Structure information

D1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7CRH

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2021.01.028

PUBLICATION DATE

March 3, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL1416789 D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
CHEMBL1416789 I104 3.33x33 TM3 Van der Waals
CHEMBL1416789 I104 3.33x33 TM3 hydrophobic
CHEMBL1416789 S107 3.36x36 TM3 Van der Waals
CHEMBL1416789 L190 ECL2 Van der Waals
CHEMBL1416789 L190 ECL2 hydrophobic
CHEMBL1416789 S198 5.42x43 TM5 Van der Waals
CHEMBL1416789 S198 5.42x43 TM5 polar (hydrogen bond)
CHEMBL1416789 F288 6.51x51 TM6 aromatic (edge-to-face)
CHEMBL1416789 F288 6.51x51 TM6 Van der Waals
CHEMBL1416789 F289 6.52x52 TM6 hydrophobic
CHEMBL1416789 N292 6.55x55 TM6 Van der Waals
CHEMBL1416789 F313 7.35x34 TM7 Van der Waals
CHEMBL1416789 F313 7.35x34 TM7 hydrophobic
CHEMBL1416789 W321 7.43x42 TM7 Van der Waals

Ligands

CHEMBL1416789

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Residue Diagrams

T N G L L T S L I L L S L F C A T L I R 1 I S L A V S D L L V A L V V M P W K A V A 2 V C L N L I S A T S C M I D F A V W I N 3 A F I L I S V A W T L S V L I S F I P V 4 Y T V I M I A V P I Y F S I V S S S I A Y 5 S V I M G V F V C C W L P F F I L N C I 6 I P N L S S N A W G F W V F V D F T N 7
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ICL1 R H L R S ICL1ECL1 F W P F ECL1ICL2 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P F C I ECL3N-term M R T L N T S A M D G T G L V V E R D F N-termC-term C Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T F R K A L L G
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Residue Table


GPCRdb(A)
GPCRdb(A)
D1 receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
TM5
5x43 5.42x43 S198
TM6
6x51 6.51x51 F288
6x52 6.52x52 F289
6x55 6.55x55 N292
TM7
7x34 7.35x34 F313
7x42 7.43x42 W321