Structure information

MC4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6W25

SPECIES

Homo sapiens

RESOLUTION

2.750

PREFERRED CHAIN

A

REFERENCE

10.1126/SCIENCE.AAZ8995

PUBLICATION DATE

April 29, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
SHU9119 F51 1.39x39 TM1 hydrophobic
SHU9119 L97 2.57x57 TM2 hydrophobic
SHU9119 E100 2.60x60 TM2 polar (charge-assisted hydrogen bond)
SHU9119 T101 2.61x61 TM2 polar (hydrogen bond)
SHU9119 I104 2.64x64 TM2 Van der Waals
SHU9119 I104 2.64x64 TM2 hydrophobic
SHU9119 D122 3.25x25 TM3 polar (charge-assisted hydrogen bond)
SHU9119 N123 3.26x26 TM3 polar (hydrogen bond)
SHU9119 D126 3.29x29 TM3 polar (charge-assisted hydrogen bond)
SHU9119 I129 3.32x32 TM3 hydrophobic
SHU9119 I129 3.32x32 TM3 Van der Waals
SHU9119 C130 3.33x33 TM3 hydrophobic
SHU9119 C130 3.33x33 TM3 Van der Waals
SHU9119 L133 3.36x36 TM3 Van der Waals
SHU9119 I185 4.61x61 TM4 polar (hydrogen bond with backbone)
SHU9119 I185 4.61x61 TM4 Van der Waals
SHU9119 S188 4.64x64 TM4 polar (hydrogen bond)
SHU9119 S188 4.64x64 TM4 polar (hydrogen bond with backbone)
SHU9119 I194 5.40x40 TM5 Van der Waals
SHU9119 I194 5.40x40 TM5 hydrophobic
SHU9119 L197 5.43x43 TM5 hydrophobic
SHU9119 L197 5.43x43 TM5 Van der Waals
SHU9119 W258 6.48x48 TM6 hydrophobic
SHU9119 F261 6.51x51 TM6 Van der Waals
SHU9119 F261 6.51x51 TM6 hydrophobic
SHU9119 H264 6.54x54 TM6 polar (hydrogen bond)
SHU9119 H264 6.54x54 TM6 polar (hydrogen bond)
SHU9119 L265 6.55x55 TM6 hydrophobic
SHU9119 L265 6.55x55 TM6 Van der Waals
SHU9119 Y268 6.58x58 TM6 polar (hydrogen bond)
SHU9119 Y268 6.58x58 TM6 aromatic (face-to-edge)
SHU9119 M281 ECL3 Van der Waals
SHU9119 F284 7.35x34 TM7 hydrophobic
SHU9119 F284 7.35x34 TM7 Van der Waals
SHU9119 L288 7.39x38 TM7 Van der Waals
SHU9119 L288 7.39x38 TM7 hydrophobic

Ligands

SHU9119

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Residue Diagrams

I N E L L S I V G L T V F V E P S 1 C S L A V A D M L V S V S N G S E T I V 2 S L L S C I S A L L S S C I V S D I V N 3 V G I I I S C I W A A C T V S G I L F I 4 Y L S A M L A L M T F F M T I L C I I V 5 T I L I G V F V V C W A P F F L H L I F 6 L P D I I S N C M I L I L Y L N F H 7
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ICL1 K N L H ICL1ECL1 N S T D T D A ECL1ICL2 A L Q Y H N I M ICL2ECL2 D ECL2ICL3 P G T G A I R ICL3ECL3 P Q N P Y C V C F M S ECL3N-term M V N S T H R G M H T S L H L W N R S S Y R L H S N A S E S L G K G Y S D G G C Y E Q L F V N-termC-term P L G G L C D L S S R Y C-term S P E V F V T L G V I S L L E N I L V I V A I A K N S P M Y F F I C S L A V A D M L V S V S N G S E T I V I T L L Q S F T V N I D N V I D S V I C S S L L A S I C S L L S I A V D R Y F T I F Y T V K R V G I I I S C I W A A C T V S G I L F I I Y S S S A V I I C L I T M F F T M L A L M A S L Y V H M F L M A R L H I K R I A V L Q G A N M K G A I T L T I L I G V F V V C W A P F F L H L I F Y I S C H F N L Y L I L I M C N S I I D P L I Y A L R S Q E F K E Y L R K T I I C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
MC4 receptor
TM1
1x39 1.39x39 F51
TM2
2x57 2.57x57 N97
2x60 2.60x60 E100
2x61 2.61x61 T101
2x64 2.64x64 I104
TM3
3x25 3.25x25 D122
3x26 3.26x26 N123
3x29 3.29x29 D126
3x32 3.32x32 I129
3x33 3.33x33 C130
3x36 3.36x36 L133
TM4
4x61 4.61x61 I185
4x64 4.64x64 S188
TM5
5x40 5.40x40 I194
5x43 5.43x43 L197
TM6
6x48 6.48x48 W258
6x51 6.51x51 F261
6x54 6.54x54 H264
6x55 6.55x55 L265
6x58 6.58x58 Y268
TM7
7x34 7.35x34 F284
7x38 7.39x38 L288