Structure information

P2Y12 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

4PY0

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE13288

PUBLICATION DATE

April 30, 2014

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
2MeSATP R93 3.21x21 TM3 polar (charge-assisted hydrogen bond)
2MeSATP C97 3.25x25 TM3 Van der Waals
2MeSATP C97 3.25x25 TM3 polar (hydrogen bond with backbone)
2MeSATP S101 3.29x29 TM3 Van der Waals
2MeSATP V102 3.30x30 TM3 hydrophobic
2MeSATP V102 3.30x30 TM3 Van der Waals
2MeSATP Y105 3.33x33 TM3 polar (hydrogen bond)
2MeSATP Y105 3.33x33 TM3 aromatic (face-to-face)
2MeSATP Y105 3.33x33 TM3 Van der Waals
2MeSATP F106 3.34x34 TM3 Van der Waals
2MeSATP S156 4.57x57 TM4 polar (hydrogen bond)
2MeSATP N159 4.60x60 TM4 Van der Waals
2MeSATP N159 4.60x60 TM4 polar (hydrogen bond)
2MeSATP K173 ECL2 polar (hydrogen bond with backbone)
2MeSATP K173 ECL2 Van der Waals
2MeSATP K174 ECL2 Van der Waals
2MeSATP C175 45.50x50 ECL2 polar (hydrogen bond with backbone)
2MeSATP C175 45.50x50 ECL2 polar (hydrogen bond)
2MeSATP C175 45.50x50 ECL2 Van der Waals
2MeSATP S176 45.51x51 ECL2 polar (hydrogen bond with backbone)
2MeSATP S176 45.51x51 ECL2 Van der Waals
2MeSATP K179 ECL2 polar (charge-assisted hydrogen bond)
2MeSATP H187 5.36x36 TM5 Van der Waals
2MeSATP H187 5.36x36 TM5 aromatic (edge-to-face)
2MeSATP H187 5.36x36 TM5 polar (hydrogen bond)
2MeSATP V190 5.39x39 TM5 Van der Waals
2MeSATP V190 5.39x39 TM5 hydrophobic
2MeSATP N191 5.40x40 TM5 polar (hydrogen bond)
2MeSATP N191 5.40x40 TM5 polar (hydrogen bond)
2MeSATP C194 5.43x43 TM5 polar (hydrogen bond)
2MeSATP R256 6.55x55 TM6 polar (charge-assisted hydrogen bond)
2MeSATP Y259 6.58x58 TM6 polar (hydrogen bond)
2MeSATP Y259 6.58x58 TM6 polar (hydrogen bond)
2MeSATP Q263 6.62x62 TM6 polar (hydrogen bond)
2MeSATP Q263 6.62x62 TM6 Van der Waals
2MeSATP K280 7.35x34 TM7 polar (charge-assisted hydrogen bond)

Ligands

2MeSATP

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Residue Diagrams

G N T I L G V F F L V T Y L L P F L V Q 1 K N T V I S D L L M I L T F P F K I L S 2 L G L F S I S I Y M T F Y F I V S T V Q 3 A K I L S V V I W A F M F L L S L P N M 4 Y C V I V I L F N I W F I V Q C I Y N V 5 V F I I I A V F I F C F V P F H F A R I P 6 F P D L C A N L S T L W L T S E K V Y 7
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ICL1 R S K ICL1ECL1 L G T ECL1ICL2 P F K T S N P K ICL2ECL2 N R Q P R D K N V K K C S F L K S ECL2ICL3 R G V G K V ICL3ECL3 D V F ECL3N-term M Q A V D N L T S A P G N T S L C T R D N-termC-term L K C P N S A T S L S Q D N R K K E Q D G G D P N E E T P M C-term Y K I T Q V L F P L L Y T V L F F V G L I T N G L A M R I F F Q I S N F I I F L K N T V I S D L L M I L T F P F K I L S D A K G P L R T F V C Q V T S V I F Y F T M Y I S I S F L G L I T I D R Y Q K T T R N L L G A K I L S V V I W A F M F L L S L P N M I L T E F G L V W H E I V N Y I C Q V I F W I N F L I V I V C Y T L I T K E L Y R S Y V R T P R K K V N V K V F I I I A V F F I C F V P F H F A R I P Y T L S Q T R D C T A E N T L F Y V K E S T L W L T S L N A C L D P F I Y F F L C K S L I S F R N S M
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Residue Table


GPCRdb(A)
GPCRdb(A)
P2Y12 receptor
TM3
3x21 3.21x21 R93
3x25 3.25x25 C97
3x29 3.29x29 S101
3x30 3.30x30 V102
3x33 3.33x33 Y105
3x34 3.34x34 F106
TM4
4x57 4.57x57 S156
4x60 4.60x60 N159
ECL2
45x50 45.50x50 C175
45x51 45.51x51 S176
TM5
5x36 5.36x36 H187
5x39 5.39x39 V190
5x40 5.40x40 N191
5x43 5.43x43 C194
TM6
6x55 6.55x55 R256
6x58 6.58x58 Y259
6x62 6.62x62 Q263
TM7
7x34 7.35x34 K280