Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

3RFM

SPECIES

Homo sapiens

RESOLUTION

3.600

PREFERRED CHAIN

A

REFERENCE

10.1016/J.STR.2011.06.014

PUBLICATION DATE

Sept. 7, 2011

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
caffeine F168 45.52x52 ECL2 hydrophobic
caffeine L249 6.51x51 TM6 hydrophobic
caffeine N253 6.55x55 TM6 polar (hydrogen bond)
caffeine N253 6.55x55 TM6 Van der Waals
caffeine M270 7.35x34 TM7 hydrophobic
caffeine M270 7.35x34 TM7 Van der Waals
caffeine I274 7.39x38 TM7 Van der Waals
caffeine I274 7.39x38 TM7 hydrophobic

Ligands

caffeine

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
ECL2
45x52 45.52x52 F168
TM6
6x51 6.51x51 L249
6x55 6.55x55 N253
TM7
7x34 7.35x34 M270
7x38 7.39x38 I274