Structure information

D1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7JVQ

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2021.01.027

PUBLICATION DATE

Feb. 24, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
apomorphine D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
apomorphine I104 3.33x33 TM3 hydrophobic
apomorphine I104 3.33x33 TM3 Van der Waals
apomorphine S107 3.36x36 TM3 Van der Waals
apomorphine L190 ECL2 hydrophobic
apomorphine L190 ECL2 Van der Waals
apomorphine S198 5.42x43 TM5 polar (hydrogen bond with backbone)
apomorphine S198 5.42x43 TM5 polar (hydrogen bond)
apomorphine S199 5.43x44 TM5 Van der Waals
apomorphine S199 5.43x44 TM5 polar (hydrogen bond with backbone)
apomorphine S202 5.46x461 TM5 polar (hydrogen bond)
apomorphine F288 6.51x51 TM6 hydrophobic
apomorphine F288 6.51x51 TM6 Van der Waals
apomorphine F289 6.52x52 TM6 Van der Waals
apomorphine F289 6.52x52 TM6 aromatic (edge-to-face)
apomorphine N292 6.55x55 TM6 Van der Waals
apomorphine N292 6.55x55 TM6 polar (hydrogen bond)
apomorphine V317 7.39x38 TM7 hydrophobic
apomorphine V317 7.39x38 TM7 Van der Waals
apomorphine W321 7.43x42 TM7 hydrophobic
apomorphine W321 7.43x42 TM7 Van der Waals

Ligands

apomorphine

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Residue Diagrams

T N G L L T S L I L L S L F C A T L I R 1 I S L A V S D L L V A L V V M P W K A V A 2 V C L N L I S A T S C M I D F A V W I N 3 A F I L I S V A W T L S V L I S F I P V 4 Y T V I M I A V P I Y F S I V S S S I A Y 5 S V I M G V F V C C W L P F F I L N C I 6 I P N L S S N A W G F W V F V D F T N 7
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ICL1 R H L R S ICL1ECL1 F W P F ECL1ICL2 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P F C I ECL3N-term M R T L N T S A M D G T G L V V E R D F N-termC-term C Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T F R K A L L G
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Residue Table


GPCRdb(A)
GPCRdb(A)
D1 receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
TM5
5x43 5.42x43 S198
5x44 5.43x44 S199
5x461 5.46x461 S202
TM6
6x51 6.51x51 F288
6x52 6.52x52 F289
6x55 6.55x55 N292
TM7
7x38 7.39x38 V317
7x42 7.43x42 W321