Structure information

S1P2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7T6B

SPECIES

Homo sapiens

RESOLUTION

3.190

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIADV.ABN0067

PUBLICATION DATE

April 6, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
sphingosine 1-phosphate N89 2.60x60 TM2 polar (hydrogen bond)
sphingosine 1-phosphate N89 2.60x60 TM2 Van der Waals
sphingosine 1-phosphate S93 2.64x64 TM2 Van der Waals
sphingosine 1-phosphate S93 2.64x64 TM2 polar (hydrogen bond with backbone)
sphingosine 1-phosphate L98 23.51x501 ECL1 Van der Waals
sphingosine 1-phosphate E109 3.29x29 TM3 polar (charge-assisted hydrogen bond)
sphingosine 1-phosphate F113 3.33x33 TM3 hydrophobic
sphingosine 1-phosphate F113 3.33x33 TM3 Van der Waals
sphingosine 1-phosphate L116 3.36x36 TM3 hydrophobic
sphingosine 1-phosphate L116 3.36x36 TM3 Van der Waals
sphingosine 1-phosphate S117 3.37x37 TM3 Van der Waals
sphingosine 1-phosphate F121 3.41x41 TM3 Van der Waals
sphingosine 1-phosphate F121 3.41x41 TM3 hydrophobic
sphingosine 1-phosphate L183 ECL2 hydrophobic
sphingosine 1-phosphate L183 ECL2 Van der Waals
sphingosine 1-phosphate V194 5.43x43 TM5 Van der Waals
sphingosine 1-phosphate F198 5.47x47 TM5 hydrophobic
sphingosine 1-phosphate W246 6.48x48 TM6 hydrophobic
sphingosine 1-phosphate W246 6.48x48 TM6 Van der Waals
sphingosine 1-phosphate F274 7.39x38 TM7 hydrophobic
sphingosine 1-phosphate F274 7.39x38 TM7 Van der Waals

Ligands

sphingosine 1-phosphate

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Residue Diagrams

L N E V V I A C C L I V I F A S A V Q R 1 G N L A A S D L L A G V A F V A N T L L 2 A L L S F V S A S L T I F A S G E R A F 3 M L L L I G A S W L I S L V L G G L P I 4 Y L A V I A L L I I S F I T V V C L V Y 5 T I V L G V F I V C W L P A F S I L L L 6 V P N L L S N L T S V A F F Y H A K Y 7
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ICL1 S K F H ICL1ECL1 G S V T L R L ECL1ICL2 V K L Y G S D ICL2ECL2 W N C L G H L E A C S T V L P L Y ECL2ICL3 H A D M ICL3ECL3 P V H S C ECL3N-term M G S L Y S E Y L N P N K V Q E H Y N Y T K E T L E T Q E N-termC-term C W R P G V G V Q G R R R G G T P G H H L L P L R S S S S L E R G M H M P T S P T F L E G N T V V C-term T T S R Q V A S A F I V I L C C A I V V E N L L V L I A V A R N S A M Y L F L G N L A A S D L L A G V A F V A N T L L S T P V Q W F A R E G S A F I T L S A S V F S L L A I A I E R H V A I A K K S C R M L L L I G A S W L I S L V L G G L P I L G A K H Y V L C V V T I F S I I L L A I V A L Y V R I Y C V V R S S A A P Q T L A L L K T V T I V L G V F I V C W L P A F S I L L L D Y A C P I L Y K A H Y F F A V S T L N S L L N P V I Y T W R S R D V L R L R R E P L Q
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Residue Table


GPCRdb(A)
GPCRdb(A)
S1P2 receptor
TM2
2x60 2.60x60 N89
2x64 2.64x64 S93
ECL1
23x501 23.51x501 L98
TM3
3x29 3.29x29 E109
3x33 3.33x33 F113
3x36 3.36x36 L116
3x37 3.37x37 S117
3x41 3.41x41 F121
TM5
5x43 5.43x43 V194
5x47 5.47x47 F198
TM6
6x48 6.48x48 W246
TM7
7x38 7.39x38 F274