Structure information

D1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7CKW

SPECIES

Homo sapiens

RESOLUTION

3.220

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2021.01.028

PUBLICATION DATE

March 3, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
fenoldopam D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
fenoldopam I104 3.33x33 TM3 Van der Waals
fenoldopam I104 3.33x33 TM3 hydrophobic
fenoldopam S107 3.36x36 TM3 Van der Waals
fenoldopam D187 45.51x51 ECL2 Van der Waals
fenoldopam S188 45.52x52 ECL2 polar (hydrogen bond with backbone)
fenoldopam S188 45.52x52 ECL2 Van der Waals
fenoldopam L190 ECL2 hydrophobic
fenoldopam L190 ECL2 Van der Waals
fenoldopam A195 5.39x40 TM5 Van der Waals
fenoldopam S198 5.42x43 TM5 Van der Waals
fenoldopam S198 5.42x43 TM5 polar (hydrogen bond)
fenoldopam S199 5.43x44 TM5 polar (hydrogen bond with backbone)
fenoldopam S199 5.43x44 TM5 Van der Waals
fenoldopam S199 5.43x44 TM5 polar (hydrogen bond)
fenoldopam F288 6.51x51 TM6 aromatic (edge-to-face)
fenoldopam F288 6.51x51 TM6 Van der Waals
fenoldopam F289 6.52x52 TM6 Van der Waals
fenoldopam F289 6.52x52 TM6 hydrophobic
fenoldopam N292 6.55x55 TM6 Van der Waals
fenoldopam N292 6.55x55 TM6 polar (hydrogen bond)
fenoldopam F313 7.35x34 TM7 Van der Waals
fenoldopam F313 7.35x34 TM7 hydrophobic
fenoldopam V317 7.39x38 TM7 Van der Waals

Ligands

fenoldopam

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Residue Diagrams

T N G L L T S L I L L S L F C A T L I R 1 I S L A V S D L L V A L V V M P W K A V A 2 V C L N L I S A T S C M I D F A V W I N 3 A F I L I S V A W T L S V L I S F I P V 4 Y T V I M I A V P I Y F S I V S S S I A Y 5 S V I M G V F V C C W L P F F I L N C I 6 I P N L S S N A W G F W V F V D F T N 7
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ICL1 R H L R S ICL1ECL1 F W P F ECL1ICL2 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P F C I ECL3N-term M R T L N T S A M D G T G L V V E R D F N-termC-term C Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T F R K A L L G
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Residue Table


GPCRdb(A)
GPCRdb(A)
D1 receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
ECL2
45x51 45.51x51 D187
45x52 45.52x52 S188
TM5
5x40 5.39x40 A195
5x43 5.42x43 S198
5x44 5.43x44 S199
TM6
6x51 6.51x51 F288
6x52 6.52x52 F289
6x55 6.55x55 N292
TM7
7x34 7.35x34 F313
7x38 7.39x38 V317