Structure information

M3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8E9Y

SPECIES

Homo sapiens

RESOLUTION

2.790

PREFERRED CHAIN

A

REFERENCE

10.1038/S41586-022-05489-0

PUBLICATION DATE

Nov. 30, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Clozapine N-oxide D148 3.32x32 TM3 polar (charge-charge)
Clozapine N-oxide C149 3.33x33 TM3 hydrophobic
Clozapine N-oxide C149 3.33x33 TM3 Van der Waals
Clozapine N-oxide S152 3.36x36 TM3 Van der Waals
Clozapine N-oxide N153 3.37x37 TM3 Van der Waals
Clozapine N-oxide W200 4.57x57 TM4 Van der Waals
Clozapine N-oxide W200 4.57x57 TM4 aromatic (edge-to-face)
Clozapine N-oxide T232 5.39x40 TM5 Van der Waals
Clozapine N-oxide T235 5.42x43 TM5 Van der Waals
Clozapine N-oxide A236 5.43x44 TM5 hydrophobic
Clozapine N-oxide A236 5.43x44 TM5 Van der Waals
Clozapine N-oxide G239 5.46x461 TM5 Van der Waals
Clozapine N-oxide W504 6.48x48 TM6 Van der Waals
Clozapine N-oxide W504 6.48x48 TM6 aromatic (edge-to-face)
Clozapine N-oxide Y507 6.51x51 TM6 polar (hydrogen bond)
Clozapine N-oxide N508 6.52x52 TM6 polar (hydrogen bond)
Clozapine N-oxide V511 6.55x55 TM6 hydrophobic
Clozapine N-oxide V511 6.55x55 TM6 Van der Waals
Clozapine N-oxide Y530 7.39x38 TM7 hydrophobic
Clozapine N-oxide Y530 7.39x38 TM7 Van der Waals
Clozapine N-oxide C533 7.42x41 TM7 Van der Waals
Clozapine N-oxide Y534 7.43x42 TM7 polar (charge-assisted hydrogen bond)

Ligands

Clozapine N-oxide

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Residue Diagrams

I N G I I T V L A L I G T L F A I F V V 1 L S L A C A D L I I G I V S M N L F T T Y 2 V L L N M V S A N S A V Y D I A L W L D 3 A G V M I G L A W V I S F V L W A P A I 4 Y L I T M I T V P M Y F A A I A T G F T I 5 S A I L L A F I I T W T P Y N I M V L V 6 V P N V T S N I Y C L W Y G L N W F T 7
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ICL1 K Q L K ICL1ECL1 N R W A L ECL1ICL2 P L T Y R A K R ICL2ECL2 K R T V P P G E C F I Q F L S ECL2ICL3 Q A S G T E A E T E N F V H P T G S S R S C S S Y E L Q Q Q S M K R S N R R K Y G R C H F W F T T K S W K P S S E Q M D Q D H S S S D S W N N N D A A A S L E N S A S S D E E D I G S E T R A I Y S I V L K L P G H S T I L N S T K L P S S D N L Q V P E E E L G M V D L E R K A D K L Q A Q K S V D D G G S F P K S F S K L P I Q L E S A V D T A K T S D V N S S V G K S T A T L P L S F K E A T L A K R F A L K T R S Q I T K R K ICL3ECL3 D S C I ECL3N-term M T L H N N S T T S P L F P N I S S S W I H S P S D A G L P P G T V T H F G S Y N V S R A A G N F S S P D G T T D D P L G G H N-termC-term Q C D K K K R R K Q Q Y Q Q R Q S V I F H K R A P E Q A L C-term T V W Q V V F I A F L T G I L A L V T I I G N I L V I V S F K V N T V N N Y F L L S L A C A D L I I G V I S M N L F T T Y I I M G N L A C D L W L A I D Y V A S N A S V M N L L V I S F D R Y F S I T R T T K R A G V M I G L A W V I S F V L W A P A I L F W Q Y F V G E P T I T F G T A I A A F Y M P V T I M T I L Y W R I Y K E T E K R T K E L A G L R M S L V K E K K A A Q T L S A I L L A F I I T W T P Y N I M V L V N T F C P K T F W N L G Y W L C Y I N S T V N P V C Y A L C N K T F K M F R T T L L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
M3 receptor
TM3
3x32 3.32x32 D148
3x33 3.33x33 Y149
3x36 3.36x36 S152
3x37 3.37x37 N153
TM4
4x57 4.57x57 W200
TM5
5x40 5.39x40 T232
5x43 5.42x43 T235
5x44 5.43x44 A236
5x461 5.46x461 A239
TM6
6x48 6.48x48 W504
6x51 6.51x51 Y507
6x52 6.52x52 N508
6x55 6.55x55 V511
TM7
7x38 7.39x38 Y530
7x41 7.42x41 C533
7x42 7.43x42 Y534