G => S missense 8.239e-06 1 121370 0 nan 0.005
tshr_human 758 C-term E => K missense 4.121e-05 5 121344 0 nan 0.075
tshr_human 760 C-term M => T missense 2.473e-05 3 121304 0 nan 0.0
tshr_human 761 C-term Q => K missense 8.245e-06 1 121292 0 nan 0.045
tshr_human 762 C-term T => M missense 8.247e-06 1 121254 0 nan 0.79


Residue

Diagrams

ICL1 H Y K L N ICL1ECL1 H S E Y Y N H A I D W Q T ECL1ICL2 A M R L D R K I ICL2ECL2 I S S Y A K V S I C L P M D T E ECL2ICL3 P Q Y N ICL3ECL3 K P L I T ECL3N-term M R P A D L L Q L V L L L D L P R D L G G M G C S S P P C E C H Q E E D F R V T C K D I Q R I P S L P P S T Q T L K L I E T H L R T I P S H A F S N L P N I S R I Y V S I D V T L Q Q L E S H S F Y N L S K V T H I E I R N T R N L T Y I D P D A L K E L P L L K F L G I F N T G L K M F P D L T K V Y S T D I F F I L E I T D N P Y M T S I P V N A F Q G L C N E T L T L K L Y N N G F T S V Q G Y A F N G T K L D A V Y L N K N K Y L T V I D K D A F G G V Y S G P S L L D V S Q T S V T A L P S K G L E H L K E L I A R N T W T L K K L P L S L S F L H L T R A D L S Y P S H C C A F K N Q K K I R G I L E S L M C N E S S M Q S L R Q R K S V N A L N S P L H Q E Y E E N L G D S I V G Y K E K S K F Q D T H N N A H Y Y V F F E E Q E D E I I G F G Q E L K N P Q E E T L Q A F D S H Y D Y T I C G D S E D M V C T P K S D E F N P C E D I M G N-termC-term G I C K R Q A Q A Y R G Q R V P P K N S T D I Q V Q K V T H D M R Q G L H N M E D V Y E L I E N S H L T P K K Q G Q I S E E Y M Q T V L C-term Y K F L R I V V W F V S L L A L L G N V F V L L I L L T S V P R F L M C N L A F A D F C M G M Y L L L I A S V D L Y T G P G C N T A G F F T V F A S E L S V Y T L T V I T L E R W Y A I T F R L R H A C A I M V G G W V C C F L L A L L P L V G T P L A L A Y I V F V L T L N I V A F V I V C C C Y V K I Y I T V R N P G D K D T K I A K R M A V L I F T D F I C M A P I S F Y A L S A I L N V S N S K I L L V L F Y P L N S C A N P F L Y A I F T K A V F I F F Q R D L L S K
SnakePlot Download: PNG | SVG V N G L L A L L S V F W V V I R L F K Y 1 C N L A F A D F C M G M Y L L L I A S V 2 V T L T Y V S L E S A F V T F F G A T N 3 A C A I M V G G W V C C F L L A L L P L 4 Y C C C V I V F A V I N L T L V F V I Y 5 A V L I F T D F I C M A P I S F Y A L S 6 F P N A C S N L P Y F L V L L I K S N 7
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